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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PSME4-SLC22A16 (FusionGDB2 ID:69758)

Fusion Gene Summary for PSME4-SLC22A16

Fusion gene summary

Fusion gene information	Fusion gene name: PSME4-SLC22A16
	Fusion gene ID: 69758
		Hgene	Tgene
	Gene symbol	PSME4	SLC22A16
	Gene ID	23198	85413
	Gene name	proteasome activator subunit 4	solute carrier family 22 member 16
	Synonyms	PA200	CT2\|FLIPT2\|HEL-S-18\|OAT6\|OCT6\|OKB1\|dJ261K5.1
	Cytomap	2p16.2	6q21\|6q21-q22.1
	Type of gene	protein-coding	protein-coding
	Description	proteasome activator complex subunit 4proteasome (prosome, macropain) activator subunit 4proteasome activator 200 kDaproteasome activator PA200	solute carrier family 22 member 16WUGSC:RG331P03.1carnitine transporter 2epididymis secretory protein Li 18flipt 2fly-like putative organic ion transporter 2fly-like putative transporter 2organic cation transporter 6organic cation transporter OKB1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000404125, ENST00000421748, ENST00000476586,	ENST00000461487, ENST00000330550, ENST00000368919, ENST00000439654, ENST00000456137,
Fusion gene scores	* DoF score	4 X 3 X 4=48	4 X 5 X 5=100
	# samples	4	9
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/100*10)=-0.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PSME4 [Title/Abstract] AND SLC22A16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PSME4(54101476)-SLC22A16(110778220), # samples:2
Anticipated loss of major functional domain due to fusion event.	PSME4-SLC22A16 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PSME4-SLC22A16 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SLC22A16	GO:0015695	organic cation transport	12089149\|15963465
Tgene	SLC22A16	GO:0015879	carnitine transport	12089149
Tgene	SLC22A16	GO:0046717	acid secretion	12089149

Fusion gene breakpoints across PSME4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC22A16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1F0-01A	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-

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Fusion Gene ORF analysis for PSME4-SLC22A16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000404125	ENST00000461487	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
5CDS-5UTR	ENST00000421748	ENST00000461487	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
Frame-shift	ENST00000404125	ENST00000330550	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
Frame-shift	ENST00000404125	ENST00000368919	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
Frame-shift	ENST00000404125	ENST00000439654	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
Frame-shift	ENST00000421748	ENST00000330550	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
Frame-shift	ENST00000421748	ENST00000368919	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
Frame-shift	ENST00000421748	ENST00000439654	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
In-frame	ENST00000404125	ENST00000456137	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
In-frame	ENST00000421748	ENST00000456137	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
intron-3CDS	ENST00000476586	ENST00000330550	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
intron-3CDS	ENST00000476586	ENST00000368919	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
intron-3CDS	ENST00000476586	ENST00000439654	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
intron-3CDS	ENST00000476586	ENST00000456137	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-
intron-5UTR	ENST00000476586	ENST00000461487	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000421748	PSME4	chr2	54101476	-	ENST00000456137	SLC22A16	chr6	110778220	-	3673	2532	0	2672	890
ENST00000404125	PSME4	chr2	54101476	-	ENST00000456137	SLC22A16	chr6	110778220	-	6297	5156	56	5296	1746

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000421748	ENST00000456137	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-	0.000444257	0.99955577
ENST00000404125	ENST00000456137	PSME4	chr2	54101476	-	SLC22A16	chr6	110778220	-	0.000623782	0.99937624

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Fusion Genomic Features for PSME4-SLC22A16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSME4-SLC22A16

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54101476/chr6:110778220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

1179_1217

1700

2246.3333333333335

Repeat

Note=HEAT 3

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

1354_1392

1700

2246.3333333333335

Repeat

Note=HEAT 4

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

1636_1674

1700

2246.3333333333335

Repeat

Note=HEAT 5

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

475_519

1700

2246.3333333333335

Repeat

Note=HEAT 1

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

998_1037

1700

2246.3333333333335

Repeat

Note=HEAT 2

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

152_172

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

183_203

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

214_234

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

23_43

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

244_264

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

268_288

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

359_379

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

389_409

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

416_436

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

441_461

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

476_496

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000330550

501_521

544.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

152_172

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

183_203

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

214_234

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

23_43

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

244_264

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

268_288

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

359_379

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

389_409

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

416_436

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

441_461

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

476_496

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000368919

501_521

578.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

152_172

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

183_203

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

214_234

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

23_43

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

244_264

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

268_288

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

359_379

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

389_409

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

416_436

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

441_461

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

476_496

516.0

Transmembrane

Helical

Tgene

SLC22A16

chr2:54101476

chr6:110778220

ENST00000439654

501_521

516.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

1650_1738

1700

2246.3333333333335

Region

Note=Bromodomain-like (BRDL)

Hgene

PSME4

chr2:54101476

chr6:110778220

ENST00000404125

1680_1718

1700

2246.3333333333335

Repeat

Note=HEAT 6

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Fusion Gene Sequence for PSME4-SLC22A16

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>69758_69758_1_PSME4-SLC22A16_PSME4_chr2_54101476_ENST00000404125_SLC22A16_chr6_110778220_ENST00000456137_length(transcript)=6297nt_BP=5156nt
GGTGGGGGCCGGGGAGGGTTCGGGTGGGAGGGGGTGGGGGGGGTGTCCCTGGGCTCATGGAGCCGGCCGAGCGGGCGGGAGTCGGAGAGC
CCCCGGAGCCGGGCGGGCGTCCCGAGCCGGGCCCGCGGGGCTTCGTCCCGCAGAAGGAGATCGTCTACAACAAGCTGCTGCCCTACGCGG
AGCGGCTAGACGCCGAGTCCGACTTGCAGCTGGCCCAGATCAAATGCAACCTGGGCCGGGCCGTGCAGCTCCAAGAGCTGTGGCCCGGGG
GCCTCTTCTGGACCAGGAAACTCTCCACATATATTCGACTTTATGGGAGAAAATTTAGCAAAGAAGATCATGTTCTTTTTATTAAGTTAT
TGTATGAGCTGGTATCAATTCCAAAACTGGAAATCAGCATGATGCAGGGATTTGCCCGCCTTTTGATCAACTTGTTAAAGAAAAAGGAAC
TTCTTTCAAGAGCTGATTTGGAGTTACCCTGGAGACCACTTTATGACATGGTAGAAAGAATATTATATTCCAAGACAGAGCACCTAGGAT
TAAATTGGTTTCCTAATTCTGTAGAAAATATTCTCAAAACACTCGTGAAAAGCTGCCGACCATATTTTCCAGCAGATGCCACCGCTGAGA
TGCTAGAAGAATGGCGACCTTTAATGTGCCCTTTTGATGTAACCATGCAAAAGGCCATCACTTATTTTGAAATATTTCTTCCTACCTCCC
TTCCTCCAGAACTTCATCATAAAGGTTTTAAACTTTGGTTTGATGAATTAATTGGCCTTTGGGTTTCAGTGCAAAATCTCCCACAATGGG
AGGGGCAACTAGTAAATCTCTTTGCTCGATTGGCTACAGATAATATAGGGTACATAGATTGGGATCCATATGTACCAAAGATATTTACAA
GAATTCTGAGAAGCTTGAACCTCCCAGTGGGAAGCAGTCAAGTGTTAGTCCCAAGATTTTTAACAAATGCTTATGATATAGGACATGCTG
TAATATGGATCACCGCCATGATGGGTGGACCAAGTAAGCTAGTGCAAAAACACTTAGCTGGTTTGTTTAACAGCATCACATCTTTTTACC
ATCCTTCAAATAATGGGCGCTGGCTGAACAAGTTAATGAAACTACTTCAGCGGTTGCCAAACAGTGTTGTTAGAAGATTGCATCGTGAAA
GATACAAGAAGCCCTCTTGGTTAACTCCTGTGCCTGATAGCCACAAGCTTACTGATCAAGATGTTACAGACTTTGTACAATGCATTATTC
AGCCTGTCCTCTTGGCTATGTTTAGCAAAACCGGTAGTCTAGAAGCAGCCCAGGCTTTGCAGAATCTTGCACTCATGAGACCTGAATTGG
TAATACCCCCTGTACTTGAAAGAACATATCCTGCATTAGAGACATTAACAGAACCTCACCAGCTCACAGCTACTTTAAGTTGTGTAATTG
GAGTAGCCCGCAGTTTGGTATCAGGAGGCAGATGGTTTCCTGAAGGTCCTACACATATGCTACCTCTGTTGATGAGAGCATTGCCTGGGG
TGGATCCAAATGACTTTAGTAAATGCATGATCACATTCCAGTTCATAGCAACATTTTCTACTCTGGTGCCTTTAGTAGATTGTTCATCTG
TACTACAAGAAAGAAATGACCTCACAGAAGTGGAACGAGAACTTTGTTCAGCCACAGCTGAATTTGAGGATTTCGTCTTACAGTTTATGG
ACAGATGTTTTGGACTTATAGAAAGTAGCACATTGGAGCAAACAAGAGAAGAGACAGAAACTGAGAAAATGACACACTTGGAGAGTTTGG
TCGAATTAGGTCTGTCTTCTACGTTTAGTACAATCCTCACCCAATGTTCCAAAGAAATATTTATGGTGGCCCTTCAGAAGGTTTTTAATT
TTTCTACTTCACATATATTTGAAACAAGAGTAGCAGGTCGCATGGTGGCAGACATGTGCCGCGCTGCTGTAAAGTGCTGCCCAGAAGAAT
CTTTGAAGCTCTTTGTTCCCCACTGCTGCAGTGTTATAACTCAGCTTACAATGAATGATGATGTATTAAATGATGAAGAGCTAGACAAGG
AATTACTATGGAATCTTCAACTTTTGTCTGAGATTACTCGAGTGGATGGAAGGAAGTTGCTTCTTTATAGGGAGCAGCTTGTAAAGATTC
TCCAAAGAACCCTACATTTAACCTGTAAGCAGGGTTACACTCTGTCTTGTAACCTTTTGCATCATCTTCTCCGTTCTACCACACTTATCT
ACCCTACAGAATACTGCAGTGTGCCAGGTGGCTTTGACAAGCCTCCTTCTGAATACTTTCCTATCAAGGACTGGGGCAAACCCGGGGACT
TGTGGAATCTGGGAATCCAGTGGCATGTTCCTTCTTCAGAAGAAGTGTCTTTTGCCTTTTATCTTTTGGACTCCTTTCTTCAGCCTGAGC
TCGTCAAACTCCAGCATTGTGGGGATGGAAAACTTGAAATGTCTAGAGATGATATTCTACAGAGTCTGACTATAGTGCACAACTGTTTAA
TTGGCTCTGGAAACCTCCTACCTCCGTTGAAAGGAGAGCCAGTTACTAACTTAGTACCAAGTATGGTGTCCTTGGAAGAGACAAAGTTGT
ATACTGGACTTGAATATGATCTGTCTCGAGAGAACCACCGAGAAGTAATTGCTACAGTTATAAGGAAACTTCTTAACCACATACTTGATA
ATTCAGAAGATGATACTAAGTCATTGTTTCTTATTATAAAGATTATTGGAGACCTTTTACAATTCCAAGGATCTCACAAGCATGAATTTG
ACTCCCGATGGAAAAGCTTCAACTTAGTAAAGAAATCAATGGAAAATCGGCTCCATGGGAAAAAACAACATATCAGAGCACTGTTGATTG
ATAGAGTAATGTTACAGCATGAGCTACGGACACTAACTGTTGAGGGTTGTGAATACAAAAAGATACATCAAGATATGATCAGAGATCTTC
TTCGTTTATCTACAAGTTCATACAGTCAGGTGAGAAATAAGGCTCAGCAAACATTTTTTGCTGCCTTGGGAGCATATAACTTCTGTTGCA
GAGATATCATTCCCTTGGTTTTGGAGTTCTTAAGGCCTGATAGACAAGGTGTTACACAGCAACAATTCAAGGGTGCCTTGTACTGTCTCC
TTGGAAATCACAGTGGTGTGTGCTTGGCAAACCTTCATGATTGGGACTGTATTGTACAGACGTGGCCAGCGATTGTTTCTTCAGGGCTTA
GCCAAGCAATGTCCCTGGAAAAGCCATCAATAGTGAGATTGTTTGATGATCTTGCAGAAAAGATTCATAGGCAGTATGAAACAATTGGCT
TGGACTTCACAATTCCAAAGTCATGTGTTGAAATAGCGGAATTACTTCAACAGTCAAAAAACCCCTCTATCAACCAGATATTGCTTAGCC
CAGAAAAAATTAAGGAAGGAATTAAACGCCAACAGGAAAAGAATGCCGATGCCCTAAGGAACTATGAAAATTTGGTAGACACCTTGCTAG
ATGGTGTGGAGCAAAGAAACCTGCCCTGGAAATTTGAACATATAGGCATTGGGCTTCTGTCTCTACTGCTGAGAGATGACCGAGTGTTGC
CTCTTCGTGCCATACGGTTTTTTGTTGAGAATCTCAACCATGATGCAATTGTAGTTCGAAAGATGGCTATCTCAGCTGTTGCTGGTATCC
TTAAACAGCTAAAAAGAACCCACAAAAAGCTGACCATTAACCCCTGTGAAATCAGTGGATGCCCTAAACCCACCCAAATTATTGCTGGTG
ATAGGCCTGATAATCATTGGTTGCATTATGACAGCAAAACTATACCAAGAACTAAAAAAGAATGGGAGTCAAGTTGCTTTGTGGAAAAAA
CTCACTGGGGATACTACACCTGGCCAAAGAATATGGTTGTTTATGCTGGTGTGGAAGAGCAGCCTAAGCTTGGCAGAAGCAGGGAGGATA
TGACAGAGGCAGAACAGATTATATTTGATCATTTTTCTGATCCTAAATTTGTTGAGCAGTTAATTACTTTTCTATCATTAGAAGACAGAA
AAGGAAAAGATAAGTTTAATCCACGACGTTTTTGCCTCTTTAAGGGTATATTCAGGAATTTTGATGATGCCTTCCTGCCAGTTCTGAAGC
CCCATTTAGAACATTTGGTTGCAGATTCACATGAAAGCACCCAGCGATGTGTTGCAGAAATTATAGCTGGTTTAATCAGAGGTTCTAAGC
ACTGGACATTTGAAAAGGTGGAGAAGCTTTGGGAGCTTCTGTGCCCTCTGCTTAGAACAGCACTGTCCAATATTACCGTAGAAACTTATA
ATGACTGGGGAGCTTGTATAGCAACATCCTGTGAAAGCAGAGATCCCCGGAAACTTCACTGGCTTTTTGAACTGCTGTTGGAATCACCAT
TGAGTGGTGAAGGAGGATCCTTTGTAGATGCATGTCGACTTTATGTACTACAAGGTGGCCTTGCCCAGCAAGAATGGAGAGTGCCTGAAC
TATTGCACAGACTACTGAAGTACTTGGAACCCAAACTCACCCAGGTTTACAAAAATGTCAGAGAAAGAATAGGAAGTGTGCTGACCTACA
TATTCATGATAGATGTATCTTTGCCAAATACCACACCAACCATATCGCCTCATGTCCCTGAGTTTACTGCTCGAATTCTGGAGAAATTGA
AACCTCTCATGGATGTGGATGAAGAAATTCAGAACCATGTTATGGAAGAAAATGGAATTGGTGAAGAAGATGAGCGAACTCAGGGCATTA
AACTCTTGAAAACCATATTGAAATGGCTGATGGCAAGTGCAGGAAGATCCTTTTCTACAGCAGTTACAGAACAACTTCAGCTTCTACCTT
TGTTTTTCAAGATTGCCCCAGTGGAAAATGACAATAGCTACGATGAACTGAAAAGAGATGCAAAGTTATGTTTATCATTAATGTCTCAGG
GGTTGCTTTACCCTCATCAAGTGCCTTTGGTACTTCAGGTGCTAAAACAAACAGCAAGAAGCAGTTCTTGGCATGCACGATACACAGTAC
TGACCTACCTCCAGACCATGGTATTTTATAACCTCTTTATTTTCCTAAACAATGAAGATGCAGTTAAAGATATCAGGTGGCTGGTTATAA
GTCTTTTGGAGGACGAACAACTGGAGATTCCAGAGAGTCCTCTATTTCATATGTGCCTTCCAGAACATCTCTTGTGGTATTCACTACTTG
GCTTCTGTGTTCATGGGAGTCACCCCTCATCATGTCTGCAGGCCCCCAGGCAATGTGAGTCAGGTTGTTTTCCATAATCACTCTAATTGG
AGTTTGGAGGACACCGGGGCCCTGTTGTCTTCAGGCCAGAAAGATTATGTTACGGTGCAGTTGCAGAATGGTGAGATCTGGGAGCTCTCA
AGGTGTAGCAGGAATAAGAGGGAGAACACATCGAGTTTGGGCTATGAATACACTGGCAGTAAGAAAGAGTTTCCTTGTGTGGATGGCTAC
ATATATGACCAGAACACATGGAAAAGCACTGCGGTGACCCAGTGGAACCTGGTCTGTGACCGAAAATGGCTTGCAATGCTGATCCAGCCC
CTATTTATGTTTGGAGTCCTACTGGGATCGGTGACTTTTGGCTACTTTTCTGACAGAGTAGGCTTCCTAACTGCTTGGTACAAAACCAGT
GGATTCCCCACATCCAGTGCTCCTCCTCTCTAATTCAACCCACTATCTGTGAAGTGTCATCTGGACTCATTGTGGGACTTGGGGATTAGA
GGACCTGAGACAAAGATGCTGCTGCCCTACTGCTTGCTAACGAAGCTAGGACGCCGGGTGGTCTTGTGGGCCACAAGCAGTAGCATGTTT
TTGTTTGGAATAGCAGCGGCGTTTGCAGTTGATTATTACACCTTCATGGCTGCTCGCTTTTTTCTTGCCATGGTTGCAAGTGGCTATCTT
GTGGTGGGGTTTGTCTATGTGATGGAATTCATTGGCATGAAGTCTCGGACATGGGCGTCTGTCCATTTGCATTCCTTTTTTGCAGTTGGA
ACCCTGCTGGTGGCTTTGACAGGATACTTGGTCAGGACCTGGTGGCTTTACCAGATGATCCTCTCCACAGTGACTGTCCCCTTTATCCTG
TGCTGTTGGGTGCTCCCAGAGACACCTTTTTGGCTTCTCTCAGAGGGACGATATGAAGAAGCACAAAAAATAGTTGACATCATGGCCAAG

>69758_69758_1_PSME4-SLC22A16_PSME4_chr2_54101476_ENST00000404125_SLC22A16_chr6_110778220_ENST00000456137_length(amino acids)=1746AA_BP=1698
MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKF
SKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKTLVKSC
RPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYI
DWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRL
PNSVVRRLHRERYKKPSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEP
HQLTATLSCVIGVARSLVSGGRWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVLQERNDLTEVERELCSAT
AEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKEIFMVALQKVFNFSTSHIFETRVAGRMVADM
CRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVLNDEELDKELLWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNL
LHHLLRSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELVKLQHCGDGKLEMSRDDI
LQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEYDLSRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIGDL
LQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTF
FAALGAYNFCCRDIIPLVLEFLRPDRQGVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRLFDDLA
EKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIKEGIKRQQEKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGL
LSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTK
KEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVEQLITFLSLEDRKGKDKFNPRRFCLFKGIFR
NFDDAFLPVLKPHLEHLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYNDWGACIATSCESRDPRKL
HWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTTPTISPHV
PEFTARILEKLKPLMDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVTEQLQLLPLFFKIAPVENDNSYDELKR
DAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLVISLLEDEQLEIPESPLFHMC

--------------------------------------------------------------
>69758_69758_2_PSME4-SLC22A16_PSME4_chr2_54101476_ENST00000421748_SLC22A16_chr6_110778220_ENST00000456137_length(transcript)=3673nt_BP=2532nt
ATGGGAGAAAATTTAGCAAAGAAGATCATGTTCTTTTTATTAACTATAAAATTGATCCTGAACCACATACTTGATAATTCAGAAGATGAT
ACTAAGTCATTGTTTCTTATTATAAAGATTATTGGAGACCTTTTACAATTCCAAGGATCTCACAAGCATGAATTTGACTCCCGATGGAAA
AGCTTCAACTTAGTAAAGAAATCAATGGAAAATCGGCTCCATGGGAAAAAACAACATATCAGAGCACTGTTGATTGATAGAGTAATGTTA
CAGCATGAGCTACGGACACTAACTGTTGAGGGTTGTGAATACAAAAAGATACATCAAGATATGATCAGAGATCTTCTTCGTTTATCTACA
AGTTCATACAGTCAGGTGAGAAATAAGGCTCAGCAAACATTTTTTGCTGCCTTGGGAGCATATAACTTCTGTTGCAGAGATATCATTCCC
TTGGTTTTGGAGTTCTTAAGGCCTGATAGACAAGGTGTTACACAGCAACAATTCAAGGGTGCCTTGTACTGTCTCCTTGGAAATCACAGT
GGTGTGTGCTTGGCAAACCTTCATGATTGGGACTGTATTGTACAGACGTGGCCAGCGATTGTTTCTTCAGGGCTTAGCCAAGCAATGTCC
CTGGAAAAGCCATCAATAGTGAGATTGTTTGATGATCTTGCAGAAAAGATTCATAGGCAGTATGAAACAATTGGCTTGGACTTCACAATT
CCAAAGTCATGTGTTGAAATAGCGGAATTACTTCAACAGTCAAAAAACCCCTCTATCAACCAGATATTGCTTAGCCCAGAAAAAATTAAG
GAAGGAATTAAACGCCAACAGGAAAAGAATGCCGATGCCCTAAGGAACTATGAAAATTTGGTAGACACCTTGCTAGATGGTGTGGAGCAA
AGAAACCTGCCCTGGAAATTTGAACATATAGGCATTGGGCTTCTGTCTCTACTGCTGAGAGATGACCGAGTGTTGCCTCTTCGTGCCATA
CGGTTTTTTGTTGAGAATCTCAACCATGATGCAATTGTAGTTCGAAAGATGGCTATCTCAGCTGTTGCTGGTATCCTTAAACAGCTAAAA
AGAACCCACAAAAAGCTGACCATTAACCCCTGTGAAATCAGTGGATGCCCTAAACCCACCCAAATTATTGCTGGTGATAGGCCTGATAAT
CATTGGTTGCATTATGACAGCAAAACTATACCAAGAACTAAAAAAGAATGGGAGTCAAGTTGCTTTGTGGAAAAAACTCACTGGGGATAC
TACACCTGGCCAAAGAATATGGTTGTTTATGCTGGTGTGGAAGAGCAGCCTAAGCTTGGCAGAAGCAGGGAGGATATGACAGAGGCAGAA
CAGATTATATTTGATCATTTTTCTGATCCTAAATTTGTTGAGCAGTTAATTACTTTTCTATCATTAGAAGACAGAAAAGGAAAAGATAAG
TTTAATCCACGACGTTTTTGCCTCTTTAAGGGTATATTCAGGAATTTTGATGATGCCTTCCTGCCAGTTCTGAAGCCCCATTTAGAACAT
TTGGTTGCAGATTCACATGAAAGCACCCAGCGATGTGTTGCAGAAATTATAGCTGGTTTAATCAGAGGTTCTAAGCACTGGACATTTGAA
AAGGTGGAGAAGCTTTGGGAGCTTCTGTGCCCTCTGCTTAGAACAGCACTGTCCAATATTACCGTAGAAACTTATAATGACTGGGGAGCT
TGTATAGCAACATCCTGTGAAAGCAGAGATCCCCGGAAACTTCACTGGCTTTTTGAACTGCTGTTGGAATCACCATTGAGTGGTGAAGGA
GGATCCTTTGTAGATGCATGTCGACTTTATGTACTACAAGGTGGCCTTGCCCAGCAAGAATGGAGAGTGCCTGAACTATTGCACAGACTA
CTGAAGTACTTGGAACCCAAACTCACCCAGGTTTACAAAAATGTCAGAGAAAGAATAGGAAGTGTGCTGACCTACATATTCATGATAGAT
GTATCTTTGCCAAATACCACACCAACCATATCGCCTCATGTCCCTGAGTTTACTGCTCGAATTCTGGAGAAATTGAAACCTCTCATGGAT
GTGGATGAAGAAATTCAGAACCATGTTATGGAAGAAAATGGAATTGGTGAAGAAGATGAGCGAACTCAGGGCATTAAACTCTTGAAAACC
ATATTGAAATGGCTGATGGCAAGTGCAGGAAGATCCTTTTCTACAGCAGTTACAGAACAACTTCAGCTTCTACCTTTGTTTTTCAAGATT
GCCCCAGTGGAAAATGACAATAGCTACGATGAACTGAAAAGAGATGCAAAGTTATGTTTATCATTAATGTCTCAGGGGTTGCTTTACCCT
CATCAAGTGCCTTTGGTACTTCAGGTGCTAAAACAAACAGCAAGAAGCAGTTCTTGGCATGCACGATACACAGTACTGACCTACCTCCAG
ACCATGGTATTTTATAACCTCTTTATTTTCCTAAACAATGAAGATGCAGTTAAAGATATCAGGTGGCTGGTTATAAGTCTTTTGGAGGAC
GAACAACTGGAGATTCCAGAGAGTCCTCTATTTCATATGTGCCTTCCAGAACATCTCTTGTGGTATTCACTACTTGGCTTCTGTGTTCAT
GGGAGTCACCCCTCATCATGTCTGCAGGCCCCCAGGCAATGTGAGTCAGGTTGTTTTCCATAATCACTCTAATTGGAGTTTGGAGGACAC
CGGGGCCCTGTTGTCTTCAGGCCAGAAAGATTATGTTACGGTGCAGTTGCAGAATGGTGAGATCTGGGAGCTCTCAAGGTGTAGCAGGAA
TAAGAGGGAGAACACATCGAGTTTGGGCTATGAATACACTGGCAGTAAGAAAGAGTTTCCTTGTGTGGATGGCTACATATATGACCAGAA
CACATGGAAAAGCACTGCGGTGACCCAGTGGAACCTGGTCTGTGACCGAAAATGGCTTGCAATGCTGATCCAGCCCCTATTTATGTTTGG
AGTCCTACTGGGATCGGTGACTTTTGGCTACTTTTCTGACAGAGTAGGCTTCCTAACTGCTTGGTACAAAACCAGTGGATTCCCCACATC
CAGTGCTCCTCCTCTCTAATTCAACCCACTATCTGTGAAGTGTCATCTGGACTCATTGTGGGACTTGGGGATTAGAGGACCTGAGACAAA
GATGCTGCTGCCCTACTGCTTGCTAACGAAGCTAGGACGCCGGGTGGTCTTGTGGGCCACAAGCAGTAGCATGTTTTTGTTTGGAATAGC
AGCGGCGTTTGCAGTTGATTATTACACCTTCATGGCTGCTCGCTTTTTTCTTGCCATGGTTGCAAGTGGCTATCTTGTGGTGGGGTTTGT
CTATGTGATGGAATTCATTGGCATGAAGTCTCGGACATGGGCGTCTGTCCATTTGCATTCCTTTTTTGCAGTTGGAACCCTGCTGGTGGC
TTTGACAGGATACTTGGTCAGGACCTGGTGGCTTTACCAGATGATCCTCTCCACAGTGACTGTCCCCTTTATCCTGTGCTGTTGGGTGCT
CCCAGAGACACCTTTTTGGCTTCTCTCAGAGGGACGATATGAAGAAGCACAAAAAATAGTTGACATCATGGCCAAGTGGAACAGGGCAAG

>69758_69758_2_PSME4-SLC22A16_PSME4_chr2_54101476_ENST00000421748_SLC22A16_chr6_110778220_ENST00000456137_length(amino acids)=890AA_BP=842
MGENLAKKIMFFLLTIKLILNHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVML
QHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVTQQQFKGALYCLLGNHS
GVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIK
EGIKRQQEKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLK
RTHKKLTINPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTKKEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAE
QIIFDHFSDPKFVEQLITFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHESTQRCVAEIIAGLIRGSKHWTFE
KVEKLWELLCPLLRTALSNITVETYNDWGACIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRL
LKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTTPTISPHVPEFTARILEKLKPLMDVDEEIQNHVMEENGIGEEDERTQGIKLLKT
ILKWLMASAGRSFSTAVTEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHARYTVLTYLQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PSME4-SLC22A16

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PSME4-SLC22A16

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PSME4-SLC22A16

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source