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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPN3-ASTN2 (FusionGDB2 ID:70274)

Fusion Gene Summary for PTPN3-ASTN2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN3-ASTN2
Fusion gene ID: 70274
HgeneTgene
Gene symbol

PTPN3

ASTN2

Gene ID

5774

23245

Gene nameprotein tyrosine phosphatase non-receptor type 3astrotactin 2
SynonymsPTP-H1|PTPH1bA67K19.1
Cytomap

9q31.3

9q33.1

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 3cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase H1astrotactin-2
Modification date2020031320200313
UniProtAcc.

O75129

Ensembl transtripts involved in fusion geneENST00000262539, ENST00000374541, 
ENST00000412145, ENST00000446349, 
ENST00000394827, ENST00000497739, 
ENST00000288520, ENST00000341734, 
ENST00000358637, ENST00000361209, 
ENST00000361477, ENST00000313400, 
ENST00000373996, 
Fusion gene scores* DoF score7 X 7 X 6=29420 X 19 X 8=3040
# samples 725
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3040*10)=-3.60407132366886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN3 [Title/Abstract] AND ASTN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPN3(112207520)-ASTN2(119903757), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN3

GO:0006470

protein dephosphorylation

10364224

HgenePTPN3

GO:0045930

negative regulation of mitotic cell cycle

10364224

HgenePTPN3

GO:0098902

regulation of membrane depolarization during action potential

16930557

HgenePTPN3

GO:2000649

regulation of sodium ion transmembrane transporter activity

16930557


check buttonFusion gene breakpoints across PTPN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASTN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A7OU-01BPTPN3chr9

112207520

-ASTN2chr9

119903757

-


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Fusion Gene ORF analysis for PTPN3-ASTN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262539ENST00000288520PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000262539ENST00000341734PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000262539ENST00000358637PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000262539ENST00000361209PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000262539ENST00000361477PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000374541ENST00000288520PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000374541ENST00000341734PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000374541ENST00000358637PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000374541ENST00000361209PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000374541ENST00000361477PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000412145ENST00000288520PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000412145ENST00000341734PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000412145ENST00000358637PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000412145ENST00000361209PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000412145ENST00000361477PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000446349ENST00000288520PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000446349ENST00000341734PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000446349ENST00000358637PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000446349ENST00000361209PTPN3chr9

112207520

-ASTN2chr9

119903757

-
5CDS-intronENST00000446349ENST00000361477PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000262539ENST00000313400PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000262539ENST00000373996PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000374541ENST00000313400PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000374541ENST00000373996PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000412145ENST00000313400PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000412145ENST00000373996PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000446349ENST00000313400PTPN3chr9

112207520

-ASTN2chr9

119903757

-
In-frameENST00000446349ENST00000373996PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-3CDSENST00000394827ENST00000313400PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-3CDSENST00000394827ENST00000373996PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-3CDSENST00000497739ENST00000313400PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-3CDSENST00000497739ENST00000373996PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000394827ENST00000288520PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000394827ENST00000341734PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000394827ENST00000358637PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000394827ENST00000361209PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000394827ENST00000361477PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000497739ENST00000288520PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000497739ENST00000341734PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000497739ENST00000358637PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000497739ENST00000361209PTPN3chr9

112207520

-ASTN2chr9

119903757

-
intron-intronENST00000497739ENST00000361477PTPN3chr9

112207520

-ASTN2chr9

119903757

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000412145PTPN3chr9112207520-ENST00000373996ASTN2chr9119903757-62462627251856191033
ENST00000412145PTPN3chr9112207520-ENST00000313400ASTN2chr9119903757-62582627251856311037
ENST00000446349PTPN3chr9112207520-ENST00000373996ASTN2chr9119903757-62462627251856191033
ENST00000446349PTPN3chr9112207520-ENST00000313400ASTN2chr9119903757-62582627251856311037
ENST00000374541PTPN3chr9112207520-ENST00000373996ASTN2chr9119903757-419057110535631152
ENST00000374541PTPN3chr9112207520-ENST00000313400ASTN2chr9119903757-420257110535751156
ENST00000262539PTPN3chr9112207520-ENST00000373996ASTN2chr9119903757-411549635734881043
ENST00000262539PTPN3chr9112207520-ENST00000313400ASTN2chr9119903757-412749635735001047

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000412145ENST00000373996PTPN3chr9112207520-ASTN2chr9119903757-0.0111684210.9888315
ENST00000412145ENST00000313400PTPN3chr9112207520-ASTN2chr9119903757-0.0073463480.9926536
ENST00000446349ENST00000373996PTPN3chr9112207520-ASTN2chr9119903757-0.0111684210.9888315
ENST00000446349ENST00000313400PTPN3chr9112207520-ASTN2chr9119903757-0.0073463480.9926536
ENST00000374541ENST00000373996PTPN3chr9112207520-ASTN2chr9119903757-0.0027255410.99727446
ENST00000374541ENST00000313400PTPN3chr9112207520-ASTN2chr9119903757-0.0023899560.9976101
ENST00000262539ENST00000373996PTPN3chr9112207520-ASTN2chr9119903757-0.0036242490.99637574
ENST00000262539ENST00000313400PTPN3chr9112207520-ASTN2chr9119903757-0.0032210550.996779

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Fusion Genomic Features for PTPN3-ASTN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPN3-ASTN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:112207520/chr9:119903757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASTN2

O75129

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). {ECO:0000250|UniProtKB:Q80Z10, ECO:0000269|Ref.6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASTN2chr9:112207520chr9:119903757ENST00000288520081065_11880441.0DomainNote=Fibronectin type-III
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008510_5500441.0DomainNote=EGF-like 1
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008651_6950441.0DomainNote=EGF-like 2
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008699_7510441.0DomainNote=EGF-like 3
TgeneASTN2chr9:112207520chr9:119903757ENST000003134002231065_11883381340.0DomainNote=Fibronectin type-III
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223510_5503381340.0DomainNote=EGF-like 1
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223651_6953381340.0DomainNote=EGF-like 2
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223699_7513381340.0DomainNote=EGF-like 3
TgeneASTN2chr9:112207520chr9:119903757ENST00000341734091065_11880396.0DomainNote=Fibronectin type-III
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409510_5500396.0DomainNote=EGF-like 1
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409651_6950396.0DomainNote=EGF-like 2
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409699_7510396.0DomainNote=EGF-like 3
TgeneASTN2chr9:112207520chr9:119903757ENST000003612090221065_118801289.0DomainNote=Fibronectin type-III
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022510_55001289.0DomainNote=EGF-like 1
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022651_69501289.0DomainNote=EGF-like 2
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022699_75101289.0DomainNote=EGF-like 3
TgeneASTN2chr9:112207520chr9:119903757ENST000003614770231065_11880396.0DomainNote=Fibronectin type-III
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023510_5500396.0DomainNote=EGF-like 1
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023651_6950396.0DomainNote=EGF-like 2
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023699_7510396.0DomainNote=EGF-like 3
TgeneASTN2chr9:112207520chr9:119903757ENST000003739962231065_11883381336.0DomainNote=Fibronectin type-III
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223510_5503381336.0DomainNote=EGF-like 1
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223651_6953381336.0DomainNote=EGF-like 2
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223699_7513381336.0DomainNote=EGF-like 3
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008228_4340441.0Topological domainCytoplasmic
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008456_13390441.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST000002885200850_2060441.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223456_13393381340.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409228_4340396.0Topological domainCytoplasmic
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409456_13390396.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST000003417340950_2060396.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022228_43401289.0Topological domainCytoplasmic
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022456_133901289.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST0000036120902250_20601289.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023228_4340396.0Topological domainCytoplasmic
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023456_13390396.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST0000036147702350_2060396.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223456_13393381336.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008207_2270441.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST0000028852008435_4550441.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223435_4553381340.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409207_2270396.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST0000034173409435_4550396.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022207_22701289.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000361209022435_45501289.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023207_2270396.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000361477023435_4550396.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223435_4553381336.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN3chr9:112207520chr9:119903757ENST00000374541-72629_312155914.0DomainFERM
HgenePTPN3chr9:112207520chr9:119903757ENST00000374541-726510_582155914.0DomainPDZ
HgenePTPN3chr9:112207520chr9:119903757ENST00000374541-726646_901155914.0DomainTyrosine-protein phosphatase
HgenePTPN3chr9:112207520chr9:119903757ENST00000412145-22129_31224783.0DomainFERM
HgenePTPN3chr9:112207520chr9:119903757ENST00000412145-221510_58224783.0DomainPDZ
HgenePTPN3chr9:112207520chr9:119903757ENST00000412145-221646_90124783.0DomainTyrosine-protein phosphatase
HgenePTPN3chr9:112207520chr9:119903757ENST00000446349-22029_31224738.0DomainFERM
HgenePTPN3chr9:112207520chr9:119903757ENST00000446349-220510_58224738.0DomainPDZ
HgenePTPN3chr9:112207520chr9:119903757ENST00000446349-220646_90124738.0DomainTyrosine-protein phosphatase
HgenePTPN3chr9:112207520chr9:119903757ENST00000374541-726842_848155914.0RegionSubstrate binding
HgenePTPN3chr9:112207520chr9:119903757ENST00000412145-221842_84824783.0RegionSubstrate binding
HgenePTPN3chr9:112207520chr9:119903757ENST00000446349-220842_84824738.0RegionSubstrate binding
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223228_4343381340.0Topological domainCytoplasmic
TgeneASTN2chr9:112207520chr9:119903757ENST0000031340022350_2063381340.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223228_4343381336.0Topological domainCytoplasmic
TgeneASTN2chr9:112207520chr9:119903757ENST0000037399622350_2063381336.0Topological domainLumenal
TgeneASTN2chr9:112207520chr9:119903757ENST00000313400223207_2273381340.0TransmembraneHelical
TgeneASTN2chr9:112207520chr9:119903757ENST00000373996223207_2273381336.0TransmembraneHelical


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Fusion Gene Sequence for PTPN3-ASTN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70274_70274_1_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000262539_ASTN2_chr9_119903757_ENST00000313400_length(transcript)=4127nt_BP=496nt
CTCAGACGGCGGCCAGGTCGCGCCGCGAGCGAGCTTCCGCGCCGCCCGCACGCGCGACCTACCTGGGCGCTCCGCGCCCCCGGATGCTGC
AGGTTATTCAGCGATAGTTATGACCTCCCGGTTACGTGCGTTGGGTGGAAGAATTAATAATATACGCACCTCGGAGTTACCCAAAGAGAA
AACTCGATCAGAAGTCATTTGCAGCATCCACTTTTTAGATGGCGTGGTACAGACCTTTAAAGTTACTAAACAAGACACTGGCCAGGTTCT
TCTGGATATGGTGCACAACCACCTGGGTGTGACTGAAAAGGAATATTTTGGTTTACAGCATGATGACGACTCCGTGGACTCTCCTAGATG
GCTGGAAGCAAGCAAAGCCATCAGGAAGCAGTTAAAAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACC
TGCCCTCTTAACTCAGCAGTGGTTCTAGCGTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAG
AAGTTCAAGGAGAGTTTCCGCGCTAACACGCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAG
CGGAGGAGCAAGTCTCGAGGAGGAATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTC
TACACGGAGCAGTACCGCAGTCGCCGCCGCAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGT
TCCTGCATCCTGGCCATGGTGTGTGGCAGCCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCA
GATGGAAGCAGCTTCGTGGTGAGTGAAGGGAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATC
AATGCCACCTCCCCATGGGTGAGGGACCTCTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGC
AGCTGTCATGAAGGCTATGCCCCTGACCCTGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTAC
ACGACACTTGAGAGGGGCTATGATCTGGTGACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGGTCTACTTTCAGCTTGGGCCAAGGCCTC
TGGCTTCCTGTCAGCAAAAGCTTTGTGGTTCCGCCTGTGGAGCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACG
GAAGACCCTGCAGATGTCAGGGAAGAAGCGATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGT
GACTGCTCTCGGAACAATGGGGGCTGCACTCGCAACTTCAAGTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAG
GAGCTGAAACCCATGAAGGATGGCTCTGGCTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAG
CTGTGCCTGCAGCAGACGCTGCCCCTGCCCTACGATGCCACTTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTG
GCTCCTGATGGAAAATCCTGCTTAATGCTCTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTC
TTTGGAGAGATGCTACATGGTTACAACAACCGGACCCAGCATGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTC
ATCAAGGACTTTCCCCAGCTGGCCGATGGGCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTT
CCAGACCTCCAACTGCTCACTGGAGATATCAGGTATGATGAGGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTC
TACCGTGTGAAGCTCAGCACCATCACCCTCGCAGCAGGCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTG
CTGTCCTTCATCCAGCACTATGGCTCCCACTACATCGCAGAGGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAG
AAGGTCCAGCAGCAGCTGTGGCTCCAGTATCAGAAAGAGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACC
TACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGT
CCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTT
TATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAAGAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATC
GATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCC
CCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTG
CAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTACACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGC
ACATCTTGTGTAGCAGCTGGTCGAAGCCATGGAGAGGTCCCTGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGT
CTCTACAAGTTCACTCTGTATGCTGTGGATACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTA
GATGACAACAAGGCAGAAGAAATAGCTGACAAGATCTACAATCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAAC
ACACTGATGGAGGTCTCAGCCTCGATGCTGTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGA
AGTGAGGATGAGCTGGGGCCCAGGAAGGCCCACCTGATTCTACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGT
GCCTACATCCAGAGCCGCGTGGAAACAGTGCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATC
CTCAAGGACACCAAAATCACGTGTGAGGAGAAGATGGTGTCAATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTA
TTGCCCTCCGTGAGCACAGAGACTCTCCATGGGAGGGGGAGCAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAG
GATGGGCCTAGCAGATGAAGCTTGCCAGCAAGGCCAAAGCAAACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAA
TTATTCATTTTTCTCTATCTTTTATTTTTTCAAAGATATTATTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGG
CTGTCAATCCCGAGGCAGAAGTTTTCAGGTGGAGACCAAGCGGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGC
CATGGACCCCTGGAGGAGACCTATGGAGGGACAGTTTTGACCTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAG
CTCTGAGGATGGTTGCAGTGAGGAAGCATGGGTCTTTAAGGACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCC

>70274_70274_1_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000262539_ASTN2_chr9_119903757_ENST00000313400_length(amino acids)=1047AA_BP=47
MAGSKQSHQEAVKRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKR
KRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFI
ADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWP
YTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPV
RDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYK
LAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEP
LPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPS
KKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVP
LYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYI
LQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPL
VDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLR

--------------------------------------------------------------
>70274_70274_2_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000262539_ASTN2_chr9_119903757_ENST00000373996_length(transcript)=4115nt_BP=496nt
CTCAGACGGCGGCCAGGTCGCGCCGCGAGCGAGCTTCCGCGCCGCCCGCACGCGCGACCTACCTGGGCGCTCCGCGCCCCCGGATGCTGC
AGGTTATTCAGCGATAGTTATGACCTCCCGGTTACGTGCGTTGGGTGGAAGAATTAATAATATACGCACCTCGGAGTTACCCAAAGAGAA
AACTCGATCAGAAGTCATTTGCAGCATCCACTTTTTAGATGGCGTGGTACAGACCTTTAAAGTTACTAAACAAGACACTGGCCAGGTTCT
TCTGGATATGGTGCACAACCACCTGGGTGTGACTGAAAAGGAATATTTTGGTTTACAGCATGATGACGACTCCGTGGACTCTCCTAGATG
GCTGGAAGCAAGCAAAGCCATCAGGAAGCAGTTAAAAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACC
TGCCCTCTTAACTCAGCAGTGGTTCTAGCGTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAG
AAGTTCAAGGAGAGTTTCCGCGCTAACACGCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAG
CGGAGGAGCAAGTCTCGAGGAGGAATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTC
TACACGGAGCAGTACCGCAGTCGCCGCCGCAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGT
TCCTGCATCCTGGCCATGGTGTGTGGCAGCCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCA
GATGGAAGCAGCTTCGTGGTGAGTGAAGGGAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATC
AATGCCACCTCCCCATGGGTGAGGGACCTCTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGC
AGCTGTCATGAAGGCTATGCCCCTGACCCTGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTAC
ACGACACTTGAGAGGGGCTATGATCTGGTGACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTC
AGCAAAAGCTTTGTGGTTCCGCCTGTGGAGCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCA
GATGTCAGGGAAGAAGCGATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGG
AACAATGGGGGCTGCACTCGCAACTTCAAGTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCC
ATGAAGGATGGCTCTGGCTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAG
CAGACGCTGCCCCTGCCCTACGATGCCACTTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGA
AAATCCTGCTTAATGCTCTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATG
CTACATGGTTACAACAACCGGACCCAGCATGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTT
CCCCAGCTGGCCGATGGGCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAA
CTGCTCACTGGAGATATCAGGTATGATGAGGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAG
CTCAGCACCATCACCCTCGCAGCAGGCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATC
CAGCACTATGGCTCCCACTACATCGCAGAGGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAG
CAGCTGTGGCTCCAGTATCAGAAAGAGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGT
TTGCTGACAGCCCAGATGCTGTCAGATGACCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGT
CACCTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATC
CAAGACAATGGCACAAAGGAGGCCTTCAAGAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGC
AGGTGTGACCTCAGCGCCTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAG
CCCTCCAGTACTGTGGTCTCCTTGGAGTGGGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAA
GTGGATGAATACACAGACACTGACCTGTACACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTA
GCAGCTGGTCGAAGCCATGGAGAGGTCCCTGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTC
ACTCTGTATGCTGTGGATACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAG
GCAGAAGAAATAGCTGACAAGATCTACAATCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAG
GTCTCAGCCTCGATGCTGTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAG
CTGGGGCCCAGGAAGGCCCACCTGATTCTACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAG
AGCCGCGTGGAAACAGTGCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACC
AAAATCACGTGTGAGGAGAAGATGGTGTCAATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTG
AGCACAGAGACTCTCCATGGGAGGGGGAGCAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGC
AGATGAAGCTTGCCAGCAAGGCCAAAGCAAACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTT
CTCTATCTTTTATTTTTTCAAAGATATTATTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCG
AGGCAGAAGTTTTCAGGTGGAGACCAAGCGGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTG
GAGGAGACCTATGGAGGGACAGTTTTGACCTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGG
TTGCAGTGAGGAAGCATGGGTCTTTAAGGACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTAC

>70274_70274_2_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000262539_ASTN2_chr9_119903757_ENST00000373996_length(amino acids)=1043AA_BP=47
MAGSKQSHQEAVKRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKR
KRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFI
ADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWP
YTTLERGYDLVTGEQAPEKILSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCS
RNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPD
GKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDL
QLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQ
QQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTL
IQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHK
KVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDN
KAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYI

--------------------------------------------------------------
>70274_70274_3_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000374541_ASTN2_chr9_119903757_ENST00000313400_length(transcript)=4202nt_BP=571nt
GACGGCGGCCAGGTCGCGCCGCGAGCGAGCTTCCGCGCCGCCCGCACGCGCGACCTACCTGGGCGCTCCGCGCCCCCGGATGCTGCAGGT
TATTCAGCGATAGTTATGACCTCCCGGTTACGTGCGTTGGGTGGAAGAATTAATAATATACGCACCTCGGAGTTACCCAAAGAGAAAACT
CGATCAGAAGTCATTTGCAGCATCCACTTTTTAGATGGCGTGGTACAGACCTTTAAAGTTACTAAACAAGACACTGGCCAGGTTCTTCTG
GATATGGTGCACAACCACCTGGGTGTGACTGAAAAGGAATATTTTGGTTTACAGCATGATGACGACTCCGTGGACTCTCCTAGATGGCTG
GAAGCAAGCAAAGCCATCAGGAAGCAGTTAAAAGGAGGTTTCCCCTGTACCCTGCATTTTCGAGTAAGATTTTTTATACCTGATCCCAAC
ACACTGCAGCAAGAACAAACCAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACCTGCCCTCTTAACTCA
GCAGTGGTTCTAGCGTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGT
TTCCGCGCTAACACGCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCT
CGAGGAGGAATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTAC
CGCAGTCGCCGCCGCAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCC
ATGGTGTGTGGCAGCCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCAGATGGAAGCAGCTTC
GTGGTGAGTGAAGGGAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCA
TGGGTGAGGGACCTCTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGCAGCTGTCATGAAGGC
TATGCCCCTGACCCTGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTACACGACACTTGAGAGG
GGCTATGATCTGGTGACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGGTCTACTTTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTCAGC
AAAAGCTTTGTGGTTCCGCCTGTGGAGCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGAT
GTCAGGGAAGAAGCGATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGGAAC
AATGGGGGCTGCACTCGCAACTTCAAGTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCCATG
AAGGATGGCTCTGGCTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAGCAG
ACGCTGCCCCTGCCCTACGATGCCACTTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAA
TCCTGCTTAATGCTCTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATGCTA
CATGGTTACAACAACCGGACCCAGCATGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTTCCC
CAGCTGGCCGATGGGCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAACTG
CTCACTGGAGATATCAGGTATGATGAGGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTC
AGCACCATCACCCTCGCAGCAGGCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATCCAG
CACTATGGCTCCCACTACATCGCAGAGGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAG
CTGTGGCTCCAGTATCAGAAAGAGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTG
CTGACAGCCCAGATGCTGTCAGATGACCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCAC
CTTTGCCGCCGGCCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAA
GACAATGGCACAAAGGAGGCCTTCAAGAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGG
TGTGACCTCAGCGCCTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCC
TCCAGTACTGTGGTCTCCTTGGAGTGGGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTG
GATGAATACACAGACACTGACCTGTACACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTAGCA
GCTGGTCGAAGCCATGGAGAGGTCCCTGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTCACT
CTGTATGCTGTGGATACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAGGCA
GAAGAAATAGCTGACAAGATCTACAATCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTC
TCAGCCTCGATGCTGTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAGCTG
GGGCCCAGGAAGGCCCACCTGATTCTACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGC
CGCGTGGAAACAGTGCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACCAAA
ATCACGTGTGAGGAGAAGATGGTGTCAATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTGAGC
ACAGAGACTCTCCATGGGAGGGGGAGCAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGCAGA
TGAAGCTTGCCAGCAAGGCCAAAGCAAACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTTCTC
TATCTTTTATTTTTTCAAAGATATTATTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCGAGG
CAGAAGTTTTCAGGTGGAGACCAAGCGGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTGGAG
GAGACCTATGGAGGGACAGTTTTGACCTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGGTTG
CAGTGAGGAAGCATGGGTCTTTAAGGACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTACCTG

>70274_70274_3_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000374541_ASTN2_chr9_119903757_ENST00000313400_length(amino acids)=1156AA_BP=156
MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA
IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANT
PIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGS
QMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDP
VHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEA
MLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLP
YDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADG
LLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSH
YIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRP
GKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVV
SLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVD
TRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKA

--------------------------------------------------------------
>70274_70274_4_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000374541_ASTN2_chr9_119903757_ENST00000373996_length(transcript)=4190nt_BP=571nt
GACGGCGGCCAGGTCGCGCCGCGAGCGAGCTTCCGCGCCGCCCGCACGCGCGACCTACCTGGGCGCTCCGCGCCCCCGGATGCTGCAGGT
TATTCAGCGATAGTTATGACCTCCCGGTTACGTGCGTTGGGTGGAAGAATTAATAATATACGCACCTCGGAGTTACCCAAAGAGAAAACT
CGATCAGAAGTCATTTGCAGCATCCACTTTTTAGATGGCGTGGTACAGACCTTTAAAGTTACTAAACAAGACACTGGCCAGGTTCTTCTG
GATATGGTGCACAACCACCTGGGTGTGACTGAAAAGGAATATTTTGGTTTACAGCATGATGACGACTCCGTGGACTCTCCTAGATGGCTG
GAAGCAAGCAAAGCCATCAGGAAGCAGTTAAAAGGAGGTTTCCCCTGTACCCTGCATTTTCGAGTAAGATTTTTTATACCTGATCCCAAC
ACACTGCAGCAAGAACAAACCAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACCTGCCCTCTTAACTCA
GCAGTGGTTCTAGCGTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGT
TTCCGCGCTAACACGCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCT
CGAGGAGGAATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTAC
CGCAGTCGCCGCCGCAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCC
ATGGTGTGTGGCAGCCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCAGATGGAAGCAGCTTC
GTGGTGAGTGAAGGGAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCA
TGGGTGAGGGACCTCTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGCAGCTGTCATGAAGGC
TATGCCCCTGACCCTGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTACACGACACTTGAGAGG
GGCTATGATCTGGTGACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTCAGCAAAAGCTTTGTG
GTTCCGCCTGTGGAGCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGATGTCAGGGAAGAA
GCGATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGGAACAATGGGGGCTGC
ACTCGCAACTTCAAGTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCCATGAAGGATGGCTCT
GGCTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAGCAGACGCTGCCCCTG
CCCTACGATGCCACTTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAATCCTGCTTAATG
CTCTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATGCTACATGGTTACAAC
AACCGGACCCAGCATGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTTCCCCAGCTGGCCGAT
GGGCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAACTGCTCACTGGAGAT
ATCAGGTATGATGAGGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTCAGCACCATCACC
CTCGCAGCAGGCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATCCAGCACTATGGCTCC
CACTACATCGCAGAGGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAGCTGTGGCTCCAG
TATCAGAAAGAGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAG
ATGCTGTCAGATGACCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGG
CCAGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACA
AAGGAGGCCTTCAAGAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGC
GCCTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTG
GTCTCCTTGGAGTGGGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACA
GACACTGACCTGTACACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTAGCAGCTGGTCGAAGC
CATGGAGAGGTCCCTGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTCACTCTGTATGCTGTG
GATACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAGGCAGAAGAAATAGCT
GACAAGATCTACAATCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTCTCAGCCTCGATG
CTGTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAGCTGGGGCCCAGGAAG
GCCCACCTGATTCTACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGCCGCGTGGAAACA
GTGCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACCAAAATCACGTGTGAG
GAGAAGATGGTGTCAATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTGAGCACAGAGACTCTC
CATGGGAGGGGGAGCAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGCAGATGAAGCTTGCCA
GCAAGGCCAAAGCAAACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTTCTCTATCTTTTATTT
TTTCAAAGATATTATTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCGAGGCAGAAGTTTTCA
GGTGGAGACCAAGCGGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTGGAGGAGACCTATGGA
GGGACAGTTTTGACCTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGGTTGCAGTGAGGAAGC
ATGGGTCTTTAAGGACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTACCTGTGGGTCTGCCCA

>70274_70274_4_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000374541_ASTN2_chr9_119903757_ENST00000373996_length(amino acids)=1152AA_BP=156
MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA
IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANT
PIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGS
QMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDP
VHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLST
YFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDAT
SSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVI
PLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAE
ALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQ
LSPTPVLLEINRVVPLYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEW
VDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGR
HSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLIL

--------------------------------------------------------------
>70274_70274_5_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000412145_ASTN2_chr9_119903757_ENST00000313400_length(transcript)=6258nt_BP=2627nt
GAAGGGTGGTATCCCGTTGTGGAGTAGAATGTAACTATGACCTTCTGGGATTTGGGCACCAGATTTATCTTACTGCAACAGGAGCCATGG
TGGGAGCCACCCCCATAACTCTTATAGAGCTGGTGGGCCACCAGGACTGCCAGATATATATATATATTTTTTGAAACAGGGTCTTGCTAT
GTTGCCCAGACTGGCCTCAAACTCCTGGACTCAAAGGATCCTCCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACATACCACCACGAC
TAGCTGCCAGATCATCTTATCTTGGACCAGGCTTCTACCATTAATTCACATGCTTTAAAAAAATTAAAAATTAAAAAAATGAAAAATAAA
AAAACTTAAAAGATTTTACCTATATTCCTGGAACATAGTTATCTTACCCCAGCTTTGTAGTTCCTGTTTAAGGAAATTCCCTCTGAAGGA
AATTTTAGCTCTCAAGAGTCAAAGAAGATGTATAGAGGTGGTATCTGTTAGTTTTTGTTTGTTTGTTAAGGATCTAGGCAGAGAGGTCAT
TACATTTTTCTGAAGTTGAGGTCACAGGTGGGGTACCCACAAGAGAGGTCATTACATTTCTGAAGTTAGGCATCCCAGGCATCTCTTCTA
AAGAACTATCCTGTATTCTAATTGTTAAATAAATATCTTCTTCATTGTGAGCCTCCACAACTGCTGTTTCTGATAAATTTAGATCATTCT
TTGCAGAATTTTATATACTGGCAATCTCAAAACTAGGCTCCTTCAAGATTCCTAGGAAGTCTCCCAAGCTCGGGTTGGGTTCCACTATTC
TAGTTTCTTTGTGTATGATGCCATGGGGTTGACTCAGAAACTTTGCTCAATATATGACAAGGCAGCATTTGGTGAGTGGTGATCTCCACG
TTTATCTTCTCATTTATATCCCTAGGAAGACATACTGATTAGCTGAGCTTGTCAATGAAAGCCCGGGTTCACCATTGGATTATCTATAAC
TCTCCTTTCTCTTTTTTTCTCTCAGTAGCATTGTAGGAGGAGAGAACACTTAATTCTGGTTGAATGTCAGCTTGGATAAACATAGAAACA
AACTAGAAAGAACTGATGATGTTCTCCTAGGTGGAAAAGATGGAGATTCCAATACCAAATAGGTGTGAATCAGCAAATGTATGTTATACT
GTCTCTCAAGGCCAGGTGTTCAATACATTGTGGGTAGTTAATTATAATCAAAGTAATAATATTAGAGTTACGACATGGATCCTAAGCTTT
TTAGCCATTAAACATATAAGAAATTTGTAGCATAGTGAGTTTTTTTATAACATGATCATCCAGGTTAAAATAAGACACAATTGACCTCAC
ATATCCTATCTGAGCTCCGATTTTGTCATCTGTAAAAATGGAGATAGTGGTACCTACCTTACAGAGTTATGAGGCTGAGATAAGAGGGAA
AGTTACAAAGTAGTACCATGTACAAAGCCCGGAACTGTGCAAATAGGAGGTTGTAATACTGTTTGAAGCATTCCCATCTCAAAAAGCCAG
TTCCTTGGCCTTTATAAATTTGAAGGAATAATGAAACTGATTTGTTTCAATTGTGAAAATTATTTCTCTCCTGCCCCTGTGCACTTCTGC
CCTGTCTATATTAGATTTCAAGAGGTTTCCCTTTTGTCATCTTGGCCAGACAATGGAATGTCTATCCCGTTTGAATCTGGGTTTAAAAAA
GCATGGGAGCTAGTGGCCAAGTGTCACATGTATGCCGCATCCCTAAATAGAAGTCTCCCCAGGGCGCTTCCTGACCTGCGCAATGCTGCC
GAAGGCCTCCTTTCCCCGCTCCCCAGGCAGAGGAGCAAAGTCACAGGCTGAGGGGCCTGCCACGACTTGCCCACAAAACAGGTCTGGAGT
TTGGAAGTTACATTTGCTGGTTGCCCAGAGATGAGTGCAGAATTCAGCTTGGAGGTCCTGGAAACTTCTAGTTTACTGATGTTTATGCTT
TTGCTCATGCACCCACAGTTCCTGGGACACAGAATGCTCACCTGGGGGTTTGTACCCCAGCCAAGAAGGTGTCTTCACAGACTCCCCTCC
TTTTAGCAACTTCATGCAGATGGAGCTTGGGTGGATGGATCCTGGCACAGTGTTCAGAACAGTGGCCCTGCCAGTGTGTGGGCGCCGCTT
GTGCAGAGCCCCTGTGGGTTCTGGTCCTCAAGGGCAGGGGCGCTCACTGACAGCGGAACCCATAGTACCAGCCCATCTTTGGTGGGCTGT
TTCCACCCCATTCATCCCTGCTCAGCTCTTCATAGGACAGCCTGTGCTGGCAGAAAATTGCCCCCACCAGTCAAGACGTAGGGCATCAAC
ATGAGCCATCAGTAATGACAGGGCAGCTTTGCAGAGCGTAAGGTAGCACCTGATACCTTGGACCAAAACCGTATTTTTATGTATCTTTCA
CATGTACAGCTCTTGTCTTTGACTCATCAAACTTTCTTTTTTTTTTTTTTTTGCTTATTTCAGTTTGAGTATGAATTAATGAAAACAATT
GTTTCATAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACCTGCCCTCTTAACTCAGCAGTGGTTCTAGC
GTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGTTTCCGCGCTAACAC
GCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCTCGAGGAGGAATCAG
CTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTACCGCAGTCGCCGCCG
CAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCCATGGTGTGTGGCAG
CCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCAGATGGAAGCAGCTTCGTGGTGAGTGAAGG
GAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCATGGGTGAGGGACCT
CTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGCAGCTGTCATGAAGGCTATGCCCCTGACCC
TGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTACACGACACTTGAGAGGGGCTATGATCTGGT
GACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGGTCTACTTTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTCAGCAAAAGCTTTGTGGT
TCCGCCTGTGGAGCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGATGTCAGGGAAGAAGC
GATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGGAACAATGGGGGCTGCAC
TCGCAACTTCAAGTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCCATGAAGGATGGCTCTGG
CTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAGCAGACGCTGCCCCTGCC
CTACGATGCCACTTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAATCCTGCTTAATGCT
CTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATGCTACATGGTTACAACAA
CCGGACCCAGCATGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTTCCCCAGCTGGCCGATGG
GCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAACTGCTCACTGGAGATAT
CAGGTATGATGAGGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTCAGCACCATCACCCT
CGCAGCAGGCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATCCAGCACTATGGCTCCCA
CTACATCGCAGAGGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAGCTGTGGCTCCAGTA
TCAGAAAGAGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGAT
GCTGTCAGATGACCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCC
AGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAA
GGAGGCCTTCAAGAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGC
CTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGT
CTCCTTGGAGTGGGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGA
CACTGACCTGTACACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTAGCAGCTGGTCGAAGCCA
TGGAGAGGTCCCTGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTCACTCTGTATGCTGTGGA
TACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAGGCAGAAGAAATAGCTGA
CAAGATCTACAATCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTCTCAGCCTCGATGCT
GTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAGCTGGGGCCCAGGAAGGC
CCACCTGATTCTACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGCCGCGTGGAAACAGT
GCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACCAAAATCACGTGTGAGGA
GAAGATGGTGTCAATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTGAGCACAGAGACTCTCCA
TGGGAGGGGGAGCAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGCAGATGAAGCTTGCCAGC
AAGGCCAAAGCAAACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTTCTCTATCTTTTATTTTT
TCAAAGATATTATTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCGAGGCAGAAGTTTTCAGG
TGGAGACCAAGCGGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTGGAGGAGACCTATGGAGG
GACAGTTTTGACCTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGGTTGCAGTGAGGAAGCAT
GGGTCTTTAAGGACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTACCTGTGGGTCTGCCCAGA

>70274_70274_5_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000412145_ASTN2_chr9_119903757_ENST00000313400_length(amino acids)=1037AA_BP=37
MFHRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGI
SFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSE
GSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDL
VTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGC
TRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLM
LSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGD
IRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQ
YQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGT
KEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYT
DTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIA
DKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVET

--------------------------------------------------------------
>70274_70274_6_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000412145_ASTN2_chr9_119903757_ENST00000373996_length(transcript)=6246nt_BP=2627nt
GAAGGGTGGTATCCCGTTGTGGAGTAGAATGTAACTATGACCTTCTGGGATTTGGGCACCAGATTTATCTTACTGCAACAGGAGCCATGG
TGGGAGCCACCCCCATAACTCTTATAGAGCTGGTGGGCCACCAGGACTGCCAGATATATATATATATTTTTTGAAACAGGGTCTTGCTAT
GTTGCCCAGACTGGCCTCAAACTCCTGGACTCAAAGGATCCTCCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACATACCACCACGAC
TAGCTGCCAGATCATCTTATCTTGGACCAGGCTTCTACCATTAATTCACATGCTTTAAAAAAATTAAAAATTAAAAAAATGAAAAATAAA
AAAACTTAAAAGATTTTACCTATATTCCTGGAACATAGTTATCTTACCCCAGCTTTGTAGTTCCTGTTTAAGGAAATTCCCTCTGAAGGA
AATTTTAGCTCTCAAGAGTCAAAGAAGATGTATAGAGGTGGTATCTGTTAGTTTTTGTTTGTTTGTTAAGGATCTAGGCAGAGAGGTCAT
TACATTTTTCTGAAGTTGAGGTCACAGGTGGGGTACCCACAAGAGAGGTCATTACATTTCTGAAGTTAGGCATCCCAGGCATCTCTTCTA
AAGAACTATCCTGTATTCTAATTGTTAAATAAATATCTTCTTCATTGTGAGCCTCCACAACTGCTGTTTCTGATAAATTTAGATCATTCT
TTGCAGAATTTTATATACTGGCAATCTCAAAACTAGGCTCCTTCAAGATTCCTAGGAAGTCTCCCAAGCTCGGGTTGGGTTCCACTATTC
TAGTTTCTTTGTGTATGATGCCATGGGGTTGACTCAGAAACTTTGCTCAATATATGACAAGGCAGCATTTGGTGAGTGGTGATCTCCACG
TTTATCTTCTCATTTATATCCCTAGGAAGACATACTGATTAGCTGAGCTTGTCAATGAAAGCCCGGGTTCACCATTGGATTATCTATAAC
TCTCCTTTCTCTTTTTTTCTCTCAGTAGCATTGTAGGAGGAGAGAACACTTAATTCTGGTTGAATGTCAGCTTGGATAAACATAGAAACA
AACTAGAAAGAACTGATGATGTTCTCCTAGGTGGAAAAGATGGAGATTCCAATACCAAATAGGTGTGAATCAGCAAATGTATGTTATACT
GTCTCTCAAGGCCAGGTGTTCAATACATTGTGGGTAGTTAATTATAATCAAAGTAATAATATTAGAGTTACGACATGGATCCTAAGCTTT
TTAGCCATTAAACATATAAGAAATTTGTAGCATAGTGAGTTTTTTTATAACATGATCATCCAGGTTAAAATAAGACACAATTGACCTCAC
ATATCCTATCTGAGCTCCGATTTTGTCATCTGTAAAAATGGAGATAGTGGTACCTACCTTACAGAGTTATGAGGCTGAGATAAGAGGGAA
AGTTACAAAGTAGTACCATGTACAAAGCCCGGAACTGTGCAAATAGGAGGTTGTAATACTGTTTGAAGCATTCCCATCTCAAAAAGCCAG
TTCCTTGGCCTTTATAAATTTGAAGGAATAATGAAACTGATTTGTTTCAATTGTGAAAATTATTTCTCTCCTGCCCCTGTGCACTTCTGC
CCTGTCTATATTAGATTTCAAGAGGTTTCCCTTTTGTCATCTTGGCCAGACAATGGAATGTCTATCCCGTTTGAATCTGGGTTTAAAAAA
GCATGGGAGCTAGTGGCCAAGTGTCACATGTATGCCGCATCCCTAAATAGAAGTCTCCCCAGGGCGCTTCCTGACCTGCGCAATGCTGCC
GAAGGCCTCCTTTCCCCGCTCCCCAGGCAGAGGAGCAAAGTCACAGGCTGAGGGGCCTGCCACGACTTGCCCACAAAACAGGTCTGGAGT
TTGGAAGTTACATTTGCTGGTTGCCCAGAGATGAGTGCAGAATTCAGCTTGGAGGTCCTGGAAACTTCTAGTTTACTGATGTTTATGCTT
TTGCTCATGCACCCACAGTTCCTGGGACACAGAATGCTCACCTGGGGGTTTGTACCCCAGCCAAGAAGGTGTCTTCACAGACTCCCCTCC
TTTTAGCAACTTCATGCAGATGGAGCTTGGGTGGATGGATCCTGGCACAGTGTTCAGAACAGTGGCCCTGCCAGTGTGTGGGCGCCGCTT
GTGCAGAGCCCCTGTGGGTTCTGGTCCTCAAGGGCAGGGGCGCTCACTGACAGCGGAACCCATAGTACCAGCCCATCTTTGGTGGGCTGT
TTCCACCCCATTCATCCCTGCTCAGCTCTTCATAGGACAGCCTGTGCTGGCAGAAAATTGCCCCCACCAGTCAAGACGTAGGGCATCAAC
ATGAGCCATCAGTAATGACAGGGCAGCTTTGCAGAGCGTAAGGTAGCACCTGATACCTTGGACCAAAACCGTATTTTTATGTATCTTTCA
CATGTACAGCTCTTGTCTTTGACTCATCAAACTTTCTTTTTTTTTTTTTTTTGCTTATTTCAGTTTGAGTATGAATTAATGAAAACAATT
GTTTCATAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACCTGCCCTCTTAACTCAGCAGTGGTTCTAGC
GTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGTTTCCGCGCTAACAC
GCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCTCGAGGAGGAATCAG
CTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTACCGCAGTCGCCGCCG
CAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCCATGGTGTGTGGCAG
CCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCAGATGGAAGCAGCTTCGTGGTGAGTGAAGG
GAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCATGGGTGAGGGACCT
CTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGCAGCTGTCATGAAGGCTATGCCCCTGACCC
TGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTACACGACACTTGAGAGGGGCTATGATCTGGT
GACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTCAGCAAAAGCTTTGTGGTTCCGCCTGTGGA
GCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGATGTCAGGGAAGAAGCGATGCTGTCCAC
ATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGGAACAATGGGGGCTGCACTCGCAACTTCAA
GTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCCATGAAGGATGGCTCTGGCTGCTACGACCA
CTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAGCAGACGCTGCCCCTGCCCTACGATGCCAC
TTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAATCCTGCTTAATGCTCTCAGATGTCTG
CGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATGCTACATGGTTACAACAACCGGACCCAGCA
TGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTTCCCCAGCTGGCCGATGGGCTGTTGGTGAT
CCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAACTGCTCACTGGAGATATCAGGTATGATGA
GGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTCAGCACCATCACCCTCGCAGCAGGCTT
CACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATCCAGCACTATGGCTCCCACTACATCGCAGA
GGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAGCTGTGGCTCCAGTATCAGAAAGAGAC
CACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGA
CCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCA
GCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAA
GAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAA
TGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTG
GGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTA
CACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTAGCAGCTGGTCGAAGCCATGGAGAGGTCCC
TGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTCACTCTGTATGCTGTGGATACACGAGGGAG
GCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAGGCAGAAGAAATAGCTGACAAGATCTACAA
TCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTCTCAGCCTCGATGCTGTTCCGAGTCCA
GCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAGCTGGGGCCCAGGAAGGCCCACCTGATTCT
ACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGCCGCGTGGAAACAGTGCCCTATCTTTT
CTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACCAAAATCACGTGTGAGGAGAAGATGGTGTC
AATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTGAGCACAGAGACTCTCCATGGGAGGGGGAG
CAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGCAGATGAAGCTTGCCAGCAAGGCCAAAGCA
AACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTTCTCTATCTTTTATTTTTTCAAAGATATTA
TTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCGAGGCAGAAGTTTTCAGGTGGAGACCAAGC
GGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTGGAGGAGACCTATGGAGGGACAGTTTTGAC
CTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGGTTGCAGTGAGGAAGCATGGGTCTTTAAGG
ACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTACCTGTGGGTCTGCCCAGAGTCCCTGCAGGC

>70274_70274_6_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000412145_ASTN2_chr9_119903757_ENST00000373996_length(amino acids)=1033AA_BP=37
MFHRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGI
SFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSE
GSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDL
VTGEQAPEKILSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNF
KCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDV
CEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYD
EAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKE
TTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAF
KSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDL
YTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIY
NLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVETVPYL

--------------------------------------------------------------
>70274_70274_7_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000446349_ASTN2_chr9_119903757_ENST00000313400_length(transcript)=6258nt_BP=2627nt
GAAGGGTGGTATCCCGTTGTGGAGTAGAATGTAACTATGACCTTCTGGGATTTGGGCACCAGATTTATCTTACTGCAACAGGAGCCATGG
TGGGAGCCACCCCCATAACTCTTATAGAGCTGGTGGGCCACCAGGACTGCCAGATATATATATATATTTTTTGAAACAGGGTCTTGCTAT
GTTGCCCAGACTGGCCTCAAACTCCTGGACTCAAAGGATCCTCCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACATACCACCACGAC
TAGCTGCCAGATCATCTTATCTTGGACCAGGCTTCTACCATTAATTCACATGCTTTAAAAAAATTAAAAATTAAAAAAATGAAAAATAAA
AAAACTTAAAAGATTTTACCTATATTCCTGGAACATAGTTATCTTACCCCAGCTTTGTAGTTCCTGTTTAAGGAAATTCCCTCTGAAGGA
AATTTTAGCTCTCAAGAGTCAAAGAAGATGTATAGAGGTGGTATCTGTTAGTTTTTGTTTGTTTGTTAAGGATCTAGGCAGAGAGGTCAT
TACATTTTTCTGAAGTTGAGGTCACAGGTGGGGTACCCACAAGAGAGGTCATTACATTTCTGAAGTTAGGCATCCCAGGCATCTCTTCTA
AAGAACTATCCTGTATTCTAATTGTTAAATAAATATCTTCTTCATTGTGAGCCTCCACAACTGCTGTTTCTGATAAATTTAGATCATTCT
TTGCAGAATTTTATATACTGGCAATCTCAAAACTAGGCTCCTTCAAGATTCCTAGGAAGTCTCCCAAGCTCGGGTTGGGTTCCACTATTC
TAGTTTCTTTGTGTATGATGCCATGGGGTTGACTCAGAAACTTTGCTCAATATATGACAAGGCAGCATTTGGTGAGTGGTGATCTCCACG
TTTATCTTCTCATTTATATCCCTAGGAAGACATACTGATTAGCTGAGCTTGTCAATGAAAGCCCGGGTTCACCATTGGATTATCTATAAC
TCTCCTTTCTCTTTTTTTCTCTCAGTAGCATTGTAGGAGGAGAGAACACTTAATTCTGGTTGAATGTCAGCTTGGATAAACATAGAAACA
AACTAGAAAGAACTGATGATGTTCTCCTAGGTGGAAAAGATGGAGATTCCAATACCAAATAGGTGTGAATCAGCAAATGTATGTTATACT
GTCTCTCAAGGCCAGGTGTTCAATACATTGTGGGTAGTTAATTATAATCAAAGTAATAATATTAGAGTTACGACATGGATCCTAAGCTTT
TTAGCCATTAAACATATAAGAAATTTGTAGCATAGTGAGTTTTTTTATAACATGATCATCCAGGTTAAAATAAGACACAATTGACCTCAC
ATATCCTATCTGAGCTCCGATTTTGTCATCTGTAAAAATGGAGATAGTGGTACCTACCTTACAGAGTTATGAGGCTGAGATAAGAGGGAA
AGTTACAAAGTAGTACCATGTACAAAGCCCGGAACTGTGCAAATAGGAGGTTGTAATACTGTTTGAAGCATTCCCATCTCAAAAAGCCAG
TTCCTTGGCCTTTATAAATTTGAAGGAATAATGAAACTGATTTGTTTCAATTGTGAAAATTATTTCTCTCCTGCCCCTGTGCACTTCTGC
CCTGTCTATATTAGATTTCAAGAGGTTTCCCTTTTGTCATCTTGGCCAGACAATGGAATGTCTATCCCGTTTGAATCTGGGTTTAAAAAA
GCATGGGAGCTAGTGGCCAAGTGTCACATGTATGCCGCATCCCTAAATAGAAGTCTCCCCAGGGCGCTTCCTGACCTGCGCAATGCTGCC
GAAGGCCTCCTTTCCCCGCTCCCCAGGCAGAGGAGCAAAGTCACAGGCTGAGGGGCCTGCCACGACTTGCCCACAAAACAGGTCTGGAGT
TTGGAAGTTACATTTGCTGGTTGCCCAGAGATGAGTGCAGAATTCAGCTTGGAGGTCCTGGAAACTTCTAGTTTACTGATGTTTATGCTT
TTGCTCATGCACCCACAGTTCCTGGGACACAGAATGCTCACCTGGGGGTTTGTACCCCAGCCAAGAAGGTGTCTTCACAGACTCCCCTCC
TTTTAGCAACTTCATGCAGATGGAGCTTGGGTGGATGGATCCTGGCACAGTGTTCAGAACAGTGGCCCTGCCAGTGTGTGGGCGCCGCTT
GTGCAGAGCCCCTGTGGGTTCTGGTCCTCAAGGGCAGGGGCGCTCACTGACAGCGGAACCCATAGTACCAGCCCATCTTTGGTGGGCTGT
TTCCACCCCATTCATCCCTGCTCAGCTCTTCATAGGACAGCCTGTGCTGGCAGAAAATTGCCCCCACCAGTCAAGACGTAGGGCATCAAC
ATGAGCCATCAGTAATGACAGGGCAGCTTTGCAGAGCGTAAGGTAGCACCTGATACCTTGGACCAAAACCGTATTTTTATGTATCTTTCA
CATGTACAGCTCTTGTCTTTGACTCATCAAACTTTCTTTTTTTTTTTTTTTTGCTTATTTCAGTTTGAGTATGAATTAATGAAAACAATT
GTTTCATAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACCTGCCCTCTTAACTCAGCAGTGGTTCTAGC
GTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGTTTCCGCGCTAACAC
GCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCTCGAGGAGGAATCAG
CTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTACCGCAGTCGCCGCCG
CAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCCATGGTGTGTGGCAG
CCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCAGATGGAAGCAGCTTCGTGGTGAGTGAAGG
GAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCATGGGTGAGGGACCT
CTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGCAGCTGTCATGAAGGCTATGCCCCTGACCC
TGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTACACGACACTTGAGAGGGGCTATGATCTGGT
GACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGGTCTACTTTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTCAGCAAAAGCTTTGTGGT
TCCGCCTGTGGAGCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGATGTCAGGGAAGAAGC
GATGCTGTCCACATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGGAACAATGGGGGCTGCAC
TCGCAACTTCAAGTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCCATGAAGGATGGCTCTGG
CTGCTACGACCACTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAGCAGACGCTGCCCCTGCC
CTACGATGCCACTTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAATCCTGCTTAATGCT
CTCAGATGTCTGCGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATGCTACATGGTTACAACAA
CCGGACCCAGCATGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTTCCCCAGCTGGCCGATGG
GCTGTTGGTGATCCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAACTGCTCACTGGAGATAT
CAGGTATGATGAGGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTCAGCACCATCACCCT
CGCAGCAGGCTTCACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATCCAGCACTATGGCTCCCA
CTACATCGCAGAGGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAGCTGTGGCTCCAGTA
TCAGAAAGAGACCACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGAT
GCTGTCAGATGACCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCC
AGGCAAGGAGCAGCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAA
GGAGGCCTTCAAGAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGC
CTTTGATGCCAATGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGT
CTCCTTGGAGTGGGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGA
CACTGACCTGTACACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTAGCAGCTGGTCGAAGCCA
TGGAGAGGTCCCTGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTCACTCTGTATGCTGTGGA
TACACGAGGGAGGCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAGGCAGAAGAAATAGCTGA
CAAGATCTACAATCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTCTCAGCCTCGATGCT
GTTCCGAGTCCAGCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAGCTGGGGCCCAGGAAGGC
CCACCTGATTCTACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGCCGCGTGGAAACAGT
GCCCTATCTTTTCTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACCAAAATCACGTGTGAGGA
GAAGATGGTGTCAATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTGAGCACAGAGACTCTCCA
TGGGAGGGGGAGCAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGCAGATGAAGCTTGCCAGC
AAGGCCAAAGCAAACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTTCTCTATCTTTTATTTTT
TCAAAGATATTATTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCGAGGCAGAAGTTTTCAGG
TGGAGACCAAGCGGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTGGAGGAGACCTATGGAGG
GACAGTTTTGACCTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGGTTGCAGTGAGGAAGCAT
GGGTCTTTAAGGACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTACCTGTGGGTCTGCCCAGA

>70274_70274_7_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000446349_ASTN2_chr9_119903757_ENST00000313400_length(amino acids)=1037AA_BP=37
MFHRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGI
SFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSE
GSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDL
VTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGC
TRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLM
LSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGD
IRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQ
YQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGT
KEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYT
DTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIA
DKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVET

--------------------------------------------------------------
>70274_70274_8_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000446349_ASTN2_chr9_119903757_ENST00000373996_length(transcript)=6246nt_BP=2627nt
GAAGGGTGGTATCCCGTTGTGGAGTAGAATGTAACTATGACCTTCTGGGATTTGGGCACCAGATTTATCTTACTGCAACAGGAGCCATGG
TGGGAGCCACCCCCATAACTCTTATAGAGCTGGTGGGCCACCAGGACTGCCAGATATATATATATATTTTTTGAAACAGGGTCTTGCTAT
GTTGCCCAGACTGGCCTCAAACTCCTGGACTCAAAGGATCCTCCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACATACCACCACGAC
TAGCTGCCAGATCATCTTATCTTGGACCAGGCTTCTACCATTAATTCACATGCTTTAAAAAAATTAAAAATTAAAAAAATGAAAAATAAA
AAAACTTAAAAGATTTTACCTATATTCCTGGAACATAGTTATCTTACCCCAGCTTTGTAGTTCCTGTTTAAGGAAATTCCCTCTGAAGGA
AATTTTAGCTCTCAAGAGTCAAAGAAGATGTATAGAGGTGGTATCTGTTAGTTTTTGTTTGTTTGTTAAGGATCTAGGCAGAGAGGTCAT
TACATTTTTCTGAAGTTGAGGTCACAGGTGGGGTACCCACAAGAGAGGTCATTACATTTCTGAAGTTAGGCATCCCAGGCATCTCTTCTA
AAGAACTATCCTGTATTCTAATTGTTAAATAAATATCTTCTTCATTGTGAGCCTCCACAACTGCTGTTTCTGATAAATTTAGATCATTCT
TTGCAGAATTTTATATACTGGCAATCTCAAAACTAGGCTCCTTCAAGATTCCTAGGAAGTCTCCCAAGCTCGGGTTGGGTTCCACTATTC
TAGTTTCTTTGTGTATGATGCCATGGGGTTGACTCAGAAACTTTGCTCAATATATGACAAGGCAGCATTTGGTGAGTGGTGATCTCCACG
TTTATCTTCTCATTTATATCCCTAGGAAGACATACTGATTAGCTGAGCTTGTCAATGAAAGCCCGGGTTCACCATTGGATTATCTATAAC
TCTCCTTTCTCTTTTTTTCTCTCAGTAGCATTGTAGGAGGAGAGAACACTTAATTCTGGTTGAATGTCAGCTTGGATAAACATAGAAACA
AACTAGAAAGAACTGATGATGTTCTCCTAGGTGGAAAAGATGGAGATTCCAATACCAAATAGGTGTGAATCAGCAAATGTATGTTATACT
GTCTCTCAAGGCCAGGTGTTCAATACATTGTGGGTAGTTAATTATAATCAAAGTAATAATATTAGAGTTACGACATGGATCCTAAGCTTT
TTAGCCATTAAACATATAAGAAATTTGTAGCATAGTGAGTTTTTTTATAACATGATCATCCAGGTTAAAATAAGACACAATTGACCTCAC
ATATCCTATCTGAGCTCCGATTTTGTCATCTGTAAAAATGGAGATAGTGGTACCTACCTTACAGAGTTATGAGGCTGAGATAAGAGGGAA
AGTTACAAAGTAGTACCATGTACAAAGCCCGGAACTGTGCAAATAGGAGGTTGTAATACTGTTTGAAGCATTCCCATCTCAAAAAGCCAG
TTCCTTGGCCTTTATAAATTTGAAGGAATAATGAAACTGATTTGTTTCAATTGTGAAAATTATTTCTCTCCTGCCCCTGTGCACTTCTGC
CCTGTCTATATTAGATTTCAAGAGGTTTCCCTTTTGTCATCTTGGCCAGACAATGGAATGTCTATCCCGTTTGAATCTGGGTTTAAAAAA
GCATGGGAGCTAGTGGCCAAGTGTCACATGTATGCCGCATCCCTAAATAGAAGTCTCCCCAGGGCGCTTCCTGACCTGCGCAATGCTGCC
GAAGGCCTCCTTTCCCCGCTCCCCAGGCAGAGGAGCAAAGTCACAGGCTGAGGGGCCTGCCACGACTTGCCCACAAAACAGGTCTGGAGT
TTGGAAGTTACATTTGCTGGTTGCCCAGAGATGAGTGCAGAATTCAGCTTGGAGGTCCTGGAAACTTCTAGTTTACTGATGTTTATGCTT
TTGCTCATGCACCCACAGTTCCTGGGACACAGAATGCTCACCTGGGGGTTTGTACCCCAGCCAAGAAGGTGTCTTCACAGACTCCCCTCC
TTTTAGCAACTTCATGCAGATGGAGCTTGGGTGGATGGATCCTGGCACAGTGTTCAGAACAGTGGCCCTGCCAGTGTGTGGGCGCCGCTT
GTGCAGAGCCCCTGTGGGTTCTGGTCCTCAAGGGCAGGGGCGCTCACTGACAGCGGAACCCATAGTACCAGCCCATCTTTGGTGGGCTGT
TTCCACCCCATTCATCCCTGCTCAGCTCTTCATAGGACAGCCTGTGCTGGCAGAAAATTGCCCCCACCAGTCAAGACGTAGGGCATCAAC
ATGAGCCATCAGTAATGACAGGGCAGCTTTGCAGAGCGTAAGGTAGCACCTGATACCTTGGACCAAAACCGTATTTTTATGTATCTTTCA
CATGTACAGCTCTTGTCTTTGACTCATCAAACTTTCTTTTTTTTTTTTTTTTGCTTATTTCAGTTTGAGTATGAATTAATGAAAACAATT
GTTTCATAGGCACTTGTATTTCTTACAACTGAAGATGGATATTTGCGAAGGAAGGTTAACCTGCCCTCTTAACTCAGCAGTGGTTCTAGC
GTCCTATGCCGTACAATCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGTTTCCGCGCTAACAC
GCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCTCGAGGAGGAATCAG
CTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTACCGCAGTCGCCGCCG
CAGCAAAGGTTTGCTGAAAAGCCCAGTGAACAAGACAGCCCTGACACTGATTGCTGTGAGTTCCTGCATCCTGGCCATGGTGTGTGGCAG
CCAGATGTCTTGTCCACTCACTGTGAAGGTGACTCTGCATGTGCCCGAGCACTTCATAGCAGATGGAAGCAGCTTCGTGGTGAGTGAAGG
GAGCTACCTGGACATCTCCGACTGGTTAAACCCGGCCAAGCTTTCCCTGTATTACCAGATCAATGCCACCTCCCCATGGGTGAGGGACCT
CTGTGGACAAAGGACGACAGATGCCTGTGAGCAGCTCTGCGACCCAGAAACCGGAGAGTGCAGCTGTCATGAAGGCTATGCCCCTGACCC
TGTTCACAGACACCTGTGTGTGCGCAGTGACTGGGGACAGAGTGAAGGACCTTGGCCCTACACGACACTTGAGAGGGGCTATGATCTGGT
GACAGGGGAGCAAGCCCCTGAAAAGATTCTCAGCTTGGGCCAAGGCCTCTGGCTTCCTGTCAGCAAAAGCTTTGTGGTTCCGCCTGTGGA
GCTGTCCATCAACCCCCTGGCCAGCTGCAAGACCGATGTGCTCGTCACGGAAGACCCTGCAGATGTCAGGGAAGAAGCGATGCTGTCCAC
ATACTTTGAAACCATCAATGACCTGCTGTCTTCCTTCGGGCCAGTTCGTGACTGCTCTCGGAACAATGGGGGCTGCACTCGCAACTTCAA
GTGTGTGTCTGACCGGCAGGTGGATTCCTCGGGATGTGTGTGCCCTGAGGAGCTGAAACCCATGAAGGATGGCTCTGGCTGCTACGACCA
CTCCAAAGGCATTGACTGCTCTGATGGCTTTAATGGCGGCTGTGAGCAGCTGTGCCTGCAGCAGACGCTGCCCCTGCCCTACGATGCCAC
TTCGAGCACCATCTTCATGTTCTGCGGTTGCGTGGAGGAGTACAAACTGGCTCCTGATGGAAAATCCTGCTTAATGCTCTCAGATGTCTG
CGAGGGCCCCAAGTGCCTCAAACCTGACTCCAAATTCAATGATACCCTCTTTGGAGAGATGCTACATGGTTACAACAACCGGACCCAGCA
TGTGAACCAAGGCCAAGTCTTCCAGATGACCTTTAGGGAGAACAACTTCATCAAGGACTTTCCCCAGCTGGCCGATGGGCTGTTGGTGAT
CCCGCTGCCGGTGGAGGAGCAGTGCCGGGGGGTCCTCTCCGAGCCCCTTCCAGACCTCCAACTGCTCACTGGAGATATCAGGTATGATGA
GGCCATGGGTTACCCCATGGTGCAGCAGTGGCGGGTCCGGAGCAACCTCTACCGTGTGAAGCTCAGCACCATCACCCTCGCAGCAGGCTT
CACTAATGTTCTCAAGATCCTGACCAAGGAGAGCAGTCGGGAGGAGCTGCTGTCCTTCATCCAGCACTATGGCTCCCACTACATCGCAGA
GGCCCTCTATGGCTCAGAGCTCACCTGCATCATCCACTTTCCCAGCAAGAAGGTCCAGCAGCAGCTGTGGCTCCAGTATCAGAAAGAGAC
CACAGAGCTGGGCAGCAAGAAGGAGCTCAAGTCCATGCCCTTCATCACCTACCTCTCAGGTTTGCTGACAGCCCAGATGCTGTCAGATGA
CCAGCTCATTTCAGGTGTGGAGATTCGCTGTGAGGAGAAGGGGCGCTGTCCATCTACCTGTCACCTTTGCCGCCGGCCAGGCAAGGAGCA
GCTGAGCCCCACACCAGTGCTGCTGGAAATCAACCGTGTGGTGCCACTTTATACCCTCATCCAAGACAATGGCACAAAGGAGGCCTTCAA
GAGTGCACTGATGAGTTCCTACTGGTGCTCAGGGAAAGGGGATGTGATCGATGACTGGTGCAGGTGTGACCTCAGCGCCTTTGATGCCAA
TGGGCTCCCCAACTGCAGCCCCCTTCTGCAGCCGGTGCTGCGGCTGTCCCCAACAGTGGAGCCCTCCAGTACTGTGGTCTCCTTGGAGTG
GGTGGATGTTCAGCCAGCTATTGGGACCAAGGTCTCCGACTATATTCTGCAGCATAAGAAAGTGGATGAATACACAGACACTGACCTGTA
CACAGGAGAATTCCTGAGTTTTGCTGATGACTTACTCTCTGGCCTGGGCACATCTTGTGTAGCAGCTGGTCGAAGCCATGGAGAGGTCCC
TGAAGTCAGTATCTACTCAGTCATCTTCAAGTGTCTGGAGCCCGACGGTCTCTACAAGTTCACTCTGTATGCTGTGGATACACGAGGGAG
GCACTCAGAGCTAAGCACGGTGACCCTGAGGACGGCCTGTCCACTGGTAGATGACAACAAGGCAGAAGAAATAGCTGACAAGATCTACAA
TCTGTACAATGGGTACACAAGTGGAAAGGAGCAGCAGATGGCCTACAACACACTGATGGAGGTCTCAGCCTCGATGCTGTTCCGAGTCCA
GCACCACTACAACTCTCACTATGAAAAGTTTGGCGACTTCGTCTGGAGAAGTGAGGATGAGCTGGGGCCCAGGAAGGCCCACCTGATTCT
ACGGCGACTGGAGAGGGTGAGTAGCCACTGCTCCAGCCTCCTGCGGAGTGCCTACATCCAGAGCCGCGTGGAAACAGTGCCCTATCTTTT
CTGCCGCAGCGAGGAGGTCCGGCCTGCAGGCATGGTGTGGTATAGCATCCTCAAGGACACCAAAATCACGTGTGAGGAGAAGATGGTGTC
AATGGCCCGAAACACGTACGGGGAGTCCAAGGGCCGGTGAGGGAGGGTATTGCCCTCCGTGAGCACAGAGACTCTCCATGGGAGGGGGAG
CAGTATTCTCCTGGATCCTGGGGCCTGGGTGGGCTGGGGGACAGCTGAGGATGGGCCTAGCAGATGAAGCTTGCCAGCAAGGCCAAAGCA
AACGGTTTCTCCTGTGGATAGTGGACAGAGACCTTTGTAACCAATGGAATTATTCATTTTTCTCTATCTTTTATTTTTTCAAAGATATTA
TTTGACTCTATCAAAAGTCTCTCCTTTTTAAACCTTTTCTTATGGATGGCTGTCAATCCCGAGGCAGAAGTTTTCAGGTGGAGACCAAGC
GGCCTTTGCTCTTCTTCCTTCTTCCTGCCACACTCTGCTTTCTTCCTGCCATGGACCCCTGGAGGAGACCTATGGAGGGACAGTTTTGAC
CTGACCCCTAGAGGAGACAGTTTTGACCTCTTCAGCACCAGGAAGGAAGCTCTGAGGATGGTTGCAGTGAGGAAGCATGGGTCTTTAAGG
ACTTCTCTCTCTTTTTTGCTGGACATTATTGAGTTTGTGGGACCCTGCCTCTTCCTGCTACCTGTGGGTCTGCCCAGAGTCCCTGCAGGC

>70274_70274_8_PTPN3-ASTN2_PTPN3_chr9_112207520_ENST00000446349_ASTN2_chr9_119903757_ENST00000373996_length(amino acids)=1033AA_BP=37
MFHRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGI
SFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSE
GSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDL
VTGEQAPEKILSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNF
KCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDV
CEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYD
EAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKE
TTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAF
KSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDL
YTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIY
NLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVETVPYL

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Fusion Gene PPI Analysis for PTPN3-ASTN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPN3-ASTN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPN3-ASTN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource