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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSORS1C1-OBSCN (FusionGDB2 ID:69776)

Fusion Gene Summary for PSORS1C1-OBSCN

check button Fusion gene summary
Fusion gene informationFusion gene name: PSORS1C1-OBSCN
Fusion gene ID: 69776
HgeneTgene
Gene symbol

PSORS1C1

OBSCN

Gene ID

170679

84033

Gene namepsoriasis susceptibility 1 candidate 1obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
SynonymsC6orf16|SEEK1ARHGEF30|UNC89
Cytomap

6p21.33

1q42.13

Type of geneprotein-codingprotein-coding
Descriptionpsoriasis susceptibility 1 candidate gene 1 proteinepididymis secretory sperm binding proteinobscurinobscurin, myosin light chain kinaseobscurin-MLCK
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000467107, ENST00000259881, 
ENST00000376289, ENST00000420214, 
ENST00000433334, ENST00000441092, 
ENST00000448455, ENST00000467097, 
ENST00000471399, ENST00000481450, 
ENST00000490397, ENST00000491367, 
ENST00000495389, ENST00000547221, 
ENST00000549149, 		ENST00000284548, 
ENST00000570156, ENST00000366707, 
ENST00000366709, ENST00000422127, 
ENST00000359599, ENST00000602685, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 7 X 5=280
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSORS1C1 [Title/Abstract] AND OBSCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSORS1C1(31082668)-OBSCN(228430884), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PSORS1C1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across OBSCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01APSORS1C1chr6

31082668

+OBSCNchr1

228430884

+


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Fusion Gene ORF analysis for PSORS1C1-OBSCN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000467107ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
3UTR-3CDSENST00000467107ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
3UTR-5UTRENST00000467107ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
3UTR-5UTRENST00000467107ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
3UTR-5UTRENST00000467107ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
3UTR-intronENST00000467107ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
3UTR-intronENST00000467107ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-3CDSENST00000259881ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-3CDSENST00000259881ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-5UTRENST00000259881ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-5UTRENST00000259881ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-5UTRENST00000259881ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-intronENST00000259881ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
5UTR-intronENST00000259881ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000376289ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000376289ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000420214ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000420214ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000433334ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000433334ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000441092ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000441092ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000448455ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000448455ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000467097ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000467097ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000471399ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000471399ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000481450ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000481450ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000490397ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000490397ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000491367ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000491367ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000495389ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000495389ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000547221ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000547221ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000549149ENST00000284548PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-3CDSENST00000549149ENST00000570156PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000376289ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000376289ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000376289ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000420214ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000420214ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000420214ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000433334ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000433334ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000433334ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000441092ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000441092ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000441092ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000448455ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000448455ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000448455ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000467097ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000467097ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000467097ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000471399ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000471399ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000471399ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000481450ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000481450ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000481450ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000490397ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000490397ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000490397ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000491367ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000491367ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000491367ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000495389ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000495389ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000495389ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000547221ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000547221ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000547221ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000549149ENST00000366707PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000549149ENST00000366709PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-5UTRENST00000549149ENST00000422127PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000376289ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000376289ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000420214ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000420214ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000433334ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000433334ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000441092ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000441092ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000448455ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000448455ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000467097ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000467097ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000471399ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000471399ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000481450ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000481450ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000490397ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000490397ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000491367ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000491367ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000495389ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000495389ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000547221ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000547221ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000549149ENST00000359599PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+
intron-intronENST00000549149ENST00000602685PSORS1C1chr6

31082668

+OBSCNchr1

228430884

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PSORS1C1-OBSCN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSORS1C1chr631082668+OBSCNchr1228430883+0.0004680660.999532
PSORS1C1chr631082668+OBSCNchr1228430883+0.0004680660.999532

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PSORS1C1-OBSCN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31082668/:228430884)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PSORS1C1-OBSCN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PSORS1C1-OBSCN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSORS1C1-OBSCN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSORS1C1-OBSCN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource