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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMG2-SETMAR (FusionGDB2 ID:69767)

Fusion Gene Summary for PSMG2-SETMAR

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMG2-SETMAR
Fusion gene ID: 69767
HgeneTgene
Gene symbol

PSMG2

SETMAR

Gene ID

56984

6419

Gene nameproteasome assembly chaperone 2SET domain and mariner transposase fusion gene
SynonymsCLAST3|HCCA3|HsT1707|MDS003|PAC2|TNFSF5IP1METNASE|Mar1
Cytomap

18p11.21

3p26.1

Type of geneprotein-codingprotein-coding
Descriptionproteasome assembly chaperone 2CD40 ligand-activated specific transcript 3HDCMC29PHSPC260PAC-2hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-susceptibility protein 3likely ortholog of mouse CD40 ligand-activated specific trhistone-lysine N-methyltransferase SETMARSET domain and mariner transposase fusion gene-containing proteinSET domain and mariner transposase fusion protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317615, ENST00000585331, 
ENST00000590217, ENST00000589405, 
ENST00000462115, ENST00000425863, 
ENST00000430981, ENST00000358065, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 3 X 2=12
# samples 53
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMG2 [Title/Abstract] AND SETMAR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMG2(12706720)-SETMAR(4354582), # samples:3
Anticipated loss of major functional domain due to fusion event.PSMG2-SETMAR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PSMG2-SETMAR seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePSMG2

GO:0043248

proteasome assembly

16251969

TgeneSETMAR

GO:0000729

DNA double-strand break processing

21491884

TgeneSETMAR

GO:0000737

DNA catabolic process, endonucleolytic

20521842|21491884

TgeneSETMAR

GO:0006303

double-strand break repair via nonhomologous end joining

16332963

TgeneSETMAR

GO:0010452

histone H3-K36 methylation

16332963

TgeneSETMAR

GO:0051568

histone H3-K4 methylation

16332963

TgeneSETMAR

GO:2000373

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

18790802

TgeneSETMAR

GO:2001034

positive regulation of double-strand break repair via nonhomologous end joining

20620605|21491884

TgeneSETMAR

GO:2001251

negative regulation of chromosome organization

20620605


check buttonFusion gene breakpoints across PSMG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SETMAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9L2-01APSMG2chr18

12706720

-SETMARchr3

4354582

+
ChimerDB4PRADTCGA-ZG-A9L2-01APSMG2chr18

12706720

+SETMARchr3

4354582

+
ChimerDB4PRADTCGA-ZG-A9L2PSMG2chr18

12706720

+SETMARchr3

4354582

+
ChimerDB4PRADTCGA-ZG-A9L2PSMG2chr18

12706720

+SETMARchr3

4355351

+
ChimerDB4PRADTCGA-ZG-A9L2PSMG2chr18

12706720

+SETMARchr3

4357896

+


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Fusion Gene ORF analysis for PSMG2-SETMAR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000317615ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4354582

+
5CDS-3UTRENST00000585331ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4354582

+
5CDS-3UTRENST00000590217ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4354582

+
5CDS-intronENST00000317615ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000317615ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000317615ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4355351

+
5CDS-intronENST00000317615ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000585331ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000585331ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000585331ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4355351

+
5CDS-intronENST00000585331ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000590217ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000590217ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4357896

+
5CDS-intronENST00000590217ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4355351

+
5CDS-intronENST00000590217ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4357896

+
Frame-shiftENST00000317615ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4354582

+
Frame-shiftENST00000317615ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4355351

+
Frame-shiftENST00000317615ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4357896

+
Frame-shiftENST00000317615ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4354582

+
Frame-shiftENST00000317615ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4355351

+
Frame-shiftENST00000585331ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4354582

+
Frame-shiftENST00000585331ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4355351

+
Frame-shiftENST00000585331ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4357896

+
Frame-shiftENST00000585331ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4354582

+
Frame-shiftENST00000585331ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4355351

+
Frame-shiftENST00000590217ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4354582

+
Frame-shiftENST00000590217ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4355351

+
Frame-shiftENST00000590217ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4357896

+
Frame-shiftENST00000590217ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4354582

+
Frame-shiftENST00000590217ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4355351

+
In-frameENST00000317615ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4354582

+
In-frameENST00000317615ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4355351

+
In-frameENST00000585331ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4354582

+
In-frameENST00000585331ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4355351

+
In-frameENST00000590217ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4354582

+
In-frameENST00000590217ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4355351

+
intron-3CDSENST00000589405ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4354582

+
intron-3CDSENST00000589405ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4355351

+
intron-3CDSENST00000589405ENST00000358065PSMG2chr18

12706720

+SETMARchr3

4357896

+
intron-3CDSENST00000589405ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4354582

+
intron-3CDSENST00000589405ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4355351

+
intron-3CDSENST00000589405ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4354582

+
intron-3CDSENST00000589405ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4355351

+
intron-3UTRENST00000589405ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4354582

+
intron-intronENST00000589405ENST00000425863PSMG2chr18

12706720

+SETMARchr3

4357896

+
intron-intronENST00000589405ENST00000430981PSMG2chr18

12706720

+SETMARchr3

4357896

+
intron-intronENST00000589405ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4355351

+
intron-intronENST00000589405ENST00000462115PSMG2chr18

12706720

+SETMARchr3

4357896

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585331PSMG2chr1812706720+ENST00000430981SETMARchr34354582+17132081991149316
ENST00000317615PSMG2chr1812706720+ENST00000430981SETMARchr34354582+24169119021852316
ENST00000590217PSMG2chr1812706720+ENST00000430981SETMARchr34354582+18193143051255316
ENST00000585331PSMG2chr1812706720+ENST00000430981SETMARchr34355351+943208329396
ENST00000317615PSMG2chr1812706720+ENST00000430981SETMARchr34355351+1646911376996206
ENST00000590217PSMG2chr1812706720+ENST00000430981SETMARchr34355351+104931425399124

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585331ENST00000430981PSMG2chr1812706720+SETMARchr34354582+0.0003708520.99962914
ENST00000317615ENST00000430981PSMG2chr1812706720+SETMARchr34354582+0.0011021150.9988979
ENST00000590217ENST00000430981PSMG2chr1812706720+SETMARchr34354582+0.0003547590.99964523
ENST00000585331ENST00000430981PSMG2chr1812706720+SETMARchr34355351+0.146236670.85376334
ENST00000317615ENST00000430981PSMG2chr1812706720+SETMARchr34355351+0.0199823120.98001766
ENST00000590217ENST00000430981PSMG2chr1812706720+SETMARchr34355351+0.0230188760.9769811

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Fusion Genomic Features for PSMG2-SETMAR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSMG2chr1812706720+SETMARchr34357895+3.89E-050.99996114
PSMG2chr1812706720+SETMARchr34354581+1.77E-060.9999982
PSMG2chr1812706720+SETMARchr34354581+1.77E-060.9999982
PSMG2chr1812706720+SETMARchr34357895+3.89E-050.99996114
PSMG2chr1812706720+SETMARchr34354581+1.77E-060.9999982
PSMG2chr1812706720+SETMARchr34354581+1.77E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PSMG2-SETMAR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:12706720/chr3:4354582)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503364_39552685.0DNA bindingH-T-H motif
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503428_44852685.0DNA bindingNote=H-T-H motif
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503364_3950685.0DNA bindingH-T-H motif
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503428_4480685.0DNA bindingNote=H-T-H motif
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503139_26352685.0DomainSET
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503283_29952685.0DomainPost-SET
TgeneSETMARchr18:12706720chr3:4354582ENST000003580650373_13652685.0DomainPre-SET
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503139_2630685.0DomainSET
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503283_2990685.0DomainPost-SET
TgeneSETMARchr18:12706720chr3:4355351ENST000003580650373_1360685.0DomainPre-SET
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503149_15152685.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503223_22452685.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETMARchr18:12706720chr3:4354582ENST0000035806503346_68452685.0RegionNote=Mariner transposase Hsmar1
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503149_1510685.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETMARchr18:12706720chr3:4355351ENST00000358065031_3450685.0RegionNote=Histone-lysine N-methyltransferase
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503223_2240685.0RegionNote=S-adenosyl-L-methionine binding
TgeneSETMARchr18:12706720chr3:4355351ENST0000035806503346_6840685.0RegionNote=Mariner transposase Hsmar1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSETMARchr18:12706720chr3:4354582ENST00000358065031_34552685.0RegionNote=Histone-lysine N-methyltransferase


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Fusion Gene Sequence for PSMG2-SETMAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69767_69767_1_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000317615_SETMAR_chr3_4354582_ENST00000430981_length(transcript)=2416nt_BP=911nt
GGCAGGAGGGAAAGGTTATGGGTCGGCCCGGCGGTCTCTCCCAGCACCCGCGACTCTCACCTTGCTCAGCTGCTGGTGGATGAGCTGCTT
CAGCTCGGAGGCTTTCTCCGGAGGCAGCGACATGCTGGCAGCCGGCGTCTCCCCGCCGCTTCTCCCCGCCTCAGATGCCCTAACTGCGCG
GCCCCGGCCGGGCCAGGGAGCGTTAGGAGCGACTGGAGCACAAAGCGCCGCAGCCGTTCGCCTAGCGCAGCTCCCGGGGGACGCAACGCC
GCGTCAGGCCGGGGGCTGACCTGGAAATGAGGCCCCGGCGGCGGCGGCGCCAACTGTTTTCAAACAGTGGCGGACAAACAGGGCTTGGGG
CTGGCCCGCACGCTGCCTGATCGTTTCCGCCCGCCGCTCCACCTCCCCGCGGGCCCCGCACCCCGAGACCTCAGCGCACCCCATCGCCTT
GCTTGCCAGGGTCTCCGAAAGCGCTGCTGGCCCCTCTTCGCGGCCACCCGGCGGCCTCTTTCCGCCCTCTGAACCGGCAGTTAGCTGGAC
GGGCCTCAAGGGCCCGGCGCCCAGGGACTCAAAGGACCCTCCCGCGCCCCGCGAGGCTCCGGGGTCTCGGGCTTCCGCCTTCTTGCTGCC
CTCGTTCTTGCCAGGGCCGCGGTTAGTCCCTGCTGGCCACCCCACTGCGACCATGTTCGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGC
CGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAATGGATCTGATTATTTCTACACTGAATATGTCTAA
GATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGCGACCACAGAAGGAAATTCAACAGAACTTAGCAT
AAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCA
AAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAG
GAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGT
TCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATG
CTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACATTATAGCCATCAGGGAAC
ATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAA
ACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCT
CTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACT
GTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGA
AGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGC
TTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTACATAAGTTTAACTCAGGAATGTGGCAGAGACTGC
AAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAAGTACATGACTACCCAGAATACTCACTTTCCTAG
TTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTCCTTAAATGGAGATATCCTGCCCTTCACCTCCTC
TTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTAGACCCCAGGATGACCCTGGGAAAGGAAGCCATT
GCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATCCTGTCAGTCGTGATCTGACACCTTTGTACTTTC
AGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCACTAACATCGAACCTAATAATGATCCAAGAAACCC

>69767_69767_1_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000317615_SETMAR_chr3_4354582_ENST00000430981_length(amino acids)=316AA_BP=1
MLKYTPDHVVGPGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQF
HFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPN
LLMIPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEK

--------------------------------------------------------------
>69767_69767_2_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000317615_SETMAR_chr3_4355351_ENST00000430981_length(transcript)=1646nt_BP=911nt
GGCAGGAGGGAAAGGTTATGGGTCGGCCCGGCGGTCTCTCCCAGCACCCGCGACTCTCACCTTGCTCAGCTGCTGGTGGATGAGCTGCTT
CAGCTCGGAGGCTTTCTCCGGAGGCAGCGACATGCTGGCAGCCGGCGTCTCCCCGCCGCTTCTCCCCGCCTCAGATGCCCTAACTGCGCG
GCCCCGGCCGGGCCAGGGAGCGTTAGGAGCGACTGGAGCACAAAGCGCCGCAGCCGTTCGCCTAGCGCAGCTCCCGGGGGACGCAACGCC
GCGTCAGGCCGGGGGCTGACCTGGAAATGAGGCCCCGGCGGCGGCGGCGCCAACTGTTTTCAAACAGTGGCGGACAAACAGGGCTTGGGG
CTGGCCCGCACGCTGCCTGATCGTTTCCGCCCGCCGCTCCACCTCCCCGCGGGCCCCGCACCCCGAGACCTCAGCGCACCCCATCGCCTT
GCTTGCCAGGGTCTCCGAAAGCGCTGCTGGCCCCTCTTCGCGGCCACCCGGCGGCCTCTTTCCGCCCTCTGAACCGGCAGTTAGCTGGAC
GGGCCTCAAGGGCCCGGCGCCCAGGGACTCAAAGGACCCTCCCGCGCCCCGCGAGGCTCCGGGGTCTCGGGCTTCCGCCTTCTTGCTGCC
CTCGTTCTTGCCAGGGCCGCGGTTAGTCCCTGCTGGCCACCCCACTGCGACCATGTTCGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGC
CGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAATGGATCTGATTATTTCTACACTGAATATGTCTAA
GATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGCGACCACAGAAGGAAATTCAACAGAACTTAGCAT
AAATGCTGAAGAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAG
CGATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCC
TAGTTACATAAGTTTAACTCAGGAATGTGGCAGAGACTGCAAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTT
AACAAAAGTACATGACTACCCAGAATACTCACTTTCCTAGTTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATG
ACAAGTCCTTAAATGGAGATATCCTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGT
CATCCTAGACCCCAGGATGACCCTGGGAAAGGAAGCCATTGCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTA
GAACATCCTGTCAGTCGTGATCTGACACCTTTGTACTTTCAGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTT
CTAGCACTAACATCGAACCTAATAATGATCCAAGAAACCCTTGTGGCTGCATACCTAAACCCTGCTTGCCAACCAATTTTAACAGTAATA

>69767_69767_2_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000317615_SETMAR_chr3_4355351_ENST00000430981_length(amino acids)=206AA_BP=179
MIVSARRSTSPRAPHPETSAHPIALLARVSESAAGPSSRPPGGLFPPSEPAVSWTGLKGPAPRDSKDPPAPREAPGSRASAFLLPSFLPG
PRLVPAGHPTATMFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEES

--------------------------------------------------------------
>69767_69767_3_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000585331_SETMAR_chr3_4354582_ENST00000430981_length(transcript)=1713nt_BP=208nt
TGGTTGAATACCTCCCTCTCCACTCCCATCTTCAGGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAATGGATCTGATTATTTCT
ACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGCGACCACAGAAGGAAAT
TCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCC
CGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAG
AGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGT
CCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAG
GTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACAT
TATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAA
TCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGT
GCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACT
AAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACAT
CAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGGTGAGTCT
GTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTACATAAGTTTAACTCAGG
AATGTGGCAGAGACTGCAAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAAGTACATGACTACCCAG
AATACTCACTTTCCTAGTTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTCCTTAAATGGAGATATC
CTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTAGACCCCAGGATGACCC
TGGGAAAGGAAGCCATTGCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATCCTGTCAGTCGTGATCT
GACACCTTTGTACTTTCAGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCACTAACATCGAACCTAAT
AATGATCCAAGAAACCCTTGTGGCTGCATACCTAAACCCTGCTTGCCAACCAATTTTAACAGTAATAAAGCTGACTTTTTGATTTCTGTC

>69767_69767_3_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000585331_SETMAR_chr3_4354582_ENST00000430981_length(amino acids)=316AA_BP=1
MLKYTPDHVVGPGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQF
HFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPN
LLMIPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEK

--------------------------------------------------------------
>69767_69767_4_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000585331_SETMAR_chr3_4355351_ENST00000430981_length(transcript)=943nt_BP=208nt
TGGTTGAATACCTCCCTCTCCACTCCCATCTTCAGGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAATGGATCTGATTATTTCT
ACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGCGACCACAGAAGGAAAT
TCAACAGAACTTAGCATAAATGCTGAAGAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTG
TGTTCCCCTCCTGCAAGCGATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGG
CTAGCTTTACCTCTGCCTAGTTACATAAGTTTAACTCAGGAATGTGGCAGAGACTGCAAGTTGTCCATCAGTATCCTTTCCCCTTTCTGT
AATAGAATTCTCCATTTAACAAAAGTACATGACTACCCAGAATACTCACTTTCCTAGTTAGATTTGTCTTAGTGACTGTTCTAGTTAATA
GGATATAAGCAAAAATGACAAGTCCTTAAATGGAGATATCCTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTGGAATGTATACATGATG
ACTGGAACTGGAGCAGTCATCCTAGACCCCAGGATGACCCTGGGAAAGGAAGCCATTGCATAGAAAAATCAACAAGGTTAAAAGGAGTCT
AGGTGTCTGGTACTGTAGAACATCCTGTCAGTCGTGATCTGACACCTTTGTACTTTCAGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCA
CTGTTATTGTAAGTTTTCTAGCACTAACATCGAACCTAATAATGATCCAAGAAACCCTTGTGGCTGCATACCTAAACCCTGCTTGCCAAC

>69767_69767_4_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000585331_SETMAR_chr3_4355351_ENST00000430981_length(amino acids)=96AA_BP=69
MNTSLSTPIFRPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEESRTSVVEMRRNPACVAQPLLC

--------------------------------------------------------------
>69767_69767_5_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000590217_SETMAR_chr3_4354582_ENST00000430981_length(transcript)=1819nt_BP=314nt
TCCGGGGTCTCGGGCTTCCGCCTTCTTGCTGCCCTCGTTCTTGCCAGGGCCGCGGTTAGTCCCTGCTGGCCACCCCACTGCGACCATGTT
CGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGCCGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAAT
GGATCTGATTATTTCTACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGC
GACCACAGAAGGAAATTCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCA
CTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATG
ATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACT
GCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAAT
TTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAAT
CCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATA
TTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTG
CAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGC
TAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCG
TAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGA
CCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTAC
ATAAGTTTAACTCAGGAATGTGGCAGAGACTGCAAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAA
GTACATGACTACCCAGAATACTCACTTTCCTAGTTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTC
CTTAAATGGAGATATCCTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTA
GACCCCAGGATGACCCTGGGAAAGGAAGCCATTGCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATC
CTGTCAGTCGTGATCTGACACCTTTGTACTTTCAGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCAC
TAACATCGAACCTAATAATGATCCAAGAAACCCTTGTGGCTGCATACCTAAACCCTGCTTGCCAACCAATTTTAACAGTAATAAAGCTGA

>69767_69767_5_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000590217_SETMAR_chr3_4354582_ENST00000430981_length(amino acids)=316AA_BP=1
MLKYTPDHVVGPGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQF
HFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPN
LLMIPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEK

--------------------------------------------------------------
>69767_69767_6_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000590217_SETMAR_chr3_4355351_ENST00000430981_length(transcript)=1049nt_BP=314nt
TCCGGGGTCTCGGGCTTCCGCCTTCTTGCTGCCCTCGTTCTTGCCAGGGCCGCGGTTAGTCCCTGCTGGCCACCCCACTGCGACCATGTT
CGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGCCGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAAT
GGATCTGATTATTTCTACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGC
GACCACAGAAGGAAATTCAACAGAACTTAGCATAAATGCTGAAGAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGT
GGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGT
GGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTACATAAGTTTAACTCAGGAATGTGGCAGAGACTGCAAGTTGTCCATCAGTAT
CCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAAGTACATGACTACCCAGAATACTCACTTTCCTAGTTAGATTTGTCTTAGTG
ACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTCCTTAAATGGAGATATCCTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTG
GAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTAGACCCCAGGATGACCCTGGGAAAGGAAGCCATTGCATAGAAAAATCAACA
AGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATCCTGTCAGTCGTGATCTGACACCTTTGTACTTTCAGGTGAGAAATAGTCTC
TCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCACTAACATCGAACCTAATAATGATCCAAGAAACCCTTGTGGCTGCATACCTA

>69767_69767_6_PSMG2-SETMAR_PSMG2_chr18_12706720_ENST00000590217_SETMAR_chr3_4355351_ENST00000430981_length(amino acids)=124AA_BP=97
MLPSFLPGPRLVPAGHPTATMFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PSMG2-SETMAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMG2-SETMAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMG2-SETMAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource