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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPN9-SLC12A1 (FusionGDB2 ID:70309)

Fusion Gene Summary for PTPN9-SLC12A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN9-SLC12A1
Fusion gene ID: 70309
HgeneTgene
Gene symbol

PTPN9

SLC12A1

Gene ID

5780

6557

Gene nameprotein tyrosine phosphatase non-receptor type 9solute carrier family 12 member 1
SynonymsMEG2|PTPMEG2BSC1|NKCC2
Cytomap

15q24.2

15q21.1

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2solute carrier family 12 member 1NKCC2A variant ANa-K-2Cl cotransporterbumetanide-sensitive sodium-(potassium)-chloride cotransporter 2kidney-specific Na-K-Cl symportersolute carrier family 12 (sodium/potassium/chloride transporter), member 1solute
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306726, ENST00000564970, 
ENST00000330289, ENST00000558405, 
ENST00000559723, ENST00000561031, 
ENST00000380993, ENST00000396577, 
Fusion gene scores* DoF score14 X 13 X 7=12746 X 7 X 5=210
# samples 167
** MAII scorelog2(16/1274*10)=-2.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN9 [Title/Abstract] AND SLC12A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPN9(75871055)-SLC12A1(48541772), # samples:1
PTPN9(75871055)-SLC12A1(48539534), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPN9-SLC12A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPN9-SLC12A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN9

GO:0010977

negative regulation of neuron projection development

27655914

HgenePTPN9

GO:0035335

peptidyl-tyrosine dephosphorylation

27655914

HgenePTPN9

GO:1903078

positive regulation of protein localization to plasma membrane

27655914


check buttonFusion gene breakpoints across PTPN9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC12A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BM-01APTPN9chr15

75871055

-SLC12A1chr15

48539534

+
ChimerDB4SARCTCGA-DX-A8BM-01APTPN9chr15

75871055

-SLC12A1chr15

48541772

+


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Fusion Gene ORF analysis for PTPN9-SLC12A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306726ENST00000330289PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
5CDS-intronENST00000306726ENST00000330289PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
5CDS-intronENST00000306726ENST00000558405PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
5CDS-intronENST00000306726ENST00000558405PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
5CDS-intronENST00000306726ENST00000559723PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
5CDS-intronENST00000306726ENST00000559723PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
5CDS-intronENST00000306726ENST00000561031PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
5CDS-intronENST00000306726ENST00000561031PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
Frame-shiftENST00000306726ENST00000380993PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
Frame-shiftENST00000306726ENST00000396577PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
In-frameENST00000306726ENST00000380993PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
In-frameENST00000306726ENST00000396577PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-3CDSENST00000564970ENST00000380993PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-3CDSENST00000564970ENST00000380993PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
intron-3CDSENST00000564970ENST00000396577PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-3CDSENST00000564970ENST00000396577PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
intron-intronENST00000564970ENST00000330289PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-intronENST00000564970ENST00000330289PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
intron-intronENST00000564970ENST00000558405PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-intronENST00000564970ENST00000558405PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
intron-intronENST00000564970ENST00000559723PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-intronENST00000564970ENST00000559723PTPN9chr15

75871055

-SLC12A1chr15

48541772

+
intron-intronENST00000564970ENST00000561031PTPN9chr15

75871055

-SLC12A1chr15

48539534

+
intron-intronENST00000564970ENST00000561031PTPN9chr15

75871055

-SLC12A1chr15

48541772

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306726PTPN9chr1575871055-ENST00000380993SLC12A1chr1548539534+35075763842315643
ENST00000306726PTPN9chr1575871055-ENST00000396577SLC12A1chr1548539534+35095763842315643

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306726ENST00000380993PTPN9chr1575871055-SLC12A1chr1548539534+0.0004403410.9995597
ENST00000306726ENST00000396577PTPN9chr1575871055-SLC12A1chr1548539534+0.0004429790.99955696

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Fusion Genomic Features for PTPN9-SLC12A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPN9chr1575871054-SLC12A1chr1548541771+5.70E-060.9999943
PTPN9chr1575871054-SLC12A1chr1548539533+1.39E-060.99999857
PTPN9chr1575871054-SLC12A1chr1548541771+5.70E-060.9999943
PTPN9chr1575871054-SLC12A1chr1548539533+1.39E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PTPN9-SLC12A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:75871055/chr15:48541772)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127593_6095201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127814_10995201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026593_6095201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026814_10995201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127551_5715201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127572_5925201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127610_6305201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127793_8135201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026551_5715201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026572_5925201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026610_6305201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026793_8135201100.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN9chr15:75871055chr15:48539534ENST00000306726-113303_57421594.0DomainTyrosine-protein phosphatase
HgenePTPN9chr15:75871055chr15:48539534ENST00000306726-11384_24321594.0DomainCRAL-TRIO
HgenePTPN9chr15:75871055chr15:48539534ENST00000306726-113515_52121594.0RegionSubstrate binding
TgeneSLC12A1chr15:75871055chr15:48539534ENST0000038099311271_1775201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127223_2595201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127324_3275201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127401_4175201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127506_5505201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST0000055840510261_1775201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026223_2595201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026324_3275201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026401_4175201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026506_5505201100.0Topological domainCytoplasmic
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127178_1985201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127202_2225201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127260_2805201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127303_3235201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127328_3485201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127380_4005201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127418_4385201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000003809931127485_5055201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026178_1985201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026202_2225201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026260_2805201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026303_3235201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026328_3485201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026380_4005201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026418_4385201100.0TransmembraneHelical
TgeneSLC12A1chr15:75871055chr15:48539534ENST000005584051026485_5055201100.0TransmembraneHelical


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Fusion Gene Sequence for PTPN9-SLC12A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70309_70309_1_PTPN9-SLC12A1_PTPN9_chr15_75871055_ENST00000306726_SLC12A1_chr15_48539534_ENST00000380993_length(transcript)=3507nt_BP=576nt
AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG
GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG
TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA
GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT
TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC
CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC
GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTCTGTGCAAGGACAACATCTACAAAGCCCTGCAGTTTTTTGCAAAGGGATAT
GGGAAAAACAATGAACCCCTGAGAGGATATATTCTCACTTTTCTTATAGCCATGGCATTTATTCTTATTGCGGAACTGAACACCATTGCT
CCCATCATCTCCAACTTTTTCCTGGCCTCATATGCACTTATTAATTTCTCCTGCTTCCATGCCTCTTATGCCAAATCTCCAGGATGGAGA
CCTGCGTATGGAATTTACAACATGTGGGTATCTCTTTTTGGAGCTGTTTTGTGCTGTGCAGTCATGTTTGTCATCAACTGGTGGGCAGCT
GTCATCACCTATGTCATTGAATTCTTCCTTTACGTCTATGTGACTTGTAAGAAGCCAGATGTGAACTGGGGCTCCTCCACACAGGCTCTT
TCCTACGTGAGTGCTTTAGACAATGCTCTGGAATTAACCACAGTGGAAGACCACGTAAAAAACTTCAGGCCCCAGTGCATTGTCTTAACA
GGGGGACCCATGACAAGACCTGCTCTCCTGGACATAACTCACGCCTTTACCAAGAACAGTGGCCTTTGCATCTGCTGTGAAGTCTTTGTG
GGACCGCGCAAACTGTGTGTTAAGGAGATGAACAGTGGCATGGCGAAAAAACAGGCCTGGCTTATAAAGAACAAAATCAAGGCTTTTTAT
GCTGCAGTGGCGGCAGACTGTTTCAGGGATGGTGTCCGAAGTCTTCTTCAGGCCTCAGGCTTAGGAAGAATGAAACCAAACACTCTGGTG
ATTGGATATAAGAAAAACTGGAGGAAAGCTCCCTTGACAGAGATTGAGAACTACGTGGGAATCATACATGATGCATTTGATTTTGAGATT
GGCGTGGTTATAGTCAGAATCAGCCAAGGATTTGACATCTCTCAGGTTCTTCAGGTGCAAGAGGAATTAGAGAGATTAGAACAGGAGAGA
CTAGCATTGGAAGCGACTATCAAAGATAATGAGTGTGAAGAGGAAAGTGGAGGCATCCGAGGCTTGTTTAAAAAAGCTGGCAAGTTGAAC
ATTACTAAGACAACGCCTAAAAAAGATGGCAGCATTAACACAAGCCAGTCGATGCATGTGGGAGAGTTCAACCAGAAACTGGTGGAAGCC
AGCACTCAATTTAAAAAGAAACAAGAAAAAGGCACAATTGATGTTTGGTGGTTGTTTGATGATGGAGGGTTAACACTTCTTATCCCCTAT
ATCTTAACTCTCAGAAAAAAATGGAAAGACTGTAAATTAAGAATCTATGTGGGAGGGAAGATCAACCGCATTGAAGAAGAAAAAATTGTA
ATGGCTTCCCTTCTGAGCAAATTTAGGATAAAATTTGCAGACATCCATATCATCGGTGACATCAACATTAGGCCAAACAAAGAGAGCTGG
AAAGTCTTTGAAGAGATGATTGAACCATATCGTCTCCATGAAAGCTGCAAAGATTTAACAACTGCTGAGAAATTAAAAAGAGAAACTCCG
TGGAAAATTACAGATGCAGAACTGGAAGCAGTCAAGGAAAAGAGTTACCGCCAAGTTCGACTGAATGAACTCTTACAGGAGCACTCCAGA
GCTGCTAATCTCATTGTCCTGAGCCTTCCCGTGGCAAGAAAGGGATCCATATCGGATTTGTTGTATATGGCTTGGTTGGAAATCCTCACA
AAGAACCTCCCACCTGTCTTACTAGTTAGAGGAAATCACAAAAATGTCTTGACATTTTACTCTTAAAACATGAAAGATTGGAATACATTT
TAACTTAATGTAATGCATAATTAAGAAACATGTTCCAGTACTTTATGTTGTAAATCTGATCTATGGATATGCAAACCTCTGGAGAGGATC
CTACCAGATTCTACATACATTGCATAATTTTTATCAGTTAATGCGAGCTTTTTTTTCTCTTCTCAGCTTAAGGGGTTGTCAAAGCCAATG
TTATCCCTAGAAAAACATTTTTGTCACTGCTGTTGATAAACAAGAAAATCAAGGAAACTCATGTTGGCTTATGCTCATGAAAACCACCAA
TGTGATTGTAAACTTCTCCAGACAAACTTAACCTTTTGTTTCTTAATTTTTTGTTTTGAGTGTTTGCTTCTCAGCCCTGGTATAGGTCTC
AGCCCCACAGCAGGATCTCAATAAATGCTTATTGACAGGCTGGCATAGTAACCACAGGTGGTTATCAAAGGAAAAGACCAATAGGCTGGG
GAACATAATTATGCTTGGCCCCCTCAGAGGCTTATACCTCCAAAGCAGATTTAAAAATCAGTAACTCAAAACTTTAAGAAGTAGTTGAGT
CTACAAAATATTCAAAGCAGTTACCTAAATAAGGTTATTTAATGTAACAGATTATATACTTAAAGTGATCTGAGCAATCATTGATAACAT
ATGGCTTAAATTTGCTGCTGCCTGAAAAGTATATTAACTAGATTAGAAGACACCATATACTCCAATAAAATGAAATATATTCTATTCTCA
ATATATAAACTTTAATTGTACTCCCTATCAAATATTTTGAAATTTCCATCACGGCATTACTTTGCATATTTTTTTCTAATTAAATGGTTA
GTACAGATGAAATCTTTATAGATGACTACTTGAAAACTAAGTGCTACAAATTTTCAAACCATTATTAAGAAATATATCCTGAATCATATA
TTTAGTTACTTTCTATAGTGATTGTATGGATTTAAAAGAATAATTAAAATGTGAAGTTGAAAAACTTGTAAAATTTGGAATATACAGATA
CTGATTTTTTTCATTTTTGTTAGTATACCTATAATACATAATCACATTGACAAACCAATGAAAATATTGATTTTCTGATGAATGGCTTGA

>70309_70309_1_PTPN9-SLC12A1_PTPN9_chr15_75871055_ENST00000306726_SLC12A1_chr15_48539534_ENST00000380993_length(amino acids)=643AA_BP=64
MPATLCASRPRAAEARGRGSGGRARRAPALASEFCPPGGGGGGMEPATAPRPDMAPELTPEEEQALCKDNIYKALQFFAKGYGKNNEPLR
GYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEF
FLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVK
EMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRIS
QGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQ
EKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIE
PYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLL

--------------------------------------------------------------
>70309_70309_2_PTPN9-SLC12A1_PTPN9_chr15_75871055_ENST00000306726_SLC12A1_chr15_48539534_ENST00000396577_length(transcript)=3509nt_BP=576nt
AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG
GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG
TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA
GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT
TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC
CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC
GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTCTGTGCAAGGACAACATCTACAAAGCCCTGCAGTTTTTTGCAAAGGGATAT
GGGAAAAACAATGAACCCCTGAGAGGATATATTCTCACTTTTCTTATAGCCATGGCATTTATTCTTATTGCGGAACTGAACACCATTGCT
CCCATCATCTCCAACTTTTTCCTGGCCTCATATGCACTTATTAATTTCTCCTGCTTCCATGCCTCTTATGCCAAATCTCCAGGATGGAGA
CCTGCGTATGGAATTTACAACATGTGGGTATCTCTTTTTGGAGCTGTTTTGTGCTGTGCAGTCATGTTTGTCATCAACTGGTGGGCAGCT
GTCATCACCTATGTCATTGAATTCTTCCTTTACGTCTATGTGACTTGTAAGAAGCCAGATGTGAACTGGGGCTCCTCCACACAGGCTCTT
TCCTACGTGAGTGCTTTAGACAATGCTCTGGAATTAACCACAGTGGAAGACCACGTAAAAAACTTCAGGCCCCAGTGCATTGTCTTAACA
GGGGGACCCATGACAAGACCTGCTCTCCTGGACATAACTCACGCCTTTACCAAGAACAGTGGCCTTTGCATCTGCTGTGAAGTCTTTGTG
GGACCGCGCAAACTGTGTGTTAAGGAGATGAACAGTGGCATGGCGAAAAAACAGGCCTGGCTTATAAAGAACAAAATCAAGGCTTTTTAT
GCTGCAGTGGCGGCAGACTGTTTCAGGGATGGTGTCCGAAGTCTTCTTCAGGCCTCAGGCTTAGGAAGAATGAAACCAAACACTCTGGTG
ATTGGATATAAGAAAAACTGGAGGAAAGCTCCCTTGACAGAGATTGAGAACTACGTGGGAATCATACATGATGCATTTGATTTTGAGATT
GGCGTGGTTATAGTCAGAATCAGCCAAGGATTTGACATCTCTCAGGTTCTTCAGGTGCAAGAGGAATTAGAGAGATTAGAACAGGAGAGA
CTAGCATTGGAAGCGACTATCAAAGATAATGAGTGTGAAGAGGAAAGTGGAGGCATCCGAGGCTTGTTTAAAAAAGCTGGCAAGTTGAAC
ATTACTAAGACAACGCCTAAAAAAGATGGCAGCATTAACACAAGCCAGTCGATGCATGTGGGAGAGTTCAACCAGAAACTGGTGGAAGCC
AGCACTCAATTTAAAAAGAAACAAGAAAAAGGCACAATTGATGTTTGGTGGTTGTTTGATGATGGAGGGTTAACACTTCTTATCCCCTAT
ATCTTAACTCTCAGAAAAAAATGGAAAGACTGTAAATTAAGAATCTATGTGGGAGGGAAGATCAACCGCATTGAAGAAGAAAAAATTGTA
ATGGCTTCCCTTCTGAGCAAATTTAGGATAAAATTTGCAGACATCCATATCATCGGTGACATCAACATTAGGCCAAACAAAGAGAGCTGG
AAAGTCTTTGAAGAGATGATTGAACCATATCGTCTCCATGAAAGCTGCAAAGATTTAACAACTGCTGAGAAATTAAAAAGAGAAACTCCG
TGGAAAATTACAGATGCAGAACTGGAAGCAGTCAAGGAAAAGAGTTACCGCCAAGTTCGACTGAATGAACTCTTACAGGAGCACTCCAGA
GCTGCTAATCTCATTGTCCTGAGCCTTCCCGTGGCAAGAAAGGGATCCATATCGGATTTGTTGTATATGGCTTGGTTGGAAATCCTCACA
AAGAACCTCCCACCTGTCTTACTAGTTAGAGGAAATCACAAAAATGTCTTGACATTTTACTCTTAAAACATGAAAGATTGGAATACATTT
TAACTTAATGTAATGCATAATTAAGAAACATGTTCCAGTACTTTATGTTGTAAATCTGATCTATGGATATGCAAACCTCTGGAGAGGATC
CTACCAGATTCTACATACATTGCATAATTTTTATCAGTTAATGCGAGCTTTTTTTTCTCTTCTCAGCTTAAGGGGTTGTCAAAGCCAATG
TTATCCCTAGAAAAACATTTTTGTCACTGCTGTTGATAAACAAGAAAATCAAGGAAACTCATGTTGGCTTATGCTCATGAAAACCACCAA
TGTGATTGTAAACTTCTCCAGACAAACTTAACCTTTTGTTTCTTAATTTTTTGTTTTGAGTGTTTGCTTCTCAGCCCTGGTATAGGTCTC
AGCCCCACAGCAGGATCTCAATAAATGCTTATTGACAGGCTGGCATAGTAACCACAGGTGGTTATCAAAGGAAAAGACCAATAGGCTGGG
GAACATAATTATGCTTGGCCCCCTCAGAGGCTTATACCTCCAAAGCAGATTTAAAAATCAGTAACTCAAAACTTTAAGAAGTAGTTGAGT
CTACAAAATATTCAAAGCAGTTACCTAAATAAGGTTATTTAATGTAACAGATTATATACTTAAAGTGATCTGAGCAATCATTGATAACAT
ATGGCTTAAATTTGCTGCTGCCTGAAAAGTATATTAACTAGATTAGAAGACACCATATACTCCAATAAAATGAAATATATTCTATTCTCA
ATATATAAACTTTAATTGTACTCCCTATCAAATATTTTGAAATTTCCATCACGGCATTACTTTGCATATTTTTTTCTAATTAAATGGTTA
GTACAGATGAAATCTTTATAGATGACTACTTGAAAACTAAGTGCTACAAATTTTCAAACCATTATTAAGAAATATATCCTGAATCATATA
TTTAGTTACTTTCTATAGTGATTGTATGGATTTAAAAGAATAATTAAAATGTGAAGTTGAAAAACTTGTAAAATTTGGAATATACAGATA
CTGATTTTTTTCATTTTTGTTAGTATACCTATAATACATAATCACATTGACAAACCAATGAAAATATTGATTTTCTGATGAATGGCTTGA

>70309_70309_2_PTPN9-SLC12A1_PTPN9_chr15_75871055_ENST00000306726_SLC12A1_chr15_48539534_ENST00000396577_length(amino acids)=643AA_BP=64
MPATLCASRPRAAEARGRGSGGRARRAPALASEFCPPGGGGGGMEPATAPRPDMAPELTPEEEQALCKDNIYKALQFFAKGYGKNNEPLR
GYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEF
FLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVK
EMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRIS
QGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQ
EKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIE
PYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLL

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Fusion Gene PPI Analysis for PTPN9-SLC12A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPN9-SLC12A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPN9-SLC12A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource