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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRG-FRMD4B (FusionGDB2 ID:70400)

Fusion Gene Summary for PTPRG-FRMD4B

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG-FRMD4B
Fusion gene ID: 70400
HgeneTgene
Gene symbol

PTPRG

FRMD4B

Gene ID

5793

23150

Gene nameprotein tyrosine phosphatase receptor type GFERM domain containing 4B
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPG6030440G05Rik|GRSP1
Cytomap

3p14.2

3p14.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tFERM domain-containing protein 4BGRP1-binding protein GRSP1
Modification date2020032720200313
UniProtAcc.

Q9Y2L6

Ensembl transtripts involved in fusion geneENST00000495879, ENST00000295874, 
ENST00000474889, 		ENST00000398540, 
ENST00000542259, ENST00000478263, 
ENST00000497757, 
Fusion gene scores* DoF score18 X 14 X 10=252012 X 12 X 10=1440
# samples 2214
** MAII scorelog2(22/2520*10)=-3.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1440*10)=-3.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRG [Title/Abstract] AND FRMD4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRG(61734656)-FRMD4B(69225807), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PTPRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FRMD4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-A9TH-01APTPRGchr3

61734656

-FRMD4Bchr3

69225807

-
ChimerDB4PRADTCGA-HC-A9TH-01APTPRGchr3

61734656

+FRMD4Bchr3

69225807

-


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Fusion Gene ORF analysis for PTPRG-FRMD4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000495879ENST00000398540PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
3UTR-3CDSENST00000495879ENST00000542259PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
3UTR-intronENST00000495879ENST00000478263PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
3UTR-intronENST00000495879ENST00000497757PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
5CDS-intronENST00000295874ENST00000478263PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
5CDS-intronENST00000295874ENST00000497757PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
5CDS-intronENST00000474889ENST00000478263PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
5CDS-intronENST00000474889ENST00000497757PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
In-frameENST00000295874ENST00000398540PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
In-frameENST00000295874ENST00000542259PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
In-frameENST00000474889ENST00000398540PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-
In-frameENST00000474889ENST00000542259PTPRGchr3

61734656

+FRMD4Bchr3

69225807

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295874PTPRGchr361734656+ENST00000398540FRMD4Bchr369225807-2692567188820210
ENST00000295874PTPRGchr361734656+ENST00000542259FRMD4Bchr369225807-2687567188820210
ENST00000474889PTPRGchr361734656+ENST00000398540FRMD4Bchr369225807-2692567188820210
ENST00000474889PTPRGchr361734656+ENST00000542259FRMD4Bchr369225807-2687567188820210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295874ENST00000398540PTPRGchr361734656+FRMD4Bchr369225807-0.0075736490.9924264
ENST00000295874ENST00000542259PTPRGchr361734656+FRMD4Bchr369225807-0.0077561380.9922438
ENST00000474889ENST00000398540PTPRGchr361734656+FRMD4Bchr369225807-0.0075736490.9924264
ENST00000474889ENST00000542259PTPRGchr361734656+FRMD4Bchr369225807-0.0077561380.9922438

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Fusion Genomic Features for PTPRG-FRMD4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRG-FRMD4B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:61734656/chr3:69225807)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FRMD4B

Q9Y2L6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+2291150_1410631417.0DomainTyrosine-protein phosphatase 2
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+229349_448631417.0DomainFibronectin type-III
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+22958_321631417.0DomainAlpha-carbonic anhydrase
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+229848_1119631417.0DomainTyrosine-protein phosphatase 1
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+2301150_1410631446.0DomainTyrosine-protein phosphatase 2
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+230349_448631446.0DomainFibronectin type-III
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+23058_321631446.0DomainAlpha-carbonic anhydrase
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+230848_1119631446.0DomainTyrosine-protein phosphatase 1
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+2291060_1066631417.0RegionSubstrate binding
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+2301060_1066631446.0RegionSubstrate binding
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+22920_736631417.0Topological domainExtracellular
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+229763_1445631417.0Topological domainCytoplasmic
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+23020_736631446.0Topological domainExtracellular
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+230763_1445631446.0Topological domainCytoplasmic
HgenePTPRGchr3:61734656chr3:69225807ENST00000295874+229737_762631417.0TransmembraneHelical
HgenePTPRGchr3:61734656chr3:69225807ENST00000474889+230737_762631446.0TransmembraneHelical
TgeneFRMD4Bchr3:61734656chr3:69225807ENST000003985402023417_4509501035.0Coiled coilOntology_term=ECO:0000255
TgeneFRMD4Bchr3:61734656chr3:69225807ENST000003985402023531_5619501035.0Coiled coilOntology_term=ECO:0000255
TgeneFRMD4Bchr3:61734656chr3:69225807ENST00000398540202359_3619501035.0DomainFERM
TgeneFRMD4Bchr3:61734656chr3:69225807ENST000003985402023542_9719501035.0RegionNecessary for adherens junction and tight junction localization


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Fusion Gene Sequence for PTPRG-FRMD4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70400_70400_1_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000295874_FRMD4B_chr3_69225807_ENST00000398540_length(transcript)=2692nt_BP=567nt
CTCAAGTTGGGGATCCTCGGCTGCTCGCCGCCGCCGCCCGCGGTCCCTGCCTGCCCCAGGCCCGGGGCATCGCCGCCGGCCGCCGACTCC
GCGCCCTGCCCGATCGGCTCTCTCCTTTTTAAACGGAAAGCAGCCTTTCTCCGCCGAGAGGATCGTCCCCAGCGTGGCTCTGCGTTCCCG
GTCACTTTTTGAGATTTTCCGGGGGGCGCTCGGCGGCTTCCCGGATTCCAAGGGGACTCGGGCCGCCGAGCGCGGGGGGCCCGTGGAGCG
GGCGAGCCGGGGAAGCGCCCCGGCTTAGCGGAGGCTCGCACGGAGGCAAGAACTTATTCAACAAGTTTACCTCCCTGCTTTCCTCTTTTC
GATGTGCGTTTTCGGACATGCGGAGGTTACTGGAACCGTGTTGGTGGATTTTGTTCCTGAAAATCACCAGTTCCGTGCTCCATTATGTCG
TGTGCTTCCCCGCGTTGACAGAAGGCTACGTTGGGGCCCTGCACGAGAATAGACACGGCAGCGCAGTGCAGATCCGCAGGCGCAAGGCTT
CAGGCGACCCGTACTGGGCCTACTCTGTGTCTTCTACAAATGCTTCTGGGAACTGGAGGACCCAGTTAACCATAGGGCTGTCGGATTACG
AGACTCCAGCACATTCTTCTTACACCAGCTGCTATGGCAATGTCTATAATCCTTTACCCTCTCCAAGCAGACAATACACAGAAATCAGTC
AACTGGATGGTACAGATGGAAACCAGCTGGAAGACAACCTGGAGAGTAGTGAGCAGAGACTCTTTTGGCATGAAGATTCAAAGCCTGGAA
CATTAGTCTGAACTGCAGTTGGACCTCCTGACCAAGCACTGCGTTCTCACACTAGTGTGCCTTGCAAATTGTATTTGTCTTCCGAGAGGA
TGTTCGTTTTAGAAACCTAAAGACATCAAAGGTTGAAGAGAAGACTTAGTTGCCCTGGAAGTGAATCAGTGAATCACACACCAAGCCCCA
CAAAGCCCCTAAAGGAGGATTTGGCCTTTCAAACTCTAGGCACTAACGTAACTGTAGGGTCTGCCCACATGTTGAAGTATTGCCAAGAGA
GGACTCAGTGTGAAGCCTTCATCAATAGCAAGCACTTTTTAAGGGAGTAAAAGTTGTTAAAGGCAAACCTCAAAAACATGAAAGGGCATT
CAGGATGTCCCATGGCAATAAGAACAGGGGAAATCTCAGAGCACAATTCAGCAGGATGAGAGAAGGGGAACCAGAAGCTCCGGAGTCATT
GCTCACTTCAGAGTTTGAATTCGTGAGCTGACAAAGAGTAACATGCTCTTTCTACACAGACATGGACAATTTAGACAGTATTGGAAAATT
ACTTGAAGCTGGATTTTCATGAAGTTCTGAATGAGTGTAAATGTTTTTTAGGATACTATAAAGAGTGATGTTTTTCATAAGCACCATAAA
ATGGGTTCTGGAAAAACTGATTACCTTAGCATCCTGTAATATAACTTATGGTAGCAGATTGGGGAAAATGAAGCAGCCCACTGAATAATT
GACAAAGTCTGCTTGGAGAACATTCTAAGGTACAATATCATGGAGCTCCTTTTTCCTTTCTCCACTAATTGCGTGATGAGCTATTGTTCT
GGCTGTTAATTCTCCAACTCGGCTGTCATTTGAAGTGGCAGACTTAATATGGAAAGTTTTTATAATTATGAGTTTGAAAAAGCATTTTAA
GATGATACAGAAAGTATCCAAAACAACAGAAAAAAAAAGCCACGTCATTTTAGATGAATTGCGTGCCTTAAAATGGTGAACGTTAGAAAA
TTAAACAAGTCTGGATTCCACAAGTAGTTCCAAGTCACCAAGTGACAAAAACAAGGTTAACATTAAAAAAGAAAAACAACAACAACGACA
AAAAGCTCCAAGCTGCAGTGGATTTAATTATGAGGCTAAAACTACCTCATACTTTCCTTGGAAGAACTAATTAGCTATGGTTTATTGTAG
GGTTTTGTTTGTTTGTTTTTTAAAGCAAATGATTTCCATATTCCAGATTGATCTTTTTTGTCATCTTTGCTTCAAAATTACATAAAAGGT
GCTCCTTTCCCCCTTCTTTTATACAAGTTTCTTGTTCATATTGTGAATAGAAAAGTTTCTGAACAACTTTTTTGGAACATTTTCTATCTA
TATTCCAAAGCATGTAATATATACATAAAAACGATTTGTTAAACTGGTCCTTAGTCATTTGTATAATTAGAAATGAAGTTTGGGAAAAAA
TTTTGGAAAAAAGACAAGCAAAAAAAAATAACTTATTCCTTTTTTGCATATTTGTATAGCCTTCTAGAATCAGAAATAACCTTTTTGCAT
ATTCTTTTATTGTTCTGACTTTTCAAGACCTATTATTTTTTTACATAGGTCAATAAACAAAAGGTGTGCTACTGAAAATGTTTACGTTTT
CTTCCATTTATGTCAGGGGTTCATGTGAAGCAGGTCGCAGTGCTCTACTTCAAGTAATCATATTGGGCAAGGCTTCGGATTTTTATTTAT
AGTATTACCGTATTTTATTAATTCCGGGATGTACATTTTTAAATATTTACATTAAAAACATGGTTCATCTTTTTATTGATGGCATATTCT

>70400_70400_1_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000295874_FRMD4B_chr3_69225807_ENST00000398540_length(amino acids)=210AA_BP=126
MRFSGGRSAASRIPRGLGPPSAGGPWSGRAGEAPRLSGGSHGGKNLFNKFTSLLSSFRCAFSDMRRLLEPCWWILFLKITSSVLHYVVCF
PALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLD

--------------------------------------------------------------
>70400_70400_2_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000295874_FRMD4B_chr3_69225807_ENST00000542259_length(transcript)=2687nt_BP=567nt
CTCAAGTTGGGGATCCTCGGCTGCTCGCCGCCGCCGCCCGCGGTCCCTGCCTGCCCCAGGCCCGGGGCATCGCCGCCGGCCGCCGACTCC
GCGCCCTGCCCGATCGGCTCTCTCCTTTTTAAACGGAAAGCAGCCTTTCTCCGCCGAGAGGATCGTCCCCAGCGTGGCTCTGCGTTCCCG
GTCACTTTTTGAGATTTTCCGGGGGGCGCTCGGCGGCTTCCCGGATTCCAAGGGGACTCGGGCCGCCGAGCGCGGGGGGCCCGTGGAGCG
GGCGAGCCGGGGAAGCGCCCCGGCTTAGCGGAGGCTCGCACGGAGGCAAGAACTTATTCAACAAGTTTACCTCCCTGCTTTCCTCTTTTC
GATGTGCGTTTTCGGACATGCGGAGGTTACTGGAACCGTGTTGGTGGATTTTGTTCCTGAAAATCACCAGTTCCGTGCTCCATTATGTCG
TGTGCTTCCCCGCGTTGACAGAAGGCTACGTTGGGGCCCTGCACGAGAATAGACACGGCAGCGCAGTGCAGATCCGCAGGCGCAAGGCTT
CAGGCGACCCGTACTGGGCCTACTCTGTGTCTTCTACAAATGCTTCTGGGAACTGGAGGACCCAGTTAACCATAGGGCTGTCGGATTACG
AGACTCCAGCACATTCTTCTTACACCAGCTGCTATGGCAATGTCTATAATCCTTTACCCTCTCCAAGCAGACAATACACAGAAATCAGTC
AACTGGATGGTACAGATGGAAACCAGCTGGAAGACAACCTGGAGAGTAGTGAGCAGAGACTCTTTTGGCATGAAGATTCAAAGCCTGGAA
CATTAGTCTGAACTGCAGTTGGACCTCCTGACCAAGCACTGCGTTCTCACACTAGTGTGCCTTGCAAATTGTATTTGTCTTCCGAGAGGA
TGTTCGTTTTAGAAACCTAAAGACATCAAAGGTTGAAGAGAAGACTTAGTTGCCCTGGAAGTGAATCAGTGAATCACACACCAAGCCCCA
CAAAGCCCCTAAAGGAGGATTTGGCCTTTCAAACTCTAGGCACTAACGTAACTGTAGGGTCTGCCCACATGTTGAAGTATTGCCAAGAGA
GGACTCAGTGTGAAGCCTTCATCAATAGCAAGCACTTTTTAAGGGAGTAAAAGTTGTTAAAGGCAAACCTCAAAAACATGAAAGGGCATT
CAGGATGTCCCATGGCAATAAGAACAGGGGAAATCTCAGAGCACAATTCAGCAGGATGAGAGAAGGGGAACCAGAAGCTCCGGAGTCATT
GCTCACTTCAGAGTTTGAATTCGTGAGCTGACAAAGAGTAACATGCTCTTTCTACACAGACATGGACAATTTAGACAGTATTGGAAAATT
ACTTGAAGCTGGATTTTCATGAAGTTCTGAATGAGTGTAAATGTTTTTTAGGATACTATAAAGAGTGATGTTTTTCATAAGCACCATAAA
ATGGGTTCTGGAAAAACTGATTACCTTAGCATCCTGTAATATAACTTATGGTAGCAGATTGGGGAAAATGAAGCAGCCCACTGAATAATT
GACAAAGTCTGCTTGGAGAACATTCTAAGGTACAATATCATGGAGCTCCTTTTTCCTTTCTCCACTAATTGCGTGATGAGCTATTGTTCT
GGCTGTTAATTCTCCAACTCGGCTGTCATTTGAAGTGGCAGACTTAATATGGAAAGTTTTTATAATTATGAGTTTGAAAAAGCATTTTAA
GATGATACAGAAAGTATCCAAAACAACAGAAAAAAAAAGCCACGTCATTTTAGATGAATTGCGTGCCTTAAAATGGTGAACGTTAGAAAA
TTAAACAAGTCTGGATTCCACAAGTAGTTCCAAGTCACCAAGTGACAAAAACAAGGTTAACATTAAAAAAGAAAAACAACAACAACGACA
AAAAGCTCCAAGCTGCAGTGGATTTAATTATGAGGCTAAAACTACCTCATACTTTCCTTGGAAGAACTAATTAGCTATGGTTTATTGTAG
GGTTTTGTTTGTTTGTTTTTTAAAGCAAATGATTTCCATATTCCAGATTGATCTTTTTTGTCATCTTTGCTTCAAAATTACATAAAAGGT
GCTCCTTTCCCCCTTCTTTTATACAAGTTTCTTGTTCATATTGTGAATAGAAAAGTTTCTGAACAACTTTTTTGGAACATTTTCTATCTA
TATTCCAAAGCATGTAATATATACATAAAAACGATTTGTTAAACTGGTCCTTAGTCATTTGTATAATTAGAAATGAAGTTTGGGAAAAAA
TTTTGGAAAAAAGACAAGCAAAAAAAAATAACTTATTCCTTTTTTGCATATTTGTATAGCCTTCTAGAATCAGAAATAACCTTTTTGCAT
ATTCTTTTATTGTTCTGACTTTTCAAGACCTATTATTTTTTTACATAGGTCAATAAACAAAAGGTGTGCTACTGAAAATGTTTACGTTTT
CTTCCATTTATGTCAGGGGTTCATGTGAAGCAGGTCGCAGTGCTCTACTTCAAGTAATCATATTGGGCAAGGCTTCGGATTTTTATTTAT
AGTATTACCGTATTTTATTAATTCCGGGATGTACATTTTTAAATATTTACATTAAAAACATGGTTCATCTTTTTATTGATGGCATATTCT

>70400_70400_2_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000295874_FRMD4B_chr3_69225807_ENST00000542259_length(amino acids)=210AA_BP=126
MRFSGGRSAASRIPRGLGPPSAGGPWSGRAGEAPRLSGGSHGGKNLFNKFTSLLSSFRCAFSDMRRLLEPCWWILFLKITSSVLHYVVCF
PALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLD

--------------------------------------------------------------
>70400_70400_3_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000474889_FRMD4B_chr3_69225807_ENST00000398540_length(transcript)=2692nt_BP=567nt
CTCAAGTTGGGGATCCTCGGCTGCTCGCCGCCGCCGCCCGCGGTCCCTGCCTGCCCCAGGCCCGGGGCATCGCCGCCGGCCGCCGACTCC
GCGCCCTGCCCGATCGGCTCTCTCCTTTTTAAACGGAAAGCAGCCTTTCTCCGCCGAGAGGATCGTCCCCAGCGTGGCTCTGCGTTCCCG
GTCACTTTTTGAGATTTTCCGGGGGGCGCTCGGCGGCTTCCCGGATTCCAAGGGGACTCGGGCCGCCGAGCGCGGGGGGCCCGTGGAGCG
GGCGAGCCGGGGAAGCGCCCCGGCTTAGCGGAGGCTCGCACGGAGGCAAGAACTTATTCAACAAGTTTACCTCCCTGCTTTCCTCTTTTC
GATGTGCGTTTTCGGACATGCGGAGGTTACTGGAACCGTGTTGGTGGATTTTGTTCCTGAAAATCACCAGTTCCGTGCTCCATTATGTCG
TGTGCTTCCCCGCGTTGACAGAAGGCTACGTTGGGGCCCTGCACGAGAATAGACACGGCAGCGCAGTGCAGATCCGCAGGCGCAAGGCTT
CAGGCGACCCGTACTGGGCCTACTCTGTGTCTTCTACAAATGCTTCTGGGAACTGGAGGACCCAGTTAACCATAGGGCTGTCGGATTACG
AGACTCCAGCACATTCTTCTTACACCAGCTGCTATGGCAATGTCTATAATCCTTTACCCTCTCCAAGCAGACAATACACAGAAATCAGTC
AACTGGATGGTACAGATGGAAACCAGCTGGAAGACAACCTGGAGAGTAGTGAGCAGAGACTCTTTTGGCATGAAGATTCAAAGCCTGGAA
CATTAGTCTGAACTGCAGTTGGACCTCCTGACCAAGCACTGCGTTCTCACACTAGTGTGCCTTGCAAATTGTATTTGTCTTCCGAGAGGA
TGTTCGTTTTAGAAACCTAAAGACATCAAAGGTTGAAGAGAAGACTTAGTTGCCCTGGAAGTGAATCAGTGAATCACACACCAAGCCCCA
CAAAGCCCCTAAAGGAGGATTTGGCCTTTCAAACTCTAGGCACTAACGTAACTGTAGGGTCTGCCCACATGTTGAAGTATTGCCAAGAGA
GGACTCAGTGTGAAGCCTTCATCAATAGCAAGCACTTTTTAAGGGAGTAAAAGTTGTTAAAGGCAAACCTCAAAAACATGAAAGGGCATT
CAGGATGTCCCATGGCAATAAGAACAGGGGAAATCTCAGAGCACAATTCAGCAGGATGAGAGAAGGGGAACCAGAAGCTCCGGAGTCATT
GCTCACTTCAGAGTTTGAATTCGTGAGCTGACAAAGAGTAACATGCTCTTTCTACACAGACATGGACAATTTAGACAGTATTGGAAAATT
ACTTGAAGCTGGATTTTCATGAAGTTCTGAATGAGTGTAAATGTTTTTTAGGATACTATAAAGAGTGATGTTTTTCATAAGCACCATAAA
ATGGGTTCTGGAAAAACTGATTACCTTAGCATCCTGTAATATAACTTATGGTAGCAGATTGGGGAAAATGAAGCAGCCCACTGAATAATT
GACAAAGTCTGCTTGGAGAACATTCTAAGGTACAATATCATGGAGCTCCTTTTTCCTTTCTCCACTAATTGCGTGATGAGCTATTGTTCT
GGCTGTTAATTCTCCAACTCGGCTGTCATTTGAAGTGGCAGACTTAATATGGAAAGTTTTTATAATTATGAGTTTGAAAAAGCATTTTAA
GATGATACAGAAAGTATCCAAAACAACAGAAAAAAAAAGCCACGTCATTTTAGATGAATTGCGTGCCTTAAAATGGTGAACGTTAGAAAA
TTAAACAAGTCTGGATTCCACAAGTAGTTCCAAGTCACCAAGTGACAAAAACAAGGTTAACATTAAAAAAGAAAAACAACAACAACGACA
AAAAGCTCCAAGCTGCAGTGGATTTAATTATGAGGCTAAAACTACCTCATACTTTCCTTGGAAGAACTAATTAGCTATGGTTTATTGTAG
GGTTTTGTTTGTTTGTTTTTTAAAGCAAATGATTTCCATATTCCAGATTGATCTTTTTTGTCATCTTTGCTTCAAAATTACATAAAAGGT
GCTCCTTTCCCCCTTCTTTTATACAAGTTTCTTGTTCATATTGTGAATAGAAAAGTTTCTGAACAACTTTTTTGGAACATTTTCTATCTA
TATTCCAAAGCATGTAATATATACATAAAAACGATTTGTTAAACTGGTCCTTAGTCATTTGTATAATTAGAAATGAAGTTTGGGAAAAAA
TTTTGGAAAAAAGACAAGCAAAAAAAAATAACTTATTCCTTTTTTGCATATTTGTATAGCCTTCTAGAATCAGAAATAACCTTTTTGCAT
ATTCTTTTATTGTTCTGACTTTTCAAGACCTATTATTTTTTTACATAGGTCAATAAACAAAAGGTGTGCTACTGAAAATGTTTACGTTTT
CTTCCATTTATGTCAGGGGTTCATGTGAAGCAGGTCGCAGTGCTCTACTTCAAGTAATCATATTGGGCAAGGCTTCGGATTTTTATTTAT
AGTATTACCGTATTTTATTAATTCCGGGATGTACATTTTTAAATATTTACATTAAAAACATGGTTCATCTTTTTATTGATGGCATATTCT

>70400_70400_3_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000474889_FRMD4B_chr3_69225807_ENST00000398540_length(amino acids)=210AA_BP=126
MRFSGGRSAASRIPRGLGPPSAGGPWSGRAGEAPRLSGGSHGGKNLFNKFTSLLSSFRCAFSDMRRLLEPCWWILFLKITSSVLHYVVCF
PALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLD

--------------------------------------------------------------
>70400_70400_4_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000474889_FRMD4B_chr3_69225807_ENST00000542259_length(transcript)=2687nt_BP=567nt
CTCAAGTTGGGGATCCTCGGCTGCTCGCCGCCGCCGCCCGCGGTCCCTGCCTGCCCCAGGCCCGGGGCATCGCCGCCGGCCGCCGACTCC
GCGCCCTGCCCGATCGGCTCTCTCCTTTTTAAACGGAAAGCAGCCTTTCTCCGCCGAGAGGATCGTCCCCAGCGTGGCTCTGCGTTCCCG
GTCACTTTTTGAGATTTTCCGGGGGGCGCTCGGCGGCTTCCCGGATTCCAAGGGGACTCGGGCCGCCGAGCGCGGGGGGCCCGTGGAGCG
GGCGAGCCGGGGAAGCGCCCCGGCTTAGCGGAGGCTCGCACGGAGGCAAGAACTTATTCAACAAGTTTACCTCCCTGCTTTCCTCTTTTC
GATGTGCGTTTTCGGACATGCGGAGGTTACTGGAACCGTGTTGGTGGATTTTGTTCCTGAAAATCACCAGTTCCGTGCTCCATTATGTCG
TGTGCTTCCCCGCGTTGACAGAAGGCTACGTTGGGGCCCTGCACGAGAATAGACACGGCAGCGCAGTGCAGATCCGCAGGCGCAAGGCTT
CAGGCGACCCGTACTGGGCCTACTCTGTGTCTTCTACAAATGCTTCTGGGAACTGGAGGACCCAGTTAACCATAGGGCTGTCGGATTACG
AGACTCCAGCACATTCTTCTTACACCAGCTGCTATGGCAATGTCTATAATCCTTTACCCTCTCCAAGCAGACAATACACAGAAATCAGTC
AACTGGATGGTACAGATGGAAACCAGCTGGAAGACAACCTGGAGAGTAGTGAGCAGAGACTCTTTTGGCATGAAGATTCAAAGCCTGGAA
CATTAGTCTGAACTGCAGTTGGACCTCCTGACCAAGCACTGCGTTCTCACACTAGTGTGCCTTGCAAATTGTATTTGTCTTCCGAGAGGA
TGTTCGTTTTAGAAACCTAAAGACATCAAAGGTTGAAGAGAAGACTTAGTTGCCCTGGAAGTGAATCAGTGAATCACACACCAAGCCCCA
CAAAGCCCCTAAAGGAGGATTTGGCCTTTCAAACTCTAGGCACTAACGTAACTGTAGGGTCTGCCCACATGTTGAAGTATTGCCAAGAGA
GGACTCAGTGTGAAGCCTTCATCAATAGCAAGCACTTTTTAAGGGAGTAAAAGTTGTTAAAGGCAAACCTCAAAAACATGAAAGGGCATT
CAGGATGTCCCATGGCAATAAGAACAGGGGAAATCTCAGAGCACAATTCAGCAGGATGAGAGAAGGGGAACCAGAAGCTCCGGAGTCATT
GCTCACTTCAGAGTTTGAATTCGTGAGCTGACAAAGAGTAACATGCTCTTTCTACACAGACATGGACAATTTAGACAGTATTGGAAAATT
ACTTGAAGCTGGATTTTCATGAAGTTCTGAATGAGTGTAAATGTTTTTTAGGATACTATAAAGAGTGATGTTTTTCATAAGCACCATAAA
ATGGGTTCTGGAAAAACTGATTACCTTAGCATCCTGTAATATAACTTATGGTAGCAGATTGGGGAAAATGAAGCAGCCCACTGAATAATT
GACAAAGTCTGCTTGGAGAACATTCTAAGGTACAATATCATGGAGCTCCTTTTTCCTTTCTCCACTAATTGCGTGATGAGCTATTGTTCT
GGCTGTTAATTCTCCAACTCGGCTGTCATTTGAAGTGGCAGACTTAATATGGAAAGTTTTTATAATTATGAGTTTGAAAAAGCATTTTAA
GATGATACAGAAAGTATCCAAAACAACAGAAAAAAAAAGCCACGTCATTTTAGATGAATTGCGTGCCTTAAAATGGTGAACGTTAGAAAA
TTAAACAAGTCTGGATTCCACAAGTAGTTCCAAGTCACCAAGTGACAAAAACAAGGTTAACATTAAAAAAGAAAAACAACAACAACGACA
AAAAGCTCCAAGCTGCAGTGGATTTAATTATGAGGCTAAAACTACCTCATACTTTCCTTGGAAGAACTAATTAGCTATGGTTTATTGTAG
GGTTTTGTTTGTTTGTTTTTTAAAGCAAATGATTTCCATATTCCAGATTGATCTTTTTTGTCATCTTTGCTTCAAAATTACATAAAAGGT
GCTCCTTTCCCCCTTCTTTTATACAAGTTTCTTGTTCATATTGTGAATAGAAAAGTTTCTGAACAACTTTTTTGGAACATTTTCTATCTA
TATTCCAAAGCATGTAATATATACATAAAAACGATTTGTTAAACTGGTCCTTAGTCATTTGTATAATTAGAAATGAAGTTTGGGAAAAAA
TTTTGGAAAAAAGACAAGCAAAAAAAAATAACTTATTCCTTTTTTGCATATTTGTATAGCCTTCTAGAATCAGAAATAACCTTTTTGCAT
ATTCTTTTATTGTTCTGACTTTTCAAGACCTATTATTTTTTTACATAGGTCAATAAACAAAAGGTGTGCTACTGAAAATGTTTACGTTTT
CTTCCATTTATGTCAGGGGTTCATGTGAAGCAGGTCGCAGTGCTCTACTTCAAGTAATCATATTGGGCAAGGCTTCGGATTTTTATTTAT
AGTATTACCGTATTTTATTAATTCCGGGATGTACATTTTTAAATATTTACATTAAAAACATGGTTCATCTTTTTATTGATGGCATATTCT

>70400_70400_4_PTPRG-FRMD4B_PTPRG_chr3_61734656_ENST00000474889_FRMD4B_chr3_69225807_ENST00000542259_length(amino acids)=210AA_BP=126
MRFSGGRSAASRIPRGLGPPSAGGPWSGRAGEAPRLSGGSHGGKNLFNKFTSLLSSFRCAFSDMRRLLEPCWWILFLKITSSVLHYVVCF
PALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTPRG-FRMD4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRG-FRMD4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRG-FRMD4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource