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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPN6-LEPREL2 (FusionGDB2 ID:70290)

Fusion Gene Summary for PTPN6-LEPREL2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN6-LEPREL2
Fusion gene ID: 70290
HgeneTgene
Gene symbol

PTPN6

LEPREL2

Gene ID

5777

10536

Gene nameprotein tyrosine phosphatase non-receptor type 6prolyl 3-hydroxylase 3
SynonymsHCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1GRCB|HSU47926|LEPREL2
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 6hematopoietic cell phosphatasehematopoietic cell protein-tyrosine phosphataseprotein-tyrosine phosphatase 1Cprotein-tyrosine phosphatase SHP-1prolyl 3-hydroxylase 3gene rich cluster, Bleprecan-like 2procollagen-proline 3-dioxygenaseprotein B
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000318974, ENST00000399448, 
ENST00000447931, ENST00000456013, 
ENST00000539029, 		ENST00000538102, 
ENST00000251761, ENST00000396725, 
ENST00000606935, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 2=8
# samples 62
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PTPN6 [Title/Abstract] AND LEPREL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPN6(7066948)-LEPREL2(6948164), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN6

GO:0006470

protein dephosphorylation

11266449

HgenePTPN6

GO:0018108

peptidyl-tyrosine phosphorylation

9285411|18802077

HgenePTPN6

GO:0030154

cell differentiation

11266449

HgenePTPN6

GO:0070372

regulation of ERK1 and ERK2 cascade

11266449

TgeneLEPREL2

GO:0008285

negative regulation of cell proliferation

19436308


check buttonFusion gene breakpoints across PTPN6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LEPREL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3NA-01APTPN6chr12

7066948

-LEPREL2chr12

6948164

+
ChimerDB4BLCATCGA-FD-A3NA-01APTPN6chr12

7066948

+LEPREL2chr12

6948164

+


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Fusion Gene ORF analysis for PTPN6-LEPREL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000318974ENST00000538102PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
5CDS-intronENST00000399448ENST00000538102PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
5CDS-intronENST00000447931ENST00000538102PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
5CDS-intronENST00000456013ENST00000538102PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000318974ENST00000251761PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000318974ENST00000396725PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000318974ENST00000606935PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000399448ENST00000251761PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000399448ENST00000396725PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000399448ENST00000606935PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000447931ENST00000251761PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000447931ENST00000396725PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000447931ENST00000606935PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000456013ENST00000251761PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000456013ENST00000396725PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
In-frameENST00000456013ENST00000606935PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
intron-3CDSENST00000539029ENST00000251761PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
intron-3CDSENST00000539029ENST00000396725PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
intron-3CDSENST00000539029ENST00000606935PTPN6chr12

7066948

+LEPREL2chr12

6948164

+
intron-intronENST00000539029ENST00000538102PTPN6chr12

7066948

+LEPREL2chr12

6948164

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399448PTPN6chr127066948+ENST00000396725LEPREL2chr126948164+20601361411666541
ENST00000399448PTPN6chr127066948+ENST00000251761LEPREL2chr126948164+20601361411666541
ENST00000399448PTPN6chr127066948+ENST00000606935LEPREL2chr126948164+16671361411666542
ENST00000447931PTPN6chr127066948+ENST00000396725LEPREL2chr126948164+1904120581510500
ENST00000447931PTPN6chr127066948+ENST00000251761LEPREL2chr126948164+1904120581510500
ENST00000447931PTPN6chr127066948+ENST00000606935LEPREL2chr126948164+1511120581510501
ENST00000318974PTPN6chr127066948+ENST00000396725LEPREL2chr126948164+214914501691755528
ENST00000318974PTPN6chr127066948+ENST00000251761LEPREL2chr126948164+214914501691755528
ENST00000318974PTPN6chr127066948+ENST00000606935LEPREL2chr126948164+175614501691755529
ENST00000456013PTPN6chr127066948+ENST00000396725LEPREL2chr126948164+214714481671753528
ENST00000456013PTPN6chr127066948+ENST00000251761LEPREL2chr126948164+214714481671753528
ENST00000456013PTPN6chr127066948+ENST00000606935LEPREL2chr126948164+175414481671753529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399448ENST00000396725PTPN6chr127066948+LEPREL2chr126948164+0.0084987530.9915012
ENST00000399448ENST00000251761PTPN6chr127066948+LEPREL2chr126948164+0.0084987530.9915012
ENST00000399448ENST00000606935PTPN6chr127066948+LEPREL2chr126948164+0.0085671710.9914328
ENST00000447931ENST00000396725PTPN6chr127066948+LEPREL2chr126948164+0.0102300690.98976994
ENST00000447931ENST00000251761PTPN6chr127066948+LEPREL2chr126948164+0.0102300690.98976994
ENST00000447931ENST00000606935PTPN6chr127066948+LEPREL2chr126948164+0.0102216910.98977834
ENST00000318974ENST00000396725PTPN6chr127066948+LEPREL2chr126948164+0.0096018720.99039817
ENST00000318974ENST00000251761PTPN6chr127066948+LEPREL2chr126948164+0.0096018720.99039817
ENST00000318974ENST00000606935PTPN6chr127066948+LEPREL2chr126948164+0.0100986970.9899013
ENST00000456013ENST00000396725PTPN6chr127066948+LEPREL2chr126948164+0.0097044750.9902955
ENST00000456013ENST00000251761PTPN6chr127066948+LEPREL2chr126948164+0.0097044750.9902955
ENST00000456013ENST00000606935PTPN6chr127066948+LEPREL2chr126948164+0.0102454530.9897545

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Fusion Genomic Features for PTPN6-LEPREL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPN6chr127066948+LEPREL2chr126948163+0.729339240.2706608
PTPN6chr127066948+LEPREL2chr126948163+0.729339240.2706608

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTPN6-LEPREL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:7066948/chr12:6948164)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN6chr12:7066948chr12:6948164ENST00000318974+1016110_213402574.6666666666666DomainSH2 2
HgenePTPN6chr12:7066948chr12:6948164ENST00000318974+10164_100402574.6666666666666DomainSH2 1
HgenePTPN6chr12:7066948chr12:6948164ENST00000399448+1016110_213404607.3333333333334DomainSH2 2
HgenePTPN6chr12:7066948chr12:6948164ENST00000399448+10164_100404607.3333333333334DomainSH2 1
HgenePTPN6chr12:7066948chr12:6948164ENST00000447931+915110_213363566.6666666666666DomainSH2 2
HgenePTPN6chr12:7066948chr12:6948164ENST00000447931+9154_100363566.6666666666666DomainSH2 1
HgenePTPN6chr12:7066948chr12:6948164ENST00000456013+1016110_213402605.3333333333334DomainSH2 2
HgenePTPN6chr12:7066948chr12:6948164ENST00000456013+10164_100402605.3333333333334DomainSH2 1
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215681_709450552.0Coiled coilOntology_term=ECO:0000255
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215696_704450552.0Compositional biasNote=Poly-Glu
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215561_675450552.0DomainFe2OG dioxygenase
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215733_736450552.0MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN6chr12:7066948chr12:6948164ENST00000318974+1016244_515402574.6666666666666DomainTyrosine-protein phosphatase
HgenePTPN6chr12:7066948chr12:6948164ENST00000399448+1016244_515404607.3333333333334DomainTyrosine-protein phosphatase
HgenePTPN6chr12:7066948chr12:6948164ENST00000447931+915244_515363566.6666666666666DomainTyrosine-protein phosphatase
HgenePTPN6chr12:7066948chr12:6948164ENST00000456013+1016244_515402605.3333333333334DomainTyrosine-protein phosphatase
HgenePTPN6chr12:7066948chr12:6948164ENST00000318974+1016453_459402574.6666666666666RegionSubstrate binding
HgenePTPN6chr12:7066948chr12:6948164ENST00000399448+1016453_459404607.3333333333334RegionSubstrate binding
HgenePTPN6chr12:7066948chr12:6948164ENST00000447931+915453_459363566.6666666666666RegionSubstrate binding
HgenePTPN6chr12:7066948chr12:6948164ENST00000456013+1016453_459402605.3333333333334RegionSubstrate binding
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215173_177450552.0Compositional biasNote=Poly-Ala
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215267_270450552.0Compositional biasNote=Poly-Glu
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215154_187450552.0RepeatNote=TPR 2
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215216_249450552.0RepeatNote=TPR 3
TgeneLEPREL2chr12:7066948chr12:6948164ENST000002517611215316_349450552.0RepeatNote=TPR 4
TgeneLEPREL2chr12:7066948chr12:6948164ENST00000251761121537_70450552.0RepeatNote=TPR 1


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Fusion Gene Sequence for PTPN6-LEPREL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70290_70290_1_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000318974_LEPREL2_chr12_6948164_ENST00000251761_length(transcript)=2149nt_BP=1450nt
GTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGGTCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGT
GGAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGCACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCT
GCCTGCCCAGACTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACCGAGACCT
CAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTT
CTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTT
TGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCC
GCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGA
GCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGG
CTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGA
CCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAA
TGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTGA
GAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACAT
TCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGAA
CCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGC
GTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGGG
CATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCC
GCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGAC
TCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGCA
GGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGGT
CCAAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTTGAGGATGTGGCCACTTGACTTGTGG
AAGGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGCTCTCTGTCCCTGCACCCCCACCATC
TTGGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCCTGGGGAGCTGGGACGGGGCCCCGCT
GCCGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAGGAGGCTGATGCTTTAAATGAAGAGG

>70290_70290_1_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000318974_LEPREL2_chr12_6948164_ENST00000251761_length(amino acids)=528AA_BP=427
MSSLPAQTSCTSSFPAPPSSPEAPRMVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYG
GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK
AGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFW
EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF
WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGV

--------------------------------------------------------------
>70290_70290_2_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000318974_LEPREL2_chr12_6948164_ENST00000396725_length(transcript)=2149nt_BP=1450nt
GTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGGTCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGT
GGAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGCACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCT
GCCTGCCCAGACTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACCGAGACCT
CAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTT
CTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTT
TGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCC
GCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGA
GCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGG
CTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGA
CCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAA
TGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTGA
GAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACAT
TCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGAA
CCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGC
GTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGGG
CATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCC
GCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGAC
TCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGCA
GGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGGT
CCAAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTTGAGGATGTGGCCACTTGACTTGTGG
AAGGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGCTCTCTGTCCCTGCACCCCCACCATC
TTGGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCCTGGGGAGCTGGGACGGGGCCCCGCT
GCCGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAGGAGGCTGATGCTTTAAATGAAGAGG

>70290_70290_2_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000318974_LEPREL2_chr12_6948164_ENST00000396725_length(amino acids)=528AA_BP=427
MSSLPAQTSCTSSFPAPPSSPEAPRMVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYG
GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK
AGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFW
EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF
WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGV

--------------------------------------------------------------
>70290_70290_3_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000318974_LEPREL2_chr12_6948164_ENST00000606935_length(transcript)=1756nt_BP=1450nt
GTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGGTCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGT
GGAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGCACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCT
GCCTGCCCAGACTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACCGAGACCT
CAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTT
CTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTT
TGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCC
GCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGA
GCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGG
CTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGA
CCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAA
TGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTGA
GAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACAT
TCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGAA
CCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGC
GTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGGG
CATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCC
GCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGAC
TCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGCA
GGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGGT

>70290_70290_3_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000318974_LEPREL2_chr12_6948164_ENST00000606935_length(amino acids)=529AA_BP=427
MSSLPAQTSCTSSFPAPPSSPEAPRMVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYG
GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK
AGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFW
EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF
WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGV

--------------------------------------------------------------
>70290_70290_4_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000399448_LEPREL2_chr12_6948164_ENST00000251761_length(transcript)=2060nt_BP=1361nt
ATTGGCCTGGCAGGCAGGATCGAGGAGGAAGTGGCTGATTACTGAGCGGTTCTTCCTCACCTGGCTTGGGCCACTGTGCACAGCTGTGCC
GCTGGCTCAGCCCCGCCCCCTGCGGCCCTCTGCCGTGGCTTCCCCCTCCCTACAGAGAGATGCTGTCCCGTGGGTGGTTTCACCGAGACC
TCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACT
TCTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGT
TTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACC
CGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCG
AGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAG
GCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGG
ACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGA
ATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTG
AGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACA
TTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGA
ACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGG
CGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGG
GCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCC
CGCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGA
CTCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGC
AGGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGG
TCCAAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTTGAGGATGTGGCCACTTGACTTGTG
GAAGGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGCTCTCTGTCCCTGCACCCCCACCAT
CTTGGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCCTGGGGAGCTGGGACGGGGCCCCGC
TGCCGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAGGAGGCTGATGCTTTAAATGAAGAG

>70290_70290_4_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000399448_LEPREL2_chr12_6948164_ENST00000251761_length(amino acids)=541AA_BP=440
MSGSSSPGLGHCAQLCRWLSPAPCGPLPWLPPPYREMLSRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHI
RIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQP
GDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNK
KQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI
ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRL
VAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREE

--------------------------------------------------------------
>70290_70290_5_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000399448_LEPREL2_chr12_6948164_ENST00000396725_length(transcript)=2060nt_BP=1361nt
ATTGGCCTGGCAGGCAGGATCGAGGAGGAAGTGGCTGATTACTGAGCGGTTCTTCCTCACCTGGCTTGGGCCACTGTGCACAGCTGTGCC
GCTGGCTCAGCCCCGCCCCCTGCGGCCCTCTGCCGTGGCTTCCCCCTCCCTACAGAGAGATGCTGTCCCGTGGGTGGTTTCACCGAGACC
TCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACT
TCTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGT
TTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACC
CGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCG
AGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAG
GCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGG
ACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGA
ATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTG
AGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACA
TTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGA
ACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGG
CGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGG
GCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCC
CGCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGA
CTCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGC
AGGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGG
TCCAAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTTGAGGATGTGGCCACTTGACTTGTG
GAAGGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGCTCTCTGTCCCTGCACCCCCACCAT
CTTGGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCCTGGGGAGCTGGGACGGGGCCCCGC
TGCCGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAGGAGGCTGATGCTTTAAATGAAGAG

>70290_70290_5_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000399448_LEPREL2_chr12_6948164_ENST00000396725_length(amino acids)=541AA_BP=440
MSGSSSPGLGHCAQLCRWLSPAPCGPLPWLPPPYREMLSRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHI
RIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQP
GDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNK
KQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI
ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRL
VAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREE

--------------------------------------------------------------
>70290_70290_6_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000399448_LEPREL2_chr12_6948164_ENST00000606935_length(transcript)=1667nt_BP=1361nt
ATTGGCCTGGCAGGCAGGATCGAGGAGGAAGTGGCTGATTACTGAGCGGTTCTTCCTCACCTGGCTTGGGCCACTGTGCACAGCTGTGCC
GCTGGCTCAGCCCCGCCCCCTGCGGCCCTCTGCCGTGGCTTCCCCCTCCCTACAGAGAGATGCTGTCCCGTGGGTGGTTTCACCGAGACC
TCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACT
TCTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGT
TTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACC
CGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCG
AGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAG
GCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGG
ACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGA
ATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTG
AGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACA
TTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGA
ACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGG
CGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGG
GCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCC
CGCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGA
CTCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGC
AGGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGG

>70290_70290_6_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000399448_LEPREL2_chr12_6948164_ENST00000606935_length(amino acids)=542AA_BP=440
MSGSSSPGLGHCAQLCRWLSPAPCGPLPWLPPPYREMLSRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHI
RIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQP
GDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNK
KQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI
ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRL
VAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREE

--------------------------------------------------------------
>70290_70290_7_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000447931_LEPREL2_chr12_6948164_ENST00000251761_length(transcript)=1904nt_BP=1205nt
GCTGATTACTGAGCGGTTCTTCCTCACCTGGCTTGGGCCACTGTGCACAGCTGTGCCGCTGGCTCAGCCCCGCCCCCTGCGGCCCTCTGC
CGTGGCTTCCCCCTCCCTACAGAGAGATGCTGTCCCGTGGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCT
ATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACG
GCACCATCATCCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAG
AGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCA
GTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTT
TGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGC
AGCCGTACTATGCCACGAGGGTGAATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCA
AGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACA
AGGGCAAGAACCGCTACAAGAACATTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACT
ACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCA
CGGTCAATGACTTCTGGCAGATGGCGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAAT
GCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACA
AACTCCGTACCTTACAGGTCTCCCCGCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGA
ATCCCCATGGGGTGTGGGCCGTGACTCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGT
GGATAGAAGCCAAAGAACTGCTGCAGGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGC
CCCCTAGCCGCAGGCACCAGAGGGTCCAAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTT
GAGGATGTGGCCACTTGACTTGTGGAAGGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGC
TCTCTGTCCCTGCACCCCCACCATCTTGGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCC
TGGGGAGCTGGGACGGGGCCCCGCTGCCGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAG
GAGGCTGATGCTTTAAATGAAGAGGATGGTGGGGTTGGGAGGTATAACCCTGCTCCTCTCTCCCAGTCTGTGCAATAAAGGTCGTGAAGA

>70290_70290_7_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000447931_LEPREL2_chr12_6948164_ENST00000251761_length(amino acids)=500AA_BP=399
MSGSSSPGLGHCAQLCRWLSPAPCGPLPWLPPPYREMLSRGVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTI
IHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLET
FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGK
NRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP
YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIE

--------------------------------------------------------------
>70290_70290_8_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000447931_LEPREL2_chr12_6948164_ENST00000396725_length(transcript)=1904nt_BP=1205nt
GCTGATTACTGAGCGGTTCTTCCTCACCTGGCTTGGGCCACTGTGCACAGCTGTGCCGCTGGCTCAGCCCCGCCCCCTGCGGCCCTCTGC
CGTGGCTTCCCCCTCCCTACAGAGAGATGCTGTCCCGTGGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCT
ATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACG
GCACCATCATCCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAG
AGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCA
GTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTT
TGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGC
AGCCGTACTATGCCACGAGGGTGAATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCA
AGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACA
AGGGCAAGAACCGCTACAAGAACATTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACT
ACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCA
CGGTCAATGACTTCTGGCAGATGGCGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAAT
GCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACA
AACTCCGTACCTTACAGGTCTCCCCGCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGA
ATCCCCATGGGGTGTGGGCCGTGACTCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGT
GGATAGAAGCCAAAGAACTGCTGCAGGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGC
CCCCTAGCCGCAGGCACCAGAGGGTCCAAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTT
GAGGATGTGGCCACTTGACTTGTGGAAGGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGC
TCTCTGTCCCTGCACCCCCACCATCTTGGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCC
TGGGGAGCTGGGACGGGGCCCCGCTGCCGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAG
GAGGCTGATGCTTTAAATGAAGAGGATGGTGGGGTTGGGAGGTATAACCCTGCTCCTCTCTCCCAGTCTGTGCAATAAAGGTCGTGAAGA

>70290_70290_8_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000447931_LEPREL2_chr12_6948164_ENST00000396725_length(amino acids)=500AA_BP=399
MSGSSSPGLGHCAQLCRWLSPAPCGPLPWLPPPYREMLSRGVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTI
IHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLET
FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGK
NRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP
YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIE

--------------------------------------------------------------
>70290_70290_9_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000447931_LEPREL2_chr12_6948164_ENST00000606935_length(transcript)=1511nt_BP=1205nt
GCTGATTACTGAGCGGTTCTTCCTCACCTGGCTTGGGCCACTGTGCACAGCTGTGCCGCTGGCTCAGCCCCGCCCCCTGCGGCCCTCTGC
CGTGGCTTCCCCCTCCCTACAGAGAGATGCTGTCCCGTGGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCT
ATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACG
GCACCATCATCCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAG
AGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCA
GTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTT
TGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGC
AGCCGTACTATGCCACGAGGGTGAATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCA
AGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACA
AGGGCAAGAACCGCTACAAGAACATTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACT
ACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCA
CGGTCAATGACTTCTGGCAGATGGCGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAAT
GCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACA
AACTCCGTACCTTACAGGTCTCCCCGCTGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGA
ATCCCCATGGGGTGTGGGCCGTGACTCGGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGT
GGATAGAAGCCAAAGAACTGCTGCAGGAGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGC

>70290_70290_9_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000447931_LEPREL2_chr12_6948164_ENST00000606935_length(amino acids)=501AA_BP=399
MSGSSSPGLGHCAQLCRWLSPAPCGPLPWLPPPYREMLSRGVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTI
IHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLET
FDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGK
NRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP
YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIE

--------------------------------------------------------------
>70290_70290_10_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000456013_LEPREL2_chr12_6948164_ENST00000251761_length(transcript)=2147nt_BP=1448nt
GCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGGTCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTGG
AGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGCACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGC
CTGCCCAGACTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACCGAGACCTCA
GTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCT
CGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTTTG
CGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGC
TGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGC
CCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCT
CCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGACC
TGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAATG
CGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTGAGA
GTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACATTC
TCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGAACC
AGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGCGT
GGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGGGCA
TGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCCGC
TGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGACTC
GGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGCAGG
AGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGGTCC
AAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTTGAGGATGTGGCCACTTGACTTGTGGAA
GGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGCTCTCTGTCCCTGCACCCCCACCATCTT
GGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCCTGGGGAGCTGGGACGGGGCCCCGCTGC
CGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAGGAGGCTGATGCTTTAAATGAAGAGGAT

>70290_70290_10_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000456013_LEPREL2_chr12_6948164_ENST00000251761_length(amino acids)=528AA_BP=427
MSSLPAQTSCTSSFPAPPSSPEAPRMVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYG
GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK
AGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFW
EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF
WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGV

--------------------------------------------------------------
>70290_70290_11_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000456013_LEPREL2_chr12_6948164_ENST00000396725_length(transcript)=2147nt_BP=1448nt
GCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGGTCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTGG
AGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGCACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGC
CTGCCCAGACTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACCGAGACCTCA
GTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCT
CGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTTTG
CGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGC
TGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGC
CCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCT
CCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGACC
TGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAATG
CGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTGAGA
GTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACATTC
TCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGAACC
AGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGCGT
GGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGGGCA
TGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCCGC
TGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGACTC
GGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGCAGG
AGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGGTCC
AAGACAAGACTGGAAGGGCACCTCGGGTTCGGGAGGAGCTGTGAGTGGCTGAGCCAGCTCCTTGAGGATGTGGCCACTTGACTTGTGGAA
GGCCATCTTGATGCCAGGACACACAGGAAGCCCCTGTGTGACATCAGGAGCAGAACAGCAAGCTCTCTGTCCCTGCACCCCCACCATCTT
GGGGACCTACAAGGGCCTGGACTCAGAGGACAGTGCACAGGCTAGCCTGGAGCTCACCAGGCCTGGGGAGCTGGGACGGGGCCCCGCTGC
CGGACCTGCAGCCCTGGACAGATGGGGAACACTGTGCCTCCCTGAACAGAAATGGCAGGGGAGGAGGCTGATGCTTTAAATGAAGAGGAT

>70290_70290_11_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000456013_LEPREL2_chr12_6948164_ENST00000396725_length(amino acids)=528AA_BP=427
MSSLPAQTSCTSSFPAPPSSPEAPRMVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYG
GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK
AGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFW
EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF
WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGV

--------------------------------------------------------------
>70290_70290_12_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000456013_LEPREL2_chr12_6948164_ENST00000606935_length(transcript)=1754nt_BP=1448nt
GCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGGTCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTGG
AGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGCACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGC
CTGCCCAGACTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCCAGGATGGTGAGGTGGTTTCACCGAGACCTCA
GTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCT
CGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTTTG
CGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGC
TGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGC
CCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCT
CCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGACC
TGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAATG
CGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCCAAGGCTGGCTTCTGGGAGGAGTTTGAGA
GTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACATTC
TCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGACTACATCAATGCCAACTACATCAAGAACC
AGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGCGT
GGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAATGCGTCCCATACTGGCCCGAGGTGGGCA
TGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCCGC
TGGACAATGCTCGGGTGCGTCCTCGCTGTGGGCGCCTTGTGGCCTTCAGCTCCGGTGTCGAGAATCCCCATGGGGTGTGGGCCGTGACTC
GGGGACGGCGCTGTGCCCTGGCACTGTGGCACACGTGGGCACCTGAGCACAGGGAGCAGGAGTGGATAGAAGCCAAAGAACTGCTGCAGG
AGTCACAGGAGGAGGAGGAAGAGGAAGAGGAAGAAATGCCCAGCAAAGACCCTTCCCCAGAGCCCCCTAGCCGCAGGCACCAGAGGGTCC

>70290_70290_12_PTPN6-LEPREL2_PTPN6_chr12_7066948_ENST00000456013_LEPREL2_chr12_6948164_ENST00000606935_length(amino acids)=529AA_BP=427
MSSLPAQTSCTSSFPAPPSSPEAPRMVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYG
GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK
AGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFW
EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDF
WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNARVRPRCGRLVAFSSGVENPHGV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTPN6-LEPREL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPN6-LEPREL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPN6-LEPREL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource