|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PTPN12-UBR1 (FusionGDB2 ID:70205) |
Fusion Gene Summary for PTPN12-UBR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN12-UBR1 | Fusion gene ID: 70205 | Hgene | Tgene | Gene symbol | PTPN12 | UBR1 | Gene ID | 5782 | 197131 |
| Gene name | protein tyrosine phosphatase non-receptor type 12 | ubiquitin protein ligase E3 component n-recognin 1 | |
| Synonyms | PTP-PEST|PTPG1 | JBS | |
| Cytomap | 7q11.23 | 15q15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1 | E3 ubiquitin-protein ligase UBR1E3a ligaseN-recognin-1RING-type E3 ubiquitin transferase UBR1ubiquitin ligase E3 alpha-Iubiquitin-protein ligase E3-alphaubiquitin-protein ligase E3-alpha-1ubiquitin-protein ligase E3-alpha-I | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000248594, ENST00000415482, ENST00000435495, | ENST00000382177, ENST00000568782, ENST00000290650, | |
| Fusion gene scores | * DoF score | 22 X 21 X 16=7392 | 6 X 6 X 3=108 |
| # samples | 44 | 6 | |
| ** MAII score | log2(44/7392*10)=-4.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN12 [Title/Abstract] AND UBR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PTPN12(77230123)-UBR1(43294902), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN12 | GO:0006470 | protein dephosphorylation | 27134172 |
| Hgene | PTPN12 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27134172 |
| Tgene | UBR1 | GO:0071233 | cellular response to leucine | 20298436 |
| Fusion gene breakpoints across PTPN12 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across UBR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-BG-A2AD-11A | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
Top |
Fusion Gene ORF analysis for PTPN12-UBR1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000248594 | ENST00000382177 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| 5CDS-3UTR | ENST00000415482 | ENST00000382177 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| 5CDS-3UTR | ENST00000435495 | ENST00000382177 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| 5CDS-intron | ENST00000248594 | ENST00000568782 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| 5CDS-intron | ENST00000415482 | ENST00000568782 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| 5CDS-intron | ENST00000435495 | ENST00000568782 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| In-frame | ENST00000248594 | ENST00000290650 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| In-frame | ENST00000415482 | ENST00000290650 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| In-frame | ENST00000435495 | ENST00000290650 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000248594 | PTPN12 | chr7 | 77230123 | + | ENST00000290650 | UBR1 | chr15 | 43294902 | - | 5140 | 967 | 2 | 2707 | 901 |
| ENST00000415482 | PTPN12 | chr7 | 77230123 | + | ENST00000290650 | UBR1 | chr15 | 43294902 | - | 4841 | 668 | 84 | 2408 | 774 |
| ENST00000435495 | PTPN12 | chr7 | 77230123 | + | ENST00000290650 | UBR1 | chr15 | 43294902 | - | 4711 | 538 | 50 | 2278 | 742 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000248594 | ENST00000290650 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - | 0.000307924 | 0.9996921 |
| ENST00000415482 | ENST00000290650 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - | 0.000262828 | 0.9997372 |
| ENST00000435495 | ENST00000290650 | PTPN12 | chr7 | 77230123 | + | UBR1 | chr15 | 43294902 | - | 0.001092247 | 0.9989078 |
Top |
Fusion Genomic Features for PTPN12-UBR1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for PTPN12-UBR1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:77230123/chr15:43294902) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000248594 | + | 8 | 18 | 63_67 | 231 | 781.0 | Region | Substrate binding |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000435495 | + | 7 | 17 | 63_67 | 101 | 651.0 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000248594 | + | 8 | 18 | 28_293 | 231 | 781.0 | Domain | Tyrosine-protein phosphatase |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000435495 | + | 7 | 17 | 28_293 | 101 | 651.0 | Domain | Tyrosine-protein phosphatase |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000248594 | + | 8 | 18 | 231_237 | 231 | 781.0 | Region | Substrate binding |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000435495 | + | 7 | 17 | 231_237 | 101 | 651.0 | Region | Substrate binding |
| Tgene | UBR1 | chr7:77230123 | chr15:43294902 | ENST00000290650 | 30 | 47 | 864_869 | 1169 | 1750.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | UBR1 | chr7:77230123 | chr15:43294902 | ENST00000382177 | 29 | 46 | 864_869 | 1152 | 1599.6666666666667 | Compositional bias | Note=Poly-Pro | |
| Tgene | UBR1 | chr7:77230123 | chr15:43294902 | ENST00000290650 | 30 | 47 | 1098_1201 | 1169 | 1750.0 | Zinc finger | Note=RING-type%3B atypical | |
| Tgene | UBR1 | chr7:77230123 | chr15:43294902 | ENST00000290650 | 30 | 47 | 97_168 | 1169 | 1750.0 | Zinc finger | UBR-type | |
| Tgene | UBR1 | chr7:77230123 | chr15:43294902 | ENST00000382177 | 29 | 46 | 1098_1201 | 1152 | 1599.6666666666667 | Zinc finger | Note=RING-type%3B atypical | |
| Tgene | UBR1 | chr7:77230123 | chr15:43294902 | ENST00000382177 | 29 | 46 | 97_168 | 1152 | 1599.6666666666667 | Zinc finger | UBR-type |
Top |
Fusion Gene Sequence for PTPN12-UBR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >70205_70205_1_PTPN12-UBR1_PTPN12_chr7_77230123_ENST00000248594_UBR1_chr15_43294902_ENST00000290650_length(transcript)=5140nt_BP=967nt AGCTGGGGGTTGGGGTTGGCGCTAGCGCAGCGGCTCGCCTGGTACTGTGGGAGAGCGGCGGCTGCTCCTGGAAGTTGTGGTGTCGGGAGC CCAGCCGGTGCCGCCGCAGCCGCCGCCTAGGGCGGTGGGGAGGAGGAGGGAGCCGCGGGGCTTGGCGGGGTCGGGAGGGAGGGACGTGCT GGGGGAACGAGCTGGGGAAGACGGAGCGGGCTCTGTGCCGGGCGGGCGGGCGGCGGGGGGGCCAGCGACCGCAGCCGGGGGGACGCGGGA GGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCC GGGACTTCATGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTA AAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGATTCAGACTATATCA ATGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATAGATTTTTGGAGGA TGATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGCTATTGGCCTTTGT ATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATCAGGACACTCTTAC TTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCATTTGATTCTATTC TGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGGTATTTTGAAGCTGTACAGCTGA GCTCTCAGCAGCGCATTCATGTTGACCTTTTTGACTTGGAAAGTGGAGAATATCTTTGCCCTCTTTGCAAATCTCTGTGCAATACTGTGA TCCCCATTATTCCTTTGCAACCTCAAAAGATAAACAGTGAGAATGCAGATGCTCTTGCTCAACTTTTGACCCTGGCACGGTGGATACAGA CTGTTCTGGCCAGAATATCAGGTTATAATATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTCTTTAATCAAGGAATGGGAGATT CTACTTTGGAGTTCCATTCCATCCTGAGTTTTGGCGTTGAGTCTTCGATTAAATATTCAAATAGCATCAAGGAAATGGTTATTCTCTTTG CCACAACAATTTATAGAATTGGATTGAAAGTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTGACCTGGAGCACCTGCGCTTTCA CTATCCAGGCAATTGAAAATCTATTGGGAGATGAAGGAAAACCTCTGTTTGGAGCACTTCAAAATAGGCAGCATAATGGTCTGAAAGCAT TAATGCAGTTTGCAGTTGCACAGAGGATTACCTGTCCTCAGGTCCTGATACAGAAACATCTGGTTCGTCTTCTATCAGTTGTTCTTCCTA ACATAAAATCAGAAGATACACCATGCCTTCTGTCTATAGATCTGTTTCATGTTTTGGTGGGTGCTGTGTTAGCATTCCCATCCTTGTATT GGGATGACCCTGTTGATCTGCAGCCTTCTTCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCATTTGATCACCATGGCACACATGC TTCAGATACTACTTACAGTAGACACAGGCCTACCCCTTGCTCAGGTTCAAGAAGACAGTGAAGAGGCTCATTCCGCATCTTCTTTCTTTG CAGAAATTTCTCAATATACAAGTGGCTCCATTGGGTGTGATATTCCTGGCTGGTATTTGTGGGTCTCACTGAAGAATGGCATCACCCCTT ATCTTCGCTGTGCTGCATTGTTTTTCCACTATTTACTTGGGGTAACTCCGCCTGAGGAACTGCATACCAATTCTGCAGAAGGAGAGTACA GTGCACTCTGTAGCTATCTATCTTTACCTACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACTGTAAGGCCCTTGCTCCAGAGGT GGTGTGCAGATCCTGCCTTACTAAACTGTTTGAAGCAAAAAAACACCGTGGTCAGGTACCCTAGAAAAAGAAATAGTTTGATAGAGCTTC CTGATGACTATAGCTGCCTCCTGAATCAAGCTTCTCATTTCAGGTGCCCACGGTCTGCAGATGATGAGCGAAAGCATCCTGTCCTCTGCC TTTTCTGTGGGGCTATACTATGTTCTCAGAACATTTGCTGCCAGGAAATTGTGAACGGGGAAGAGGTTGGAGCTTGCATTTTTCACGCAC TTCACTGTGGAGCCGGAGTCTGCATTTTCCTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGTAAAGCCAGAGGCTGTGCCTATC CAGCTCCTTACTTGGATGAATATGGAGAAACAGACCCTGGCCTGAAGAGGGGCAACCCCCTTCATTTATCTCGTGAGCGGTATCGGAAGC TCCATTTGGTCTGGCAACAACACTGCATTATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATGTTATTTGGATTCAACTGGCAGT TACTGTGAGCTCCAACTCTGCCTCAAGACAATCACAAATGACGACAGTAGTAAAGGCTGATTCAAAATTATGGAAAACTTTCTGAGGGCT GGGAAAGTATTGGAGGGTCTTTTGCTCCATGTCCAGGTTCACTTACATCAATAAAATATTTCTTAATGGAGTATTGCTTTCAATTAGCAA ACATATGCTTCACAGGAAAAAAGGACATAGATCAATCTGTTTTATGTGCTAGTATTTCCAGGAATTTATTCCCCTTCATAATTTGTCTCA TTTCATTTTATTTCATCCACTTGGTAGATGAAGTCACGTCAAACAGTTGTAGACATTTTATATGTTGGTTAACTCTTCTGCAATTTTGTA TTTGGTGTTTTCCCCCCAAGTTTAGTTCAACTGACATTGGATCACTGACAAAATTCTAATAATCTGTGATAGTCTTCCTTGCAGTTAAAG AAGAATTGCAGAAACCATGCAATATACTTGGGAAAGATTCCAAAAATAAATTTTTTATTATTTCTCTTTTAAGGAAATACCCCTAATGTG CCACCTGCTGCTATCACCACAAATTAAACTCAATCTCTATGTGGACAGAGGATGATTTCTGCCAATATGGAAAAGCTTTTTTCTCACTGT AGGCCTCAAGAAAAGTTAGGGTAATGTATTTGTTATTCATTCCTGACGGTACAAAGAGCTTGCAGTTCTCACCTCTGACTACCAGTAGCT TTGTTGAGTTTTGAAATAATACTTGACATTTTCCAAAGGCAAATCTCATTCTGCAAGGAGATTGTGGCACCATCCTGTTTGACTCTCAGA AACCTCTTGTAATTCTGATGTAAAAACTGTAGAATGAAGATGAGAAAATTCTCGCAATGAGTGGATCATGACAACTGTAAATTAGAACAA TCAGATTTAAACCAATTCCGCAGTCTTCTATATCTTTGTAAAAGACAAATCCTTGATGTTGTCTGTGTGCAACCTTTTCATAAACTCTGG TTTTATGACTAGTACAAACCACCAAAAAAGCCATGTGATCAATAGTCTGTGTCCTGTTATAACATGCTGTGGTTGAGCCATCTTGTTTAT AAATAATAGAGCTCTCCTGAATTTGTGCATAGACTTCTTGGTTCCTGGCTTTTGTTTTTTGTATCAAGAGATTGTGATATAAAACAGCAG AAGATAAATGGAAACCTTCCATTTTAACTTACGTTGTTTCTGGGGTAATGTTAGAACCTTGAAAGATGCATTCAAAGACTGTATCTTATT TTGCCCTTGGCTATTAGTGTCTCACATATGTGTGTAAATGTTTTCCTACCTTCTTTTTGCTCAGCAAAGGCAAGCAAGTAAAATATATTT GCTAAGTGATTAGTGATGCACATTTGGGGCTAGATTTTTTTGGTACTTTTATGTAAAGAAAAGTGGATTTTGCAGTAAGGGATTGGCATG AGCAGGCGTCAGAATCACAATCATGATTTTCTACTTGAATAATTACAATTCAGAAGGTATCTGGATAAATAGATACATGTCTAGTGAACA ATTTGTAACAATAACAGGTAAGGATCAGGAAATTCAGTATTCAGTTTGTCAGATTTGCCAGAATGATGAAAGTATTTGAACATGTGTGTT TGTTTCTTATATAATTGTATTGAGTGGATTGTTTGACTGGGAAATCTGGGCTAGAATAGGAAACAGAAGATACTGACTTCTACCCTAATA GATGGGCCCCAATTTAGCAAAGATAAACTGACTTTATTTTTAGTCCTTTTTATATTAACTTAATAAATTCTGGAGTTAGGCTCTCAAGAG GACAGAGGGACTGTCTGGCAATGGCCAGCCAGACCTTTACTGCCAAAGAACCCATTTCATATTGCGTTCCACTGATTGAGATTGATTCAG ATTTTTGCACTGTAGATGAGCGTATGTCTCAGTGCTGCCCCAAGCCCCAGGGATTTCTCATTATGTTCAAATGTCCTAGTGATTTACCTT AATCATTGCAAACAATTATGCTTATGAAGTTTACTTACAAACAAGCAACTGAGTCACTTTATTTTCTTTAGTGTAGTATGTGAAGGCACT GGTTCAACAGGATGGCTCCAGAACTGTGTTTTTCTAATGTTTGGTAAGGGGCTAGTGAGAATTTTAATGATATGGTGAAGAAAAATATAT CTGTATAATTAATTTATTATATTGGTGTATGGGCTGTGAGTTCACCTTTTAGTGGTCATTTGTCATTTCATAACAACTATGCATTTTGGT TCACTGTGATGATGATCTATATTTAGTGACTGCAACATGTTTATACCACTGATTCAAATTCCATCCATGATGAAGTTATACAAATAATGC ATATATTGATAACTTTTATTGCAAAAATGTAAATTTAAAACTTGTATAATGTTCTTGTGCTTTTTAAAATAAAATATATGTGTATATTTA >70205_70205_1_PTPN12-UBR1_PTPN12_chr7_77230123_ENST00000248594_UBR1_chr15_43294902_ENST00000290650_length(amino acids)=901AA_BP=320 LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCRYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVI PIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIFFNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFA TTIYRIGLKVPPDERDPRVPMLTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVRLLSVVLPN IKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFHLITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFA EISQYTSGSIGCDIPGWYLWVSLKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDTVRPLLQRW CADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHAL HCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQL -------------------------------------------------------------- >70205_70205_2_PTPN12-UBR1_PTPN12_chr7_77230123_ENST00000415482_UBR1_chr15_43294902_ENST00000290650_length(transcript)=4841nt_BP=668nt GTCGAGGCAAGGTATCTGGCTGTGACCGGGAGGAGTGCAGATCGTGGCTGACAGAGGAACGGGGGTATTGAGCGGTTAAGAAGATTGTCT ACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTAAAAAGAACAGATACAAGGACATACTGCCA TTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGATTCAGACTATATCAATGCAAATTTTATAAAGGGCGTCTATGGG CCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATAGATTTTTGGAGGATGATATGGGAGTATAATGTTGTGATCATT GTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGCTATTGGCCTTTGTATGGAGAAGACCCCATAACGTTTGCACCA TTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATCAGGACACTCTTACTTGAATTTCAAAATGAATCTCGTAGGCTG TATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCATTTGATTCTATTCTGGACATGATAAGCTTAATGAGGAAATAT CAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGGTATTTTGAAGCTGTACAGCTGAGCTCTCAGCAGCGCATTCATGTTGACCTT TTTGACTTGGAAAGTGGAGAATATCTTTGCCCTCTTTGCAAATCTCTGTGCAATACTGTGATCCCCATTATTCCTTTGCAACCTCAAAAG ATAAACAGTGAGAATGCAGATGCTCTTGCTCAACTTTTGACCCTGGCACGGTGGATACAGACTGTTCTGGCCAGAATATCAGGTTATAAT ATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTCTTTAATCAAGGAATGGGAGATTCTACTTTGGAGTTCCATTCCATCCTGAGT TTTGGCGTTGAGTCTTCGATTAAATATTCAAATAGCATCAAGGAAATGGTTATTCTCTTTGCCACAACAATTTATAGAATTGGATTGAAA GTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTGACCTGGAGCACCTGCGCTTTCACTATCCAGGCAATTGAAAATCTATTGGGA GATGAAGGAAAACCTCTGTTTGGAGCACTTCAAAATAGGCAGCATAATGGTCTGAAAGCATTAATGCAGTTTGCAGTTGCACAGAGGATT ACCTGTCCTCAGGTCCTGATACAGAAACATCTGGTTCGTCTTCTATCAGTTGTTCTTCCTAACATAAAATCAGAAGATACACCATGCCTT CTGTCTATAGATCTGTTTCATGTTTTGGTGGGTGCTGTGTTAGCATTCCCATCCTTGTATTGGGATGACCCTGTTGATCTGCAGCCTTCT TCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCATTTGATCACCATGGCACACATGCTTCAGATACTACTTACAGTAGACACAGGC CTACCCCTTGCTCAGGTTCAAGAAGACAGTGAAGAGGCTCATTCCGCATCTTCTTTCTTTGCAGAAATTTCTCAATATACAAGTGGCTCC ATTGGGTGTGATATTCCTGGCTGGTATTTGTGGGTCTCACTGAAGAATGGCATCACCCCTTATCTTCGCTGTGCTGCATTGTTTTTCCAC TATTTACTTGGGGTAACTCCGCCTGAGGAACTGCATACCAATTCTGCAGAAGGAGAGTACAGTGCACTCTGTAGCTATCTATCTTTACCT ACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACTGTAAGGCCCTTGCTCCAGAGGTGGTGTGCAGATCCTGCCTTACTAAACTGT TTGAAGCAAAAAAACACCGTGGTCAGGTACCCTAGAAAAAGAAATAGTTTGATAGAGCTTCCTGATGACTATAGCTGCCTCCTGAATCAA GCTTCTCATTTCAGGTGCCCACGGTCTGCAGATGATGAGCGAAAGCATCCTGTCCTCTGCCTTTTCTGTGGGGCTATACTATGTTCTCAG AACATTTGCTGCCAGGAAATTGTGAACGGGGAAGAGGTTGGAGCTTGCATTTTTCACGCACTTCACTGTGGAGCCGGAGTCTGCATTTTC CTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGTAAAGCCAGAGGCTGTGCCTATCCAGCTCCTTACTTGGATGAATATGGAGAA ACAGACCCTGGCCTGAAGAGGGGCAACCCCCTTCATTTATCTCGTGAGCGGTATCGGAAGCTCCATTTGGTCTGGCAACAACACTGCATT ATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATGTTATTTGGATTCAACTGGCAGTTACTGTGAGCTCCAACTCTGCCTCAAGAC AATCACAAATGACGACAGTAGTAAAGGCTGATTCAAAATTATGGAAAACTTTCTGAGGGCTGGGAAAGTATTGGAGGGTCTTTTGCTCCA TGTCCAGGTTCACTTACATCAATAAAATATTTCTTAATGGAGTATTGCTTTCAATTAGCAAACATATGCTTCACAGGAAAAAAGGACATA GATCAATCTGTTTTATGTGCTAGTATTTCCAGGAATTTATTCCCCTTCATAATTTGTCTCATTTCATTTTATTTCATCCACTTGGTAGAT GAAGTCACGTCAAACAGTTGTAGACATTTTATATGTTGGTTAACTCTTCTGCAATTTTGTATTTGGTGTTTTCCCCCCAAGTTTAGTTCA ACTGACATTGGATCACTGACAAAATTCTAATAATCTGTGATAGTCTTCCTTGCAGTTAAAGAAGAATTGCAGAAACCATGCAATATACTT GGGAAAGATTCCAAAAATAAATTTTTTATTATTTCTCTTTTAAGGAAATACCCCTAATGTGCCACCTGCTGCTATCACCACAAATTAAAC TCAATCTCTATGTGGACAGAGGATGATTTCTGCCAATATGGAAAAGCTTTTTTCTCACTGTAGGCCTCAAGAAAAGTTAGGGTAATGTAT TTGTTATTCATTCCTGACGGTACAAAGAGCTTGCAGTTCTCACCTCTGACTACCAGTAGCTTTGTTGAGTTTTGAAATAATACTTGACAT TTTCCAAAGGCAAATCTCATTCTGCAAGGAGATTGTGGCACCATCCTGTTTGACTCTCAGAAACCTCTTGTAATTCTGATGTAAAAACTG TAGAATGAAGATGAGAAAATTCTCGCAATGAGTGGATCATGACAACTGTAAATTAGAACAATCAGATTTAAACCAATTCCGCAGTCTTCT ATATCTTTGTAAAAGACAAATCCTTGATGTTGTCTGTGTGCAACCTTTTCATAAACTCTGGTTTTATGACTAGTACAAACCACCAAAAAA GCCATGTGATCAATAGTCTGTGTCCTGTTATAACATGCTGTGGTTGAGCCATCTTGTTTATAAATAATAGAGCTCTCCTGAATTTGTGCA TAGACTTCTTGGTTCCTGGCTTTTGTTTTTTGTATCAAGAGATTGTGATATAAAACAGCAGAAGATAAATGGAAACCTTCCATTTTAACT TACGTTGTTTCTGGGGTAATGTTAGAACCTTGAAAGATGCATTCAAAGACTGTATCTTATTTTGCCCTTGGCTATTAGTGTCTCACATAT GTGTGTAAATGTTTTCCTACCTTCTTTTTGCTCAGCAAAGGCAAGCAAGTAAAATATATTTGCTAAGTGATTAGTGATGCACATTTGGGG CTAGATTTTTTTGGTACTTTTATGTAAAGAAAAGTGGATTTTGCAGTAAGGGATTGGCATGAGCAGGCGTCAGAATCACAATCATGATTT TCTACTTGAATAATTACAATTCAGAAGGTATCTGGATAAATAGATACATGTCTAGTGAACAATTTGTAACAATAACAGGTAAGGATCAGG AAATTCAGTATTCAGTTTGTCAGATTTGCCAGAATGATGAAAGTATTTGAACATGTGTGTTTGTTTCTTATATAATTGTATTGAGTGGAT TGTTTGACTGGGAAATCTGGGCTAGAATAGGAAACAGAAGATACTGACTTCTACCCTAATAGATGGGCCCCAATTTAGCAAAGATAAACT GACTTTATTTTTAGTCCTTTTTATATTAACTTAATAAATTCTGGAGTTAGGCTCTCAAGAGGACAGAGGGACTGTCTGGCAATGGCCAGC CAGACCTTTACTGCCAAAGAACCCATTTCATATTGCGTTCCACTGATTGAGATTGATTCAGATTTTTGCACTGTAGATGAGCGTATGTCT CAGTGCTGCCCCAAGCCCCAGGGATTTCTCATTATGTTCAAATGTCCTAGTGATTTACCTTAATCATTGCAAACAATTATGCTTATGAAG TTTACTTACAAACAAGCAACTGAGTCACTTTATTTTCTTTAGTGTAGTATGTGAAGGCACTGGTTCAACAGGATGGCTCCAGAACTGTGT TTTTCTAATGTTTGGTAAGGGGCTAGTGAGAATTTTAATGATATGGTGAAGAAAAATATATCTGTATAATTAATTTATTATATTGGTGTA TGGGCTGTGAGTTCACCTTTTAGTGGTCATTTGTCATTTCATAACAACTATGCATTTTGGTTCACTGTGATGATGATCTATATTTAGTGA CTGCAACATGTTTATACCACTGATTCAAATTCCATCCATGATGAAGTTATACAAATAATGCATATATTGATAACTTTTATTGCAAAAATG >70205_70205_2_PTPN12-UBR1_PTPN12_chr7_77230123_ENST00000415482_UBR1_chr15_43294902_ENST00000290650_length(amino acids)=774AA_BP=193 MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR KYQEHEDVPICIHCRYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISG YNIRHAKGENPIPIFFNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPMLTWSTCAFTIQAIENL LGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVRLLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQ PSSVSSSYNHLYLFHLITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVSLKNGITPYLRCAALF FHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDTVRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLL NQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEY -------------------------------------------------------------- >70205_70205_3_PTPN12-UBR1_PTPN12_chr7_77230123_ENST00000435495_UBR1_chr15_43294902_ENST00000290650_length(transcript)=4711nt_BP=538nt GTGCAGATCGTGGCTGACAGAGGAACGGGGGTATTGAGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAG CCACTGGAGAAAAAGAAGAAAATGTTAAAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGA CTCCTTCACAAGATTCAGACTATATCAATGCAAATTTTATAAAGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAAT GTGAGCGCTATTGGCCTTTGTATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACT ACTTCATCAGGACACTCTTACTTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTC CTTCATCATTTGATTCTATTCTGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGGT ATTTTGAAGCTGTACAGCTGAGCTCTCAGCAGCGCATTCATGTTGACCTTTTTGACTTGGAAAGTGGAGAATATCTTTGCCCTCTTTGCA AATCTCTGTGCAATACTGTGATCCCCATTATTCCTTTGCAACCTCAAAAGATAAACAGTGAGAATGCAGATGCTCTTGCTCAACTTTTGA CCCTGGCACGGTGGATACAGACTGTTCTGGCCAGAATATCAGGTTATAATATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTCT TTAATCAAGGAATGGGAGATTCTACTTTGGAGTTCCATTCCATCCTGAGTTTTGGCGTTGAGTCTTCGATTAAATATTCAAATAGCATCA AGGAAATGGTTATTCTCTTTGCCACAACAATTTATAGAATTGGATTGAAAGTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTGA CCTGGAGCACCTGCGCTTTCACTATCCAGGCAATTGAAAATCTATTGGGAGATGAAGGAAAACCTCTGTTTGGAGCACTTCAAAATAGGC AGCATAATGGTCTGAAAGCATTAATGCAGTTTGCAGTTGCACAGAGGATTACCTGTCCTCAGGTCCTGATACAGAAACATCTGGTTCGTC TTCTATCAGTTGTTCTTCCTAACATAAAATCAGAAGATACACCATGCCTTCTGTCTATAGATCTGTTTCATGTTTTGGTGGGTGCTGTGT TAGCATTCCCATCCTTGTATTGGGATGACCCTGTTGATCTGCAGCCTTCTTCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCATT TGATCACCATGGCACACATGCTTCAGATACTACTTACAGTAGACACAGGCCTACCCCTTGCTCAGGTTCAAGAAGACAGTGAAGAGGCTC ATTCCGCATCTTCTTTCTTTGCAGAAATTTCTCAATATACAAGTGGCTCCATTGGGTGTGATATTCCTGGCTGGTATTTGTGGGTCTCAC TGAAGAATGGCATCACCCCTTATCTTCGCTGTGCTGCATTGTTTTTCCACTATTTACTTGGGGTAACTCCGCCTGAGGAACTGCATACCA ATTCTGCAGAAGGAGAGTACAGTGCACTCTGTAGCTATCTATCTTTACCTACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACTG TAAGGCCCTTGCTCCAGAGGTGGTGTGCAGATCCTGCCTTACTAAACTGTTTGAAGCAAAAAAACACCGTGGTCAGGTACCCTAGAAAAA GAAATAGTTTGATAGAGCTTCCTGATGACTATAGCTGCCTCCTGAATCAAGCTTCTCATTTCAGGTGCCCACGGTCTGCAGATGATGAGC GAAAGCATCCTGTCCTCTGCCTTTTCTGTGGGGCTATACTATGTTCTCAGAACATTTGCTGCCAGGAAATTGTGAACGGGGAAGAGGTTG GAGCTTGCATTTTTCACGCACTTCACTGTGGAGCCGGAGTCTGCATTTTCCTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGTA AAGCCAGAGGCTGTGCCTATCCAGCTCCTTACTTGGATGAATATGGAGAAACAGACCCTGGCCTGAAGAGGGGCAACCCCCTTCATTTAT CTCGTGAGCGGTATCGGAAGCTCCATTTGGTCTGGCAACAACACTGCATTATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATGT TATTTGGATTCAACTGGCAGTTACTGTGAGCTCCAACTCTGCCTCAAGACAATCACAAATGACGACAGTAGTAAAGGCTGATTCAAAATT ATGGAAAACTTTCTGAGGGCTGGGAAAGTATTGGAGGGTCTTTTGCTCCATGTCCAGGTTCACTTACATCAATAAAATATTTCTTAATGG AGTATTGCTTTCAATTAGCAAACATATGCTTCACAGGAAAAAAGGACATAGATCAATCTGTTTTATGTGCTAGTATTTCCAGGAATTTAT TCCCCTTCATAATTTGTCTCATTTCATTTTATTTCATCCACTTGGTAGATGAAGTCACGTCAAACAGTTGTAGACATTTTATATGTTGGT TAACTCTTCTGCAATTTTGTATTTGGTGTTTTCCCCCCAAGTTTAGTTCAACTGACATTGGATCACTGACAAAATTCTAATAATCTGTGA TAGTCTTCCTTGCAGTTAAAGAAGAATTGCAGAAACCATGCAATATACTTGGGAAAGATTCCAAAAATAAATTTTTTATTATTTCTCTTT TAAGGAAATACCCCTAATGTGCCACCTGCTGCTATCACCACAAATTAAACTCAATCTCTATGTGGACAGAGGATGATTTCTGCCAATATG GAAAAGCTTTTTTCTCACTGTAGGCCTCAAGAAAAGTTAGGGTAATGTATTTGTTATTCATTCCTGACGGTACAAAGAGCTTGCAGTTCT CACCTCTGACTACCAGTAGCTTTGTTGAGTTTTGAAATAATACTTGACATTTTCCAAAGGCAAATCTCATTCTGCAAGGAGATTGTGGCA CCATCCTGTTTGACTCTCAGAAACCTCTTGTAATTCTGATGTAAAAACTGTAGAATGAAGATGAGAAAATTCTCGCAATGAGTGGATCAT GACAACTGTAAATTAGAACAATCAGATTTAAACCAATTCCGCAGTCTTCTATATCTTTGTAAAAGACAAATCCTTGATGTTGTCTGTGTG CAACCTTTTCATAAACTCTGGTTTTATGACTAGTACAAACCACCAAAAAAGCCATGTGATCAATAGTCTGTGTCCTGTTATAACATGCTG TGGTTGAGCCATCTTGTTTATAAATAATAGAGCTCTCCTGAATTTGTGCATAGACTTCTTGGTTCCTGGCTTTTGTTTTTTGTATCAAGA GATTGTGATATAAAACAGCAGAAGATAAATGGAAACCTTCCATTTTAACTTACGTTGTTTCTGGGGTAATGTTAGAACCTTGAAAGATGC ATTCAAAGACTGTATCTTATTTTGCCCTTGGCTATTAGTGTCTCACATATGTGTGTAAATGTTTTCCTACCTTCTTTTTGCTCAGCAAAG GCAAGCAAGTAAAATATATTTGCTAAGTGATTAGTGATGCACATTTGGGGCTAGATTTTTTTGGTACTTTTATGTAAAGAAAAGTGGATT TTGCAGTAAGGGATTGGCATGAGCAGGCGTCAGAATCACAATCATGATTTTCTACTTGAATAATTACAATTCAGAAGGTATCTGGATAAA TAGATACATGTCTAGTGAACAATTTGTAACAATAACAGGTAAGGATCAGGAAATTCAGTATTCAGTTTGTCAGATTTGCCAGAATGATGA AAGTATTTGAACATGTGTGTTTGTTTCTTATATAATTGTATTGAGTGGATTGTTTGACTGGGAAATCTGGGCTAGAATAGGAAACAGAAG ATACTGACTTCTACCCTAATAGATGGGCCCCAATTTAGCAAAGATAAACTGACTTTATTTTTAGTCCTTTTTATATTAACTTAATAAATT CTGGAGTTAGGCTCTCAAGAGGACAGAGGGACTGTCTGGCAATGGCCAGCCAGACCTTTACTGCCAAAGAACCCATTTCATATTGCGTTC CACTGATTGAGATTGATTCAGATTTTTGCACTGTAGATGAGCGTATGTCTCAGTGCTGCCCCAAGCCCCAGGGATTTCTCATTATGTTCA AATGTCCTAGTGATTTACCTTAATCATTGCAAACAATTATGCTTATGAAGTTTACTTACAAACAAGCAACTGAGTCACTTTATTTTCTTT AGTGTAGTATGTGAAGGCACTGGTTCAACAGGATGGCTCCAGAACTGTGTTTTTCTAATGTTTGGTAAGGGGCTAGTGAGAATTTTAATG ATATGGTGAAGAAAAATATATCTGTATAATTAATTTATTATATTGGTGTATGGGCTGTGAGTTCACCTTTTAGTGGTCATTTGTCATTTC ATAACAACTATGCATTTTGGTTCACTGTGATGATGATCTATATTTAGTGACTGCAACATGTTTATACCACTGATTCAAATTCCATCCATG ATGAAGTTATACAAATAATGCATATATTGATAACTTTTATTGCAAAAATGTAAATTTAAAACTTGTATAATGTTCTTGTGCTTTTTAAAA >70205_70205_3_PTPN12-UBR1_PTPN12_chr7_77230123_ENST00000435495_UBR1_chr15_43294902_ENST00000290650_length(amino acids)=742AA_BP=161 MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP FKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCRYFEAVQLSSQQRIHVDL FDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIFFNQGMGDSTLEFHSILS FGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPMLTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRI TCPQVLIQKHLVRLLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFHLITMAHMLQILLTVDTG LPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVSLKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLP TNLFLLFQEYWDTVRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQ NICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCI -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for PTPN12-UBR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000248594 | + | 8 | 18 | 345_438 | 231.66666666666666 | 781.0 | TGFB1I1 |
| Hgene | PTPN12 | chr7:77230123 | chr15:43294902 | ENST00000435495 | + | 7 | 17 | 345_438 | 101.66666666666667 | 651.0 | TGFB1I1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for PTPN12-UBR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for PTPN12-UBR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies