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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PTDSS1-NIPAL2 (FusionGDB2 ID:69889)

Fusion Gene Summary for PTDSS1-NIPAL2

Fusion gene summary

Fusion gene information	Fusion gene name: PTDSS1-NIPAL2
	Fusion gene ID: 69889
		Hgene	Tgene
	Gene symbol	PTDSS1	NIPAL2
	Gene ID	9791	79815
	Gene name	phosphatidylserine synthase 1	NIPA like domain containing 2
	Synonyms	LMHD\|PSS1\|PSSA	NPAL2
	Cytomap	8q22.1	8q22.2
	Type of gene	protein-coding	protein-coding
	Description	phosphatidylserine synthase 1PSS-1ptdSer synthase 1serine-exchange enzyme I	NIPA-like protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H841
	Ensembl transtripts involved in fusion gene	ENST00000518776, ENST00000517309, ENST00000455950, ENST00000522072,	ENST00000341166, ENST00000430223, ENST00000520545,
Fusion gene scores	* DoF score	5 X 5 X 4=100	8 X 7 X 8=448
	# samples	5	11
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/448*10)=-2.02599520853294 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTDSS1 [Title/Abstract] AND NIPAL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PTDSS1(97299374)-NIPAL2(99266315), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PTDSS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NIPAL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-BT-A2LD-01A	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-

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Fusion Gene ORF analysis for PTDSS1-NIPAL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000518776	ENST00000341166	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
3UTR-3CDS	ENST00000518776	ENST00000430223	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
3UTR-intron	ENST00000518776	ENST00000520545	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
5CDS-intron	ENST00000517309	ENST00000520545	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
In-frame	ENST00000517309	ENST00000341166	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
In-frame	ENST00000517309	ENST00000430223	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
intron-3CDS	ENST00000455950	ENST00000341166	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
intron-3CDS	ENST00000455950	ENST00000430223	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
intron-3CDS	ENST00000522072	ENST00000341166	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
intron-3CDS	ENST00000522072	ENST00000430223	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
intron-intron	ENST00000455950	ENST00000520545	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-
intron-intron	ENST00000522072	ENST00000520545	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000517309

PTDSS1

chr8

97299374

ENST00000430223

NIPAL2

chr8

99266315

4929

767

179

1783

534

ENST00000517309

PTDSS1

chr8

97299374

ENST00000341166

NIPAL2

chr8

99266315

4957

767

179

1738

519

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000517309	ENST00000430223	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-	0.001033806	0.9989662
ENST00000517309	ENST00000341166	PTDSS1	chr8	97299374	+	NIPAL2	chr8	99266315	-	0.001330806	0.99866927

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Fusion Genomic Features for PTDSS1-NIPAL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTDSS1-NIPAL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:97299374/chr8:99266315)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NIPAL2 Q9H841
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

2_35

147

474.0

Topological domain

Cytoplasmic

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

57_72

147

474.0

Topological domain

Lumenal

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

94_102

147

474.0

Topological domain

Cytoplasmic

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

103_123

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

36_56

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

73_93

147

474.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

110_130

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

144_164

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

177_197

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

209_229

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

243_263

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

278_298

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

306_326

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

46_66

369.0

Transmembrane

Helical

Tgene

NIPAL2

chr8:97299374

chr8:99266315

ENST00000341166

88_108

369.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

124_186

147

474.0

Topological domain

Lumenal

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

208_216

147

474.0

Topological domain

Cytoplasmic

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

238_286

147

474.0

Topological domain

Lumenal

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

308_319

147

474.0

Topological domain

Cytoplasmic

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

343_355

147

474.0

Topological domain

Lumenal

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

377_383

147

474.0

Topological domain

Cytoplasmic

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

405_473

147

474.0

Topological domain

Lumenal

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

187_207

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

217_237

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

287_307

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

320_342

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

356_376

147

474.0

Transmembrane

Helical

Hgene

PTDSS1

chr8:97299374

chr8:99266315

ENST00000517309

384_404

147

474.0

Transmembrane

Helical

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Fusion Gene Sequence for PTDSS1-NIPAL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>69889_69889_1_PTDSS1-NIPAL2_PTDSS1_chr8_97299374_ENST00000517309_NIPAL2_chr8_99266315_ENST00000341166_length(transcript)=4957nt_BP=767nt
AGCCAGGGGCCCCGGCTACCCTTCTCCGGCTCGCTATTCCTCTGAAGTCCTGTGGACTTGGAGTCTGAAAATTCCTCGAGTGGTAGAGAT
GCCTCAGCTAGGATGACAGCGTGGGGACGGCCGGCGGCGTCCCCTGCCCCAGGCCGCGGTGGCGGCGCCGCGACCCCGCCCTCTCGCGCC
TGTCCTTCCCTCTGCTCCCAGCCTTTGCTGGGCGCCAGACCCGGCTTTGCCGTCCGGCTATTAGCCTACTGTGGCTAGTCACCCCCGGGG
TCCCGGCCTTCTCGGGCTGGGGCCGCCGCCACCGCGGCAGGACGGGGAGGCGGGCCATGGCGTCCTGCGTGGGGAGCCGGACCCTAAGCA
AGGATGATGTGAACTACAAAATGCATTTCCGGATGATCAACGAGCAGCAAGTGGAGGACATCACCATTGACTTCTTCTACCGGCCGCATA
CCATCACCCTGCTCAGCTTCACCATCGTCAGCCTCATGTACTTCGCCTTTACCAGGGATGACTCTGTTCCAGAAGACAACATCTGGAGAG
GCATCCTCTCTGTTATTTTCTTCTTTCTTATCATCAGTGTGTTAGCTTTCCCCAATGGTCCGTTCACTCGACCTCATCCAGCCTTATGGC
GAATGGTTTTTGGACTCAGTGTGCTCTACTTCCTGTTCCTGGTATTCCTACTCTTCCTGAATTTCGAGCAGGTTAAATCTCTAATGTATT
GGCTAGATCCAAATCTTCGATACGCCACAAGGGAAGCAGATGTCATGATTCACCTTTTTGGAGTTTTGCTGGCTATTTTAGGAAACTTGG
TGATCAGTATTTCTCTAAATATTCAGAAATATTCTCACCTTCAGCTGGCACAACAAGAGCACCCAAGGCCATACTTCAAGAGTGTGCTGT
GGTGGGGTGGTGTCCTGCTGATGGCCGTGGGAGAGACGGGGAACTTTGCAGCCTATGGATTTGCTCCCATTACTCTGATCGCTCCGTTAG
GCTGTGTGTCTGTTACAGGTAGTGCCATTATTTCTGTTACATTTCTGAAAGACAATTTGAGAGCCTCAGACTTACTCGGTACGACACTGG
CATTTGCAGGAACATATTTACTGGTGAACTTTGCTCCAAATATAACTCAGGCAATCTCAGCAAGAACAGTACAGTATTACCTTGTCGGAT
GGCAGTTCCTGATCTATGTGATTTTAGAAATATTAATTTTCTGCATTCTCCTGTATTTCTATAAAAGAAAAGGAATGAAGCATATGGTGA
TTCTGCTAACCCTGGTGGCAATTCTAGCCTCATTGACTGTTATTTCAGTAAAGGCCGTCTCAGGCATGATCACTTTTTCTGTGATGGATA
AAATGCAACTAACTTACCCCATTTTCTATATCATGTTTATCATCATGATAGCATCTTGTGTTTTCCAAGTCAAGTTCCTGAATCAAGCCA
CGAAACTCTACAATACGACAACAGTGGTGCCAGTTAATCATATTTTCTTTACAATCAGTGCCATCATTGCAGGTATCATATTTTATCAGG
AATTCCTTGGTGCTCCTTTTCTCACTGTATTTATATATCTTTTTGGGTGTTTTCTGTCATTCCTTGGTGTATTTTTGGTCACAAGAAATC
GAGAAAAGGAACATCTGCAACAGTCTTATATTGATTTTGGAAATATTCCTGACACAACCCCAGAGAGAAAGGCTTGGAGGGAAACAAATG
TTGGACAAAATACAACCAGATTCACATAGCTTATCCTATGGAACTTTGCCTGATGGAAGTGACTCAACAAAGAGCCAAAGTGGAGAGAAG
AAAGAGGTCTAAATGCTGAGAAGGATGGCTGTTGGCCTGTTATTCGATACCACCTTTTTAAAAAATTGCACATGTTCAATTTGTGTCAGC
AGCTCTTTTATAAGCTAACATGTGCTAGCATTCATTTCAGTCCTTTCCCCCACCTCAGCGTCTATGGACAATCGGGGACTTCCTAAGCTC
TGACAGTCTAATATTTCCATGGAATGTGATTTGGAGTGTTCCCCACACCCTGGACCTCTCCCTAGTGATTATCTAGCCAGCTACACCTTA
CTCAGAGCCCGGCTGCTCTAGCAGGAATGTTGCACAGAAACATACATTTGCGGTTTGGCCACAGGTCGCATAGGTGGCTTCTCCCACGGG
TAGTGTCAGTTGCTTCACTTTAAAAAGTCACTTCAGCCCCACAACCTCACTCCCAAAAGAAAGGTTTGAGAGCGCTCATTTTTTTTCTAA
GACACCTTTTATAAGCCTCCCTATAAAAATCTCACCTTTCAAGTACTAAGTTAGAATTGCAAGTCATCTTTTCTGAAAACTAATGCTATC
AAAGTCCTCCTTTGAAAATTAAGGGTCTCTTTAAAATTAGAATTTATAAATGGCATTCAGTGATAGTGTACACCAAAATTAAAAGACCTT
GACTGGTGGGCTTTTTACGTGTAAGGAAGAGGAAGTTTAAGAAGTAGGACTCTGCTTGTTTCAGTAGCCCATGTACTAAAATAGGAACAA
TGCAGAGATTAGCACAGCCCCTGCACAAGGCTGACACATAAATTCATGAAGCGTTAGAGACAAAAAGTAGGACTAATGTTTGTTTATTTT
TTAATAAAAATCTAGAATGGTGATGTTTTCTTCAGCTGTATGATTCTATCATACTTGAAACTGAAGAAAAATTTAATATCCTATGTCTTT
TTTATAGATCTTATAATTTATCAAGTGGATTTATATGTCTTATTCTCCATATAAGTCTAAAAAATCACATTTAAATTCTTAGTGATAGTT
TCACTACACATCATTTCTTCCCAAAGTCATTACCTCAAGCTTTGTAAATTCTTCTAGATAAAAGGAGAGTTGTGATTAGAGAACTGAATT
TCAGCCATTTAAACCTGTAGACATAGAAAACAACCCAGTGGTCAAACCTGAGCTTCAAGAGGAAGCCCAAGTCCTCCTGTTTCCTGAATG
GCTTTTCCACTCCAATTCATCACATATCTGCTAAGACACATTTGCAGGTAGAATCCATAATAATATCTGTTATTTATGATCTACCTAATA
TTTAAAGGAGAAGAAAAGAAGTAGCCTTCGTTGCAGCCAACATCCAACAATAAGTCCCACCCTTAATGACATTTCAAAGCCTTCAGATCA
CTTCTGACATGTCTGTCCAATATCATTCCAATCAATAGTCTTGCATTTAAATAGGTTGTTTAACTCGGTGGTATTGAGACTGTAACCTTA
ATGGCTCAGGTCTTTTAGCTTTGTTCTTTGTCATAATCTGCACTCCTGGCCAGACTGACCAAACCTGGCTGCAAAGGAAAGAGATTTGAA
TTGATCACCAATGTATGAAAAATACAGAACCCATGTCTGGCTCCTAAACTCCTGGTAATAATTCCCGCCATCGTAGCAAGTGTCCCATGC
ATTCAGATAAAGCAGTCATAATTTATGGTGTATTTTACCGAATTGGTCCAGCATATTGGTCCTACAAGGCTCAGCCAAGAAATGTATCTG
GTGCCTTAAACTACAGATTTCTGGTGACTCTTAAAACTGGTTTACAAAGATTGAGAAAACAATTAGATTGAAGAGTTTTGCTTCAAGTAG
ACCTGCATTCATAGCTAGAGTGCATGAGATTTTCAGCACTGTAGAATTTCACACAGGCACAAGCATAACACCAGTACTTTAGCAGCCGCC
AACAGTTGCATCTATTAAACGTTTTGAGAAATGACATTGACTTATGCACATTTAAGCAATCAACAATGTTTTAGAAGTCCAGGTAACATA
TAAAATATATTCAGACCTAGTTTTACTTTCCATATTGTTGCTCCAAAGTAAGGTAAATAGGAGTTTTAGTTGTACTGGCCTGTAAGATTT
TTTAAATTACACAGTGCATGACAACAACTAAAGCCAACTCAGTCCTTCTCTTGGCATTGTGAGTTGAGGACCTTTAGCCAACTGTTAGCT
CATCTGACTATCTGTCTAGACCAAGGGTCGGCAAAGTTTTCAGTAAAGACCCACAGAGTACATATTTTGGAGTTTGTGTTGTCTGTACCA
ACAGACAGACATGGTGTCTGTCCCAACTACCCAACTCTGCCATTGTAGCACTAAAGCAGCCATAGACAAGATGTAAACAGAAGAGCATGG
CTGTGTTCCAGTAAAACTTTATTTACAGGCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCTGACAGATCA
TCTGAGGTTAGGAGTTTGGGACCAGCCTGGTCAACATAGTGAAACCCCATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGACGGTGG
GTGCCTGGAGTCCCAGCTACCTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCA
TTGCACTCCAGCCTGGGCGACAGAGTAAGACTGTCTCAAAAACAAACAAACAAACAAACAAACAAAAACAAGTGGCCAGTCTGTGAGCTA
TAGTTCCCAACACCTGGTCTAGACTCTTCTGCCCTTGCTCTGCAGCTTCTTTCCTGTTGATTGGGCATTCAGGGAAGGAGTTTAAAAAGT
GACACTCATGGCTCATGACAAATGAGATACTTTGGGAGTGTGGAAACATGGCTTGATATTTGCCTTCAGATATTTTTGCTTATATAAGTT
CTAAATGGAAGTGATAAGTTCATTCTTAGGGTCCAAGTTGAAAGGCAGTGGTTCTTTTGTGAACACCACTAACTACATTCGAAAAGCCTC
TCCAATTCCACATTCCAAGTCTATAACAGCTTTGGAAATGAGTAACAATGACCTCTCATGTAGTAGATTAAAGCAGAGGCCTTTGCCATA
TGATTGTTTTTTGGCTTAAATGTTTGCTTGCCCTGTAACTGTAATACTTTGGTTACCAGAATCACTTGAAAACAAATACAATAAAAAAAT

>69889_69889_1_PTDSS1-NIPAL2_PTDSS1_chr8_97299374_ENST00000517309_NIPAL2_chr8_99266315_ENST00000341166_length(amino acids)=519AA_BP=196
MSFPLLPAFAGRQTRLCRPAISLLWLVTPGVPAFSGWGRRHRGRTGRRAMASCVGSRTLSKDDVNYKMHFRMINEQQVEDITIDFFYRPH
TITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMY
WLDPNLRYATREADVMIHLFGVLLAILGNLVISISLNIQKYSHLQLAQQEHPRPYFKSVLWWGGVLLMAVGETGNFAAYGFAPITLIAPL
GCVSVTGSAIISVTFLKDNLRASDLLGTTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQFLIYVILEILIFCILLYFYKRKGMKHMV
ILLTLVAILASLTVISVKAVSGMITFSVMDKMQLTYPIFYIMFIIMIASCVFQVKFLNQATKLYNTTTVVPVNHIFFTISAIIAGIIFYQ

--------------------------------------------------------------
>69889_69889_2_PTDSS1-NIPAL2_PTDSS1_chr8_97299374_ENST00000517309_NIPAL2_chr8_99266315_ENST00000430223_length(transcript)=4929nt_BP=767nt
AGCCAGGGGCCCCGGCTACCCTTCTCCGGCTCGCTATTCCTCTGAAGTCCTGTGGACTTGGAGTCTGAAAATTCCTCGAGTGGTAGAGAT
GCCTCAGCTAGGATGACAGCGTGGGGACGGCCGGCGGCGTCCCCTGCCCCAGGCCGCGGTGGCGGCGCCGCGACCCCGCCCTCTCGCGCC
TGTCCTTCCCTCTGCTCCCAGCCTTTGCTGGGCGCCAGACCCGGCTTTGCCGTCCGGCTATTAGCCTACTGTGGCTAGTCACCCCCGGGG
TCCCGGCCTTCTCGGGCTGGGGCCGCCGCCACCGCGGCAGGACGGGGAGGCGGGCCATGGCGTCCTGCGTGGGGAGCCGGACCCTAAGCA
AGGATGATGTGAACTACAAAATGCATTTCCGGATGATCAACGAGCAGCAAGTGGAGGACATCACCATTGACTTCTTCTACCGGCCGCATA
CCATCACCCTGCTCAGCTTCACCATCGTCAGCCTCATGTACTTCGCCTTTACCAGGGATGACTCTGTTCCAGAAGACAACATCTGGAGAG
GCATCCTCTCTGTTATTTTCTTCTTTCTTATCATCAGTGTGTTAGCTTTCCCCAATGGTCCGTTCACTCGACCTCATCCAGCCTTATGGC
GAATGGTTTTTGGACTCAGTGTGCTCTACTTCCTGTTCCTGGTATTCCTACTCTTCCTGAATTTCGAGCAGGTTAAATCTCTAATGTATT
GGCTAGATCCAAATCTTCGATACGCCACAAGGGAAGCAGATGTCATGATTCACCTTTTTGGAGTTTTGCTGGCTATTTTAGGAAACTTGG
TGATCAGTATTTCTCTAAATATTCAGAAATATTCTCACCTTCAGCTGGCACAACAAGAGCACCCAAGGCCATACTTCAAGAGTGTGCTGT
GGTGGGGTGGTGTCCTGCTGATGGCCGTGGGAGAGACGGGGAACTTTGCAGCCTATGGATTTGCTCCCATTACTCTGATCGCTCCGTTAG
GCTGTGTGTCTGTTACAGGTAGTGCCATTATTTCTGTTACATTTCTGAAAGACAATTTGAGAGCCTCAGACTTACTCGGTACGACACTGG
CATTTGCAGGAACATATTTACTGGTGAACTTTGCTCCAAATATAACTCAGGCAATCTCAGCAAGAACAGTACAGTATTACCTTGTCGGAT
GGCAGTTCCTGATCTATGTGATTTTAGAAATATTAATTTTCTGCATTCTCCTGTATTTCTATAAAAGAAAAGGAATGAAGCATATGGTGA
TTCTGCTAACCCTGGTGGCAATTCTAGCCTCATTGACTGTTATTTCAGTAAAGGCCGTCTCAGGCATGATCACTTTTTCTGTGATGGATA
AAATGCAACTAACTTACCCCATTTTCTATATCATGTTTATCATCATGATAGCATCTTGTGTTTTCCAAGTCAAGTTCCTGAATCAAGCCA
CGAAACTCTACAATACGACAACAGTGGTGCCAGTTAATCATATTTTCTTTACAATCAGTGCCATCATTGCAGGTATCATATTTTATCAGG
AATTCCTTGGTGCTCCTTTTCTCACTGTATTTATATATCTTTTTGGGTGTTTTCTGTCATTCCTTGGTGTATTTTTGGTCACAAGAAATC
GAGAAAAGGAACATCTGCAACAGTCTTATATTGATTTTGGAAATATTCCTGGGAAACAAATGTTGGACAAAATACAACCAGATTCACATA
GCTTATCCTATGGAACTTTGCCTGATGGAAGTGACTCAACAAAGAGCCAAAGTGGAGAGAAGAAAGAGGTCTAAATGCTGAGAAGGATGG
CTGTTGGCCTGTTATTCGATACCACCTTTTTAAAAAATTGCACATGTTCAATTTGTGTCAGCAGCTCTTTTATAAGCTAACATGTGCTAG
CATTCATTTCAGTCCTTTCCCCCACCTCAGCGTCTATGGACAATCGGGGACTTCCTAAGCTCTGACAGTCTAATATTTCCATGGAATGTG
ATTTGGAGTGTTCCCCACACCCTGGACCTCTCCCTAGTGATTATCTAGCCAGCTACACCTTACTCAGAGCCCGGCTGCTCTAGCAGGAAT
GTTGCACAGAAACATACATTTGCGGTTTGGCCACAGGTCGCATAGGTGGCTTCTCCCACGGGTAGTGTCAGTTGCTTCACTTTAAAAAGT
CACTTCAGCCCCACAACCTCACTCCCAAAAGAAAGGTTTGAGAGCGCTCATTTTTTTTCTAAGACACCTTTTATAAGCCTCCCTATAAAA
ATCTCACCTTTCAAGTACTAAGTTAGAATTGCAAGTCATCTTTTCTGAAAACTAATGCTATCAAAGTCCTCCTTTGAAAATTAAGGGTCT
CTTTAAAATTAGAATTTATAAATGGCATTCAGTGATAGTGTACACCAAAATTAAAAGACCTTGACTGGTGGGCTTTTTACGTGTAAGGAA
GAGGAAGTTTAAGAAGTAGGACTCTGCTTGTTTCAGTAGCCCATGTACTAAAATAGGAACAATGCAGAGATTAGCACAGCCCCTGCACAA
GGCTGACACATAAATTCATGAAGCGTTAGAGACAAAAAGTAGGACTAATGTTTGTTTATTTTTTAATAAAAATCTAGAATGGTGATGTTT
TCTTCAGCTGTATGATTCTATCATACTTGAAACTGAAGAAAAATTTAATATCCTATGTCTTTTTTATAGATCTTATAATTTATCAAGTGG
ATTTATATGTCTTATTCTCCATATAAGTCTAAAAAATCACATTTAAATTCTTAGTGATAGTTTCACTACACATCATTTCTTCCCAAAGTC
ATTACCTCAAGCTTTGTAAATTCTTCTAGATAAAAGGAGAGTTGTGATTAGAGAACTGAATTTCAGCCATTTAAACCTGTAGACATAGAA
AACAACCCAGTGGTCAAACCTGAGCTTCAAGAGGAAGCCCAAGTCCTCCTGTTTCCTGAATGGCTTTTCCACTCCAATTCATCACATATC
TGCTAAGACACATTTGCAGGTAGAATCCATAATAATATCTGTTATTTATGATCTACCTAATATTTAAAGGAGAAGAAAAGAAGTAGCCTT
CGTTGCAGCCAACATCCAACAATAAGTCCCACCCTTAATGACATTTCAAAGCCTTCAGATCACTTCTGACATGTCTGTCCAATATCATTC
CAATCAATAGTCTTGCATTTAAATAGGTTGTTTAACTCGGTGGTATTGAGACTGTAACCTTAATGGCTCAGGTCTTTTAGCTTTGTTCTT
TGTCATAATCTGCACTCCTGGCCAGACTGACCAAACCTGGCTGCAAAGGAAAGAGATTTGAATTGATCACCAATGTATGAAAAATACAGA
ACCCATGTCTGGCTCCTAAACTCCTGGTAATAATTCCCGCCATCGTAGCAAGTGTCCCATGCATTCAGATAAAGCAGTCATAATTTATGG
TGTATTTTACCGAATTGGTCCAGCATATTGGTCCTACAAGGCTCAGCCAAGAAATGTATCTGGTGCCTTAAACTACAGATTTCTGGTGAC
TCTTAAAACTGGTTTACAAAGATTGAGAAAACAATTAGATTGAAGAGTTTTGCTTCAAGTAGACCTGCATTCATAGCTAGAGTGCATGAG
ATTTTCAGCACTGTAGAATTTCACACAGGCACAAGCATAACACCAGTACTTTAGCAGCCGCCAACAGTTGCATCTATTAAACGTTTTGAG
AAATGACATTGACTTATGCACATTTAAGCAATCAACAATGTTTTAGAAGTCCAGGTAACATATAAAATATATTCAGACCTAGTTTTACTT
TCCATATTGTTGCTCCAAAGTAAGGTAAATAGGAGTTTTAGTTGTACTGGCCTGTAAGATTTTTTAAATTACACAGTGCATGACAACAAC
TAAAGCCAACTCAGTCCTTCTCTTGGCATTGTGAGTTGAGGACCTTTAGCCAACTGTTAGCTCATCTGACTATCTGTCTAGACCAAGGGT
CGGCAAAGTTTTCAGTAAAGACCCACAGAGTACATATTTTGGAGTTTGTGTTGTCTGTACCAACAGACAGACATGGTGTCTGTCCCAACT
ACCCAACTCTGCCATTGTAGCACTAAAGCAGCCATAGACAAGATGTAAACAGAAGAGCATGGCTGTGTTCCAGTAAAACTTTATTTACAG
GCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCTGACAGATCATCTGAGGTTAGGAGTTTGGGACCAGCCT
GGTCAACATAGTGAAACCCCATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGACGGTGGGTGCCTGGAGTCCCAGCTACCTGGGAGG
CTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGCGACAGAGTAA
GACTGTCTCAAAAACAAACAAACAAACAAACAAACAAAAACAAGTGGCCAGTCTGTGAGCTATAGTTCCCAACACCTGGTCTAGACTCTT
CTGCCCTTGCTCTGCAGCTTCTTTCCTGTTGATTGGGCATTCAGGGAAGGAGTTTAAAAAGTGACACTCATGGCTCATGACAAATGAGAT
ACTTTGGGAGTGTGGAAACATGGCTTGATATTTGCCTTCAGATATTTTTGCTTATATAAGTTCTAAATGGAAGTGATAAGTTCATTCTTA
GGGTCCAAGTTGAAAGGCAGTGGTTCTTTTGTGAACACCACTAACTACATTCGAAAAGCCTCTCCAATTCCACATTCCAAGTCTATAACA
GCTTTGGAAATGAGTAACAATGACCTCTCATGTAGTAGATTAAAGCAGAGGCCTTTGCCATATGATTGTTTTTTGGCTTAAATGTTTGCT

>69889_69889_2_PTDSS1-NIPAL2_PTDSS1_chr8_97299374_ENST00000517309_NIPAL2_chr8_99266315_ENST00000430223_length(amino acids)=534AA_BP=196
MSFPLLPAFAGRQTRLCRPAISLLWLVTPGVPAFSGWGRRHRGRTGRRAMASCVGSRTLSKDDVNYKMHFRMINEQQVEDITIDFFYRPH
TITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMY
WLDPNLRYATREADVMIHLFGVLLAILGNLVISISLNIQKYSHLQLAQQEHPRPYFKSVLWWGGVLLMAVGETGNFAAYGFAPITLIAPL
GCVSVTGSAIISVTFLKDNLRASDLLGTTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQFLIYVILEILIFCILLYFYKRKGMKHMV
ILLTLVAILASLTVISVKAVSGMITFSVMDKMQLTYPIFYIMFIIMIASCVFQVKFLNQATKLYNTTTVVPVNHIFFTISAIIAGIIFYQ

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Top

Fusion Gene PPI Analysis for PTDSS1-NIPAL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PTDSS1-NIPAL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PTDSS1-NIPAL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source