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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PSPC1-ACTR8 (FusionGDB2 ID:69778)

Fusion Gene Summary for PSPC1-ACTR8

Fusion gene summary

Fusion gene information	Fusion gene name: PSPC1-ACTR8
	Fusion gene ID: 69778
		Hgene	Tgene
	Gene symbol	PSPC1	ACTR8
	Gene ID	55269	93973
	Gene name	paraspeckle component 1	actin related protein 8
	Synonyms	PSP1	ARP8\|INO80N\|hArp8
	Cytomap	13q12.11	3p21.1
	Type of gene	protein-coding	protein-coding
	Description	paraspeckle component 1paraspeckle protein 1	actin-related protein 8ARP8 actin related protein 8 homologINO80 complex subunit N
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H981
	Ensembl transtripts involved in fusion gene	ENST00000338910, ENST00000497722,	ENST00000231909, ENST00000482349, ENST00000488802, ENST00000335754,
Fusion gene scores	* DoF score	13 X 13 X 5=845	4 X 4 X 3=48
	# samples	14	5
	** MAII score	log2(14/845*10)=-2.59352451422458 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: PSPC1 [Title/Abstract] AND ACTR8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PSPC1(20304379)-ACTR8(53914136), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PSPC1	GO:0002218	activation of innate immune response	28712728

Fusion gene breakpoints across PSPC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTR8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-E7-A85H-01A	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
ChimerDB4	BLCA	TCGA-E7-A85H	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-

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Fusion Gene ORF analysis for PSPC1-ACTR8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000338910	ENST00000231909	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
5CDS-intron	ENST00000338910	ENST00000231909	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
5CDS-intron	ENST00000338910	ENST00000482349	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
5CDS-intron	ENST00000338910	ENST00000482349	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
5CDS-intron	ENST00000338910	ENST00000488802	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
5CDS-intron	ENST00000338910	ENST00000488802	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
In-frame	ENST00000338910	ENST00000335754	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
In-frame	ENST00000338910	ENST00000335754	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
intron-3CDS	ENST00000497722	ENST00000335754	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
intron-3CDS	ENST00000497722	ENST00000335754	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
intron-intron	ENST00000497722	ENST00000231909	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
intron-intron	ENST00000497722	ENST00000231909	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
intron-intron	ENST00000497722	ENST00000482349	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
intron-intron	ENST00000497722	ENST00000482349	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-
intron-intron	ENST00000497722	ENST00000488802	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-
intron-intron	ENST00000497722	ENST00000488802	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338910	PSPC1	chr13	20304379	-	ENST00000335754	ACTR8	chr3	53914136	-	4723	1318	160	3069	969
ENST00000338910	PSPC1	chr13	20304378	-	ENST00000335754	ACTR8	chr3	53914136	-	4723	1318	160	3069	969

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338910	ENST00000335754	PSPC1	chr13	20304379	-	ACTR8	chr3	53914136	-	0.000813695	0.99918634
ENST00000338910	ENST00000335754	PSPC1	chr13	20304378	-	ACTR8	chr3	53914136	-	0.000813695	0.99918634

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Fusion Genomic Features for PSPC1-ACTR8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSPC1-ACTR8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:20304379/chr3:53914136)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTR8 Q9H981
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSPC1

chr13:20304378

chr3:53914136

ENST00000338910

283_377

386

524.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PSPC1

chr13:20304379

chr3:53914136

ENST00000338910

283_377

386

524.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PSPC1

chr13:20304378

chr3:53914136

ENST00000338910

156_237

386

524.0

Domain

RRM 2

Hgene

PSPC1

chr13:20304378

chr3:53914136

ENST00000338910

82_154

386

524.0

Domain

RRM 1

Hgene

PSPC1

chr13:20304379

chr3:53914136

ENST00000338910

156_237

386

524.0

Domain

RRM 2

Hgene

PSPC1

chr13:20304379

chr3:53914136

ENST00000338910

82_154

386

524.0

Domain

RRM 1

Hgene

PSPC1

chr13:20304378

chr3:53914136

ENST00000338910

125_358

386

524.0

Region

Note=Sufficient for paraspeckles localization

Hgene

PSPC1

chr13:20304379

chr3:53914136

ENST00000338910

125_358

386

524.0

Region

Note=Sufficient for paraspeckles localization

Tgene

ACTR8

chr13:20304378

chr3:53914136

ENST00000231909

283_286

330.0

Nucleotide binding

Note=ATP

Tgene

ACTR8

chr13:20304378

chr3:53914136

ENST00000335754

283_286

625.0

Nucleotide binding

Note=ATP

Tgene

ACTR8

chr13:20304378

chr3:53914136

ENST00000482349

283_286

514.0

Nucleotide binding

Note=ATP

Tgene

ACTR8

chr13:20304379

chr3:53914136

ENST00000231909

283_286

330.0

Nucleotide binding

Note=ATP

Tgene

ACTR8

chr13:20304379

chr3:53914136

ENST00000335754

283_286

625.0

Nucleotide binding

Note=ATP

Tgene

ACTR8

chr13:20304379

chr3:53914136

ENST00000482349

283_286

514.0

Nucleotide binding

Note=ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSPC1

chr13:20304378

chr3:53914136

ENST00000338910

394_516

386

524.0

Compositional bias

Note=Gly-rich

Hgene

PSPC1

chr13:20304379

chr3:53914136

ENST00000338910

394_516

386

524.0

Compositional bias

Note=Gly-rich

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Fusion Gene Sequence for PSPC1-ACTR8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>69778_69778_1_PSPC1-ACTR8_PSPC1_chr13_20304378_ENST00000338910_ACTR8_chr3_53914136_ENST00000335754_length(transcript)=4723nt_BP=1318nt
CGTGAGTTGGGGGAGGACGGGTTGCCGACTCGCCTACCTAGCGGTCTCTTGATTGTCGATATTTTGTTGGCATAGGTTTATGTAGAGACG
TATACATATATATAGACACACTGTCTATAAATCTAGGCCTGTATCCGGTGTCCGAGGCGAACTCAGTAAGATGATGTTAAGAGGAAACCT
GAAGCAAGTGCGCATTGAGAAAAACCCGGCCCGCCTTCGCGCCCTGGAGTCCGCGGTGGGCGAGAGCGAGCCGGCGGCCGCGGCAGCCAT
GGCGCTCGCTCTTGCCGGGGAGCCGGCACCGCCCGCGCCCGCGCCTCCAGAGGACCACCCGGACGAGGAGATGGGGTTCACTATCGACAT
CAAGAGTTTCCTCAAGCCGGGCGAGAAGACGTACACGCAGCGCTGCCGCCTCTTCGTGGGAAATCTGCCCACCGACATCACGGAGGAGGA
CTTCAAGAGGCTCTTCGAACGCTATGGCGAGCCCAGCGAAGTCTTCATCAACCGGGACCGTGGCTTCGGCTTCATCCGCTTGGAATCCAG
AACCCTGGCTGAAATTGCAAAAGCAGAGCTGGACGGCACCATTCTCAAGAGCAGACCTCTACGGATTCGCTTCGCTACACATGGAGCAGC
CTTGACTGTCAAGAACCTTTCTCCAGTTGTTTCCAATGAGCTGCTAGAGCAAGCATTTTCTCAGTTTGGTCCAGTAGAGAAAGCTGTTGT
GGTTGTGGATGATCGCGGTAGAGCTACAGGAAAAGGTTTTGTAGAGTTTGCAGCAAAACCTCCTGCACGAAAGGCTCTGGAAAGATGTGG
TGATGGGGCATTCTTGCTAACAACGACCCCTCGTCCAGTCATTGTGGAACCCATGGAGCAGTTTGATGATGAAGATGGCTTGCCAGAGAA
GCTGATGCAGAAAACTCAACAATATCATAAGGAAAGAGAACAACCACCACGTTTTGCTCAACCTGGGACATTTGAATTTGAGTATGCATC
TCGATGGAAGGCTCTTGATGAAATGGAAAAGCAGCAGCGTGAGCAGGTTGATAGAAACATCAGAGAAGCCAAAGAGAAACTGGAGGCAGA
AATGGAAGCAGCTAGGCATGAACACCAATTAATGCTAATGAGGCAAGATCTAATGAGGCGTCAAGAAGAACTCAGACGCTTGGAAGAACT
CAGAAACCAAGAGTTGCAAAAACGGAAGCAAATACAACTAAGACATGAAGAGGAGCATCGGCGGCGTGAGGAAGAAATGATCCGACACAG
AGAACAGGAGGAACTGAGGCGACAGCAAGAGGGCTTTAAGCCAAACTACATGGAAAATCAAATCCAGAGCAACTTCATCATTGTCATACA
TCCAGGTTCAACAACTTTAAGGATTGGTCGAGCCACAGACACTCTTCCTGCCAGCATTCCTCACGTCATTGCCCGAAGACACAAACAACA
AGGGCAGCCCCTATACAAGGACAGTTGGCTCCTAAGGGAGGGACTAAATAAACCAGAAAGTAATGAACAAAGACAAAATGGCCTTAAAAT
GGTGGATCAAGCAATATGGTCTAAAAAGATGTCCAATGGTACAAGACGCATTCCTGTGTCCCCTGAACAGGCACGCTCCTACAATAAGCA
GATGCGACCTGCAATTTTAGATCACTGTTCGGGAAATAAGTGGACAAACACATCTCATCACCCTGAGTATTTAGTAGGAGAAGAGGCCTT
GTATGTTAATCCACTGGACTGTTACAATATTCACTGGCCTATCAGAAGAGGTCAGTTAAATATTCACCCAGGCCCTGGGGGCTCTCTTAC
AGCTGTTCTGGCAGATATTGAAGTAATATGGTCTCATGCGATACAAAAATACTTGGAAATCCCACTGAAAGATTTAAAGTATTATAGATG
TATCTTGTTAATTCCTGATATCTATAATAAGCAGCATGTGAAAGAACTAGTGAATATGATACTAATGAAGATGGGTTTTTCAGGGATTGT
GGTCCATCAGGAGTCTGTGTGTGCCACCTATGGAAGTGGCTTAAGCAGCACGTGTATTGTAGACGTTGGGGACCAGAAGACAAGTGTATG
CTGTGTGGAGGATGGGGTGTCTCATCGGAATACTCGGCTTTGTCTGGCATACGGAGGATCTGATGTGTCAAGATGTTTTTACTGGCTAAT
GCAGCGAGCTGGGTTCCCTTACAGAGAATGCCAGTTAACAAATAAAATGGATTGTCTTCTTCTGCAACACCTTAAAGAAACTTTTTGTCA
TTTAGATCAGGACATCTCTGGGCTTCAGGACCATGAGTTTCAGATTCGACATCCTGATTCTCCTGCCCTGCTTTACCAGTTTCGATTAGG
AGATGAAAAACTGCAGGCTCCAATGGCTTTGTTTTACCCCGCAACTTTTGGAATCGTTGGACAGAAAATGACGACTTTGCAGCACAGATC
TCAGGGCGATCCTGAGGATCCTCACGATGAACATTACCTGCTGGCCACACAGAGCAAACAAGAACAGTCTGCAAAAGCTACTGCTGACCG
AAAGTCTGCATCCAAACCTATTGGATTTGAAGGGGATCTTCGTGGCCAGTCCTCTGATCTTCCAGAAAGACTCCATTCCCAGGAGGTAGA
TTTGGGGTCTGCACAGGGAGATGGCCTGATGGCCGGCAACGATTCCGAGGAGGCCCTCACTGCACTGATGTCCAGGAAGACTGCCATCTC
GCTGTTTGAAGGAAAAGCCCTGGGCCTGGATAAAGCCATCCTCCATAGCATAGACTGCTGTTCATCTGACGACACCAAAAAGAAGATGTA
CAGCTCCATCCTAGTGGTGGGAGGTGGTTTGATGTTTCATAAAGCTCAAGAATTTCTGCAGCACAGAATTCTCAACAAAATGCCACCATC
CTTCAGGCGAATTATTGAAAATGTGGATGTGATCACAAGGCCTAAGGACATGGACCCCCGGCTGATTGCATGGAAAGGAGGGGCAGTGTT
GGCTTGTTTGGATACAACACAGGAACTGTGGATTTATCAGCGAGAGTGGCAGCGCTTTGGTGTCCGCATGTTACGAGAGCGGGCTGCGTT
TGTGTGGTGAATGGGGAGGAAATGTCACTGCCGAAGACCAAAAACAAGCTTCTTGGTATAAAAGACTCTTACAGAATATGTGTATTGTAA
TTTATTGATCTGGATGCTTAAGTGTCATGGACAGTAAATGAATTTGAACTTTATGTTGAGGACATGACATTGGTTTGAAAATATAAACTG
CTTTTGAGCAGTTTAGTCAGGGCATTTGAGAATAAATAGGAACTTTCTCTTCAGTTGTAAACTCTCTTGCCCTCTCTCAGGGTCTCATAA
ACTCCCCAGTGATGTAAACGTTGCTATTGAAGGTTCTCATGTGGTGAAGCCCTTCATTTAAGTTGGCTTGAATCTCATCAGCAGGCAGCC
TCATGCAACCATGAGGGATAGTATGTGACGAGGGAGAACTGTCCACTCATGCCATTTTCTCTCTTGTCTAGTATTTCATTAGGATCTAAA
GTTGTCTGAGTTAAATGCACTTATGTGACTCATGTGTCCTCTTAGAATCCCAAATAGGGGGAAAAAGTTTTGGTGGTTTTTGTTTTTTTT
TTCATTTTCTGTTGGATTACAGAAAAAGAATGGGACCCATTCAGGTCTCGATTTCCAAAGGTAAAGATGGAAGGCTGGGCAGACTGGCTT
TTGTTACCTGACATGCCGTAGGGTGAGCTTAGAGGAAGAAAGAAAACAATTTTTATTTGGCCAAAACAGAACAAATGCTGAAAAGGAAAT
CTTGTTTTTTTCCTAAAGCCAAATAGAAATGATTTGGGTATAATTTAAGAGTCCTTGTGTTGTACAGATATGGTGACTGATGTAGTTATT
AATACTACCAACTTAGTCATCAAGCCTCAATTTTCCTTTACCTGAAGGATTAAGTGAAAGCTTTTGGAGTTCATGATGTTCAGTATGATC
AGTTAACCTTAACCTCTGAGCATCCTGAAGCAAAATCTAAATAATGCAGCTATTACCACTGGTGGTCCAGGCTCTGGTGAAGCCCTCTGA
GCCCAGGAGGAAGAGAAAGCATTGTCCAGAGGTAGGAACACAGTCTGGGAGCCCAGAGCTCTGGGAGGAGTGGGAAAATGCTGCTTCCTG
CTGCTTGCTTCTAGGCACCTGCTTCCGCCATCTCACTTACCATGGCTAGAGATGGGGGTGAGACTGGGGAAGGACAAAAGCAGGGAACAG
ATAAGTGATGGAAATCAGAAGGGAATATAGAAAGAACTCTGGATGTGGAGAAATGCCGGTACCTGAGCATTTTGTATCAATGGGAGTACC
CTCTGTAACTGCTCAGTAGGTTACAAATGAAGAGTCCACCAGTATTAGAAACAATTTAAACTTGCCAGTACCAACTGGGATGTGTGCCTT
CAATTTGAAAATTGTATGTTTTATTTTTTAAATTTGTTAACAGCATTAATTTATAGAGTATTGATGTCATTTATGTTTCTGAGGTGTTTC
AACACAATTTTGGATCAGCTGCCTGTTTGCAAAAACATAATATATTTCTGTTAAACAGTTCTTCACCTAACAGCATATTGCTCTTATAAC
TGGTAGAGCTGTTTCAAAGGAAGTTGGTTTCTGGTCCAAGTTTTGACCTAAACCATGTCCATCTTCTATTACCAGCACTTACAAGCACTG

>69778_69778_1_PSPC1-ACTR8_PSPC1_chr13_20304378_ENST00000338910_ACTR8_chr3_53914136_ENST00000335754_length(amino acids)=969AA_BP=386
MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLP
TDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFG
PVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGT
FEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRRE
EEMIRHREQEELRRQQEGFKPNYMENQIQSNFIIVIHPGSTTLRIGRATDTLPASIPHVIARRHKQQGQPLYKDSWLLREGLNKPESNEQ
RQNGLKMVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTSHHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHP
GPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVG
DQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPAL
LYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPER
LHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRI

--------------------------------------------------------------
>69778_69778_2_PSPC1-ACTR8_PSPC1_chr13_20304379_ENST00000338910_ACTR8_chr3_53914136_ENST00000335754_length(transcript)=4723nt_BP=1318nt
CGTGAGTTGGGGGAGGACGGGTTGCCGACTCGCCTACCTAGCGGTCTCTTGATTGTCGATATTTTGTTGGCATAGGTTTATGTAGAGACG
TATACATATATATAGACACACTGTCTATAAATCTAGGCCTGTATCCGGTGTCCGAGGCGAACTCAGTAAGATGATGTTAAGAGGAAACCT
GAAGCAAGTGCGCATTGAGAAAAACCCGGCCCGCCTTCGCGCCCTGGAGTCCGCGGTGGGCGAGAGCGAGCCGGCGGCCGCGGCAGCCAT
GGCGCTCGCTCTTGCCGGGGAGCCGGCACCGCCCGCGCCCGCGCCTCCAGAGGACCACCCGGACGAGGAGATGGGGTTCACTATCGACAT
CAAGAGTTTCCTCAAGCCGGGCGAGAAGACGTACACGCAGCGCTGCCGCCTCTTCGTGGGAAATCTGCCCACCGACATCACGGAGGAGGA
CTTCAAGAGGCTCTTCGAACGCTATGGCGAGCCCAGCGAAGTCTTCATCAACCGGGACCGTGGCTTCGGCTTCATCCGCTTGGAATCCAG
AACCCTGGCTGAAATTGCAAAAGCAGAGCTGGACGGCACCATTCTCAAGAGCAGACCTCTACGGATTCGCTTCGCTACACATGGAGCAGC
CTTGACTGTCAAGAACCTTTCTCCAGTTGTTTCCAATGAGCTGCTAGAGCAAGCATTTTCTCAGTTTGGTCCAGTAGAGAAAGCTGTTGT
GGTTGTGGATGATCGCGGTAGAGCTACAGGAAAAGGTTTTGTAGAGTTTGCAGCAAAACCTCCTGCACGAAAGGCTCTGGAAAGATGTGG
TGATGGGGCATTCTTGCTAACAACGACCCCTCGTCCAGTCATTGTGGAACCCATGGAGCAGTTTGATGATGAAGATGGCTTGCCAGAGAA
GCTGATGCAGAAAACTCAACAATATCATAAGGAAAGAGAACAACCACCACGTTTTGCTCAACCTGGGACATTTGAATTTGAGTATGCATC
TCGATGGAAGGCTCTTGATGAAATGGAAAAGCAGCAGCGTGAGCAGGTTGATAGAAACATCAGAGAAGCCAAAGAGAAACTGGAGGCAGA
AATGGAAGCAGCTAGGCATGAACACCAATTAATGCTAATGAGGCAAGATCTAATGAGGCGTCAAGAAGAACTCAGACGCTTGGAAGAACT
CAGAAACCAAGAGTTGCAAAAACGGAAGCAAATACAACTAAGACATGAAGAGGAGCATCGGCGGCGTGAGGAAGAAATGATCCGACACAG
AGAACAGGAGGAACTGAGGCGACAGCAAGAGGGCTTTAAGCCAAACTACATGGAAAATCAAATCCAGAGCAACTTCATCATTGTCATACA
TCCAGGTTCAACAACTTTAAGGATTGGTCGAGCCACAGACACTCTTCCTGCCAGCATTCCTCACGTCATTGCCCGAAGACACAAACAACA
AGGGCAGCCCCTATACAAGGACAGTTGGCTCCTAAGGGAGGGACTAAATAAACCAGAAAGTAATGAACAAAGACAAAATGGCCTTAAAAT
GGTGGATCAAGCAATATGGTCTAAAAAGATGTCCAATGGTACAAGACGCATTCCTGTGTCCCCTGAACAGGCACGCTCCTACAATAAGCA
GATGCGACCTGCAATTTTAGATCACTGTTCGGGAAATAAGTGGACAAACACATCTCATCACCCTGAGTATTTAGTAGGAGAAGAGGCCTT
GTATGTTAATCCACTGGACTGTTACAATATTCACTGGCCTATCAGAAGAGGTCAGTTAAATATTCACCCAGGCCCTGGGGGCTCTCTTAC
AGCTGTTCTGGCAGATATTGAAGTAATATGGTCTCATGCGATACAAAAATACTTGGAAATCCCACTGAAAGATTTAAAGTATTATAGATG
TATCTTGTTAATTCCTGATATCTATAATAAGCAGCATGTGAAAGAACTAGTGAATATGATACTAATGAAGATGGGTTTTTCAGGGATTGT
GGTCCATCAGGAGTCTGTGTGTGCCACCTATGGAAGTGGCTTAAGCAGCACGTGTATTGTAGACGTTGGGGACCAGAAGACAAGTGTATG
CTGTGTGGAGGATGGGGTGTCTCATCGGAATACTCGGCTTTGTCTGGCATACGGAGGATCTGATGTGTCAAGATGTTTTTACTGGCTAAT
GCAGCGAGCTGGGTTCCCTTACAGAGAATGCCAGTTAACAAATAAAATGGATTGTCTTCTTCTGCAACACCTTAAAGAAACTTTTTGTCA
TTTAGATCAGGACATCTCTGGGCTTCAGGACCATGAGTTTCAGATTCGACATCCTGATTCTCCTGCCCTGCTTTACCAGTTTCGATTAGG
AGATGAAAAACTGCAGGCTCCAATGGCTTTGTTTTACCCCGCAACTTTTGGAATCGTTGGACAGAAAATGACGACTTTGCAGCACAGATC
TCAGGGCGATCCTGAGGATCCTCACGATGAACATTACCTGCTGGCCACACAGAGCAAACAAGAACAGTCTGCAAAAGCTACTGCTGACCG
AAAGTCTGCATCCAAACCTATTGGATTTGAAGGGGATCTTCGTGGCCAGTCCTCTGATCTTCCAGAAAGACTCCATTCCCAGGAGGTAGA
TTTGGGGTCTGCACAGGGAGATGGCCTGATGGCCGGCAACGATTCCGAGGAGGCCCTCACTGCACTGATGTCCAGGAAGACTGCCATCTC
GCTGTTTGAAGGAAAAGCCCTGGGCCTGGATAAAGCCATCCTCCATAGCATAGACTGCTGTTCATCTGACGACACCAAAAAGAAGATGTA
CAGCTCCATCCTAGTGGTGGGAGGTGGTTTGATGTTTCATAAAGCTCAAGAATTTCTGCAGCACAGAATTCTCAACAAAATGCCACCATC
CTTCAGGCGAATTATTGAAAATGTGGATGTGATCACAAGGCCTAAGGACATGGACCCCCGGCTGATTGCATGGAAAGGAGGGGCAGTGTT
GGCTTGTTTGGATACAACACAGGAACTGTGGATTTATCAGCGAGAGTGGCAGCGCTTTGGTGTCCGCATGTTACGAGAGCGGGCTGCGTT
TGTGTGGTGAATGGGGAGGAAATGTCACTGCCGAAGACCAAAAACAAGCTTCTTGGTATAAAAGACTCTTACAGAATATGTGTATTGTAA
TTTATTGATCTGGATGCTTAAGTGTCATGGACAGTAAATGAATTTGAACTTTATGTTGAGGACATGACATTGGTTTGAAAATATAAACTG
CTTTTGAGCAGTTTAGTCAGGGCATTTGAGAATAAATAGGAACTTTCTCTTCAGTTGTAAACTCTCTTGCCCTCTCTCAGGGTCTCATAA
ACTCCCCAGTGATGTAAACGTTGCTATTGAAGGTTCTCATGTGGTGAAGCCCTTCATTTAAGTTGGCTTGAATCTCATCAGCAGGCAGCC
TCATGCAACCATGAGGGATAGTATGTGACGAGGGAGAACTGTCCACTCATGCCATTTTCTCTCTTGTCTAGTATTTCATTAGGATCTAAA
GTTGTCTGAGTTAAATGCACTTATGTGACTCATGTGTCCTCTTAGAATCCCAAATAGGGGGAAAAAGTTTTGGTGGTTTTTGTTTTTTTT
TTCATTTTCTGTTGGATTACAGAAAAAGAATGGGACCCATTCAGGTCTCGATTTCCAAAGGTAAAGATGGAAGGCTGGGCAGACTGGCTT
TTGTTACCTGACATGCCGTAGGGTGAGCTTAGAGGAAGAAAGAAAACAATTTTTATTTGGCCAAAACAGAACAAATGCTGAAAAGGAAAT
CTTGTTTTTTTCCTAAAGCCAAATAGAAATGATTTGGGTATAATTTAAGAGTCCTTGTGTTGTACAGATATGGTGACTGATGTAGTTATT
AATACTACCAACTTAGTCATCAAGCCTCAATTTTCCTTTACCTGAAGGATTAAGTGAAAGCTTTTGGAGTTCATGATGTTCAGTATGATC
AGTTAACCTTAACCTCTGAGCATCCTGAAGCAAAATCTAAATAATGCAGCTATTACCACTGGTGGTCCAGGCTCTGGTGAAGCCCTCTGA
GCCCAGGAGGAAGAGAAAGCATTGTCCAGAGGTAGGAACACAGTCTGGGAGCCCAGAGCTCTGGGAGGAGTGGGAAAATGCTGCTTCCTG
CTGCTTGCTTCTAGGCACCTGCTTCCGCCATCTCACTTACCATGGCTAGAGATGGGGGTGAGACTGGGGAAGGACAAAAGCAGGGAACAG
ATAAGTGATGGAAATCAGAAGGGAATATAGAAAGAACTCTGGATGTGGAGAAATGCCGGTACCTGAGCATTTTGTATCAATGGGAGTACC
CTCTGTAACTGCTCAGTAGGTTACAAATGAAGAGTCCACCAGTATTAGAAACAATTTAAACTTGCCAGTACCAACTGGGATGTGTGCCTT
CAATTTGAAAATTGTATGTTTTATTTTTTAAATTTGTTAACAGCATTAATTTATAGAGTATTGATGTCATTTATGTTTCTGAGGTGTTTC
AACACAATTTTGGATCAGCTGCCTGTTTGCAAAAACATAATATATTTCTGTTAAACAGTTCTTCACCTAACAGCATATTGCTCTTATAAC
TGGTAGAGCTGTTTCAAAGGAAGTTGGTTTCTGGTCCAAGTTTTGACCTAAACCATGTCCATCTTCTATTACCAGCACTTACAAGCACTG

>69778_69778_2_PSPC1-ACTR8_PSPC1_chr13_20304379_ENST00000338910_ACTR8_chr3_53914136_ENST00000335754_length(amino acids)=969AA_BP=386
MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLP
TDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFG
PVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGT
FEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRRE
EEMIRHREQEELRRQQEGFKPNYMENQIQSNFIIVIHPGSTTLRIGRATDTLPASIPHVIARRHKQQGQPLYKDSWLLREGLNKPESNEQ
RQNGLKMVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTSHHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHP
GPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVG
DQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPAL
LYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPER
LHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRI

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Fusion Gene PPI Analysis for PSPC1-ACTR8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PSPC1-ACTR8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PSPC1-ACTR8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source