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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTGES2-MLXIP (FusionGDB2 ID:69962)

Fusion Gene Summary for PTGES2-MLXIP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTGES2-MLXIP
Fusion gene ID: 69962
HgeneTgene
Gene symbol

PTGES2

MLXIP

Gene ID

80142

22877

Gene nameprostaglandin E synthase 2MLX interacting protein
SynonymsC9orf15|GBF-1|GBF1|PGES2|mPGES-2MIR|MONDOA|bHLHe36
Cytomap

9q34.11

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionprostaglandin E synthase 2GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2microsomal prostaglandin E synthase-2prostaglandin-H(2) E-isomeraseMLX-interacting proteinMlx interactorclass E basic helix-loop-helix protein 36transcriptional activator MondoA
Modification date2020031320200329
UniProtAcc.

Q9NP71

Ensembl transtripts involved in fusion geneENST00000277462, ENST00000338961, 
ENST00000483625, 		ENST00000377037, 
ENST00000535996, ENST00000319080, 
ENST00000538698, 
Fusion gene scores* DoF score4 X 9 X 4=14411 X 11 X 6=726
# samples 712
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/726*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTGES2 [Title/Abstract] AND MLXIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTGES2(130884641)-MLXIP(122626238), # samples:3
Anticipated loss of major functional domain due to fusion event.PTGES2-MLXIP seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PTGES2-MLXIP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTGES2-MLXIP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTGES2-MLXIP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PTGES2-MLXIP seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMLXIP

GO:0045944

positive regulation of transcription by RNA polymerase II

11073985


check buttonFusion gene breakpoints across PTGES2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MLXIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A3RB-01APTGES2chr9

130884641

-MLXIPchr12

122626238

+
ChimerDB4BLCATCGA-GC-A3RBPTGES2chr9

130884640

-MLXIPchr12

122626237

+


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Fusion Gene ORF analysis for PTGES2-MLXIP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000277462ENST00000377037PTGES2chr9

130884641

-MLXIPchr12

122626238

+
5CDS-intronENST00000277462ENST00000377037PTGES2chr9

130884640

-MLXIPchr12

122626237

+
5CDS-intronENST00000277462ENST00000535996PTGES2chr9

130884641

-MLXIPchr12

122626238

+
5CDS-intronENST00000277462ENST00000535996PTGES2chr9

130884640

-MLXIPchr12

122626237

+
5CDS-intronENST00000338961ENST00000377037PTGES2chr9

130884641

-MLXIPchr12

122626238

+
5CDS-intronENST00000338961ENST00000377037PTGES2chr9

130884640

-MLXIPchr12

122626237

+
5CDS-intronENST00000338961ENST00000535996PTGES2chr9

130884641

-MLXIPchr12

122626238

+
5CDS-intronENST00000338961ENST00000535996PTGES2chr9

130884640

-MLXIPchr12

122626237

+
Frame-shiftENST00000277462ENST00000319080PTGES2chr9

130884641

-MLXIPchr12

122626238

+
Frame-shiftENST00000277462ENST00000319080PTGES2chr9

130884640

-MLXIPchr12

122626237

+
Frame-shiftENST00000338961ENST00000538698PTGES2chr9

130884641

-MLXIPchr12

122626238

+
Frame-shiftENST00000338961ENST00000538698PTGES2chr9

130884640

-MLXIPchr12

122626237

+
In-frameENST00000277462ENST00000538698PTGES2chr9

130884641

-MLXIPchr12

122626238

+
In-frameENST00000277462ENST00000538698PTGES2chr9

130884640

-MLXIPchr12

122626237

+
In-frameENST00000338961ENST00000319080PTGES2chr9

130884641

-MLXIPchr12

122626238

+
In-frameENST00000338961ENST00000319080PTGES2chr9

130884640

-MLXIPchr12

122626237

+
intron-3CDSENST00000483625ENST00000319080PTGES2chr9

130884641

-MLXIPchr12

122626238

+
intron-3CDSENST00000483625ENST00000319080PTGES2chr9

130884640

-MLXIPchr12

122626237

+
intron-3CDSENST00000483625ENST00000538698PTGES2chr9

130884641

-MLXIPchr12

122626238

+
intron-3CDSENST00000483625ENST00000538698PTGES2chr9

130884640

-MLXIPchr12

122626237

+
intron-intronENST00000483625ENST00000377037PTGES2chr9

130884641

-MLXIPchr12

122626238

+
intron-intronENST00000483625ENST00000377037PTGES2chr9

130884640

-MLXIPchr12

122626237

+
intron-intronENST00000483625ENST00000535996PTGES2chr9

130884641

-MLXIPchr12

122626238

+
intron-intronENST00000483625ENST00000535996PTGES2chr9

130884640

-MLXIPchr12

122626237

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338961PTGES2chr9130884641-ENST00000319080MLXIPchr12122626238+740717507451758337
ENST00000277462PTGES2chr9130884641-ENST00000538698MLXIPchr12122626238+369596712331811192
ENST00000338961PTGES2chr9130884640-ENST00000319080MLXIPchr12122626237+740717507451758337
ENST00000277462PTGES2chr9130884640-ENST00000538698MLXIPchr12122626237+369596712331811192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338961ENST00000319080PTGES2chr9130884641-MLXIPchr12122626238+0.0049697640.99503016
ENST00000277462ENST00000538698PTGES2chr9130884641-MLXIPchr12122626238+0.360530170.63946986
ENST00000338961ENST00000319080PTGES2chr9130884640-MLXIPchr12122626237+0.0049697640.99503016
ENST00000277462ENST00000538698PTGES2chr9130884640-MLXIPchr12122626237+0.360530170.63946986

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Fusion Genomic Features for PTGES2-MLXIP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTGES2chr9130884640-MLXIPchr12122626237+0.0008500140.99915004
PTGES2chr9130884640-MLXIPchr12122626237+0.0008500140.99915004
PTGES2chr9130884640-MLXIPchr12122626237+0.0008500140.99915004
PTGES2chr9130884640-MLXIPchr12122626237+0.0008500140.99915004

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTGES2-MLXIP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130884641/chr12:122626238)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MLXIP

Q9NP71

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTGES2chr9:130884640chr12:122626237ENST00000338961-6790_193335378.0DomainGlutaredoxin
HgenePTGES2chr9:130884641chr12:122626238ENST00000338961-6790_193335378.0DomainGlutaredoxin
HgenePTGES2chr9:130884640chr12:122626237ENST00000338961-67164_165335378.0RegionGlutathione binding
HgenePTGES2chr9:130884641chr12:122626238ENST00000338961-67164_165335378.0RegionGlutathione binding
HgenePTGES2chr9:130884640chr12:122626237ENST00000338961-671_57335378.0Topological domainLumenal
HgenePTGES2chr9:130884641chr12:122626238ENST00000338961-671_57335378.0Topological domainLumenal
HgenePTGES2chr9:130884640chr12:122626237ENST00000338961-6758_74335378.0TransmembraneHelical
HgenePTGES2chr9:130884641chr12:122626238ENST00000338961-6758_74335378.0TransmembraneHelical
TgeneMLXIPchr9:130884640chr12:122626237ENST0000053869879719_769486527.0DomainbHLH
TgeneMLXIPchr9:130884641chr12:122626238ENST0000053869879719_769486527.0DomainbHLH
TgeneMLXIPchr9:130884640chr12:122626237ENST0000053869879769_790486527.0RegionNote=Leucine-zipper
TgeneMLXIPchr9:130884641chr12:122626238ENST0000053869879769_790486527.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTGES2chr9:130884640chr12:122626237ENST00000338961-67263_377335378.0DomainNote=GST C-terminal
HgenePTGES2chr9:130884641chr12:122626238ENST00000338961-67263_377335378.0DomainNote=GST C-terminal
HgenePTGES2chr9:130884640chr12:122626237ENST00000338961-6775_377335378.0Topological domainCytoplasmic
HgenePTGES2chr9:130884641chr12:122626238ENST00000338961-6775_377335378.0Topological domainCytoplasmic
TgeneMLXIPchr9:130884640chr12:122626237ENST000003190801517719_769879920.0DomainbHLH
TgeneMLXIPchr9:130884641chr12:122626238ENST000003190801517719_769879920.0DomainbHLH
TgeneMLXIPchr9:130884640chr12:122626237ENST000003190801517322_445879920.0RegionTransactivation domain
TgeneMLXIPchr9:130884640chr12:122626237ENST00000319080151773_327879920.0RegionRequired for cytoplasmic localization
TgeneMLXIPchr9:130884640chr12:122626237ENST000003190801517769_790879920.0RegionNote=Leucine-zipper
TgeneMLXIPchr9:130884640chr12:122626237ENST0000053869879322_445486527.0RegionTransactivation domain
TgeneMLXIPchr9:130884640chr12:122626237ENST000005386987973_327486527.0RegionRequired for cytoplasmic localization
TgeneMLXIPchr9:130884641chr12:122626238ENST000003190801517322_445879920.0RegionTransactivation domain
TgeneMLXIPchr9:130884641chr12:122626238ENST00000319080151773_327879920.0RegionRequired for cytoplasmic localization
TgeneMLXIPchr9:130884641chr12:122626238ENST000003190801517769_790879920.0RegionNote=Leucine-zipper
TgeneMLXIPchr9:130884641chr12:122626238ENST0000053869879322_445486527.0RegionTransactivation domain
TgeneMLXIPchr9:130884641chr12:122626238ENST000005386987973_327486527.0RegionRequired for cytoplasmic localization


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Fusion Gene Sequence for PTGES2-MLXIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>69962_69962_1_PTGES2-MLXIP_PTGES2_chr9_130884640_ENST00000277462_MLXIP_chr12_122626237_ENST00000538698_length(transcript)=3695nt_BP=967nt
GCTTCAGCTAGGGCGGGGGAGCCCAGCAGAAGGACCGAGCAGCCTGGCACCCCACTTTGCCATCCTCTCCCTGGAAATCTCGGGGTCGGC
GGGCCGGCCGCTTCGCGTGGGCGAAATCAGAGACACGTGGTTTCCAAGGCCCCTTCGGCTCTCCCTGTCCAGCCGCCTGCAGCTGACCCT
GTACCAGTACAAGACGTGTCCCTTCTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTGGTGGAGGTGAACCC
TGTGCGCAGGGCTGAGATCAAGTTCTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCGGGACGGCAGATATG
AAATGCCTGGCACAGTGCTTGGGGTCTAGTATGTAGCTTCCAGAACCCACCCTGCCCCTCTACCTGGGAGGCCAAATGGCAACAACTAAA
TGACTCCTCTGTCATCATCAGCGCCCTCAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTACCCAGCCATGAA
GGCTGTGAACGAGCAGGGCAAGGAGGTGACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAGCAAGTGTATGG
TGGGAAGGAGGCCAGGACGGAGGAGATGAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAATGTGTACCGCAC
GCCCACCGAGGCTCTGGCGTCCTTTGACTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAGTACATGGGTGC
AGCGGCCATGTACCTCATCAGCAAGCGACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAGGCTGCTGACAA
GTGGGTGGCTGCTGTGGGCAAGGACCGGCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGTGGTATTGAGCACGCTGCGGCAG
CTGAGCACCTCCACCTCCATCCTCACAGACCCGGCACAGCTGCCAGAGCAGGCGTCCAAGGCTGTCACCAGGATTGGCAAGAGATTGGGA
GAGTCCTAGCTGCTTAGCTGGCATGTGGCCGCATGAGATGCCAGGAGACCCTTCCCTGCCCATGGAGAGTAGGCTGCGCCCCCCAGCCCT
TCCTGACGCTCAGCCTCGGGGCCTCTCTCCAACTCTGCCGGCCCACCGTGGCATCGGGAGGCCATGCTCAGGTCTGAAGCAGGTTTGGGG
CCTGCTGACAGCAATAGCCCGCCTTTGGGAACCCCTTGCTGTGAACTCTCTCACTCAGTGACCTCAGTCACCAACCTCCTCTGCCCTCGG
GGCAGCCCACACAAAAGGGAAGTGCTGGCCGTGCTGGTCCTGCCCTGCTGGTGGCCTGCCGGGCCTGGCGCCGGTGAGCGGAATCGATGG
GATGAGGGTGACAGGGCCTGCTCCTGTCCTGAGGCCCAGCCTTGTCCCTCCTGCCACGTCCTGTCCACATGCATGCCTCTGCCTGATGCC
CTGCTCCACTCTCTGGTCTGCCCGTGGGGCAGTTGGAAGGCGTCTTTCTTTCTCCCCTCAACTCTGACAGCACCCAGCCCTTGTGGATGG
ACTTGGGCTTCTATTCAGGCTTATGCATGGCAGGCTGCCAGGGGGAAGTGCCTTCTTCAGAGGTCCTCCAGGACACATGTGTGCAGAAAC
GGTGGATGTGGAACACACAGGACCAGAATGGAAGCGTGTGATGCACGGTGGCTGCTCTGGCTGAGAGGCCCTGCTGGGCATGTTTCATCT
GTCCCCTTTTAGCTCCACCTGACATTGCAGGATCCATGGGGACTCAGCCCAGGGCCTTCTCGGATGTCACCTCACCGCTGTGGCCCTTCT
GCCGTTCTTCTCCACTTGGCTCCAGCTGCAGCTGTTGACAGATCAAGCATGTCCTGTGGGAGCTTAGAACCCTGAAGTTCTAGTGTCTGA
AAGATCAGACTCCACGTCCTGCTGTCAGCCTTGTCATCTTGTCTGATGTCTTTCAGCTGGGAGCCCCAAACCAGGACAGTTCTCGGACCA
AAGATGCCCCCACACTCAAAAGTCTGTCCCGTCTTGTGTTTGGAGAAGGAAACAATGTTGGCAGGCAGCACTCTGTGGTGGTCAGCCCTC
AGAGCTGTTTCTAGGCATCTCTCAGATCAGACAGCAAAGAATCTACCCAGATCTGGGCTGGGTGGAGGTGTGGCTGGGCTGGGGGCCATT
CTGAGCCTGCAGTGAGAGTTTGGCCCAGCCTCAGTCCTTGCTCTTCTCTGGCTACCTCTGCAGGGAGCTGCAGGGGCAAGCACTCTCTCC
AGCACTCAGGAAGCCCGGCCGAGGGTACCTCCTCGTGGAAAGAATGCACTTTAAAGCTCTGCTGAGGAGTTCGGAGCCCAGGCTTTCAGG
CGACCTCTGCCCTCCCTGCCTCTCCTCACCCTCCCTCTCTTCCTGCAGGGCCTGGGAAGGGCTTTGAGGGAGCCTGGGAGCCATGTGAAG
AGGGGCACGCCTGGGCTGTCCCACAGTTTAGATCCAGTTGGAGGTTCTCCCTGGCTCCTGCAGGCCTGCGGGGATCTCTCCCCACTTCAG
GCCTCCGGCCAGCTGCCTGCCCTCTTGTCTGTGCTTCAGCCCTGCACAAAAGCAGCTTGGTGACACCACTCAGCCACCCAGAGTACGTGT
TTACAGGCTTTCCAGATCACCTTCCTGTGGGGTGAACGTAATGAGGCGGGGCTGGTCCTTGGAATTTCCCCTGGAAAATGGTAACAGACT
CCATCCTTGACCCGGGGATGAGCATGAAGGCATTGTCCCAAAGGCAGAGGCCACCGTGGTAGGAATTCCACCAAGGCCAGAAGGGAAAAA
GGAAGAACCCACCGTGTCTGGCTGTGCGGGCCCTGGGGAGGGTCGTGAGTGCAGCCCCTCTCTACTTCTGTGCCTTTGTAAAACGTGTAG
ATAACCGCAGTGGTTGGCTGAGCCAAGAACTCTCCTAAATCAGTGGCTTTCTCCCCACCCCTTGCTGGGGAGTCATTTTTAAAAAAATCT
GTGGGATATAAAATTGGCCTCCTGCTGCTTCAGCCTACCTCTCCCTCTGCTGACTTAATGTCGTGATTCTGTTTCTTCAGATATTTAAGG
CTGTTAGGTTGTGTGAGCCTTGAAGTGTGTGTGTGTGTCCCAGCGACTGTCCACTGTCCAGGAGATGCATGTCTTTGTATTGGAGATATT
TCTGTAACTCATTCTCTTGGTGCTCACGATTGCCATGGCCATAGGGCCACAGTGCCGTATCTGCTGCAGACATGATTGTTTCTTGTTCTA
GAGGTTTTCTTGTTTTCGAATCTTGCCTGATGAATCCAGCCAGACCAAGGGGCCTAGATTTGACCTCTGTCCTGGGCTCCTGGGCCAGGT
GCAGGAACATCTGAGGCCACTCTGCTGGCCACCTCCAGTGGGTGCTGACCACAGGATGGGCTTTGTTTACACTCATTTTCACCCTGATTC
TTGCCCCCACTTTCATAAAAGAAACTTCAAAATGCTGACGCTTTGGAGAGTAAGAAAATCAATCTTGGCTGGGCACGGTGGCTCCTGCCT
GTGATCCTAGCACTTTGGGAGGCTGAAGCTGAAGGATCACTTGAGCTCAGGAGTTGGAGACCAACCCTGGCAACATAACAAGACCCTGTC

>69962_69962_1_PTGES2-MLXIP_PTGES2_chr9_130884640_ENST00000277462_MLXIP_chr12_122626237_ENST00000538698_length(amino acids)=192AA_BP=
MLRSEAGLGPADSNSPPLGTPCCELSHSVTSVTNLLCPRGSPHKREVLAVLVLPCWWPAGPGAGERNRWDEGDRACSCPEAQPCPSCHVL
STCMPLPDALLHSLVCPWGSWKASFFLPSTLTAPSPCGWTWASIQAYAWQAARGKCLLQRSSRTHVCRNGGCGTHRTRMEACDARWLLWL

--------------------------------------------------------------
>69962_69962_2_PTGES2-MLXIP_PTGES2_chr9_130884640_ENST00000338961_MLXIP_chr12_122626237_ENST00000319080_length(transcript)=7407nt_BP=1750nt
CTCTCGGGCGCCGGGCGGGGCCATCCCGGGGCTGTCCGCGGAGACGCCTATGCGGTGGAGGCTCCGGGCTTCAGCTAGGGCGGGGGAGCC
CAGCAGAAGGACCGAGCAGCCTGGCACCCCACTTTGCCATCCTCTCCCTGGAAATCTCGGGGTCGGCGGGCCGGCCGCTTCGCGTGGGCG
AAATCAGAGACACGTGGTTTCCAAGGCCCCTTCGGGTTCGGGAAAATTTTATGGTTCGGGTCACAGTAGGAAGCGGACAATGAGGCGGGA
GGGCAGAGAGAACCGCAACACCTGGTGCCGGGTCGGGTCGTTTCCGGGGCTTTCAGTGGCCGGAAGTCGCGGCGCCTGTACTGACTCTAG
GAAGGGCTGGAGTTGTTTTGAATGGGCGCCCGTAAGAGAGGTGGGCAAGTACGTGTTACAGACGGCCACGCCGCCCTTTAGGCGGTCAAG
GTGGGGCGAGGAGACGTTCGCCCCCCTGCAGTCGGCCGGGTCACTACCCAAGAGCCTTTGGAGGCGGAAGCATGGAACGGTCTGCAAACG
TTCCCGAGCGGGCCTCTGCGGCTCTGGCGGGCGTTTCGAACTTGGGCGCCGGGCACACGCCCAGTCCCGAGAGCGCTGAGGGTTCCCTTA
GCGTCGCCCTCACCCCGGCCAACCCGCGGGGCGCCAGAGTCCTGGCCCTTTAAACGCCGCGCGTGCCTCGGCGTCTTCGTTTCGCGCGCC
CGCCCGCGGCGCCGGCGGAGCGAACATGGACCCGGCTGCGCGGGTGGTGCGGGCGCTGTGGCCTGGTGGGTGCGCCTTGGCCTGGAGGCT
GGGAGGCCGCCCCCAGCCGCTGCTACCCACGCAGAGCCGGGCTGGCTTCGCGGGGGCGGCGGGCGGCCCGAGCCCCGTGGCTGCAGCTCG
TAAGGGGAGCCCGCGGCTGCTGGGAGCTGCGGCGCTGGCCCTGGGGGGAGCCCTGGGGCTGTACCACACGGCGCGGTGGCACCTGCGCGC
CCAGGACCTCCACGCAGAGCGCTCAGCCGCGCAGCTCTCCCTGTCCAGCCGCCTGCAGCTGACCCTGTACCAGTACAAGACGTGTCCCTT
CTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTGGTGGAGGTGAACCCTGTGCGCAGGGCTGAGATCAAGTT
CTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCGCAACAACTAAATGACTCCTCTGTCATCATCAGCGCCCT
CAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTACCCAGCCATGAAGGCTGTGAACGAGCAGGGCAAGGAGGT
GACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAGCAAGTGTATGGTGGGAAGGAGGCCAGGACGGAGGAGAT
GAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAATGTGTACCGCACGCCCACCGAGGCTCTGGCGTCCTTTGA
CTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAGTACATGGGTGCAGCGGCCATGTACCTCATCAGCAAGCG
ACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAGGCTGCTGACAAGTGGGTGGCTGCTGTGGGCAAGGACCG
GCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGTGGTATTGAGCACGCTGCGGCAGCTGAGCACCTCCACCTCCATCCTCACA
GACCCGGCACAGCTGCCAGAGCAGGCGTCCAAGGCTGTCACCAGGATTGGCAAGAGATTGGGAGAGTCCTAGCTGCTTAGCTGGCATGTG
GCCGCATGAGATGCCAGGAGACCCTTCCCTGCCCATGGAGAGTAGGCTGCGCCCCCCAGCCCTTCCTGACGCTCAGCCTCGGGGCCTCTC
TCCAACTCTGCCGGCCCACCGTGGCATCGGGAGGCCATGCTCAGGTCTGAAGCAGGTTTGGGGCCTGCTGACAGCAATAGCCCGCCTTTG
GGAACCCCTTGCTGTGAACTCTCTCACTCAGTGACCTCAGTCACCAACCTCCTCTGCCCTCGGGGCAGCCCACACAAAAGGGAAGTGCTG
GCCGTGCTGGTCCTGCCCTGCTGGTGGCCTGCCGGGCCTGGCGCCGGTGAGCGGAATCGATGGGATGAGGGTGACAGGGCCTGCTCCTGT
CCTGAGGCCCAGCCTTGTCCCTCCTGCCACGTCCTGTCCACATGCATGCCTCTGCCTGATGCCCTGCTCCACTCTCTGGTCTGCCCGTGG
GGCAGTTGGAAGGCGTCTTTCTTTCTCCCCTCAACTCTGACAGCACCCAGCCCTTGTGGATGGACTTGGGCTTCTATTCAGGCTTATGCA
TGGCAGGCTGCCAGGGGGAAGTGCCTTCTTCAGAGGTCCTCCAGGACACATGTGTGCAGAAACGGTGGATGTGGAACACACAGGACCAGA
ATGGAAGCGTGTGATGCACGGTGGCTGCTCTGGCTGAGAGGCCCTGCTGGGCATGTTTCATCTGTCCCCTTTTAGCTCCACCTGACATTG
CAGGATCCATGGGGACTCAGCCCAGGGCCTTCTCGGATGTCACCTCACCGCTGTGGCCCTTCTGCCGTTCTTCTCCACTTGGCTCCAGCT
GCAGCTGTTGACAGATCAAGCATGTCCTGTGGGAGCTTAGAACCCTGAAGTTCTAGTGTCTGAAAGATCAGACTCCACGTCCTGCTGTCA
GCCTTGTCATCTTGTCTGATGTCTTTCAGCTGGGAGCCCCAAACCAGGACAGTTCTCGGACCAAAGATGCCCCCACACTCAAAAGTCTGT
CCCGTCTTGTGTTTGGAGAAGGAAACAATGTTGGCAGGCAGCACTCTGTGGTGGTCAGCCCTCAGAGCTGTTTCTAGGCATCTCTCAGAT
CAGACAGCAAAGAATCTACCCAGATCTGGGCTGGGTGGAGGTGTGGCTGGGCTGGGGGCCATTCTGAGCCTGCAGTGAGAGTTTGGCCCA
GCCTCAGTCCTTGCTCTTCTCTGGCTACCTCTGCAGGGAGCTGCAGGGGCAAGCACTCTCTCCAGCACTCAGGAAGCCCGGCCGAGGGTA
CCTCCTCGTGGAAAGAATGCACTTTAAAGCTCTGCTGAGGAGTTCGGAGCCCAGGCTTTCAGGCGACCTCTGCCCTCCCTGCCTCTCCTC
ACCCTCCCTCTCTTCCTGCAGGGCCTGGGAAGGGCTTTGAGGGAGCCTGGGAGCCATGTGAAGAGGGGCACGCCTGGGCTGTCCCACAGT
TTAGATCCAGTTGGAGGTTCTCCCTGGCTCCTGCAGGCCTGCGGGGATCTCTCCCCACTTCAGGCCTCCGGCCAGCTGCCTGCCCTCTTG
TCTGTGCTTCAGCCCTGCACAAAAGCAGCTTGGTGACACCACTCAGCCACCCAGAGTACGTGTTTACAGGCTTTCCAGATCACCTTCCTG
TGGGGTGAACGTAATGAGGCGGGGCTGGTCCTTGGAATTTCCCCTGGAAAATGGTAACAGACTCCATCCTTGACCCGGGGATGAGCATGA
AGGCATTGTCCCAAAGGCAGAGGCCACCGTGGTAGGAATTCCACCAAGGCCAGAAGGGAAAAAGGAAGAACCCACCGTGTCTGGCTGTGC
GGGCCCTGGGGAGGGTCGTGAGTGCAGCCCCTCTCTACTTCTGTGCCTTTGTAAAACGTGTAGATAACCGCAGTGGTTGGCTGAGCCAAG
AACTCTCCTAAATCAGTGGCTTTCTCCCCACCCCTTGCTGGGGAGTCATTTTTAAAAAAATCTGTGGGATATAAAATTGGCCTCCTGCTG
CTTCAGCCTACCTCTCCCTCTGCTGACTTAATGTCGTGATTCTGTTTCTTCAGATATTTAAGGCTGTTAGGTTGTGTGAGCCTTGAAGTG
TGTGTGTGTGTCCCAGCGACTGTCCACTGTCCAGGAGATGCATGTCTTTGTATTGGAGATATTTCTGTAACTCATTCTCTTGGTGCTCAC
GATTGCCATGGCCATAGGGCCACAGTGCCGTATCTGCTGCAGACATGATTGTTTCTTGTTCTAGAGGTTTTCTTGTTTTCGAATCTTGCC
TGATGAATCCAGCCAGACCAAGGGGCCTAGATTTGACCTCTGTCCTGGGCTCCTGGGCCAGGTGCAGGAACATCTGAGGCCACTCTGCTG
GCCACCTCCAGTGGGTGCTGACCACAGGATGGGCTTTGTTTACACTCATTTTCACCCTGATTCTTGCCCCCACTTTCATAAAAGAAACTT
CAAAATGCTGACGCTTTGGAGAGTAAGAAAATCAATCTTGGCTGGGCACGGTGGCTCCTGCCTGTGATCCTAGCACTTTGGGAGGCTGAA
GCTGAAGGATCACTTGAGCTCAGGAGTTGGAGACCAACCCTGGCAACATAACAAGACCCTGTCTCTACAAAAAAAAAAAAAAAAAAAAAA
AATTTAGCCGTGTGTAGCAGTGAGTGCCTGTGGTCCCAGCTACTTGGGCCTGAGGCTGGAGGATTGCTTGAGCCTAGAAGTTGCAGTGAG
CTATGATCATGCCACACTGTACTCCAGCCTGGATGACAGAGTGAAACCCTGCCTCTAAATAAAAGAAAATAGAGGCAGACTGTGGTGGCT
CACGCCTGTAATCCCAGCACTTTGGTAGGCCAAGGCGGGTGGATCACCTGCAGTCAGGAGTTCACAACCAGCCTGACCAACATGGTGAAA
CCCTGTCTATACTAAAAATACAAAACATTAGCCACGTGTGGTGGTACACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGTCAGGAGAAT
CACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCACTCCAGCCTGGGTGACAGAGCAAAACCCTATCTCAAAA
AAAAAAAGAAGAAAAAAATAGAAAATCCAAAAAGAAAAACCAGAAGGCCTGCTGGCGTATAAATCCCTGGGCGGGTTTCTGATAAATTGC
CCTGTGCTGTCAGCCCCTGCACTGCACTGCTGCCTTCCATGGTGGGTGGGAGACCCCAGAGCGGGGCAGGCGCCACTGAGGGCTTTTCTT
GGAGTCGGCCAGCAGGCCACGCAGCATCCGGCACCCTGGGCGGGCTGGCTAGCTGCCTTCTTAGGACATCTCTACTTTGAAGGATTTTAC
CGCAGGAAGCAATAGCAGCGCTGGCCATTGGTGCTGATGACAGCATTGGGTCTGGTTGAGGGGAAGGGGCTGGAAAGCAGCAGACCCCCC
CAGTGCTGCGCATGGTCCCGGAGCTGTCAGCCAGGGGAGTGGGGTCAGCCGTCAGCCAGCCCTCCCATTTCCCGCCCATGGGCCCTGACC
ACACTCCCTTTTCTAGAAGTCAATCCTAAGGTTTCTCTGCTCTGGCTAAGAGGATGTAAATTTGGATTCTTAGAGGGCATGGCACCCCCA
GTCCCTGCCCAGATAAAGTAGCACAGTGGCAGGCAGCACCTCTGTCTGTTGCTGACGTTGGGGGGCTTACACACCCACCTCATCTCCGTG
CACAGCCATGACTGGCCCTGCCGGCAGCTGGGGTGCAGGTAAGGGTCTCTCTCATAGAGGGGAGCTGCAGCTGAGAACTGGCGAGGCCCC
TTCCTCCAAGGCCCTAGCTGGCCCCCGGGTGAACCTGAGGTGGCAGGTTCAGGTTTTCAAGATGGTGAGGTCTCGCTGTCTGCTGGACAG
TACGTTAGGCTCTCAGAACTCATGGGTGTGGAGCTGGGCCTGTCCCGGGCCAGTGGACCCCTGTGTGTGGGGGATTTGGGGTGCTGTGGG
CCTGGTTATGCACTGGCAGATGGACCTTGCTTTGGTCCAGCTCTTTTCCTTACCCTGGCTCTGACGTGGGAAGGCTTGGAGGGCCCGTCT
CATCACCCCCGTTCGCCCTCAGCTGTCCCTTTCCCTTGTCGCCTGGCCGCTGCCTCGCCCGCCTGAGGCCTCCTAGCAGGCAGCCTGGGT
GTGAGTTGAGCCTCTCTCTTTTCCCTCTGGTGGGAAAGTGGCCTTTCCCTCAACACCTGCTCCCCGGCCCCAGAGGAACCCACCTGTTTT
GGAGCTCAGCTTGGCCCAGCGTTTCCTTGGGGAAGGGAAAGGAGGGCTGGACAGCACTGATCCGGGCAGGCAGCGTGTGCAGCAGTGGCC
AGCCAGAGTGCCAAAGATGCACGGGGATGTGGTGTGTGGCTCCGGGCCCTCGACATCTCTGCTTTGGGGGATTTTTACCTTGTCTGCACA
CTTGTCAGGGGAGAGGGGACAGCAAGGTGGGAGGTTGAAGAGCTTTGAGGCTCAGCAGCATGTTTGTGGCATTCGGTGGACACCATGGCC
TTGGGCGGCTGGACAGGTTTTTGTGATGTGAGGGACACGCATGGGGCACATGGTAAGCTTGGCAAGGGCTCCAGGAACGCTGACGAAGGG
TTTTAGGACCCCCACCCCCATGCCTGTACCAGGGCTGGCCTCCAGAGCGGGTGAGGACAGAGCAGCTGTGGGCTTTTCATTCTGAGGTCT
TGGCCCCCCTGGCCACCGCAAGGGACTCTTTGCTTGTCAGGGCTTGCAAAAACCAACCTTCGAGAAAGAAAAGGGAACTCTTCACGTTGA
ATGTTGACTTTGTGTGTATGCGTGTGTGTGTGTGTGTGTGCACGCGCGCGTGTGCGTGTTGACTTCATGGAATTTTGTTTTGTGAAATTC
CCCTCCAATCGTGTCAGAATTTACCTCCATGCCCCAGTCACACTGTTGGTTCTGCGCTCTGAACCTGGGTGTAGCTCATTTGAAGGACTC
TCTTCTGCGTTTCCTAACAGTTATTTGGTGGTCTCAAGAGTTGAGGTTGTGGAGGGTTGGGAGAAACTGAAGTTCTATACATTTCCATAG
AGTTTACATCCTGCAGTTAAAAGGCAGGGAGGGCTCAGCCCGGGCCCCACAGCTCCAGGCCATCCCCTACGGGCTGCCCACAGTGCCCCC
TTTTCTCTAGCCGAATCTTTTTCGAACAGCCCGGGAAAGGAAAACGGATTCACTTGCTGATTTTGTTCACGGCGGAAGCACCATGTTCCG
TTCCTTTTTCAGGTTCAGTTTGTTGTGTAAATGGCGGTTTTTTCTGGTGTGAGCTTTGGTGATGGTGGCAGGGCTCCTTTGAAGAGATGG
TTCCACCTCGTGGTCTGAAGAACAAACCAGAGAAGAGTCTGGTTTGGCCAGAGGCCCCCTCCGGTCCACGTCACCCTGAGTACACCCCTC
TGATTGCTCTGCTGTCAAGAAGCACGTTTCCACCAGCTGTATTCAACACTACAATGCATTTTTTAAACTATATTTGCATCCAAGACAATA

>69962_69962_2_PTGES2-MLXIP_PTGES2_chr9_130884640_ENST00000338961_MLXIP_chr12_122626237_ENST00000319080_length(amino acids)=337AA_BP=
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERS
AAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKF

--------------------------------------------------------------
>69962_69962_3_PTGES2-MLXIP_PTGES2_chr9_130884641_ENST00000277462_MLXIP_chr12_122626238_ENST00000538698_length(transcript)=3695nt_BP=967nt
GCTTCAGCTAGGGCGGGGGAGCCCAGCAGAAGGACCGAGCAGCCTGGCACCCCACTTTGCCATCCTCTCCCTGGAAATCTCGGGGTCGGC
GGGCCGGCCGCTTCGCGTGGGCGAAATCAGAGACACGTGGTTTCCAAGGCCCCTTCGGCTCTCCCTGTCCAGCCGCCTGCAGCTGACCCT
GTACCAGTACAAGACGTGTCCCTTCTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTGGTGGAGGTGAACCC
TGTGCGCAGGGCTGAGATCAAGTTCTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCGGGACGGCAGATATG
AAATGCCTGGCACAGTGCTTGGGGTCTAGTATGTAGCTTCCAGAACCCACCCTGCCCCTCTACCTGGGAGGCCAAATGGCAACAACTAAA
TGACTCCTCTGTCATCATCAGCGCCCTCAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTACCCAGCCATGAA
GGCTGTGAACGAGCAGGGCAAGGAGGTGACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAGCAAGTGTATGG
TGGGAAGGAGGCCAGGACGGAGGAGATGAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAATGTGTACCGCAC
GCCCACCGAGGCTCTGGCGTCCTTTGACTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAGTACATGGGTGC
AGCGGCCATGTACCTCATCAGCAAGCGACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAGGCTGCTGACAA
GTGGGTGGCTGCTGTGGGCAAGGACCGGCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGTGGTATTGAGCACGCTGCGGCAG
CTGAGCACCTCCACCTCCATCCTCACAGACCCGGCACAGCTGCCAGAGCAGGCGTCCAAGGCTGTCACCAGGATTGGCAAGAGATTGGGA
GAGTCCTAGCTGCTTAGCTGGCATGTGGCCGCATGAGATGCCAGGAGACCCTTCCCTGCCCATGGAGAGTAGGCTGCGCCCCCCAGCCCT
TCCTGACGCTCAGCCTCGGGGCCTCTCTCCAACTCTGCCGGCCCACCGTGGCATCGGGAGGCCATGCTCAGGTCTGAAGCAGGTTTGGGG
CCTGCTGACAGCAATAGCCCGCCTTTGGGAACCCCTTGCTGTGAACTCTCTCACTCAGTGACCTCAGTCACCAACCTCCTCTGCCCTCGG
GGCAGCCCACACAAAAGGGAAGTGCTGGCCGTGCTGGTCCTGCCCTGCTGGTGGCCTGCCGGGCCTGGCGCCGGTGAGCGGAATCGATGG
GATGAGGGTGACAGGGCCTGCTCCTGTCCTGAGGCCCAGCCTTGTCCCTCCTGCCACGTCCTGTCCACATGCATGCCTCTGCCTGATGCC
CTGCTCCACTCTCTGGTCTGCCCGTGGGGCAGTTGGAAGGCGTCTTTCTTTCTCCCCTCAACTCTGACAGCACCCAGCCCTTGTGGATGG
ACTTGGGCTTCTATTCAGGCTTATGCATGGCAGGCTGCCAGGGGGAAGTGCCTTCTTCAGAGGTCCTCCAGGACACATGTGTGCAGAAAC
GGTGGATGTGGAACACACAGGACCAGAATGGAAGCGTGTGATGCACGGTGGCTGCTCTGGCTGAGAGGCCCTGCTGGGCATGTTTCATCT
GTCCCCTTTTAGCTCCACCTGACATTGCAGGATCCATGGGGACTCAGCCCAGGGCCTTCTCGGATGTCACCTCACCGCTGTGGCCCTTCT
GCCGTTCTTCTCCACTTGGCTCCAGCTGCAGCTGTTGACAGATCAAGCATGTCCTGTGGGAGCTTAGAACCCTGAAGTTCTAGTGTCTGA
AAGATCAGACTCCACGTCCTGCTGTCAGCCTTGTCATCTTGTCTGATGTCTTTCAGCTGGGAGCCCCAAACCAGGACAGTTCTCGGACCA
AAGATGCCCCCACACTCAAAAGTCTGTCCCGTCTTGTGTTTGGAGAAGGAAACAATGTTGGCAGGCAGCACTCTGTGGTGGTCAGCCCTC
AGAGCTGTTTCTAGGCATCTCTCAGATCAGACAGCAAAGAATCTACCCAGATCTGGGCTGGGTGGAGGTGTGGCTGGGCTGGGGGCCATT
CTGAGCCTGCAGTGAGAGTTTGGCCCAGCCTCAGTCCTTGCTCTTCTCTGGCTACCTCTGCAGGGAGCTGCAGGGGCAAGCACTCTCTCC
AGCACTCAGGAAGCCCGGCCGAGGGTACCTCCTCGTGGAAAGAATGCACTTTAAAGCTCTGCTGAGGAGTTCGGAGCCCAGGCTTTCAGG
CGACCTCTGCCCTCCCTGCCTCTCCTCACCCTCCCTCTCTTCCTGCAGGGCCTGGGAAGGGCTTTGAGGGAGCCTGGGAGCCATGTGAAG
AGGGGCACGCCTGGGCTGTCCCACAGTTTAGATCCAGTTGGAGGTTCTCCCTGGCTCCTGCAGGCCTGCGGGGATCTCTCCCCACTTCAG
GCCTCCGGCCAGCTGCCTGCCCTCTTGTCTGTGCTTCAGCCCTGCACAAAAGCAGCTTGGTGACACCACTCAGCCACCCAGAGTACGTGT
TTACAGGCTTTCCAGATCACCTTCCTGTGGGGTGAACGTAATGAGGCGGGGCTGGTCCTTGGAATTTCCCCTGGAAAATGGTAACAGACT
CCATCCTTGACCCGGGGATGAGCATGAAGGCATTGTCCCAAAGGCAGAGGCCACCGTGGTAGGAATTCCACCAAGGCCAGAAGGGAAAAA
GGAAGAACCCACCGTGTCTGGCTGTGCGGGCCCTGGGGAGGGTCGTGAGTGCAGCCCCTCTCTACTTCTGTGCCTTTGTAAAACGTGTAG
ATAACCGCAGTGGTTGGCTGAGCCAAGAACTCTCCTAAATCAGTGGCTTTCTCCCCACCCCTTGCTGGGGAGTCATTTTTAAAAAAATCT
GTGGGATATAAAATTGGCCTCCTGCTGCTTCAGCCTACCTCTCCCTCTGCTGACTTAATGTCGTGATTCTGTTTCTTCAGATATTTAAGG
CTGTTAGGTTGTGTGAGCCTTGAAGTGTGTGTGTGTGTCCCAGCGACTGTCCACTGTCCAGGAGATGCATGTCTTTGTATTGGAGATATT
TCTGTAACTCATTCTCTTGGTGCTCACGATTGCCATGGCCATAGGGCCACAGTGCCGTATCTGCTGCAGACATGATTGTTTCTTGTTCTA
GAGGTTTTCTTGTTTTCGAATCTTGCCTGATGAATCCAGCCAGACCAAGGGGCCTAGATTTGACCTCTGTCCTGGGCTCCTGGGCCAGGT
GCAGGAACATCTGAGGCCACTCTGCTGGCCACCTCCAGTGGGTGCTGACCACAGGATGGGCTTTGTTTACACTCATTTTCACCCTGATTC
TTGCCCCCACTTTCATAAAAGAAACTTCAAAATGCTGACGCTTTGGAGAGTAAGAAAATCAATCTTGGCTGGGCACGGTGGCTCCTGCCT
GTGATCCTAGCACTTTGGGAGGCTGAAGCTGAAGGATCACTTGAGCTCAGGAGTTGGAGACCAACCCTGGCAACATAACAAGACCCTGTC

>69962_69962_3_PTGES2-MLXIP_PTGES2_chr9_130884641_ENST00000277462_MLXIP_chr12_122626238_ENST00000538698_length(amino acids)=192AA_BP=
MLRSEAGLGPADSNSPPLGTPCCELSHSVTSVTNLLCPRGSPHKREVLAVLVLPCWWPAGPGAGERNRWDEGDRACSCPEAQPCPSCHVL
STCMPLPDALLHSLVCPWGSWKASFFLPSTLTAPSPCGWTWASIQAYAWQAARGKCLLQRSSRTHVCRNGGCGTHRTRMEACDARWLLWL

--------------------------------------------------------------
>69962_69962_4_PTGES2-MLXIP_PTGES2_chr9_130884641_ENST00000338961_MLXIP_chr12_122626238_ENST00000319080_length(transcript)=7407nt_BP=1750nt
CTCTCGGGCGCCGGGCGGGGCCATCCCGGGGCTGTCCGCGGAGACGCCTATGCGGTGGAGGCTCCGGGCTTCAGCTAGGGCGGGGGAGCC
CAGCAGAAGGACCGAGCAGCCTGGCACCCCACTTTGCCATCCTCTCCCTGGAAATCTCGGGGTCGGCGGGCCGGCCGCTTCGCGTGGGCG
AAATCAGAGACACGTGGTTTCCAAGGCCCCTTCGGGTTCGGGAAAATTTTATGGTTCGGGTCACAGTAGGAAGCGGACAATGAGGCGGGA
GGGCAGAGAGAACCGCAACACCTGGTGCCGGGTCGGGTCGTTTCCGGGGCTTTCAGTGGCCGGAAGTCGCGGCGCCTGTACTGACTCTAG
GAAGGGCTGGAGTTGTTTTGAATGGGCGCCCGTAAGAGAGGTGGGCAAGTACGTGTTACAGACGGCCACGCCGCCCTTTAGGCGGTCAAG
GTGGGGCGAGGAGACGTTCGCCCCCCTGCAGTCGGCCGGGTCACTACCCAAGAGCCTTTGGAGGCGGAAGCATGGAACGGTCTGCAAACG
TTCCCGAGCGGGCCTCTGCGGCTCTGGCGGGCGTTTCGAACTTGGGCGCCGGGCACACGCCCAGTCCCGAGAGCGCTGAGGGTTCCCTTA
GCGTCGCCCTCACCCCGGCCAACCCGCGGGGCGCCAGAGTCCTGGCCCTTTAAACGCCGCGCGTGCCTCGGCGTCTTCGTTTCGCGCGCC
CGCCCGCGGCGCCGGCGGAGCGAACATGGACCCGGCTGCGCGGGTGGTGCGGGCGCTGTGGCCTGGTGGGTGCGCCTTGGCCTGGAGGCT
GGGAGGCCGCCCCCAGCCGCTGCTACCCACGCAGAGCCGGGCTGGCTTCGCGGGGGCGGCGGGCGGCCCGAGCCCCGTGGCTGCAGCTCG
TAAGGGGAGCCCGCGGCTGCTGGGAGCTGCGGCGCTGGCCCTGGGGGGAGCCCTGGGGCTGTACCACACGGCGCGGTGGCACCTGCGCGC
CCAGGACCTCCACGCAGAGCGCTCAGCCGCGCAGCTCTCCCTGTCCAGCCGCCTGCAGCTGACCCTGTACCAGTACAAGACGTGTCCCTT
CTGCAGCAAGGTCCGAGCCTTCCTCGACTTCCATGCCCTGCCCTACCAGGTGGTGGAGGTGAACCCTGTGCGCAGGGCTGAGATCAAGTT
CTCCTCCTACAGAAAGGTGCCCATCCTGGTGGCCCAGGAAGGAGAAAGCTCGCAACAACTAAATGACTCCTCTGTCATCATCAGCGCCCT
CAAGACCTACCTGGTGTCGGGGCAGCCCCTGGAAGAGATCATCACCTACTACCCAGCCATGAAGGCTGTGAACGAGCAGGGCAAGGAGGT
GACCGAGTTCGGCAATAAGTACTGGCTCATGCTCAACGAGAAGGAGGCCCAGCAAGTGTATGGTGGGAAGGAGGCCAGGACGGAGGAGAT
GAAGTGGCGGCAGTGGGCGGACGACTGGCTGGTGCACCTGATCTCCCCCAATGTGTACCGCACGCCCACCGAGGCTCTGGCGTCCTTTGA
CTACATTGTCCGCGAGGGCAAGTTCGGAGCCGTGGAGGGTGCCGTGGCCAAGTACATGGGTGCAGCGGCCATGTACCTCATCAGCAAGCG
ACTCAAGAGCAGGCACCGCCTCCAGGACAACGTGCGCGAGGACCTCTATGAGGCTGCTGACAAGTGGGTGGCTGCTGTGGGCAAGGACCG
GCCCTTCATGGGGGGCCAGAAGCCGAATCTCGCTGATTTGTGGTATTGAGCACGCTGCGGCAGCTGAGCACCTCCACCTCCATCCTCACA
GACCCGGCACAGCTGCCAGAGCAGGCGTCCAAGGCTGTCACCAGGATTGGCAAGAGATTGGGAGAGTCCTAGCTGCTTAGCTGGCATGTG
GCCGCATGAGATGCCAGGAGACCCTTCCCTGCCCATGGAGAGTAGGCTGCGCCCCCCAGCCCTTCCTGACGCTCAGCCTCGGGGCCTCTC
TCCAACTCTGCCGGCCCACCGTGGCATCGGGAGGCCATGCTCAGGTCTGAAGCAGGTTTGGGGCCTGCTGACAGCAATAGCCCGCCTTTG
GGAACCCCTTGCTGTGAACTCTCTCACTCAGTGACCTCAGTCACCAACCTCCTCTGCCCTCGGGGCAGCCCACACAAAAGGGAAGTGCTG
GCCGTGCTGGTCCTGCCCTGCTGGTGGCCTGCCGGGCCTGGCGCCGGTGAGCGGAATCGATGGGATGAGGGTGACAGGGCCTGCTCCTGT
CCTGAGGCCCAGCCTTGTCCCTCCTGCCACGTCCTGTCCACATGCATGCCTCTGCCTGATGCCCTGCTCCACTCTCTGGTCTGCCCGTGG
GGCAGTTGGAAGGCGTCTTTCTTTCTCCCCTCAACTCTGACAGCACCCAGCCCTTGTGGATGGACTTGGGCTTCTATTCAGGCTTATGCA
TGGCAGGCTGCCAGGGGGAAGTGCCTTCTTCAGAGGTCCTCCAGGACACATGTGTGCAGAAACGGTGGATGTGGAACACACAGGACCAGA
ATGGAAGCGTGTGATGCACGGTGGCTGCTCTGGCTGAGAGGCCCTGCTGGGCATGTTTCATCTGTCCCCTTTTAGCTCCACCTGACATTG
CAGGATCCATGGGGACTCAGCCCAGGGCCTTCTCGGATGTCACCTCACCGCTGTGGCCCTTCTGCCGTTCTTCTCCACTTGGCTCCAGCT
GCAGCTGTTGACAGATCAAGCATGTCCTGTGGGAGCTTAGAACCCTGAAGTTCTAGTGTCTGAAAGATCAGACTCCACGTCCTGCTGTCA
GCCTTGTCATCTTGTCTGATGTCTTTCAGCTGGGAGCCCCAAACCAGGACAGTTCTCGGACCAAAGATGCCCCCACACTCAAAAGTCTGT
CCCGTCTTGTGTTTGGAGAAGGAAACAATGTTGGCAGGCAGCACTCTGTGGTGGTCAGCCCTCAGAGCTGTTTCTAGGCATCTCTCAGAT
CAGACAGCAAAGAATCTACCCAGATCTGGGCTGGGTGGAGGTGTGGCTGGGCTGGGGGCCATTCTGAGCCTGCAGTGAGAGTTTGGCCCA
GCCTCAGTCCTTGCTCTTCTCTGGCTACCTCTGCAGGGAGCTGCAGGGGCAAGCACTCTCTCCAGCACTCAGGAAGCCCGGCCGAGGGTA
CCTCCTCGTGGAAAGAATGCACTTTAAAGCTCTGCTGAGGAGTTCGGAGCCCAGGCTTTCAGGCGACCTCTGCCCTCCCTGCCTCTCCTC
ACCCTCCCTCTCTTCCTGCAGGGCCTGGGAAGGGCTTTGAGGGAGCCTGGGAGCCATGTGAAGAGGGGCACGCCTGGGCTGTCCCACAGT
TTAGATCCAGTTGGAGGTTCTCCCTGGCTCCTGCAGGCCTGCGGGGATCTCTCCCCACTTCAGGCCTCCGGCCAGCTGCCTGCCCTCTTG
TCTGTGCTTCAGCCCTGCACAAAAGCAGCTTGGTGACACCACTCAGCCACCCAGAGTACGTGTTTACAGGCTTTCCAGATCACCTTCCTG
TGGGGTGAACGTAATGAGGCGGGGCTGGTCCTTGGAATTTCCCCTGGAAAATGGTAACAGACTCCATCCTTGACCCGGGGATGAGCATGA
AGGCATTGTCCCAAAGGCAGAGGCCACCGTGGTAGGAATTCCACCAAGGCCAGAAGGGAAAAAGGAAGAACCCACCGTGTCTGGCTGTGC
GGGCCCTGGGGAGGGTCGTGAGTGCAGCCCCTCTCTACTTCTGTGCCTTTGTAAAACGTGTAGATAACCGCAGTGGTTGGCTGAGCCAAG
AACTCTCCTAAATCAGTGGCTTTCTCCCCACCCCTTGCTGGGGAGTCATTTTTAAAAAAATCTGTGGGATATAAAATTGGCCTCCTGCTG
CTTCAGCCTACCTCTCCCTCTGCTGACTTAATGTCGTGATTCTGTTTCTTCAGATATTTAAGGCTGTTAGGTTGTGTGAGCCTTGAAGTG
TGTGTGTGTGTCCCAGCGACTGTCCACTGTCCAGGAGATGCATGTCTTTGTATTGGAGATATTTCTGTAACTCATTCTCTTGGTGCTCAC
GATTGCCATGGCCATAGGGCCACAGTGCCGTATCTGCTGCAGACATGATTGTTTCTTGTTCTAGAGGTTTTCTTGTTTTCGAATCTTGCC
TGATGAATCCAGCCAGACCAAGGGGCCTAGATTTGACCTCTGTCCTGGGCTCCTGGGCCAGGTGCAGGAACATCTGAGGCCACTCTGCTG
GCCACCTCCAGTGGGTGCTGACCACAGGATGGGCTTTGTTTACACTCATTTTCACCCTGATTCTTGCCCCCACTTTCATAAAAGAAACTT
CAAAATGCTGACGCTTTGGAGAGTAAGAAAATCAATCTTGGCTGGGCACGGTGGCTCCTGCCTGTGATCCTAGCACTTTGGGAGGCTGAA
GCTGAAGGATCACTTGAGCTCAGGAGTTGGAGACCAACCCTGGCAACATAACAAGACCCTGTCTCTACAAAAAAAAAAAAAAAAAAAAAA
AATTTAGCCGTGTGTAGCAGTGAGTGCCTGTGGTCCCAGCTACTTGGGCCTGAGGCTGGAGGATTGCTTGAGCCTAGAAGTTGCAGTGAG
CTATGATCATGCCACACTGTACTCCAGCCTGGATGACAGAGTGAAACCCTGCCTCTAAATAAAAGAAAATAGAGGCAGACTGTGGTGGCT
CACGCCTGTAATCCCAGCACTTTGGTAGGCCAAGGCGGGTGGATCACCTGCAGTCAGGAGTTCACAACCAGCCTGACCAACATGGTGAAA
CCCTGTCTATACTAAAAATACAAAACATTAGCCACGTGTGGTGGTACACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGTCAGGAGAAT
CACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCACTCCAGCCTGGGTGACAGAGCAAAACCCTATCTCAAAA
AAAAAAAGAAGAAAAAAATAGAAAATCCAAAAAGAAAAACCAGAAGGCCTGCTGGCGTATAAATCCCTGGGCGGGTTTCTGATAAATTGC
CCTGTGCTGTCAGCCCCTGCACTGCACTGCTGCCTTCCATGGTGGGTGGGAGACCCCAGAGCGGGGCAGGCGCCACTGAGGGCTTTTCTT
GGAGTCGGCCAGCAGGCCACGCAGCATCCGGCACCCTGGGCGGGCTGGCTAGCTGCCTTCTTAGGACATCTCTACTTTGAAGGATTTTAC
CGCAGGAAGCAATAGCAGCGCTGGCCATTGGTGCTGATGACAGCATTGGGTCTGGTTGAGGGGAAGGGGCTGGAAAGCAGCAGACCCCCC
CAGTGCTGCGCATGGTCCCGGAGCTGTCAGCCAGGGGAGTGGGGTCAGCCGTCAGCCAGCCCTCCCATTTCCCGCCCATGGGCCCTGACC
ACACTCCCTTTTCTAGAAGTCAATCCTAAGGTTTCTCTGCTCTGGCTAAGAGGATGTAAATTTGGATTCTTAGAGGGCATGGCACCCCCA
GTCCCTGCCCAGATAAAGTAGCACAGTGGCAGGCAGCACCTCTGTCTGTTGCTGACGTTGGGGGGCTTACACACCCACCTCATCTCCGTG
CACAGCCATGACTGGCCCTGCCGGCAGCTGGGGTGCAGGTAAGGGTCTCTCTCATAGAGGGGAGCTGCAGCTGAGAACTGGCGAGGCCCC
TTCCTCCAAGGCCCTAGCTGGCCCCCGGGTGAACCTGAGGTGGCAGGTTCAGGTTTTCAAGATGGTGAGGTCTCGCTGTCTGCTGGACAG
TACGTTAGGCTCTCAGAACTCATGGGTGTGGAGCTGGGCCTGTCCCGGGCCAGTGGACCCCTGTGTGTGGGGGATTTGGGGTGCTGTGGG
CCTGGTTATGCACTGGCAGATGGACCTTGCTTTGGTCCAGCTCTTTTCCTTACCCTGGCTCTGACGTGGGAAGGCTTGGAGGGCCCGTCT
CATCACCCCCGTTCGCCCTCAGCTGTCCCTTTCCCTTGTCGCCTGGCCGCTGCCTCGCCCGCCTGAGGCCTCCTAGCAGGCAGCCTGGGT
GTGAGTTGAGCCTCTCTCTTTTCCCTCTGGTGGGAAAGTGGCCTTTCCCTCAACACCTGCTCCCCGGCCCCAGAGGAACCCACCTGTTTT
GGAGCTCAGCTTGGCCCAGCGTTTCCTTGGGGAAGGGAAAGGAGGGCTGGACAGCACTGATCCGGGCAGGCAGCGTGTGCAGCAGTGGCC
AGCCAGAGTGCCAAAGATGCACGGGGATGTGGTGTGTGGCTCCGGGCCCTCGACATCTCTGCTTTGGGGGATTTTTACCTTGTCTGCACA
CTTGTCAGGGGAGAGGGGACAGCAAGGTGGGAGGTTGAAGAGCTTTGAGGCTCAGCAGCATGTTTGTGGCATTCGGTGGACACCATGGCC
TTGGGCGGCTGGACAGGTTTTTGTGATGTGAGGGACACGCATGGGGCACATGGTAAGCTTGGCAAGGGCTCCAGGAACGCTGACGAAGGG
TTTTAGGACCCCCACCCCCATGCCTGTACCAGGGCTGGCCTCCAGAGCGGGTGAGGACAGAGCAGCTGTGGGCTTTTCATTCTGAGGTCT
TGGCCCCCCTGGCCACCGCAAGGGACTCTTTGCTTGTCAGGGCTTGCAAAAACCAACCTTCGAGAAAGAAAAGGGAACTCTTCACGTTGA
ATGTTGACTTTGTGTGTATGCGTGTGTGTGTGTGTGTGTGCACGCGCGCGTGTGCGTGTTGACTTCATGGAATTTTGTTTTGTGAAATTC
CCCTCCAATCGTGTCAGAATTTACCTCCATGCCCCAGTCACACTGTTGGTTCTGCGCTCTGAACCTGGGTGTAGCTCATTTGAAGGACTC
TCTTCTGCGTTTCCTAACAGTTATTTGGTGGTCTCAAGAGTTGAGGTTGTGGAGGGTTGGGAGAAACTGAAGTTCTATACATTTCCATAG
AGTTTACATCCTGCAGTTAAAAGGCAGGGAGGGCTCAGCCCGGGCCCCACAGCTCCAGGCCATCCCCTACGGGCTGCCCACAGTGCCCCC
TTTTCTCTAGCCGAATCTTTTTCGAACAGCCCGGGAAAGGAAAACGGATTCACTTGCTGATTTTGTTCACGGCGGAAGCACCATGTTCCG
TTCCTTTTTCAGGTTCAGTTTGTTGTGTAAATGGCGGTTTTTTCTGGTGTGAGCTTTGGTGATGGTGGCAGGGCTCCTTTGAAGAGATGG
TTCCACCTCGTGGTCTGAAGAACAAACCAGAGAAGAGTCTGGTTTGGCCAGAGGCCCCCTCCGGTCCACGTCACCCTGAGTACACCCCTC
TGATTGCTCTGCTGTCAAGAAGCACGTTTCCACCAGCTGTATTCAACACTACAATGCATTTTTTAAACTATATTTGCATCCAAGACAATA

>69962_69962_4_PTGES2-MLXIP_PTGES2_chr9_130884641_ENST00000338961_MLXIP_chr12_122626238_ENST00000319080_length(amino acids)=337AA_BP=
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERS
AAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKF

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Fusion Gene PPI Analysis for PTGES2-MLXIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTGES2-MLXIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTGES2-MLXIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource