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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTK2-MKLN1 (FusionGDB2 ID:70042)

Fusion Gene Summary for PTK2-MKLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK2-MKLN1
Fusion gene ID: 70042
HgeneTgene
Gene symbol

PTK2

MKLN1

Gene ID

5747

4289

Gene nameprotein tyrosine kinase 2muskelin 1
SynonymsFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAKTWA2
Cytomap

8q24.3

7q32.3

Type of geneprotein-codingprotein-coding
Descriptionfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71muskelinmuskelin 1, intracellular mediator containing kelch motifs
Modification date2020032720200313
UniProtAcc.

Q9UL63

Ensembl transtripts involved in fusion geneENST00000340930, ENST00000395218, 
ENST00000517887, ENST00000519419, 
ENST00000519465, ENST00000521059, 
ENST00000522684, ENST00000535192, 
ENST00000538769, ENST00000430260, 
ENST00000517712, ENST00000519635, 
ENST00000519881, ENST00000520151, 
ENST00000520892, ENST00000522950, 
ENST00000352689, ENST00000429546, 
ENST00000498778, ENST00000421797, 
Fusion gene scores* DoF score39 X 32 X 15=1872017 X 15 X 7=1785
# samples 5718
** MAII scorelog2(57/18720*10)=-5.03747470541866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1785*10)=-3.30985526258679
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTK2 [Title/Abstract] AND MKLN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTK2(141745350)-MKLN1(131147976), # samples:3
Anticipated loss of major functional domain due to fusion event.PTK2-MKLN1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTK2-MKLN1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
PTK2-MKLN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

HgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

HgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

HgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

HgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

HgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

HgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

HgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

HgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across PTK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MKLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A2H4-01APTK2chr8

141745350

-MKLN1chr7

131147976

+


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Fusion Gene ORF analysis for PTK2-MKLN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340930ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000340930ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000340930ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000395218ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000395218ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000395218ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000517887ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000517887ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000517887ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000519419ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000519419ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000519419ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000519465ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000519465ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000519465ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000521059ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000521059ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000521059ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000522684ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000522684ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000522684ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000535192ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000535192ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000535192ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000538769ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000538769ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
5CDS-intronENST00000538769ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
Frame-shiftENST00000517887ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
Frame-shiftENST00000519465ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
Frame-shiftENST00000521059ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
Frame-shiftENST00000535192ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
Frame-shiftENST00000538769ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
In-frameENST00000340930ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
In-frameENST00000395218ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
In-frameENST00000519419ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
In-frameENST00000522684ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000430260ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000517712ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000519635ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000519881ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000520151ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000520892ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-3CDSENST00000522950ENST00000421797PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000430260ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000430260ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000430260ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000517712ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000517712ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000517712ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000519635ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000519635ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000519635ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000519881ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000519881ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000519881ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000520151ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000520151ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000520151ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000520892ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000520892ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000520892ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000522950ENST00000352689PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000522950ENST00000429546PTK2chr8

141745350

-MKLN1chr7

131147976

+
intron-intronENST00000522950ENST00000498778PTK2chr8

141745350

-MKLN1chr7

131147976

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000522684PTK2chr8141745350-ENST00000421797MKLN1chr7131147976+305922602302296688
ENST00000395218PTK2chr8141745350-ENST00000421797MKLN1chr7131147976+305922602302296688
ENST00000340930PTK2chr8141745350-ENST00000421797MKLN1chr7131147976+298421851552221688
ENST00000519419PTK2chr8141745350-ENST00000421797MKLN1chr7131147976+327324742702510746

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000522684ENST00000421797PTK2chr8141745350-MKLN1chr7131147976+0.0014030.99859697
ENST00000395218ENST00000421797PTK2chr8141745350-MKLN1chr7131147976+0.0014030.99859697
ENST00000340930ENST00000421797PTK2chr8141745350-MKLN1chr7131147976+0.001397680.99860233
ENST00000519419ENST00000421797PTK2chr8141745350-MKLN1chr7131147976+0.0011848330.9988152

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Fusion Genomic Features for PTK2-MKLN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTK2chr8141745349-MKLN1chr7131147975+0.000100150.99989986
PTK2chr8141745349-MKLN1chr7131147975+0.000100150.99989986

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTK2-MKLN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141745350/chr7:131147976)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MKLN1

Q9UL63

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924). {ECO:0000250|UniProtKB:O89050, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-223335_3556761066.0DomainFERM
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-223235_3556761053.0DomainFERM
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-223235_3556761053.0DomainFERM
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-2233428_4346761066.0Nucleotide bindingATP
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-2233500_5026761066.0Nucleotide bindingATP
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-2232428_4346761053.0Nucleotide bindingATP
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-2232500_5026761053.0Nucleotide bindingATP
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-2232428_4346761053.0Nucleotide bindingATP
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-2232500_5026761053.0Nucleotide bindingATP
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118526_578508736.0RepeatNote=Kelch 5
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118597_651508736.0RepeatNote=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-2233712_7336761066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-2233863_9136761066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-2232712_7336761053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-2232863_9136761053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-2232712_7336761053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-2232863_9136761053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-2233422_6806761066.0DomainProtein kinase
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-2232422_6806761053.0DomainProtein kinase
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-2232422_6806761053.0DomainProtein kinase
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118172_204508736.0DomainLisH
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118206_258508736.0DomainCTLH
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118284_330508736.0RepeatNote=Kelch 1
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118339_391508736.0RepeatNote=Kelch 2
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118408_458508736.0RepeatNote=Kelch 3
TgeneMKLN1chr8:141745350chr7:131147976ENST000003526891118469_515508736.0RepeatNote=Kelch 4


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Fusion Gene Sequence for PTK2-MKLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70042_70042_1_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000340930_MKLN1_chr7_131147976_ENST00000421797_length(transcript)=2984nt_BP=2185nt
TGCCTTCGCTTCACGGCGCCGAGCCGCGGTCCGAGCAGAACTGGGGCTCCCTTGCATCTTCCAGTTACAAATTCAGTGCCTTCTGCAGTT
TCCCCAGAGCTCCTCAAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCA
ACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGG
TCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTC
AGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTC
ACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATT
TGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGA
TAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAG
AAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAA
CACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTC
CAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAG
GAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAG
ACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGA
ATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGG
CTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTG
AGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTG
GAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACT
GTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAG
TCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGG
ATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTG
CTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAG
CTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTG
GTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGG
AAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGT
TTACTGAACTTAAAGCTCAGCTCAGTTCCAATGACAGGATTTACACAGAGAGCAACTATTGATCCAGAACTGAATGAAATACACGTCTTA
TCTGGACTCAGCAAAGATAAGGAAAAGAGGGAAGAAAATGTTAGAAATTCATTCTGGATTTATGACATTGTGAGGAATAGTTGGTCTTGT
GTCTATAAGAATGATCAAGCTGCAAAGGATAATCCAACTAAAAGTCTTCAGGAAGAAGAACCATGTCCAAGGTTTGCCCATCAGCTTGTA
TACGATGAGCTACACAAGGTTCATTACTTATTTGGTGGGAATCCAGGAAAATCTTGCTCTCCAAAGATGAGATTAGATGACTTCTGGTCA
CTGAAGTTGTGTAGACCTTCAAAAGATTATTTACTGAGGCATTGCAAGTACCTCATAAGAAAACACAGGTTTGAAGAAAAGGCCCAAGTG
GATCCCCTTAGTGCTCTGAAATATTTACAAAATGATCTTTATATAACTGTGGATCATTCAGACCCAGAAGAGACAAAAGAGTTTCAGCTC
CTGGCATCAGCTCTATTCAAATCTGGTTCAGATTTTACAGCTCTGGGCTTTTCTGATGTGGATCACACCTATGCTCAAAGAACTCAGCTC
TTTGACACCTTAGTAAATTTCTTTCCTGACAGCATGACTCCTCCTAAAGGCAACCTGGTAGACCTCATCACACTGTAACTGAAGAGTCAC
TGGACACAGAAATGGAAAACAGGAGTCGATTTTCCGTCTTTTGGATTGCAGCTCCACTGACTGACAGTAAAGCTGCAGTGATTGAGGACT

>70042_70042_1_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000340930_MKLN1_chr7_131147976_ENST00000421797_length(amino acids)=688AA_BP=
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND

--------------------------------------------------------------
>70042_70042_2_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000395218_MKLN1_chr7_131147976_ENST00000421797_length(transcript)=3059nt_BP=2260nt
GACCACTGTGAGCCCGCGGCGTGAGGCGTGGGAGGAAGCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACG
GCGCCGAGCCGCGGTCCGAGCAGAACTGGGGCTCCCTTGCATCTTCCAGTTACAAATTCAGTGCCTTCTGCAGTTTCCCCAGAGCTCCTC
AAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACAC
CAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTG
AAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACA
GTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCG
TCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTC
TAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGG
ACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACT
ATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGA
TCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTG
ATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAA
CGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAG
GAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAA
TAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATAC
CAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAG
AAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTG
GAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCG
TGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATC
CTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGA
TCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGG
TGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAAT
TGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGG
AGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGC
CTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAG
CTCAGCTCAGTTCCAATGACAGGATTTACACAGAGAGCAACTATTGATCCAGAACTGAATGAAATACACGTCTTATCTGGACTCAGCAAA
GATAAGGAAAAGAGGGAAGAAAATGTTAGAAATTCATTCTGGATTTATGACATTGTGAGGAATAGTTGGTCTTGTGTCTATAAGAATGAT
CAAGCTGCAAAGGATAATCCAACTAAAAGTCTTCAGGAAGAAGAACCATGTCCAAGGTTTGCCCATCAGCTTGTATACGATGAGCTACAC
AAGGTTCATTACTTATTTGGTGGGAATCCAGGAAAATCTTGCTCTCCAAAGATGAGATTAGATGACTTCTGGTCACTGAAGTTGTGTAGA
CCTTCAAAAGATTATTTACTGAGGCATTGCAAGTACCTCATAAGAAAACACAGGTTTGAAGAAAAGGCCCAAGTGGATCCCCTTAGTGCT
CTGAAATATTTACAAAATGATCTTTATATAACTGTGGATCATTCAGACCCAGAAGAGACAAAAGAGTTTCAGCTCCTGGCATCAGCTCTA
TTCAAATCTGGTTCAGATTTTACAGCTCTGGGCTTTTCTGATGTGGATCACACCTATGCTCAAAGAACTCAGCTCTTTGACACCTTAGTA
AATTTCTTTCCTGACAGCATGACTCCTCCTAAAGGCAACCTGGTAGACCTCATCACACTGTAACTGAAGAGTCACTGGACACAGAAATGG

>70042_70042_2_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000395218_MKLN1_chr7_131147976_ENST00000421797_length(amino acids)=688AA_BP=
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND

--------------------------------------------------------------
>70042_70042_3_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000519419_MKLN1_chr7_131147976_ENST00000421797_length(transcript)=3273nt_BP=2474nt
TCTCTGACTGCAATGGAAAGAGGAAAGAGAAATTAGAAGTATTTTTTTAAATTGTCATTTGATTTCTTCAGAGTTATTGTGGGCTTCTGA
ACTATTGCGGAAGCATGAGAAGATTCTGTAACTGAGAGGCATTCTTCAAGCTGCTGGAAAATATTACAGAAGGAACACCTTCCAAATTTT
GCTTCAAGCTCTGAAAAAAGGAGCACACAGGGGAACCTTAGTCTTGCTTGTGGATCGAAGCAAATACTATCACAGCGAGGAACTGGGACT
TTGTGTGCAGACTCCTGGCTTGATCTTTATAGGATTGGGTGTATGTTGTTGGAACTGGCAGGCCAAGAGGCCCTGAAACCAGCAGGTGCC
ATCTATATGGAGAAAAGCGGATGTAGTCCATTTCCAGTGTGTTGGGCTAAAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCA
GCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCA
ATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACT
GATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCA
GAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATAT
GAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAG
AGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAG
ATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTG
GATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAA
TTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTG
GCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATT
CAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCA
TCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCT
CAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCA
GAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATA
GAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCA
ATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCAT
ATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAA
GTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTT
GTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAA
GATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCT
AGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATC
GGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGAC
CCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGTTCCAATGACAGGATTTACACAGAGAGCAACTATTGATCCAGAACT
GAATGAAATACACGTCTTATCTGGACTCAGCAAAGATAAGGAAAAGAGGGAAGAAAATGTTAGAAATTCATTCTGGATTTATGACATTGT
GAGGAATAGTTGGTCTTGTGTCTATAAGAATGATCAAGCTGCAAAGGATAATCCAACTAAAAGTCTTCAGGAAGAAGAACCATGTCCAAG
GTTTGCCCATCAGCTTGTATACGATGAGCTACACAAGGTTCATTACTTATTTGGTGGGAATCCAGGAAAATCTTGCTCTCCAAAGATGAG
ATTAGATGACTTCTGGTCACTGAAGTTGTGTAGACCTTCAAAAGATTATTTACTGAGGCATTGCAAGTACCTCATAAGAAAACACAGGTT
TGAAGAAAAGGCCCAAGTGGATCCCCTTAGTGCTCTGAAATATTTACAAAATGATCTTTATATAACTGTGGATCATTCAGACCCAGAAGA
GACAAAAGAGTTTCAGCTCCTGGCATCAGCTCTATTCAAATCTGGTTCAGATTTTACAGCTCTGGGCTTTTCTGATGTGGATCACACCTA
TGCTCAAAGAACTCAGCTCTTTGACACCTTAGTAAATTTCTTTCCTGACAGCATGACTCCTCCTAAAGGCAACCTGGTAGACCTCATCAC
ACTGTAACTGAAGAGTCACTGGACACAGAAATGGAAAACAGGAGTCGATTTTCCGTCTTTTGGATTGCAGCTCCACTGACTGACAGTAAA

>70042_70042_3_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000519419_MKLN1_chr7_131147976_ENST00000421797_length(amino acids)=746AA_BP=
MCADSWLDLYRIGCMLLELAGQEALKPAGAIYMEKSGCSPFPVCWAKEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA
MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKY
ELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLL
DSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTI
QYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS
ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH
IVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME
DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD

--------------------------------------------------------------
>70042_70042_4_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000522684_MKLN1_chr7_131147976_ENST00000421797_length(transcript)=3059nt_BP=2260nt
GACCACTGTGAGCCCGCGGCGTGAGGCGTGGGAGGAAGCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACG
GCGCCGAGCCGCGGTCCGAGCAGAACTGGGGCTCCCTTGCATCTTCCAGTTACAAATTCAGTGCCTTCTGCAGTTTCCCCAGAGCTCCTC
AAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACAC
CAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTG
AAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACA
GTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCG
TCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTC
TAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGG
ACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACT
ATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGA
TCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTG
ATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAA
CGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAG
GAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAA
TAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATAC
CAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAG
AAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTG
GAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCG
TGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATC
CTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGA
TCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGG
TGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAAT
TGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGG
AGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGC
CTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAG
CTCAGCTCAGTTCCAATGACAGGATTTACACAGAGAGCAACTATTGATCCAGAACTGAATGAAATACACGTCTTATCTGGACTCAGCAAA
GATAAGGAAAAGAGGGAAGAAAATGTTAGAAATTCATTCTGGATTTATGACATTGTGAGGAATAGTTGGTCTTGTGTCTATAAGAATGAT
CAAGCTGCAAAGGATAATCCAACTAAAAGTCTTCAGGAAGAAGAACCATGTCCAAGGTTTGCCCATCAGCTTGTATACGATGAGCTACAC
AAGGTTCATTACTTATTTGGTGGGAATCCAGGAAAATCTTGCTCTCCAAAGATGAGATTAGATGACTTCTGGTCACTGAAGTTGTGTAGA
CCTTCAAAAGATTATTTACTGAGGCATTGCAAGTACCTCATAAGAAAACACAGGTTTGAAGAAAAGGCCCAAGTGGATCCCCTTAGTGCT
CTGAAATATTTACAAAATGATCTTTATATAACTGTGGATCATTCAGACCCAGAAGAGACAAAAGAGTTTCAGCTCCTGGCATCAGCTCTA
TTCAAATCTGGTTCAGATTTTACAGCTCTGGGCTTTTCTGATGTGGATCACACCTATGCTCAAAGAACTCAGCTCTTTGACACCTTAGTA
AATTTCTTTCCTGACAGCATGACTCCTCCTAAAGGCAACCTGGTAGACCTCATCACACTGTAACTGAAGAGTCACTGGACACAGAAATGG

>70042_70042_4_PTK2-MKLN1_PTK2_chr8_141745350_ENST00000522684_MKLN1_chr7_131147976_ENST00000421797_length(amino acids)=688AA_BP=
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTK2-MKLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTK2chr8:141745350chr7:131147976ENST00000340930-2233912_1052676.66666666666661066.0ARHGEF28
HgenePTK2chr8:141745350chr7:131147976ENST00000521059-2232912_1052676.66666666666661053.0ARHGEF28
HgenePTK2chr8:141745350chr7:131147976ENST00000522684-2232912_1052676.66666666666661053.0ARHGEF28


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTK2-MKLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTK2-MKLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource