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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PTK7-VEGFA (FusionGDB2 ID:70081)

Fusion Gene Summary for PTK7-VEGFA

Fusion gene summary

Fusion gene information	Fusion gene name: PTK7-VEGFA
	Fusion gene ID: 70081
		Hgene	Tgene
	Gene symbol	PTK7	VEGFA
	Gene ID	5754	7422
	Gene name	protein tyrosine kinase 7 (inactive)	vascular endothelial growth factor A
	Synonyms	CCK-4\|CCK4	MVCD1\|VEGF\|VPF
	Cytomap	6p21.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	inactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7	vascular endothelial growth factor Avascular endothelial growth factor A121vascular endothelial growth factor A165vascular permeability factor
	Modification date	20200322	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000230419, ENST00000345201, ENST00000349241, ENST00000352931, ENST00000471863, ENST00000476760, ENST00000481273,	ENST00000230480, ENST00000324450, ENST00000372055, ENST00000372064, ENST00000372067, ENST00000372077, ENST00000413642, ENST00000417285, ENST00000425836, ENST00000457104, ENST00000482630, ENST00000518689, ENST00000518824, ENST00000520948, ENST00000523125, ENST00000523873, ENST00000523950,
Fusion gene scores	* DoF score	15 X 6 X 10=900	10 X 9 X 5=450
	# samples	14	13
	** MAII score	log2(14/900*10)=-2.68449817427207 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTK7 [Title/Abstract] AND VEGFA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PTK7(43044305)-VEGFA(43742078), # samples:2
Anticipated loss of major functional domain due to fusion event.	PTK7-VEGFA seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PTK7-VEGFA seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. PTK7-VEGFA seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	VEGFA	GO:0000122	negative regulation of transcription by RNA polymerase II	18093989
Tgene	VEGFA	GO:0001525	angiogenesis	11427521\|21771332
Tgene	VEGFA	GO:0001666	response to hypoxia	16490744
Tgene	VEGFA	GO:0001934	positive regulation of protein phosphorylation	18386220\|19033661
Tgene	VEGFA	GO:0001938	positive regulation of endothelial cell proliferation	9202027\|10022831\|12714610\|16489009\|18386220\|18577655\|20497126
Tgene	VEGFA	GO:0002042	cell migration involved in sprouting angiogenesis	18059339\|20660291
Tgene	VEGFA	GO:0002092	positive regulation of receptor internalization	20660291
Tgene	VEGFA	GO:0008284	positive regulation of cell proliferation	7929439
Tgene	VEGFA	GO:0008360	regulation of cell shape	7929439\|10527820
Tgene	VEGFA	GO:0010595	positive regulation of endothelial cell migration	10022831\|19033661
Tgene	VEGFA	GO:0010628	positive regulation of gene expression	18386220
Tgene	VEGFA	GO:0010629	negative regulation of gene expression	28977001
Tgene	VEGFA	GO:0010749	regulation of nitric oxide mediated signal transduction	16150726
Tgene	VEGFA	GO:0030224	monocyte differentiation	21149635
Tgene	VEGFA	GO:0030225	macrophage differentiation	21149635
Tgene	VEGFA	GO:0030335	positive regulation of cell migration	7929439\|17470632
Tgene	VEGFA	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	1312256\|7929439
Tgene	VEGFA	GO:0031334	positive regulation of protein complex assembly	16489009\|19033661
Tgene	VEGFA	GO:0031954	positive regulation of protein autophosphorylation	20497126
Tgene	VEGFA	GO:0032147	activation of protein kinase activity	18059339\|20497126
Tgene	VEGFA	GO:0032793	positive regulation of CREB transcription factor activity	20497126
Tgene	VEGFA	GO:0033138	positive regulation of peptidyl-serine phosphorylation	18440775\|20497126
Tgene	VEGFA	GO:0035148	tube formation	19033661
Tgene	VEGFA	GO:0035767	endothelial cell chemotaxis	18440775
Tgene	VEGFA	GO:0035924	cellular response to vascular endothelial growth factor stimulus	18440775\|20497126
Tgene	VEGFA	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	18440775\|20497126\|21245381
Tgene	VEGFA	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	17470632
Tgene	VEGFA	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	19390056
Tgene	VEGFA	GO:0043117	positive regulation of vascular permeability	26598555
Tgene	VEGFA	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	18386220
Tgene	VEGFA	GO:0043406	positive regulation of MAP kinase activity	18440775
Tgene	VEGFA	GO:0043536	positive regulation of blood vessel endothelial cell migration	9202027\|18440775\|20497126
Tgene	VEGFA	GO:0045766	positive regulation of angiogenesis	18440775\|18577655\|19033661\|20497126
Tgene	VEGFA	GO:0045785	positive regulation of cell adhesion	19674970
Tgene	VEGFA	GO:0045944	positive regulation of transcription by RNA polymerase II	18059339
Tgene	VEGFA	GO:0048010	vascular endothelial growth factor receptor signaling pathway	21245381
Tgene	VEGFA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10022831\|16489009\|20048167\|21245381\|26598555
Tgene	VEGFA	GO:0050918	positive chemotaxis	20497126
Tgene	VEGFA	GO:0050927	positive regulation of positive chemotaxis	7929439\|12744932
Tgene	VEGFA	GO:0051272	positive regulation of cellular component movement	10527820\|12744932
Tgene	VEGFA	GO:0051894	positive regulation of focal adhesion assembly	16489009
Tgene	VEGFA	GO:0071456	cellular response to hypoxia	10575000
Tgene	VEGFA	GO:0090037	positive regulation of protein kinase C signaling	18059339
Tgene	VEGFA	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	20551324
Tgene	VEGFA	GO:0097533	cellular stress response to acid chemical	26299712
Tgene	VEGFA	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	20660291
Tgene	VEGFA	GO:1900745	positive regulation of p38MAPK cascade	18386220
Tgene	VEGFA	GO:1901727	positive regulation of histone deacetylase activity	20497126
Tgene	VEGFA	GO:1903141	negative regulation of establishment of endothelial barrier	20048167
Tgene	VEGFA	GO:1903392	negative regulation of adherens junction organization	26598555
Tgene	VEGFA	GO:1903572	positive regulation of protein kinase D signaling	20497126
Tgene	VEGFA	GO:1903672	positive regulation of sprouting angiogenesis	26299712
Tgene	VEGFA	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	26598555

Fusion gene breakpoints across PTK7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VEGFA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A8ID-01A	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
ChimerDB4	PRAD	TCGA-KK-A8ID	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+

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Fusion Gene ORF analysis for PTK7-VEGFA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000230419	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
5CDS-5UTR	ENST00000345201	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
5CDS-5UTR	ENST00000349241	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
5CDS-5UTR	ENST00000352931	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
5CDS-5UTR	ENST00000471863	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
5CDS-5UTR	ENST00000476760	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000230419	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000345201	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000349241	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000352931	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000471863	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
Frame-shift	ENST00000476760	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000324450	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000372055	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000372064	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000372067	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000372077	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000413642	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000417285	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000425836	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000457104	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000482630	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000518689	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000518824	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000520948	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000523125	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000523873	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000481273	ENST00000523950	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+
intron-5UTR	ENST00000481273	ENST00000230480	PTK7	chr6	43044305	+	VEGFA	chr6	43742078	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PTK7-VEGFA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PTK7	chr6	43044305	+	VEGFA	chr6	43742077	+	9.05E-06	0.99999094
PTK7	chr6	43044305	+	VEGFA	chr6	43742077	+	9.05E-06	0.99999094
PTK7	chr6	43044305	+	VEGFA	chr6	43742077	+	9.05E-06	0.99999094
PTK7	chr6	43044305	+	VEGFA	chr6	43742077	+	9.05E-06	0.99999094

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTK7-VEGFA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43044305/:43742078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PTK7-VEGFA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PTK7-VEGFA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PTK7-VEGFA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PTK7-VEGFA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source