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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTCH1-IPPK (FusionGDB2 ID:69866)

Fusion Gene Summary for PTCH1-IPPK

check button Fusion gene summary
Fusion gene informationFusion gene name: PTCH1-IPPK
Fusion gene ID: 69866
HgeneTgene
Gene symbol

PTCH1

IPPK

Gene ID

5727

64768

Gene namepatched 1inositol-pentakisphosphate 2-kinase
SynonymsBCNS|NBCCS|PTC|PTC1|PTCHC9orf12|INSP5K2|IP5K|IPK1|bA476B13.1
Cytomap

9q22.32

9q22.31

Type of geneprotein-codingprotein-coding
Descriptionprotein patched homolog 1inositol-pentakisphosphate 2-kinaseIPK1 homologbA476B13.1 (novel protein)inositol 1,3,4,5,6-pentakisphosphate 2-kinaseins(1,3,4,5,6)P5 2-kinaseinsP5 2-kinase
Modification date2020031420200313
UniProtAcc.

Q9H8X2

Ensembl transtripts involved in fusion geneENST00000331920, ENST00000375274, 
ENST00000430669, ENST00000437951, 
ENST00000468211, ENST00000418258, 
ENST00000421141, ENST00000429896, 
ENST00000548379, 		ENST00000375522, 
ENST00000486841, ENST00000287996, 
Fusion gene scores* DoF score6 X 7 X 4=1689 X 9 X 5=405
# samples 79
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTCH1 [Title/Abstract] AND IPPK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTCH1(98268689)-IPPK(95381847), # samples:3
Anticipated loss of major functional domain due to fusion event.PTCH1-IPPK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PTCH1-IPPK seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PTCH1-IPPK seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTCH1

GO:0010875

positive regulation of cholesterol efflux

21931618

HgenePTCH1

GO:0072659

protein localization to plasma membrane

11278759

TgeneIPPK

GO:0052746

inositol phosphorylation

12084730


check buttonFusion gene breakpoints across PTCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IPPK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KZ-01APTCH1chr9

98268689

-IPPKchr9

95381847

-
ChimerDB4SARCTCGA-RN-AAAQ-01APTCH1chr9

98268689

-IPPKchr9

95381847

-


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Fusion Gene ORF analysis for PTCH1-IPPK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000331920ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000331920ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000375274ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000375274ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000430669ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000430669ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000437951ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000437951ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000468211ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000468211ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-3CDSENST00000418258ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-3CDSENST00000421141ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-3CDSENST00000429896ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000418258ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000418258ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000421141ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000421141ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000429896ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000429896ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
Frame-shiftENST00000430669ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
Frame-shiftENST00000468211ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
In-frameENST00000331920ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
In-frameENST00000375274ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
In-frameENST00000437951ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
intron-3CDSENST00000548379ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
intron-5UTRENST00000548379ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
intron-5UTRENST00000548379ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000331920PTCH1chr998268689-ENST00000287996IPPKchr995381847-3648694174779201
ENST00000437951PTCH1chr998268689-ENST00000287996IPPKchr995381847-3644690547155130
ENST00000375274PTCH1chr998268689-ENST00000287996IPPKchr995381847-3490536145621158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331920ENST00000287996PTCH1chr998268689-IPPKchr995381847-0.20751160.79248834
ENST00000437951ENST00000287996PTCH1chr998268689-IPPKchr995381847-0.085903240.9140967
ENST00000375274ENST00000287996PTCH1chr998268689-IPPKchr995381847-0.0090714530.9909286

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Fusion Genomic Features for PTCH1-IPPK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTCH1-IPPK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:98268689/chr9:95381847)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IPPK

Q9H8X2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-22414_311312534.3333333333335Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-22414_311301526.3333333333333Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-22314_31651382.0Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-22414_31652468.3333333333335Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-2514_3165184.0Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241_1001312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241_1001301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224101_1211312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224101_1211301526.3333333333333TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-22414_3102461.3333333333335Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-22414_3102513.3333333333335Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-22414_3102093.3333333333335Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224438_5981312534.3333333333335DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224438_5981301526.3333333333333DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224438_59802461.3333333333335DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224438_59802513.3333333333335DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224438_59802093.3333333333335DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223438_598651382.0DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224438_598652468.3333333333335DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25438_59865184.0DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241049_10551312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241077_10831312534.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241105_11211312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241142_11541312534.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241176_14471312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224122_4361312534.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224458_4721312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224494_5011312534.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224523_5471312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224569_5771312534.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224599_7481312534.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224770_10271312534.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241049_10551301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241077_10831301526.3333333333333Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241105_11211301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241142_11541301526.3333333333333Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241176_14471301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224122_4361301526.3333333333333Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224458_4721301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224494_5011301526.3333333333333Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224523_5471301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224569_5771301526.3333333333333Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224599_7481301526.3333333333333Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224770_10271301526.3333333333333Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241049_105502461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241077_108302461.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241105_112102461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241142_115402461.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241176_144702461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224122_43602461.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241_10002461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224458_47202461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224494_50102461.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224523_54702461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224569_57702461.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224599_74802461.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224770_102702461.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241049_105502513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241077_108302513.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241105_112102513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241142_115402513.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241176_144702513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224122_43602513.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241_10002513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224458_47202513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224494_50102513.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224523_54702513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224569_57702513.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224599_74802513.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224770_102702513.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241049_105502093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241077_108302093.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241105_112102093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241142_115402093.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241176_144702093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224122_43602093.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241_10002093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224458_47202093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224494_50102093.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224523_54702093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224569_57702093.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224599_74802093.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224770_102702093.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231049_1055651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231077_1083651382.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231105_1121651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231142_1154651382.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231176_1447651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223122_436651382.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231_100651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223458_472651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223494_501651382.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223523_547651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223569_577651382.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223599_748651382.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223770_1027651382.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241049_1055652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241077_1083652468.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241105_1121652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241142_1154652468.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241176_1447652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224122_436652468.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241_100652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224458_472652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224494_501652468.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224523_547652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224569_577652468.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224599_748652468.3333333333335Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224770_1027652468.3333333333335Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251049_105565184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251077_108365184.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251105_112165184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251142_115465184.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251176_144765184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25122_43665184.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251_10065184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25458_47265184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25494_50165184.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25523_54765184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25569_57765184.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25599_74865184.0Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25770_102765184.0Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241028_10481312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241056_10761312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241084_11041312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241122_11411312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241155_11751312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224437_4571312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224473_4931312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224502_5221312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224548_5681312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224578_5981312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224749_7691312534.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241028_10481301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241056_10761301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241084_11041301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241122_11411301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241155_11751301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224437_4571301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224473_4931301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224502_5221301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224548_5681301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224578_5981301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224749_7691301526.3333333333333TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224101_12102461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241028_104802461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241056_107602461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241084_110402461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241122_114102461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241155_117502461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224437_45702461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224473_49302461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224502_52202461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224548_56802461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224578_59802461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224749_76902461.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224101_12102513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241028_104802513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241056_107602513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241084_110402513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241122_114102513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241155_117502513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224437_45702513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224473_49302513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224502_52202513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224548_56802513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224578_59802513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224749_76902513.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224101_12102093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241028_104802093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241056_107602093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241084_110402093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241122_114102093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241155_117502093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224437_45702093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224473_49302093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224502_52202093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224548_56802093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224578_59802093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224749_76902093.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223101_121651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231028_1048651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231056_1076651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231084_1104651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231122_1141651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231155_1175651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223437_457651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223473_493651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223502_522651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223548_568651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223578_598651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223749_769651382.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224101_121652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241028_1048652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241056_1076652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241084_1104652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241122_1141652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241155_1175652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224437_457652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224473_493652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224502_522652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224548_568652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224578_598652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224749_769652468.3333333333335TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25101_12165184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251028_104865184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251056_107665184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251084_110465184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251122_114165184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251155_117565184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25437_45765184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25473_49365184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25502_52265184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25548_56865184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25578_59865184.0TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25749_76965184.0TransmembraneHelical
TgeneIPPKchr9:98268689chr9:95381847ENST000002879961013136_140390492.0MotifNote=EXKPK motif


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Fusion Gene Sequence for PTCH1-IPPK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69866_69866_1_PTCH1-IPPK_PTCH1_chr9_98268689_ENST00000331920_IPPK_chr9_95381847_ENST00000287996_length(transcript)=3648nt_BP=694nt
GAACTGGATGTGGGCAGCGGCGGCCGCAGAGACCTCGGGACCCCCGCGCAATGTGGCAATGGAAGGCGCAGGGTCTGACTCCCCGGCAGC
GGCCGCGGCCGCAGCGGCAGCAGCGCCCGCCGTGTGAGCAGCAGCAGCGGCTGGTCTGTCAACCGGAGCCCGAGCCCGAGCAGCCTGCGG
CCAGCAGCGTCCTCGCAAGCCGAGCGCCCAGGCGCGCCAGGAGCCCGCAGCAGCGGCAGCAGCGCGCCGGGCCGCCCGGGAAGCCTCCGT
CCCCGCGGCGGCGGCGGCGGCGGCGGCAACATGGCCTCGGCTGGTAACGCCGCCGAGCCCCAGGACCGCGGCGGCGGCGGCAGCGGCTGT
ATCGGTGCCCCGGGACGGCCGGCTGGAGGCGGGAGGCGCAGACGGACGGGGGGGCTGCGCCGTGCTGCCGCGCCGGACCGGGACTATCTG
CACCGGCCCAGCTACTGCGACGCCGCCTTCGCTCTGGAGCAGATTTCCAAGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGA
GCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGG
GCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGAC
TGCCAAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTC
CAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGT
CAACTATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAAAGCGAAGATTGCACATTAGTTCTCCA
CAAGGTCTAACTCTTTCCCTGCAGTGTCTTTGAAACTTGAACATAATGTGAAGGCTGAATGATAGAGATATTTTCTGTTGTGTTGGGTGA
CCTTTGGTTGTGAATGTTTTTGCTTTTAACCCCTTTTGAGGTGGGATTGCCTCTTGGAGACATGGAATTGAAGAGCACTAGAAACAACTT
CCTGGACAAGGAATGTAGGAAGTGAGTGCTGTGTCCCAGGAAGCTGCTCACACTCTTAAAATGGAAGTGTCCGTTAAGCCCTGGGAAGAC
GTTCTGGATAGTTCTTCTTTCCCAACCAGGGCTCATGTCTGATTCTCTAATGCGAAAAGCCTTATTCTAAGACCCAAGGTTTGGATCTGC
TACCACCAGACTCCTAACATAGAAAACTTGAATTGTCACATACATTTTACAGTTTGGACTTTTAAGAAAACATGGATACTACTGGAACTT
CCCCCAGCTGAGTTACATGGTCACTTTTTCAGTGCAAGCCACATATCAACACAGGTTTTTAGGTGGTTCCCTGCTGCACAGCGTGACCTC
GTGGTCGCGCAGATGCCGATTCTGAGCAGTGTAGACTCAGGGTCCCTGTGGAGGTGCTGAAGCCCACAGTTCCACACAGGGCAGCAGGGA
GCGCAAGGCTCAGGTCAGGATGGACACCACTCATGCGAGCATTGACCTTTTTTTTTTTGCTTTACAATTTAATCTTTCACATGAGGGGGA
GATGAGCTGTTCTTTCCCACTAAAAATTGCTGCTGTAGAAGTTGGAGGTGGAGCTGTGACTGGCTGAGCTGCTGTGGCCGGGCTGGGCAG
TGTGCCCCAACAGCTCAGTGCTTTCCTGACACTCCAGTGTCTGGGGTGGTTGAGGAGCGAGTTCTCTCTTCCTCCCAGACCAAGTTCCTC
CCTCGGGTTTGCCTTGAGACGTGTTGCGTTTTTGGGCCCCGTGGCCTCTCCCTGTTAGGCTGCCACAGGCCCTGCTTCTGGAAGGTGAAC
AGCTCCTGGCTGCTGCCGAGAGGGTTCTCGTTGGGGTCACCAAAGTGTGCCCGGCTGCTATGAAAAACGTTGGGAATCTTGGTTTCAGTT
TTTTATTCTATGCTAGGTTGTACAGACTTATTTATATCATCGTTTTGAGGGACTAATGGAGGCTTATTGTAACATATAATATTAGTGAAA
CCATGGAATTATATGAAAATGATACATGAGAAATAAGGAAACTATTTTGCTGATTGTAAATTTTTGTGGGAAATTTTGTGATAACTTGAG
AATTATACTTGTTTGAATCAAGGCAACTCTTCTAGAATTTATTGTTCAATTCTGTCATATTTACTTCTAATTCTACTCTCAGAGGTGCAA
AAAGATACTTATCTAACTGGACACTTTTACTGTTTTCTTCTCACTTCCAATGACACCGTCTCATACACACGGGTCCTGTGTGCTGGGATG
GGGGCTTTGGTGAAGTGCACGGAGCTCACGGACAAGCCGCAGGCTCTGGGAAGCGTGGAGGTAGTGGCCGTTGAGTACTGTCTTGACCCA
AGGGAGTTCACTGTTGCTGGGCTGGGGCTGGGGCAGCCTGGTTTGGGATGATTTTGCCCATTGTCACGGTGTGTGGAGGATGCTGGGTCC
TGGGTTCAAGTGCACATGTGAGGGAACCCCAGTCCGTGGGAAGGTGGGCTGGGCTCCCTAGGTCCTTCAGGGCTGCAAGAGTTATTGCCT
AGCACAGGGCCCAGACAGGGCTGGACTAGACACGATGAAAACAGCCTGTATTTGAGGGAGAAGAGAAAACAGATGGAGACCCCCACTCTG
TCTGGTCTTGGCTCCCACCAGCCCGGGCTGTGAGGAGCCCCTGAGCCGCGGGTGCCACTGCTGTGGATGCGTTTCTGGCCCGTCTTGGAA
ACTGCTGCTGCTGCGTAGTCATGACGGCCCTGACTGGTTTGAGACAACACGCGTTCACAGATCTTAACAATGCTAAATGGGCGACTGATG
AGGTCACGGTTCTTAAGGCACATCCGGGACGATCGATATAGCACTTAGGCTATGCAGGGGGGTCTTTCTTTCATAAAGGACCTCATTCCT
TGCGTCCCAGCCCAGGAACAGTGCTGTCTTTGCTGTCTTAGGCCATTCTTGTTATTAAGCTGACAGCTTCACTTTCTTGTGGAAGACCAA
GAACAGCATGAGGACTTGCTGAGACTGCCTCACGGTGCCACCATGCGGACCGGGGGGAGGCAGGGAGTGAGGGTGTGGCTCCCCTGGGCT
ACTAAGGACAGTTTAAAGATGAGGCGCCATAGGCATCCGTCTCCAGAGCCCCCAGGAGGCAGGAACCAGGATAAGGGTGGCTTCTCCCAG
CTGAGTAATGTGGCCACCATGTCCAAGGTGGACTCGGTGTGAGGCTGCAGTGGGTGGGGGATGGATCCTCCCCACACATCTGAGGACACA
CAACCACTTGGTACATTTTCTCAGATGTTAAGCTTATTTTTATAAACCACATTGTACGTGTCACTTTTATTTGGCATTTTATACTTAACT
AGTTGTATTTATTTTTCATGTCATGAGAGTTTCCATATAATGTGCCATAACTGCATAGACAGCACGTCTTCAGGGTGTGGTTTCTAAGCA

>69866_69866_1_PTCH1-IPPK_PTCH1_chr9_98268689_ENST00000331920_IPPK_chr9_95381847_ENST00000287996_length(amino acids)=201AA_BP=173
MRPAASSQAERPGAPGARSSGSSAPGRPGSLRPRGGGGGGGNMASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRD
YLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEGAAVPRR

--------------------------------------------------------------
>69866_69866_2_PTCH1-IPPK_PTCH1_chr9_98268689_ENST00000375274_IPPK_chr9_95381847_ENST00000287996_length(transcript)=3490nt_BP=536nt
ACCCAGGAGGGCTGTGCTGATAGCACGTTCCTCGAGTTTACTTTGCTTTCCTTGAGTTTATTGTAAAGGGGTAAAGTTTTCGGATCCGTC
ACGTGACCCTGACAGGTCCTGCCTATGGCGCGGCAGACCACCCACGCCGAGGGCCATGGAACTGCTTAATAGAAACAGGCTTGTAATTGT
GAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTTTACACTTTCCGTTCCTTTTGTAAAGACGGAGGAGG
AGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAAGAGACCCGCAGCGACAAGGGGAAGGCTACTGGCCG
GAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGT
TGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGC
AGCAGTACCGCGTCGCCATGACTGCCAAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGC
CTGTCGTCCCTTCATCGAGGTCCAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGT
ATAAACTGGACGGCAAGATCGTCAACTATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAAAGCG
AAGATTGCACATTAGTTCTCCACAAGGTCTAACTCTTTCCCTGCAGTGTCTTTGAAACTTGAACATAATGTGAAGGCTGAATGATAGAGA
TATTTTCTGTTGTGTTGGGTGACCTTTGGTTGTGAATGTTTTTGCTTTTAACCCCTTTTGAGGTGGGATTGCCTCTTGGAGACATGGAAT
TGAAGAGCACTAGAAACAACTTCCTGGACAAGGAATGTAGGAAGTGAGTGCTGTGTCCCAGGAAGCTGCTCACACTCTTAAAATGGAAGT
GTCCGTTAAGCCCTGGGAAGACGTTCTGGATAGTTCTTCTTTCCCAACCAGGGCTCATGTCTGATTCTCTAATGCGAAAAGCCTTATTCT
AAGACCCAAGGTTTGGATCTGCTACCACCAGACTCCTAACATAGAAAACTTGAATTGTCACATACATTTTACAGTTTGGACTTTTAAGAA
AACATGGATACTACTGGAACTTCCCCCAGCTGAGTTACATGGTCACTTTTTCAGTGCAAGCCACATATCAACACAGGTTTTTAGGTGGTT
CCCTGCTGCACAGCGTGACCTCGTGGTCGCGCAGATGCCGATTCTGAGCAGTGTAGACTCAGGGTCCCTGTGGAGGTGCTGAAGCCCACA
GTTCCACACAGGGCAGCAGGGAGCGCAAGGCTCAGGTCAGGATGGACACCACTCATGCGAGCATTGACCTTTTTTTTTTTGCTTTACAAT
TTAATCTTTCACATGAGGGGGAGATGAGCTGTTCTTTCCCACTAAAAATTGCTGCTGTAGAAGTTGGAGGTGGAGCTGTGACTGGCTGAG
CTGCTGTGGCCGGGCTGGGCAGTGTGCCCCAACAGCTCAGTGCTTTCCTGACACTCCAGTGTCTGGGGTGGTTGAGGAGCGAGTTCTCTC
TTCCTCCCAGACCAAGTTCCTCCCTCGGGTTTGCCTTGAGACGTGTTGCGTTTTTGGGCCCCGTGGCCTCTCCCTGTTAGGCTGCCACAG
GCCCTGCTTCTGGAAGGTGAACAGCTCCTGGCTGCTGCCGAGAGGGTTCTCGTTGGGGTCACCAAAGTGTGCCCGGCTGCTATGAAAAAC
GTTGGGAATCTTGGTTTCAGTTTTTTATTCTATGCTAGGTTGTACAGACTTATTTATATCATCGTTTTGAGGGACTAATGGAGGCTTATT
GTAACATATAATATTAGTGAAACCATGGAATTATATGAAAATGATACATGAGAAATAAGGAAACTATTTTGCTGATTGTAAATTTTTGTG
GGAAATTTTGTGATAACTTGAGAATTATACTTGTTTGAATCAAGGCAACTCTTCTAGAATTTATTGTTCAATTCTGTCATATTTACTTCT
AATTCTACTCTCAGAGGTGCAAAAAGATACTTATCTAACTGGACACTTTTACTGTTTTCTTCTCACTTCCAATGACACCGTCTCATACAC
ACGGGTCCTGTGTGCTGGGATGGGGGCTTTGGTGAAGTGCACGGAGCTCACGGACAAGCCGCAGGCTCTGGGAAGCGTGGAGGTAGTGGC
CGTTGAGTACTGTCTTGACCCAAGGGAGTTCACTGTTGCTGGGCTGGGGCTGGGGCAGCCTGGTTTGGGATGATTTTGCCCATTGTCACG
GTGTGTGGAGGATGCTGGGTCCTGGGTTCAAGTGCACATGTGAGGGAACCCCAGTCCGTGGGAAGGTGGGCTGGGCTCCCTAGGTCCTTC
AGGGCTGCAAGAGTTATTGCCTAGCACAGGGCCCAGACAGGGCTGGACTAGACACGATGAAAACAGCCTGTATTTGAGGGAGAAGAGAAA
ACAGATGGAGACCCCCACTCTGTCTGGTCTTGGCTCCCACCAGCCCGGGCTGTGAGGAGCCCCTGAGCCGCGGGTGCCACTGCTGTGGAT
GCGTTTCTGGCCCGTCTTGGAAACTGCTGCTGCTGCGTAGTCATGACGGCCCTGACTGGTTTGAGACAACACGCGTTCACAGATCTTAAC
AATGCTAAATGGGCGACTGATGAGGTCACGGTTCTTAAGGCACATCCGGGACGATCGATATAGCACTTAGGCTATGCAGGGGGGTCTTTC
TTTCATAAAGGACCTCATTCCTTGCGTCCCAGCCCAGGAACAGTGCTGTCTTTGCTGTCTTAGGCCATTCTTGTTATTAAGCTGACAGCT
TCACTTTCTTGTGGAAGACCAAGAACAGCATGAGGACTTGCTGAGACTGCCTCACGGTGCCACCATGCGGACCGGGGGGAGGCAGGGAGT
GAGGGTGTGGCTCCCCTGGGCTACTAAGGACAGTTTAAAGATGAGGCGCCATAGGCATCCGTCTCCAGAGCCCCCAGGAGGCAGGAACCA
GGATAAGGGTGGCTTCTCCCAGCTGAGTAATGTGGCCACCATGTCCAAGGTGGACTCGGTGTGAGGCTGCAGTGGGTGGGGGATGGATCC
TCCCCACACATCTGAGGACACACAACCACTTGGTACATTTTCTCAGATGTTAAGCTTATTTTTATAAACCACATTGTACGTGTCACTTTT
ATTTGGCATTTTATACTTAACTAGTTGTATTTATTTTTCATGTCATGAGAGTTTCCATATAATGTGCCATAACTGCATAGACAGCACGTC

>69866_69866_2_PTCH1-IPPK_PTCH1_chr9_98268689_ENST00000375274_IPPK_chr9_95381847_ENST00000287996_length(amino acids)=158AA_BP=130
MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDKETRSDKGKATGRKAPLWLRAKFQRLLFKLG

--------------------------------------------------------------
>69866_69866_3_PTCH1-IPPK_PTCH1_chr9_98268689_ENST00000437951_IPPK_chr9_95381847_ENST00000287996_length(transcript)=3644nt_BP=690nt
ACCCAGGAGGGCTGTGCTGATAGCACGTTCCTCGAGTTTACTTTGCTTTCCTTGAGTTTATTGTAAAGGGGTAAAGTTTTCGGATCCGTC
ACGTGACCCTGACAGGTCCTGCCTATGGCGCGGCAGACCACCCACGCCGAGGGCCATGGAACTGCTTAATAGAAACAGGCTTGTAATTGT
GAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTTTACACTTTCCGTTCCTTTTGTAAAGACGGAGGAGG
AGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAAGAGACCCGCAGCGACAAGGCAAGGGGGAGACGAGG
GAAGACTGGGAGAAGACGGAGGAGCGGAGGACGAGGAAAGGGGGGCCAGGGAAAAAAAAGGAATTGATGTGAAATCCAAGCCCAGCGTCC
GCGCCATCGGCACCCGCGCTCCGAGCAGGGGTTGACGGCCGGCTATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGA
AGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCT
TCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGACTGCC
AAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTCCAGG
TTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGTCAAC
TATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAAAGCGAAGATTGCACATTAGTTCTCCACAAG
GTCTAACTCTTTCCCTGCAGTGTCTTTGAAACTTGAACATAATGTGAAGGCTGAATGATAGAGATATTTTCTGTTGTGTTGGGTGACCTT
TGGTTGTGAATGTTTTTGCTTTTAACCCCTTTTGAGGTGGGATTGCCTCTTGGAGACATGGAATTGAAGAGCACTAGAAACAACTTCCTG
GACAAGGAATGTAGGAAGTGAGTGCTGTGTCCCAGGAAGCTGCTCACACTCTTAAAATGGAAGTGTCCGTTAAGCCCTGGGAAGACGTTC
TGGATAGTTCTTCTTTCCCAACCAGGGCTCATGTCTGATTCTCTAATGCGAAAAGCCTTATTCTAAGACCCAAGGTTTGGATCTGCTACC
ACCAGACTCCTAACATAGAAAACTTGAATTGTCACATACATTTTACAGTTTGGACTTTTAAGAAAACATGGATACTACTGGAACTTCCCC
CAGCTGAGTTACATGGTCACTTTTTCAGTGCAAGCCACATATCAACACAGGTTTTTAGGTGGTTCCCTGCTGCACAGCGTGACCTCGTGG
TCGCGCAGATGCCGATTCTGAGCAGTGTAGACTCAGGGTCCCTGTGGAGGTGCTGAAGCCCACAGTTCCACACAGGGCAGCAGGGAGCGC
AAGGCTCAGGTCAGGATGGACACCACTCATGCGAGCATTGACCTTTTTTTTTTTGCTTTACAATTTAATCTTTCACATGAGGGGGAGATG
AGCTGTTCTTTCCCACTAAAAATTGCTGCTGTAGAAGTTGGAGGTGGAGCTGTGACTGGCTGAGCTGCTGTGGCCGGGCTGGGCAGTGTG
CCCCAACAGCTCAGTGCTTTCCTGACACTCCAGTGTCTGGGGTGGTTGAGGAGCGAGTTCTCTCTTCCTCCCAGACCAAGTTCCTCCCTC
GGGTTTGCCTTGAGACGTGTTGCGTTTTTGGGCCCCGTGGCCTCTCCCTGTTAGGCTGCCACAGGCCCTGCTTCTGGAAGGTGAACAGCT
CCTGGCTGCTGCCGAGAGGGTTCTCGTTGGGGTCACCAAAGTGTGCCCGGCTGCTATGAAAAACGTTGGGAATCTTGGTTTCAGTTTTTT
ATTCTATGCTAGGTTGTACAGACTTATTTATATCATCGTTTTGAGGGACTAATGGAGGCTTATTGTAACATATAATATTAGTGAAACCAT
GGAATTATATGAAAATGATACATGAGAAATAAGGAAACTATTTTGCTGATTGTAAATTTTTGTGGGAAATTTTGTGATAACTTGAGAATT
ATACTTGTTTGAATCAAGGCAACTCTTCTAGAATTTATTGTTCAATTCTGTCATATTTACTTCTAATTCTACTCTCAGAGGTGCAAAAAG
ATACTTATCTAACTGGACACTTTTACTGTTTTCTTCTCACTTCCAATGACACCGTCTCATACACACGGGTCCTGTGTGCTGGGATGGGGG
CTTTGGTGAAGTGCACGGAGCTCACGGACAAGCCGCAGGCTCTGGGAAGCGTGGAGGTAGTGGCCGTTGAGTACTGTCTTGACCCAAGGG
AGTTCACTGTTGCTGGGCTGGGGCTGGGGCAGCCTGGTTTGGGATGATTTTGCCCATTGTCACGGTGTGTGGAGGATGCTGGGTCCTGGG
TTCAAGTGCACATGTGAGGGAACCCCAGTCCGTGGGAAGGTGGGCTGGGCTCCCTAGGTCCTTCAGGGCTGCAAGAGTTATTGCCTAGCA
CAGGGCCCAGACAGGGCTGGACTAGACACGATGAAAACAGCCTGTATTTGAGGGAGAAGAGAAAACAGATGGAGACCCCCACTCTGTCTG
GTCTTGGCTCCCACCAGCCCGGGCTGTGAGGAGCCCCTGAGCCGCGGGTGCCACTGCTGTGGATGCGTTTCTGGCCCGTCTTGGAAACTG
CTGCTGCTGCGTAGTCATGACGGCCCTGACTGGTTTGAGACAACACGCGTTCACAGATCTTAACAATGCTAAATGGGCGACTGATGAGGT
CACGGTTCTTAAGGCACATCCGGGACGATCGATATAGCACTTAGGCTATGCAGGGGGGTCTTTCTTTCATAAAGGACCTCATTCCTTGCG
TCCCAGCCCAGGAACAGTGCTGTCTTTGCTGTCTTAGGCCATTCTTGTTATTAAGCTGACAGCTTCACTTTCTTGTGGAAGACCAAGAAC
AGCATGAGGACTTGCTGAGACTGCCTCACGGTGCCACCATGCGGACCGGGGGGAGGCAGGGAGTGAGGGTGTGGCTCCCCTGGGCTACTA
AGGACAGTTTAAAGATGAGGCGCCATAGGCATCCGTCTCCAGAGCCCCCAGGAGGCAGGAACCAGGATAAGGGTGGCTTCTCCCAGCTGA
GTAATGTGGCCACCATGTCCAAGGTGGACTCGGTGTGAGGCTGCAGTGGGTGGGGGATGGATCCTCCCCACACATCTGAGGACACACAAC
CACTTGGTACATTTTCTCAGATGTTAAGCTTATTTTTATAAACCACATTGTACGTGTCACTTTTATTTGGCATTTTATACTTAACTAGTT
GTATTTATTTTTCATGTCATGAGAGTTTCCATATAATGTGCCATAACTGCATAGACAGCACGTCTTCAGGGTGTGGTTTCTAAGCAGAAA

>69866_69866_3_PTCH1-IPPK_PTCH1_chr9_98268689_ENST00000437951_IPPK_chr9_95381847_ENST00000287996_length(amino acids)=130AA_BP=
MKLRSQPQRRFPASSLPHSRPSTPARSAGADGADAGLGFHINSFFFPGPPFLVLRSSVFSQSSLVSPLPCRCGSLCLPCRLFLLLRFLLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTCH1-IPPK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTCH1-IPPK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTCH1-IPPK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource