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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPN14-MARK3 (FusionGDB2 ID:70219)

Fusion Gene Summary for PTPN14-MARK3

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN14-MARK3
Fusion gene ID: 70219
HgeneTgene
Gene symbol

PTPN14

MARK3

Gene ID

5784

4140

Gene nameprotein tyrosine phosphatase non-receptor type 14microtubule affinity regulating kinase 3
SynonymsCATLPH|PEZ|PTP36CTAK1|KP78|PAR1A|Par-1a|VIPB
Cytomap

1q32.3-q41

14q32.32-q32.33

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 14cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase pezMAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
Modification date2020031320200313
UniProtAcc.

P27448

Ensembl transtripts involved in fusion geneENST00000366956, ENST00000543945, 
ENST00000491277, 		ENST00000561071, 
ENST00000216288, ENST00000303622, 
ENST00000335102, ENST00000416682, 
ENST00000429436, ENST00000440884, 
ENST00000553942, 
Fusion gene scores* DoF score9 X 11 X 5=49516 X 19 X 9=2736
# samples 1121
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2736*10)=-3.70360699721978
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN14 [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPN14(214637972)-MARK3(103928741), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPN14-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPN14-MARK3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PTPN14-MARK3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPN14-MARK3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN14

GO:0046825

regulation of protein export from nucleus

22948661

TgeneMARK3

GO:0018105

peptidyl-serine phosphorylation

9543386

TgeneMARK3

GO:0032092

positive regulation of protein binding

9543386

TgeneMARK3

GO:0035331

negative regulation of hippo signaling

28087714

TgeneMARK3

GO:0036289

peptidyl-serine autophosphorylation

9543386


check buttonFusion gene breakpoints across PTPN14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2297PTPN14chr1

214637972

-MARK3chr14

103928741

+


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Fusion Gene ORF analysis for PTPN14-MARK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000366956ENST00000561071PTPN14chr1

214637972

-MARK3chr14

103928741

+
5CDS-intronENST00000543945ENST00000561071PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000216288PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000303622PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000335102PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000416682PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000429436PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000440884PTPN14chr1

214637972

-MARK3chr14

103928741

+
Frame-shiftENST00000366956ENST00000553942PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000216288PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000303622PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000335102PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000416682PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000429436PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000440884PTPN14chr1

214637972

-MARK3chr14

103928741

+
In-frameENST00000543945ENST00000553942PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000216288PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000303622PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000335102PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000416682PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000429436PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000440884PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-3CDSENST00000491277ENST00000553942PTPN14chr1

214637972

-MARK3chr14

103928741

+
intron-intronENST00000491277ENST00000561071PTPN14chr1

214637972

-MARK3chr14

103928741

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543945PTPN14chr1214637972-ENST00000440884MARK3chr14103928741+169617401670556
ENST00000543945PTPN14chr1214637972-ENST00000416682MARK3chr14103928741+201417401880626
ENST00000543945PTPN14chr1214637972-ENST00000429436MARK3chr14103928741+255217401952650
ENST00000543945PTPN14chr1214637972-ENST00000303622MARK3chr14103928741+248517401880626
ENST00000543945PTPN14chr1214637972-ENST00000216288MARK3chr14103928741+243217401832610
ENST00000543945PTPN14chr1214637972-ENST00000553942MARK3chr14103928741+194417401925641
ENST00000543945PTPN14chr1214637972-ENST00000335102MARK3chr14103928741+195317401952650

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543945ENST00000440884PTPN14chr1214637972-MARK3chr14103928741+0.0045276590.9954724
ENST00000543945ENST00000416682PTPN14chr1214637972-MARK3chr14103928741+0.0072309320.9927691
ENST00000543945ENST00000429436PTPN14chr1214637972-MARK3chr14103928741+0.0026873760.9973126
ENST00000543945ENST00000303622PTPN14chr1214637972-MARK3chr14103928741+0.0025881150.9974119
ENST00000543945ENST00000216288PTPN14chr1214637972-MARK3chr14103928741+0.0027220230.99727803
ENST00000543945ENST00000553942PTPN14chr1214637972-MARK3chr14103928741+0.0098046210.99019533
ENST00000543945ENST00000335102PTPN14chr1214637972-MARK3chr14103928741+0.0090971720.99090284

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Fusion Genomic Features for PTPN14-MARK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPN14chr1214637972-MARK3chr14103928741+1.01E-070.9999999
PTPN14chr1214637972-MARK3chr14103928741+1.01E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTPN14-MARK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:214637972/chr14:103928741)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MARK3

P27448

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). {ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARK3chr1:214637972chr14:103928741ENST00000216288516326_365161714.0DomainUBA
TgeneMARK3chr1:214637972chr14:103928741ENST00000216288516704_753161714.0DomainKA1
TgeneMARK3chr1:214637972chr14:103928741ENST00000303622516326_365161730.0DomainUBA
TgeneMARK3chr1:214637972chr14:103928741ENST00000303622516704_753161730.0DomainKA1
TgeneMARK3chr1:214637972chr14:103928741ENST00000416682617326_365184753.0DomainUBA
TgeneMARK3chr1:214637972chr14:103928741ENST00000416682617704_753184753.0DomainKA1
TgeneMARK3chr1:214637972chr14:103928741ENST00000429436518326_365161754.0DomainUBA
TgeneMARK3chr1:214637972chr14:103928741ENST00000429436518704_753161754.0DomainKA1
TgeneMARK3chr1:214637972chr14:103928741ENST00000440884516326_365161660.0DomainUBA
TgeneMARK3chr1:214637972chr14:103928741ENST00000440884516704_753161660.0DomainKA1
TgeneMARK3chr1:214637972chr14:103928741ENST00000553942517326_365161745.0DomainUBA
TgeneMARK3chr1:214637972chr14:103928741ENST00000553942517704_753161745.0DomainKA1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN14chr1:214637972chr14:103928741ENST00000366956-219566_573581188.0Compositional biasNote=Poly-Pro
HgenePTPN14chr1:214637972chr14:103928741ENST00000366956-219709_716581188.0Compositional biasNote=Poly-Glu
HgenePTPN14chr1:214637972chr14:103928741ENST00000366956-21921_306581188.0DomainFERM
HgenePTPN14chr1:214637972chr14:103928741ENST00000366956-219909_1180581188.0DomainTyrosine-protein phosphatase
HgenePTPN14chr1:214637972chr14:103928741ENST00000366956-2191121_1127581188.0RegionSubstrate binding
TgeneMARK3chr1:214637972chr14:103928741ENST0000021628851656_307161714.0DomainProtein kinase
TgeneMARK3chr1:214637972chr14:103928741ENST0000030362251656_307161730.0DomainProtein kinase
TgeneMARK3chr1:214637972chr14:103928741ENST0000041668261756_307184753.0DomainProtein kinase
TgeneMARK3chr1:214637972chr14:103928741ENST0000042943651856_307161754.0DomainProtein kinase
TgeneMARK3chr1:214637972chr14:103928741ENST0000044088451656_307161660.0DomainProtein kinase
TgeneMARK3chr1:214637972chr14:103928741ENST0000055394251756_307161745.0DomainProtein kinase
TgeneMARK3chr1:214637972chr14:103928741ENST0000021628851662_70161714.0Nucleotide bindingATP
TgeneMARK3chr1:214637972chr14:103928741ENST0000030362251662_70161730.0Nucleotide bindingATP
TgeneMARK3chr1:214637972chr14:103928741ENST0000041668261762_70184753.0Nucleotide bindingATP
TgeneMARK3chr1:214637972chr14:103928741ENST0000042943651862_70161754.0Nucleotide bindingATP
TgeneMARK3chr1:214637972chr14:103928741ENST0000044088451662_70161660.0Nucleotide bindingATP
TgeneMARK3chr1:214637972chr14:103928741ENST0000055394251762_70161745.0Nucleotide bindingATP


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Fusion Gene Sequence for PTPN14-MARK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70219_70219_1_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000216288_length(transcript)=2432nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGCTGAAAATCTATTGTTAGATGCCGATATGAACATTAAA
ATAGCAGATTTCGGTTTTAGCAATGAATTTACTGTTGGCGGTAAACTCGACACGTTTTGTGGCAGTCCTCCATACGCAGCACCTGAGCTC
TTCCAGGGCAAGAAATATGACGGGCCAGAAGTGGATGTGTGGAGTCTGGGGGTCATTTTATACACACTAGTCAGTGGCTCACTTCCCTTT
GATGGGCAAAACCTAAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATTCCCTTCTACATGTCTACAGACTGTGAAAACCTT
CTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATGAAGGACAGGTGGATCAATGCAGGGCATGAAGAA
GATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATAGATATTATGGTGGGAATGGGATATTCACAAGAA
GAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTGTTATTGGGGAGAAAATCTTCAGAGGTTAGGCCG
AGCAGTGATCTCAACAACAGTACTGGCCAGTCTCCTCACCACAAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGT
GACCATGCTGGACCAGCTATTCCTTCTGTTGTGGCGTATCCGAAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGA
ATTTCCTCCCGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAGGGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAAT
AAGGCGGATATTCCTGAACGCAAGAAAAGCTCCACTGTCCCTAGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTT
TGCAGTGAGAGAACTACAGCTGATAGACACTCAGTGATTCAGAATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCT
TCAACACACAGTATCAGTAGTGCAGCCACCCCAGATCGAATCCGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCC
CGGGAACGGCGAACCGCAACATATAATGGCCCTCCTGCCTCTCCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGA
GGCTCCACTAATCTCTTTAGTAAATTAACTTCAAAACTCACAAGGAGTCGCAATGTATCTGCTGAGCAAAAAGATGAAAACAAAGAAGCA
AAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACTAGTTCAATGGATCCCGGGGACATGATGCGGGAAATCCGCAAAGTGTTG
GACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTGCTCTTCTGCGTCCACGGAGATGGGCACGCGGAGAACCTCGTGCAGTGG
GAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGGGTCCGGTTTAAGCGGATATCGGGGACATCCATAGCCTTCAAAAATATT
GCTTCCAAAATTGCCAATGAGCTAAAGCTGTAACCCAGTGATTATGATGTAAATTAAGTAGCAATTAAAGTGTTTTCCTGAACACTGATG
GAAATGTATAGAATAATATTTAGGCAATAACGTCTGCATCTTCTAAATCATGAAATTAAAGTCTGAGGACGAGAGCACGCCTGGGAGCGA
AAGCTGGCCTTTTTTCTACGAATGCACTACATTAAAGATGTGCAACCTATGCGCCCCCTGCCCTACTTCCGTTACCCTGAGAGTCGGTGT
GTGGCCCCATCTCCATGTGCCTCCCGTCTGGGTGGGTGTGAGAGTGGACGGTATGTGTGTGAAGTGGTGTATATGGAAGCATCTCCCTAC
ACTGGCAGCCAGTCATTACTAGTACCTCTGCGGGAGATCATCCGGTGCTAAAACATTACAGTTGCCAAGGAGGAAAATACTGAATGACTG
CTAAGAATTAACCTTAAGACCAGTTCATAGTTAATACAGGTTTACAGTTCATGCCTGTGGTTTTGTGTTTGTTGTTTTGTGTTTTTTTAG
TGCAAAAGGTTTAAATTTATAGTTGTGAACATTGCTTGTGTGTGTTTTTCTAAGTAGATTCACAAGATAATTAAAAATTCACTTTTTCTC

>70219_70219_1_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000216288_length(amino acids)=610AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKAENLLLDADMNIK
IADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL
LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSEVRP
SSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPN
KADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQP
RERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVL

--------------------------------------------------------------
>70219_70219_2_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000303622_length(transcript)=2485nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGCTGAAAATCTATTGTTAGATGCCGATATGAACATTAAA
ATAGCAGATTTCGGTTTTAGCAATGAATTTACTGTTGGCGGTAAACTCGACACGTTTTGTGGCAGTCCTCCATACGCAGCACCTGAGCTC
TTCCAGGGCAAGAAATATGACGGGCCAGAAGTGGATGTGTGGAGTCTGGGGGTCATTTTATACACACTAGTCAGTGGCTCACTTCCCTTT
GATGGGCAAAACCTAAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATTCCCTTCTACATGTCTACAGACTGTGAAAACCTT
CTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATGAAGGACAGGTGGATCAATGCAGGGCATGAAGAA
GATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATAGATATTATGGTGGGAATGGGATATTCACAAGAA
GAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTGTTATTGGGGAGAAAATCTTCAGAGCTGGATGCT
AGTGATTCCAGTTCTAGCAGCAATCTTTCACTTGCTAAGGTTAGGCCGAGCAGTGATCTCAACAACAGTACTGGCCAGTCTCCTCACCAC
AAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGTGACCATGCTGGACCAGCTATTCCTTCTGTTGTGGCGTATCCG
AAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGAATTTCCTCCCGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAG
GGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAATAAGGCGGATATTCCTGAACGCAAGAAAAGCTCCACTGTCCCT
AGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTTTGCAGTGAGAGAACTACAGCTGATAGACACTCAGTGATTCAG
AATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCTTCAACACACAGTATCAGTAGTGCAGCCACCCCAGATCGAATC
CGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCCCGGGAACGGCGAACCGCAACATATAATGGCCCTCCTGCCTCT
CCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGAGGCTCCACTAATCTCTTTAGTAAATTAACTTCAAAACTCACA
AGGAGTCGCAATGTATCTGCTGAGCAAAAAGATGAAAACAAAGAAGCAAAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACT
AGTTCAATGGATCCCGGGGACATGATGCGGGAAATCCGCAAAGTGTTGGACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTG
CTCTTCTGCGTCCACGGAGATGGGCACGCGGAGAACCTCGTGCAGTGGGAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGG
GTCCGGTTTAAGCGGATATCGGGGACATCCATAGCCTTCAAAAATATTGCTTCCAAAATTGCCAATGAGCTAAAGCTGTAACCCAGTGAT
TATGATGTAAATTAAGTAGCAATTAAAGTGTTTTCCTGAACACTGATGGAAATGTATAGAATAATATTTAGGCAATAACGTCTGCATCTT
CTAAATCATGAAATTAAAGTCTGAGGACGAGAGCACGCCTGGGAGCGAAAGCTGGCCTTTTTTCTACGAATGCACTACATTAAAGATGTG
CAACCTATGCGCCCCCTGCCCTACTTCCGTTACCCTGAGAGTCGGTGTGTGGCCCCATCTCCATGTGCCTCCCGTCTGGGTGGGTGTGAG
AGTGGACGGTATGTGTGTGAAGTGGTGTATATGGAAGCATCTCCCTACACTGGCAGCCAGTCATTACTAGTACCTCTGCGGGAGATCATC
CGGTGCTAAAACATTACAGTTGCCAAGGAGGAAAATACTGAATGACTGCTAAGAATTAACCTTAAGACCAGTTCATAGTTAATACAGGTT
TACAGTTCATGCCTGTGGTTTTGTGTTTGTTGTTTTGTGTTTTTTTAGTGCAAAAGGTTTAAATTTATAGTTGTGAACATTGCTTGTGTG

>70219_70219_2_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000303622_length(amino acids)=626AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKAENLLLDADMNIK
IADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL
LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDA
SDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGK
GIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRI
RFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTT

--------------------------------------------------------------
>70219_70219_3_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000335102_length(transcript)=1953nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGCTGAAAATCTATTGTTAGATGCCGATATGAACATTAAA
ATAGCAGATTTCGGTTTTAGCAATGAATTTACTGTTGGCGGTAAACTCGACACGTTTTGTGGCAGTCCTCCATACGCAGCACCTGAGCTC
TTCCAGGGCAAGAAATATGACGGGCCAGAAGTGGATGTGTGGAGTCTGGGGGTCATTTTATACACACTAGTCAGTGGCTCACTTCCCTTT
GATGGGCAAAACCTAAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATTCCCTTCTACATGTCTACAGACTGTGAAAACCTT
CTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATGAAGGACAGGTGGATCAATGCAGGGCATGAAGAA
GATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATAGATATTATGGTGGGAATGGGATATTCACAAGAA
GAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTGTTATTGGGGAGAAAATCTTCAGAGCTGGATGCT
AGTGATTCCAGTTCTAGCAGCAATCTTTCACTTGCTAAGGTTAGGCCGAGCAGTGATCTCAACAACAGTACTGGCCAGTCTCCTCACCAC
AAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGTGACCATGCTGGACCAGCTATTCCTTCTGTTGTGGCGTATCCG
AAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGAATTTCCTCCCGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAG
GGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAATAAGGCGGATATTCCTGAACGCAAGAAAAGCTCCACTGTCCCT
AGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTTTGCAGTGAGAGAACTACAGCTGATAGACACTCAGTGATTCAG
AATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCTTCAACACACAGTATCAGTAGTGCAGCCACCCCAGATCGAATC
CGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCCCGGGAACGGCGAACCGCAACATATAATGGCCCTCCTGCCTCT
CCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGAGGCTCCACTAATCTCTTTAGTAAATTAACTTCAAAACTCACA
AGGAGAAACATGTCATTCAGGTTTATCAAAAGGCTTCCAACTGAATATGAGAGGAACGGGAGATATGAGGGCTCAAGTCGCAATGTATCT
GCTGAGCAAAAAGATGAAAACAAAGAAGCAAAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACTAGTTCAATGGATCCCGGG
GACATGATGCGGGAAATCCGCAAAGTGTTGGACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTGCTCTTCTGCGTCCACGGA
GATGGGCACGCGGAGAACCTCGTGCAGTGGGAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGGGTCCGGTTTAAGCGGATA

>70219_70219_3_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000335102_length(amino acids)=650AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKAENLLLDADMNIK
IADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL
LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDA
SDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGK
GIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRI
RFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVS
AEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRI

--------------------------------------------------------------
>70219_70219_4_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000416682_length(transcript)=2014nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGCTGAAAATCTATTGTTAGATGCCGATATGAACATTAAA
ATAGCAGATTTCGGTTTTAGCAATGAATTTACTGTTGGCGGTAAACTCGACACGTTTTGTGGCAGTCCTCCATACGCAGCACCTGAGCTC
TTCCAGGGCAAGAAATATGACGGGCCAGAAGTGGATGTGTGGAGTCTGGGGGTCATTTTATACACACTAGTCAGTGGCTCACTTCCCTTT
GATGGGCAAAACCTAAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATTCCCTTCTACATGTCTACAGACTGTGAAAACCTT
CTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATGAAGGACAGGTGGATCAATGCAGGGCATGAAGAA
GATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATAGATATTATGGTGGGAATGGGATATTCACAAGAA
GAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTGTTATTGGGGAGAAAATCTTCAGAGCTGGATGCT
AGTGATTCCAGTTCTAGCAGCAATCTTTCACTTGCTAAGGTTAGGCCGAGCAGTGATCTCAACAACAGTACTGGCCAGTCTCCTCACCAC
AAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGTGACCATGCTGGACCAGCTATTCCTTCTGTTGTGGCGTATCCG
AAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGAATTTCCTCCCGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAG
GGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAATAAGGCGGATATTCCTGAACGCAAGAAAAGCTCCACTGTCCCT
AGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTTTGCAGTGAGAGAACTACAGCTGATAGACACTCAGTGATTCAG
AATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCTTCAACACACAGTATCAGTAGTGCAGCCACCCCAGATCGAATC
CGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCCCGGGAACGGCGAACCGCAACATATAATGGCCCTCCTGCCTCT
CCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGAGGCTCCACTAATCTCTTTAGTAAATTAACTTCAAAACTCACA
AGGAGTCGCAATGTATCTGCTGAGCAAAAAGATGAAAACAAAGAAGCAAAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACT
AGTTCAATGGATCCCGGGGACATGATGCGGGAAATCCGCAAAGTGTTGGACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTG
CTCTTCTGCGTCCACGGAGATGGGCACGCGGAGAACCTCGTGCAGTGGGAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGG
GTCCGGTTTAAGCGGATATCGGGGACATCCATAGCCTTCAAAAATATTGCTTCCAAAATTGCCAATGAGCTAAAGCTGTAACCCAGTGAT
TATGATGTAAATTAAGTAGCAATTAAAGTGTTTTCCTGAACACTGATGGAAATGTATAGAATAATATTTAGGCAATAACGTCTGCATCTT

>70219_70219_4_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000416682_length(amino acids)=626AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKAENLLLDADMNIK
IADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL
LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDA
SDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGK
GIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRI
RFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTT

--------------------------------------------------------------
>70219_70219_5_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000429436_length(transcript)=2552nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGCTGAAAATCTATTGTTAGATGCCGATATGAACATTAAA
ATAGCAGATTTCGGTTTTAGCAATGAATTTACTGTTGGCGGTAAACTCGACACGTTTTGTGGCAGTCCTCCATACGCAGCACCTGAGCTC
TTCCAGGGCAAGAAATATGACGGGCCAGAAGTGGATGTGTGGAGTCTGGGGGTCATTTTATACACACTAGTCAGTGGCTCACTTCCCTTT
GATGGGCAAAACCTAAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATTCCCTTCTACATGTCTACAGACTGTGAAAACCTT
CTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATGAAGGACAGGTGGATCAATGCAGGGCATGAAGAA
GATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATAGATATTATGGTGGGAATGGGATATTCACAAGAA
GAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTGTTATTGGGGAGAAAATCTTCAGAGCTGGATGCT
AGTGATTCCAGTTCTAGCAGCAATCTTTCACTTGCTAAGGTTAGGCCGAGCAGTGATCTCAACAACAGTACTGGCCAGTCTCCTCACCAC
AAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGTGACCATGCTGGACCAGCTATTCCTTCTGTTGTGGCGTATCCG
AAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGAATTTCCTCCCGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAG
GGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAATAAGGCGGATATTCCTGAACGCAAGAAAAGCTCCACTGTCCCT
AGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTTTGCAGTGAGAGAACTACAGCTGATAGACACTCAGTGATTCAG
AATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCTTCAACACACAGTATCAGTAGTGCAGCCACCCCAGATCGAATC
CGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCCCGGGAACGGCGAACCGCAACATATAATGGCCCTCCTGCCTCT
CCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGAGGCTCCACTAATCTCTTTAGTAAATTAACTTCAAAACTCACA
AGGAGAAACATGTCATTCAGGTTTATCAAAAGGCTTCCAACTGAATATGAGAGGAACGGGAGATATGAGGGCTCAAGTCGCAATGTATCT
GCTGAGCAAAAAGATGAAAACAAAGAAGCAAAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACTAGTTCAATGGATCCCGGG
GACATGATGCGGGAAATCCGCAAAGTGTTGGACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTGCTCTTCTGCGTCCACGGA
GATGGGCACGCGGAGAACCTCGTGCAGTGGGAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGGGTCCGGTTTAAGCGGATA
TCGGGGACATCCATAGCCTTCAAAAATATTGCTTCCAAAATTGCCAATGAGCTAAAGCTGTAACCCAGTGATTATGATGTAAATTAAGTA
GCAATTAAAGTGTTTTCCTGAACACTGATGGAAATGTATAGAATAATATTTAGGCAATAACGTCTGCATCTTCTAAATCATGAAATTAAA
GTCTGAGGACGAGAGCACGCCTGGGAGCGAAAGCTGGCCTTTTTTCTACGAATGCACTACATTAAAGATGTGCAACCTATGCGCCCCCTG
CCCTACTTCCGTTACCCTGAGAGTCGGTGTGTGGCCCCATCTCCATGTGCCTCCCGTCTGGGTGGGTGTGAGAGTGGACGGTATGTGTGT
GAAGTGGTGTATATGGAAGCATCTCCCTACACTGGCAGCCAGTCATTACTAGTACCTCTGCGGGAGATCATCCGGTGCTAAAACATTACA
GTTGCCAAGGAGGAAAATACTGAATGACTGCTAAGAATTAACCTTAAGACCAGTTCATAGTTAATACAGGTTTACAGTTCATGCCTGTGG
TTTTGTGTTTGTTGTTTTGTGTTTTTTTAGTGCAAAAGGTTTAAATTTATAGTTGTGAACATTGCTTGTGTGTGTTTTTCTAAGTAGATT

>70219_70219_5_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000429436_length(amino acids)=650AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKAENLLLDADMNIK
IADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL
LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDA
SDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGK
GIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRI
RFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVS
AEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRI

--------------------------------------------------------------
>70219_70219_6_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000440884_length(transcript)=1696nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATT
CCCTTCTACATGTCTACAGACTGTGAAAACCTTCTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATG
AAGGACAGGTGGATCAATGCAGGGCATGAAGAAGATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATA
GATATTATGGTGGGAATGGGATATTCACAAGAAGAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTG
TTATTGGGGAGAAAATCTTCAGAGCTGGATGCTAGTGATTCCAGTTCTAGCAGCAATCTTTCACTTGCTAAGGTTAGGCCGAGCAGTGAT
CTCAACAACAGTACTGGCCAGTCTCCTCACCACAAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGTGACCATGCT
GGACCAGCTATTCCTTCTGTTGTGGCGTATCCGAAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGAATTTCCTCC
CGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAGGGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAATAAGGCGGAT
ATTCCTGAACGCAAGAAAAGCTCCACTGTCCCTAGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTTTGCAGTGAG
AGAACTACAGCTGATAGACACTCAGTGATTCAGAATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCTTCAACACAC
AGTATCAGTAGTGCAGCCACCCCAGATCGAATCCGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCCCGGGAACGG
CGAACCGCAACATATAATGGCCCTCCTGCCTCTCCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGAGGCTCCACT
AATCTCTTTAGTAAATTAACTTCAAAACTCACAAGGAGAAACATGTCATTCAGGTTTATCAAAAGTCGCAATGTATCTGCTGAGCAAAAA
GATGAAAACAAAGAAGCAAAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACTAGTTCAATGGATCCCGGGGACATGATGCGG
GAAATCCGCAAAGTGTTGGACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTGCTCTTCTGCGTCCACGGAGATGGGCACGCG
GAGAACCTCGTGCAGTGGGAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGGGTCCGGTTTAAGCGGATATCGGGGACATCC

>70219_70219_6_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000440884_length(amino acids)=556AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKELRERVLRGKYRI
PFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYL
LLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISS
RKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTH
SISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVSAEQK
DENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTS

--------------------------------------------------------------
>70219_70219_7_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000553942_length(transcript)=1944nt_BP=174nt
ATGCCTTTTGGTCTGAAGCTCCGCCGGACACGGCGCTACAACGTCCTGAGCAAGAACTGCTTTGTCACACGGATTCGCCTGCTGGACAGC
AATGTTATCGAGTGCACGCTGTCGGTGGAAAGCACAGGGCAAGAATGCCTGGAGGCTGTGGCCCAGAGGCTGGAGCTGCGAGAGATTGTG
TCTGCAGTTCAATACTGCCATCAGAAACGGATCGTACATCGAGACCTCAAGGCTGAAAATCTATTGTTAGATGCCGATATGAACATTAAA
ATAGCAGATTTCGGTTTTAGCAATGAATTTACTGTTGGCGGTAAACTCGACACGTTTTGTGGCAGTCCTCCATACGCAGCACCTGAGCTC
TTCCAGGGCAAGAAATATGACGGGCCAGAAGTGGATGTGTGGAGTCTGGGGGTCATTTTATACACACTAGTCAGTGGCTCACTTCCCTTT
GATGGGCAAAACCTAAAGGAACTGAGAGAGAGAGTATTAAGAGGGAAATACAGAATTCCCTTCTACATGTCTACAGACTGTGAAAACCTT
CTCAAACGTTTCCTGGTGCTAAATCCAATTAAACGCGGCACTCTAGAGCAAATCATGAAGGACAGGTGGATCAATGCAGGGCATGAAGAA
GATGAACTCAAACCATTTGTTGAACCAGAGCTAGACATCTCAGACCAAAAAAGAATAGATATTATGGTGGGAATGGGATATTCACAAGAA
GAAATTCAAGAATCTCTTAGTAAGATGAAATACGATGAAATCACAGCTACATATTTGTTATTGGGGAGAAAATCTTCAGAGCTGGATGCT
AGTGATTCCAGTTCTAGCAGCAATCTTTCACTTGCTAAGGTTAGGCCGAGCAGTGATCTCAACAACAGTACTGGCCAGTCTCCTCACCAC
AAAGTGCAGAGAAGTGTTTTTTCAAGCCAAAAGCAAAGACGCTACAGTGACCATGCTGGACCAGCTATTCCTTCTGTTGTGGCGTATCCG
AAAAGGAGTCAGACCAGCACTGCAGATAGTGACCTCAAAGAAGATGGAATTTCCTCCCGGAAATCAAGTGGCAGTGCTGTTGGAGGAAAG
GGAATTGCTCCAGCCAGTCCCATGCTTGGGAATGCAAGTAATCCTAATAAGGCGGATATTCCTGAACGCAAGAAAAGCTCCACTGTCCCT
AGTAGTAACACAGCATCTGGTGGAATGACACGACGAAATACTTATGTTTGCAGTGAGAGAACTACAGCTGATAGACACTCAGTGATTCAG
AATGGCAAAGAAAACAGCACTATTCCTGATCAGAGAACTCCAGTTGCTTCAACACACAGTATCAGTAGTGCAGCCACCCCAGATCGAATC
CGCTTCCCAAGAGGCACTGCCAGTCGTAGCACTTTCCACGGCCAGCCCCGGGAACGGCGAACCGCAACATATAATGGCCCTCCTGCCTCT
CCCAGCCTGTCCCATGAAGCCACACCATTGTCCCAGACTCGAAGCCGAGGCTCCACTAATCTCTTTAGTAAATTAACTTCAAAACTCACA
AGGAGGCTTCCAACTGAATATGAGAGGAACGGGAGATATGAGGGCTCAAGTCGCAATGTATCTGCTGAGCAAAAAGATGAAAACAAAGAA
GCAAAGCCTCGATCCCTACGCTTCACCTGGAGCATGAAAACCACTAGTTCAATGGATCCCGGGGACATGATGCGGGAAATCCGCAAAGTG
TTGGACGCCAATAACTGCGACTATGAGCAGAGGGAGCGCTTCTTGCTCTTCTGCGTCCACGGAGATGGGCACGCGGAGAACCTCGTGCAG
TGGGAAATGGAAGTGTGCAAGCTGCCAAGACTGTCTCTGAACGGGGTCCGGTTTAAGCGGATATCGGGGACATCCATAGCCTTCAAAAAT

>70219_70219_7_PTPN14-MARK3_PTPN14_chr1_214637972_ENST00000543945_MARK3_chr14_103928741_ENST00000553942_length(amino acids)=641AA_BP=58
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELREIVSAVQYCHQKRIVHRDLKAENLLLDADMNIK
IADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENL
LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDA
SDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGK
GIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRI
RFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKE
AKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PTPN14-MARK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPN14-MARK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPN14-MARK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource