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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRG-SH3RF1 (FusionGDB2 ID:70410)

Fusion Gene Summary for PTPRG-SH3RF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG-SH3RF1
Fusion gene ID: 70410
HgeneTgene
Gene symbol

PTPRG

SH3RF1

Gene ID

5793

57630

Gene nameprotein tyrosine phosphatase receptor type GSH3 domain containing ring finger 1
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPGPOSH|RNF142|SH3MD2
Cytomap

3p14.2

4q32.3-q33

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tE3 ubiquitin-protein ligase SH3RF1RING-type E3 ubiquitin transferase SH3RF1SH3 domain-containing RING finger protein 1SH3 multiple domains 2SH3 multiple domains protein 2plenty of SH3 domainsplenty of SH3sputative E3 ubiquitin-protein ligase SH3RF1
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000295874, ENST00000474889, 
ENST00000495879, 		ENST00000508685, 
ENST00000284637, 
Fusion gene scores* DoF score18 X 14 X 10=25202 X 2 X 2=8
# samples 222
** MAII scorelog2(22/2520*10)=-3.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PTPRG [Title/Abstract] AND SH3RF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRG(61989171)-SH3RF1(170077830), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PTPRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SH3RF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5734-11APTPRGchr3

61989171

+SH3RF1chr4

170077830

-


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Fusion Gene ORF analysis for PTPRG-SH3RF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000295874ENST00000508685PTPRGchr3

61989171

+SH3RF1chr4

170077830

-
5CDS-5UTRENST00000474889ENST00000508685PTPRGchr3

61989171

+SH3RF1chr4

170077830

-
In-frameENST00000295874ENST00000284637PTPRGchr3

61989171

+SH3RF1chr4

170077830

-
In-frameENST00000474889ENST00000284637PTPRGchr3

61989171

+SH3RF1chr4

170077830

-
intron-3CDSENST00000495879ENST00000284637PTPRGchr3

61989171

+SH3RF1chr4

170077830

-
intron-5UTRENST00000495879ENST00000508685PTPRGchr3

61989171

+SH3RF1chr4

170077830

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295874PTPRGchr361989171+ENST00000284637SH3RF1chr4170077830-54338961883169993
ENST00000474889PTPRGchr361989171+ENST00000284637SH3RF1chr4170077830-54338961883169993

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295874ENST00000284637PTPRGchr361989171+SH3RF1chr4170077830-0.0002796720.9997203
ENST00000474889ENST00000284637PTPRGchr361989171+SH3RF1chr4170077830-0.0002796720.9997203

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Fusion Genomic Features for PTPRG-SH3RF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRG-SH3RF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:61989171/chr4:170077830)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112397_403131889.0Compositional biasNote=Poly-Pro
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112417_424131889.0Compositional biasNote=Poly-Ala
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112657_662131889.0Compositional biasNote=Poly-Ala
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112134_193131889.0DomainSH3 1
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112196_259131889.0DomainSH3 2
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112445_506131889.0DomainSH3 3
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112829_888131889.0DomainSH3 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+4291150_14101731417.0DomainTyrosine-protein phosphatase 2
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+429349_4481731417.0DomainFibronectin type-III
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+42958_3211731417.0DomainAlpha-carbonic anhydrase
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+429848_11191731417.0DomainTyrosine-protein phosphatase 1
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+4301150_14101731446.0DomainTyrosine-protein phosphatase 2
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+430349_4481731446.0DomainFibronectin type-III
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+43058_3211731446.0DomainAlpha-carbonic anhydrase
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+430848_11191731446.0DomainTyrosine-protein phosphatase 1
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+4291060_10661731417.0RegionSubstrate binding
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+4301060_10661731446.0RegionSubstrate binding
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+42920_7361731417.0Topological domainExtracellular
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+429763_14451731417.0Topological domainCytoplasmic
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+43020_7361731446.0Topological domainExtracellular
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+430763_14451731446.0Topological domainCytoplasmic
HgenePTPRGchr3:61989171chr4:170077830ENST00000295874+429737_7621731417.0TransmembraneHelical
HgenePTPRGchr3:61989171chr4:170077830ENST00000474889+430737_7621731446.0TransmembraneHelical
TgeneSH3RF1chr3:61989171chr4:170077830ENST0000028463711212_53131889.0Zinc fingerRING-type


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Fusion Gene Sequence for PTPRG-SH3RF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70410_70410_1_PTPRG-SH3RF1_PTPRG_chr3_61989171_ENST00000295874_SH3RF1_chr4_170077830_ENST00000284637_length(transcript)=5433nt_BP=896nt
CTCAAGTTGGGGATCCTCGGCTGCTCGCCGCCGCCGCCCGCGGTCCCTGCCTGCCCCAGGCCCGGGGCATCGCCGCCGGCCGCCGACTCC
GCGCCCTGCCCGATCGGCTCTCTCCTTTTTAAACGGAAAGCAGCCTTTCTCCGCCGAGAGGATCGTCCCCAGCGTGGCTCTGCGTTCCCG
GTCACTTTTTGAGATTTTCCGGGGGGCGCTCGGCGGCTTCCCGGATTCCAAGGGGACTCGGGCCGCCGAGCGCGGGGGGCCCGTGGAGCG
GGCGAGCCGGGGAAGCGCCCCGGCTTAGCGGAGGCTCGCACGGAGGCAAGAACTTATTCAACAAGTTTACCTCCCTGCTTTCCTCTTTTC
GATGTGCGTTTTCGGACATGCGGAGGTTACTGGAACCGTGTTGGTGGATTTTGTTCCTGAAAATCACCAGTTCCGTGCTCCATTATGTCG
TGTGCTTCCCCGCGTTGACAGAAGGCTACGTTGGGGCCCTGCACGAGAATAGACACGGCAGCGCAGTGCAGATCCGCAGGCGCAAGGCTT
CAGGCGACCCGTACTGGGCCTACTCTGGTGCCTATGGTCCTGAGCACTGGGTCACGTCTAGTGTCAGCTGTGGGGGCCGTCACCAGTCTC
CTATTGACATTTTAGACCAGTATGCGCGTGTTGGGGAAGAATACCAGGAACTGCAACTCGATGGCTTCGACAATGAGTCTTCTAACAAAA
CCTGGATGAAAAACACAGGGAAAACAGTCGCCATCCTTCTGAAAGACGACTATTTTGTCAGTGGAGCTGGTCTACCTGGCAGATTCAAAG
CTGAGAAGGTGGAATTTCACTGGGGCCACAGCAATGGCTCAGCGGGCTCTGAACACAGCATCAATGGCAGGAGGTTTCCTGTTGAGGGTA
TACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGCAAAGGTGACATCATCATTT
TGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAAC
CGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAA
AGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATAGGAATATTTCCAATTTCAT
ATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAG
CAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACA
AGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGA
TCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCC
CAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCC
CTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAG
GATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATACACTCCTCGGAAAGAGGATG
AACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGA
TAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCC
AGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCA
GTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAG
TCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACACCCATCCAGGTACAGAATG
CCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGC
ACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTT
CTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACA
GTTCAGCAACCAAACCAGACAAGGATAGCAAAAAAGAAAAAAAGGGTTTGTTGAAGTTGCTTTCTGGCGCCTCCACTAAACGGAAGCCCC
GCGTGTCTCCTCCAGCATCGCCCACCCTAGAAGTGGAGCTGGGCAGTGCAGAGCTTCCTCTCCAGGGAGCGGTGGGGCCCGAACTGCCAC
CAGGAGGTGGCCATGGCAGGGCAGGCTCCTGCCCTGTGGACGGGGACGGACCGGTCACGACTGCAGTGGCAGGAGCAGCCCTGGCCCAGG
ATGCTTTTCATAGGAAGGCAAGTTCCCTGGACTCCGCAGTTCCCATCGCTCCACCTCCTCGCCAGGCCTGTTCCTCCCTGGGTCCTGTCT
TGAATGAGTCTAGACCTGTCGTTTGTGAAAGGCACAGGGTGGTGGTTTCCTATCCTCCTCAGAGTGAGGCAGAACTTGAACTTAAAGAAG
GAGATATTGTGTTTGTTCATAAAAAACGAGAGGATGGCTGGTTCAAAGGCACATTACAACGTAATGGGAAAACTGGCCTTTTCCCAGGAA
GCTTTGTGGAAAACATATGAGGAGACTGACACTGAAGAAGCTTAAAATCACTTCACACAACAAAGTAGCACAAAGCAGTTTAACAGAAAG
AGCACATTTGTGGACTTCCAGATGGTCAGGAGATGAGCAAAGGATTGGTATGTGACTCTGATGCCCCAGCACAGTTACCCCAGCGAGCAG
AATGAAGAAGATGTTTGTGTGGGTTTTGTTAGTCTGGATTCGGATGTATAAGGTGTGCCTTGTACTGTCTGATTTACTACACAGAGAAAC
TTTTTTTTTTTTTTAAGATATATGACTAAAATGGACAATTGTTTACAAGGCTTAACTAATTTATTTGCTTTTTTAAACTTGAACTTTTCG
TATAATAGATACGTTCTTTGGATTATGATTTTAAGAAATTATTAATTTATGAAATGATAGGTAAGGAGAAGCTGGATTATCTCCTGTTGA
GAGCAAGAGATTCGTTTTGACATAGAGTGAATGCATTTTCCCCTCTCCTCCTCCCTGCTACCATTATATTTTGGGGTTATGTTTTGCTTC
TTTAAGATAGAAATCCCAGTTCTCTAATTTGGTTTTCTTCTTTGGGAAACCAAACATACAAATGAATCAGTATCAATTAGGGCCTGGGGT
AGAGAGACAGAAACTTGAGAGAAGAGAAGTTAGTGATTCCCTCTCTTTCTAGTTTGGTAGGAATCACCCTGAAGACCTAGTCCTCAATTT
AATTGTGTGGGTTTTTAATTTTCCTAGAATGAAGTGACTGAAACAATGAGAAAGAATACAGCACAACCCTTGAACAAAATGTATTTAGAA
ATATATTTAGTTTTATAGCAGAAGCAGCTCAATTGTTTGGTTGGAAAGTAGGGGAAATTGAAGTTGTAGTCACTGTCTGAGAATGGCTAT
GAAGCGTCATTTCACATTTTACCCCAACTGACCTGCATGCCCAGGACACAAGTAAAACATTTGTGAGATAGTGGTGGTAAGTGATGCACT
CGTGTTAAGTCAAAGGCTATAAGAAACACTGTGAAAAGTTCATATTCATCCATTGTGATTCTTTCCCCACGTCTTGCATGTATTACTGGA
TTCCCACAGTAATATAGACTGTGCATGGTGTGTATATTTCATTGCGATTTCCTGTTAAGATGAGTTTGTACTCAGAATTGACCAATTCAG
GAGGTGTAAAAATAAACAGTGTTCTCTTCTCTACCCCAAAGCCACTACTGACCAAGGTCTCTTCAGTGCACTCGCTCCCTCTCTGGCTAA
GGCATGCATTAGCCACTACACAAGTCATTAGTGAAAGTGGTCTTTTATGTCCTCCCAGCAGACAGACATCAAGGATGAGTTAACCAGGAG
ACTACTCCTGTGACTGTGGAGCTCTGGAAGGCTTGGTGGGAGTGAATTTGCCCACACCTTACAATTGTGGCAGGATCCAGAAGAGCCTGT
CTTTTTATATCCATTCCTTGATGTCATTGGCCTCTCCCACCGATTTCATTACGGTGCCACGCAGTCATGGATCTGGGTAGTCCGGAAAAC
AAAAGGAGGGAAGACAGCCTGGTAATGAATAAGATCCTTACCACAGTTTTCTCATGGGAAATACATAATAAACCCTTTCATCTTTTTTTT
TTTCCTTTAAGAATTAAAACTGGGAAATAGAAACATGAACTGAAAAGTCTTGCAATGACAAGAGGTTTCATGGTCTTAAAAAGATACTTT
ATGTGGTTGAAGATGAAATCATTCCTAAATTAACCTTTTTTTTAAAAAAAAACAATGTATATTATGTTCCTGTGTGTTGAATTTAAAAAA
AAAATACTTTACTTGGATATTCATGTAATATATAAAGGTTTGGTGAAATGAACTTTAGTTAGGAAAAAGCTGGCATCAGCTTTCATCTGT
GTAAGTTGACACCAATGTGTCATAATATTCTTTATTTTGGGAAATTAGTGTATTTTATAAAAATTTTAAAAAGAAAAAAGACTACTACAG
GTTAAGATAATTTTTTTACCTGTCTTTTCTCCATATTTTAAGCTATGTGATTGAAGTACCTCTGTTCATAGTTTCCTGGTATAAAGTTGG
TTAAAATTTCATCTGTTAATAGATCATTAGGTAATATAATGTATGGGTTTTCTATTGGTTTTTTGCAGACAGTAGAGGGAGATTTTGTAA
CAAGGGCTTGTTACACAGTGATATGGTAATGATAAAATTGCGATTTATCACTCCTTTTCATGTTAATAATTTGAGGACTGGATAAAAGGT

>70410_70410_1_PTPRG-SH3RF1_PTPRG_chr3_61989171_ENST00000295874_SH3RF1_chr4_170077830_ENST00000284637_length(amino acids)=993AA_BP=236
MRFSGGRSAASRIPRGLGPPSAGGPWSGRAGEAPRLSGGSHGGKNLFNKFTSLLSSFRCAFSDMRRLLEPCWWILFLKITSSVLHYVVCF
PALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWM
KNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRR
QVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVE
FNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISE
LSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGST
DQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTS
RGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAG
LSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSA
TKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAF
HRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFV

--------------------------------------------------------------
>70410_70410_2_PTPRG-SH3RF1_PTPRG_chr3_61989171_ENST00000474889_SH3RF1_chr4_170077830_ENST00000284637_length(transcript)=5433nt_BP=896nt
CTCAAGTTGGGGATCCTCGGCTGCTCGCCGCCGCCGCCCGCGGTCCCTGCCTGCCCCAGGCCCGGGGCATCGCCGCCGGCCGCCGACTCC
GCGCCCTGCCCGATCGGCTCTCTCCTTTTTAAACGGAAAGCAGCCTTTCTCCGCCGAGAGGATCGTCCCCAGCGTGGCTCTGCGTTCCCG
GTCACTTTTTGAGATTTTCCGGGGGGCGCTCGGCGGCTTCCCGGATTCCAAGGGGACTCGGGCCGCCGAGCGCGGGGGGCCCGTGGAGCG
GGCGAGCCGGGGAAGCGCCCCGGCTTAGCGGAGGCTCGCACGGAGGCAAGAACTTATTCAACAAGTTTACCTCCCTGCTTTCCTCTTTTC
GATGTGCGTTTTCGGACATGCGGAGGTTACTGGAACCGTGTTGGTGGATTTTGTTCCTGAAAATCACCAGTTCCGTGCTCCATTATGTCG
TGTGCTTCCCCGCGTTGACAGAAGGCTACGTTGGGGCCCTGCACGAGAATAGACACGGCAGCGCAGTGCAGATCCGCAGGCGCAAGGCTT
CAGGCGACCCGTACTGGGCCTACTCTGGTGCCTATGGTCCTGAGCACTGGGTCACGTCTAGTGTCAGCTGTGGGGGCCGTCACCAGTCTC
CTATTGACATTTTAGACCAGTATGCGCGTGTTGGGGAAGAATACCAGGAACTGCAACTCGATGGCTTCGACAATGAGTCTTCTAACAAAA
CCTGGATGAAAAACACAGGGAAAACAGTCGCCATCCTTCTGAAAGACGACTATTTTGTCAGTGGAGCTGGTCTACCTGGCAGATTCAAAG
CTGAGAAGGTGGAATTTCACTGGGGCCACAGCAATGGCTCAGCGGGCTCTGAACACAGCATCAATGGCAGGAGGTTTCCTGTTGAGGGTA
TACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGCAAAGGTGACATCATCATTT
TGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAAC
CGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAA
AGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATAGGAATATTTCCAATTTCAT
ATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAG
CAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACA
AGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGA
TCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCC
CAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCC
CTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAG
GATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATACACTCCTCGGAAAGAGGATG
AACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGA
TAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCC
AGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCA
GTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAG
TCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACACCCATCCAGGTACAGAATG
CCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGC
ACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTT
CTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACA
GTTCAGCAACCAAACCAGACAAGGATAGCAAAAAAGAAAAAAAGGGTTTGTTGAAGTTGCTTTCTGGCGCCTCCACTAAACGGAAGCCCC
GCGTGTCTCCTCCAGCATCGCCCACCCTAGAAGTGGAGCTGGGCAGTGCAGAGCTTCCTCTCCAGGGAGCGGTGGGGCCCGAACTGCCAC
CAGGAGGTGGCCATGGCAGGGCAGGCTCCTGCCCTGTGGACGGGGACGGACCGGTCACGACTGCAGTGGCAGGAGCAGCCCTGGCCCAGG
ATGCTTTTCATAGGAAGGCAAGTTCCCTGGACTCCGCAGTTCCCATCGCTCCACCTCCTCGCCAGGCCTGTTCCTCCCTGGGTCCTGTCT
TGAATGAGTCTAGACCTGTCGTTTGTGAAAGGCACAGGGTGGTGGTTTCCTATCCTCCTCAGAGTGAGGCAGAACTTGAACTTAAAGAAG
GAGATATTGTGTTTGTTCATAAAAAACGAGAGGATGGCTGGTTCAAAGGCACATTACAACGTAATGGGAAAACTGGCCTTTTCCCAGGAA
GCTTTGTGGAAAACATATGAGGAGACTGACACTGAAGAAGCTTAAAATCACTTCACACAACAAAGTAGCACAAAGCAGTTTAACAGAAAG
AGCACATTTGTGGACTTCCAGATGGTCAGGAGATGAGCAAAGGATTGGTATGTGACTCTGATGCCCCAGCACAGTTACCCCAGCGAGCAG
AATGAAGAAGATGTTTGTGTGGGTTTTGTTAGTCTGGATTCGGATGTATAAGGTGTGCCTTGTACTGTCTGATTTACTACACAGAGAAAC
TTTTTTTTTTTTTTAAGATATATGACTAAAATGGACAATTGTTTACAAGGCTTAACTAATTTATTTGCTTTTTTAAACTTGAACTTTTCG
TATAATAGATACGTTCTTTGGATTATGATTTTAAGAAATTATTAATTTATGAAATGATAGGTAAGGAGAAGCTGGATTATCTCCTGTTGA
GAGCAAGAGATTCGTTTTGACATAGAGTGAATGCATTTTCCCCTCTCCTCCTCCCTGCTACCATTATATTTTGGGGTTATGTTTTGCTTC
TTTAAGATAGAAATCCCAGTTCTCTAATTTGGTTTTCTTCTTTGGGAAACCAAACATACAAATGAATCAGTATCAATTAGGGCCTGGGGT
AGAGAGACAGAAACTTGAGAGAAGAGAAGTTAGTGATTCCCTCTCTTTCTAGTTTGGTAGGAATCACCCTGAAGACCTAGTCCTCAATTT
AATTGTGTGGGTTTTTAATTTTCCTAGAATGAAGTGACTGAAACAATGAGAAAGAATACAGCACAACCCTTGAACAAAATGTATTTAGAA
ATATATTTAGTTTTATAGCAGAAGCAGCTCAATTGTTTGGTTGGAAAGTAGGGGAAATTGAAGTTGTAGTCACTGTCTGAGAATGGCTAT
GAAGCGTCATTTCACATTTTACCCCAACTGACCTGCATGCCCAGGACACAAGTAAAACATTTGTGAGATAGTGGTGGTAAGTGATGCACT
CGTGTTAAGTCAAAGGCTATAAGAAACACTGTGAAAAGTTCATATTCATCCATTGTGATTCTTTCCCCACGTCTTGCATGTATTACTGGA
TTCCCACAGTAATATAGACTGTGCATGGTGTGTATATTTCATTGCGATTTCCTGTTAAGATGAGTTTGTACTCAGAATTGACCAATTCAG
GAGGTGTAAAAATAAACAGTGTTCTCTTCTCTACCCCAAAGCCACTACTGACCAAGGTCTCTTCAGTGCACTCGCTCCCTCTCTGGCTAA
GGCATGCATTAGCCACTACACAAGTCATTAGTGAAAGTGGTCTTTTATGTCCTCCCAGCAGACAGACATCAAGGATGAGTTAACCAGGAG
ACTACTCCTGTGACTGTGGAGCTCTGGAAGGCTTGGTGGGAGTGAATTTGCCCACACCTTACAATTGTGGCAGGATCCAGAAGAGCCTGT
CTTTTTATATCCATTCCTTGATGTCATTGGCCTCTCCCACCGATTTCATTACGGTGCCACGCAGTCATGGATCTGGGTAGTCCGGAAAAC
AAAAGGAGGGAAGACAGCCTGGTAATGAATAAGATCCTTACCACAGTTTTCTCATGGGAAATACATAATAAACCCTTTCATCTTTTTTTT
TTTCCTTTAAGAATTAAAACTGGGAAATAGAAACATGAACTGAAAAGTCTTGCAATGACAAGAGGTTTCATGGTCTTAAAAAGATACTTT
ATGTGGTTGAAGATGAAATCATTCCTAAATTAACCTTTTTTTTAAAAAAAAACAATGTATATTATGTTCCTGTGTGTTGAATTTAAAAAA
AAAATACTTTACTTGGATATTCATGTAATATATAAAGGTTTGGTGAAATGAACTTTAGTTAGGAAAAAGCTGGCATCAGCTTTCATCTGT
GTAAGTTGACACCAATGTGTCATAATATTCTTTATTTTGGGAAATTAGTGTATTTTATAAAAATTTTAAAAAGAAAAAAGACTACTACAG
GTTAAGATAATTTTTTTACCTGTCTTTTCTCCATATTTTAAGCTATGTGATTGAAGTACCTCTGTTCATAGTTTCCTGGTATAAAGTTGG
TTAAAATTTCATCTGTTAATAGATCATTAGGTAATATAATGTATGGGTTTTCTATTGGTTTTTTGCAGACAGTAGAGGGAGATTTTGTAA
CAAGGGCTTGTTACACAGTGATATGGTAATGATAAAATTGCGATTTATCACTCCTTTTCATGTTAATAATTTGAGGACTGGATAAAAGGT

>70410_70410_2_PTPRG-SH3RF1_PTPRG_chr3_61989171_ENST00000474889_SH3RF1_chr4_170077830_ENST00000284637_length(amino acids)=993AA_BP=236
MRFSGGRSAASRIPRGLGPPSAGGPWSGRAGEAPRLSGGSHGGKNLFNKFTSLLSSFRCAFSDMRRLLEPCWWILFLKITSSVLHYVVCF
PALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWM
KNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRR
QVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVE
FNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISE
LSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGST
DQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTS
RGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAG
LSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSA
TKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAF
HRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFV

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Fusion Gene PPI Analysis for PTPRG-SH3RF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112440_543131.0889.0AKT2
TgeneSH3RF1chr3:61989171chr4:170077830ENST00000284637112292_362131.0889.0RAC1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRG-SH3RF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRG-SH3RF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource