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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTK2-PHF20L1 (FusionGDB2 ID:70048)

Fusion Gene Summary for PTK2-PHF20L1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK2-PHF20L1
Fusion gene ID: 70048
HgeneTgene
Gene symbol

PTK2

PHF20L1

Gene ID

5747

51105

Gene nameprotein tyrosine kinase 2PHD finger protein 20 like 1
SynonymsFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAKCGI-72|TDRD20B|URLC1
Cytomap

8q24.3

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71PHD finger protein 20-like protein 1tudor domain containing 20Btudor domain-containing protein PHF20L1up-regulated in lung cancer 1
Modification date2020032720200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340930, ENST00000395218, 
ENST00000517887, ENST00000519419, 
ENST00000521059, ENST00000522684, 
ENST00000535192, ENST00000430260, 
ENST00000519465, ENST00000538769, 
ENST00000517712, ENST00000519635, 
ENST00000519881, ENST00000520151, 
ENST00000520892, ENST00000522950, 
ENST00000220847, ENST00000395390, 
ENST00000337920, ENST00000395376, 
ENST00000395379, ENST00000395386, 
Fusion gene scores* DoF score39 X 32 X 15=187208 X 9 X 7=504
# samples 5710
** MAII scorelog2(57/18720*10)=-5.03747470541866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTK2 [Title/Abstract] AND PHF20L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTK2(141684396)-PHF20L1(133858025), # samples:1
PTK2(141874410)-PHF20L1(133836248), # samples:1
Anticipated loss of major functional domain due to fusion event.PTK2-PHF20L1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTK2-PHF20L1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
PTK2-PHF20L1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PTK2-PHF20L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

HgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

HgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

HgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

HgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

HgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

HgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

HgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

HgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across PTK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHF20L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2016PTK2chr8

141684396

-PHF20L1chr8

133858025

+
ChimerDB4STADTCGA-BR-8678PTK2chr8

141874410

-PHF20L1chr8

133836248

+


Top

Fusion Gene ORF analysis for PTK2-PHF20L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340930ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000340930ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000395218ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000395218ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000517887ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000517887ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000519419ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000519419ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000521059ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000521059ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000522684ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000522684ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000535192ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-5UTRENST00000535192ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000340930ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000340930ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000340930ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000340930ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000340930ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000340930ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000340930ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000340930ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000395218ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000395218ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000395218ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000395218ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000395218ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000395218ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000395218ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000395218ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000430260ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000430260ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000430260ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000430260ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000430260ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000517887ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000517887ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000517887ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000517887ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000517887ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000517887ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000517887ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000517887ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519419ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519419ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519419ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000519419ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519419ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000519419ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519419ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000519419ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519465ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519465ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519465ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519465ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000519465ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000521059ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000521059ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000521059ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000521059ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000521059ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000521059ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000521059ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000521059ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000522684ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000522684ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000522684ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000522684ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000522684ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000522684ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000522684ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000522684ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000535192ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000535192ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000535192ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000535192ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000535192ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000535192ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000535192ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
5CDS-intronENST00000535192ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000538769ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000538769ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000538769ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000538769ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
5CDS-intronENST00000538769ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
Frame-shiftENST00000340930ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000395218ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000517887ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
Frame-shiftENST00000517887ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000519419ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000519465ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
Frame-shiftENST00000521059ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
Frame-shiftENST00000521059ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000522684ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000535192ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
Frame-shiftENST00000535192ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
Frame-shiftENST00000538769ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
In-frameENST00000340930ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
In-frameENST00000395218ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
In-frameENST00000430260ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
In-frameENST00000519419ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
In-frameENST00000522684ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000430260ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000517712ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000517712ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000519465ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000519635ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000519635ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000519881ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000519881ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000520151ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000520151ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000520892ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000520892ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000522950ENST00000395386PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-3CDSENST00000522950ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-3CDSENST00000538769ENST00000395386PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000430260ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000430260ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000517712ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000517712ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000519465ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000519465ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000519635ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000519635ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000519881ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000519881ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000520151ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000520151ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000520892ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000520892ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000522950ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000522950ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000538769ENST00000220847PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-5UTRENST00000538769ENST00000395390PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000430260ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000430260ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000430260ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000517712ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000517712ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000517712ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000517712ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000517712ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000517712ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000517712ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000517712ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519465ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519465ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519465ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519635ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519635ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519635ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519635ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519635ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519635ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519635ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519635ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519881ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519881ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519881ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519881ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519881ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519881ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000519881ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000519881ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520151ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520151ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520151ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000520151ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520151ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000520151ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520151ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000520151ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520892ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520892ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520892ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000520892ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520892ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000520892ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000520892ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000520892ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000522950ENST00000220847PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000522950ENST00000337920PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000522950ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000522950ENST00000395376PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000522950ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000522950ENST00000395379PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000522950ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000522950ENST00000395390PTK2chr8

141684396

-PHF20L1chr8

133858025

+
intron-intronENST00000538769ENST00000337920PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000538769ENST00000395376PTK2chr8

141874410

-PHF20L1chr8

133836248

+
intron-intronENST00000538769ENST00000395379PTK2chr8

141874410

-PHF20L1chr8

133836248

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000522684PTK2chr8141684396-ENST00000395386PHF20L1chr8133858025+596629392303022930
ENST00000395218PTK2chr8141684396-ENST00000395386PHF20L1chr8133858025+599629692303052940
ENST00000340930PTK2chr8141684396-ENST00000395386PHF20L1chr8133858025+592128941552977940
ENST00000519419PTK2chr8141684396-ENST00000395386PHF20L1chr8133858025+618031532703236988
ENST00000430260PTK2chr8141684396-ENST00000395386PHF20L1chr8133858025+412410974251180251

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000522684ENST00000395386PTK2chr8141684396-PHF20L1chr8133858025+0.0001939640.9998061
ENST00000395218ENST00000395386PTK2chr8141684396-PHF20L1chr8133858025+0.0001865890.9998134
ENST00000340930ENST00000395386PTK2chr8141684396-PHF20L1chr8133858025+0.00018920.9998109
ENST00000519419ENST00000395386PTK2chr8141684396-PHF20L1chr8133858025+0.0001805790.99981946
ENST00000430260ENST00000395386PTK2chr8141684396-PHF20L1chr8133858025+0.0025463470.99745363

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Fusion Genomic Features for PTK2-PHF20L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTK2chr8141874410-PHF20L1chr8133836248+0.0001758920.9998241
PTK2chr8141684396-PHF20L1chr8133858025+5.95E-050.9999405
PTK2chr8141874410-PHF20L1chr8133836248+0.0001758920.9998241
PTK2chr8141684396-PHF20L1chr8133858025+5.95E-050.9999405

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTK2-PHF20L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141684396/chr8:133858025)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-2933712_7339131066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-2933863_9139131066.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-2932712_7339031053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-2932712_7339031053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-293335_3559131066.0DomainFERM
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-2933422_6809131066.0DomainProtein kinase
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-293235_3559031053.0DomainFERM
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-2932422_6809031053.0DomainProtein kinase
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-293235_3559031053.0DomainFERM
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-2932422_6809031053.0DomainProtein kinase
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-2933428_4349131066.0Nucleotide bindingATP
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-2933500_5029131066.0Nucleotide bindingATP
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-2932428_4349031053.0Nucleotide bindingATP
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-2932500_5029031053.0Nucleotide bindingATP
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-2932428_4349031053.0Nucleotide bindingATP
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-2932500_5029031053.0Nucleotide bindingATP
TgenePHF20L1chr8:141684396chr8:133858025ENST000002208471820530_579357405.0Compositional biasNote=Lys-rich
TgenePHF20L1chr8:141684396chr8:133858025ENST0000033792008530_5790286.0Compositional biasNote=Lys-rich
TgenePHF20L1chr8:141684396chr8:133858025ENST000003379200811_710286.0DomainNote=Tudor 1
TgenePHF20L1chr8:141684396chr8:133858025ENST000003379200885_1410286.0DomainNote=Tudor 2
TgenePHF20L1chr8:141684396chr8:133858025ENST000002208471820681_729357405.0Zinc fingerNote=PHD-type
TgenePHF20L1chr8:141684396chr8:133858025ENST0000033792008681_7290286.0Zinc fingerNote=PHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-2932863_9139031053.0Compositional biasNote=Pro-rich
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-2932863_9139031053.0Compositional biasNote=Pro-rich
TgenePHF20L1chr8:141684396chr8:133858025ENST000003953861921530_5799701018.0Compositional biasNote=Lys-rich
TgenePHF20L1chr8:141684396chr8:133858025ENST00000220847182011_71357405.0DomainNote=Tudor 1
TgenePHF20L1chr8:141684396chr8:133858025ENST00000220847182085_141357405.0DomainNote=Tudor 2
TgenePHF20L1chr8:141684396chr8:133858025ENST00000395386192111_719701018.0DomainNote=Tudor 1
TgenePHF20L1chr8:141684396chr8:133858025ENST00000395386192185_1419701018.0DomainNote=Tudor 2
TgenePHF20L1chr8:141684396chr8:133858025ENST000003953861921681_7299701018.0Zinc fingerNote=PHD-type


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Fusion Gene Sequence for PTK2-PHF20L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70048_70048_1_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000340930_PHF20L1_chr8_133858025_ENST00000395386_length(transcript)=5921nt_BP=2894nt
TGCCTTCGCTTCACGGCGCCGAGCCGCGGTCCGAGCAGAACTGGGGCTCCCTTGCATCTTCCAGTTACAAATTCAGTGCCTTCTGCAGTT
TCCCCAGAGCTCCTCAAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCA
ACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGG
TCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTC
AGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTC
ACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATT
TGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGA
TAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAG
AAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAA
CACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTC
CAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAG
GAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAG
ACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGA
ATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGG
CTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTG
AGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTG
GAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACT
GTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAG
TCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGG
ATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTG
CTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAG
CTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTG
GTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGG
AAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGT
TTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGG
CCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGAT
TTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCA
GCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGG
AGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAA
TGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATG
GAAGTCTTCAGGGTCCGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGGTAAAGAAGAAAAGAATTGGGCGGAAAGAAATC
CTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACA
ACGAGGGTGTCAAGTTCTGGAAAGCTGGCTTGATTTCACAGGGGAGTTGGAGCCACCAGATCCTCTTGCAAGATTGCCCCAACTTAAACG
CCACATAAAACAGCTCCTAATTGACATGGGCAAAGTACAGCAGATAGCAACTCTTTGCTCTGTATGACAACAGTGAACACTTAATGAAAG
AATGTGGCTTTCTTCAGTCAAAGCATTTTTATTATCCACGTGATGGCTAAGTGGATAATTTAAAAGCTTAGTAATGTCTGGTCATTCACT
GATTTGTGATGTCAATAGGATGGCACCTTGGAAAGAAAAATGAAGAACAACTTTATCAAGGAAGCTAGTATTTAAAAACAAATTCATGAG
CAAGCTGCAAATGAGAATGTGTTATATGCCAAGGAACAATGAAGTAGAATATAATGTATACTAAGGGATTTCAAGTTCTCAGAATTTTTG
AGTAGTTGCTTACGTGAAGCTCAAGATACCTGTAGAAAGAAATATGGTATATTTGTATAGTTTTTAATAGAAAGATCTATGTTTATAAAC
CAGCACTTGGCCAAAAACAAAATTGTAAAGGAAATTTAAATTCTGGAGAATTCTACAGGGTTGCTCTAAGAACTGTCTTCTCAGCAGTTG
ATCCAGCTGTACGGAAATTTAGGGTATTTAAACTTTTAAAGGATCATGAGCTGTTTCTTGGGCGATGAATGTTCTCAATCAGAAAACTGA
CAGTAGAAATCTCACTTCTGGGGAAAACAGTTGTGGAATTCTTACTTCATTATGAATGTATTTAAAAAACAAACACCAAATAATTGGAAT
ATATTGCAGGCATTAAGCTCATTAAAAACAAACTGGCTTGCAGAAGGGTCCGATGTGCCAAGTGATCATGATTCTGCTGGAAAGAGGATT
TTAAATATTGTGGGAGTTCTCCCACCCTAAGTCTTACATAATGCCACCAGTCCATCCAAAACCTATATATCACCTATACTATATATATCA
TATATATAGTTGAATGGCAGTATTCAGGCTCAACGTACAGTTTGATCCTGAGTATGCTTGGTGTTTGCCTTCAGAAAAAAAAAAATACAT
TGTAAATAACCTCAGCTGGGATGAGGAGTGACAGAATATCAAAATAATTTGTGGCTGTGGATTTTTTTAACTGCTAGTAGTGGAATACTG
GAAAAGCTTCATTTCTGAAGATGAATTTTATTTTTAAAAAATACATGCACACTCAAAACTTTTAGCTTTGATCACAAGTGGACAAATTTC
TGAAACCAAAGGCAACTAAGTTGCTGTGTTAGCTCTTGCTGGATTTTGAGCCTAGGTCCTACTGTCTGCCAGTACTCATGTGAGTTGTAT
GTGCCCCCAGTGCTACATACGCAGGTATGCGTAAGTGTGTATGCTTGTTTTAAACAAACACTCAACGTACATATGTACATAATCTACACA
TATTTATATCACATATCTAGTTTTATTACTATAGACTATACGAATTGGTGGTTAACATGAAATGTTACCTTTTAACAGACTGTTTTTAAA
AATTAAAAATGTATGTATAGGTTTTGAAATTTTTTTAAAAGGGGAGAAAGACTGTTAAGAGGAGGCTATTTGATGACATAACACTTGAAT
ATTTTATGCCTCATTCTGTTTATCAGTTCTCGCAATCTGTATAAATGCATTTTAGAACTGATAGACAGTAAACTTGAATTTATCTTTGAT
AAGAATACATGCCACTGTACATTCAGATATTATTTAAATTTGCAAACACATTGTTCTATATGTAAGGGTACTGTATGTAAAACTCTGTAT
TAAAACTATTCCACATATCCTAAAATTTCAGCTTGCCTTTTTGCGGCCTTATATTTTGATGTAAAGATTAAAAGAATGTGCAAAACAGTC
AGAAATTTTTATTGCCTTTTGAGATTCTCCAACTTGACAAATGTGCCAAAGATCAACAGACAGAAAATATCATCCTGTGTATTTACTTGT
CATACTTTAACTTTGTGAAAGATCTTACTGATAAATGAAAAGCTTTAGCAGAGGTGGTATTGTGGGGTAATTGCTTAAATTTACATATCA
AAGTAAAAAAGTAGTGCCTGTATTCCATGTGTGGAGTAAATTTGCTAATGTCTATATTTTATGATTGATACTATTATTTTTCCTTTGCAT
TTTAAAATAGTGGCTCTAATATTTTCCCTGTCATGGCTACATTCTAGACATTGAATTTATATCTTCTTTTTTTCAGATACGGAGCAAATA
GCATCCTTAACCTATGAATAATGGTGTTGCCTAGATTCTTGTCACACACACAGAAGACCCTTTGTACCTAGTAACATTCATCCTCTTGAT
TCCTGGTGAACACGGTTAAATTCATGCACATTTGTTCTTGTAGTTTCTAAAAATTAGATCAATTTATTTGTTAGCCAGCAAATTGAAAAT
TCCATTATTAGATTAATGAAATTTTTGCTCTGCTTATATGTATACGAACTGGAAATCTGAATTTTTAAATTTAGATCTTTAAATCAAATT
ATTTTTATGCATATTTTCATTTAATATAGAGTATACCAATCGATTGAAGCCTTTCACAAGTAGTGCGCTGAGCTTTTCTTATTGAAGAGA
GTGAATTAGTTTCTGAGAAGTCAGTCTATTGTGAAAAGTTTCAGATGAGATTATTTTCTTTTAGTCTTTTTAAATATCACTATATGTATT
TAAATAGAAGCAATAAACTAGAGAGAGTGTTTCTTGAAAAGACAATGTTTTATTTGCCACCAGGCAGAACAGAATGAGCATTGGTAGAGA
AGGCTCCCTCTTGGTATGTTACTGATAAACTTGTACTTCCTCATACTTGTTTGTGGTTCTACTGACTTATTTCCAAACTTAAGAGTAATG
TACTTCGAAAACAACTTGGTTATTCTTTAAATTTCAGGTAAAACCCCTTTTCCTAACACTCATCTTATTTCCACTGTCTTATTTCCTCTC

>70048_70048_1_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000340930_PHF20L1_chr8_133858025_ENST00000395386_length(amino acids)=940AA_BP=913
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND
VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEE
RLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPGKEEKNWAERNPAAPPKKPPRPGAPGHLGSLAS

--------------------------------------------------------------
>70048_70048_2_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000395218_PHF20L1_chr8_133858025_ENST00000395386_length(transcript)=5996nt_BP=2969nt
GACCACTGTGAGCCCGCGGCGTGAGGCGTGGGAGGAAGCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACG
GCGCCGAGCCGCGGTCCGAGCAGAACTGGGGCTCCCTTGCATCTTCCAGTTACAAATTCAGTGCCTTCTGCAGTTTCCCCAGAGCTCCTC
AAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACAC
CAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTG
AAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACA
GTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCG
TCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTC
TAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGG
ACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACT
ATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGA
TCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTG
ATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAA
CGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAG
GAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAA
TAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATAC
CAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAG
AAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTG
GAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCG
TGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATC
CTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGA
TCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGG
TGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAAT
TGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGG
AGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGC
CTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAG
CTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGG
ACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCAC
AGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTC
AGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTAT
TGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGC
GCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTC
CGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGGTAAAGAAGAAAAGAATTGGGCGGAAAGAAATCCTGCAGCTCCACCAA
AGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGT
TCTGGAAAGCTGGCTTGATTTCACAGGGGAGTTGGAGCCACCAGATCCTCTTGCAAGATTGCCCCAACTTAAACGCCACATAAAACAGCT
CCTAATTGACATGGGCAAAGTACAGCAGATAGCAACTCTTTGCTCTGTATGACAACAGTGAACACTTAATGAAAGAATGTGGCTTTCTTC
AGTCAAAGCATTTTTATTATCCACGTGATGGCTAAGTGGATAATTTAAAAGCTTAGTAATGTCTGGTCATTCACTGATTTGTGATGTCAA
TAGGATGGCACCTTGGAAAGAAAAATGAAGAACAACTTTATCAAGGAAGCTAGTATTTAAAAACAAATTCATGAGCAAGCTGCAAATGAG
AATGTGTTATATGCCAAGGAACAATGAAGTAGAATATAATGTATACTAAGGGATTTCAAGTTCTCAGAATTTTTGAGTAGTTGCTTACGT
GAAGCTCAAGATACCTGTAGAAAGAAATATGGTATATTTGTATAGTTTTTAATAGAAAGATCTATGTTTATAAACCAGCACTTGGCCAAA
AACAAAATTGTAAAGGAAATTTAAATTCTGGAGAATTCTACAGGGTTGCTCTAAGAACTGTCTTCTCAGCAGTTGATCCAGCTGTACGGA
AATTTAGGGTATTTAAACTTTTAAAGGATCATGAGCTGTTTCTTGGGCGATGAATGTTCTCAATCAGAAAACTGACAGTAGAAATCTCAC
TTCTGGGGAAAACAGTTGTGGAATTCTTACTTCATTATGAATGTATTTAAAAAACAAACACCAAATAATTGGAATATATTGCAGGCATTA
AGCTCATTAAAAACAAACTGGCTTGCAGAAGGGTCCGATGTGCCAAGTGATCATGATTCTGCTGGAAAGAGGATTTTAAATATTGTGGGA
GTTCTCCCACCCTAAGTCTTACATAATGCCACCAGTCCATCCAAAACCTATATATCACCTATACTATATATATCATATATATAGTTGAAT
GGCAGTATTCAGGCTCAACGTACAGTTTGATCCTGAGTATGCTTGGTGTTTGCCTTCAGAAAAAAAAAAATACATTGTAAATAACCTCAG
CTGGGATGAGGAGTGACAGAATATCAAAATAATTTGTGGCTGTGGATTTTTTTAACTGCTAGTAGTGGAATACTGGAAAAGCTTCATTTC
TGAAGATGAATTTTATTTTTAAAAAATACATGCACACTCAAAACTTTTAGCTTTGATCACAAGTGGACAAATTTCTGAAACCAAAGGCAA
CTAAGTTGCTGTGTTAGCTCTTGCTGGATTTTGAGCCTAGGTCCTACTGTCTGCCAGTACTCATGTGAGTTGTATGTGCCCCCAGTGCTA
CATACGCAGGTATGCGTAAGTGTGTATGCTTGTTTTAAACAAACACTCAACGTACATATGTACATAATCTACACATATTTATATCACATA
TCTAGTTTTATTACTATAGACTATACGAATTGGTGGTTAACATGAAATGTTACCTTTTAACAGACTGTTTTTAAAAATTAAAAATGTATG
TATAGGTTTTGAAATTTTTTTAAAAGGGGAGAAAGACTGTTAAGAGGAGGCTATTTGATGACATAACACTTGAATATTTTATGCCTCATT
CTGTTTATCAGTTCTCGCAATCTGTATAAATGCATTTTAGAACTGATAGACAGTAAACTTGAATTTATCTTTGATAAGAATACATGCCAC
TGTACATTCAGATATTATTTAAATTTGCAAACACATTGTTCTATATGTAAGGGTACTGTATGTAAAACTCTGTATTAAAACTATTCCACA
TATCCTAAAATTTCAGCTTGCCTTTTTGCGGCCTTATATTTTGATGTAAAGATTAAAAGAATGTGCAAAACAGTCAGAAATTTTTATTGC
CTTTTGAGATTCTCCAACTTGACAAATGTGCCAAAGATCAACAGACAGAAAATATCATCCTGTGTATTTACTTGTCATACTTTAACTTTG
TGAAAGATCTTACTGATAAATGAAAAGCTTTAGCAGAGGTGGTATTGTGGGGTAATTGCTTAAATTTACATATCAAAGTAAAAAAGTAGT
GCCTGTATTCCATGTGTGGAGTAAATTTGCTAATGTCTATATTTTATGATTGATACTATTATTTTTCCTTTGCATTTTAAAATAGTGGCT
CTAATATTTTCCCTGTCATGGCTACATTCTAGACATTGAATTTATATCTTCTTTTTTTCAGATACGGAGCAAATAGCATCCTTAACCTAT
GAATAATGGTGTTGCCTAGATTCTTGTCACACACACAGAAGACCCTTTGTACCTAGTAACATTCATCCTCTTGATTCCTGGTGAACACGG
TTAAATTCATGCACATTTGTTCTTGTAGTTTCTAAAAATTAGATCAATTTATTTGTTAGCCAGCAAATTGAAAATTCCATTATTAGATTA
ATGAAATTTTTGCTCTGCTTATATGTATACGAACTGGAAATCTGAATTTTTAAATTTAGATCTTTAAATCAAATTATTTTTATGCATATT
TTCATTTAATATAGAGTATACCAATCGATTGAAGCCTTTCACAAGTAGTGCGCTGAGCTTTTCTTATTGAAGAGAGTGAATTAGTTTCTG
AGAAGTCAGTCTATTGTGAAAAGTTTCAGATGAGATTATTTTCTTTTAGTCTTTTTAAATATCACTATATGTATTTAAATAGAAGCAATA
AACTAGAGAGAGTGTTTCTTGAAAAGACAATGTTTTATTTGCCACCAGGCAGAACAGAATGAGCATTGGTAGAGAAGGCTCCCTCTTGGT
ATGTTACTGATAAACTTGTACTTCCTCATACTTGTTTGTGGTTCTACTGACTTATTTCCAAACTTAAGAGTAATGTACTTCGAAAACAAC
TTGGTTATTCTTTAAATTTCAGGTAAAACCCCTTTTCCTAACACTCATCTTATTTCCACTGTCTTATTTCCTCTCAGATGTTCATATTTC

>70048_70048_2_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000395218_PHF20L1_chr8_133858025_ENST00000395386_length(amino acids)=940AA_BP=913
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND
VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEE
RLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPGKEEKNWAERNPAAPPKKPPRPGAPGHLGSLAS

--------------------------------------------------------------
>70048_70048_3_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000430260_PHF20L1_chr8_133858025_ENST00000395386_length(transcript)=4124nt_BP=1097nt
AACAGCACATTCTAGCCTCCAGCCAAGCAGGAATGTCTTTTTAAACAGTTGAGCAAATTCCCAGATTAGAAAGTCTGGTGCACTGATGTC
ACTCTTTCCTGAGTAATTTTTGGGTGGTTGTTTACTGCACACTATCTACCAGGAGCCTAGAAACTTTGAATGAGTGTCATTATTAGAACT
CTAGAGTTGTAGGAATGTAGGAAGAGCTGTTTGCCACAGTTAGGACGAGGGTTTCAAACTGTCTGCTGAGCCCTGGGGCATCTGCGTGGA
ATGGGAAACTAGCAAAGTCTCGCTTTGGCTGCATTCTGAGGGGTTTATGTGATGGCAAACAGCCAAGATGAAGAAGCTGCCTAGCAGTCG
CTGCAGCGGCTGCAGCGTTATGTGGGACTTCAGATAGCTTCTGAGTAGTCAAGCAGTGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAG
AAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGAC
CGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACC
CTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGAC
CTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGA
TGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGA
GACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAG
ATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCT
ACAACGAGGGTGTCAAGTTCTGGAAAGCTGGCTTGATTTCACAGGGGAGTTGGAGCCACCAGATCCTCTTGCAAGATTGCCCCAACTTAA
ACGCCACATAAAACAGCTCCTAATTGACATGGGCAAAGTACAGCAGATAGCAACTCTTTGCTCTGTATGACAACAGTGAACACTTAATGA
AAGAATGTGGCTTTCTTCAGTCAAAGCATTTTTATTATCCACGTGATGGCTAAGTGGATAATTTAAAAGCTTAGTAATGTCTGGTCATTC
ACTGATTTGTGATGTCAATAGGATGGCACCTTGGAAAGAAAAATGAAGAACAACTTTATCAAGGAAGCTAGTATTTAAAAACAAATTCAT
GAGCAAGCTGCAAATGAGAATGTGTTATATGCCAAGGAACAATGAAGTAGAATATAATGTATACTAAGGGATTTCAAGTTCTCAGAATTT
TTGAGTAGTTGCTTACGTGAAGCTCAAGATACCTGTAGAAAGAAATATGGTATATTTGTATAGTTTTTAATAGAAAGATCTATGTTTATA
AACCAGCACTTGGCCAAAAACAAAATTGTAAAGGAAATTTAAATTCTGGAGAATTCTACAGGGTTGCTCTAAGAACTGTCTTCTCAGCAG
TTGATCCAGCTGTACGGAAATTTAGGGTATTTAAACTTTTAAAGGATCATGAGCTGTTTCTTGGGCGATGAATGTTCTCAATCAGAAAAC
TGACAGTAGAAATCTCACTTCTGGGGAAAACAGTTGTGGAATTCTTACTTCATTATGAATGTATTTAAAAAACAAACACCAAATAATTGG
AATATATTGCAGGCATTAAGCTCATTAAAAACAAACTGGCTTGCAGAAGGGTCCGATGTGCCAAGTGATCATGATTCTGCTGGAAAGAGG
ATTTTAAATATTGTGGGAGTTCTCCCACCCTAAGTCTTACATAATGCCACCAGTCCATCCAAAACCTATATATCACCTATACTATATATA
TCATATATATAGTTGAATGGCAGTATTCAGGCTCAACGTACAGTTTGATCCTGAGTATGCTTGGTGTTTGCCTTCAGAAAAAAAAAAATA
CATTGTAAATAACCTCAGCTGGGATGAGGAGTGACAGAATATCAAAATAATTTGTGGCTGTGGATTTTTTTAACTGCTAGTAGTGGAATA
CTGGAAAAGCTTCATTTCTGAAGATGAATTTTATTTTTAAAAAATACATGCACACTCAAAACTTTTAGCTTTGATCACAAGTGGACAAAT
TTCTGAAACCAAAGGCAACTAAGTTGCTGTGTTAGCTCTTGCTGGATTTTGAGCCTAGGTCCTACTGTCTGCCAGTACTCATGTGAGTTG
TATGTGCCCCCAGTGCTACATACGCAGGTATGCGTAAGTGTGTATGCTTGTTTTAAACAAACACTCAACGTACATATGTACATAATCTAC
ACATATTTATATCACATATCTAGTTTTATTACTATAGACTATACGAATTGGTGGTTAACATGAAATGTTACCTTTTAACAGACTGTTTTT
AAAAATTAAAAATGTATGTATAGGTTTTGAAATTTTTTTAAAAGGGGAGAAAGACTGTTAAGAGGAGGCTATTTGATGACATAACACTTG
AATATTTTATGCCTCATTCTGTTTATCAGTTCTCGCAATCTGTATAAATGCATTTTAGAACTGATAGACAGTAAACTTGAATTTATCTTT
GATAAGAATACATGCCACTGTACATTCAGATATTATTTAAATTTGCAAACACATTGTTCTATATGTAAGGGTACTGTATGTAAAACTCTG
TATTAAAACTATTCCACATATCCTAAAATTTCAGCTTGCCTTTTTGCGGCCTTATATTTTGATGTAAAGATTAAAAGAATGTGCAAAACA
GTCAGAAATTTTTATTGCCTTTTGAGATTCTCCAACTTGACAAATGTGCCAAAGATCAACAGACAGAAAATATCATCCTGTGTATTTACT
TGTCATACTTTAACTTTGTGAAAGATCTTACTGATAAATGAAAAGCTTTAGCAGAGGTGGTATTGTGGGGTAATTGCTTAAATTTACATA
TCAAAGTAAAAAAGTAGTGCCTGTATTCCATGTGTGGAGTAAATTTGCTAATGTCTATATTTTATGATTGATACTATTATTTTTCCTTTG
CATTTTAAAATAGTGGCTCTAATATTTTCCCTGTCATGGCTACATTCTAGACATTGAATTTATATCTTCTTTTTTTCAGATACGGAGCAA
ATAGCATCCTTAACCTATGAATAATGGTGTTGCCTAGATTCTTGTCACACACACAGAAGACCCTTTGTACCTAGTAACATTCATCCTCTT
GATTCCTGGTGAACACGGTTAAATTCATGCACATTTGTTCTTGTAGTTTCTAAAAATTAGATCAATTTATTTGTTAGCCAGCAAATTGAA
AATTCCATTATTAGATTAATGAAATTTTTGCTCTGCTTATATGTATACGAACTGGAAATCTGAATTTTTAAATTTAGATCTTTAAATCAA
ATTATTTTTATGCATATTTTCATTTAATATAGAGTATACCAATCGATTGAAGCCTTTCACAAGTAGTGCGCTGAGCTTTTCTTATTGAAG
AGAGTGAATTAGTTTCTGAGAAGTCAGTCTATTGTGAAAAGTTTCAGATGAGATTATTTTCTTTTAGTCTTTTTAAATATCACTATATGT
ATTTAAATAGAAGCAATAAACTAGAGAGAGTGTTTCTTGAAAAGACAATGTTTTATTTGCCACCAGGCAGAACAGAATGAGCATTGGTAG
AGAAGGCTCCCTCTTGGTATGTTACTGATAAACTTGTACTTCCTCATACTTGTTTGTGGTTCTACTGACTTATTTCCAAACTTAAGAGTA
ATGTACTTCGAAAACAACTTGGTTATTCTTTAAATTTCAGGTAAAACCCCTTTTCCTAACACTCATCTTATTTCCACTGTCTTATTTCCT

>70048_70048_3_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000430260_PHF20L1_chr8_133858025_ENST00000395386_length(amino acids)=251AA_BP=224
MEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLD
QTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQH

--------------------------------------------------------------
>70048_70048_4_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000519419_PHF20L1_chr8_133858025_ENST00000395386_length(transcript)=6180nt_BP=3153nt
TCTCTGACTGCAATGGAAAGAGGAAAGAGAAATTAGAAGTATTTTTTTAAATTGTCATTTGATTTCTTCAGAGTTATTGTGGGCTTCTGA
ACTATTGCGGAAGCATGAGAAGATTCTGTAACTGAGAGGCATTCTTCAAGCTGCTGGAAAATATTACAGAAGGAACACCTTCCAAATTTT
GCTTCAAGCTCTGAAAAAAGGAGCACACAGGGGAACCTTAGTCTTGCTTGTGGATCGAAGCAAATACTATCACAGCGAGGAACTGGGACT
TTGTGTGCAGACTCCTGGCTTGATCTTTATAGGATTGGGTGTATGTTGTTGGAACTGGCAGGCCAAGAGGCCCTGAAACCAGCAGGTGCC
ATCTATATGGAGAAAAGCGGATGTAGTCCATTTCCAGTGTGTTGGGCTAAAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCA
GCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCA
ATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACT
GATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCA
GAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATAT
GAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAG
AGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAG
ATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTG
GATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAA
TTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTG
GCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATT
CAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCA
TCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCT
CAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCA
GAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATA
GAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCA
ATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCAT
ATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAA
GTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTT
GTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAA
GATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCT
AGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATC
GGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGAC
CCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGG
ATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGT
CCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGA
ATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCA
ATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTA
ATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGC
AGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCA
CCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTC
AAGTTCTGGAAAGCTGGCTTGATTTCACAGGGGAGTTGGAGCCACCAGATCCTCTTGCAAGATTGCCCCAACTTAAACGCCACATAAAAC
AGCTCCTAATTGACATGGGCAAAGTACAGCAGATAGCAACTCTTTGCTCTGTATGACAACAGTGAACACTTAATGAAAGAATGTGGCTTT
CTTCAGTCAAAGCATTTTTATTATCCACGTGATGGCTAAGTGGATAATTTAAAAGCTTAGTAATGTCTGGTCATTCACTGATTTGTGATG
TCAATAGGATGGCACCTTGGAAAGAAAAATGAAGAACAACTTTATCAAGGAAGCTAGTATTTAAAAACAAATTCATGAGCAAGCTGCAAA
TGAGAATGTGTTATATGCCAAGGAACAATGAAGTAGAATATAATGTATACTAAGGGATTTCAAGTTCTCAGAATTTTTGAGTAGTTGCTT
ACGTGAAGCTCAAGATACCTGTAGAAAGAAATATGGTATATTTGTATAGTTTTTAATAGAAAGATCTATGTTTATAAACCAGCACTTGGC
CAAAAACAAAATTGTAAAGGAAATTTAAATTCTGGAGAATTCTACAGGGTTGCTCTAAGAACTGTCTTCTCAGCAGTTGATCCAGCTGTA
CGGAAATTTAGGGTATTTAAACTTTTAAAGGATCATGAGCTGTTTCTTGGGCGATGAATGTTCTCAATCAGAAAACTGACAGTAGAAATC
TCACTTCTGGGGAAAACAGTTGTGGAATTCTTACTTCATTATGAATGTATTTAAAAAACAAACACCAAATAATTGGAATATATTGCAGGC
ATTAAGCTCATTAAAAACAAACTGGCTTGCAGAAGGGTCCGATGTGCCAAGTGATCATGATTCTGCTGGAAAGAGGATTTTAAATATTGT
GGGAGTTCTCCCACCCTAAGTCTTACATAATGCCACCAGTCCATCCAAAACCTATATATCACCTATACTATATATATCATATATATAGTT
GAATGGCAGTATTCAGGCTCAACGTACAGTTTGATCCTGAGTATGCTTGGTGTTTGCCTTCAGAAAAAAAAAAATACATTGTAAATAACC
TCAGCTGGGATGAGGAGTGACAGAATATCAAAATAATTTGTGGCTGTGGATTTTTTTAACTGCTAGTAGTGGAATACTGGAAAAGCTTCA
TTTCTGAAGATGAATTTTATTTTTAAAAAATACATGCACACTCAAAACTTTTAGCTTTGATCACAAGTGGACAAATTTCTGAAACCAAAG
GCAACTAAGTTGCTGTGTTAGCTCTTGCTGGATTTTGAGCCTAGGTCCTACTGTCTGCCAGTACTCATGTGAGTTGTATGTGCCCCCAGT
GCTACATACGCAGGTATGCGTAAGTGTGTATGCTTGTTTTAAACAAACACTCAACGTACATATGTACATAATCTACACATATTTATATCA
CATATCTAGTTTTATTACTATAGACTATACGAATTGGTGGTTAACATGAAATGTTACCTTTTAACAGACTGTTTTTAAAAATTAAAAATG
TATGTATAGGTTTTGAAATTTTTTTAAAAGGGGAGAAAGACTGTTAAGAGGAGGCTATTTGATGACATAACACTTGAATATTTTATGCCT
CATTCTGTTTATCAGTTCTCGCAATCTGTATAAATGCATTTTAGAACTGATAGACAGTAAACTTGAATTTATCTTTGATAAGAATACATG
CCACTGTACATTCAGATATTATTTAAATTTGCAAACACATTGTTCTATATGTAAGGGTACTGTATGTAAAACTCTGTATTAAAACTATTC
CACATATCCTAAAATTTCAGCTTGCCTTTTTGCGGCCTTATATTTTGATGTAAAGATTAAAAGAATGTGCAAAACAGTCAGAAATTTTTA
TTGCCTTTTGAGATTCTCCAACTTGACAAATGTGCCAAAGATCAACAGACAGAAAATATCATCCTGTGTATTTACTTGTCATACTTTAAC
TTTGTGAAAGATCTTACTGATAAATGAAAAGCTTTAGCAGAGGTGGTATTGTGGGGTAATTGCTTAAATTTACATATCAAAGTAAAAAAG
TAGTGCCTGTATTCCATGTGTGGAGTAAATTTGCTAATGTCTATATTTTATGATTGATACTATTATTTTTCCTTTGCATTTTAAAATAGT
GGCTCTAATATTTTCCCTGTCATGGCTACATTCTAGACATTGAATTTATATCTTCTTTTTTTCAGATACGGAGCAAATAGCATCCTTAAC
CTATGAATAATGGTGTTGCCTAGATTCTTGTCACACACACAGAAGACCCTTTGTACCTAGTAACATTCATCCTCTTGATTCCTGGTGAAC
ACGGTTAAATTCATGCACATTTGTTCTTGTAGTTTCTAAAAATTAGATCAATTTATTTGTTAGCCAGCAAATTGAAAATTCCATTATTAG
ATTAATGAAATTTTTGCTCTGCTTATATGTATACGAACTGGAAATCTGAATTTTTAAATTTAGATCTTTAAATCAAATTATTTTTATGCA
TATTTTCATTTAATATAGAGTATACCAATCGATTGAAGCCTTTCACAAGTAGTGCGCTGAGCTTTTCTTATTGAAGAGAGTGAATTAGTT
TCTGAGAAGTCAGTCTATTGTGAAAAGTTTCAGATGAGATTATTTTCTTTTAGTCTTTTTAAATATCACTATATGTATTTAAATAGAAGC
AATAAACTAGAGAGAGTGTTTCTTGAAAAGACAATGTTTTATTTGCCACCAGGCAGAACAGAATGAGCATTGGTAGAGAAGGCTCCCTCT
TGGTATGTTACTGATAAACTTGTACTTCCTCATACTTGTTTGTGGTTCTACTGACTTATTTCCAAACTTAAGAGTAATGTACTTCGAAAA
CAACTTGGTTATTCTTTAAATTTCAGGTAAAACCCCTTTTCCTAACACTCATCTTATTTCCACTGTCTTATTTCCTCTCAGATGTTCATA

>70048_70048_4_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000519419_PHF20L1_chr8_133858025_ENST00000395386_length(amino acids)=988AA_BP=961
MCADSWLDLYRIGCMLLELAGQEALKPAGAIYMEKSGCSPFPVCWAKEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA
MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKY
ELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLL
DSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTI
QYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS
ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH
IVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME
DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD
PSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHG
ITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRG

--------------------------------------------------------------
>70048_70048_5_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000522684_PHF20L1_chr8_133858025_ENST00000395386_length(transcript)=5966nt_BP=2939nt
GACCACTGTGAGCCCGCGGCGTGAGGCGTGGGAGGAAGCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACG
GCGCCGAGCCGCGGTCCGAGCAGAACTGGGGCTCCCTTGCATCTTCCAGTTACAAATTCAGTGCCTTCTGCAGTTTCCCCAGAGCTCCTC
AAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACAC
CAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTG
AAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACA
GTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCG
TCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTC
TAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGG
ACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACT
ATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGA
TCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTG
ATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAA
CGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAG
GAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAA
TAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATAC
CAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAG
AAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTG
GAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCG
TGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATC
CTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGA
TCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGG
TGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAAT
TGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGG
AGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGC
CTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAG
CTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGG
ACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCAC
AGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTC
AGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTAT
TGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGC
GCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTC
CGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTC
ATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGTTCTGGAAAGCTGGCTTGATTTCACAGGGGA
GTTGGAGCCACCAGATCCTCTTGCAAGATTGCCCCAACTTAAACGCCACATAAAACAGCTCCTAATTGACATGGGCAAAGTACAGCAGAT
AGCAACTCTTTGCTCTGTATGACAACAGTGAACACTTAATGAAAGAATGTGGCTTTCTTCAGTCAAAGCATTTTTATTATCCACGTGATG
GCTAAGTGGATAATTTAAAAGCTTAGTAATGTCTGGTCATTCACTGATTTGTGATGTCAATAGGATGGCACCTTGGAAAGAAAAATGAAG
AACAACTTTATCAAGGAAGCTAGTATTTAAAAACAAATTCATGAGCAAGCTGCAAATGAGAATGTGTTATATGCCAAGGAACAATGAAGT
AGAATATAATGTATACTAAGGGATTTCAAGTTCTCAGAATTTTTGAGTAGTTGCTTACGTGAAGCTCAAGATACCTGTAGAAAGAAATAT
GGTATATTTGTATAGTTTTTAATAGAAAGATCTATGTTTATAAACCAGCACTTGGCCAAAAACAAAATTGTAAAGGAAATTTAAATTCTG
GAGAATTCTACAGGGTTGCTCTAAGAACTGTCTTCTCAGCAGTTGATCCAGCTGTACGGAAATTTAGGGTATTTAAACTTTTAAAGGATC
ATGAGCTGTTTCTTGGGCGATGAATGTTCTCAATCAGAAAACTGACAGTAGAAATCTCACTTCTGGGGAAAACAGTTGTGGAATTCTTAC
TTCATTATGAATGTATTTAAAAAACAAACACCAAATAATTGGAATATATTGCAGGCATTAAGCTCATTAAAAACAAACTGGCTTGCAGAA
GGGTCCGATGTGCCAAGTGATCATGATTCTGCTGGAAAGAGGATTTTAAATATTGTGGGAGTTCTCCCACCCTAAGTCTTACATAATGCC
ACCAGTCCATCCAAAACCTATATATCACCTATACTATATATATCATATATATAGTTGAATGGCAGTATTCAGGCTCAACGTACAGTTTGA
TCCTGAGTATGCTTGGTGTTTGCCTTCAGAAAAAAAAAAATACATTGTAAATAACCTCAGCTGGGATGAGGAGTGACAGAATATCAAAAT
AATTTGTGGCTGTGGATTTTTTTAACTGCTAGTAGTGGAATACTGGAAAAGCTTCATTTCTGAAGATGAATTTTATTTTTAAAAAATACA
TGCACACTCAAAACTTTTAGCTTTGATCACAAGTGGACAAATTTCTGAAACCAAAGGCAACTAAGTTGCTGTGTTAGCTCTTGCTGGATT
TTGAGCCTAGGTCCTACTGTCTGCCAGTACTCATGTGAGTTGTATGTGCCCCCAGTGCTACATACGCAGGTATGCGTAAGTGTGTATGCT
TGTTTTAAACAAACACTCAACGTACATATGTACATAATCTACACATATTTATATCACATATCTAGTTTTATTACTATAGACTATACGAAT
TGGTGGTTAACATGAAATGTTACCTTTTAACAGACTGTTTTTAAAAATTAAAAATGTATGTATAGGTTTTGAAATTTTTTTAAAAGGGGA
GAAAGACTGTTAAGAGGAGGCTATTTGATGACATAACACTTGAATATTTTATGCCTCATTCTGTTTATCAGTTCTCGCAATCTGTATAAA
TGCATTTTAGAACTGATAGACAGTAAACTTGAATTTATCTTTGATAAGAATACATGCCACTGTACATTCAGATATTATTTAAATTTGCAA
ACACATTGTTCTATATGTAAGGGTACTGTATGTAAAACTCTGTATTAAAACTATTCCACATATCCTAAAATTTCAGCTTGCCTTTTTGCG
GCCTTATATTTTGATGTAAAGATTAAAAGAATGTGCAAAACAGTCAGAAATTTTTATTGCCTTTTGAGATTCTCCAACTTGACAAATGTG
CCAAAGATCAACAGACAGAAAATATCATCCTGTGTATTTACTTGTCATACTTTAACTTTGTGAAAGATCTTACTGATAAATGAAAAGCTT
TAGCAGAGGTGGTATTGTGGGGTAATTGCTTAAATTTACATATCAAAGTAAAAAAGTAGTGCCTGTATTCCATGTGTGGAGTAAATTTGC
TAATGTCTATATTTTATGATTGATACTATTATTTTTCCTTTGCATTTTAAAATAGTGGCTCTAATATTTTCCCTGTCATGGCTACATTCT
AGACATTGAATTTATATCTTCTTTTTTTCAGATACGGAGCAAATAGCATCCTTAACCTATGAATAATGGTGTTGCCTAGATTCTTGTCAC
ACACACAGAAGACCCTTTGTACCTAGTAACATTCATCCTCTTGATTCCTGGTGAACACGGTTAAATTCATGCACATTTGTTCTTGTAGTT
TCTAAAAATTAGATCAATTTATTTGTTAGCCAGCAAATTGAAAATTCCATTATTAGATTAATGAAATTTTTGCTCTGCTTATATGTATAC
GAACTGGAAATCTGAATTTTTAAATTTAGATCTTTAAATCAAATTATTTTTATGCATATTTTCATTTAATATAGAGTATACCAATCGATT
GAAGCCTTTCACAAGTAGTGCGCTGAGCTTTTCTTATTGAAGAGAGTGAATTAGTTTCTGAGAAGTCAGTCTATTGTGAAAAGTTTCAGA
TGAGATTATTTTCTTTTAGTCTTTTTAAATATCACTATATGTATTTAAATAGAAGCAATAAACTAGAGAGAGTGTTTCTTGAAAAGACAA
TGTTTTATTTGCCACCAGGCAGAACAGAATGAGCATTGGTAGAGAAGGCTCCCTCTTGGTATGTTACTGATAAACTTGTACTTCCTCATA
CTTGTTTGTGGTTCTACTGACTTATTTCCAAACTTAAGAGTAATGTACTTCGAAAACAACTTGGTTATTCTTTAAATTTCAGGTAAAACC
CCTTTTCCTAACACTCATCTTATTTCCACTGTCTTATTTCCTCTCAGATGTTCATATTTCACATGTTCAAAATGAAGCGTACTATTTCCC

>70048_70048_5_PTK2-PHF20L1_PTK2_chr8_141684396_ENST00000522684_PHF20L1_chr8_133858025_ENST00000395386_length(amino acids)=930AA_BP=903
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL
RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV
ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND
VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEE
RLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTK2-PHF20L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTK2chr8:141684396chr8:133858025ENST00000340930-2933912_1052913.01066.0ARHGEF28
HgenePTK2chr8:141684396chr8:133858025ENST00000521059-2932912_1052903.01053.0ARHGEF28
HgenePTK2chr8:141684396chr8:133858025ENST00000522684-2932912_1052903.01053.0ARHGEF28


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTK2-PHF20L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTK2-PHF20L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource