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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTK2-MROH5 (FusionGDB2 ID:70043)

Fusion Gene Summary for PTK2-MROH5

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK2-MROH5
Fusion gene ID: 70043
HgeneTgene
Gene symbol

PTK2

MROH5

Gene ID

5747

389690

Gene nameprotein tyrosine kinase 2maestro heat like repeat family member 5 (gene/pseudogene)
SynonymsFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK-
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71maestro heat-like repeat family member 5
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340930, ENST00000395218, 
ENST00000430260, ENST00000519419, 
ENST00000522684, ENST00000517887, 
ENST00000519465, ENST00000521059, 
ENST00000535192, ENST00000538769, 
ENST00000517712, ENST00000519635, 
ENST00000519881, ENST00000520151, 
ENST00000520892, ENST00000522950, 
ENST00000430863, 
Fusion gene scores* DoF score39 X 32 X 15=187207 X 7 X 8=392
# samples 578
** MAII scorelog2(57/18720*10)=-5.03747470541866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTK2 [Title/Abstract] AND MROH5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTK2(141696731)-MROH5(142490548), # samples:1
Anticipated loss of major functional domain due to fusion event.PTK2-MROH5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTK2-MROH5 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

HgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

HgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

HgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

HgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

HgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

HgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

HgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

HgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across PTK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MROH5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FJ-01APTK2chr8

141696731

-MROH5chr8

142490548

-


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Fusion Gene ORF analysis for PTK2-MROH5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340930ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
Frame-shiftENST00000395218ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
Frame-shiftENST00000430260ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
Frame-shiftENST00000519419ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
Frame-shiftENST00000522684ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
In-frameENST00000517887ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
In-frameENST00000519465ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
In-frameENST00000521059ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
In-frameENST00000535192ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
In-frameENST00000538769ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
intron-3CDSENST00000517712ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
intron-3CDSENST00000519635ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
intron-3CDSENST00000519881ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
intron-3CDSENST00000520151ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
intron-3CDSENST00000520892ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-
intron-3CDSENST00000522950ENST00000430863PTK2chr8

141696731

-MROH5chr8

142490548

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535192PTK2chr8141696731-ENST00000430863MROH5chr8142490548-578824553144791482
ENST00000519465PTK2chr8141696731-ENST00000430863MROH5chr8142490548-4951161817236421156
ENST00000517887PTK2chr8141696731-ENST00000430863MROH5chr8142490548-6333300026450241586
ENST00000521059PTK2chr8141696731-ENST00000430863MROH5chr8142490548-6077274410147681555
ENST00000538769PTK2chr8141696731-ENST00000430863MROH5chr8142490548-491115781236021196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535192ENST00000430863PTK2chr8141696731-MROH5chr8142490548-0.0025487130.99745125
ENST00000519465ENST00000430863PTK2chr8141696731-MROH5chr8142490548-0.0037017230.99629825
ENST00000517887ENST00000430863PTK2chr8141696731-MROH5chr8142490548-0.0036243930.9963756
ENST00000521059ENST00000430863PTK2chr8141696731-MROH5chr8142490548-0.0031499950.99684995
ENST00000538769ENST00000430863PTK2chr8141696731-MROH5chr8142490548-0.0042134390.9957866

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Fusion Genomic Features for PTK2-MROH5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTK2-MROH5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141696731/chr8:142490548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-2733712_7338541066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-2732712_7338541053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-2732712_7338541053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-273335_3558541066.0DomainFERM
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-2733422_6808541066.0DomainProtein kinase
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-273235_3558541053.0DomainFERM
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-2732422_6808541053.0DomainProtein kinase
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-273235_3558541053.0DomainFERM
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-2732422_6808541053.0DomainProtein kinase
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-2733428_4348541066.0Nucleotide bindingATP
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-2733500_5028541066.0Nucleotide bindingATP
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-2732428_4348541053.0Nucleotide bindingATP
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-2732500_5028541053.0Nucleotide bindingATP
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-2732428_4348541053.0Nucleotide bindingATP
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-2732500_5028541053.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-2733863_9138541066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-2732863_9138541053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-2732863_9138541053.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for PTK2-MROH5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70043_70043_1_PTK2-MROH5_PTK2_chr8_141696731_ENST00000517887_MROH5_chr8_142490548_ENST00000430863_length(transcript)=6333nt_BP=3000nt
TAGGAACACAGAGCCATGGGGTCACATTACTAAGCTGGTTTCATTCTGTTCAGTAGCTTGATCTAGCCAGGATGGTCTGTGTTTCAGATT
GCGGAAGCATGAGAAGATTCTGTAACTGAGAGGCATTCTTCAAGCTGCTGGAAAATATTACAGAAGGAACACCTTCCAAATTTTGCTTCA
AGCTCTGAAAAAAGGAGCACACAGGGGAACCTTAGTCTTGCTTGTGGATCGAAGCAAATACTATCACAGCGAGGAACTGGGACTTTGTGT
GCAGACTCCTGGCTTGATCTTTATAGGATTGGGTGTATGTTGTTGGAACTGGCAGGCCAAGAGGCCCTGAAACCAGCAGGTGCCATCTAT
ATGGAGAAAAGCGGATGTAGTCCATTTCCAGTGTGTTGGGCTAAAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCT
TACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAG
CGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTC
AGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAG
GTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTG
AGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGAT
TATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGG
GGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCT
GTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTT
GAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATC
GGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTAT
TCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTA
ACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAA
GAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACA
GATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTT
GGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAA
ACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTG
AAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGG
AAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACAC
AGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGT
ACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGAC
GTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGA
ATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGC
AGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAG
TCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGG
TCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACA
GCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGG
CAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGA
CAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATT
GACAGGGAGGATGGAAGTCTTCAGGGTCCGATGGCCATCAAGTCAGTCCCGTTCCTGAGCACGGATGTGTGGTCCAAGGAGCTGCTGTGG
ACACTCACCACGCCCAGCTGGACCCAACAGGAGCAGTCCCCTGAGAAGGCCTTCCTGTTTACCTACTATGGGCTAATCCTTCAAGCTGAA
AAAAACGGTGCCACGGTCAGGAGACACCTGCAAGCCCTCCTGGAAACATCCCACCAGTGGCCCAAGCAGAGGGAGGGCATGGCTCTGACC
TTGGGGCTGGCGGCCACACGCCACCTGGATGACGTCTGGGCCGTCCTGGACCAGTTTGGCAGGAGCAGGCCCATCAGATGGAGTCTCCCC
AGCTCCTCCCCAAAGAACTCGGAGGACCTGCGCTGGAAATGGGCCAGCAGCACCATCCTCCTGGCATACGGCCAGGTGGCAGCCAAAGCC
CGGGCCCACATCCTCCCGTGGGTGGACAACATCGTGTCCAGGATGGTCTTCTACTTCCACTACAGCTCTTGGGACGAGACCCTGAAGCAG
AGCTTCCTCACAGCCACCCTGATGCTGATGGGTGCGGTGAGCCGGAGTGAGGGCGCCCACAGCTACGAGTTCTTCCAGACCTCTGAGCTC
CTCCAGTGTCTGATGGTTTTGATGGAGAAGGAGCCCCAGGACACTCTGTGCACGCGGAGTCGCCAGCAGGCCATGCACATCGCGTCCAGC
CTCTGCAAGCTGAGGCCTCCCATAGACTTGGAAAGGAAGTCTCAGCTCCTGTCCACCTGCTTCCGCAGCGTGTTTGCCCTGCCACTGCTG
GATGCCCTGGAGAAGCACACCTGCCTCTTTCTGGAGCCTCCCAACATCCAGCTGTGGCCCGTGGCTCGGGAGCGGGCAGGCTGGACGCAC
CAGGGCTGGGGACCCAGGGCAGTTCTTCACTGCTCTGAGCACCTACAGAGCCTGTACAGCAGGACCATGGAGGCGCTGGACTTCATGCTG
CAAAGCCTCATCATGCAGAACCCCACCGCCGACGAGCTGCATTTCCTGCTGTCGCACCTGTACATCTGGCTGGCGTCGGAGAAGGCGCAT
GAGCGGCAGCGGGCTGTGCACAGCTGCATGATCCTCCTCAAATTCCTGAACCACAATGGCTACTTGGACCCAAAAGAGGACTTCAAAAGG
ATTGGGCAATTGGTGGGCATACTGGGGATGCTGTGCCAGGACCCAGACAGGGCCACCCAGCGCTGCAGCCTGGAAGGGGCAAGCCATCTC
TACCAGCTCTTGATGTGCCACAAAACAGGAGAAGCTTTGCAGGCAGAATCACAGGCCCCCAAGGAGCTCTCCCAGGCCCATTCGGACGGA
GCCCCACTCTGGAACAGCAGAGACCAGAAGGCCACTCCCCTGGGCCCCCAGGAGATGGCAAAGAACCACATCTTCCAGCTCTGCAGCTTC
CAAGTCATCAAGGATATCATGCAGCAGCTCACACTGGCAGAGTTGAGCGACCTCATCTGGACGGCCATCGACGGCCTGGGCTCCACCAGC
CCCTTCCGCGTGCAGGCAGCCTCCGAGATGCTGCTCACAGCCGTCCAGGAGCACGGGGCCAAGCTGGAGATCGTTTCCAGCATGGCCCAG
GCCATCCGCCTCCGCCTGTGCTCTGTCCACATCCCGCAAGCCAAGGAAAAGACCCTGCACGCCATCACCCTGCTGGCCCGGAGCCACACC
TGTGAGCTGGTGGCCACCTTCCTGAACATCTCCATCCCCTTGGACAGCCACACCTTCCAGCTGTGGAGGGCCCTGGGGGCTGGGCAGCCC
ACGAGCCACCTGGTGCTGACCACACTGCTGGCCTGTCTGCAGGAGCGACCCCTGCCCACCGGTGCCAGCGACAGCAGCCCCTGCCCCAAG
GAGAAGACCTACCTGCGTTTGCTGGCTGCCATGAACATGCTGCACGAGCTGCAGTTTGCCCGGGAGTTCAAGCAGGCCGTGCAGGAGGGC
TACCCCAAGCTCTTCCTGGCCCTCCTCACCCAGATGCACTATGTCTTGGAGCTGAACCTGCCCAGCGAGCCCTAGCCCAAGCAGCAGGCC
CAGGAGGCGGCCGTGCCCAGCCCCCAAAGCTGCAGCACGTCACTGGAGGCACTGAAGAGCCTGCTGTCCACCACGGGGCACTGGCATGAC
TTTGCCCACCTGGAGCTGCAGGGATCCTGGGAGCTCTTCACCACCATCCACACCTACCCGAAGGGCGTGGGCCTCCTTGCCAGGGCCATG
GTGCAGAACCACTGCAGGCAGATCCCAGCGGTGCTGCGTCAGCTGCTGCCCAGCCTGCAGAGCCCACAGGAGCGTGAGAGGAAGGTGGCC
ATCCTCATCCTCACCAAGTTCCTCTACAGCCCTGTCCTGCTGGAGGTGCTTCCCAAACAAGCTGCCTTGACCGTGCTGGCACAAGGCCTC
CACGACCCCAGCCCTGAGGTCCGCGTGTTGAGTCTGCAGGGCCTAAGCAACATCCTCTTCCACCCAGATAAGGGAAGCCTGCTCCAGGGA
CAGCTGCGGCCCTTGCTCGACGGCTTCTTCCAGAGCAGCGACCAGGTGATCGTGTGCATCATGGGCACCGTGTCAGACACGCTGCACCGC
CTGGGCGCGCAGGGCACAGGGAGTCAGAGCCTCGGCGTTGCCATCAGCACACGCTCCTTCTTTAATGACGAGCGGGACGGGATTCGGGCG
GCAGCCATGGCACTGTTCGGGGACCTGGTGGCGGCCATGGCAGACAGGGAGCTGAGCGGCCTGCGGACCCAGGTGCACCAGAGCATGGTG
CCCCTGCTCCTACACCTGAAGGACCAATGCCCAGCTGTCGCCACGCAGGCCAAGTTCACCTTCTACCGCTGTGCTGTGCTGCTCCGCTGG
CGGCTACTGCACACCCTCTTCTGCACGCTGGCCTGGGAGAGGGGCCTCAGCGCCCGCCACTTCCTCTGGACCTGCCTGATGACCCGCAGC
CAGGAGGAATTCAGCATCCACTTGTCACAGGCCCTCAGCTACCTGCACAGCCACTCCTGCCACATCAAGACCTGGGTGACACTCTTCATA
GGCCACACCATCTGCTACCACCCCCAGGCCGTGTTCCAGATGCTGAATGCTGTGGACACCAACCTGCTGTTCCGCACTTTTGAACATCTC
AGAAGTGACCCTGAGCCCAGCATCCGGGAATTCGCCACCAGCCAGCTCTCCTTCCTCCAGAAGGTGTCGGCCAGACCCAAGCAGTGACCT
CCAGCCATCCTCCCCCACCCACCGCCTTCCCCTCCCGTGTCCACCTGGTCAGCCCTGCCCCATCCGCCCCCCACAGAGCTTGGTTGCATA

>70043_70043_1_PTK2-MROH5_PTK2_chr8_141696731_ENST00000517887_MROH5_chr8_142490548_ENST00000430863_length(amino acids)=1586AA_BP=912
MCADSWLDLYRIGCMLLELAGQEALKPAGAIYMEKSGCSPFPVCWAKEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA
MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKY
ELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLL
DSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTI
QYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS
ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH
IVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME
DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD
PSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHG
ITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRG
SIDREDGSLQGPMAIKSVPFLSTDVWSKELLWTLTTPSWTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQWPKQREGMA
LTLGLAATRHLDDVWAVLDQFGRSRPIRWSLPSSSPKNSEDLRWKWASSTILLAYGQVAAKARAHILPWVDNIVSRMVFYFHYSSWDETL
KQSFLTATLMLMGAVSRSEGAHSYEFFQTSELLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPIDLERKSQLLSTCFRSVFALP
LLDALEKHTCLFLEPPNIQLWPVARERAGWTHQGWGPRAVLHCSEHLQSLYSRTMEALDFMLQSLIMQNPTADELHFLLSHLYIWLASEK
AHERQRAVHSCMILLKFLNHNGYLDPKEDFKRIGQLVGILGMLCQDPDRATQRCSLEGASHLYQLLMCHKTGEALQAESQAPKELSQAHS
DGAPLWNSRDQKATPLGPQEMAKNHIFQLCSFQVIKDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAASEMLLTAVQEHGAKLEIVSSM
AQAIRLRLCSVHIPQAKEKTLHAITLLARSHTCELVATFLNISIPLDSHTFQLWRALGAGQPTSHLVLTTLLACLQERPLPTGASDSSPC

--------------------------------------------------------------
>70043_70043_2_PTK2-MROH5_PTK2_chr8_141696731_ENST00000519465_MROH5_chr8_142490548_ENST00000430863_length(transcript)=4951nt_BP=1618nt
AGCCCTGTTTGCTCTCCGATAAACAAGTCTGTGTATTATAACGTATTGGACAATGATGTCACTTTTATTTCCATAAATGACTCATGTGTG
AGCAAAATTTGAGTAATAGTGTTTTAAGAATATTTCAGCGTAGTAGAGGATTTAAGCAGATCGCTTTGCCTACTTTAATTATATGAAATA
CCAGGAGGTCAGATGTTTAACCTCTTTCAACATATCTGTTTCTTTTCCTGCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGA
TACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGA
TGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAG
AGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGT
CTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCT
GTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTC
CTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCC
TATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGAT
ACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCC
AAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCA
GCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTC
CGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCA
CATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGC
ATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGA
CCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTG
GCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGAT
GGCCATCAAGTCAGTCCCGTTCCTGAGCACGGATGTGTGGTCCAAGGAGCTGCTGTGGACACTCACCACGCCCAGCTGGACCCAACAGGA
GCAGTCCCCTGAGAAGGCCTTCCTGTTTACCTACTATGGGCTAATCCTTCAAGCTGAAAAAAACGGTGCCACGGTCAGGAGACACCTGCA
AGCCCTCCTGGAAACATCCCACCAGTGGCCCAAGCAGAGGGAGGGCATGGCTCTGACCTTGGGGCTGGCGGCCACACGCCACCTGGATGA
CGTCTGGGCCGTCCTGGACCAGTTTGGCAGGAGCAGGCCCATCAGATGGAGTCTCCCCAGCTCCTCCCCAAAGAACTCGGAGGACCTGCG
CTGGAAATGGGCCAGCAGCACCATCCTCCTGGCATACGGCCAGGTGGCAGCCAAAGCCCGGGCCCACATCCTCCCGTGGGTGGACAACAT
CGTGTCCAGGATGGTCTTCTACTTCCACTACAGCTCTTGGGACGAGACCCTGAAGCAGAGCTTCCTCACAGCCACCCTGATGCTGATGGG
TGCGGTGAGCCGGAGTGAGGGCGCCCACAGCTACGAGTTCTTCCAGACCTCTGAGCTCCTCCAGTGTCTGATGGTTTTGATGGAGAAGGA
GCCCCAGGACACTCTGTGCACGCGGAGTCGCCAGCAGGCCATGCACATCGCGTCCAGCCTCTGCAAGCTGAGGCCTCCCATAGACTTGGA
AAGGAAGTCTCAGCTCCTGTCCACCTGCTTCCGCAGCGTGTTTGCCCTGCCACTGCTGGATGCCCTGGAGAAGCACACCTGCCTCTTTCT
GGAGCCTCCCAACATCCAGCTGTGGCCCGTGGCTCGGGAGCGGGCAGGCTGGACGCACCAGGGCTGGGGACCCAGGGCAGTTCTTCACTG
CTCTGAGCACCTACAGAGCCTGTACAGCAGGACCATGGAGGCGCTGGACTTCATGCTGCAAAGCCTCATCATGCAGAACCCCACCGCCGA
CGAGCTGCATTTCCTGCTGTCGCACCTGTACATCTGGCTGGCGTCGGAGAAGGCGCATGAGCGGCAGCGGGCTGTGCACAGCTGCATGAT
CCTCCTCAAATTCCTGAACCACAATGGCTACTTGGACCCAAAAGAGGACTTCAAAAGGATTGGGCAATTGGTGGGCATACTGGGGATGCT
GTGCCAGGACCCAGACAGGGCCACCCAGCGCTGCAGCCTGGAAGGGGCAAGCCATCTCTACCAGCTCTTGATGTGCCACAAAACAGGAGA
AGCTTTGCAGGCAGAATCACAGGCCCCCAAGGAGCTCTCCCAGGCCCATTCGGACGGAGCCCCACTCTGGAACAGCAGAGACCAGAAGGC
CACTCCCCTGGGCCCCCAGGAGATGGCAAAGAACCACATCTTCCAGCTCTGCAGCTTCCAAGTCATCAAGGATATCATGCAGCAGCTCAC
ACTGGCAGAGTTGAGCGACCTCATCTGGACGGCCATCGACGGCCTGGGCTCCACCAGCCCCTTCCGCGTGCAGGCAGCCTCCGAGATGCT
GCTCACAGCCGTCCAGGAGCACGGGGCCAAGCTGGAGATCGTTTCCAGCATGGCCCAGGCCATCCGCCTCCGCCTGTGCTCTGTCCACAT
CCCGCAAGCCAAGGAAAAGACCCTGCACGCCATCACCCTGCTGGCCCGGAGCCACACCTGTGAGCTGGTGGCCACCTTCCTGAACATCTC
CATCCCCTTGGACAGCCACACCTTCCAGCTGTGGAGGGCCCTGGGGGCTGGGCAGCCCACGAGCCACCTGGTGCTGACCACACTGCTGGC
CTGTCTGCAGGAGCGACCCCTGCCCACCGGTGCCAGCGACAGCAGCCCCTGCCCCAAGGAGAAGACCTACCTGCGTTTGCTGGCTGCCAT
GAACATGCTGCACGAGCTGCAGTTTGCCCGGGAGTTCAAGCAGGCCGTGCAGGAGGGCTACCCCAAGCTCTTCCTGGCCCTCCTCACCCA
GATGCACTATGTCTTGGAGCTGAACCTGCCCAGCGAGCCCTAGCCCAAGCAGCAGGCCCAGGAGGCGGCCGTGCCCAGCCCCCAAAGCTG
CAGCACGTCACTGGAGGCACTGAAGAGCCTGCTGTCCACCACGGGGCACTGGCATGACTTTGCCCACCTGGAGCTGCAGGGATCCTGGGA
GCTCTTCACCACCATCCACACCTACCCGAAGGGCGTGGGCCTCCTTGCCAGGGCCATGGTGCAGAACCACTGCAGGCAGATCCCAGCGGT
GCTGCGTCAGCTGCTGCCCAGCCTGCAGAGCCCACAGGAGCGTGAGAGGAAGGTGGCCATCCTCATCCTCACCAAGTTCCTCTACAGCCC
TGTCCTGCTGGAGGTGCTTCCCAAACAAGCTGCCTTGACCGTGCTGGCACAAGGCCTCCACGACCCCAGCCCTGAGGTCCGCGTGTTGAG
TCTGCAGGGCCTAAGCAACATCCTCTTCCACCCAGATAAGGGAAGCCTGCTCCAGGGACAGCTGCGGCCCTTGCTCGACGGCTTCTTCCA
GAGCAGCGACCAGGTGATCGTGTGCATCATGGGCACCGTGTCAGACACGCTGCACCGCCTGGGCGCGCAGGGCACAGGGAGTCAGAGCCT
CGGCGTTGCCATCAGCACACGCTCCTTCTTTAATGACGAGCGGGACGGGATTCGGGCGGCAGCCATGGCACTGTTCGGGGACCTGGTGGC
GGCCATGGCAGACAGGGAGCTGAGCGGCCTGCGGACCCAGGTGCACCAGAGCATGGTGCCCCTGCTCCTACACCTGAAGGACCAATGCCC
AGCTGTCGCCACGCAGGCCAAGTTCACCTTCTACCGCTGTGCTGTGCTGCTCCGCTGGCGGCTACTGCACACCCTCTTCTGCACGCTGGC
CTGGGAGAGGGGCCTCAGCGCCCGCCACTTCCTCTGGACCTGCCTGATGACCCGCAGCCAGGAGGAATTCAGCATCCACTTGTCACAGGC
CCTCAGCTACCTGCACAGCCACTCCTGCCACATCAAGACCTGGGTGACACTCTTCATAGGCCACACCATCTGCTACCACCCCCAGGCCGT
GTTCCAGATGCTGAATGCTGTGGACACCAACCTGCTGTTCCGCACTTTTGAACATCTCAGAAGTGACCCTGAGCCCAGCATCCGGGAATT
CGCCACCAGCCAGCTCTCCTTCCTCCAGAAGGTGTCGGCCAGACCCAAGCAGTGACCTCCAGCCATCCTCCCCCACCCACCGCCTTCCCC
TCCCGTGTCCACCTGGTCAGCCCTGCCCCATCCGCCCCCCACAGAGCTTGGTTGCATAACGTTTTTCCATTTGAAAGAAAGATCTAGATT

>70043_70043_2_PTK2-MROH5_PTK2_chr8_141696731_ENST00000519465_MROH5_chr8_142490548_ENST00000430863_length(amino acids)=1156AA_BP=482
MKYQEVRCLTSFNISVSFPAETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSD
SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNV
LVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP
MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPS
PQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEED
QRWLEKEERFLKPDVRLSRGSIDREDGSLQGPMAIKSVPFLSTDVWSKELLWTLTTPSWTQQEQSPEKAFLFTYYGLILQAEKNGATVRR
HLQALLETSHQWPKQREGMALTLGLAATRHLDDVWAVLDQFGRSRPIRWSLPSSSPKNSEDLRWKWASSTILLAYGQVAAKARAHILPWV
DNIVSRMVFYFHYSSWDETLKQSFLTATLMLMGAVSRSEGAHSYEFFQTSELLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPI
DLERKSQLLSTCFRSVFALPLLDALEKHTCLFLEPPNIQLWPVARERAGWTHQGWGPRAVLHCSEHLQSLYSRTMEALDFMLQSLIMQNP
TADELHFLLSHLYIWLASEKAHERQRAVHSCMILLKFLNHNGYLDPKEDFKRIGQLVGILGMLCQDPDRATQRCSLEGASHLYQLLMCHK
TGEALQAESQAPKELSQAHSDGAPLWNSRDQKATPLGPQEMAKNHIFQLCSFQVIKDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAAS
EMLLTAVQEHGAKLEIVSSMAQAIRLRLCSVHIPQAKEKTLHAITLLARSHTCELVATFLNISIPLDSHTFQLWRALGAGQPTSHLVLTT

--------------------------------------------------------------
>70043_70043_3_PTK2-MROH5_PTK2_chr8_141696731_ENST00000521059_MROH5_chr8_142490548_ENST00000430863_length(transcript)=6077nt_BP=2744nt
GCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACGGCGCCGAGCCGCGGTCCGAAGTCTTGCTGTGTCACCC
AGGCTGCCAGGCTGGAGTGGAGTGGCATGATCTCGGCTGACTGCAACCTCTGCCTCCCAGAATATGACAGATACCTAGCATCTAGCAAAA
TAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTC
CTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAG
ATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACC
TGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGT
GGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAAC
AGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCAT
ACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGA
GTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTA
TTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAG
TGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGC
AAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGA
CGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCA
TCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCT
CTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAG
AAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGG
CGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACC
ATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCAT
TTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCA
AAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGAT
ATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTA
CCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATG
ATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGG
CCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGC
GCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTT
ATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTT
CACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGG
AGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAG
AGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCT
CTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGATGGCCATCAAGTCAGTCCCGTTCCTGAGCACGGATGTGTGGTCCA
AGGAGCTGCTGTGGACACTCACCACGCCCAGCTGGACCCAACAGGAGCAGTCCCCTGAGAAGGCCTTCCTGTTTACCTACTATGGGCTAA
TCCTTCAAGCTGAAAAAAACGGTGCCACGGTCAGGAGACACCTGCAAGCCCTCCTGGAAACATCCCACCAGTGGCCCAAGCAGAGGGAGG
GCATGGCTCTGACCTTGGGGCTGGCGGCCACACGCCACCTGGATGACGTCTGGGCCGTCCTGGACCAGTTTGGCAGGAGCAGGCCCATCA
GATGGAGTCTCCCCAGCTCCTCCCCAAAGAACTCGGAGGACCTGCGCTGGAAATGGGCCAGCAGCACCATCCTCCTGGCATACGGCCAGG
TGGCAGCCAAAGCCCGGGCCCACATCCTCCCGTGGGTGGACAACATCGTGTCCAGGATGGTCTTCTACTTCCACTACAGCTCTTGGGACG
AGACCCTGAAGCAGAGCTTCCTCACAGCCACCCTGATGCTGATGGGTGCGGTGAGCCGGAGTGAGGGCGCCCACAGCTACGAGTTCTTCC
AGACCTCTGAGCTCCTCCAGTGTCTGATGGTTTTGATGGAGAAGGAGCCCCAGGACACTCTGTGCACGCGGAGTCGCCAGCAGGCCATGC
ACATCGCGTCCAGCCTCTGCAAGCTGAGGCCTCCCATAGACTTGGAAAGGAAGTCTCAGCTCCTGTCCACCTGCTTCCGCAGCGTGTTTG
CCCTGCCACTGCTGGATGCCCTGGAGAAGCACACCTGCCTCTTTCTGGAGCCTCCCAACATCCAGCTGTGGCCCGTGGCTCGGGAGCGGG
CAGGCTGGACGCACCAGGGCTGGGGACCCAGGGCAGTTCTTCACTGCTCTGAGCACCTACAGAGCCTGTACAGCAGGACCATGGAGGCGC
TGGACTTCATGCTGCAAAGCCTCATCATGCAGAACCCCACCGCCGACGAGCTGCATTTCCTGCTGTCGCACCTGTACATCTGGCTGGCGT
CGGAGAAGGCGCATGAGCGGCAGCGGGCTGTGCACAGCTGCATGATCCTCCTCAAATTCCTGAACCACAATGGCTACTTGGACCCAAAAG
AGGACTTCAAAAGGATTGGGCAATTGGTGGGCATACTGGGGATGCTGTGCCAGGACCCAGACAGGGCCACCCAGCGCTGCAGCCTGGAAG
GGGCAAGCCATCTCTACCAGCTCTTGATGTGCCACAAAACAGGAGAAGCTTTGCAGGCAGAATCACAGGCCCCCAAGGAGCTCTCCCAGG
CCCATTCGGACGGAGCCCCACTCTGGAACAGCAGAGACCAGAAGGCCACTCCCCTGGGCCCCCAGGAGATGGCAAAGAACCACATCTTCC
AGCTCTGCAGCTTCCAAGTCATCAAGGATATCATGCAGCAGCTCACACTGGCAGAGTTGAGCGACCTCATCTGGACGGCCATCGACGGCC
TGGGCTCCACCAGCCCCTTCCGCGTGCAGGCAGCCTCCGAGATGCTGCTCACAGCCGTCCAGGAGCACGGGGCCAAGCTGGAGATCGTTT
CCAGCATGGCCCAGGCCATCCGCCTCCGCCTGTGCTCTGTCCACATCCCGCAAGCCAAGGAAAAGACCCTGCACGCCATCACCCTGCTGG
CCCGGAGCCACACCTGTGAGCTGGTGGCCACCTTCCTGAACATCTCCATCCCCTTGGACAGCCACACCTTCCAGCTGTGGAGGGCCCTGG
GGGCTGGGCAGCCCACGAGCCACCTGGTGCTGACCACACTGCTGGCCTGTCTGCAGGAGCGACCCCTGCCCACCGGTGCCAGCGACAGCA
GCCCCTGCCCCAAGGAGAAGACCTACCTGCGTTTGCTGGCTGCCATGAACATGCTGCACGAGCTGCAGTTTGCCCGGGAGTTCAAGCAGG
CCGTGCAGGAGGGCTACCCCAAGCTCTTCCTGGCCCTCCTCACCCAGATGCACTATGTCTTGGAGCTGAACCTGCCCAGCGAGCCCTAGC
CCAAGCAGCAGGCCCAGGAGGCGGCCGTGCCCAGCCCCCAAAGCTGCAGCACGTCACTGGAGGCACTGAAGAGCCTGCTGTCCACCACGG
GGCACTGGCATGACTTTGCCCACCTGGAGCTGCAGGGATCCTGGGAGCTCTTCACCACCATCCACACCTACCCGAAGGGCGTGGGCCTCC
TTGCCAGGGCCATGGTGCAGAACCACTGCAGGCAGATCCCAGCGGTGCTGCGTCAGCTGCTGCCCAGCCTGCAGAGCCCACAGGAGCGTG
AGAGGAAGGTGGCCATCCTCATCCTCACCAAGTTCCTCTACAGCCCTGTCCTGCTGGAGGTGCTTCCCAAACAAGCTGCCTTGACCGTGC
TGGCACAAGGCCTCCACGACCCCAGCCCTGAGGTCCGCGTGTTGAGTCTGCAGGGCCTAAGCAACATCCTCTTCCACCCAGATAAGGGAA
GCCTGCTCCAGGGACAGCTGCGGCCCTTGCTCGACGGCTTCTTCCAGAGCAGCGACCAGGTGATCGTGTGCATCATGGGCACCGTGTCAG
ACACGCTGCACCGCCTGGGCGCGCAGGGCACAGGGAGTCAGAGCCTCGGCGTTGCCATCAGCACACGCTCCTTCTTTAATGACGAGCGGG
ACGGGATTCGGGCGGCAGCCATGGCACTGTTCGGGGACCTGGTGGCGGCCATGGCAGACAGGGAGCTGAGCGGCCTGCGGACCCAGGTGC
ACCAGAGCATGGTGCCCCTGCTCCTACACCTGAAGGACCAATGCCCAGCTGTCGCCACGCAGGCCAAGTTCACCTTCTACCGCTGTGCTG
TGCTGCTCCGCTGGCGGCTACTGCACACCCTCTTCTGCACGCTGGCCTGGGAGAGGGGCCTCAGCGCCCGCCACTTCCTCTGGACCTGCC
TGATGACCCGCAGCCAGGAGGAATTCAGCATCCACTTGTCACAGGCCCTCAGCTACCTGCACAGCCACTCCTGCCACATCAAGACCTGGG
TGACACTCTTCATAGGCCACACCATCTGCTACCACCCCCAGGCCGTGTTCCAGATGCTGAATGCTGTGGACACCAACCTGCTGTTCCGCA
CTTTTGAACATCTCAGAAGTGACCCTGAGCCCAGCATCCGGGAATTCGCCACCAGCCAGCTCTCCTTCCTCCAGAAGGTGTCGGCCAGAC
CCAAGCAGTGACCTCCAGCCATCCTCCCCCACCCACCGCCTTCCCCTCCCGTGTCCACCTGGTCAGCCCTGCCCCATCCGCCCCCCACAG

>70043_70043_3_PTK2-MROH5_PTK2_chr8_141696731_ENST00000521059_MROH5_chr8_142490548_ENST00000430863_length(amino acids)=1555AA_BP=881
MEWSGMISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATD
VRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKS
DYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKF
FEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPS
LTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIE
LGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV
RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS
DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRM
ESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAM
WQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPMAIKSVPFLSTDVWSKELL
WTLTTPSWTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQWPKQREGMALTLGLAATRHLDDVWAVLDQFGRSRPIRWSL
PSSSPKNSEDLRWKWASSTILLAYGQVAAKARAHILPWVDNIVSRMVFYFHYSSWDETLKQSFLTATLMLMGAVSRSEGAHSYEFFQTSE
LLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPIDLERKSQLLSTCFRSVFALPLLDALEKHTCLFLEPPNIQLWPVARERAGWT
HQGWGPRAVLHCSEHLQSLYSRTMEALDFMLQSLIMQNPTADELHFLLSHLYIWLASEKAHERQRAVHSCMILLKFLNHNGYLDPKEDFK
RIGQLVGILGMLCQDPDRATQRCSLEGASHLYQLLMCHKTGEALQAESQAPKELSQAHSDGAPLWNSRDQKATPLGPQEMAKNHIFQLCS
FQVIKDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAASEMLLTAVQEHGAKLEIVSSMAQAIRLRLCSVHIPQAKEKTLHAITLLARSH
TCELVATFLNISIPLDSHTFQLWRALGAGQPTSHLVLTTLLACLQERPLPTGASDSSPCPKEKTYLRLLAAMNMLHELQFAREFKQAVQE

--------------------------------------------------------------
>70043_70043_4_PTK2-MROH5_PTK2_chr8_141696731_ENST00000535192_MROH5_chr8_142490548_ENST00000430863_length(transcript)=5788nt_BP=2455nt
ATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGAC
TCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAAC
CACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGT
GGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAA
GTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGA
TAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAA
GTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGA
TGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACA
ATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTG
TGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCC
CACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAAT
AGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCT
GGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGA
AAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCC
CTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCAT
TTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCA
AGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGA
GCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCT
TAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGT
AAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGC
TCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGT
GAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTAC
CCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCT
GGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGA
AGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAA
TCATTACCAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCA
ACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAG
GGAGGATGGAAGTCTTCAGGGTCCGATGGCCATCAAGTCAGTCCCGTTCCTGAGCACGGATGTGTGGTCCAAGGAGCTGCTGTGGACACT
CACCACGCCCAGCTGGACCCAACAGGAGCAGTCCCCTGAGAAGGCCTTCCTGTTTACCTACTATGGGCTAATCCTTCAAGCTGAAAAAAA
CGGTGCCACGGTCAGGAGACACCTGCAAGCCCTCCTGGAAACATCCCACCAGTGGCCCAAGCAGAGGGAGGGCATGGCTCTGACCTTGGG
GCTGGCGGCCACACGCCACCTGGATGACGTCTGGGCCGTCCTGGACCAGTTTGGCAGGAGCAGGCCCATCAGATGGAGTCTCCCCAGCTC
CTCCCCAAAGAACTCGGAGGACCTGCGCTGGAAATGGGCCAGCAGCACCATCCTCCTGGCATACGGCCAGGTGGCAGCCAAAGCCCGGGC
CCACATCCTCCCGTGGGTGGACAACATCGTGTCCAGGATGGTCTTCTACTTCCACTACAGCTCTTGGGACGAGACCCTGAAGCAGAGCTT
CCTCACAGCCACCCTGATGCTGATGGGTGCGGTGAGCCGGAGTGAGGGCGCCCACAGCTACGAGTTCTTCCAGACCTCTGAGCTCCTCCA
GTGTCTGATGGTTTTGATGGAGAAGGAGCCCCAGGACACTCTGTGCACGCGGAGTCGCCAGCAGGCCATGCACATCGCGTCCAGCCTCTG
CAAGCTGAGGCCTCCCATAGACTTGGAAAGGAAGTCTCAGCTCCTGTCCACCTGCTTCCGCAGCGTGTTTGCCCTGCCACTGCTGGATGC
CCTGGAGAAGCACACCTGCCTCTTTCTGGAGCCTCCCAACATCCAGCTGTGGCCCGTGGCTCGGGAGCGGGCAGGCTGGACGCACCAGGG
CTGGGGACCCAGGGCAGTTCTTCACTGCTCTGAGCACCTACAGAGCCTGTACAGCAGGACCATGGAGGCGCTGGACTTCATGCTGCAAAG
CCTCATCATGCAGAACCCCACCGCCGACGAGCTGCATTTCCTGCTGTCGCACCTGTACATCTGGCTGGCGTCGGAGAAGGCGCATGAGCG
GCAGCGGGCTGTGCACAGCTGCATGATCCTCCTCAAATTCCTGAACCACAATGGCTACTTGGACCCAAAAGAGGACTTCAAAAGGATTGG
GCAATTGGTGGGCATACTGGGGATGCTGTGCCAGGACCCAGACAGGGCCACCCAGCGCTGCAGCCTGGAAGGGGCAAGCCATCTCTACCA
GCTCTTGATGTGCCACAAAACAGGAGAAGCTTTGCAGGCAGAATCACAGGCCCCCAAGGAGCTCTCCCAGGCCCATTCGGACGGAGCCCC
ACTCTGGAACAGCAGAGACCAGAAGGCCACTCCCCTGGGCCCCCAGGAGATGGCAAAGAACCACATCTTCCAGCTCTGCAGCTTCCAAGT
CATCAAGGATATCATGCAGCAGCTCACACTGGCAGAGTTGAGCGACCTCATCTGGACGGCCATCGACGGCCTGGGCTCCACCAGCCCCTT
CCGCGTGCAGGCAGCCTCCGAGATGCTGCTCACAGCCGTCCAGGAGCACGGGGCCAAGCTGGAGATCGTTTCCAGCATGGCCCAGGCCAT
CCGCCTCCGCCTGTGCTCTGTCCACATCCCGCAAGCCAAGGAAAAGACCCTGCACGCCATCACCCTGCTGGCCCGGAGCCACACCTGTGA
GCTGGTGGCCACCTTCCTGAACATCTCCATCCCCTTGGACAGCCACACCTTCCAGCTGTGGAGGGCCCTGGGGGCTGGGCAGCCCACGAG
CCACCTGGTGCTGACCACACTGCTGGCCTGTCTGCAGGAGCGACCCCTGCCCACCGGTGCCAGCGACAGCAGCCCCTGCCCCAAGGAGAA
GACCTACCTGCGTTTGCTGGCTGCCATGAACATGCTGCACGAGCTGCAGTTTGCCCGGGAGTTCAAGCAGGCCGTGCAGGAGGGCTACCC
CAAGCTCTTCCTGGCCCTCCTCACCCAGATGCACTATGTCTTGGAGCTGAACCTGCCCAGCGAGCCCTAGCCCAAGCAGCAGGCCCAGGA
GGCGGCCGTGCCCAGCCCCCAAAGCTGCAGCACGTCACTGGAGGCACTGAAGAGCCTGCTGTCCACCACGGGGCACTGGCATGACTTTGC
CCACCTGGAGCTGCAGGGATCCTGGGAGCTCTTCACCACCATCCACACCTACCCGAAGGGCGTGGGCCTCCTTGCCAGGGCCATGGTGCA
GAACCACTGCAGGCAGATCCCAGCGGTGCTGCGTCAGCTGCTGCCCAGCCTGCAGAGCCCACAGGAGCGTGAGAGGAAGGTGGCCATCCT
CATCCTCACCAAGTTCCTCTACAGCCCTGTCCTGCTGGAGGTGCTTCCCAAACAAGCTGCCTTGACCGTGCTGGCACAAGGCCTCCACGA
CCCCAGCCCTGAGGTCCGCGTGTTGAGTCTGCAGGGCCTAAGCAACATCCTCTTCCACCCAGATAAGGGAAGCCTGCTCCAGGGACAGCT
GCGGCCCTTGCTCGACGGCTTCTTCCAGAGCAGCGACCAGGTGATCGTGTGCATCATGGGCACCGTGTCAGACACGCTGCACCGCCTGGG
CGCGCAGGGCACAGGGAGTCAGAGCCTCGGCGTTGCCATCAGCACACGCTCCTTCTTTAATGACGAGCGGGACGGGATTCGGGCGGCAGC
CATGGCACTGTTCGGGGACCTGGTGGCGGCCATGGCAGACAGGGAGCTGAGCGGCCTGCGGACCCAGGTGCACCAGAGCATGGTGCCCCT
GCTCCTACACCTGAAGGACCAATGCCCAGCTGTCGCCACGCAGGCCAAGTTCACCTTCTACCGCTGTGCTGTGCTGCTCCGCTGGCGGCT
ACTGCACACCCTCTTCTGCACGCTGGCCTGGGAGAGGGGCCTCAGCGCCCGCCACTTCCTCTGGACCTGCCTGATGACCCGCAGCCAGGA
GGAATTCAGCATCCACTTGTCACAGGCCCTCAGCTACCTGCACAGCCACTCCTGCCACATCAAGACCTGGGTGACACTCTTCATAGGCCA
CACCATCTGCTACCACCCCCAGGCCGTGTTCCAGATGCTGAATGCTGTGGACACCAACCTGCTGTTCCGCACTTTTGAACATCTCAGAAG
TGACCCTGAGCCCAGCATCCGGGAATTCGCCACCAGCCAGCTCTCCTTCCTCCAGAAGGTGTCGGCCAGACCCAAGCAGTGACCTCCAGC
CATCCTCCCCCACCCACCGCCTTCCCCTCCCGTGTCCACCTGGTCAGCCCTGCCCCATCCGCCCCCCACAGAGCTTGGTTGCATAACGTT

>70043_70043_4_PTK2-MROH5_PTK2_chr8_141696731_ENST00000535192_MROH5_chr8_142490548_ENST00000430863_length(amino acids)=1482AA_BP=808
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND
VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPMA
IKSVPFLSTDVWSKELLWTLTTPSWTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQWPKQREGMALTLGLAATRHLDDV
WAVLDQFGRSRPIRWSLPSSSPKNSEDLRWKWASSTILLAYGQVAAKARAHILPWVDNIVSRMVFYFHYSSWDETLKQSFLTATLMLMGA
VSRSEGAHSYEFFQTSELLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPIDLERKSQLLSTCFRSVFALPLLDALEKHTCLFLE
PPNIQLWPVARERAGWTHQGWGPRAVLHCSEHLQSLYSRTMEALDFMLQSLIMQNPTADELHFLLSHLYIWLASEKAHERQRAVHSCMIL
LKFLNHNGYLDPKEDFKRIGQLVGILGMLCQDPDRATQRCSLEGASHLYQLLMCHKTGEALQAESQAPKELSQAHSDGAPLWNSRDQKAT
PLGPQEMAKNHIFQLCSFQVIKDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAASEMLLTAVQEHGAKLEIVSSMAQAIRLRLCSVHIP
QAKEKTLHAITLLARSHTCELVATFLNISIPLDSHTFQLWRALGAGQPTSHLVLTTLLACLQERPLPTGASDSSPCPKEKTYLRLLAAMN

--------------------------------------------------------------
>70043_70043_5_PTK2-MROH5_PTK2_chr8_141696731_ENST00000538769_MROH5_chr8_142490548_ENST00000430863_length(transcript)=4911nt_BP=1578nt
ATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAA
GGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGAT
GATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAAAAAGCTATGGAATAGATGAAGCCAGGGATTATGAGATTCAA
AGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCT
TTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTT
GACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGG
TCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAG
AGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCC
CGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGT
TTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAAC
AATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGC
TGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAA
GAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCG
GGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCT
GGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCT
CAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATG
GAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGA
CTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGATGGCCATCAAGTCAGTCCCGTTCCTGAGCACGGATGTGTGG
TCCAAGGAGCTGCTGTGGACACTCACCACGCCCAGCTGGACCCAACAGGAGCAGTCCCCTGAGAAGGCCTTCCTGTTTACCTACTATGGG
CTAATCCTTCAAGCTGAAAAAAACGGTGCCACGGTCAGGAGACACCTGCAAGCCCTCCTGGAAACATCCCACCAGTGGCCCAAGCAGAGG
GAGGGCATGGCTCTGACCTTGGGGCTGGCGGCCACACGCCACCTGGATGACGTCTGGGCCGTCCTGGACCAGTTTGGCAGGAGCAGGCCC
ATCAGATGGAGTCTCCCCAGCTCCTCCCCAAAGAACTCGGAGGACCTGCGCTGGAAATGGGCCAGCAGCACCATCCTCCTGGCATACGGC
CAGGTGGCAGCCAAAGCCCGGGCCCACATCCTCCCGTGGGTGGACAACATCGTGTCCAGGATGGTCTTCTACTTCCACTACAGCTCTTGG
GACGAGACCCTGAAGCAGAGCTTCCTCACAGCCACCCTGATGCTGATGGGTGCGGTGAGCCGGAGTGAGGGCGCCCACAGCTACGAGTTC
TTCCAGACCTCTGAGCTCCTCCAGTGTCTGATGGTTTTGATGGAGAAGGAGCCCCAGGACACTCTGTGCACGCGGAGTCGCCAGCAGGCC
ATGCACATCGCGTCCAGCCTCTGCAAGCTGAGGCCTCCCATAGACTTGGAAAGGAAGTCTCAGCTCCTGTCCACCTGCTTCCGCAGCGTG
TTTGCCCTGCCACTGCTGGATGCCCTGGAGAAGCACACCTGCCTCTTTCTGGAGCCTCCCAACATCCAGCTGTGGCCCGTGGCTCGGGAG
CGGGCAGGCTGGACGCACCAGGGCTGGGGACCCAGGGCAGTTCTTCACTGCTCTGAGCACCTACAGAGCCTGTACAGCAGGACCATGGAG
GCGCTGGACTTCATGCTGCAAAGCCTCATCATGCAGAACCCCACCGCCGACGAGCTGCATTTCCTGCTGTCGCACCTGTACATCTGGCTG
GCGTCGGAGAAGGCGCATGAGCGGCAGCGGGCTGTGCACAGCTGCATGATCCTCCTCAAATTCCTGAACCACAATGGCTACTTGGACCCA
AAAGAGGACTTCAAAAGGATTGGGCAATTGGTGGGCATACTGGGGATGCTGTGCCAGGACCCAGACAGGGCCACCCAGCGCTGCAGCCTG
GAAGGGGCAAGCCATCTCTACCAGCTCTTGATGTGCCACAAAACAGGAGAAGCTTTGCAGGCAGAATCACAGGCCCCCAAGGAGCTCTCC
CAGGCCCATTCGGACGGAGCCCCACTCTGGAACAGCAGAGACCAGAAGGCCACTCCCCTGGGCCCCCAGGAGATGGCAAAGAACCACATC
TTCCAGCTCTGCAGCTTCCAAGTCATCAAGGATATCATGCAGCAGCTCACACTGGCAGAGTTGAGCGACCTCATCTGGACGGCCATCGAC
GGCCTGGGCTCCACCAGCCCCTTCCGCGTGCAGGCAGCCTCCGAGATGCTGCTCACAGCCGTCCAGGAGCACGGGGCCAAGCTGGAGATC
GTTTCCAGCATGGCCCAGGCCATCCGCCTCCGCCTGTGCTCTGTCCACATCCCGCAAGCCAAGGAAAAGACCCTGCACGCCATCACCCTG
CTGGCCCGGAGCCACACCTGTGAGCTGGTGGCCACCTTCCTGAACATCTCCATCCCCTTGGACAGCCACACCTTCCAGCTGTGGAGGGCC
CTGGGGGCTGGGCAGCCCACGAGCCACCTGGTGCTGACCACACTGCTGGCCTGTCTGCAGGAGCGACCCCTGCCCACCGGTGCCAGCGAC
AGCAGCCCCTGCCCCAAGGAGAAGACCTACCTGCGTTTGCTGGCTGCCATGAACATGCTGCACGAGCTGCAGTTTGCCCGGGAGTTCAAG
CAGGCCGTGCAGGAGGGCTACCCCAAGCTCTTCCTGGCCCTCCTCACCCAGATGCACTATGTCTTGGAGCTGAACCTGCCCAGCGAGCCC
TAGCCCAAGCAGCAGGCCCAGGAGGCGGCCGTGCCCAGCCCCCAAAGCTGCAGCACGTCACTGGAGGCACTGAAGAGCCTGCTGTCCACC
ACGGGGCACTGGCATGACTTTGCCCACCTGGAGCTGCAGGGATCCTGGGAGCTCTTCACCACCATCCACACCTACCCGAAGGGCGTGGGC
CTCCTTGCCAGGGCCATGGTGCAGAACCACTGCAGGCAGATCCCAGCGGTGCTGCGTCAGCTGCTGCCCAGCCTGCAGAGCCCACAGGAG
CGTGAGAGGAAGGTGGCCATCCTCATCCTCACCAAGTTCCTCTACAGCCCTGTCCTGCTGGAGGTGCTTCCCAAACAAGCTGCCTTGACC
GTGCTGGCACAAGGCCTCCACGACCCCAGCCCTGAGGTCCGCGTGTTGAGTCTGCAGGGCCTAAGCAACATCCTCTTCCACCCAGATAAG
GGAAGCCTGCTCCAGGGACAGCTGCGGCCCTTGCTCGACGGCTTCTTCCAGAGCAGCGACCAGGTGATCGTGTGCATCATGGGCACCGTG
TCAGACACGCTGCACCGCCTGGGCGCGCAGGGCACAGGGAGTCAGAGCCTCGGCGTTGCCATCAGCACACGCTCCTTCTTTAATGACGAG
CGGGACGGGATTCGGGCGGCAGCCATGGCACTGTTCGGGGACCTGGTGGCGGCCATGGCAGACAGGGAGCTGAGCGGCCTGCGGACCCAG
GTGCACCAGAGCATGGTGCCCCTGCTCCTACACCTGAAGGACCAATGCCCAGCTGTCGCCACGCAGGCCAAGTTCACCTTCTACCGCTGT
GCTGTGCTGCTCCGCTGGCGGCTACTGCACACCCTCTTCTGCACGCTGGCCTGGGAGAGGGGCCTCAGCGCCCGCCACTTCCTCTGGACC
TGCCTGATGACCCGCAGCCAGGAGGAATTCAGCATCCACTTGTCACAGGCCCTCAGCTACCTGCACAGCCACTCCTGCCACATCAAGACC
TGGGTGACACTCTTCATAGGCCACACCATCTGCTACCACCCCCAGGCCGTGTTCCAGATGCTGAATGCTGTGGACACCAACCTGCTGTTC
CGCACTTTTGAACATCTCAGAAGTGACCCTGAGCCCAGCATCCGGGAATTCGCCACCAGCCAGCTCTCCTTCCTCCAGAAGGTGTCGGCC
AGACCCAAGCAGTGACCTCCAGCCATCCTCCCCCACCCACCGCCTTCCCCTCCCGTGTCCACCTGGTCAGCCCTGCCCCATCCGCCCCCC

>70043_70043_5_PTK2-MROH5_PTK2_chr8_141696731_ENST00000538769_MROH5_chr8_142490548_ENST00000430863_length(amino acids)=1196AA_BP=522
MADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERI
ELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQ
VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSA
SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMR
MESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIA
MWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPMAIKSVPFLSTDVWSKEL
LWTLTTPSWTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQWPKQREGMALTLGLAATRHLDDVWAVLDQFGRSRPIRWS
LPSSSPKNSEDLRWKWASSTILLAYGQVAAKARAHILPWVDNIVSRMVFYFHYSSWDETLKQSFLTATLMLMGAVSRSEGAHSYEFFQTS
ELLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPIDLERKSQLLSTCFRSVFALPLLDALEKHTCLFLEPPNIQLWPVARERAGW
THQGWGPRAVLHCSEHLQSLYSRTMEALDFMLQSLIMQNPTADELHFLLSHLYIWLASEKAHERQRAVHSCMILLKFLNHNGYLDPKEDF
KRIGQLVGILGMLCQDPDRATQRCSLEGASHLYQLLMCHKTGEALQAESQAPKELSQAHSDGAPLWNSRDQKATPLGPQEMAKNHIFQLC
SFQVIKDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAASEMLLTAVQEHGAKLEIVSSMAQAIRLRLCSVHIPQAKEKTLHAITLLARS
HTCELVATFLNISIPLDSHTFQLWRALGAGQPTSHLVLTTLLACLQERPLPTGASDSSPCPKEKTYLRLLAAMNMLHELQFAREFKQAVQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTK2-MROH5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTK2chr8:141696731chr8:142490548ENST00000340930-2733912_1052854.01066.0ARHGEF28
HgenePTK2chr8:141696731chr8:142490548ENST00000521059-2732912_1052854.01053.0ARHGEF28
HgenePTK2chr8:141696731chr8:142490548ENST00000522684-2732912_1052854.01053.0ARHGEF28


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTK2-MROH5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTK2-MROH5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource