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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMG4-DUSP22 (FusionGDB2 ID:69771)

Fusion Gene Summary for PSMG4-DUSP22

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMG4-DUSP22
Fusion gene ID: 69771
HgeneTgene
Gene symbol

PSMG4

DUSP22

Gene ID

389362

56940

Gene nameproteasome assembly chaperone 4dual specificity phosphatase 22
SynonymsC6orf86|PAC4|bA506K6.2JKAP|JSP-1|JSP1|LMW-DSP2|LMWDSP2|MKP-x|MKPX|VHX
Cytomap

6p25.2

6p25.3

Type of geneprotein-codingprotein-coding
Descriptionproteasome assembly chaperone 4PAC-4hPAC4proteasome (prosome, macropain) assembly chaperone 4dual specificity protein phosphatase 22JNK-stimulating phosphatase 1JNK-stimulatory phosphatase-1MAP kinase phosphatase xepididymis secretory sperm binding proteinhomolog of mouse dual specificity phosphatase LMW-DSP2low molecular weight dual specif
Modification date2020031320200313
UniProtAcc.

Q9NRW4

Ensembl transtripts involved in fusion geneENST00000380305, ENST00000419065, 
ENST00000438998, ENST00000451246, 
ENST00000473000, ENST00000380306, 
ENST00000416079, 		ENST00000603453, 
ENST00000605035, ENST00000419235, 
ENST00000603290, ENST00000604971, 
ENST00000605315, ENST00000605863, 
ENST00000344450, 
Fusion gene scores* DoF score4 X 2 X 3=245 X 4 X 3=60
# samples 55
** MAII scorelog2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMG4 [Title/Abstract] AND DUSP22 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMG4(3259430)-DUSP22(304628), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDUSP22

GO:0035335

peptidyl-tyrosine dephosphorylation

20018849

TgeneDUSP22

GO:0051895

negative regulation of focal adhesion assembly

20018849

TgeneDUSP22

GO:0071364

cellular response to epidermal growth factor stimulus

20018849


check buttonFusion gene breakpoints across PSMG4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DUSP22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACA453928PSMG4chr6

3259430

+DUSP22chr6

304628

+


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Fusion Gene ORF analysis for PSMG4-DUSP22

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000380305ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000380305ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000419065ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000419065ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000438998ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000438998ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000451246ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000451246ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000473000ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-5UTRENST00000473000ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000380305ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000380305ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000380305ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000380305ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000380305ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000419065ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000419065ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000419065ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000419065ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000419065ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000438998ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000438998ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000438998ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000438998ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000438998ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000451246ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000451246ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000451246ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000451246ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000451246ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000473000ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000473000ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000473000ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000473000ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
5CDS-intronENST00000473000ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+
In-frameENST00000380305ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
In-frameENST00000419065ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
In-frameENST00000438998ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
In-frameENST00000451246ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
In-frameENST00000473000ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-3CDSENST00000380306ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-3CDSENST00000416079ENST00000344450PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-5UTRENST00000380306ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-5UTRENST00000380306ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-5UTRENST00000416079ENST00000603453PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-5UTRENST00000416079ENST00000605035PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000380306ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000380306ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000380306ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000380306ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000380306ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000416079ENST00000419235PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000416079ENST00000603290PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000416079ENST00000604971PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000416079ENST00000605315PSMG4chr6

3259430

+DUSP22chr6

304628

+
intron-intronENST00000416079ENST00000605863PSMG4chr6

3259430

+DUSP22chr6

304628

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000451246PSMG4chr63259430+ENST00000344450DUSP22chr6304628+123421339746235
ENST00000438998PSMG4chr63259430+ENST00000344450DUSP22chr6304628+1324303129836235
ENST00000380305PSMG4chr63259430+ENST00000344450DUSP22chr6304628+1321300126833235
ENST00000419065PSMG4chr63259430+ENST00000344450DUSP22chr6304628+126624571778235
ENST00000473000PSMG4chr63259430+ENST00000344450DUSP22chr6304628+125723662769235

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451246ENST00000344450PSMG4chr63259430+DUSP22chr6304628+0.0049476760.9950524
ENST00000438998ENST00000344450PSMG4chr63259430+DUSP22chr6304628+0.006523420.99347657
ENST00000380305ENST00000344450PSMG4chr63259430+DUSP22chr6304628+0.0061668060.9938332
ENST00000419065ENST00000344450PSMG4chr63259430+DUSP22chr6304628+0.0050863680.9949136
ENST00000473000ENST00000344450PSMG4chr63259430+DUSP22chr6304628+0.0053301830.99466985

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Fusion Genomic Features for PSMG4-DUSP22


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSMG4chr63259430+DUSP22chr6304627+0.36495090.63504916
PSMG4chr63259430+DUSP22chr6304627+0.36495090.63504916

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PSMG4-DUSP22


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:3259430/chr6:304628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DUSP22

Q9NRW4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). {ECO:0000250, ECO:0000269|PubMed:11717427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDUSP22chr6:3259430chr6:304628ENST00000344450084_1447185.0DomainTyrosine-protein phosphatase
TgeneDUSP22chr6:3259430chr6:304628ENST00000419235074_1447206.0DomainTyrosine-protein phosphatase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PSMG4-DUSP22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69771_69771_1_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000380305_DUSP22_chr6_304628_ENST00000344450_length(transcript)=1321nt_BP=300nt
CCCGCCCTTCCGGGGCCGAAAGCGAAAGCGCGCTCGGTCTCTCGGTGCTCGCTCCATCGGGTCTGGCGGGGCTGGCAGCGGCGAGGACCC
GGGTCTGGCGCTGTGGGCCGGGAGCCGTGGGGCGGCATGGAGGGGCTGGTTGTCGCCGCCGGCGGGGACGTCTCCCTGCACAACTTCAGC
GCGAGGCTGTGGGAGCAGCTGGTCCACTTCCACGTCATGCGGCTGACGGACTCGCTGTTCCTGTGGGTGGGGGCCACGCCGCACCTGCGC
AACCTCGCCGTGGCCATGTGCAGCCGCTACATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGC
AAGAACAAGGTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGGGAGTTAAATACCTGTGCATCCCAGCAGCGGAT
TCACCATCTCAAAACCTGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACGAGTGCCGGCTCCGCGGTGAGAGCTGCCTTGTACAC
TGCCTGGCCGGGGTCTCCAGGAGCGTGACACTGGTGATCGCATACATCATGACCGTCACTGACTTTGGCTGGGAGGATGCCCTGCACACC
GTGCGTGCTGGGAGATCCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCCAGGAGTTTGAGAAGCATGAGGTCCATCAGTATCGG
CAGTGGCTGAAGGAAGAATATGGAGAGAGCCCTTTGCAGGATGCAGAAGAAGCCAAAAACATTCTGGCCGCTCCGGGAATTCTGAAGTTC
TGGGCCTTTCTCAGAAGACTGTAATGTACCTGAAGTTTCTGAAATATTGCAAACCCACAGAGTTTAGGCTGGTGCTGCCAAAAAGAAAAG
CAACATAGAGTTTAAGTATCCAGTAGTGATTTGTAAACTTGTTTTTCATTTGAAGCTGAATATATACGTAGTCATGTTTATGTTGAGAAC
TAAGGATATTCTTTAGCAAGAGAAAATATTTTCCCCTTATCCCCACTGCTGTGGAGGTTTCTGTACCTCGCTTGGATGCCTGTAAGGATC
CCGGGAGCCTTGCCGCACTGCCTTGTGGGTGGCTTGGCGCTCGTGATTGCTTCCTGTGAACGCCTCCCAAGGACGAGCCCAGTGTAGTTG
TGTGGCGTGAACTCTGCCCGTGTGTTCTCAAATTCCCCAGCTTGGGAAATAGCCCTTGGTGTGGGTTTTATCTCTGGTTTGTGTTCTCCG

>69771_69771_1_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000380305_DUSP22_chr6_304628_ENST00000344450_length(amino acids)=235AA_BP=58
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYILPGLYIGNFKDARDAEQLSKNKVTHILSVHD
SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNV

--------------------------------------------------------------
>69771_69771_2_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000419065_DUSP22_chr6_304628_ENST00000344450_length(transcript)=1266nt_BP=245nt
ATCGGGTCTGGCGGGGCTGGCAGCGGCGAGGACCCGGGTCTGGCGCTGTGGGCCGGGAGCCGTGGGGCGGCATGGAGGGGCTGGTTGTCG
CCGCCGGCGGGGACGTCTCCCTGCACAACTTCAGCGCGAGGCTGTGGGAGCAGCTGGTCCACTTCCACGTCATGCGGCTGACGGACTCGC
TGTTCCTGTGGGTGGGGGCCACGCCGCACCTGCGCAACCTCGCCGTGGCCATGTGCAGCCGCTACATCCTGCCCGGCCTGTACATCGGCA
ACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGG
AGGGAGTTAAATACCTGTGCATCCCAGCAGCGGATTCACCATCTCAAAACCTGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACG
AGTGCCGGCTCCGCGGTGAGAGCTGCCTTGTACACTGCCTGGCCGGGGTCTCCAGGAGCGTGACACTGGTGATCGCATACATCATGACCG
TCACTGACTTTGGCTGGGAGGATGCCCTGCACACCGTGCGTGCTGGGAGATCCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCC
AGGAGTTTGAGAAGCATGAGGTCCATCAGTATCGGCAGTGGCTGAAGGAAGAATATGGAGAGAGCCCTTTGCAGGATGCAGAAGAAGCCA
AAAACATTCTGGCCGCTCCGGGAATTCTGAAGTTCTGGGCCTTTCTCAGAAGACTGTAATGTACCTGAAGTTTCTGAAATATTGCAAACC
CACAGAGTTTAGGCTGGTGCTGCCAAAAAGAAAAGCAACATAGAGTTTAAGTATCCAGTAGTGATTTGTAAACTTGTTTTTCATTTGAAG
CTGAATATATACGTAGTCATGTTTATGTTGAGAACTAAGGATATTCTTTAGCAAGAGAAAATATTTTCCCCTTATCCCCACTGCTGTGGA
GGTTTCTGTACCTCGCTTGGATGCCTGTAAGGATCCCGGGAGCCTTGCCGCACTGCCTTGTGGGTGGCTTGGCGCTCGTGATTGCTTCCT
GTGAACGCCTCCCAAGGACGAGCCCAGTGTAGTTGTGTGGCGTGAACTCTGCCCGTGTGTTCTCAAATTCCCCAGCTTGGGAAATAGCCC
TTGGTGTGGGTTTTATCTCTGGTTTGTGTTCTCCGTGGTGGAATTGACCGAAAGCTCTATGTTTTCGTTAATAAAGGGCAACTTAGCCAA

>69771_69771_2_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000419065_DUSP22_chr6_304628_ENST00000344450_length(amino acids)=235AA_BP=58
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYILPGLYIGNFKDARDAEQLSKNKVTHILSVHD
SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNV

--------------------------------------------------------------
>69771_69771_3_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000438998_DUSP22_chr6_304628_ENST00000344450_length(transcript)=1324nt_BP=303nt
ACCCCCGCCCTTCCGGGGCCGAAAGCGAAAGCGCGCTCGGTCTCTCGGTGCTCGCTCCATCGGGTCTGGCGGGGCTGGCAGCGGCGAGGA
CCCGGGTCTGGCGCTGTGGGCCGGGAGCCGTGGGGCGGCATGGAGGGGCTGGTTGTCGCCGCCGGCGGGGACGTCTCCCTGCACAACTTC
AGCGCGAGGCTGTGGGAGCAGCTGGTCCACTTCCACGTCATGCGGCTGACGGACTCGCTGTTCCTGTGGGTGGGGGCCACGCCGCACCTG
CGCAACCTCGCCGTGGCCATGTGCAGCCGCTACATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTG
AGCAAGAACAAGGTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGGGAGTTAAATACCTGTGCATCCCAGCAGCG
GATTCACCATCTCAAAACCTGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACGAGTGCCGGCTCCGCGGTGAGAGCTGCCTTGTA
CACTGCCTGGCCGGGGTCTCCAGGAGCGTGACACTGGTGATCGCATACATCATGACCGTCACTGACTTTGGCTGGGAGGATGCCCTGCAC
ACCGTGCGTGCTGGGAGATCCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCCAGGAGTTTGAGAAGCATGAGGTCCATCAGTAT
CGGCAGTGGCTGAAGGAAGAATATGGAGAGAGCCCTTTGCAGGATGCAGAAGAAGCCAAAAACATTCTGGCCGCTCCGGGAATTCTGAAG
TTCTGGGCCTTTCTCAGAAGACTGTAATGTACCTGAAGTTTCTGAAATATTGCAAACCCACAGAGTTTAGGCTGGTGCTGCCAAAAAGAA
AAGCAACATAGAGTTTAAGTATCCAGTAGTGATTTGTAAACTTGTTTTTCATTTGAAGCTGAATATATACGTAGTCATGTTTATGTTGAG
AACTAAGGATATTCTTTAGCAAGAGAAAATATTTTCCCCTTATCCCCACTGCTGTGGAGGTTTCTGTACCTCGCTTGGATGCCTGTAAGG
ATCCCGGGAGCCTTGCCGCACTGCCTTGTGGGTGGCTTGGCGCTCGTGATTGCTTCCTGTGAACGCCTCCCAAGGACGAGCCCAGTGTAG
TTGTGTGGCGTGAACTCTGCCCGTGTGTTCTCAAATTCCCCAGCTTGGGAAATAGCCCTTGGTGTGGGTTTTATCTCTGGTTTGTGTTCT

>69771_69771_3_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000438998_DUSP22_chr6_304628_ENST00000344450_length(amino acids)=235AA_BP=58
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYILPGLYIGNFKDARDAEQLSKNKVTHILSVHD
SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNV

--------------------------------------------------------------
>69771_69771_4_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000451246_DUSP22_chr6_304628_ENST00000344450_length(transcript)=1234nt_BP=213nt
CCCGGGTCTGGCGCTGTGGGCCGGGAGCCGTGGGGCGGCATGGAGGGGCTGGTTGTCGCCGCCGGCGGGGACGTCTCCCTGCACAACTTC
AGCGCGAGGCTGTGGGAGCAGCTGGTCCACTTCCACGTCATGCGGCTGACGGACTCGCTGTTCCTGTGGGTGGGGGCCACGCCGCACCTG
CGCAACCTCGCCGTGGCCATGTGCAGCCGCTACATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTG
AGCAAGAACAAGGTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGGGAGTTAAATACCTGTGCATCCCAGCAGCG
GATTCACCATCTCAAAACCTGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACGAGTGCCGGCTCCGCGGTGAGAGCTGCCTTGTA
CACTGCCTGGCCGGGGTCTCCAGGAGCGTGACACTGGTGATCGCATACATCATGACCGTCACTGACTTTGGCTGGGAGGATGCCCTGCAC
ACCGTGCGTGCTGGGAGATCCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCCAGGAGTTTGAGAAGCATGAGGTCCATCAGTAT
CGGCAGTGGCTGAAGGAAGAATATGGAGAGAGCCCTTTGCAGGATGCAGAAGAAGCCAAAAACATTCTGGCCGCTCCGGGAATTCTGAAG
TTCTGGGCCTTTCTCAGAAGACTGTAATGTACCTGAAGTTTCTGAAATATTGCAAACCCACAGAGTTTAGGCTGGTGCTGCCAAAAAGAA
AAGCAACATAGAGTTTAAGTATCCAGTAGTGATTTGTAAACTTGTTTTTCATTTGAAGCTGAATATATACGTAGTCATGTTTATGTTGAG
AACTAAGGATATTCTTTAGCAAGAGAAAATATTTTCCCCTTATCCCCACTGCTGTGGAGGTTTCTGTACCTCGCTTGGATGCCTGTAAGG
ATCCCGGGAGCCTTGCCGCACTGCCTTGTGGGTGGCTTGGCGCTCGTGATTGCTTCCTGTGAACGCCTCCCAAGGACGAGCCCAGTGTAG
TTGTGTGGCGTGAACTCTGCCCGTGTGTTCTCAAATTCCCCAGCTTGGGAAATAGCCCTTGGTGTGGGTTTTATCTCTGGTTTGTGTTCT

>69771_69771_4_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000451246_DUSP22_chr6_304628_ENST00000344450_length(amino acids)=235AA_BP=58
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYILPGLYIGNFKDARDAEQLSKNKVTHILSVHD
SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNV

--------------------------------------------------------------
>69771_69771_5_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000473000_DUSP22_chr6_304628_ENST00000344450_length(transcript)=1257nt_BP=236nt
GGCGGGGCTGGCAGCGGCGAGGACCCGGGTCTGGCGCTGTGGGCCGGGAGCCGTGGGGCGGCATGGAGGGGCTGGTTGTCGCCGCCGGCG
GGGACGTCTCCCTGCACAACTTCAGCGCGAGGCTGTGGGAGCAGCTGGTCCACTTCCACGTCATGCGGCTGACGGACTCGCTGTTCCTGT
GGGTGGGGGCCACGCCGCACCTGCGCAACCTCGCCGTGGCCATGTGCAGCCGCTACATCCTGCCCGGCCTGTACATCGGCAACTTCAAAG
ATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGGGAGTTA
AATACCTGTGCATCCCAGCAGCGGATTCACCATCTCAAAACCTGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACGAGTGCCGGC
TCCGCGGTGAGAGCTGCCTTGTACACTGCCTGGCCGGGGTCTCCAGGAGCGTGACACTGGTGATCGCATACATCATGACCGTCACTGACT
TTGGCTGGGAGGATGCCCTGCACACCGTGCGTGCTGGGAGATCCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCCAGGAGTTTG
AGAAGCATGAGGTCCATCAGTATCGGCAGTGGCTGAAGGAAGAATATGGAGAGAGCCCTTTGCAGGATGCAGAAGAAGCCAAAAACATTC
TGGCCGCTCCGGGAATTCTGAAGTTCTGGGCCTTTCTCAGAAGACTGTAATGTACCTGAAGTTTCTGAAATATTGCAAACCCACAGAGTT
TAGGCTGGTGCTGCCAAAAAGAAAAGCAACATAGAGTTTAAGTATCCAGTAGTGATTTGTAAACTTGTTTTTCATTTGAAGCTGAATATA
TACGTAGTCATGTTTATGTTGAGAACTAAGGATATTCTTTAGCAAGAGAAAATATTTTCCCCTTATCCCCACTGCTGTGGAGGTTTCTGT
ACCTCGCTTGGATGCCTGTAAGGATCCCGGGAGCCTTGCCGCACTGCCTTGTGGGTGGCTTGGCGCTCGTGATTGCTTCCTGTGAACGCC
TCCCAAGGACGAGCCCAGTGTAGTTGTGTGGCGTGAACTCTGCCCGTGTGTTCTCAAATTCCCCAGCTTGGGAAATAGCCCTTGGTGTGG

>69771_69771_5_PSMG4-DUSP22_PSMG4_chr6_3259430_ENST00000473000_DUSP22_chr6_304628_ENST00000344450_length(amino acids)=235AA_BP=58
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYILPGLYIGNFKDARDAEQLSKNKVTHILSVHD
SARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNV

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Fusion Gene PPI Analysis for PSMG4-DUSP22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMG4-DUSP22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMG4-DUSP22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource