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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTBP1-UBE3C (FusionGDB2 ID:69838)

Fusion Gene Summary for PTBP1-UBE3C

check button Fusion gene summary
Fusion gene informationFusion gene name: PTBP1-UBE3C
Fusion gene ID: 69838
HgeneTgene
Gene symbol

PTBP1

UBE3C

Gene ID

5725

9690

Gene namepolypyrimidine tract binding protein 1ubiquitin protein ligase E3C
SynonymsHNRNP-I|HNRNPI|HNRPI|PTB|PTB-1|PTB-T|PTB2|PTB3|PTB4|pPTBHECTH2
Cytomap

19p13.3

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionpolypyrimidine tract-binding protein 157 kDa RNA-binding protein PPTB-1RNA-binding proteinheterogeneous nuclear ribonucleoprotein Iheterogeneous nuclear ribonucleoprotein polypeptide IhnRNP Ipolypyrimidine tract binding protein (heterogeneous nucleaubiquitin-protein ligase E3CHECT-type ubiquitin transferase E3Cubiquitin-protein isopeptide ligase (E3)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000349038, ENST00000356948, 
ENST00000394601, ENST00000350092, 
ENST00000389103, ENST00000348165, 
Fusion gene scores* DoF score16 X 17 X 9=244811 X 13 X 7=1001
# samples 1713
** MAII scorelog2(17/2448*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTBP1 [Title/Abstract] AND UBE3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTBP1(804438)-UBE3C(157009561), # samples:2
Anticipated loss of major functional domain due to fusion event.PTBP1-UBE3C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTBP1-UBE3C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTBP1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

16260624|21518792

HgenePTBP1

GO:0033119

negative regulation of RNA splicing

18335065

HgenePTBP1

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664

HgenePTBP1

GO:0051148

negative regulation of muscle cell differentiation

21518792

TgeneUBE3C

GO:0000209

protein polyubiquitination

11278995


check buttonFusion gene breakpoints across PTBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBE3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A6E1-01APTBP1chr19

803636

-UBE3Cchr7

157009561

+
ChimerDB4PRADTCGA-KK-A6E1-01APTBP1chr19

804438

+UBE3Cchr7

157009561

+
ChimerDB4PRADTCGA-KK-A6E1PTBP1chr19

804438

+UBE3Cchr7

157009561

+


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Fusion Gene ORF analysis for PTBP1-UBE3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000349038ENST00000389103PTBP1chr19

803636

-UBE3Cchr7

157009561

+
5CDS-intronENST00000349038ENST00000389103PTBP1chr19

804438

+UBE3Cchr7

157009561

+
5CDS-intronENST00000356948ENST00000389103PTBP1chr19

803636

-UBE3Cchr7

157009561

+
5CDS-intronENST00000356948ENST00000389103PTBP1chr19

804438

+UBE3Cchr7

157009561

+
5CDS-intronENST00000394601ENST00000389103PTBP1chr19

803636

-UBE3Cchr7

157009561

+
5CDS-intronENST00000394601ENST00000389103PTBP1chr19

804438

+UBE3Cchr7

157009561

+
Frame-shiftENST00000349038ENST00000348165PTBP1chr19

803636

-UBE3Cchr7

157009561

+
Frame-shiftENST00000356948ENST00000348165PTBP1chr19

803636

-UBE3Cchr7

157009561

+
Frame-shiftENST00000394601ENST00000348165PTBP1chr19

803636

-UBE3Cchr7

157009561

+
In-frameENST00000349038ENST00000348165PTBP1chr19

804438

+UBE3Cchr7

157009561

+
In-frameENST00000356948ENST00000348165PTBP1chr19

804438

+UBE3Cchr7

157009561

+
In-frameENST00000394601ENST00000348165PTBP1chr19

804438

+UBE3Cchr7

157009561

+
intron-3CDSENST00000350092ENST00000348165PTBP1chr19

803636

-UBE3Cchr7

157009561

+
intron-3CDSENST00000350092ENST00000348165PTBP1chr19

804438

+UBE3Cchr7

157009561

+
intron-intronENST00000350092ENST00000389103PTBP1chr19

803636

-UBE3Cchr7

157009561

+
intron-intronENST00000350092ENST00000389103PTBP1chr19

804438

+UBE3Cchr7

157009561

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356948PTBP1chr19804438+ENST00000348165UBE3Cchr7157009561+39188583602300646
ENST00000349038PTBP1chr19804438+ENST00000348165UBE3Cchr7157009561+3568508101950646
ENST00000394601PTBP1chr19804438+ENST00000348165UBE3Cchr7157009561+3541481371923628

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356948ENST00000348165PTBP1chr19804438+UBE3Cchr7157009561+0.0007221350.9992779
ENST00000349038ENST00000348165PTBP1chr19804438+UBE3Cchr7157009561+0.0006799390.99932003
ENST00000394601ENST00000348165PTBP1chr19804438+UBE3Cchr7157009561+0.0006761910.99932384

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Fusion Genomic Features for PTBP1-UBE3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTBP1chr19804438+UBE3Cchr7157009560+0.0253132940.9746867
PTBP1chr19804438+UBE3Cchr7157009560+0.0253132940.9746867
PTBP1chr19804438+UBE3Cchr7157009560+0.0253132940.9746867
PTBP1chr19804438+UBE3Cchr7157009560+0.0253132940.9746867

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTBP1-UBE3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:804438/chr7:157009561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTBP1chr19:804438chr7:157009561ENST00000349038+51459_143145532.0DomainRRM 1
HgenePTBP1chr19:804438chr7:157009561ENST00000356948+51559_143145558.0DomainRRM 1
HgenePTBP1chr19:804438chr7:157009561ENST00000394601+51559_143145551.0DomainRRM 1
TgeneUBE3Cchr19:804438chr7:157009561ENST000003481651223744_10836031084.0DomainHECT
TgeneUBE3Cchr19:804438chr7:157009561ENST000003891030945_740405.0DomainIQ
TgeneUBE3Cchr19:804438chr7:157009561ENST0000038910309744_10830405.0DomainHECT
TgeneUBE3Cchr19:804438chr7:157009561ENST00000389103091_600405.0RegionNote=Cis-determinant of acceptor ubiquitin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTBP1chr19:804438chr7:157009561ENST00000349038+514316_323145532.0Compositional biasNote=Poly-Ala
HgenePTBP1chr19:804438chr7:157009561ENST00000356948+515316_323145558.0Compositional biasNote=Poly-Ala
HgenePTBP1chr19:804438chr7:157009561ENST00000394601+515316_323145551.0Compositional biasNote=Poly-Ala
HgenePTBP1chr19:804438chr7:157009561ENST00000349038+514184_260145532.0DomainRRM 2
HgenePTBP1chr19:804438chr7:157009561ENST00000349038+514337_411145532.0DomainRRM 3
HgenePTBP1chr19:804438chr7:157009561ENST00000349038+514454_529145532.0DomainRRM 4
HgenePTBP1chr19:804438chr7:157009561ENST00000356948+515184_260145558.0DomainRRM 2
HgenePTBP1chr19:804438chr7:157009561ENST00000356948+515337_411145558.0DomainRRM 3
HgenePTBP1chr19:804438chr7:157009561ENST00000356948+515454_529145558.0DomainRRM 4
HgenePTBP1chr19:804438chr7:157009561ENST00000394601+515184_260145551.0DomainRRM 2
HgenePTBP1chr19:804438chr7:157009561ENST00000394601+515337_411145551.0DomainRRM 3
HgenePTBP1chr19:804438chr7:157009561ENST00000394601+515454_529145551.0DomainRRM 4
TgeneUBE3Cchr19:804438chr7:157009561ENST00000348165122345_746031084.0DomainIQ
TgeneUBE3Cchr19:804438chr7:157009561ENST0000034816512231_606031084.0RegionNote=Cis-determinant of acceptor ubiquitin-binding


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Fusion Gene Sequence for PTBP1-UBE3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69838_69838_1_PTBP1-UBE3C_PTBP1_chr19_804438_ENST00000349038_UBE3C_chr7_157009561_ENST00000348165_length(transcript)=3568nt_BP=508nt
CTCGGAGCCGTTGGGTCGGTTCCTGCTATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCC
AGATATAGCCGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGC
TTCTGCAGCAAACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCT
CCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCA
GGCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCAT
CTACATCCAGTTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTAGTGAAAATGTTGAAGTC
CAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGT
GCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCC
GCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAG
GTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGA
AGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGA
AGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGAC
TACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAAT
GCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGT
GGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGG
GCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGC
CAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGC
CAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGA
GGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCAC
TGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTG
TATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGAC
ACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGA
GAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTC
ATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACT
TAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTA
ACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGC
GGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTG
AAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGC
CATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGT
GGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACT
GCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGC
ATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATT
TGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAG
AGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCA
AAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTT
TACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTT
AAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATA
CAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTA
TTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATT

>69838_69838_1_PTBP1-UBE3C_PTBP1_chr19_804438_ENST00000349038_UBE3C_chr7_157009561_ENST00000348165_length(amino acids)=646AA_BP=166
MGRFLLFRRLHSVPRGSALCAMDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPID
VTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQAVITNLVKMLKSRDT
RRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIY
ADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNE
GLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNF
TVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLK
SFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLR

--------------------------------------------------------------
>69838_69838_2_PTBP1-UBE3C_PTBP1_chr19_804438_ENST00000356948_UBE3C_chr7_157009561_ENST00000348165_length(transcript)=3918nt_BP=858nt
GGGCAAAGCACGCTTCCCGCCGCCTGACTCGCCACGTACCCACTCTCAAGATGGCGTCTCCCGCAAAGCCACGCGCCAGCTGACTGGCTC
AGACGCCGTCACGTGATCCCATTTTCTCCCCCTCCCCCGACTACACAAGCCGTTTCCGCCTTCGGCCTTGAGGAATAACCGCCTCCCCCA
ATAGGCGCCTGCGATTTCTCTGGGTCCCGCCCCCGGGCGGCCTTCTGGCCAGTGGGAGGTGCTGGCGGGGGCCCGCGGGGCTCTCCCCGC
CCCCTGGCTGCAGCGGGAGCCAATGGGCAGCGCGCGCGGGGGACGTGTGCGGGCGTCTCCGCCATTTTGTGAGTCTATAACTCGGAGCCG
TTGGGTCGGTTCCTGCTATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCCAGATATAGCC
GTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGCTTCTGCAGCA
AACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCTCCCCATCGAC
GTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCAGGCCTTCATC
GAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCATCTACATCCAG
TTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACG
AGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCC
AGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTG
TCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTAT
GCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTAT
GACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATT
GATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAA
GGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAG
GCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCAC
CACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTC
ACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATT
GCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTC
AGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAA
TCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAA
AAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAAC
GGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGA
AGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGC
TTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCAT
TCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACA
CGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATG
AAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATA
CAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTT
TTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCA
AATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCA
TTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTG
TCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCC
CGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGAC
TCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCG
GTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGC
TGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACT
GGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGA
ACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAA
ATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTT
GGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTG

>69838_69838_2_PTBP1-UBE3C_PTBP1_chr19_804438_ENST00000356948_UBE3C_chr7_157009561_ENST00000348165_length(amino acids)=646AA_BP=166
MGRFLLFRRLHSVPRGSALCAMDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPID
VTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQAVITNLVKMLKSRDT
RRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIY
ADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNE
GLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNF
TVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLK
SFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLR

--------------------------------------------------------------
>69838_69838_3_PTBP1-UBE3C_PTBP1_chr19_804438_ENST00000394601_UBE3C_chr7_157009561_ENST00000348165_length(transcript)=3541nt_BP=481nt
ATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCCAGATATAGCCGTTGGTACAAAGCGGGG
ATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGCTTCTGCAGCAAACGGAAATGACAGCAA
GAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCTCCCCATCGACGTCACGGAGGGGGAAGT
CATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCAGGCCTTCATCGAGATGAACACGGAGGA
GGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGA
GCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCC
TCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTT
CCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCT
TGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGT
TCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGA
AAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTT
CAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAA
CCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACAT
GCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGA
CCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGA
CCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGT
GGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCG
AATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTC
AGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAA
GTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGA
GCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGC
GATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCG
CCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTT
TTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGG
CTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTG
GTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGA
GACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTT
CCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCT
TGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCT
ATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAG
TTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCG
GTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACC
CTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGG
CACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGAC
CCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTG
TCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAA
TGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCT
TTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGA
GACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAATGGCTAA

>69838_69838_3_PTBP1-UBE3C_PTBP1_chr19_804438_ENST00000394601_UBE3C_chr7_157009561_ENST00000348165_length(amino acids)=628AA_BP=148
MCAMDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTN
LLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQAVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIK
ADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINV
TIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFA
RHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFG
GKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTBP1-UBE3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTBP1-UBE3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTBP1-UBE3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource