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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTK2-AGO2 (FusionGDB2 ID:70019)

Fusion Gene Summary for PTK2-AGO2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK2-AGO2
Fusion gene ID: 70019
HgeneTgene
Gene symbol

PTK2

AGO2

Gene ID

5747

27161

Gene nameprotein tyrosine kinase 2argonaute RISC catalytic component 2
SynonymsFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAKCASC7|EIF2C2|LINC00980|PPD|Q10
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71protein argonaute-2PAZ Piwi domain proteinargonaute 2, RISC catalytic componentcancer susceptibility candidate 7cancer susceptibility candidate 7 (non-protein coding)eukaryotic translation initiation factor 2C, 2long intergenic non-protein coding RN
Modification date2020032720200327
UniProtAcc.

Q9UKV8

Ensembl transtripts involved in fusion geneENST00000340930, ENST00000395218, 
ENST00000517887, ENST00000519419, 
ENST00000521059, ENST00000522684, 
ENST00000535192, ENST00000519881, 
ENST00000430260, ENST00000517712, 
ENST00000519465, ENST00000519635, 
ENST00000520151, ENST00000520892, 
ENST00000522950, ENST00000538769, 
ENST00000517293, ENST00000519980, 
ENST00000220592, 
Fusion gene scores* DoF score39 X 32 X 15=187205 X 6 X 4=120
# samples 576
** MAII scorelog2(57/18720*10)=-5.03747470541866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTK2 [Title/Abstract] AND AGO2 [Title/Abstract] AND fusion [Title/Abstract]

Germline AGO2 mutations impair RNA interference and human neurological development (pmid: 33199684)
Most frequent breakpointAGO2(141645584)-PTK2(141685598), # samples:3
PTK2(142011224)-AGO2(141595410), # samples:3
Anticipated loss of major functional domain due to fusion event.AGO2-PTK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AGO2-PTK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AGO2-PTK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
PTK2-AGO2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTK2-AGO2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
PTK2-AGO2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

HgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

HgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

HgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

HgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

HgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

HgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

HgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

HgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgenePTK2

GO:0090303

positive regulation of wound healing

26763945

TgeneAGO2

GO:0010501

RNA secondary structure unwinding

19966796

TgeneAGO2

GO:0031054

pre-miRNA processing

16424907|17671087|18178619|19966796

TgeneAGO2

GO:0035087

siRNA loading onto RISC involved in RNA interference

19966796

TgeneAGO2

GO:0035196

production of miRNAs involved in gene silencing by miRNA

19966796|23661684

TgeneAGO2

GO:0035278

miRNA mediated inhibition of translation

17671087|19801630

TgeneAGO2

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

15260970|17524464

TgeneAGO2

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619|19966796

TgeneAGO2

GO:0045766

positive regulation of angiogenesis

27208409

TgeneAGO2

GO:0045947

negative regulation of translational initiation

17524464|19801630

TgeneAGO2

GO:0090625

mRNA cleavage involved in gene silencing by siRNA

15260970

TgeneAGO2

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027


check buttonFusion gene breakpoints across PTK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AGO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01APTK2chr8

142011224

-AGO2chr8

141595410

-
ChimerDB4BRCATCGA-A2-A3XY-01APTK2chr8

141874411

-AGO2chr8

141545668

-
ChimerDB4BRCATCGA-A2-A3XY-01APTK2chr8

142011224

-AGO2chr8

141595410

-
ChimerDB4CESCTCGA-VS-A94Y-01APTK2chr8

142011224

-AGO2chr8

141551457

-
ChimerDB4STADTCGA-HU-A4GH-01APTK2chr8

142011224

-AGO2chr8

141595410

-


Top

Fusion Gene ORF analysis for PTK2-AGO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340930ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000340930ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000395218ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000395218ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000517887ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000517887ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000519419ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000519419ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000521059ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000521059ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000522684ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000522684ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000535192ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
5CDS-intronENST00000535192ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
5UTR-3CDSENST00000340930ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000340930ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000340930ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000340930ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000395218ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000395218ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000395218ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000395218ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000519881ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000519881ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000519881ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000519881ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000521059ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000521059ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000521059ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000521059ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000522684ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000522684ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-3CDSENST00000522684ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-3CDSENST00000522684ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-5UTRENST00000340930ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-5UTRENST00000395218ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-5UTRENST00000519881ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-5UTRENST00000521059ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-5UTRENST00000522684ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
5UTR-intronENST00000340930ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-intronENST00000395218ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-intronENST00000519881ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-intronENST00000521059ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
5UTR-intronENST00000522684ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
Frame-shiftENST00000340930ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
Frame-shiftENST00000395218ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
Frame-shiftENST00000519419ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
Frame-shiftENST00000522684ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
In-frameENST00000517887ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
In-frameENST00000521059ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
In-frameENST00000535192ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000430260ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000430260ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000430260ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000430260ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000430260ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000517712ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000517712ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000517712ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000517712ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000517712ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000517887ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000517887ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000517887ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000517887ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519419ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000519419ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519419ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000519419ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519465ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000519465ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000519465ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519465ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000519465ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519635ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000519635ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000519635ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519635ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000519635ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000519881ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000520151ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000520151ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000520151ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000520151ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000520151ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000520892ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000520892ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000520892ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000520892ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000520892ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000522950ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000522950ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000522950ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000522950ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000522950ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000535192ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000535192ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000535192ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000535192ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000538769ENST00000220592PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-3CDSENST00000538769ENST00000220592PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000538769ENST00000220592PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-3CDSENST00000538769ENST00000519980PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-3CDSENST00000538769ENST00000519980PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-5UTRENST00000430260ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000517712ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000517887ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000519419ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000519465ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000519635ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000520151ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000520892ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000522950ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000535192ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-5UTRENST00000538769ENST00000517293PTK2chr8

142011224

-AGO2chr8

141595410

-
intron-intronENST00000430260ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000430260ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000430260ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000517712ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000517712ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000517712ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000517887ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000519419ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000519465ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000519465ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000519465ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000519635ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000519635ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000519635ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000519881ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000519881ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000520151ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000520151ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000520151ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000520892ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000520892ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000520892ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000522950ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000522950ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000522950ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000535192ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000538769ENST00000517293PTK2chr8

141874411

-AGO2chr8

141545668

-
intron-intronENST00000538769ENST00000517293PTK2chr8

142011224

-AGO2chr8

141551457

-
intron-intronENST00000538769ENST00000519980PTK2chr8

141874411

-AGO2chr8

141545668

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535192PTK2chr8141874411-ENST00000220592AGO2chr8141545668-177148131891286
ENST00000517887PTK2chr8141874411-ENST00000220592AGO2chr8141545668-21788882641298344
ENST00000521059PTK2chr8141874411-ENST00000220592AGO2chr8141545668-19226321011042313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535192ENST00000220592PTK2chr8141874411-AGO2chr8141545668-0.0044981990.9955018
ENST00000517887ENST00000220592PTK2chr8141874411-AGO2chr8141545668-0.0014204520.9985795
ENST00000521059ENST00000220592PTK2chr8141874411-AGO2chr8141545668-0.0011704140.99882954

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Fusion Genomic Features for PTK2-AGO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTK2-AGO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141645584/chr8:141685598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AGO2

Q9UKV8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018235_3480826.0DomainPAZ
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018517_8180826.0DomainPiwi

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-533712_7331501066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-533863_9131501066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-532712_7331501053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-532863_9131501053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-532712_7331501053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-532863_9131501053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-53335_3551501066.0DomainFERM
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-533422_6801501066.0DomainProtein kinase
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-53235_3551501053.0DomainFERM
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-532422_6801501053.0DomainProtein kinase
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-53235_3551501053.0DomainFERM
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-532422_6801501053.0DomainProtein kinase
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-533428_4341501066.0Nucleotide bindingATP
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-533500_5021501066.0Nucleotide bindingATP
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-532428_4341501053.0Nucleotide bindingATP
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-532500_5021501053.0Nucleotide bindingATP
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-532428_4341501053.0Nucleotide bindingATP
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-532500_5021501053.0Nucleotide bindingATP
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519235_348723860.0DomainPAZ
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519517_818723860.0DomainPiwi


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Fusion Gene Sequence for PTK2-AGO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70019_70019_1_PTK2-AGO2_PTK2_chr8_141874411_ENST00000517887_AGO2_chr8_141545668_ENST00000220592_length(transcript)=2178nt_BP=888nt
TAGGAACACAGAGCCATGGGGTCACATTACTAAGCTGGTTTCATTCTGTTCAGTAGCTTGATCTAGCCAGGATGGTCTGTGTTTCAGATT
GCGGAAGCATGAGAAGATTCTGTAACTGAGAGGCATTCTTCAAGCTGCTGGAAAATATTACAGAAGGAACACCTTCCAAATTTTGCTTCA
AGCTCTGAAAAAAGGAGCACACAGGGGAACCTTAGTCTTGCTTGTGGATCGAAGCAAATACTATCACAGCGAGGAACTGGGACTTTGTGT
GCAGACTCCTGGCTTGATCTTTATAGGATTGGGTGTATGTTGTTGGAACTGGCAGGCCAAGAGGCCCTGAAACCAGCAGGTGCCATCTAT
ATGGAGAAAAGCGGATGTAGTCCATTTCCAGTGTGTTGGGCTAAAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCT
TACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAG
CGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTC
AGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAG
GTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTG
AGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTTGGGAAAAGT
GGAAACATTCCAGCAGGCACGACTGTGGACACGAAAATCACCCACCCCACCGAGTTCGACTTCTACCTGTGTAGTCACGCTGGCATCCAG
GGGACAAGCAGGCCTTCGCACTATCACGTCCTCTGGGACGACAATCGTTTCTCCTCTGATGAGCTGCAGATCCTAACCTACCAGCTGTGT
CACACCTACGTGCGCTGCACACGCTCCGTGTCCATCCCAGCGCCAGCATACTACGCTCACCTGGTGGCCTTCCGGGCCAGGTACCACCTG
GTGGATAAGGAACATGACAGTGCTGAAGGAAGCCATACCTCTGGGCAGAGTAACGGGCGAGACCACCAAGCACTGGCCAAGGCGGTCCAG
GTTCACCAAGACACTCTGCGCACCATGTACTTTGCTTGACATGTTTTAGTGTTTAGCGATTGTGTACCGAGTGGGATTCACGAGACCAGC
TACACTCAGACCAACAGATGGCCAGCCCTTCCGTGACAGCCAGCATCGAACATGAGACGTCATTGATTTTATTAGATTCTCCGTTTTCCA
GAATGCCTTCCGTCCCAGATTTCAAACTTGGATTTTGAACTGCAGACCTGTATGAGAACCCAATGTCATAGGAAATATGGTTTGCTAAAA
TCTATAAGCTGCTTATTAAAACAGAGTCCCGTGTGTCCTAAAAATCTCCTAAAACCAGTCTATGAACTCAGGGCTTTAAAACATTTTTAA
TTTATTTGGTCATTCAATTTACTTGTTTTTAATACATGATTCTCTATGAAATTGATGGGCTCAAACTAGCTGTGAATCTTCTGAGAGTGA
AAGCAACACAAAACACAAGTGTGGTTTTAAAGCCTTGAACATTCTGATGTTGTCACTAAAGTTGATTTCCAGGCGATGCTCGTGTGCCCC
TGGCGTGGCTCACCCAAGTTCCTCGACTGAGGGCCGGTGGCCATGCAGAGGCGTCCGCAGGTGCCGTGTTCTGCCAGCACCGCCCTTCAC
CCGGCCTGAACTAAGGAGCAGTGGCAGAAGGTGGGCCCCGTGTGTTTACAGCATTTCCAGGTCCAGAGAGGTTGGCAGACAAGTGCCATT
TTAATAAAAAATGTATTTAAAAAAAGAAAAAAGACAATATACTGACAGTCTAATCATCAGATTTGTCCTATAGGACTGTGACATTTATTT
TCCAAAGTTTTTAAAGAATACGGGTCTGTGGTGATAAATACAGTACAATCCTTTTTCACTGTTATGTCTTTAATGTAAGAGAAGAATATA

>70019_70019_1_PTK2-AGO2_PTK2_chr8_141874411_ENST00000517887_AGO2_chr8_141545668_ENST00000220592_length(amino acids)=344AA_BP=1
MCADSWLDLYRIGCMLLELAGQEALKPAGAIYMEKSGCSPFPVCWAKEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA
MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKY
ELRIRYLPKGFLNQFTEDKPTLNFFYQQVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQ

--------------------------------------------------------------
>70019_70019_2_PTK2-AGO2_PTK2_chr8_141874411_ENST00000521059_AGO2_chr8_141545668_ENST00000220592_length(transcript)=1922nt_BP=632nt
GCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACGGCGCCGAGCCGCGGTCCGAAGTCTTGCTGTGTCACCC
AGGCTGCCAGGCTGGAGTGGAGTGGCATGATCTCGGCTGACTGCAACCTCTGCCTCCCAGAATATGACAGATACCTAGCATCTAGCAAAA
TAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTC
CTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAG
ATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACC
TGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGT
GGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAAC
AGGTTGGGAAAAGTGGAAACATTCCAGCAGGCACGACTGTGGACACGAAAATCACCCACCCCACCGAGTTCGACTTCTACCTGTGTAGTC
ACGCTGGCATCCAGGGGACAAGCAGGCCTTCGCACTATCACGTCCTCTGGGACGACAATCGTTTCTCCTCTGATGAGCTGCAGATCCTAA
CCTACCAGCTGTGTCACACCTACGTGCGCTGCACACGCTCCGTGTCCATCCCAGCGCCAGCATACTACGCTCACCTGGTGGCCTTCCGGG
CCAGGTACCACCTGGTGGATAAGGAACATGACAGTGCTGAAGGAAGCCATACCTCTGGGCAGAGTAACGGGCGAGACCACCAAGCACTGG
CCAAGGCGGTCCAGGTTCACCAAGACACTCTGCGCACCATGTACTTTGCTTGACATGTTTTAGTGTTTAGCGATTGTGTACCGAGTGGGA
TTCACGAGACCAGCTACACTCAGACCAACAGATGGCCAGCCCTTCCGTGACAGCCAGCATCGAACATGAGACGTCATTGATTTTATTAGA
TTCTCCGTTTTCCAGAATGCCTTCCGTCCCAGATTTCAAACTTGGATTTTGAACTGCAGACCTGTATGAGAACCCAATGTCATAGGAAAT
ATGGTTTGCTAAAATCTATAAGCTGCTTATTAAAACAGAGTCCCGTGTGTCCTAAAAATCTCCTAAAACCAGTCTATGAACTCAGGGCTT
TAAAACATTTTTAATTTATTTGGTCATTCAATTTACTTGTTTTTAATACATGATTCTCTATGAAATTGATGGGCTCAAACTAGCTGTGAA
TCTTCTGAGAGTGAAAGCAACACAAAACACAAGTGTGGTTTTAAAGCCTTGAACATTCTGATGTTGTCACTAAAGTTGATTTCCAGGCGA
TGCTCGTGTGCCCCTGGCGTGGCTCACCCAAGTTCCTCGACTGAGGGCCGGTGGCCATGCAGAGGCGTCCGCAGGTGCCGTGTTCTGCCA
GCACCGCCCTTCACCCGGCCTGAACTAAGGAGCAGTGGCAGAAGGTGGGCCCCGTGTGTTTACAGCATTTCCAGGTCCAGAGAGGTTGGC
AGACAAGTGCCATTTTAATAAAAAATGTATTTAAAAAAAGAAAAAAGACAATATACTGACAGTCTAATCATCAGATTTGTCCTATAGGAC
TGTGACATTTATTTTCCAAAGTTTTTAAAGAATACGGGTCTGTGGTGATAAATACAGTACAATCCTTTTTCACTGTTATGTCTTTAATGT

>70019_70019_2_PTK2-AGO2_PTK2_chr8_141874411_ENST00000521059_AGO2_chr8_141545668_ENST00000220592_length(amino acids)=313AA_BP=1
MEWSGMISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATD
VRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVGK
SGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYH

--------------------------------------------------------------
>70019_70019_3_PTK2-AGO2_PTK2_chr8_141874411_ENST00000535192_AGO2_chr8_141545668_ENST00000220592_length(transcript)=1771nt_BP=481nt
ATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGAC
TCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAAC
CACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGT
GGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAA
GTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGA
TAAGCCAACTTTGAATTTCTTCTATCAACAGGTTGGGAAAAGTGGAAACATTCCAGCAGGCACGACTGTGGACACGAAAATCACCCACCC
CACCGAGTTCGACTTCTACCTGTGTAGTCACGCTGGCATCCAGGGGACAAGCAGGCCTTCGCACTATCACGTCCTCTGGGACGACAATCG
TTTCTCCTCTGATGAGCTGCAGATCCTAACCTACCAGCTGTGTCACACCTACGTGCGCTGCACACGCTCCGTGTCCATCCCAGCGCCAGC
ATACTACGCTCACCTGGTGGCCTTCCGGGCCAGGTACCACCTGGTGGATAAGGAACATGACAGTGCTGAAGGAAGCCATACCTCTGGGCA
GAGTAACGGGCGAGACCACCAAGCACTGGCCAAGGCGGTCCAGGTTCACCAAGACACTCTGCGCACCATGTACTTTGCTTGACATGTTTT
AGTGTTTAGCGATTGTGTACCGAGTGGGATTCACGAGACCAGCTACACTCAGACCAACAGATGGCCAGCCCTTCCGTGACAGCCAGCATC
GAACATGAGACGTCATTGATTTTATTAGATTCTCCGTTTTCCAGAATGCCTTCCGTCCCAGATTTCAAACTTGGATTTTGAACTGCAGAC
CTGTATGAGAACCCAATGTCATAGGAAATATGGTTTGCTAAAATCTATAAGCTGCTTATTAAAACAGAGTCCCGTGTGTCCTAAAAATCT
CCTAAAACCAGTCTATGAACTCAGGGCTTTAAAACATTTTTAATTTATTTGGTCATTCAATTTACTTGTTTTTAATACATGATTCTCTAT
GAAATTGATGGGCTCAAACTAGCTGTGAATCTTCTGAGAGTGAAAGCAACACAAAACACAAGTGTGGTTTTAAAGCCTTGAACATTCTGA
TGTTGTCACTAAAGTTGATTTCCAGGCGATGCTCGTGTGCCCCTGGCGTGGCTCACCCAAGTTCCTCGACTGAGGGCCGGTGGCCATGCA
GAGGCGTCCGCAGGTGCCGTGTTCTGCCAGCACCGCCCTTCACCCGGCCTGAACTAAGGAGCAGTGGCAGAAGGTGGGCCCCGTGTGTTT
ACAGCATTTCCAGGTCCAGAGAGGTTGGCAGACAAGTGCCATTTTAATAAAAAATGTATTTAAAAAAAGAAAAAAGACAATATACTGACA
GTCTAATCATCAGATTTGTCCTATAGGACTGTGACATTTATTTTCCAAAGTTTTTAAAGAATACGGGTCTGTGGTGATAAATACAGTACA

>70019_70019_3_PTK2-AGO2_PTK2_chr8_141874411_ENST00000535192_AGO2_chr8_141545668_ENST00000220592_length(amino acids)=286AA_BP=0
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVGKSGNIPAGTTVDTKITHPTEFDFYLCSH
AGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTK2-AGO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519753_761723.0860.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519790_812723.0860.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018311_3160826.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018524_5660826.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018709_7100826.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018753_7610826.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018790_8120826.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018587_5900826.0GW182 family members
TgeneAGO2chr8:141874411chr8:141545668ENST00000519980018650_6600826.0GW182 family members


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTK2chr8:141874411chr8:141545668ENST00000340930-533912_1052150.01066.0ARHGEF28
HgenePTK2chr8:141874411chr8:141545668ENST00000521059-532912_1052150.01053.0ARHGEF28
HgenePTK2chr8:141874411chr8:141545668ENST00000522684-532912_1052150.01053.0ARHGEF28
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519311_316723.0860.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519524_566723.0860.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519709_710723.0860.0guide RNA
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519587_590723.0860.0GW182 family members
TgeneAGO2chr8:141874411chr8:141545668ENST000002205921519650_660723.0860.0GW182 family members


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTK2-AGO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTK2-AGO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource