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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PTBP3-ARID5A (FusionGDB2 ID:69847)

Fusion Gene Summary for PTBP3-ARID5A

Fusion gene summary

Fusion gene information	Fusion gene name: PTBP3-ARID5A
	Fusion gene ID: 69847
		Hgene	Tgene
	Gene symbol	PTBP3	ARID5A
	Gene ID	9991	10865
	Gene name	polypyrimidine tract binding protein 3	AT-rich interaction domain 5A
	Synonyms	ROD1	MRF-1\|MRF1\|RP11-363D14
	Cytomap	9q32	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	polypyrimidine tract-binding protein 3ROD1 regulator of differentiation 1fission yeast differentiation regulatorregulator of differentiation 1	AT-rich interactive domain-containing protein 5AARID domain-containing protein 5AAT rich interactive domain 5A (MRF1-like)RFVG5814modulator recognition factor 1modulator recognition factor I
	Modification date	20200313	20200320
	UniProtAcc	.	Q03989
	Ensembl transtripts involved in fusion gene	ENST00000374255, ENST00000458258, ENST00000334318, ENST00000343327, ENST00000374257, ENST00000487997,	ENST00000454558, ENST00000357485,
Fusion gene scores	* DoF score	11 X 13 X 8=1144	2 X 1 X 2=4
	# samples	17	2
	** MAII score	log2(17/1144*10)=-2.75048040064069 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: PTBP3 [Title/Abstract] AND ARID5A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PTBP3(115060121)-ARID5A(97213139), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTBP3	GO:0033119	negative regulation of RNA splicing	18335065
Tgene	ARID5A	GO:0000122	negative regulation of transcription by RNA polymerase II	15941852
Tgene	ARID5A	GO:0071391	cellular response to estrogen stimulus	15941852

Fusion gene breakpoints across PTBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARID5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8080-01A	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+

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Fusion Gene ORF analysis for PTBP3-ARID5A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000374255	ENST00000454558	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
5CDS-5UTR	ENST00000458258	ENST00000454558	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
In-frame	ENST00000374255	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
In-frame	ENST00000458258	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-3CDS	ENST00000334318	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-3CDS	ENST00000343327	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-3CDS	ENST00000374257	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-3CDS	ENST00000487997	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-5UTR	ENST00000334318	ENST00000454558	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-5UTR	ENST00000343327	ENST00000454558	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-5UTR	ENST00000374257	ENST00000454558	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+
intron-5UTR	ENST00000487997	ENST00000454558	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000458258

PTBP3

chr9

115060121

ENST00000357485

ARID5A

chr2

97213139

2242

136

1916

638

ENST00000374255

PTBP3

chr9

115060121

ENST00000357485

ARID5A

chr2

97213139

2372

266

148

2046

632

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000458258	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+	0.016550887	0.98344916
ENST00000374255	ENST00000357485	PTBP3	chr9	115060121	-	ARID5A	chr2	97213139	+	0.010913229	0.98908675

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Fusion Genomic Features for PTBP3-ARID5A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PTBP3	chr9	115060120	-	ARID5A	chr2	97213138	+	1.89E-12	1
PTBP3	chr9	115060120	-	ARID5A	chr2	97213138	+	1.89E-12	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTBP3-ARID5A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:115060121/chr2:97213139)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ARID5A Q03989
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). {ECO:0000250\|UniProtKB:Q3U108, ECO:0000269\|PubMed:15941852, ECO:0000269\|PubMed:8649988}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARID5A

chr9:115060121

chr2:97213139

ENST00000357485

55_147

595.0

Domain

ARID

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000334318

182_258

556.0

Domain

RRM 2

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000334318

358_432

556.0

Domain

RRM 3

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000334318

475_550

556.0

Domain

RRM 4

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000334318

59_143

556.0

Domain

RRM 1

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000343327

182_258

458.0

Domain

RRM 2

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000343327

358_432

458.0

Domain

RRM 3

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000343327

475_550

458.0

Domain

RRM 4

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000343327

59_143

458.0

Domain

RRM 1

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374255

182_258

553.0

Domain

RRM 2

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374255

358_432

553.0

Domain

RRM 3

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374255

475_550

553.0

Domain

RRM 4

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374255

59_143

553.0

Domain

RRM 1

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374257

182_258

525.0

Domain

RRM 2

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374257

358_432

525.0

Domain

RRM 3

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374257

475_550

525.0

Domain

RRM 4

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000374257

59_143

525.0

Domain

RRM 1

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000458258

182_258

559.0

Domain

RRM 2

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000458258

358_432

559.0

Domain

RRM 3

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000458258

475_550

559.0

Domain

RRM 4

Hgene

PTBP3

chr9:115060121

chr2:97213139

ENST00000458258

59_143

559.0

Domain

RRM 1

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Fusion Gene Sequence for PTBP3-ARID5A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>69847_69847_1_PTBP3-ARID5A_PTBP3_chr9_115060121_ENST00000374255_ARID5A_chr2_97213139_ENST00000357485_length(transcript)=2372nt_BP=266nt
GTTCCCACTCTCCTTCCACCTCGGACCGGCCGGGGCTCCGCAGAGCCAAAGCTCGCTTGTCCCCGGAACCGCCCTGCTGCCGCCGCCTGC
TTCCTCTGCTCGCGGTTAGCCCGTCAGTCCCTGCTCTGTGCGCGCCTCCATCTGGGCCATGGATGGTGTTGTTACAGATCTTATAACAGT
CGGTTTAAAGCGGGGATCTGATGAGCTTCTTTCTTCTGGCATCATTAACGGACCTTTTACCATGAATAGTTCTACTCCTTCTACAGCAGC
CCCTGTCAAAGGGAACAGGAAGCAGTCCACGGAGGGTGACGCCCTAGACCCACCTGCATCCCCCAAACCTGCTGGCAAGCAGAACGGAAT
CCAGAACCCCATCTCGCTGGAGGACTCCCCCGAGGCAGGCGGGGAGCGGGAGGAGGAGCAGGAGCGGGAGGAGGAGCAGGCCTTCCTGGT
CAGCCTCTACAAGTTCATGAAGGAGCGACACACGCCCATCGAGAGGGTGCCCCATCTCGGCTTCAAGCAGATTAACCTGTGGAAGATCTA
CAAAGCAGTGGAGAAGCTGGGGGCCTATGAGCTGGTGACCGGGCGCCGCCTCTGGAAGAACGTGTACGACGAGCTGGGGGGCAGCCCAGG
CAGCACCAGCGCGGCCACGTGCACGCGCCGCCACTACGAGAGGCTGGTCCTGCCATACGTGCGGCACCTGAAGGGGGAGGATGACAAGCC
GCTGCCCACCTCCAAGCCCAGGAAACAGTACAAGATGGCTAAGGAGAACAGGGGGGATGATGGGGCCACCGAGAGGCCGAAGAAGGCCAA
GGAGGAGCGGCGCATGGACCAGATGATGCCAGGAAAGACCAAAGCAGATGCTGCTGACCCAGCACCACTTCCCAGCCAGGAGCCCCCCAG
GAACAGCACAGAACAGCAGGGCCTGGCCTCTGGGTCTTCTGTGTCCTTTGTGGGTGCCAGCGGCTGTCCTGAGGCCTACAAGCGGCTCCT
ATCCAGCTTCTACTGCAAGGGGACACACGGCATCATGTCACCACTGGCCAAAAAGAAGCTCCTGGCCCAGGTGAGCAAGGTGGAGGCCTT
GCAGTGCCAGGAGGAGGGCTGCCGCCATGGGGCAGAGCCCCAGGCGTCCCCAGCTGTTCACCTCCCAGAGAGTCCCCAGAGCCCCAAAGG
GCTGACTGAGAACTCCAGGCACCGGCTGACCCCTCAGGAGGGATTGCAGGCCCCAGGTGGCAGCCTCAGAGAGGAGGCGCAGGCAGGCCC
CTGCCCGGCAGCCCCCATCTTCAAGGGCTGCTTCTACACCCACCCCACCGAGGTGCTGAAGCCTGTCAGCCAGCACCCCAGGGACTTCTT
CTCTAGACTTAAAGATGGGGTGCTATTGGGGCCTCCTGGCAAAGAGGGGCTGTCAGTGAAAGAGCCCCAGCTGGTGTGGGGCGGAGACGC
TAACCGCCCTTCTGCGTTCCATAAAGGTGGCTCCAGAAAGGGCATCCTCTACCCCAAGCCCAAAGCCTGCTGGGTGTCCCCCATGGCCAA
GGTCCCAGCCGAGAGCCCCACGCTCCCGCCCACCTTCCCCAGTAGCCCAGGCCTGGGCAGCAAGCGCAGCCTGGAGGAAGAGGGTGCTGC
CCACAGTGGGAAGAGACTGCGGGCCGTGTCTCCCTTTCTTAAGGAGGCGGATGCCAAGAAGTGTGGGGCCAAACCTGCAGGGTCCGGCCT
GGTCTCCTGCCTTCTGGGCCCAGCCCTGGGGCCTGTGCCCCCAGAGGCCTACAGGGGCACCATGCTGCACTGCCCGCTGAACTTCACTGG
CACCCCGGGCCCCTTGAAGGGCCAGGCTGCACTCCCCTTCAGCCCCCTGGTCATCCCGGCCTTCCCGGCCCACTTCCTGGCCACCGCAGG
CCCCTCGCCCATGGCCGCTGGCCTGATGCACTTCCCCCCAACGTCCTTCGACAGTGCCCTCCGCCACAGACTTTGCCCGGCCTCATCTGC
CTGGCACGCACCACCAGTCACAACCTATGCAGCGCCCCACTTCTTCCACCTCAACACCAAGCTGTAGGCCAGCCCATGGTGTTGTGTACA
CTGTGGAGTCGACAGGGGCCTACAACAGGCAGGTACTGCTGCCAGGGGGCTCTGAACTAGTGCCTGCTACCCAGGACACCCGGGCCATGC
CCCTGGCTGGGCAGCCTGGCACAAGTGAAGAAGAAGGCAGTGGGAAAACTGGGTTTATCTCAAGGCAGCAGCCTGAGCCCAGGAGCAGAG
GACCCAGTTGTTATAAGGCGCTGGGAGAGGATGGGCAGCTCCCACTGCCCCAGAGCGGAGCTCGAAGCACCCAGGTTGCCCACGGAAAAT

>69847_69847_1_PTBP3-ARID5A_PTBP3_chr9_115060121_ENST00000374255_ARID5A_chr2_97213139_ENST00000357485_length(amino acids)=632AA_BP=39
MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEE
QEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPY
VRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSSVSFVGA
SGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQEGLQAPG
GSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPRDFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRKGILYPK
PKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGLVSCLLGPALGPVPPEAYRG
TMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNT

--------------------------------------------------------------
>69847_69847_2_PTBP3-ARID5A_PTBP3_chr9_115060121_ENST00000458258_ARID5A_chr2_97213139_ENST00000357485_length(transcript)=2242nt_BP=136nt
ATGGACGCTTCCCCCTCACCTTTCTCTCTCCCCAAGAAACTTAATGAATTATCTGCCCGTCGGGGATCTGATGAGCTTCTTTCTTCTGGC
ATCATTAACGGACCTTTTACCATGAATAGTTCTACTCCTTCTACAGCAGCCCCTGTCAAAGGGAACAGGAAGCAGTCCACGGAGGGTGAC
GCCCTAGACCCACCTGCATCCCCCAAACCTGCTGGCAAGCAGAACGGAATCCAGAACCCCATCTCGCTGGAGGACTCCCCCGAGGCAGGC
GGGGAGCGGGAGGAGGAGCAGGAGCGGGAGGAGGAGCAGGCCTTCCTGGTCAGCCTCTACAAGTTCATGAAGGAGCGACACACGCCCATC
GAGAGGGTGCCCCATCTCGGCTTCAAGCAGATTAACCTGTGGAAGATCTACAAAGCAGTGGAGAAGCTGGGGGCCTATGAGCTGGTGACC
GGGCGCCGCCTCTGGAAGAACGTGTACGACGAGCTGGGGGGCAGCCCAGGCAGCACCAGCGCGGCCACGTGCACGCGCCGCCACTACGAG
AGGCTGGTCCTGCCATACGTGCGGCACCTGAAGGGGGAGGATGACAAGCCGCTGCCCACCTCCAAGCCCAGGAAACAGTACAAGATGGCT
AAGGAGAACAGGGGGGATGATGGGGCCACCGAGAGGCCGAAGAAGGCCAAGGAGGAGCGGCGCATGGACCAGATGATGCCAGGAAAGACC
AAAGCAGATGCTGCTGACCCAGCACCACTTCCCAGCCAGGAGCCCCCCAGGAACAGCACAGAACAGCAGGGCCTGGCCTCTGGGTCTTCT
GTGTCCTTTGTGGGTGCCAGCGGCTGTCCTGAGGCCTACAAGCGGCTCCTATCCAGCTTCTACTGCAAGGGGACACACGGCATCATGTCA
CCACTGGCCAAAAAGAAGCTCCTGGCCCAGGTGAGCAAGGTGGAGGCCTTGCAGTGCCAGGAGGAGGGCTGCCGCCATGGGGCAGAGCCC
CAGGCGTCCCCAGCTGTTCACCTCCCAGAGAGTCCCCAGAGCCCCAAAGGGCTGACTGAGAACTCCAGGCACCGGCTGACCCCTCAGGAG
GGATTGCAGGCCCCAGGTGGCAGCCTCAGAGAGGAGGCGCAGGCAGGCCCCTGCCCGGCAGCCCCCATCTTCAAGGGCTGCTTCTACACC
CACCCCACCGAGGTGCTGAAGCCTGTCAGCCAGCACCCCAGGGACTTCTTCTCTAGACTTAAAGATGGGGTGCTATTGGGGCCTCCTGGC
AAAGAGGGGCTGTCAGTGAAAGAGCCCCAGCTGGTGTGGGGCGGAGACGCTAACCGCCCTTCTGCGTTCCATAAAGGTGGCTCCAGAAAG
GGCATCCTCTACCCCAAGCCCAAAGCCTGCTGGGTGTCCCCCATGGCCAAGGTCCCAGCCGAGAGCCCCACGCTCCCGCCCACCTTCCCC
AGTAGCCCAGGCCTGGGCAGCAAGCGCAGCCTGGAGGAAGAGGGTGCTGCCCACAGTGGGAAGAGACTGCGGGCCGTGTCTCCCTTTCTT
AAGGAGGCGGATGCCAAGAAGTGTGGGGCCAAACCTGCAGGGTCCGGCCTGGTCTCCTGCCTTCTGGGCCCAGCCCTGGGGCCTGTGCCC
CCAGAGGCCTACAGGGGCACCATGCTGCACTGCCCGCTGAACTTCACTGGCACCCCGGGCCCCTTGAAGGGCCAGGCTGCACTCCCCTTC
AGCCCCCTGGTCATCCCGGCCTTCCCGGCCCACTTCCTGGCCACCGCAGGCCCCTCGCCCATGGCCGCTGGCCTGATGCACTTCCCCCCA
ACGTCCTTCGACAGTGCCCTCCGCCACAGACTTTGCCCGGCCTCATCTGCCTGGCACGCACCACCAGTCACAACCTATGCAGCGCCCCAC
TTCTTCCACCTCAACACCAAGCTGTAGGCCAGCCCATGGTGTTGTGTACACTGTGGAGTCGACAGGGGCCTACAACAGGCAGGTACTGCT
GCCAGGGGGCTCTGAACTAGTGCCTGCTACCCAGGACACCCGGGCCATGCCCCTGGCTGGGCAGCCTGGCACAAGTGAAGAAGAAGGCAG
TGGGAAAACTGGGTTTATCTCAAGGCAGCAGCCTGAGCCCAGGAGCAGAGGACCCAGTTGTTATAAGGCGCTGGGAGAGGATGGGCAGCT

>69847_69847_2_PTBP3-ARID5A_PTBP3_chr9_115060121_ENST00000458258_ARID5A_chr2_97213139_ENST00000357485_length(amino acids)=638AA_BP=45
MDASPSPFSLPKKLNELSARRGSDELLSSGIINGPFTMNSSTPSTAAPVKGNRKQSTEGDALDPPASPKPAGKQNGIQNPISLEDSPEAG
GEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYE
RLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQMMPGKTKADAADPAPLPSQEPPRNSTEQQGLASGSS
VSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQE
GLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHPRDFFSRLKDGVLLGPPGKEGLSVKEPQLVWGGDANRPSAFHKGGSRK
GILYPKPKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGLVSCLLGPALGPVP
PEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTBP3-ARID5A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ARID5A	chr9:115060121	chr2:97213139	ENST00000357485		0	7	1_300	1.3333333333333333	595.0	SOX9

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PTBP3-ARID5A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PTBP3-ARID5A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source