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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPN1-P2RX4 (FusionGDB2 ID:70234)

Fusion Gene Summary for PTPN1-P2RX4

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN1-P2RX4
Fusion gene ID: 70234
HgeneTgene
Gene symbol

PTPN1

P2RX4

Gene ID

5770

5025

Gene nameprotein tyrosine phosphatase non-receptor type 1purinergic receptor P2X 4
SynonymsPTP1BP2X4|P2X4R
Cytomap

20q13.13

12q24.31

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1BP2X purinoceptor 4ATP receptorATP-gated cation channel proteinP2X receptor, subunit 4purinergic receptor P2X, ligand gated ion channel, 4purinergic receptor P2X4purinoceptor P2X4
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371621, ENST00000541713, 
ENST00000540930, ENST00000541532, 
ENST00000543171, ENST00000337233, 
ENST00000359949, 
Fusion gene scores* DoF score8 X 5 X 6=2404 X 6 X 3=72
# samples 105
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN1 [Title/Abstract] AND P2RX4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPN1(49127127)-P2RX4(121654937), # samples:3
Anticipated loss of major functional domain due to fusion event.PTPN1-P2RX4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPN1-P2RX4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PTPN1-P2RX4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN1

GO:0030100

regulation of endocytosis

21135139

HgenePTPN1

GO:0030968

endoplasmic reticulum unfolded protein response

22169477

HgenePTPN1

GO:0035335

peptidyl-tyrosine dephosphorylation

21135139

HgenePTPN1

GO:0061098

positive regulation of protein tyrosine kinase activity

21216966

HgenePTPN1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

21216966

TgeneP2RX4

GO:0007165

signal transduction

9016352

TgeneP2RX4

GO:0010524

positive regulation of calcium ion transport into cytosol

10969036

TgeneP2RX4

GO:0033198

response to ATP

9016352

TgeneP2RX4

GO:0034220

ion transmembrane transport

10515189

TgeneP2RX4

GO:0034405

response to fluid shear stress

10969036

TgeneP2RX4

GO:0050850

positive regulation of calcium-mediated signaling

10969036

TgeneP2RX4

GO:0051899

membrane depolarization

9016352

TgeneP2RX4

GO:0070588

calcium ion transmembrane transport

9016352

TgeneP2RX4

GO:0071318

cellular response to ATP

10515189

TgeneP2RX4

GO:0097190

apoptotic signaling pathway

17264311


check buttonFusion gene breakpoints across PTPN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across P2RX4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-5364-01APTPN1chr20

49127127

-P2RX4chr12

121654937

+
ChimerDB4HNSCTCGA-CN-5364-01APTPN1chr20

49127127

+P2RX4chr12

121654937

+
ChimerDB4HNSCTCGA-CN-5364PTPN1chr20

49127127

+P2RX4chr12

121654937

+
ChimerDB4HNSCTCGA-CN-5364PTPN1chr20

49127127

+P2RX4chr12

121659715

+
ChimerDB4HNSCTCGA-CN-5364PTPN1chr20

49127127

+P2RX4chr12

121659716

+


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Fusion Gene ORF analysis for PTPN1-P2RX4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000371621ENST00000540930PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5CDS-3UTRENST00000371621ENST00000540930PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5CDS-3UTRENST00000371621ENST00000540930PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5CDS-3UTRENST00000371621ENST00000541532PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5CDS-3UTRENST00000371621ENST00000541532PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5CDS-3UTRENST00000371621ENST00000541532PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5CDS-5UTRENST00000371621ENST00000543171PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5CDS-5UTRENST00000371621ENST00000543171PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5CDS-intronENST00000371621ENST00000543171PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5UTR-3CDSENST00000541713ENST00000337233PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5UTR-3CDSENST00000541713ENST00000337233PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5UTR-3CDSENST00000541713ENST00000337233PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5UTR-3CDSENST00000541713ENST00000359949PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5UTR-3CDSENST00000541713ENST00000359949PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5UTR-3CDSENST00000541713ENST00000359949PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5UTR-3UTRENST00000541713ENST00000540930PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5UTR-3UTRENST00000541713ENST00000540930PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5UTR-3UTRENST00000541713ENST00000540930PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5UTR-3UTRENST00000541713ENST00000541532PTPN1chr20

49127127

+P2RX4chr12

121654937

+
5UTR-3UTRENST00000541713ENST00000541532PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5UTR-3UTRENST00000541713ENST00000541532PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5UTR-5UTRENST00000541713ENST00000543171PTPN1chr20

49127127

+P2RX4chr12

121659715

+
5UTR-5UTRENST00000541713ENST00000543171PTPN1chr20

49127127

+P2RX4chr12

121659716

+
5UTR-intronENST00000541713ENST00000543171PTPN1chr20

49127127

+P2RX4chr12

121654937

+
Frame-shiftENST00000371621ENST00000337233PTPN1chr20

49127127

+P2RX4chr12

121654937

+
Frame-shiftENST00000371621ENST00000359949PTPN1chr20

49127127

+P2RX4chr12

121654937

+
In-frameENST00000371621ENST00000337233PTPN1chr20

49127127

+P2RX4chr12

121659715

+
In-frameENST00000371621ENST00000337233PTPN1chr20

49127127

+P2RX4chr12

121659716

+
In-frameENST00000371621ENST00000359949PTPN1chr20

49127127

+P2RX4chr12

121659715

+
In-frameENST00000371621ENST00000359949PTPN1chr20

49127127

+P2RX4chr12

121659716

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371621PTPN1chr2049127127+ENST00000337233P2RX4chr12121659715+1679237781121347
ENST00000371621PTPN1chr2049127127+ENST00000359949P2RX4chr12121659715+1643237781121347
ENST00000371621PTPN1chr2049127127+ENST00000337233P2RX4chr12121659716+1679237781121347
ENST00000371621PTPN1chr2049127127+ENST00000359949P2RX4chr12121659716+1643237781121347

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371621ENST00000337233PTPN1chr2049127127+P2RX4chr12121659715+0.0032375790.9967624
ENST00000371621ENST00000359949PTPN1chr2049127127+P2RX4chr12121659715+0.0029084880.99709153
ENST00000371621ENST00000337233PTPN1chr2049127127+P2RX4chr12121659716+0.0032375790.9967624
ENST00000371621ENST00000359949PTPN1chr2049127127+P2RX4chr12121659716+0.0029084880.99709153

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Fusion Genomic Features for PTPN1-P2RX4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPN1chr2049127127+P2RX4chr12121654936+1.75E-081
PTPN1chr2049127127+P2RX4chr12121659715+1.22E-121
PTPN1chr2049127127+P2RX4chr12121654936+1.75E-081
PTPN1chr2049127127+P2RX4chr12121654936+1.75E-081
PTPN1chr2049127127+P2RX4chr12121659715+1.22E-121
PTPN1chr2049127127+P2RX4chr12121654936+1.75E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTPN1-P2RX4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:49127127/chr12:121654937)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneP2RX4chr20:49127127chr12:121659715ENST00000337233112360_38894389.0Topological domainCytoplasmic
TgeneP2RX4chr20:49127127chr12:121659716ENST00000337233112360_38894389.0Topological domainCytoplasmic
TgeneP2RX4chr20:49127127chr12:121659715ENST00000337233112339_35994389.0TransmembraneHelical%3B Name%3D2
TgeneP2RX4chr20:49127127chr12:121659716ENST00000337233112339_35994389.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN1chr20:49127127chr12:121659715ENST00000371621+1103_27721436.0DomainTyrosine-protein phosphatase
HgenePTPN1chr20:49127127chr12:121659716ENST00000371621+1103_27721436.0DomainTyrosine-protein phosphatase
HgenePTPN1chr20:49127127chr12:121659715ENST00000371621+110215_22121436.0RegionSubstrate binding
HgenePTPN1chr20:49127127chr12:121659716ENST00000371621+110215_22121436.0RegionSubstrate binding
TgeneP2RX4chr20:49127127chr12:121659715ENST000003372331121_3394389.0Topological domainCytoplasmic
TgeneP2RX4chr20:49127127chr12:121659715ENST0000033723311255_33894389.0Topological domainExtracellular
TgeneP2RX4chr20:49127127chr12:121659716ENST000003372331121_3394389.0Topological domainCytoplasmic
TgeneP2RX4chr20:49127127chr12:121659716ENST0000033723311255_33894389.0Topological domainExtracellular
TgeneP2RX4chr20:49127127chr12:121659715ENST0000033723311234_5494389.0TransmembraneHelical%3B Name%3D1
TgeneP2RX4chr20:49127127chr12:121659716ENST0000033723311234_5494389.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for PTPN1-P2RX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70234_70234_1_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659715_ENST00000337233_length(transcript)=1679nt_BP=237nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGAGGAAAACTCCCTCTTCGTCATGACCAACGTG
ATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGC
TCTGCCGGCACCCACAGCAACGGAGTCTCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGGTGC
CCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTAT
CCCAAATTTAATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCC
TTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGACATGGCCGTGGAGGGAGGCATCATGGGCATC
CAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAG
CACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTAT
GGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACTG
CTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGACTCTACTATCGGGAGAAGAAATATAAATATGTG
GAAGATTACGAGCAGGGTCTTGCTAGTGAGCTGGACCAGTGAGGCCTACCCCACACCTGGGCTCTCCACAGCCCCATCAAAGAACAGAGA
GGAGGAGGAGGGAGAAATGGCCACCACATCACCCCAGAGAAATTTCTGGAATCTGATTGAGTCTCCACTCCACAAGCACTCAGGGTTCCC
CAGCAGCTCCTGTGTGTTGTGTGCAGGATCTGTTTGCCCACTCGGCCCAGGAGGTCAGCAGTCTGTTCTTGGCTGGGTCAACTCTGCTTT
TCCCGCAACCTGGGGTTGTCGGGGGAGCGCTGGCCCGACGCAGTGGCACTGCTGTGGCTTTCAGGGCTGGAGCTGGCTTTGCTCAGAAGC
CTCCTGTCTCCAGCTCTCTCCAGGACAGGCCCAGTCCTCTGAGGCACGGCGGCTCTGTTCAAGCACTTTATGCGGCAGGGGAGGCCGCCT
GGCTGCAGTCACTAGACTTGTAGCAGGCCTGGGCTGCAGGCTTCCCCCCGACCATTCCCTGCAGCCATGCGGCAGAGCTGGCATTTCTCC

>70234_70234_1_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659715_ENST00000337233_length(amino acids)=347AA_BP=52
MQRASGLRARRGLERQTAQWAEKEAQQPPWPVMEMEKEFEQIDKSGSWAAIYQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDAS
CTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDA
KTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTL

--------------------------------------------------------------
>70234_70234_2_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659715_ENST00000359949_length(transcript)=1643nt_BP=237nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGAGGAAAACTCCCTCTTCGTCATGACCAACGTG
ATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGC
TCTGCCGGCACCCACAGCAACGGAGTCTCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGGTGC
CCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTAT
CCCAAATTTAATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCC
TTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGACATGGCCGTGGAGGGAGGCATCATGGGCATC
CAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAG
CACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTAT
GGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACTG
CTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGACTCTACTATCGGGAGAAGAAATATAAATATGTG
GAAGATTACGAGCAGGGTCTTGCTAGTGAGCTGGACCAGTGAGGCCTACCCCACACCTGGGCTCTCCACAGCCCCATCAAAGAACAGAGA
GGAGGAGGAGGGAGAAATGGCCACCACATCACCCCAGAGAAATTTCTGGAATCTGATTGAGTCTCCACTCCACAAGCACTCAGGGTTCCC
CAGCAGCTCCTGTGTGTTGTGTGCAGGATCTGTTTGCCCACTCGGCCCAGGAGGTCAGCAGTCTGTTCTTGGCTGGGTCAACTCTGCTTT
TCCCGCAACCTGGGGTTGTCGGGGGAGCGCTGGCCCGACGCAGTGGCACTGCTGTGGCTTTCAGGGCTGGAGCTGGCTTTGCTCAGAAGC
CTCCTGTCTCCAGCTCTCTCCAGGACAGGCCCAGTCCTCTGAGGCACGGCGGCTCTGTTCAAGCACTTTATGCGGCAGGGGAGGCCGCCT
GGCTGCAGTCACTAGACTTGTAGCAGGCCTGGGCTGCAGGCTTCCCCCCGACCATTCCCTGCAGCCATGCGGCAGAGCTGGCATTTCTCC

>70234_70234_2_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659715_ENST00000359949_length(amino acids)=347AA_BP=52
MQRASGLRARRGLERQTAQWAEKEAQQPPWPVMEMEKEFEQIDKSGSWAAIYQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDAS
CTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDA
KTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTL

--------------------------------------------------------------
>70234_70234_3_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659716_ENST00000337233_length(transcript)=1679nt_BP=237nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGAGGAAAACTCCCTCTTCGTCATGACCAACGTG
ATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGC
TCTGCCGGCACCCACAGCAACGGAGTCTCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGGTGC
CCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTAT
CCCAAATTTAATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCC
TTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGACATGGCCGTGGAGGGAGGCATCATGGGCATC
CAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAG
CACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTAT
GGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACTG
CTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGACTCTACTATCGGGAGAAGAAATATAAATATGTG
GAAGATTACGAGCAGGGTCTTGCTAGTGAGCTGGACCAGTGAGGCCTACCCCACACCTGGGCTCTCCACAGCCCCATCAAAGAACAGAGA
GGAGGAGGAGGGAGAAATGGCCACCACATCACCCCAGAGAAATTTCTGGAATCTGATTGAGTCTCCACTCCACAAGCACTCAGGGTTCCC
CAGCAGCTCCTGTGTGTTGTGTGCAGGATCTGTTTGCCCACTCGGCCCAGGAGGTCAGCAGTCTGTTCTTGGCTGGGTCAACTCTGCTTT
TCCCGCAACCTGGGGTTGTCGGGGGAGCGCTGGCCCGACGCAGTGGCACTGCTGTGGCTTTCAGGGCTGGAGCTGGCTTTGCTCAGAAGC
CTCCTGTCTCCAGCTCTCTCCAGGACAGGCCCAGTCCTCTGAGGCACGGCGGCTCTGTTCAAGCACTTTATGCGGCAGGGGAGGCCGCCT
GGCTGCAGTCACTAGACTTGTAGCAGGCCTGGGCTGCAGGCTTCCCCCCGACCATTCCCTGCAGCCATGCGGCAGAGCTGGCATTTCTCC

>70234_70234_3_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659716_ENST00000337233_length(amino acids)=347AA_BP=52
MQRASGLRARRGLERQTAQWAEKEAQQPPWPVMEMEKEFEQIDKSGSWAAIYQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDAS
CTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDA
KTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTL

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>70234_70234_4_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659716_ENST00000359949_length(transcript)=1643nt_BP=237nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGAGGAAAACTCCCTCTTCGTCATGACCAACGTG
ATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGC
TCTGCCGGCACCCACAGCAACGGAGTCTCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGGTGC
CCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTAT
CCCAAATTTAATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCC
TTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGACATGGCCGTGGAGGGAGGCATCATGGGCATC
CAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAG
CACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTAT
GGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACTG
CTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGACTCTACTATCGGGAGAAGAAATATAAATATGTG
GAAGATTACGAGCAGGGTCTTGCTAGTGAGCTGGACCAGTGAGGCCTACCCCACACCTGGGCTCTCCACAGCCCCATCAAAGAACAGAGA
GGAGGAGGAGGGAGAAATGGCCACCACATCACCCCAGAGAAATTTCTGGAATCTGATTGAGTCTCCACTCCACAAGCACTCAGGGTTCCC
CAGCAGCTCCTGTGTGTTGTGTGCAGGATCTGTTTGCCCACTCGGCCCAGGAGGTCAGCAGTCTGTTCTTGGCTGGGTCAACTCTGCTTT
TCCCGCAACCTGGGGTTGTCGGGGGAGCGCTGGCCCGACGCAGTGGCACTGCTGTGGCTTTCAGGGCTGGAGCTGGCTTTGCTCAGAAGC
CTCCTGTCTCCAGCTCTCTCCAGGACAGGCCCAGTCCTCTGAGGCACGGCGGCTCTGTTCAAGCACTTTATGCGGCAGGGGAGGCCGCCT
GGCTGCAGTCACTAGACTTGTAGCAGGCCTGGGCTGCAGGCTTCCCCCCGACCATTCCCTGCAGCCATGCGGCAGAGCTGGCATTTCTCC

>70234_70234_4_PTPN1-P2RX4_PTPN1_chr20_49127127_ENST00000371621_P2RX4_chr12_121659716_ENST00000359949_length(amino acids)=347AA_BP=52
MQRASGLRARRGLERQTAQWAEKEAQQPPWPVMEMEKEFEQIDKSGSWAAIYQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDAS
CTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDA
KTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTL

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Fusion Gene PPI Analysis for PTPN1-P2RX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPN1-P2RX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPN1-P2RX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource