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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTOV1-TRIP10 (FusionGDB2 ID:70140)

Fusion Gene Summary for PTOV1-TRIP10

check button Fusion gene summary
Fusion gene informationFusion gene name: PTOV1-TRIP10
Fusion gene ID: 70140
HgeneTgene
Gene symbol

PTOV1

TRIP10

Gene ID

53635

9322

Gene namePTOV1 extended AT-hook containing adaptor proteinthyroid hormone receptor interactor 10
SynonymsACID2|PTOV-1CIP4|HSTP|STOT|STP|TRIP-10
Cytomap

19q13.33

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionprostate tumor-overexpressed gene 1 proteinactivator interaction domain-containing protein 2prostate tumor overexpressed 1cdc42-interacting protein 4TR-interacting protein 10protein Felicsalt tolerant proteinsalt toleratorthyroid receptor-interacting protein 10
Modification date2020032020200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000598325, ENST00000221557, 
ENST00000391842, ENST00000599732, 
ENST00000600603, ENST00000601638, 
ENST00000601675, 		ENST00000600428, 
ENST00000313244, ENST00000313285, 
ENST00000596543, ENST00000596758, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 2=8
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PTOV1 [Title/Abstract] AND TRIP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTOV1(50361371)-TRIP10(6746462), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PTOV1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer131NdPTOV1chr19

50361371

+TRIP10chr19

6746462

+


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Fusion Gene ORF analysis for PTOV1-TRIP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000598325ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+
3UTR-intronENST00000598325ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
3UTR-intronENST00000598325ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
3UTR-intronENST00000598325ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
3UTR-intronENST00000598325ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000221557ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000221557ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000221557ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000221557ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000391842ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000391842ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000391842ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000391842ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000599732ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000599732ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000599732ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000599732ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000600603ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000600603ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000600603ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000600603ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601638ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601638ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601638ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601638ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601675ENST00000313244PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601675ENST00000313285PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601675ENST00000596543PTOV1chr19

50361371

+TRIP10chr19

6746462

+
5CDS-intronENST00000601675ENST00000596758PTOV1chr19

50361371

+TRIP10chr19

6746462

+
In-frameENST00000221557ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+
In-frameENST00000391842ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+
In-frameENST00000599732ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+
In-frameENST00000600603ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+
In-frameENST00000601638ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+
In-frameENST00000601675ENST00000600428PTOV1chr19

50361371

+TRIP10chr19

6746462

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000600603PTOV1chr1950361371+ENST00000600428TRIP10chr196746462+1910967881620510
ENST00000601638PTOV1chr1950361371+ENST00000600428TRIP10chr196746462+1836893141546510
ENST00000221557PTOV1chr1950361371+ENST00000600428TRIP10chr196746462+178384001493497
ENST00000391842PTOV1chr1950361371+ENST00000600428TRIP10chr196746462+20491106471759570
ENST00000599732PTOV1chr1950361371+ENST00000600428TRIP10chr196746462+20171074151727570
ENST00000601675PTOV1chr1950361371+ENST00000600428TRIP10chr196746462+198310401041693529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000600603ENST00000600428PTOV1chr1950361371+TRIP10chr196746462+0.0269967730.9730032
ENST00000601638ENST00000600428PTOV1chr1950361371+TRIP10chr196746462+0.034234270.9657657
ENST00000221557ENST00000600428PTOV1chr1950361371+TRIP10chr196746462+0.0363287480.96367127
ENST00000391842ENST00000600428PTOV1chr1950361371+TRIP10chr196746462+0.0732704250.9267296
ENST00000599732ENST00000600428PTOV1chr1950361371+TRIP10chr196746462+0.075342050.92465794
ENST00000601675ENST00000600428PTOV1chr1950361371+TRIP10chr196746462+0.076255150.9237448

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Fusion Genomic Features for PTOV1-TRIP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTOV1chr1950361371+TRIP10chr196746462+0.100774090.89922595
PTOV1chr1950361371+TRIP10chr196746462+0.100774090.89922595

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTOV1-TRIP10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50361371/chr19:6746462)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915388_481384602.0Coiled coil.
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814388_481328546.0Coiled coil.
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915393_470384602.0DomainREM-1
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915540_601384602.0DomainSH3
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814393_470328546.0DomainREM-1
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814540_601328546.0DomainSH3
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915538_601384602.0RegionNote=Required for podosome formation
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814538_601328546.0RegionNote=Required for podosome formation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIP10chr19:50361371chr19:6746462ENST0000031324491567_259384602.0Coiled coil.
TgeneTRIP10chr19:50361371chr19:6746462ENST0000031328581467_259328546.0Coiled coil.
TgeneTRIP10chr19:50361371chr19:6746462ENST000003132449151_264384602.0DomainF-BAR
TgeneTRIP10chr19:50361371chr19:6746462ENST000003132858141_264328546.0DomainF-BAR
TgeneTRIP10chr19:50361371chr19:6746462ENST000003132449151_117384602.0RegionRequired for translocation to the plasma membrane in response to insulin
TgeneTRIP10chr19:50361371chr19:6746462ENST000003132858141_117328546.0RegionRequired for translocation to the plasma membrane in response to insulin


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Fusion Gene Sequence for PTOV1-TRIP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70140_70140_1_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000221557_TRIP10_chr19_6746462_ENST00000600428_length(transcript)=1783nt_BP=840nt
ATGAGGTCTCCCGCCGTCCCGACCCCCGCAAGGGGCCAGCTTGGTGTCGCCTTCGTTCTTCTGCCACCCCATTCGGAAGGTGCTCGGGTC
TTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCACCCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTG
CTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACCCTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAA
GCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCCGCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACC
CTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTTCACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATG
GGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCCCTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAG
ATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAGTGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCT
GGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTTTCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAG
CCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGTGAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTG
TACATGCAGCTCATCCCGCAGCAGCTGCTGACAGTGGTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAA
CAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACA
CCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTAT
GAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCT
AGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCACAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACC
CCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCACATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGGGTCC
AGCGAGGGCACTATCTCTATGGCCGAGGGTGAAGACCTCAGTCTTATGGAAGAAGACAAAGGGGACGGCTGGACCCGGGTCAGGCGGAAA
GAGGGAGGCGAGGGCTACGTGCCCACCTCCTACCTCCGAGTCACGCTCAATTGAACCCTGCCAGAGACGGGAAGAGGGGGGCTGTCGGCT
GCTGCTTCTGGGCCACGGGGAGCCCCAGGACCTATGCACTTTATTTCTGACCCCGTGGCTTCGGCTGAGACCTGTGTAACCTGCTGCCCC
CTCCACCCCCAACCCAGTCCTACCTGTCACACCGGACGGACCCGCTGTGCCTTCTACCATCGTTCCACCATTGATGTACATACTCATGTT

>70140_70140_1_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000221557_TRIP10_chr19_6746462_ENST00000600428_length(amino acids)=497AA_BP=278
MRSPAVPTPARGQLGVAFVLLPPHSEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQ
AYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKK
IFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKL
YMQLIPQQLLTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKY
EAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGS

--------------------------------------------------------------
>70140_70140_2_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000391842_TRIP10_chr19_6746462_ENST00000600428_length(transcript)=2049nt_BP=1106nt
AGTGGTTCGGCCGCGGCGACCCCACTCCGGCGGCGCGTCCCCCGAGCTTGGTACGGCTCAGCCCGTCTCCCCCGAAGCCGCGCGCCCGCG
CCCGCGCCCCTCAGTCGGTGGAGCCCGCAGCCCCCCTTGTGGCCCGCGGCAGCTCCCCGCCCGCTCGGCCCGCGCCCGCCATGGTCCGTC
CGCGCCGTGCCCCGTACCGCTCCGGCGCCGGGGGCCCCCTCGGGGGTCGCGGCCGCCCTCCGCGGCCCCTCGTGGTGCGCGCCGTCCGCT
CGCGCTCCTGGCCTGCCAGCCCCCGAGGCCCGCAGCCTCCGCGGATCCGGGCCCGCTCGGCCCCTCCCATGGAAGGTGCTCGGGTCTTCG
GGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCACCCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGG
CTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACCCTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCT
ACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCCGCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGG
GCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTTCACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCA
ACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCCCTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCT
TCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAGTGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTG
GTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTTTCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCA
ACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGTGAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACA
TGCAGCTCATCCCGCAGCAGCTGCTGACAGTGGTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGC
AGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTC
AGATGGGGGACCCCGCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGG
CGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCG
CCCCGCCAGACAGCAGCAGCAACAGCGCATCACAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCA
TTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCACATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGGGTCCAGCG
AGGGCACTATCTCTATGGCCGAGGGTGAAGACCTCAGTCTTATGGAAGAAGACAAAGGGGACGGCTGGACCCGGGTCAGGCGGAAAGAGG
GAGGCGAGGGCTACGTGCCCACCTCCTACCTCCGAGTCACGCTCAATTGAACCCTGCCAGAGACGGGAAGAGGGGGGCTGTCGGCTGCTG
CTTCTGGGCCACGGGGAGCCCCAGGACCTATGCACTTTATTTCTGACCCCGTGGCTTCGGCTGAGACCTGTGTAACCTGCTGCCCCCTCC
ACCCCCAACCCAGTCCTACCTGTCACACCGGACGGACCCGCTGTGCCTTCTACCATCGTTCCACCATTGATGTACATACTCATGTTTTAC

>70140_70140_2_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000391842_TRIP10_chr19_6746462_ENST00000600428_length(amino acids)=570AA_BP=351
MVRLSPSPPKPRARARAPQSVEPAAPLVARGSSPPARPAPAMVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRI
RARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQK
LIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAI
RQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTVVTEDF
SHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGD
SLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLME

--------------------------------------------------------------
>70140_70140_3_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000599732_TRIP10_chr19_6746462_ENST00000600428_length(transcript)=2017nt_BP=1074nt
GCGCGTCCCCCGAGCTTGGTACGGCTCAGCCCGTCTCCCCCGAAGCCGCGCGCCCGCGCCCGCGCCCCTCAGTCGGTGGAGCCCGCAGCC
CCCCTTGTGGCCCGCGGCAGCTCCCCGCCCGCTCGGCCCGCGCCCGCCATGGTCCGTCCGCGCCGTGCCCCGTACCGCTCCGGCGCCGGG
GGCCCCCTCGGGGGTCGCGGCCGCCCTCCGCGGCCCCTCGTGGTGCGCGCCGTCCGCTCGCGCTCCTGGCCTGCCAGCCCCCGAGGCCCG
CAGCCTCCGCGGATCCGGGCCCGCTCGGCCCCTCCCATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCT
GGGCTCACCCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAG
CGCAGACCCTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGAC
CAGTGGCCGCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAG
TTCCACTTCACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCAC
ATCTCCCCCTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGC
TTCGTCAGTGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAAC
AACAAGTTTCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCAC
GTCTACGTGAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACAGTG
GTGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAG
GAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAG
ATCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTT
AGCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCA
CAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAG
GAACCCACATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGGGTCCAGCGAGGGCACTATCTCTATGGCCGAGGGTGAAGAC
CTCAGTCTTATGGAAGAAGACAAAGGGGACGGCTGGACCCGGGTCAGGCGGAAAGAGGGAGGCGAGGGCTACGTGCCCACCTCCTACCTC
CGAGTCACGCTCAATTGAACCCTGCCAGAGACGGGAAGAGGGGGGCTGTCGGCTGCTGCTTCTGGGCCACGGGGAGCCCCAGGACCTATG
CACTTTATTTCTGACCCCGTGGCTTCGGCTGAGACCTGTGTAACCTGCTGCCCCCTCCACCCCCAACCCAGTCCTACCTGTCACACCGGA
CGGACCCGCTGTGCCTTCTACCATCGTTCCACCATTGATGTACATACTCATGTTTTACATCTTTTCTTTCTGCCGCTCGGCTCCGGCCAT

>70140_70140_3_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000599732_TRIP10_chr19_6746462_ENST00000600428_length(amino acids)=570AA_BP=351
MVRLSPSPPKPRARARAPQSVEPAAPLVARGSSPPARPAPAMVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRI
RARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQK
LIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAI
RQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTVVTEDF
SHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGD
SLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLME

--------------------------------------------------------------
>70140_70140_4_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000600603_TRIP10_chr19_6746462_ENST00000600428_length(transcript)=1910nt_BP=967nt
GCAATCCGTACCCTCAGTGGGTTCCCTTTCAGTGGGTTCCTTTGTCCCCAGGCCCATTATTCCGTCCTCCCCTCTTCCCTGATGTATTTT
GGCGCGGTCTCCTGGCTCTGCGGGCCCAGGGCTCCGGATGAGGTCTCCCGCCGTCCCGACCCCCGCAAGGGGCCAGCTTGGTGTCGCCTT
CGTTCTTCTGCCACCCCATTCGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCACCCTCGGGGG
TCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACCCTACTCTGA
CTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCCGCAGAAGCT
GATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTTCACCAACAG
AGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCCCTGTGAGGT
GCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAGTGCCATCCG
GCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTTTCTGGCATG
GAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGTGAACCAGGG
GGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACAGTGGTGACCGAGGATTTTAG
CCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAGAGGGA
AGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAG
CAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGAGACAG
CCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCACAGGACACCAAGGAGAG
CTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCACATCCCCCAT
AGGTCACTGTGTGGCCATCTACCACTTTGAAGGGTCCAGCGAGGGCACTATCTCTATGGCCGAGGGTGAAGACCTCAGTCTTATGGAAGA
AGACAAAGGGGACGGCTGGACCCGGGTCAGGCGGAAAGAGGGAGGCGAGGGCTACGTGCCCACCTCCTACCTCCGAGTCACGCTCAATTG
AACCCTGCCAGAGACGGGAAGAGGGGGGCTGTCGGCTGCTGCTTCTGGGCCACGGGGAGCCCCAGGACCTATGCACTTTATTTCTGACCC
CGTGGCTTCGGCTGAGACCTGTGTAACCTGCTGCCCCCTCCACCCCCAACCCAGTCCTACCTGTCACACCGGACGGACCCGCTGTGCCTT
CTACCATCGTTCCACCATTGATGTACATACTCATGTTTTACATCTTTTCTTTCTGCCGCTCGGCTCCGGCCATTTTGTTTTATACAAAAA

>70140_70140_4_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000600603_TRIP10_chr19_6746462_ENST00000600428_length(amino acids)=510AA_BP=291
MARSPGSAGPGLRMRSPAVPTPARGQLGVAFVLLPPHSEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYS
DSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCE
VRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQ
GEILRTEQWPRKLYMQLIPQQLLTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETL
SNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSP

--------------------------------------------------------------
>70140_70140_5_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000601638_TRIP10_chr19_6746462_ENST00000600428_length(transcript)=1836nt_BP=893nt
TTCCCTGATGTATTTTGGCGCGGTCTCCTGGCTCTGCGGGCCCAGGGCTCCGGATGAGGTCTCCCGCCGTCCCGACCCCCGCAAGGGGCC
AGCTTGGTGTCGCCTTCGTTCTTCTGCCACCCCATTCGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTG
GGCTCACCCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGC
GCAGACCCTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACC
AGTGGCCGCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGT
TCCACTTCACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACA
TCTCCCCCTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCT
TCGTCAGTGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACA
ACAAGTTTCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACG
TCTACGTGAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACAGTGG
TGACCGAGGATTTTAGCCACTTGCCCCCAGAGCAGCAGCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGG
AGGTTGACCAGAGGGAAGCCCTAAAGAAAATGAAGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAGA
TCGCTGAAACCCTGAGCAACATTGAACGGCTGAAATTGGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTA
GCAACCGGGGAGACAGCCTGAGCCGGCACGCCCGGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCAC
AGGACACCAAGGAGAGCTCTGAAGAGCCTCCCTCAGAAGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGG
AACCCACATCCCCCATAGGTCACTGTGTGGCCATCTACCACTTTGAAGGGTCCAGCGAGGGCACTATCTCTATGGCCGAGGGTGAAGACC
TCAGTCTTATGGAAGAAGACAAAGGGGACGGCTGGACCCGGGTCAGGCGGAAAGAGGGAGGCGAGGGCTACGTGCCCACCTCCTACCTCC
GAGTCACGCTCAATTGAACCCTGCCAGAGACGGGAAGAGGGGGGCTGTCGGCTGCTGCTTCTGGGCCACGGGGAGCCCCAGGACCTATGC
ACTTTATTTCTGACCCCGTGGCTTCGGCTGAGACCTGTGTAACCTGCTGCCCCCTCCACCCCCAACCCAGTCCTACCTGTCACACCGGAC
GGACCCGCTGTGCCTTCTACCATCGTTCCACCATTGATGTACATACTCATGTTTTACATCTTTTCTTTCTGCCGCTCGGCTCCGGCCATT

>70140_70140_5_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000601638_TRIP10_chr19_6746462_ENST00000600428_length(amino acids)=510AA_BP=291
MARSPGSAGPGLRMRSPAVPTPARGQLGVAFVLLPPHSEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYS
DSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCE
VRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQ
GEILRTEQWPRKLYMQLIPQQLLTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETL
SNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSP

--------------------------------------------------------------
>70140_70140_6_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000601675_TRIP10_chr19_6746462_ENST00000600428_length(transcript)=1983nt_BP=1040nt
CTCCCCCGAAGCCGCGCGCCCGCGCCCGCGCCCCTCAGTCGGTGGAGCCCGCAGCCCCCCTTGTGGCCCGCGGCAGCTCCCCGCCCGCTC
GGCCCGCGCCCGCCATGGTCCGTCCGCGCCGTGCCCCGTACCGCTCCGGCGCCGGGGGCCCCCTCGGGGGTCGCGGCCGCCCTCCGCGGC
CCCTCGTGGTGCGCGCCGTCCGCTCGCGCTCCTGGCCTGCCAGCCCCCGAGGCCCGCAGCCTCCGCGGATCCGGGCCCGCTCGGCCCCTC
CCATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCACCCTCGGGGGTCTGGCCGTGAGCGAGC
ACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACCCTACTCTGACTCCACTGCAAAGCTGA
AGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCCGCAGAAGCTGATCATGCAGCTGATCC
CTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTTCACCAACAGAGACTGCGACTCGCTCA
AGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCCCTGTGAGGTGCGCGTGCTCATGCTCC
TGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAGTGCCATCCGGCAGGTCATCACCACCC
GCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTTTCTGGCATGGAGTGGTGTCATGGAGT
GGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGTGAACCAGGGGGAGATCCTGAGGACCG
AGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACAGTGGTGACCGAGGATTTTAGCCACTTGCCCCCAGAGC
AGCAGCGAAAACGGCTTCAACAGCAGTTGGAAGAACGCAGTCGTGAACTTCAGAAGGAGGTTGACCAGAGGGAAGCCCTAAAGAAAATGA
AGGATGTCTATGAGAAGACACCTCAGATGGGGGACCCCGCCAGCTTGGAGCCCCAGATCGCTGAAACCCTGAGCAACATTGAACGGCTGA
AATTGGAAGTGCAGAAGTATGAGGCGTGGCTGGCAGAAGCTGAAAGTCGAGTCCTTAGCAACCGGGGAGACAGCCTGAGCCGGCACGCCC
GGCCTCCCGACCCCCCCGCTAGCGCCCCGCCAGACAGCAGCAGCAACAGCGCATCACAGGACACCAAGGAGAGCTCTGAAGAGCCTCCCT
CAGAAGAGAGCCAGGACACCCCCATTTACACGGAGTTTGATGAGGATTTCGAGGAGGAACCCACATCCCCCATAGGTCACTGTGTGGCCA
TCTACCACTTTGAAGGGTCCAGCGAGGGCACTATCTCTATGGCCGAGGGTGAAGACCTCAGTCTTATGGAAGAAGACAAAGGGGACGGCT
GGACCCGGGTCAGGCGGAAAGAGGGAGGCGAGGGCTACGTGCCCACCTCCTACCTCCGAGTCACGCTCAATTGAACCCTGCCAGAGACGG
GAAGAGGGGGGCTGTCGGCTGCTGCTTCTGGGCCACGGGGAGCCCCAGGACCTATGCACTTTATTTCTGACCCCGTGGCTTCGGCTGAGA
CCTGTGTAACCTGCTGCCCCCTCCACCCCCAACCCAGTCCTACCTGTCACACCGGACGGACCCGCTGTGCCTTCTACCATCGTTCCACCA
TTGATGTACATACTCATGTTTTACATCTTTTCTTTCTGCCGCTCGGCTCCGGCCATTTTGTTTTATACAAAAATGGGAAAAAAAAAAAAG

>70140_70140_6_PTOV1-TRIP10_PTOV1_chr19_50361371_ENST00000601675_TRIP10_chr19_6746462_ENST00000600428_length(amino acids)=529AA_BP=310
MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSN
KLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCR
IMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPR
PEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYE
KTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTOV1-TRIP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915546_601384.0602.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814546_601328.0546.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915529_601384.0602.0DNM1 and WASL
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814529_601328.0546.0DNM1 and WASL
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915487_541384.0602.0DNM2 and WASL
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814487_541328.0546.0DNM2 and WASL
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915544_601384.0602.0WAS
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814544_601328.0546.0WAS


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTOV1chr19:50361371chr19:6746462ENST00000221557+912184_416280.0375.0FLOT1
HgenePTOV1chr19:50361371chr19:6746462ENST00000391842+912184_416312.0417.0FLOT1
HgenePTOV1chr19:50361371chr19:6746462ENST00000599732+913184_416312.0357.6666666666667FLOT1
HgenePTOV1chr19:50361371chr19:6746462ENST00000600603+913184_416280.0365.6666666666667FLOT1
HgenePTOV1chr19:50361371chr19:6746462ENST00000601675+913184_416312.0383.6666666666667FLOT1
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915293_537384.0602.0CDC42
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814293_537328.0546.0CDC42
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313244915293_601384.0602.0PDE6G
TgeneTRIP10chr19:50361371chr19:6746462ENST00000313285814293_601328.0546.0PDE6G


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTOV1-TRIP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTOV1-TRIP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource