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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PTK2-RNF139 (FusionGDB2 ID:70052) |
Fusion Gene Summary for PTK2-RNF139 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTK2-RNF139 | Fusion gene ID: 70052 | Hgene | Tgene | Gene symbol | PTK2 | RNF139 | Gene ID | 5747 | 11236 |
| Gene name | protein tyrosine kinase 2 | ring finger protein 139 | |
| Synonyms | FADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK | HRCA1|RCA1|TRC8 | |
| Cytomap | 8q24.3 | 8q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71 | E3 ubiquitin-protein ligase RNF139RING-type E3 ubiquitin transferase RNF139multiple membrane spanning receptor TRC8patched related protein translocated in renal cancertranslocation in renal carcinoma on chromosome 8 proteintranslocation in renal carc | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000340930, ENST00000395218, ENST00000430260, ENST00000519419, ENST00000522684, ENST00000517887, ENST00000519465, ENST00000521059, ENST00000535192, ENST00000538769, ENST00000517712, ENST00000519635, ENST00000519881, ENST00000520151, ENST00000520892, ENST00000522950, | ENST00000303545, | |
| Fusion gene scores | * DoF score | 39 X 32 X 15=18720 | 4 X 3 X 4=48 |
| # samples | 57 | 5 | |
| ** MAII score | log2(57/18720*10)=-5.03747470541866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PTK2 [Title/Abstract] AND RNF139 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PTK2(141696731)-RNF139(125498072), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | PTK2-RNF139 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PTK2-RNF139 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. PTK2-RNF139 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTK2 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 24036928 |
| Hgene | PTK2 | GO:0007229 | integrin-mediated signaling pathway | 24036928 |
| Hgene | PTK2 | GO:0010763 | positive regulation of fibroblast migration | 26763945 |
| Hgene | PTK2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 10655584|11331870 |
| Hgene | PTK2 | GO:0022408 | negative regulation of cell-cell adhesion | 21703394 |
| Hgene | PTK2 | GO:0030335 | positive regulation of cell migration | 11331870|21703394 |
| Hgene | PTK2 | GO:0033628 | regulation of cell adhesion mediated by integrin | 10655584 |
| Hgene | PTK2 | GO:0046777 | protein autophosphorylation | 10655584|11331870 |
| Hgene | PTK2 | GO:0048013 | ephrin receptor signaling pathway | 10655584 |
| Hgene | PTK2 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
| Hgene | PTK2 | GO:0090303 | positive regulation of wound healing | 26763945 |
| Tgene | RNF139 | GO:0008285 | negative regulation of cell proliferation | 17016439 |
| Tgene | RNF139 | GO:0016567 | protein ubiquitination | 10500182|17016439 |
| Tgene | RNF139 | GO:0017148 | negative regulation of translation | 20068067 |
| Tgene | RNF139 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport | 19706601 |
| Tgene | RNF139 | GO:0070613 | regulation of protein processing | 19706601 |
| Fusion gene breakpoints across PTK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RNF139 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-86-8359-01A | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| ChimerDB4 | LUAD | TCGA-86-8359-01A | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
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Fusion Gene ORF analysis for PTK2-RNF139 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000340930 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000340930 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000395218 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000395218 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000430260 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000430260 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000519419 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000519419 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000522684 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| Frame-shift | ENST00000522684 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000517887 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000517887 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000519465 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000519465 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000521059 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000521059 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000535192 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000535192 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000538769 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| In-frame | ENST00000538769 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000517712 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000517712 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000519635 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000519635 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000519881 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000519881 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000520151 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000520151 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000520892 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000520892 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000522950 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + |
| intron-3CDS | ENST00000522950 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000535192 | PTK2 | chr8 | 141696731 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 4539 | 2455 | 31 | 2481 | 816 |
| ENST00000519465 | PTK2 | chr8 | 141696731 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 3702 | 1618 | 1641 | 3431 | 596 |
| ENST00000517887 | PTK2 | chr8 | 141696731 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 5084 | 3000 | 264 | 3026 | 920 |
| ENST00000521059 | PTK2 | chr8 | 141696731 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 4828 | 2744 | 101 | 2770 | 889 |
| ENST00000538769 | PTK2 | chr8 | 141696731 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 3662 | 1578 | 1601 | 3391 | 596 |
| ENST00000535192 | PTK2 | chr8 | 141710990 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 4476 | 2392 | 31 | 2418 | 795 |
| ENST00000519465 | PTK2 | chr8 | 141710990 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 3639 | 1555 | 1527 | 3368 | 613 |
| ENST00000517887 | PTK2 | chr8 | 141710990 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 5021 | 2937 | 264 | 2963 | 899 |
| ENST00000521059 | PTK2 | chr8 | 141710990 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 4765 | 2681 | 101 | 2707 | 868 |
| ENST00000538769 | PTK2 | chr8 | 141710990 | - | ENST00000303545 | RNF139 | chr8 | 125498072 | + | 3599 | 1515 | 1487 | 3328 | 613 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000535192 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + | 0.000330115 | 0.9996699 |
| ENST00000519465 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + | 0.00033535 | 0.99966466 |
| ENST00000517887 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + | 0.00021956 | 0.9997805 |
| ENST00000521059 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + | 0.000288109 | 0.9997118 |
| ENST00000538769 | ENST00000303545 | PTK2 | chr8 | 141696731 | - | RNF139 | chr8 | 125498072 | + | 0.000420806 | 0.99957925 |
| ENST00000535192 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + | 0.000333698 | 0.99966633 |
| ENST00000519465 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + | 0.000332411 | 0.99966764 |
| ENST00000517887 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + | 0.000263115 | 0.99973685 |
| ENST00000521059 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + | 0.000317348 | 0.99968266 |
| ENST00000538769 | ENST00000303545 | PTK2 | chr8 | 141710990 | - | RNF139 | chr8 | 125498072 | + | 0.000420642 | 0.99957937 |
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Fusion Genomic Features for PTK2-RNF139 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PTK2 | chr8 | 141696730 | - | RNF139 | chr8 | 125498071 | + | 0.00018084 | 0.9998192 |
| PTK2 | chr8 | 141710989 | - | RNF139 | chr8 | 125498071 | + | 1.81E-06 | 0.9999982 |
| PTK2 | chr8 | 141696730 | - | RNF139 | chr8 | 125498071 | + | 0.00018084 | 0.9998192 |
| PTK2 | chr8 | 141710989 | - | RNF139 | chr8 | 125498071 | + | 1.81E-06 | 0.9999982 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PTK2-RNF139 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141696731/chr8:125498072) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 712_733 | 854 | 1066.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 712_733 | 854 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 712_733 | 854 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 712_733 | 833 | 1066.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 712_733 | 833 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 712_733 | 833 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 35_355 | 854 | 1066.0 | Domain | FERM |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 422_680 | 854 | 1066.0 | Domain | Protein kinase |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 35_355 | 854 | 1053.0 | Domain | FERM |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 422_680 | 854 | 1053.0 | Domain | Protein kinase |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 35_355 | 854 | 1053.0 | Domain | FERM |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 422_680 | 854 | 1053.0 | Domain | Protein kinase |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 35_355 | 833 | 1066.0 | Domain | FERM |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 422_680 | 833 | 1066.0 | Domain | Protein kinase |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 35_355 | 833 | 1053.0 | Domain | FERM |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 422_680 | 833 | 1053.0 | Domain | Protein kinase |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 35_355 | 833 | 1053.0 | Domain | FERM |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 422_680 | 833 | 1053.0 | Domain | Protein kinase |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 428_434 | 854 | 1066.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 500_502 | 854 | 1066.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 428_434 | 854 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 500_502 | 854 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 428_434 | 854 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 500_502 | 854 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 428_434 | 833 | 1066.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 500_502 | 833 | 1066.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 428_434 | 833 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 500_502 | 833 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 428_434 | 833 | 1053.0 | Nucleotide binding | ATP |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 500_502 | 833 | 1053.0 | Nucleotide binding | ATP |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 125_145 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 154_174 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 178_198 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 293_313 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 323_343 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 356_376 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 390_410 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 420_440 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 469_489 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 495_512 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 85_105 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 125_145 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 154_174 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 178_198 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 293_313 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 323_343 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 356_376 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 390_410 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 420_440 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 469_489 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 495_512 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 85_105 | 60 | 665.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 863_913 | 854 | 1066.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 863_913 | 854 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 863_913 | 854 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 863_913 | 833 | 1066.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 863_913 | 833 | 1053.0 | Compositional bias | Note=Pro-rich |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 863_913 | 833 | 1053.0 | Compositional bias | Note=Pro-rich |
| Tgene | RNF139 | chr8:141696731 | chr8:125498072 | ENST00000303545 | 0 | 2 | 51_71 | 60 | 665.0 | Transmembrane | Helical | |
| Tgene | RNF139 | chr8:141710990 | chr8:125498072 | ENST00000303545 | 0 | 2 | 51_71 | 60 | 665.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for PTK2-RNF139 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >70052_70052_1_PTK2-RNF139_PTK2_chr8_141696731_ENST00000517887_RNF139_chr8_125498072_ENST00000303545_length(transcript)=5084nt_BP=3000nt TAGGAACACAGAGCCATGGGGTCACATTACTAAGCTGGTTTCATTCTGTTCAGTAGCTTGATCTAGCCAGGATGGTCTGTGTTTCAGATT GCGGAAGCATGAGAAGATTCTGTAACTGAGAGGCATTCTTCAAGCTGCTGGAAAATATTACAGAAGGAACACCTTCCAAATTTTGCTTCA AGCTCTGAAAAAAGGAGCACACAGGGGAACCTTAGTCTTGCTTGTGGATCGAAGCAAATACTATCACAGCGAGGAACTGGGACTTTGTGT GCAGACTCCTGGCTTGATCTTTATAGGATTGGGTGTATGTTGTTGGAACTGGCAGGCCAAGAGGCCCTGAAACCAGCAGGTGCCATCTAT ATGGAGAAAAGCGGATGTAGTCCATTTCCAGTGTGTTGGGCTAAAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCT TACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAG CGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTC AGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAG GTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTG AGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGAT TATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGG GGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCT GTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTT GAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATC GGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTAT TCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTA ACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAA GAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACA GATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTT GGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAA ACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTG AAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGG AAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACAC AGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGT ACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGAC GTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGA ATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGC AGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAG TCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGG TCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACA GCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGG CAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGA CAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATT GACAGGGAGGATGGAAGTCTTCAGGGTCCGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTACA CGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACA CGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGAT ACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTAC CATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGGT TTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTACAGTTATTGATGGAGGACACATGGAAGA GGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCAA ATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAATTAGTGGGTGCGATTCTACACTAACTG TACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGACA GGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTAAGACCAGAAGAGAGACTTATTC GCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCCT CTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCTGTCTTACTCAGTTATGTTCTTT GGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTTT ATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCTACTACGTTCGTTCAACAGGCAGTATTA TTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATGT GCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATCGTAGGACTGCTGTGAAGAAAATTAATT CACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATTA CACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTTGTCCAATGTGCCATCAGAAAGTATACA TCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAAG CTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTCAAAGAGAAAGAAATGGAGTGATTCAGC ACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAATGATTGAGGTATTTGTTTAAAATTCAG TTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCAATGTTGAATCTGTGAATGGTTTTCCGT TTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAATTTGTGTACATTATTGTACATA >70052_70052_1_PTK2-RNF139_PTK2_chr8_141696731_ENST00000517887_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=920AA_BP= MCADSWLDLYRIGCMLLELAGQEALKPAGAIYMEKSGCSPFPVCWAKEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKY ELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLL DSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTI QYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH IVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD PSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHG ITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRG -------------------------------------------------------------- >70052_70052_2_PTK2-RNF139_PTK2_chr8_141696731_ENST00000519465_RNF139_chr8_125498072_ENST00000303545_length(transcript)=3702nt_BP=1618nt AGCCCTGTTTGCTCTCCGATAAACAAGTCTGTGTATTATAACGTATTGGACAATGATGTCACTTTTATTTCCATAAATGACTCATGTGTG AGCAAAATTTGAGTAATAGTGTTTTAAGAATATTTCAGCGTAGTAGAGGATTTAAGCAGATCGCTTTGCCTACTTTAATTATATGAAATA CCAGGAGGTCAGATGTTTAACCTCTTTCAACATATCTGTTTCTTTTCCTGCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGA TACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGA TGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAG AGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGT CTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCT GTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTC CTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCC TATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGAT ACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCC AAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCA GCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTC CGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCA CATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGC ATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGA CCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTG GCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGGT GTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACT TCAGTGTTGGTGAATTATTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGA AAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTAT TCACAATTAATTATTTTGGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACT TCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTG GTGAGGCACATGTATCGAATTTACGGATTACAGTTATTGATGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTT TGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGAT GATTTTTGGGACCTCATTTGCAATCTTATAATTAGTGGGTGCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTA GCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTT TTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTAAGACCAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACT GCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCT GTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCTGTCTTACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTT GCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAAT GTCCTCTGGGAAAAGCTTGACGATTATGTCTACTACGTTCGTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGA AATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAA GCCAAAAATGGCTGGAAGACATTTATGAATCGTAGGACTGCTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAA GAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGC CTTCGGAAATGGCTGTACATTCAAGATACTTGTCCAATGTGCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTA TCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAA GATGACAGTACAGATTGTGATGATGATGTTCAAAGAGAAAGAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGAT GATACTGACTGATGAAAATAGCATTTATTAATGATTGAGGTATTTGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTT CAGTGTGTAACCAAGCACAAAAACAGTATCAATGTTGAATCTGTGAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCT TTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAATTTGTGTACATTATTGTACATAGAATAAAATGTTTTCACATTTTTATGACAAAA >70052_70052_2_PTK2-RNF139_PTK2_chr8_141696731_ENST00000519465_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=596AA_BP= MILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILD LLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTA QATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQT GLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCV ELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNIYLQAKNGWKT FMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFI -------------------------------------------------------------- >70052_70052_3_PTK2-RNF139_PTK2_chr8_141696731_ENST00000521059_RNF139_chr8_125498072_ENST00000303545_length(transcript)=4828nt_BP=2744nt GCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACGGCGCCGAGCCGCGGTCCGAAGTCTTGCTGTGTCACCC AGGCTGCCAGGCTGGAGTGGAGTGGCATGATCTCGGCTGACTGCAACCTCTGCCTCCCAGAATATGACAGATACCTAGCATCTAGCAAAA TAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTC CTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAG ATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACC TGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGT GGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAAC AGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCAT ACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGA GTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTA TTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAG TGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGC AAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGA CGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCA TCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCT CTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAG AAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGG CGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACC ATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCAT TTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCA AAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGAT ATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTA CCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATG ATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGG CCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGC GCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTT ATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTT CACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGG AGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAG AGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCT CTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATCACT TTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGCACATTGACTTCTA TGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCTAAC ATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTCCTGTAATAGGCTT AATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGCAGT GAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTACAGTTATTGATGGA GGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGTACAT CTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAATTAGTGGGTGCGA TTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGATCAAC TGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTAAGACCAGA AGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTATTAAT GTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCTGTCTTACT CAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAATTGT TTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCTACTACGTTCGTTC AACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAATTCG GGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATCGTAGGACTGCTGT GAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTACAAC ATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTTGTCCAATGTGCCA TCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAGAGGA AGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTCAAAGAGAAAGAAA TGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAATGATTGAGGTATT TGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCAATGTTGAATCTGT GAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAATTTGTGTA >70052_70052_3_PTK2-RNF139_PTK2_chr8_141696731_ENST00000521059_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=889AA_BP= MEWSGMISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATD VRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKS DYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKF FEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPS LTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIE LGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRM ESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAM -------------------------------------------------------------- >70052_70052_4_PTK2-RNF139_PTK2_chr8_141696731_ENST00000535192_RNF139_chr8_125498072_ENST00000303545_length(transcript)=4539nt_BP=2455nt ATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGAC TCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAAC CACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGT GGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAA GTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGA TAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAA GTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGA TGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACA ATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTG TGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCC CACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAAT AGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCT GGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGA AAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCC CTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCAT TTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCA AGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGA GCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCT TAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGT AAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGC TCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGT GAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTAC CCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCT GGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGA AGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAA TCATTACCAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCA ACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAG GGAGGATGGAAGTCTTCAGGGTCCGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTACACGTAC AGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACACGTCA GCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGATACGTT ACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTACCATTA CACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGGTTTTAT TATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTACAGTTATTGATGGAGGACACATGGAAGAGGATT CGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCAAATGAA ACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAATTAGTGGGTGCGATTCTACACTAACTGTACTG GGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGACAGGCGT CTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTAAGACCAGAAGAGAGACTTATTCGCTTA AGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCCTCTCAT GTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCTGTCTTACTCAGTTATGTTCTTTGGCAT CACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTTTATACG TTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCTACTACGTTCGTTCAACAGGCAGTATTATTGAA TTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATGTGCCTA CATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATCGTAGGACTGCTGTGAAGAAAATTAATTCACTT CCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATTACACCG TGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTTGTCCAATGTGCCATCAGAAAGTATACATCGAA GATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAAGCTGCT GCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTCAAAGAGAAAGAAATGGAGTGATTCAGCACACA GGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAATGATTGAGGTATTTGTTTAAAATTCAGTTCAT CCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCAATGTTGAATCTGTGAATGGTTTTCCGTTTACT GTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAATTTGTGTACATTATTGTACATAGAATA >70052_70052_4_PTK2-RNF139_PTK2_chr8_141696731_ENST00000535192_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=816AA_BP= MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY PSPRSSEGFYPSPQHMVQTNHYQDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPVY -------------------------------------------------------------- >70052_70052_5_PTK2-RNF139_PTK2_chr8_141696731_ENST00000538769_RNF139_chr8_125498072_ENST00000303545_length(transcript)=3662nt_BP=1578nt ATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAA GGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGAT GATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAAAAAGCTATGGAATAGATGAAGCCAGGGATTATGAGATTCAA AGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCT TTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTT GACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGG TCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAG AGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCC CGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGT TTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAAC AATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGC TGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAA GAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCG GGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCT GGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCT CAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATG GAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGA CTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGAT CACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGCACATTGACT TCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGC TAACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTCCTGTAATAG GCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGG CAGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTACAGTTATTGA TGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGT ACATCTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAATTAGTGGGT GCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGAT CAACTGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTAAGAC CAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTAT TAATGTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCTGTCT TACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAA TTGTTTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCTACTACGTTC GTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAA TTCGGGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATCGTAGGACTG CTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTA CAACATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTTGTCCAATGT GCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAG AGGAAGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTCAAAGAGAAA GAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAATGATTGAGG TATTTGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCAATGTTGAAT CTGTGAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAATTTG >70052_70052_5_PTK2-RNF139_PTK2_chr8_141696731_ENST00000538769_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=596AA_BP= MILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILD LLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTA QATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQT GLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCV ELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNIYLQAKNGWKT FMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFI -------------------------------------------------------------- >70052_70052_6_PTK2-RNF139_PTK2_chr8_141710990_ENST00000517887_RNF139_chr8_125498072_ENST00000303545_length(transcript)=5021nt_BP=2937nt TAGGAACACAGAGCCATGGGGTCACATTACTAAGCTGGTTTCATTCTGTTCAGTAGCTTGATCTAGCCAGGATGGTCTGTGTTTCAGATT GCGGAAGCATGAGAAGATTCTGTAACTGAGAGGCATTCTTCAAGCTGCTGGAAAATATTACAGAAGGAACACCTTCCAAATTTTGCTTCA AGCTCTGAAAAAAGGAGCACACAGGGGAACCTTAGTCTTGCTTGTGGATCGAAGCAAATACTATCACAGCGAGGAACTGGGACTTTGTGT GCAGACTCCTGGCTTGATCTTTATAGGATTGGGTGTATGTTGTTGGAACTGGCAGGCCAAGAGGCCCTGAAACCAGCAGGTGCCATCTAT ATGGAGAAAAGCGGATGTAGTCCATTTCCAGTGTGTTGGGCTAAAGAATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCT TACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAG CGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTC AGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAG GTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTG AGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGAT TATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGG GGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCT GTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTT GAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATC GGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTAT TCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTA ACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAA GAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACA GATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTT GGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAA ACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTG AAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGG AAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACAC AGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGT ACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGAC GTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGA ATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGC AGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAG TCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGG TCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACA GCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGG CAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGA CAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGGTGTATTTGCATCCAGTATTGTTCTGATCTTGT CACAACGATCACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGC ACATTGACTTCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCG TTCTACAGCTAACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTC CTGTAATAGGCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGT TTGTCCTGGCAGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTAC AGTTATTGATGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAG TGTTAATGTACATCTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAA TTAGTGGGTGCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCT TTATTGGATCAACTGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTG GGCTAAGACCAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAG ACCCTGTATTAATGTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTC TTCCTGTCTTACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCT TAAAAGTAATTGTTTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCT ACTACGTTCGTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGG GAAGTAAAATTCGGGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATC GTAGGACTGCTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATC ATGAGTTTACAACATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTT GTCCAATGTGCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATG AAACTCCAGAGGAAGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTC AAAGAGAAAGAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAA TGATTGAGGTATTTGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCA ATGTTGAATCTGTGAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGT >70052_70052_6_PTK2-RNF139_PTK2_chr8_141710990_ENST00000517887_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=899AA_BP= MCADSWLDLYRIGCMLLELAGQEALKPAGAIYMEKSGCSPFPVCWAKEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGA MERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKY ELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLL DSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTI QYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH IVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD PSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHG -------------------------------------------------------------- >70052_70052_7_PTK2-RNF139_PTK2_chr8_141710990_ENST00000519465_RNF139_chr8_125498072_ENST00000303545_length(transcript)=3639nt_BP=1555nt AGCCCTGTTTGCTCTCCGATAAACAAGTCTGTGTATTATAACGTATTGGACAATGATGTCACTTTTATTTCCATAAATGACTCATGTGTG AGCAAAATTTGAGTAATAGTGTTTTAAGAATATTTCAGCGTAGTAGAGGATTTAAGCAGATCGCTTTGCCTACTTTAATTATATGAAATA CCAGGAGGTCAGATGTTTAACCTCTTTCAACATATCTGTTTCTTTTCCTGCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGA TACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGA TGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAG AGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGT CTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCT GTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTC CTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCC TATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGAT ACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCC AAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCA GCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTC CGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCA CATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGC ATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGA CCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTG GCTGGAAAAAGAGGAAAGATTTCTGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTACACGTAC AGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACACGTCA GCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGATACGTT ACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTACCATTA CACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGGTTTTAT TATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTACAGTTATTGATGGAGGACACATGGAAGAGGATT CGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCAAATGAA ACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAATTAGTGGGTGCGATTCTACACTAACTGTACTG GGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGACAGGCGT CTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTAAGACCAGAAGAGAGACTTATTCGCTTA AGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCCTCTCAT GTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCTGTCTTACTCAGTTATGTTCTTTGGCAT CACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTTTATACG TTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCTACTACGTTCGTTCAACAGGCAGTATTATTGAA TTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATGTGCCTA CATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATCGTAGGACTGCTGTGAAGAAAATTAATTCACTT CCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATTACACCG TGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTTGTCCAATGTGCCATCAGAAAGTATACATCGAA GATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAAGCTGCT GCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTCAAAGAGAAAGAAATGGAGTGATTCAGCACACA GGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAATGATTGAGGTATTTGTTTAAAATTCAGTTCAT CCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCAATGTTGAATCTGTGAATGGTTTTCCGTTTACT GTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAATTTGTGTACATTATTGTACATAGAATA >70052_70052_7_PTK2-RNF139_PTK2_chr8_141710990_ENST00000519465_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=613AA_BP=9 MAGKRGKISGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGY VTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKR IRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDR RLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLW HHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMC LHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYI -------------------------------------------------------------- >70052_70052_8_PTK2-RNF139_PTK2_chr8_141710990_ENST00000521059_RNF139_chr8_125498072_ENST00000303545_length(transcript)=4765nt_BP=2681nt GCGCGGCTGCTGTCGCCCAGCGCCGCCCCGTCGTCGTCTGCCTTCGCTTCACGGCGCCGAGCCGCGGTCCGAAGTCTTGCTGTGTCACCC AGGCTGCCAGGCTGGAGTGGAGTGGCATGATCTCGGCTGACTGCAACCTCTGCCTCCCAGAATATGACAGATACCTAGCATCTAGCAAAA TAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTC CTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAG ATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACC TGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGT GGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAAC AGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCAT ACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGA GTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTA TTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAG TGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGC AAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGA CGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCA TCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCT CTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAG AAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGG CGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACC ATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCAT TTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCA AAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGAT ATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTA CCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATG ATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGG CCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGC GCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTT ATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTT CACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGG AGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAG AGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGGTGTATTTGCATCCAGTAT TGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTA TTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTG GATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTT GGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCAC ATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCG AATTTACGGATTACAGTTATTGATGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTAC AGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCAT TTGCAATCTTATAATTAGTGGGTGCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCT TGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCA GACTGGGTTAAGTGGGCTAAGACCAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTAT CCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGC TTGCCTGTTTATTCTTCCTGTCTTACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTG TGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCT TGACGATTATGTCTACTACGTTCGTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTAT GATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAA GACATTTATGAATCGTAGGACTGCTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATG TGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTA CATTCAAGATACTTGTCCAATGTGCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATT TATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTG TGATGATGATGTTCAAAGAGAAAGAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAA ATAGCATTTATTAATGATTGAGGTATTTGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCA CAAAAACAGTATCAATGTTGAATCTGTGAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCT >70052_70052_8_PTK2-RNF139_PTK2_chr8_141710990_ENST00000521059_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=868AA_BP= MEWSGMISADCNLCLPEYDRYLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATD VRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKS DYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKF FEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPS LTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIE LGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRM ESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAM -------------------------------------------------------------- >70052_70052_9_PTK2-RNF139_PTK2_chr8_141710990_ENST00000535192_RNF139_chr8_125498072_ENST00000303545_length(transcript)=4476nt_BP=2392nt ATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGAC TCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAAC CACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGT GGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAA GTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGA TAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAA GTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGA TGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACA ATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTG TGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAATCC CACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGAATGCTACAACTAAAAAT AGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCT GGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGA AAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCC CTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCAT TTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCA AGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGA GCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCT TAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGT AAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGC TCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGT GAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTAC CCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCT GGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGA AGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAA TCATTACCAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCA ACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGGTGTATTTGCATCCAGTATTGTTCTGATCTTGTCACAA CGATCACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGAATTATTATGCTTCTTTGCACATT GACTTCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGCTGTGGATGGCACTTATCGTTCTA CAGCTAACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTATTTTGGATCTCTTGGTTCCTGTA ATAGGCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTCTCACATTAAATACAGTGTTTGTC CTGGCAGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGTATCGAATTTACGGATTACAGTTA TTGATGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAGTTACAGCTCAGGCTACAGTGTTA ATGTACATCTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACCTCATTTGCAATCTTATAATTAGT GGGTGCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGGGGCTTGGAATATTGGCCTTTATT GGATCAACTGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTCTTCAGACTGGGTTAAGTGGGCTA AGACCAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATTTTATCCATGGAATGACAGACCCT GTATTAATGTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCTCTGCTTGCCTGTTTATTCTTCCT GTCTTACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCATTTTGTGTGGAACTGTGCTTAAAA GTAATTGTTTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAAAGCTTGACGATTATGTCTACTAC GTTCGTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACACTATGATGTTTGAGTCGGGAAGT AAAATTCGGGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCTGGAAGACATTTATGAATCGTAGG ACTGCTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATGTATGTGCAATCTGCTATCATGAG TTTACAACATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGCTGTACATTCAAGATACTTGTCCA ATGTGCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATGGATTTATTCCACCCAATGAAACT CCAGAGGAAGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAGATTGTGATGATGATGTTCAAAGA GAAAGAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGATGAAAATAGCATTTATTAATGATT GAGGTATTTGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCAAGCACAAAAACAGTATCAATGTT GAATCTGTGAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTGGTCTCTTTGGTGACCTGTTTAAA >70052_70052_9_PTK2-RNF139_PTK2_chr8_141710990_ENST00000535192_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=795AA_BP= MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHL RSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISV ELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY -------------------------------------------------------------- >70052_70052_10_PTK2-RNF139_PTK2_chr8_141710990_ENST00000538769_RNF139_chr8_125498072_ENST00000303545_length(transcript)=3599nt_BP=1515nt ATTGCGGAGAATATGGCTGACCTAATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAA GGTGAACGGGCTTTGCCATCAATACCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGAT GATTATGCTGAGATTATAGATGAAGAAGATACTTACACCATGCCCTCAAAAAGCTATGGAATAGATGAAGCCAGGGATTATGAGATTCAA AGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCT TTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTT GACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGG TCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAG AGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCC CGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGT TTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAAC AATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGC TGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAA GAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCG GGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCT GGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCT CAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATG GAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGGTGTATTTGCATCCA GTATTGTTCTGATCTTGTCACAACGATCACTTTTCAAGTTTTACACGTACAGCTCAGCCTTTCTGTTAGCTGCAACTTCAGTGTTGGTGA ATTATTATGCTTCTTTGCACATTGACTTCTATGGTGCCTACAACACGTCAGCTTTTGGAATTGAGCTGCTTCCTCGAAAAGGTCCCTCGC TGTGGATGGCACTTATCGTTCTACAGCTAACATTTGGAATTGGATACGTTACACTACTCCAGATTCATTCCATCTATTCACAATTAATTA TTTTGGATCTCTTGGTTCCTGTAATAGGCTTAATCACAGAGCTACCATTACACATCAGAGAGACTTTACTGTTTACTTCTTCCTTGATTC TCACATTAAATACAGTGTTTGTCCTGGCAGTGAAACTGAAGTGGTTTTATTATTCCACACGATATGTTTATCTTTTGGTGAGGCACATGT ATCGAATTTACGGATTACAGTTATTGATGGAGGACACATGGAAGAGGATTCGTTTCCCAGACATACTACGAGTCTTTTGGCTAACAAGAG TTACAGCTCAGGCTACAGTGTTAATGTACATCTTAAGGATGGCAAATGAAACTGATTCCTTCTTTATTTCTTGGGATGATTTTTGGGACC TCATTTGCAATCTTATAATTAGTGGGTGCGATTCTACACTAACTGTACTGGGCATGAGTGCTGTAATTTCCTCAGTAGCCCATTATTTGG GGCTTGGAATATTGGCCTTTATTGGATCAACTGAGGAAGATGACAGGCGTCTTGGCTTTGTTGCACCTGTTTTATTTTTTATTTTGGCTC TTCAGACTGGGTTAAGTGGGCTAAGACCAGAAGAGAGACTTATTCGCTTAAGTAGAAACATGTGCCTTTTATTAACTGCAGTCCTGCATT TTATCCATGGAATGACAGACCCTGTATTAATGTCTCTCAGTGCCTCTCATGTGTCATCTTTTCGTAGACATTTTCCTGTGCTGTTTGTCT CTGCTTGCCTGTTTATTCTTCCTGTCTTACTCAGTTATGTTCTTTGGCATCACTATGCACTAAATACATGGTTGTTTGCAGTTACAGCAT TTTGTGTGGAACTGTGCTTAAAAGTAATTGTTTCTCTCACTGTTTATACGTTATTCATGATTGATGGCTACTATAATGTCCTCTGGGAAA AGCTTGACGATTATGTCTACTACGTTCGTTCAACAGGCAGTATTATTGAATTTATATTTGGAGTTGTAATGTTTGGAAATGGGGCTTACA CTATGATGTTTGAGTCGGGAAGTAAAATTCGGGCTTTTATGATGTGCCTACATGCATATTTTAACATCTACTTACAAGCCAAAAATGGCT GGAAGACATTTATGAATCGTAGGACTGCTGTGAAGAAAATTAATTCACTTCCTGAAATAAAAGGGAGCCGCTTACAAGAAATAAATGATG TATGTGCAATCTGCTATCATGAGTTTACAACATCTGCTCGTATTACACCGTGTAATCATTATTTCCATGCACTTTGCCTTCGGAAATGGC TGTACATTCAAGATACTTGTCCAATGTGCCATCAGAAAGTATACATCGAAGATGATATCAAGGATAATTCAAATGTATCTAACAACAATG GATTTATTCCACCCAATGAAACTCCAGAGGAAGCTGTAAGAGAAGCTGCTGCTGAATCTGACAGGGAATTGAACGAAGATGACAGTACAG ATTGTGATGATGATGTTCAAAGAGAAAGAAATGGAGTGATTCAGCACACAGGCGCAGCAGCTGAAGAATTTAATGATGATACTGACTGAT GAAAATAGCATTTATTAATGATTGAGGTATTTGTTTAAAATTCAGTTCATCCAAAATGGAGTAATATCCTTCACCTTCAGTGTGTAACCA AGCACAAAAACAGTATCAATGTTGAATCTGTGAATGGTTTTCCGTTTACTGTGATGTGCTACTGTAAATATACCTCTTTAATTACTTCTG >70052_70052_10_PTK2-RNF139_PTK2_chr8_141710990_ENST00000538769_RNF139_chr8_125498072_ENST00000303545_length(amino acids)=613AA_BP=9 MAGKRGKISGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGY VTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKR IRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDR RLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLW HHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMC LHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PTK2-RNF139 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000340930 | - | 27 | 33 | 912_1052 | 854.0 | 1066.0 | ARHGEF28 |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000521059 | - | 27 | 32 | 912_1052 | 854.0 | 1053.0 | ARHGEF28 |
| Hgene | PTK2 | chr8:141696731 | chr8:125498072 | ENST00000522684 | - | 27 | 32 | 912_1052 | 854.0 | 1053.0 | ARHGEF28 |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000340930 | - | 26 | 33 | 912_1052 | 833.0 | 1066.0 | ARHGEF28 |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000521059 | - | 26 | 32 | 912_1052 | 833.0 | 1053.0 | ARHGEF28 |
| Hgene | PTK2 | chr8:141710990 | chr8:125498072 | ENST00000522684 | - | 26 | 32 | 912_1052 | 833.0 | 1053.0 | ARHGEF28 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PTK2-RNF139 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PTK2-RNF139 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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