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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTBP2-TMEM56 (FusionGDB2 ID:69846)

Fusion Gene Summary for PTBP2-TMEM56

check button Fusion gene summary
Fusion gene informationFusion gene name: PTBP2-TMEM56
Fusion gene ID: 69846
HgeneTgene
Gene symbol

PTBP2

TMEM56

Gene ID

58155

148534

Gene namepolypyrimidine tract binding protein 2TLC domain containing 4
SynonymsPTBLP|brPTB|nPTBTMEM56
Cytomap

1p21.3

1p21.3

Type of geneprotein-codingprotein-coding
Descriptionpolypyrimidine tract-binding protein 2PTB-like proteinneural polypyrimidine tract binding proteinneurally-enriched homolog of PTBTLC domain-containing protein 4transmembrane protein 56
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000482253, ENST00000370197, 
ENST00000370198, ENST00000426398, 
ENST00000609116, ENST00000394184, 
ENST00000541987, 		ENST00000370203, 
ENST00000463375, 
Fusion gene scores* DoF score8 X 6 X 4=1924 X 4 X 3=48
# samples 94
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTBP2 [Title/Abstract] AND TMEM56 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTBP2(97189150)-TMEM56(95657106), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTBP2

GO:0033119

negative regulation of RNA splicing

18335065


check buttonFusion gene breakpoints across PTBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM56 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315453PTBP2chr1

97189150

+TMEM56chr1

95657106

+


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Fusion Gene ORF analysis for PTBP2-TMEM56

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482253ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+
3UTR-intronENST00000482253ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5CDS-intronENST00000370197ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5CDS-intronENST00000370198ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5CDS-intronENST00000426398ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5CDS-intronENST00000609116ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5UTR-3CDSENST00000394184ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5UTR-3CDSENST00000541987ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5UTR-intronENST00000394184ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
5UTR-intronENST00000541987ENST00000463375PTBP2chr1

97189150

+TMEM56chr1

95657106

+
In-frameENST00000370197ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+
In-frameENST00000370198ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+
In-frameENST00000426398ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+
In-frameENST00000609116ENST00000370203PTBP2chr1

97189150

+TMEM56chr1

95657106

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000609116PTBP2chr197189150+ENST00000370203TMEM56chr195657106+6179121137439100
ENST00000370197PTBP2chr197189150+ENST00000370203TMEM56chr195657106+615294110412100
ENST00000370198PTBP2chr197189150+ENST00000370203TMEM56chr195657106+615294110412100
ENST00000426398PTBP2chr197189150+ENST00000370203TMEM56chr195657106+61408298400100

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000609116ENST00000370203PTBP2chr197189150+TMEM56chr195657106+0.488999520.51100045
ENST00000370197ENST00000370203PTBP2chr197189150+TMEM56chr195657106+0.494162560.50583744
ENST00000370198ENST00000370203PTBP2chr197189150+TMEM56chr195657106+0.494162560.50583744
ENST00000426398ENST00000370203PTBP2chr197189150+TMEM56chr195657106+0.49174310.5082569

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Fusion Genomic Features for PTBP2-TMEM56


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTBP2chr197189150+TMEM56chr195657105+4.72E-050.9999528
PTBP2chr197189150+TMEM56chr195657105+4.72E-050.9999528

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTBP2-TMEM56


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:97189150/chr1:95657106)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM56chr1:97189150chr1:95657106ENST0000037020357173_193157264.0TransmembraneHelical
TgeneTMEM56chr1:97189150chr1:95657106ENST0000037020357211_231157264.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTBP2chr1:97189150chr1:95657106ENST00000370197+214315_32413538.0Compositional biasNote=Poly-Ala
HgenePTBP2chr1:97189150chr1:95657106ENST00000370198+214315_32413537.0Compositional biasNote=Poly-Ala
HgenePTBP2chr1:97189150chr1:95657106ENST00000426398+214315_32413532.0Compositional biasNote=Poly-Ala
HgenePTBP2chr1:97189150chr1:95657106ENST00000370197+214181_25713538.0DomainRRM 2
HgenePTBP2chr1:97189150chr1:95657106ENST00000370197+214338_41213538.0DomainRRM 3
HgenePTBP2chr1:97189150chr1:95657106ENST00000370197+214455_52913538.0DomainRRM 4
HgenePTBP2chr1:97189150chr1:95657106ENST00000370197+21459_13313538.0DomainRRM 1
HgenePTBP2chr1:97189150chr1:95657106ENST00000370198+214181_25713537.0DomainRRM 2
HgenePTBP2chr1:97189150chr1:95657106ENST00000370198+214338_41213537.0DomainRRM 3
HgenePTBP2chr1:97189150chr1:95657106ENST00000370198+214455_52913537.0DomainRRM 4
HgenePTBP2chr1:97189150chr1:95657106ENST00000370198+21459_13313537.0DomainRRM 1
HgenePTBP2chr1:97189150chr1:95657106ENST00000426398+214181_25713532.0DomainRRM 2
HgenePTBP2chr1:97189150chr1:95657106ENST00000426398+214338_41213532.0DomainRRM 3
HgenePTBP2chr1:97189150chr1:95657106ENST00000426398+214455_52913532.0DomainRRM 4
HgenePTBP2chr1:97189150chr1:95657106ENST00000426398+21459_13313532.0DomainRRM 1
TgeneTMEM56chr1:97189150chr1:95657106ENST000003702035744_246157264.0DomainTLC
TgeneTMEM56chr1:97189150chr1:95657106ENST0000037020357124_144157264.0TransmembraneHelical
TgeneTMEM56chr1:97189150chr1:95657106ENST000003702035753_73157264.0TransmembraneHelical
TgeneTMEM56chr1:97189150chr1:95657106ENST00000370203577_27157264.0TransmembraneHelical
TgeneTMEM56chr1:97189150chr1:95657106ENST000003702035790_110157264.0TransmembraneHelical


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Fusion Gene Sequence for PTBP2-TMEM56


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69846_69846_1_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000370197_TMEM56_chr1_95657106_ENST00000370203_length(transcript)=6152nt_BP=94nt
GGCTCGCTGGCTGCGTGGCTCGGTTCTTGTGAGCGAAGCTTTGTCCGGTTCGGCAATGGACGGAATCGTCACTGAGGTTGCAGTTGGCGT
GAAGGTGGTTCTTTGAAGCTCTGAAGTATCCCAAGTTTTCTAAAGCTATCGTTATCAATGGAATACTCATGACAGTAGTATTCTTCATCG
TGCGGATTGCCTCAATGCTTCCTCATTATGGCTTCATGTATTCCGTGTATGGAACAGAACCCTACATAAGGCTTGGAGTTTTAATCCAGT
TATCCTGGGTCATTAGTTGTGTTGTTTTGGATGTGATGAATGTCATGTGGATGATCAAAATTTCAAAAGGTTGCATCAAAGTCATCTCTC
ACATCAGACAAGAGAAAGCCAAAAATAGTCTTCAGAATGGAAAACTTGATTAAAAGAGTGCTACCGATAAGCAAACTTCATTACTACCCA
GCATATCTGCTGATAGGATGAATTCTTGGCATGTTCTTGTGTACCTTTCTTAATTATAATTGTTATTCAGGATTTCAGTGTCATTTTTTT
TAAACCTTAGAAAAGAGAAGGCCGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTCGATCACTGAGGTC
AGGAGTTCGAGACTAGCTTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAAAAAGTAGCTGGGCGTGGTGGTTGGCGCCT
GTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGAGAGACGGAGGTTGCAGTGAGCTGATATTGTGCCACTGCAC
TCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGAGAGAAACTAAAATTAAAATTTAGTTTTCATCCCAAGATGTC
TTTTCTGCCTTTCTTTTGCCTTATTTACAAGCATGGATAAAAATCTTAAAGGTTTAAATAAAAATGATCAATATAATGGTGAATCTTTTG
AGAAATCTCTTAACTGCATTGGTATTTTTTCTCTGTGAAAGATGACTATGATAATCTGGTACAAATGGTTTTATGTCACCAATTTTGCTG
CAAGAATGGGAACTGCTTTTAAATCTGTAAATAGCTCTTAACATTTGTTGTATGCACTCTTTTCTTACTATGGCTGTCAACACTTGTGTA
GGGTTTAATTTCTAAATTGTTGGCATGTTCTTTTTCTCAGGCTATTCAGAAGTAACAACATTTTTCATTTCAGACATGCAATCACCTATT
AATGATGAAATATTTTACCACTTTGGGAATATTTAATTAGTTTAGTCATGGAGAATACTTCCCACATTTTAAGATTTTTTCAAATATCAC
TGTCATTTCTATTTTAGCATTTTATCAAATTATTGCTTTTTTATTTTATAATAAGGCTTAAGACAGATTATAGACCTCCTTAAGAGATGA
GTTTCTTCTTCTAAAAATGCATGTTGATAGAGGACTATTTAGGCTAATCGGAGGAATCATTAAGAAAGAAAGTTTTAACACTGTTTATCC
CTATCTGCTTTCCTTGCACTTTTTCTGTGAAAAATATTTTCTGTTTGCAAAATCTTCCCTGAGTTCTGAACCCAGCACCATCAGTACCAA
AGTCTTATGCAATATGTATTTATTATGCTCCTGAAATAGGCCTCTTCTTGATGAGACCCAAACTATTACAAAAATATCAGTATTCATATT
TTACTCACAATTCATACCCGTGCTTACTTAGTTGGCATTTTAGTGCTTTGAATTTCTATCTTAAAGCACAGAAAAAAAAAGGTAATTTAA
TCCAAGTATTCTATCATCAAAATTATTGTCTGATTATATGAAGATAAATGACTGGCGACTCTGGTTGTGTGTGTATGTGTTTTGCTTTTA
CTTTAATTCTTGCAATCCAAATATAGAATTATATATTTATCTATTATTGCCTTTATTCTTTAAGCACTTGAGTTTAATGATTATTCTTAC
CTGAGAAAGGAAGAAATTTAATTCTACCAGTGATGAATACTTGAAATTAATTGAACTCATACCAAAAGATGTAATCCAGTTTCTCAGTTT
GAAGGAGAACGTTTGACTCACTTTCATTGTTCATGCTAGCTGAATATAATCAAGACTTTTGATTTGATTTGCTTTTATTATTCAATGCAG
ATAGAGCCTGATAAGTTTTAGAACATTTAAAGAAGATTGAAATCTCAGTCAGTAACTAAATGATAAAATGAGATTGATTGGCTTATACTA
GGTACATTTATTTTTGAAAGAATTAATGTAAAATAATAGTTATTTTTAAAGCAGCTAATATTACACTGATAATTTGTTGCTAAATTTAGT
GCTGTCCACATCATAGGTGCTTAAATATGTACTGGTTAACTAGAGGGGGGTAGGAAAGCAAGCGGTTTTATCTTGTTCTTACCTTTTTGC
AGGAAAAGTGGCTTTAAAAAAATTTATATAATAAAACTATTTTGGAAATTCATTCTTTTAGAAAGAGACCTTGAGATAAATATTTTTTGA
CTCTGGATATTTCTATAGTTCTGAACACAGATTTTAAACCCACTATCAAAATGAAAACAATATAAAGCTATATTAGTGAGTCTCCATGTA
GCAGTTTGTTTTTATAGTTACTGTTTCATGCTTAAAACTTCATTCTTACTTTCATTAATGTTACCCTTCACTGGTATAGCCACTCACTAA
ATAAGTATATTTAAAACATCAAAATTTTGAACTAAAGTTTGTGATTCTCTTATTCAGCAATCCTTATCTTATGCTGGCTGCATGAGTTAA
TTCAACATCCAGATTAAATATCCTGAAGTAGGTTCTATATATTTCCTCATACAACAGACATGGAATGGAAATGCCACTAGAAACTGCCCT
GCTACTTTTAAGTCTGACCTTTGCAGGAGGTACACTTTGCTGTTCTATGATTGTATTCACCTACCTAAAATACAAATGAAGACAGAACAT
ATCATTTACTGCACGATGAATTTTTCATTTATTAAATGAAAAACGTTTGCTAGACATTTTAAATATTAAGTATTTTGACTACACGGATTA
ATTTAAATGATTCTATCAGGCATTCTGATATTTAACAACTCTATTAAAATATTTATAGAAAAATAAAAGCAAATTGATATAAATTTTTGA
GCAATTCTATTTTTGTAGAAAAAAGATAACCTGTAATTATAAAGATGTTTTTTGAATGTGTAGTATCCTAGAAAATAAAAGTTCTTGTGA
AACTTAAAAAATGAATGAAAACCAACTAATAGCATGCAAGATCATAGATCCTGCATTAAATTTTTATTTGTGAAAATTTGAAAATTATGA
GCTATAACTTATAAAGTTTGCCTTCTTATGTCTAAAATCTTTTAAAGGATTATTTGCATTTATGTAAAACTGGAAATGAAGTTATATATG
AGTGCAAAGAAATTGACTTCTGCTCAAATATGTGTTGATACCCTACAGTAAATTGAATTAAATTTTTATCCCAACTGTTTGATTTTATTA
TTTCATGGACTAGCCTTACGTTAAGTGAAATACTATTTATGTTGTTACCACCCCTAAGAGTGACTCTGATATATTATGGATGACCCAGGA
CGGTCTTAAAGGTCTAGTTTTAAAAACTGCCTAGTTTGTAAGTATTTGAATCCAGTTCTTTTCTAAATTTTAATAATTTGACTCAAAATT
TTTGCTACAGGGTCAACTTTTAAATTGTATATTTCCTCTGAGGCACACTGGGCATTTGGAGAATGGTTCTTCACTGGTGTAGAGAGCCAG
GTTTACTGTTGGTTGCACCATCTGTTATCAGGCATGCAGAAACATTTTTCTTCTGGAGAAACAGAGGGGAAGGTGTTGTTACAGTGTACA
TGTTTCCTCTGTGTCGTTTTTAAGGGAAATAAACATGTTCCAAAAGATGCTGTTAAAATAAATATTTGAACACGTTTTCTGTTTCTAGGT
TGCTCTTAATTCCAAACATTTAAATAAATGTGCATTTGAATAGCTTTAGGTGGTTTAGTCTATTAGCTGAAATGGAAAAGTTCATGTATT
GACATCATCAATAATACTTCATAAAGGTTTATGTATTTTTATGTGTTTGGATTCCATAAGAAGTTGAACTTAGATAATTTTATCAAGAGT
AGCACAGTGTTTCTCAGGTGCGAGCCAGCATACAGCGAGACCCTTCATGTGTCTCTGGATGCACATATATCTTCCCAACCTTAAACACAG
CTCATTGAAATACATTAAAGCTACTGAAAGTGAGTTCTGATGCAAAACACATGTGAGGTGTGTAGGAACAATGAAAAGCTAGAGGATCTG
GAGTTAGAGGAGGCATTGAGAGTGCTTTTCCCTTAAACGCCGTGATAGTCCTCCCTTGATCTAGAAGTATTCTCTTTGAATCCTTCCATC
TCTTCCTCCTGGTACACCAGATGACTTCATCAGCATCTCCCTCTTTTATGCTAACACCTTTCGCTGTCAACTTTTGAGACCTCCCCATGT
ATCTATAAGCTTCCCAGTCTCTTATGGCAAATTTAAAAGTTTACAAATAGGTTCTCTCATTGAAAAAAAGCATTGTAGTAAAGTTTAAAG
TGGAGCTCAGACAAATCATGACTTATTAAGAGACTACAGGAAGCCATTCAGCATTTAATAATAACTGTTTACAACATGAGGCAAAGCTAA
TAATGTTATGGTTTTATTAAGAGATCTGTCATCTCTGTTTTTCTTAAACTGGTTTAACAGTCAGAGCTTTGTAATGTGTTTCAGCTGAAG
ATTTATTATAGGCTTGTAAATTATCTAAATGTTCTTTTTAGACCCCATGACAGGAGCACAGAGGAACTGAGATAACTCTGTGTTATGAGA
GGGTGGATGCTGGCTTGTGCCAAAATTATTTTAGAGTCCTGCTCTTTAGGGAAAACTTTGCTATGGTAATGTTTCTTTGAAAACAAATTT
ACCAGCAACTGCGTTACTTGGTGTTTTCCAAAGTACAACATCCAAGGCTTGAACCTTACCCGTTTCTAGGCCAGACTAGGCCAGCCTCTA
GTTTTGATAATAATTCATACCTTTATTGGAATATATTTTGGATAGCAGTGAAGAATTGAAAGCAGCTCCTAAAGATTGGTTTGTTTGCTT
TGAAAATGTTTACACTTATTCACTCTAAGCAGTGGACCATTTTGATATCAGGCCCTATACATAAGACCAAAACCAGAAATATTTCTAAAT
CTCAAAGATTTATAAGTACAGTACCTCTGGCTGAAAACTCGTTAAACATCTTTGGATATTTTTTCTTTATATCTTTATGTAATTATTTCT
GTAATTAAGTGTACATTAGGGTTATTTGCTACTTAACAAGCCTAAAGGTATAGCTGTATATAGAATGTGCTCTGTGTTTTTCTGTTTCCT
GCTTGGTTTGTTTCTGGTATGACTATGTCTACTTTTTATTTAAGGAATTTTGTGTAGATAATACTCTCACTAACTTGTAAATAGGATAAG
TTATGAGATTTTTTGGTATTAGAATTTGTAATAATAATGACTTTTAGATTTTATTTGAAAAAGCTACTTGGAAAGCAGTAAATAGAACTA
TAGTGATATATATAGATACATAGATATATACTTTTTTCTGAGAATGTATAATATATAATTGTCAAAGATTTTTGGAAGTCTTTCAAAATA
TACTTAATACCATTTTGAGAACATACCTTCTAATTTATTTCCATAAGGCTGAAGAACTTTTATTTACAAAATGTAAGACTAGATAATGTA
TGAATCAGTGTTACTAGGACTTATCAGTACTTAAAATAGCAACTTGGCATTCTTTATTTTGTTTCCTGGTTGTTTTATTTGGAGGGATAA
TAAATGTCTAAGTTATTTCCATTAAAATTTTGAAATGTTTGTATACTTTATGTGTGCCATTTTAAAGTATATGCAAGTTCTAAGCAATAA
TCTGCATGTTATACAAGGTTGACATATTTTGTCCTGAAATTTTTAGTTAACATTTCAAGAATGATAAAATGAACACCCTGTAAATTACCC
TTCTCCCCCTCCCCTCCATGAAAACCTTGGGATTTTCTTGTGCTAGAACACTACCACAATGTGGTGCAAAGCTTTGTATTTTGTGGAAAA

>69846_69846_1_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000370197_TMEM56_chr1_95657106_ENST00000370203_length(amino acids)=100AA_BP=
MKYPKFSKAIVINGILMTVVFFIVRIASMLPHYGFMYSVYGTEPYIRLGVLIQLSWVISCVVLDVMNVMWMIKISKGCIKVISHIRQEKA

--------------------------------------------------------------
>69846_69846_2_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000370198_TMEM56_chr1_95657106_ENST00000370203_length(transcript)=6152nt_BP=94nt
GGCTCGCTGGCTGCGTGGCTCGGTTCTTGTGAGCGAAGCTTTGTCCGGTTCGGCAATGGACGGAATCGTCACTGAGGTTGCAGTTGGCGT
GAAGGTGGTTCTTTGAAGCTCTGAAGTATCCCAAGTTTTCTAAAGCTATCGTTATCAATGGAATACTCATGACAGTAGTATTCTTCATCG
TGCGGATTGCCTCAATGCTTCCTCATTATGGCTTCATGTATTCCGTGTATGGAACAGAACCCTACATAAGGCTTGGAGTTTTAATCCAGT
TATCCTGGGTCATTAGTTGTGTTGTTTTGGATGTGATGAATGTCATGTGGATGATCAAAATTTCAAAAGGTTGCATCAAAGTCATCTCTC
ACATCAGACAAGAGAAAGCCAAAAATAGTCTTCAGAATGGAAAACTTGATTAAAAGAGTGCTACCGATAAGCAAACTTCATTACTACCCA
GCATATCTGCTGATAGGATGAATTCTTGGCATGTTCTTGTGTACCTTTCTTAATTATAATTGTTATTCAGGATTTCAGTGTCATTTTTTT
TAAACCTTAGAAAAGAGAAGGCCGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTCGATCACTGAGGTC
AGGAGTTCGAGACTAGCTTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAAAAAGTAGCTGGGCGTGGTGGTTGGCGCCT
GTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGAGAGACGGAGGTTGCAGTGAGCTGATATTGTGCCACTGCAC
TCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGAGAGAAACTAAAATTAAAATTTAGTTTTCATCCCAAGATGTC
TTTTCTGCCTTTCTTTTGCCTTATTTACAAGCATGGATAAAAATCTTAAAGGTTTAAATAAAAATGATCAATATAATGGTGAATCTTTTG
AGAAATCTCTTAACTGCATTGGTATTTTTTCTCTGTGAAAGATGACTATGATAATCTGGTACAAATGGTTTTATGTCACCAATTTTGCTG
CAAGAATGGGAACTGCTTTTAAATCTGTAAATAGCTCTTAACATTTGTTGTATGCACTCTTTTCTTACTATGGCTGTCAACACTTGTGTA
GGGTTTAATTTCTAAATTGTTGGCATGTTCTTTTTCTCAGGCTATTCAGAAGTAACAACATTTTTCATTTCAGACATGCAATCACCTATT
AATGATGAAATATTTTACCACTTTGGGAATATTTAATTAGTTTAGTCATGGAGAATACTTCCCACATTTTAAGATTTTTTCAAATATCAC
TGTCATTTCTATTTTAGCATTTTATCAAATTATTGCTTTTTTATTTTATAATAAGGCTTAAGACAGATTATAGACCTCCTTAAGAGATGA
GTTTCTTCTTCTAAAAATGCATGTTGATAGAGGACTATTTAGGCTAATCGGAGGAATCATTAAGAAAGAAAGTTTTAACACTGTTTATCC
CTATCTGCTTTCCTTGCACTTTTTCTGTGAAAAATATTTTCTGTTTGCAAAATCTTCCCTGAGTTCTGAACCCAGCACCATCAGTACCAA
AGTCTTATGCAATATGTATTTATTATGCTCCTGAAATAGGCCTCTTCTTGATGAGACCCAAACTATTACAAAAATATCAGTATTCATATT
TTACTCACAATTCATACCCGTGCTTACTTAGTTGGCATTTTAGTGCTTTGAATTTCTATCTTAAAGCACAGAAAAAAAAAGGTAATTTAA
TCCAAGTATTCTATCATCAAAATTATTGTCTGATTATATGAAGATAAATGACTGGCGACTCTGGTTGTGTGTGTATGTGTTTTGCTTTTA
CTTTAATTCTTGCAATCCAAATATAGAATTATATATTTATCTATTATTGCCTTTATTCTTTAAGCACTTGAGTTTAATGATTATTCTTAC
CTGAGAAAGGAAGAAATTTAATTCTACCAGTGATGAATACTTGAAATTAATTGAACTCATACCAAAAGATGTAATCCAGTTTCTCAGTTT
GAAGGAGAACGTTTGACTCACTTTCATTGTTCATGCTAGCTGAATATAATCAAGACTTTTGATTTGATTTGCTTTTATTATTCAATGCAG
ATAGAGCCTGATAAGTTTTAGAACATTTAAAGAAGATTGAAATCTCAGTCAGTAACTAAATGATAAAATGAGATTGATTGGCTTATACTA
GGTACATTTATTTTTGAAAGAATTAATGTAAAATAATAGTTATTTTTAAAGCAGCTAATATTACACTGATAATTTGTTGCTAAATTTAGT
GCTGTCCACATCATAGGTGCTTAAATATGTACTGGTTAACTAGAGGGGGGTAGGAAAGCAAGCGGTTTTATCTTGTTCTTACCTTTTTGC
AGGAAAAGTGGCTTTAAAAAAATTTATATAATAAAACTATTTTGGAAATTCATTCTTTTAGAAAGAGACCTTGAGATAAATATTTTTTGA
CTCTGGATATTTCTATAGTTCTGAACACAGATTTTAAACCCACTATCAAAATGAAAACAATATAAAGCTATATTAGTGAGTCTCCATGTA
GCAGTTTGTTTTTATAGTTACTGTTTCATGCTTAAAACTTCATTCTTACTTTCATTAATGTTACCCTTCACTGGTATAGCCACTCACTAA
ATAAGTATATTTAAAACATCAAAATTTTGAACTAAAGTTTGTGATTCTCTTATTCAGCAATCCTTATCTTATGCTGGCTGCATGAGTTAA
TTCAACATCCAGATTAAATATCCTGAAGTAGGTTCTATATATTTCCTCATACAACAGACATGGAATGGAAATGCCACTAGAAACTGCCCT
GCTACTTTTAAGTCTGACCTTTGCAGGAGGTACACTTTGCTGTTCTATGATTGTATTCACCTACCTAAAATACAAATGAAGACAGAACAT
ATCATTTACTGCACGATGAATTTTTCATTTATTAAATGAAAAACGTTTGCTAGACATTTTAAATATTAAGTATTTTGACTACACGGATTA
ATTTAAATGATTCTATCAGGCATTCTGATATTTAACAACTCTATTAAAATATTTATAGAAAAATAAAAGCAAATTGATATAAATTTTTGA
GCAATTCTATTTTTGTAGAAAAAAGATAACCTGTAATTATAAAGATGTTTTTTGAATGTGTAGTATCCTAGAAAATAAAAGTTCTTGTGA
AACTTAAAAAATGAATGAAAACCAACTAATAGCATGCAAGATCATAGATCCTGCATTAAATTTTTATTTGTGAAAATTTGAAAATTATGA
GCTATAACTTATAAAGTTTGCCTTCTTATGTCTAAAATCTTTTAAAGGATTATTTGCATTTATGTAAAACTGGAAATGAAGTTATATATG
AGTGCAAAGAAATTGACTTCTGCTCAAATATGTGTTGATACCCTACAGTAAATTGAATTAAATTTTTATCCCAACTGTTTGATTTTATTA
TTTCATGGACTAGCCTTACGTTAAGTGAAATACTATTTATGTTGTTACCACCCCTAAGAGTGACTCTGATATATTATGGATGACCCAGGA
CGGTCTTAAAGGTCTAGTTTTAAAAACTGCCTAGTTTGTAAGTATTTGAATCCAGTTCTTTTCTAAATTTTAATAATTTGACTCAAAATT
TTTGCTACAGGGTCAACTTTTAAATTGTATATTTCCTCTGAGGCACACTGGGCATTTGGAGAATGGTTCTTCACTGGTGTAGAGAGCCAG
GTTTACTGTTGGTTGCACCATCTGTTATCAGGCATGCAGAAACATTTTTCTTCTGGAGAAACAGAGGGGAAGGTGTTGTTACAGTGTACA
TGTTTCCTCTGTGTCGTTTTTAAGGGAAATAAACATGTTCCAAAAGATGCTGTTAAAATAAATATTTGAACACGTTTTCTGTTTCTAGGT
TGCTCTTAATTCCAAACATTTAAATAAATGTGCATTTGAATAGCTTTAGGTGGTTTAGTCTATTAGCTGAAATGGAAAAGTTCATGTATT
GACATCATCAATAATACTTCATAAAGGTTTATGTATTTTTATGTGTTTGGATTCCATAAGAAGTTGAACTTAGATAATTTTATCAAGAGT
AGCACAGTGTTTCTCAGGTGCGAGCCAGCATACAGCGAGACCCTTCATGTGTCTCTGGATGCACATATATCTTCCCAACCTTAAACACAG
CTCATTGAAATACATTAAAGCTACTGAAAGTGAGTTCTGATGCAAAACACATGTGAGGTGTGTAGGAACAATGAAAAGCTAGAGGATCTG
GAGTTAGAGGAGGCATTGAGAGTGCTTTTCCCTTAAACGCCGTGATAGTCCTCCCTTGATCTAGAAGTATTCTCTTTGAATCCTTCCATC
TCTTCCTCCTGGTACACCAGATGACTTCATCAGCATCTCCCTCTTTTATGCTAACACCTTTCGCTGTCAACTTTTGAGACCTCCCCATGT
ATCTATAAGCTTCCCAGTCTCTTATGGCAAATTTAAAAGTTTACAAATAGGTTCTCTCATTGAAAAAAAGCATTGTAGTAAAGTTTAAAG
TGGAGCTCAGACAAATCATGACTTATTAAGAGACTACAGGAAGCCATTCAGCATTTAATAATAACTGTTTACAACATGAGGCAAAGCTAA
TAATGTTATGGTTTTATTAAGAGATCTGTCATCTCTGTTTTTCTTAAACTGGTTTAACAGTCAGAGCTTTGTAATGTGTTTCAGCTGAAG
ATTTATTATAGGCTTGTAAATTATCTAAATGTTCTTTTTAGACCCCATGACAGGAGCACAGAGGAACTGAGATAACTCTGTGTTATGAGA
GGGTGGATGCTGGCTTGTGCCAAAATTATTTTAGAGTCCTGCTCTTTAGGGAAAACTTTGCTATGGTAATGTTTCTTTGAAAACAAATTT
ACCAGCAACTGCGTTACTTGGTGTTTTCCAAAGTACAACATCCAAGGCTTGAACCTTACCCGTTTCTAGGCCAGACTAGGCCAGCCTCTA
GTTTTGATAATAATTCATACCTTTATTGGAATATATTTTGGATAGCAGTGAAGAATTGAAAGCAGCTCCTAAAGATTGGTTTGTTTGCTT
TGAAAATGTTTACACTTATTCACTCTAAGCAGTGGACCATTTTGATATCAGGCCCTATACATAAGACCAAAACCAGAAATATTTCTAAAT
CTCAAAGATTTATAAGTACAGTACCTCTGGCTGAAAACTCGTTAAACATCTTTGGATATTTTTTCTTTATATCTTTATGTAATTATTTCT
GTAATTAAGTGTACATTAGGGTTATTTGCTACTTAACAAGCCTAAAGGTATAGCTGTATATAGAATGTGCTCTGTGTTTTTCTGTTTCCT
GCTTGGTTTGTTTCTGGTATGACTATGTCTACTTTTTATTTAAGGAATTTTGTGTAGATAATACTCTCACTAACTTGTAAATAGGATAAG
TTATGAGATTTTTTGGTATTAGAATTTGTAATAATAATGACTTTTAGATTTTATTTGAAAAAGCTACTTGGAAAGCAGTAAATAGAACTA
TAGTGATATATATAGATACATAGATATATACTTTTTTCTGAGAATGTATAATATATAATTGTCAAAGATTTTTGGAAGTCTTTCAAAATA
TACTTAATACCATTTTGAGAACATACCTTCTAATTTATTTCCATAAGGCTGAAGAACTTTTATTTACAAAATGTAAGACTAGATAATGTA
TGAATCAGTGTTACTAGGACTTATCAGTACTTAAAATAGCAACTTGGCATTCTTTATTTTGTTTCCTGGTTGTTTTATTTGGAGGGATAA
TAAATGTCTAAGTTATTTCCATTAAAATTTTGAAATGTTTGTATACTTTATGTGTGCCATTTTAAAGTATATGCAAGTTCTAAGCAATAA
TCTGCATGTTATACAAGGTTGACATATTTTGTCCTGAAATTTTTAGTTAACATTTCAAGAATGATAAAATGAACACCCTGTAAATTACCC
TTCTCCCCCTCCCCTCCATGAAAACCTTGGGATTTTCTTGTGCTAGAACACTACCACAATGTGGTGCAAAGCTTTGTATTTTGTGGAAAA

>69846_69846_2_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000370198_TMEM56_chr1_95657106_ENST00000370203_length(amino acids)=100AA_BP=
MKYPKFSKAIVINGILMTVVFFIVRIASMLPHYGFMYSVYGTEPYIRLGVLIQLSWVISCVVLDVMNVMWMIKISKGCIKVISHIRQEKA

--------------------------------------------------------------
>69846_69846_3_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000426398_TMEM56_chr1_95657106_ENST00000370203_length(transcript)=6140nt_BP=82nt
GCGTGGCTCGGTTCTTGTGAGCGAAGCTTTGTCCGGTTCGGCAATGGACGGAATCGTCACTGAGGTTGCAGTTGGCGTGAAGGTGGTTCT
TTGAAGCTCTGAAGTATCCCAAGTTTTCTAAAGCTATCGTTATCAATGGAATACTCATGACAGTAGTATTCTTCATCGTGCGGATTGCCT
CAATGCTTCCTCATTATGGCTTCATGTATTCCGTGTATGGAACAGAACCCTACATAAGGCTTGGAGTTTTAATCCAGTTATCCTGGGTCA
TTAGTTGTGTTGTTTTGGATGTGATGAATGTCATGTGGATGATCAAAATTTCAAAAGGTTGCATCAAAGTCATCTCTCACATCAGACAAG
AGAAAGCCAAAAATAGTCTTCAGAATGGAAAACTTGATTAAAAGAGTGCTACCGATAAGCAAACTTCATTACTACCCAGCATATCTGCTG
ATAGGATGAATTCTTGGCATGTTCTTGTGTACCTTTCTTAATTATAATTGTTATTCAGGATTTCAGTGTCATTTTTTTTAAACCTTAGAA
AAGAGAAGGCCGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTCGATCACTGAGGTCAGGAGTTCGAGA
CTAGCTTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAAAAAGTAGCTGGGCGTGGTGGTTGGCGCCTGTAATCCCAGCT
ACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGAGAGACGGAGGTTGCAGTGAGCTGATATTGTGCCACTGCACTCCAGCCTGGGC
GACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGAGAGAAACTAAAATTAAAATTTAGTTTTCATCCCAAGATGTCTTTTCTGCCTTT
CTTTTGCCTTATTTACAAGCATGGATAAAAATCTTAAAGGTTTAAATAAAAATGATCAATATAATGGTGAATCTTTTGAGAAATCTCTTA
ACTGCATTGGTATTTTTTCTCTGTGAAAGATGACTATGATAATCTGGTACAAATGGTTTTATGTCACCAATTTTGCTGCAAGAATGGGAA
CTGCTTTTAAATCTGTAAATAGCTCTTAACATTTGTTGTATGCACTCTTTTCTTACTATGGCTGTCAACACTTGTGTAGGGTTTAATTTC
TAAATTGTTGGCATGTTCTTTTTCTCAGGCTATTCAGAAGTAACAACATTTTTCATTTCAGACATGCAATCACCTATTAATGATGAAATA
TTTTACCACTTTGGGAATATTTAATTAGTTTAGTCATGGAGAATACTTCCCACATTTTAAGATTTTTTCAAATATCACTGTCATTTCTAT
TTTAGCATTTTATCAAATTATTGCTTTTTTATTTTATAATAAGGCTTAAGACAGATTATAGACCTCCTTAAGAGATGAGTTTCTTCTTCT
AAAAATGCATGTTGATAGAGGACTATTTAGGCTAATCGGAGGAATCATTAAGAAAGAAAGTTTTAACACTGTTTATCCCTATCTGCTTTC
CTTGCACTTTTTCTGTGAAAAATATTTTCTGTTTGCAAAATCTTCCCTGAGTTCTGAACCCAGCACCATCAGTACCAAAGTCTTATGCAA
TATGTATTTATTATGCTCCTGAAATAGGCCTCTTCTTGATGAGACCCAAACTATTACAAAAATATCAGTATTCATATTTTACTCACAATT
CATACCCGTGCTTACTTAGTTGGCATTTTAGTGCTTTGAATTTCTATCTTAAAGCACAGAAAAAAAAAGGTAATTTAATCCAAGTATTCT
ATCATCAAAATTATTGTCTGATTATATGAAGATAAATGACTGGCGACTCTGGTTGTGTGTGTATGTGTTTTGCTTTTACTTTAATTCTTG
CAATCCAAATATAGAATTATATATTTATCTATTATTGCCTTTATTCTTTAAGCACTTGAGTTTAATGATTATTCTTACCTGAGAAAGGAA
GAAATTTAATTCTACCAGTGATGAATACTTGAAATTAATTGAACTCATACCAAAAGATGTAATCCAGTTTCTCAGTTTGAAGGAGAACGT
TTGACTCACTTTCATTGTTCATGCTAGCTGAATATAATCAAGACTTTTGATTTGATTTGCTTTTATTATTCAATGCAGATAGAGCCTGAT
AAGTTTTAGAACATTTAAAGAAGATTGAAATCTCAGTCAGTAACTAAATGATAAAATGAGATTGATTGGCTTATACTAGGTACATTTATT
TTTGAAAGAATTAATGTAAAATAATAGTTATTTTTAAAGCAGCTAATATTACACTGATAATTTGTTGCTAAATTTAGTGCTGTCCACATC
ATAGGTGCTTAAATATGTACTGGTTAACTAGAGGGGGGTAGGAAAGCAAGCGGTTTTATCTTGTTCTTACCTTTTTGCAGGAAAAGTGGC
TTTAAAAAAATTTATATAATAAAACTATTTTGGAAATTCATTCTTTTAGAAAGAGACCTTGAGATAAATATTTTTTGACTCTGGATATTT
CTATAGTTCTGAACACAGATTTTAAACCCACTATCAAAATGAAAACAATATAAAGCTATATTAGTGAGTCTCCATGTAGCAGTTTGTTTT
TATAGTTACTGTTTCATGCTTAAAACTTCATTCTTACTTTCATTAATGTTACCCTTCACTGGTATAGCCACTCACTAAATAAGTATATTT
AAAACATCAAAATTTTGAACTAAAGTTTGTGATTCTCTTATTCAGCAATCCTTATCTTATGCTGGCTGCATGAGTTAATTCAACATCCAG
ATTAAATATCCTGAAGTAGGTTCTATATATTTCCTCATACAACAGACATGGAATGGAAATGCCACTAGAAACTGCCCTGCTACTTTTAAG
TCTGACCTTTGCAGGAGGTACACTTTGCTGTTCTATGATTGTATTCACCTACCTAAAATACAAATGAAGACAGAACATATCATTTACTGC
ACGATGAATTTTTCATTTATTAAATGAAAAACGTTTGCTAGACATTTTAAATATTAAGTATTTTGACTACACGGATTAATTTAAATGATT
CTATCAGGCATTCTGATATTTAACAACTCTATTAAAATATTTATAGAAAAATAAAAGCAAATTGATATAAATTTTTGAGCAATTCTATTT
TTGTAGAAAAAAGATAACCTGTAATTATAAAGATGTTTTTTGAATGTGTAGTATCCTAGAAAATAAAAGTTCTTGTGAAACTTAAAAAAT
GAATGAAAACCAACTAATAGCATGCAAGATCATAGATCCTGCATTAAATTTTTATTTGTGAAAATTTGAAAATTATGAGCTATAACTTAT
AAAGTTTGCCTTCTTATGTCTAAAATCTTTTAAAGGATTATTTGCATTTATGTAAAACTGGAAATGAAGTTATATATGAGTGCAAAGAAA
TTGACTTCTGCTCAAATATGTGTTGATACCCTACAGTAAATTGAATTAAATTTTTATCCCAACTGTTTGATTTTATTATTTCATGGACTA
GCCTTACGTTAAGTGAAATACTATTTATGTTGTTACCACCCCTAAGAGTGACTCTGATATATTATGGATGACCCAGGACGGTCTTAAAGG
TCTAGTTTTAAAAACTGCCTAGTTTGTAAGTATTTGAATCCAGTTCTTTTCTAAATTTTAATAATTTGACTCAAAATTTTTGCTACAGGG
TCAACTTTTAAATTGTATATTTCCTCTGAGGCACACTGGGCATTTGGAGAATGGTTCTTCACTGGTGTAGAGAGCCAGGTTTACTGTTGG
TTGCACCATCTGTTATCAGGCATGCAGAAACATTTTTCTTCTGGAGAAACAGAGGGGAAGGTGTTGTTACAGTGTACATGTTTCCTCTGT
GTCGTTTTTAAGGGAAATAAACATGTTCCAAAAGATGCTGTTAAAATAAATATTTGAACACGTTTTCTGTTTCTAGGTTGCTCTTAATTC
CAAACATTTAAATAAATGTGCATTTGAATAGCTTTAGGTGGTTTAGTCTATTAGCTGAAATGGAAAAGTTCATGTATTGACATCATCAAT
AATACTTCATAAAGGTTTATGTATTTTTATGTGTTTGGATTCCATAAGAAGTTGAACTTAGATAATTTTATCAAGAGTAGCACAGTGTTT
CTCAGGTGCGAGCCAGCATACAGCGAGACCCTTCATGTGTCTCTGGATGCACATATATCTTCCCAACCTTAAACACAGCTCATTGAAATA
CATTAAAGCTACTGAAAGTGAGTTCTGATGCAAAACACATGTGAGGTGTGTAGGAACAATGAAAAGCTAGAGGATCTGGAGTTAGAGGAG
GCATTGAGAGTGCTTTTCCCTTAAACGCCGTGATAGTCCTCCCTTGATCTAGAAGTATTCTCTTTGAATCCTTCCATCTCTTCCTCCTGG
TACACCAGATGACTTCATCAGCATCTCCCTCTTTTATGCTAACACCTTTCGCTGTCAACTTTTGAGACCTCCCCATGTATCTATAAGCTT
CCCAGTCTCTTATGGCAAATTTAAAAGTTTACAAATAGGTTCTCTCATTGAAAAAAAGCATTGTAGTAAAGTTTAAAGTGGAGCTCAGAC
AAATCATGACTTATTAAGAGACTACAGGAAGCCATTCAGCATTTAATAATAACTGTTTACAACATGAGGCAAAGCTAATAATGTTATGGT
TTTATTAAGAGATCTGTCATCTCTGTTTTTCTTAAACTGGTTTAACAGTCAGAGCTTTGTAATGTGTTTCAGCTGAAGATTTATTATAGG
CTTGTAAATTATCTAAATGTTCTTTTTAGACCCCATGACAGGAGCACAGAGGAACTGAGATAACTCTGTGTTATGAGAGGGTGGATGCTG
GCTTGTGCCAAAATTATTTTAGAGTCCTGCTCTTTAGGGAAAACTTTGCTATGGTAATGTTTCTTTGAAAACAAATTTACCAGCAACTGC
GTTACTTGGTGTTTTCCAAAGTACAACATCCAAGGCTTGAACCTTACCCGTTTCTAGGCCAGACTAGGCCAGCCTCTAGTTTTGATAATA
ATTCATACCTTTATTGGAATATATTTTGGATAGCAGTGAAGAATTGAAAGCAGCTCCTAAAGATTGGTTTGTTTGCTTTGAAAATGTTTA
CACTTATTCACTCTAAGCAGTGGACCATTTTGATATCAGGCCCTATACATAAGACCAAAACCAGAAATATTTCTAAATCTCAAAGATTTA
TAAGTACAGTACCTCTGGCTGAAAACTCGTTAAACATCTTTGGATATTTTTTCTTTATATCTTTATGTAATTATTTCTGTAATTAAGTGT
ACATTAGGGTTATTTGCTACTTAACAAGCCTAAAGGTATAGCTGTATATAGAATGTGCTCTGTGTTTTTCTGTTTCCTGCTTGGTTTGTT
TCTGGTATGACTATGTCTACTTTTTATTTAAGGAATTTTGTGTAGATAATACTCTCACTAACTTGTAAATAGGATAAGTTATGAGATTTT
TTGGTATTAGAATTTGTAATAATAATGACTTTTAGATTTTATTTGAAAAAGCTACTTGGAAAGCAGTAAATAGAACTATAGTGATATATA
TAGATACATAGATATATACTTTTTTCTGAGAATGTATAATATATAATTGTCAAAGATTTTTGGAAGTCTTTCAAAATATACTTAATACCA
TTTTGAGAACATACCTTCTAATTTATTTCCATAAGGCTGAAGAACTTTTATTTACAAAATGTAAGACTAGATAATGTATGAATCAGTGTT
ACTAGGACTTATCAGTACTTAAAATAGCAACTTGGCATTCTTTATTTTGTTTCCTGGTTGTTTTATTTGGAGGGATAATAAATGTCTAAG
TTATTTCCATTAAAATTTTGAAATGTTTGTATACTTTATGTGTGCCATTTTAAAGTATATGCAAGTTCTAAGCAATAATCTGCATGTTAT
ACAAGGTTGACATATTTTGTCCTGAAATTTTTAGTTAACATTTCAAGAATGATAAAATGAACACCCTGTAAATTACCCTTCTCCCCCTCC
CCTCCATGAAAACCTTGGGATTTTCTTGTGCTAGAACACTACCACAATGTGGTGCAAAGCTTTGTATTTTGTGGAAAAAAACAATAAAAT

>69846_69846_3_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000426398_TMEM56_chr1_95657106_ENST00000370203_length(amino acids)=100AA_BP=
MKYPKFSKAIVINGILMTVVFFIVRIASMLPHYGFMYSVYGTEPYIRLGVLIQLSWVISCVVLDVMNVMWMIKISKGCIKVISHIRQEKA

--------------------------------------------------------------
>69846_69846_4_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000609116_TMEM56_chr1_95657106_ENST00000370203_length(transcript)=6179nt_BP=121nt
CAGCCGCCATTTTCTCGCCGCTTGTGTGGCTCGCTGGCTGCGTGGCTCGGTTCTTGTGAGCGAAGCTTTGTCCGGTTCGGCAATGGACGG
AATCGTCACTGAGGTTGCAGTTGGCGTGAAGGTGGTTCTTTGAAGCTCTGAAGTATCCCAAGTTTTCTAAAGCTATCGTTATCAATGGAA
TACTCATGACAGTAGTATTCTTCATCGTGCGGATTGCCTCAATGCTTCCTCATTATGGCTTCATGTATTCCGTGTATGGAACAGAACCCT
ACATAAGGCTTGGAGTTTTAATCCAGTTATCCTGGGTCATTAGTTGTGTTGTTTTGGATGTGATGAATGTCATGTGGATGATCAAAATTT
CAAAAGGTTGCATCAAAGTCATCTCTCACATCAGACAAGAGAAAGCCAAAAATAGTCTTCAGAATGGAAAACTTGATTAAAAGAGTGCTA
CCGATAAGCAAACTTCATTACTACCCAGCATATCTGCTGATAGGATGAATTCTTGGCATGTTCTTGTGTACCTTTCTTAATTATAATTGT
TATTCAGGATTTCAGTGTCATTTTTTTTAAACCTTAGAAAAGAGAAGGCCGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA
GGCCAAGGTGGGTCGATCACTGAGGTCAGGAGTTCGAGACTAGCTTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAAAA
AGTAGCTGGGCGTGGTGGTTGGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGAGAGACGGAGGTTG
CAGTGAGCTGATATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGAGAGAAACTAAAATT
AAAATTTAGTTTTCATCCCAAGATGTCTTTTCTGCCTTTCTTTTGCCTTATTTACAAGCATGGATAAAAATCTTAAAGGTTTAAATAAAA
ATGATCAATATAATGGTGAATCTTTTGAGAAATCTCTTAACTGCATTGGTATTTTTTCTCTGTGAAAGATGACTATGATAATCTGGTACA
AATGGTTTTATGTCACCAATTTTGCTGCAAGAATGGGAACTGCTTTTAAATCTGTAAATAGCTCTTAACATTTGTTGTATGCACTCTTTT
CTTACTATGGCTGTCAACACTTGTGTAGGGTTTAATTTCTAAATTGTTGGCATGTTCTTTTTCTCAGGCTATTCAGAAGTAACAACATTT
TTCATTTCAGACATGCAATCACCTATTAATGATGAAATATTTTACCACTTTGGGAATATTTAATTAGTTTAGTCATGGAGAATACTTCCC
ACATTTTAAGATTTTTTCAAATATCACTGTCATTTCTATTTTAGCATTTTATCAAATTATTGCTTTTTTATTTTATAATAAGGCTTAAGA
CAGATTATAGACCTCCTTAAGAGATGAGTTTCTTCTTCTAAAAATGCATGTTGATAGAGGACTATTTAGGCTAATCGGAGGAATCATTAA
GAAAGAAAGTTTTAACACTGTTTATCCCTATCTGCTTTCCTTGCACTTTTTCTGTGAAAAATATTTTCTGTTTGCAAAATCTTCCCTGAG
TTCTGAACCCAGCACCATCAGTACCAAAGTCTTATGCAATATGTATTTATTATGCTCCTGAAATAGGCCTCTTCTTGATGAGACCCAAAC
TATTACAAAAATATCAGTATTCATATTTTACTCACAATTCATACCCGTGCTTACTTAGTTGGCATTTTAGTGCTTTGAATTTCTATCTTA
AAGCACAGAAAAAAAAAGGTAATTTAATCCAAGTATTCTATCATCAAAATTATTGTCTGATTATATGAAGATAAATGACTGGCGACTCTG
GTTGTGTGTGTATGTGTTTTGCTTTTACTTTAATTCTTGCAATCCAAATATAGAATTATATATTTATCTATTATTGCCTTTATTCTTTAA
GCACTTGAGTTTAATGATTATTCTTACCTGAGAAAGGAAGAAATTTAATTCTACCAGTGATGAATACTTGAAATTAATTGAACTCATACC
AAAAGATGTAATCCAGTTTCTCAGTTTGAAGGAGAACGTTTGACTCACTTTCATTGTTCATGCTAGCTGAATATAATCAAGACTTTTGAT
TTGATTTGCTTTTATTATTCAATGCAGATAGAGCCTGATAAGTTTTAGAACATTTAAAGAAGATTGAAATCTCAGTCAGTAACTAAATGA
TAAAATGAGATTGATTGGCTTATACTAGGTACATTTATTTTTGAAAGAATTAATGTAAAATAATAGTTATTTTTAAAGCAGCTAATATTA
CACTGATAATTTGTTGCTAAATTTAGTGCTGTCCACATCATAGGTGCTTAAATATGTACTGGTTAACTAGAGGGGGGTAGGAAAGCAAGC
GGTTTTATCTTGTTCTTACCTTTTTGCAGGAAAAGTGGCTTTAAAAAAATTTATATAATAAAACTATTTTGGAAATTCATTCTTTTAGAA
AGAGACCTTGAGATAAATATTTTTTGACTCTGGATATTTCTATAGTTCTGAACACAGATTTTAAACCCACTATCAAAATGAAAACAATAT
AAAGCTATATTAGTGAGTCTCCATGTAGCAGTTTGTTTTTATAGTTACTGTTTCATGCTTAAAACTTCATTCTTACTTTCATTAATGTTA
CCCTTCACTGGTATAGCCACTCACTAAATAAGTATATTTAAAACATCAAAATTTTGAACTAAAGTTTGTGATTCTCTTATTCAGCAATCC
TTATCTTATGCTGGCTGCATGAGTTAATTCAACATCCAGATTAAATATCCTGAAGTAGGTTCTATATATTTCCTCATACAACAGACATGG
AATGGAAATGCCACTAGAAACTGCCCTGCTACTTTTAAGTCTGACCTTTGCAGGAGGTACACTTTGCTGTTCTATGATTGTATTCACCTA
CCTAAAATACAAATGAAGACAGAACATATCATTTACTGCACGATGAATTTTTCATTTATTAAATGAAAAACGTTTGCTAGACATTTTAAA
TATTAAGTATTTTGACTACACGGATTAATTTAAATGATTCTATCAGGCATTCTGATATTTAACAACTCTATTAAAATATTTATAGAAAAA
TAAAAGCAAATTGATATAAATTTTTGAGCAATTCTATTTTTGTAGAAAAAAGATAACCTGTAATTATAAAGATGTTTTTTGAATGTGTAG
TATCCTAGAAAATAAAAGTTCTTGTGAAACTTAAAAAATGAATGAAAACCAACTAATAGCATGCAAGATCATAGATCCTGCATTAAATTT
TTATTTGTGAAAATTTGAAAATTATGAGCTATAACTTATAAAGTTTGCCTTCTTATGTCTAAAATCTTTTAAAGGATTATTTGCATTTAT
GTAAAACTGGAAATGAAGTTATATATGAGTGCAAAGAAATTGACTTCTGCTCAAATATGTGTTGATACCCTACAGTAAATTGAATTAAAT
TTTTATCCCAACTGTTTGATTTTATTATTTCATGGACTAGCCTTACGTTAAGTGAAATACTATTTATGTTGTTACCACCCCTAAGAGTGA
CTCTGATATATTATGGATGACCCAGGACGGTCTTAAAGGTCTAGTTTTAAAAACTGCCTAGTTTGTAAGTATTTGAATCCAGTTCTTTTC
TAAATTTTAATAATTTGACTCAAAATTTTTGCTACAGGGTCAACTTTTAAATTGTATATTTCCTCTGAGGCACACTGGGCATTTGGAGAA
TGGTTCTTCACTGGTGTAGAGAGCCAGGTTTACTGTTGGTTGCACCATCTGTTATCAGGCATGCAGAAACATTTTTCTTCTGGAGAAACA
GAGGGGAAGGTGTTGTTACAGTGTACATGTTTCCTCTGTGTCGTTTTTAAGGGAAATAAACATGTTCCAAAAGATGCTGTTAAAATAAAT
ATTTGAACACGTTTTCTGTTTCTAGGTTGCTCTTAATTCCAAACATTTAAATAAATGTGCATTTGAATAGCTTTAGGTGGTTTAGTCTAT
TAGCTGAAATGGAAAAGTTCATGTATTGACATCATCAATAATACTTCATAAAGGTTTATGTATTTTTATGTGTTTGGATTCCATAAGAAG
TTGAACTTAGATAATTTTATCAAGAGTAGCACAGTGTTTCTCAGGTGCGAGCCAGCATACAGCGAGACCCTTCATGTGTCTCTGGATGCA
CATATATCTTCCCAACCTTAAACACAGCTCATTGAAATACATTAAAGCTACTGAAAGTGAGTTCTGATGCAAAACACATGTGAGGTGTGT
AGGAACAATGAAAAGCTAGAGGATCTGGAGTTAGAGGAGGCATTGAGAGTGCTTTTCCCTTAAACGCCGTGATAGTCCTCCCTTGATCTA
GAAGTATTCTCTTTGAATCCTTCCATCTCTTCCTCCTGGTACACCAGATGACTTCATCAGCATCTCCCTCTTTTATGCTAACACCTTTCG
CTGTCAACTTTTGAGACCTCCCCATGTATCTATAAGCTTCCCAGTCTCTTATGGCAAATTTAAAAGTTTACAAATAGGTTCTCTCATTGA
AAAAAAGCATTGTAGTAAAGTTTAAAGTGGAGCTCAGACAAATCATGACTTATTAAGAGACTACAGGAAGCCATTCAGCATTTAATAATA
ACTGTTTACAACATGAGGCAAAGCTAATAATGTTATGGTTTTATTAAGAGATCTGTCATCTCTGTTTTTCTTAAACTGGTTTAACAGTCA
GAGCTTTGTAATGTGTTTCAGCTGAAGATTTATTATAGGCTTGTAAATTATCTAAATGTTCTTTTTAGACCCCATGACAGGAGCACAGAG
GAACTGAGATAACTCTGTGTTATGAGAGGGTGGATGCTGGCTTGTGCCAAAATTATTTTAGAGTCCTGCTCTTTAGGGAAAACTTTGCTA
TGGTAATGTTTCTTTGAAAACAAATTTACCAGCAACTGCGTTACTTGGTGTTTTCCAAAGTACAACATCCAAGGCTTGAACCTTACCCGT
TTCTAGGCCAGACTAGGCCAGCCTCTAGTTTTGATAATAATTCATACCTTTATTGGAATATATTTTGGATAGCAGTGAAGAATTGAAAGC
AGCTCCTAAAGATTGGTTTGTTTGCTTTGAAAATGTTTACACTTATTCACTCTAAGCAGTGGACCATTTTGATATCAGGCCCTATACATA
AGACCAAAACCAGAAATATTTCTAAATCTCAAAGATTTATAAGTACAGTACCTCTGGCTGAAAACTCGTTAAACATCTTTGGATATTTTT
TCTTTATATCTTTATGTAATTATTTCTGTAATTAAGTGTACATTAGGGTTATTTGCTACTTAACAAGCCTAAAGGTATAGCTGTATATAG
AATGTGCTCTGTGTTTTTCTGTTTCCTGCTTGGTTTGTTTCTGGTATGACTATGTCTACTTTTTATTTAAGGAATTTTGTGTAGATAATA
CTCTCACTAACTTGTAAATAGGATAAGTTATGAGATTTTTTGGTATTAGAATTTGTAATAATAATGACTTTTAGATTTTATTTGAAAAAG
CTACTTGGAAAGCAGTAAATAGAACTATAGTGATATATATAGATACATAGATATATACTTTTTTCTGAGAATGTATAATATATAATTGTC
AAAGATTTTTGGAAGTCTTTCAAAATATACTTAATACCATTTTGAGAACATACCTTCTAATTTATTTCCATAAGGCTGAAGAACTTTTAT
TTACAAAATGTAAGACTAGATAATGTATGAATCAGTGTTACTAGGACTTATCAGTACTTAAAATAGCAACTTGGCATTCTTTATTTTGTT
TCCTGGTTGTTTTATTTGGAGGGATAATAAATGTCTAAGTTATTTCCATTAAAATTTTGAAATGTTTGTATACTTTATGTGTGCCATTTT
AAAGTATATGCAAGTTCTAAGCAATAATCTGCATGTTATACAAGGTTGACATATTTTGTCCTGAAATTTTTAGTTAACATTTCAAGAATG
ATAAAATGAACACCCTGTAAATTACCCTTCTCCCCCTCCCCTCCATGAAAACCTTGGGATTTTCTTGTGCTAGAACACTACCACAATGTG

>69846_69846_4_PTBP2-TMEM56_PTBP2_chr1_97189150_ENST00000609116_TMEM56_chr1_95657106_ENST00000370203_length(amino acids)=100AA_BP=
MKYPKFSKAIVINGILMTVVFFIVRIASMLPHYGFMYSVYGTEPYIRLGVLIQLSWVISCVVLDVMNVMWMIKISKGCIKVISHIRQEKA

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Fusion Gene PPI Analysis for PTBP2-TMEM56


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTBP2-TMEM56


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTBP2-TMEM56


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource