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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PTPRM-RAB12 (FusionGDB2 ID:70480) |
Fusion Gene Summary for PTPRM-RAB12 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PTPRM-RAB12 | Fusion gene ID: 70480 | Hgene | Tgene | Gene symbol | PTPRM | RAB12 | Gene ID | 5797 | 201475 |
Gene name | protein tyrosine phosphatase receptor type M | RAB12, member RAS oncogene family | |
Synonyms | PTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu | - | |
Cytomap | 18p11.23 | 18p11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor-type tyrosine-protein phosphatase muprotein tyrosine phosphatase muprotein tyrosine phosphatase, receptor type, mu polypeptide | ras-related protein Rab-12putative Ras-related protein Rab-12 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000332175, ENST00000400053, ENST00000400060, ENST00000444013, ENST00000580170, ENST00000578571, | ENST00000329286, | |
Fusion gene scores | * DoF score | 11 X 10 X 6=660 | 8 X 5 X 7=280 |
# samples | 11 | 8 | |
** MAII score | log2(11/660*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPRM [Title/Abstract] AND RAB12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PTPRM(7955412)-RAB12(8624936), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPRM | GO:0006470 | protein dephosphorylation | 8393854|10809770 |
Hgene | PTPRM | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 8393854 |
Hgene | PTPRM | GO:0007165 | signal transduction | 15080886 |
Hgene | PTPRM | GO:0031175 | neuron projection development | 16380380 |
Hgene | PTPRM | GO:0031290 | retinal ganglion cell axon guidance | 15080886 |
Hgene | PTPRM | GO:0042493 | response to drug | 18566238 |
Fusion gene breakpoints across PTPRM (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across RAB12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-D1-A3JQ-01A | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
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Fusion Gene ORF analysis for PTPRM-RAB12 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000332175 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
In-frame | ENST00000400053 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
In-frame | ENST00000400060 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
In-frame | ENST00000444013 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
In-frame | ENST00000580170 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
intron-3CDS | ENST00000578571 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000580170 | PTPRM | chr18 | 7955412 | + | ENST00000329286 | RAB12 | chr18 | 8624936 | + | 3797 | 2169 | 605 | 2677 | 690 |
ENST00000332175 | PTPRM | chr18 | 7955412 | + | ENST00000329286 | RAB12 | chr18 | 8624936 | + | 3797 | 2169 | 605 | 2677 | 690 |
ENST00000400060 | PTPRM | chr18 | 7955412 | + | ENST00000329286 | RAB12 | chr18 | 8624936 | + | 2760 | 1132 | 0 | 1640 | 546 |
ENST00000400053 | PTPRM | chr18 | 7955412 | + | ENST00000329286 | RAB12 | chr18 | 8624936 | + | 2999 | 1371 | 281 | 1879 | 532 |
ENST00000444013 | PTPRM | chr18 | 7955412 | + | ENST00000329286 | RAB12 | chr18 | 8624936 | + | 2121 | 493 | 0 | 1001 | 333 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000580170 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + | 0.000357575 | 0.9996424 |
ENST00000332175 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + | 0.000357575 | 0.9996424 |
ENST00000400060 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + | 9.07E-05 | 0.9999093 |
ENST00000400053 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + | 0.000319835 | 0.99968016 |
ENST00000444013 | ENST00000329286 | PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624936 | + | 0.000113975 | 0.99988604 |
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Fusion Genomic Features for PTPRM-RAB12 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624935 | + | 0.000234864 | 0.9997651 |
PTPRM | chr18 | 7955412 | + | RAB12 | chr18 | 8624935 | + | 0.000234864 | 0.9997651 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PTPRM-RAB12 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:7955412/chr18:8624936) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 186_277 | 377 | 1453.0 | Domain | Note=Ig-like C2-type |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 22_184 | 377 | 1453.0 | Domain | MAM |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 284_379 | 377 | 1453.0 | Domain | Fibronectin type-III 1 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 186_277 | 377 | 1466.0 | Domain | Note=Ig-like C2-type |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 22_184 | 377 | 1466.0 | Domain | MAM |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 284_379 | 377 | 1466.0 | Domain | Fibronectin type-III 1 |
Tgene | RAB12 | chr18:7955412 | chr18:8624936 | ENST00000329286 | 0 | 6 | 155_159 | 75 | 245.0 | Nucleotide binding | Note=GTP | |
Tgene | RAB12 | chr18:7955412 | chr18:8624936 | ENST00000329286 | 0 | 6 | 187_188 | 75 | 245.0 | Nucleotide binding | Note=GTP | |
Tgene | RAB12 | chr18:7955412 | chr18:8624936 | ENST00000329286 | 0 | 6 | 97_101 | 75 | 245.0 | Nucleotide binding | GTP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 1186_1448 | 377 | 1453.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 382_480 | 377 | 1453.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 482_587 | 377 | 1453.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 589_671 | 377 | 1453.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 900_1154 | 377 | 1453.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 1186_1448 | 377 | 1466.0 | Domain | Tyrosine-protein phosphatase 2 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 382_480 | 377 | 1466.0 | Domain | Fibronectin type-III 2 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 482_587 | 377 | 1466.0 | Domain | Fibronectin type-III 3 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 589_671 | 377 | 1466.0 | Domain | Fibronectin type-III 4 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 900_1154 | 377 | 1466.0 | Domain | Tyrosine-protein phosphatase 1 |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 1095_1101 | 377 | 1453.0 | Region | Substrate binding |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 1095_1101 | 377 | 1466.0 | Region | Substrate binding |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 21_742 | 377 | 1453.0 | Topological domain | Extracellular |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 765_1452 | 377 | 1453.0 | Topological domain | Cytoplasmic |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 21_742 | 377 | 1466.0 | Topological domain | Extracellular |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 765_1452 | 377 | 1466.0 | Topological domain | Cytoplasmic |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000332175 | + | 7 | 31 | 743_764 | 377 | 1453.0 | Transmembrane | Helical |
Hgene | PTPRM | chr18:7955412 | chr18:8624936 | ENST00000580170 | + | 7 | 33 | 743_764 | 377 | 1466.0 | Transmembrane | Helical |
Tgene | RAB12 | chr18:7955412 | chr18:8624936 | ENST00000329286 | 0 | 6 | 71_79 | 75 | 245.0 | Motif | Effector region | |
Tgene | RAB12 | chr18:7955412 | chr18:8624936 | ENST00000329286 | 0 | 6 | 49_57 | 75 | 245.0 | Nucleotide binding | Note=GTP |
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Fusion Gene Sequence for PTPRM-RAB12 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>70480_70480_1_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000332175_RAB12_chr18_8624936_ENST00000329286_length(transcript)=3797nt_BP=2169nt GCGGCGTAGAGAAGCTCGCAGCCCTCCGGAGCCTCAGCGATCTCCTGGCTCGCTTTTCCCGCAGCCGCCGAGCAGCGCAGGCCCGGCGAC TCCGGGTGCAGCTGGCCCTGTGCGGTGACATCGCCGTCCGGCGCCAGGCTCGAAGCCGCCTGGCCGCGCCCGCGGGGTCGCAGGCCGCTG GTCCCGCCCGGCCGCGCTCACAAACTACTCGCGGCTCGTGACCCGGGACAAACTTCTGGCGGCGGCGCAGCCTCTTCCACAGTCACCCTC CCCAGAGCCAGCTACCAAAATAGAAGACGCGGCCGGGGCGAGGAGGTGGGCGGGGGGAGCCCGGTGGCCGCTCCTCCCCGCGCGGCTGAC GCCCGCTTCGGCGGCGGTAGTGGCTGTGGCCGCGGGGCCGCCCCCAGCCGAGCTCCCGGAGGCGCTCGGGCGCGGGCCGGCGGGGCACGG GCGCTCACGCCCTCTAGCGGGCCGCGGCGGCGCCGGGCGGCCGTGACGTGAGCGCTCCCTTCAGCCGGCCTGCGGGGCACCGCCAGTCAG TCGGGGAGCAAGAGCCCCGCGCGCAGCCGGCGCGGGCTCGGTCATCGGCGCGCCGCCGCCCGGGGCTGGGCTTGGGGCTGCCTGTGGAGA GGCGGCGGGCGGAACGCGCGCGGCCACGGCCACGGCCACCGCCACGGCCACGGCCGGCAGCTCGGGTCCCGGGTCCCGGGCAGGGGAAGG GGAGAGGCGGCGAGCTCAGCAACCGGAACCGAGGGAAGATTTTGGCTCCGCGGGCTCGCCCTCCGCTCCCTCTGCCAGCGGCGCCAGACG CCGAGTGGGGCCAGGGACAGGGGAGGAGGACCCAGGACCCTGTGCCCGCGCCCCTGGAGCCGCTGGAGTTCGGACTTCTGCAACTGTTGG CACTTTGGGGGCTTGGCTTAGCGCTCTGCTGTTTACCCGTCTCTCCTCGCTGCCTCGGAACCAAAGCTCCCGGCCCCCTCCGCCCTCGCG CGCCCACCCACCGCCGCCGGGGAGCGGCCCGGCCCGCACTCAGCACCATGAGGGGACTTGGGACTTGCCTGGCGACTTTGGCCGGACTTT TGCTAACTGCGGCGGGCGAGACGTTCTCAGGTGGCTGCCTCTTTGATGAGCCGTATAGCACATGTGGATATAGTCAATCTGAAGGTGATG ACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGATCCATGGATGCCATCAGGTTCTTTCATGCTGGTGAATGCCTCTG GGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCA GCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAG ACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTG GACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGG AAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATG TGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATG CTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTA TTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGG CCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACC CAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAA AGTGTGCTGGTGTTGACTTCAAAATCAAAACTGTAGAGCTAAGAGGAAAGAAAATTAGATTACAGATCTGGGACACAGCAGGTCAGGAGA GATTCAACAGCATTACCTCAGCTTATTACAGAAGTGCCAAGGGGATCATATTAGTATATGATATCACTAAGAAGGAGACATTTGATGATT TGCCGAAATGGATGAAGATGATTGATAAGTATGCTTCAGAAGATGCAGAGCTTCTCTTAGTTGGAAATAAGTTGGACTGTGAAACGGACA GAGAAATCACCAGGCAGCAGGGGGAAAAGTTTGCACAGCAGATCACTGGGATGCGGTTCTGTGAAGCAAGTGCCAAGGATAACTTCAATG TGGACGAGATATTTTTGAAACTTGTCGATGACATTCTGAAAAAGATGCCTCTGGATATTTTAAGGAATGAGTTGTCCAATAGTATCCTGT CGTTACAACCAGAGCCTGAGATACCGCCAGAACTGCCTCCACCAAGACCACATGTCCGATGCTGTTGATTTCCTACTTTGGAGACAAAGT GGAAATGATTCCTGGAAAGGGGAAAAAACGTTCTATTCTGCACTACAATCATTTTGACAATTTCCTTTCGCACTTTGTAATCCAAGTCAG AGCTATACACTAACTTGTAAATATGCATATATGCAATCCTGGGTAAGTTTTGGTTATAAGTTACCTATTTCCCTCCAAATTATTATATTT CATTCATTACCCCAGTGTCTAGTGTACATACACTGGGAAACCTAGTACTTCTAATATGAAGAATGGGAGAAATGAAAGGTATAATGTTTC TTGAAATAAATAATATAATTGTCCTTATTAATTATATTATGAGGACAGAAGATATTCTGATAAGAGAGAACGTGGTGCTTTGCTTACCGT TTTAAAGAAAATTTGTAAAACTAAAGACTTTTTGAAAAAAAGCTATCTTAAGTGCTTTTTCTTTATTTACAAGACATTTCCCCCAGTGGT AGCATCTGAAGTATTGGAGTGTTTCTGCCACGAAGCAAAGCTCCATTCATGGCCGTCATGGAAGGTTATTTATTAATGTTACATAATGGT AGAATATTACTAGTTAGAGGGTTGGATTTGACTTGGTCCTAAGGCCACAGAATCTCTCTCATGGCTTCCTAAGGGATGTACCTTTATGCT TTTAAGAACTACAAAGATTCAATAAAGAAAGAAATGTTTTTGAAACTATAGAAAAAGATTTTAAAACACGCTGCTGTCCTAAACAAATCC TGTTTAAAGGAATTTTAAAGAGATGCATTTTACTATATCAAAGAACATACGTGTATTTGCCTAAACACTCTGTACCTTTGTAATGATAAA ACTTCCCCCTTCTTTACGGTGAAGCTTATTCTGATTAAGCCTAGACTGTGTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTGGTCTGATGATGAATTTGTGAACTCTATCTTTGGTATATCTTTTATTAAACTGCACTGTTTTGTTTAGTCAAGGTAATTAAG TAATTATGTATTTGAATAACTTGGTGTGTCTTGAGTGTTGTGGTATGAAAAGCATTGTGGTCTTTCTACACTAATGAAGTGCAAATAAAA >70480_70480_1_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000332175_RAB12_chr18_8624936_ENST00000329286_length(amino acids)=690AA_BP=1 MGLGLPVERRRAERARPRPRPPPRPRPAARVPGPGQGKGRGGELSNRNRGKILAPRARPPLPLPAAPDAEWGQGQGRRTQDPVPAPLEPL EFGLLQLLALWGLGLALCCLPVSPRCLGTKAPGPLRPRAPTHRRRGAARPALSTMRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTC GYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLG NPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGD RLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANS INGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCAGVDFKIKTVELRGKKIRLQ IWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREITRQQGEKFAQQITGMRFCE -------------------------------------------------------------- >70480_70480_2_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000400053_RAB12_chr18_8624936_ENST00000329286_length(transcript)=2999nt_BP=1371nt GTGCTGTGGCCCAATCCTGTGCGTGTCTCCTCTTCAGGCTCCTGCCGGAGCATGCTTCTCTAATCTTACCATTTATCACTGACCCTTCGG TGAAACTCTCTTCTGTTTAAATTTACCAGGGTACACTTTGTAATACTTGGGACCAAGAATTTGAAGATAGTAATCAGACAAATCAAACAA CTAGTAGTAGTGGAGAGACACGTAGCCCTACAGGAAGGGGTAGAATTATCATTAAAAACACAGACAAACCAGAGACTGCCTGAAAAAAAA AAAAAGATGAACTGGAAAGATTCAAAGTAGGCTCTATTGGAGGTGGCTGCCTCTTTGATGAGCCGTATAGCACATGTGGATATAGTCAAT CTGAAGGTGATGACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGATCCATGGATGCCATCAGGTTCTTTCATGCTGG TGAATGCCTCTGGGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACT ATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGA ATATATCTGGAGACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAG TGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGA TTCAGAATGTGGAAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTAC AGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCA CCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAAC CACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATG GGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTG GACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCA GGACAAGAACAAAGTGTGCTGGTGTTGACTTCAAAATCAAAACTGTAGAGCTAAGAGGAAAGAAAATTAGATTACAGATCTGGGACACAG CAGGTCAGGAGAGATTCAACAGCATTACCTCAGCTTATTACAGAAGTGCCAAGGGGATCATATTAGTATATGATATCACTAAGAAGGAGA CATTTGATGATTTGCCGAAATGGATGAAGATGATTGATAAGTATGCTTCAGAAGATGCAGAGCTTCTCTTAGTTGGAAATAAGTTGGACT GTGAAACGGACAGAGAAATCACCAGGCAGCAGGGGGAAAAGTTTGCACAGCAGATCACTGGGATGCGGTTCTGTGAAGCAAGTGCCAAGG ATAACTTCAATGTGGACGAGATATTTTTGAAACTTGTCGATGACATTCTGAAAAAGATGCCTCTGGATATTTTAAGGAATGAGTTGTCCA ATAGTATCCTGTCGTTACAACCAGAGCCTGAGATACCGCCAGAACTGCCTCCACCAAGACCACATGTCCGATGCTGTTGATTTCCTACTT TGGAGACAAAGTGGAAATGATTCCTGGAAAGGGGAAAAAACGTTCTATTCTGCACTACAATCATTTTGACAATTTCCTTTCGCACTTTGT AATCCAAGTCAGAGCTATACACTAACTTGTAAATATGCATATATGCAATCCTGGGTAAGTTTTGGTTATAAGTTACCTATTTCCCTCCAA ATTATTATATTTCATTCATTACCCCAGTGTCTAGTGTACATACACTGGGAAACCTAGTACTTCTAATATGAAGAATGGGAGAAATGAAAG GTATAATGTTTCTTGAAATAAATAATATAATTGTCCTTATTAATTATATTATGAGGACAGAAGATATTCTGATAAGAGAGAACGTGGTGC TTTGCTTACCGTTTTAAAGAAAATTTGTAAAACTAAAGACTTTTTGAAAAAAAGCTATCTTAAGTGCTTTTTCTTTATTTACAAGACATT TCCCCCAGTGGTAGCATCTGAAGTATTGGAGTGTTTCTGCCACGAAGCAAAGCTCCATTCATGGCCGTCATGGAAGGTTATTTATTAATG TTACATAATGGTAGAATATTACTAGTTAGAGGGTTGGATTTGACTTGGTCCTAAGGCCACAGAATCTCTCTCATGGCTTCCTAAGGGATG TACCTTTATGCTTTTAAGAACTACAAAGATTCAATAAAGAAAGAAATGTTTTTGAAACTATAGAAAAAGATTTTAAAACACGCTGCTGTC CTAAACAAATCCTGTTTAAAGGAATTTTAAAGAGATGCATTTTACTATATCAAAGAACATACGTGTATTTGCCTAAACACTCTGTACCTT TGTAATGATAAAACTTCCCCCTTCTTTACGGTGAAGCTTATTCTGATTAAGCCTAGACTGTGTTCTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTGGTCTGATGATGAATTTGTGAACTCTATCTTTGGTATATCTTTTATTAAACTGCACTGTTTTGTTTAGTC AAGGTAATTAAGTAATTATGTATTTGAATAACTTGGTGTGTCTTGAGTGTTGTGGTATGAAAAGCATTGTGGTCTTTCTACACTAATGAA >70480_70480_2_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000400053_RAB12_chr18_8624936_ENST00000329286_length(amino acids)=532AA_BP=1 MERFKVGSIGGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVS SKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNV EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVP IAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRT KCAGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETD -------------------------------------------------------------- >70480_70480_3_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000400060_RAB12_chr18_8624936_ENST00000329286_length(transcript)=2760nt_BP=1132nt ATGAGGGGACTTGGGACTTGCCTGGCGACTTTGGCCGGACTTTTGCTAACTGCGGCGGGCGAGACGTTCTCAGGTGGCTGCCTCTTTGAT GAGCCGTATAGCACATGTGGATATAGTCAATCTGAAGGTGATGACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGAT CCATGGATGCCATCAGGTTCTTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAA GAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTC AATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTC TGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACAT CCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGC AGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGC TTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATA TCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATA CAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGG CAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAG GGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGGTGTTGACTTCAAAATCAAAACTGTAGAGCTAAGAGGA AAGAAAATTAGATTACAGATCTGGGACACAGCAGGTCAGGAGAGATTCAACAGCATTACCTCAGCTTATTACAGAAGTGCCAAGGGGATC ATATTAGTATATGATATCACTAAGAAGGAGACATTTGATGATTTGCCGAAATGGATGAAGATGATTGATAAGTATGCTTCAGAAGATGCA GAGCTTCTCTTAGTTGGAAATAAGTTGGACTGTGAAACGGACAGAGAAATCACCAGGCAGCAGGGGGAAAAGTTTGCACAGCAGATCACT GGGATGCGGTTCTGTGAAGCAAGTGCCAAGGATAACTTCAATGTGGACGAGATATTTTTGAAACTTGTCGATGACATTCTGAAAAAGATG CCTCTGGATATTTTAAGGAATGAGTTGTCCAATAGTATCCTGTCGTTACAACCAGAGCCTGAGATACCGCCAGAACTGCCTCCACCAAGA CCACATGTCCGATGCTGTTGATTTCCTACTTTGGAGACAAAGTGGAAATGATTCCTGGAAAGGGGAAAAAACGTTCTATTCTGCACTACA ATCATTTTGACAATTTCCTTTCGCACTTTGTAATCCAAGTCAGAGCTATACACTAACTTGTAAATATGCATATATGCAATCCTGGGTAAG TTTTGGTTATAAGTTACCTATTTCCCTCCAAATTATTATATTTCATTCATTACCCCAGTGTCTAGTGTACATACACTGGGAAACCTAGTA CTTCTAATATGAAGAATGGGAGAAATGAAAGGTATAATGTTTCTTGAAATAAATAATATAATTGTCCTTATTAATTATATTATGAGGACA GAAGATATTCTGATAAGAGAGAACGTGGTGCTTTGCTTACCGTTTTAAAGAAAATTTGTAAAACTAAAGACTTTTTGAAAAAAAGCTATC TTAAGTGCTTTTTCTTTATTTACAAGACATTTCCCCCAGTGGTAGCATCTGAAGTATTGGAGTGTTTCTGCCACGAAGCAAAGCTCCATT CATGGCCGTCATGGAAGGTTATTTATTAATGTTACATAATGGTAGAATATTACTAGTTAGAGGGTTGGATTTGACTTGGTCCTAAGGCCA CAGAATCTCTCTCATGGCTTCCTAAGGGATGTACCTTTATGCTTTTAAGAACTACAAAGATTCAATAAAGAAAGAAATGTTTTTGAAACT ATAGAAAAAGATTTTAAAACACGCTGCTGTCCTAAACAAATCCTGTTTAAAGGAATTTTAAAGAGATGCATTTTACTATATCAAAGAACA TACGTGTATTTGCCTAAACACTCTGTACCTTTGTAATGATAAAACTTCCCCCTTCTTTACGGTGAAGCTTATTCTGATTAAGCCTAGACT GTGTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGATGATGAATTTGTGAACTCTATCTTTGGTATAT CTTTTATTAAACTGCACTGTTTTGTTTAGTCAAGGTAATTAAGTAATTATGTATTTGAATAACTTGGTGTGTCTTGAGTGTTGTGGTATG >70480_70480_3_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000400060_RAB12_chr18_8624936_ENST00000329286_length(amino acids)=546AA_BP=0 MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLK ENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGI SNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE GGTGSPGPALRTRTKCAGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDA ELLLVGNKLDCETDREITRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDILRNELSNSILSLQPEPEIPPELPPPR -------------------------------------------------------------- >70480_70480_4_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000444013_RAB12_chr18_8624936_ENST00000329286_length(transcript)=2121nt_BP=493nt ATGGGAACCCTCTCCCTCCATCCTGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCT TCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTAT GCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAAC GCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTC GATTCCACGAGCTATAAAATTGGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACT GGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGGTGTTGACTTCAAAATCAAAACTGTAGAGCTAAGAGGAAAGAAAATT AGATTACAGATCTGGGACACAGCAGGTCAGGAGAGATTCAACAGCATTACCTCAGCTTATTACAGAAGTGCCAAGGGGATCATATTAGTA TATGATATCACTAAGAAGGAGACATTTGATGATTTGCCGAAATGGATGAAGATGATTGATAAGTATGCTTCAGAAGATGCAGAGCTTCTC TTAGTTGGAAATAAGTTGGACTGTGAAACGGACAGAGAAATCACCAGGCAGCAGGGGGAAAAGTTTGCACAGCAGATCACTGGGATGCGG TTCTGTGAAGCAAGTGCCAAGGATAACTTCAATGTGGACGAGATATTTTTGAAACTTGTCGATGACATTCTGAAAAAGATGCCTCTGGAT ATTTTAAGGAATGAGTTGTCCAATAGTATCCTGTCGTTACAACCAGAGCCTGAGATACCGCCAGAACTGCCTCCACCAAGACCACATGTC CGATGCTGTTGATTTCCTACTTTGGAGACAAAGTGGAAATGATTCCTGGAAAGGGGAAAAAACGTTCTATTCTGCACTACAATCATTTTG ACAATTTCCTTTCGCACTTTGTAATCCAAGTCAGAGCTATACACTAACTTGTAAATATGCATATATGCAATCCTGGGTAAGTTTTGGTTA TAAGTTACCTATTTCCCTCCAAATTATTATATTTCATTCATTACCCCAGTGTCTAGTGTACATACACTGGGAAACCTAGTACTTCTAATA TGAAGAATGGGAGAAATGAAAGGTATAATGTTTCTTGAAATAAATAATATAATTGTCCTTATTAATTATATTATGAGGACAGAAGATATT CTGATAAGAGAGAACGTGGTGCTTTGCTTACCGTTTTAAAGAAAATTTGTAAAACTAAAGACTTTTTGAAAAAAAGCTATCTTAAGTGCT TTTTCTTTATTTACAAGACATTTCCCCCAGTGGTAGCATCTGAAGTATTGGAGTGTTTCTGCCACGAAGCAAAGCTCCATTCATGGCCGT CATGGAAGGTTATTTATTAATGTTACATAATGGTAGAATATTACTAGTTAGAGGGTTGGATTTGACTTGGTCCTAAGGCCACAGAATCTC TCTCATGGCTTCCTAAGGGATGTACCTTTATGCTTTTAAGAACTACAAAGATTCAATAAAGAAAGAAATGTTTTTGAAACTATAGAAAAA GATTTTAAAACACGCTGCTGTCCTAAACAAATCCTGTTTAAAGGAATTTTAAAGAGATGCATTTTACTATATCAAAGAACATACGTGTAT TTGCCTAAACACTCTGTACCTTTGTAATGATAAAACTTCCCCCTTCTTTACGGTGAAGCTTATTCTGATTAAGCCTAGACTGTGTTCTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTCTGATGATGAATTTGTGAACTCTATCTTTGGTATATCTTTTATTA AACTGCACTGTTTTGTTTAGTCAAGGTAATTAAGTAATTATGTATTTGAATAACTTGGTGTGTCTTGAGTGTTGTGGTATGAAAAGCATT >70480_70480_4_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000444013_RAB12_chr18_8624936_ENST00000329286_length(amino acids)=333AA_BP=0 MGTLSLHPGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN ANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCAGVDFKIKTVELRGKKI RLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREITRQQGEKFAQQITGMR -------------------------------------------------------------- >70480_70480_5_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000580170_RAB12_chr18_8624936_ENST00000329286_length(transcript)=3797nt_BP=2169nt GCGGCGTAGAGAAGCTCGCAGCCCTCCGGAGCCTCAGCGATCTCCTGGCTCGCTTTTCCCGCAGCCGCCGAGCAGCGCAGGCCCGGCGAC TCCGGGTGCAGCTGGCCCTGTGCGGTGACATCGCCGTCCGGCGCCAGGCTCGAAGCCGCCTGGCCGCGCCCGCGGGGTCGCAGGCCGCTG GTCCCGCCCGGCCGCGCTCACAAACTACTCGCGGCTCGTGACCCGGGACAAACTTCTGGCGGCGGCGCAGCCTCTTCCACAGTCACCCTC CCCAGAGCCAGCTACCAAAATAGAAGACGCGGCCGGGGCGAGGAGGTGGGCGGGGGGAGCCCGGTGGCCGCTCCTCCCCGCGCGGCTGAC GCCCGCTTCGGCGGCGGTAGTGGCTGTGGCCGCGGGGCCGCCCCCAGCCGAGCTCCCGGAGGCGCTCGGGCGCGGGCCGGCGGGGCACGG GCGCTCACGCCCTCTAGCGGGCCGCGGCGGCGCCGGGCGGCCGTGACGTGAGCGCTCCCTTCAGCCGGCCTGCGGGGCACCGCCAGTCAG TCGGGGAGCAAGAGCCCCGCGCGCAGCCGGCGCGGGCTCGGTCATCGGCGCGCCGCCGCCCGGGGCTGGGCTTGGGGCTGCCTGTGGAGA GGCGGCGGGCGGAACGCGCGCGGCCACGGCCACGGCCACCGCCACGGCCACGGCCGGCAGCTCGGGTCCCGGGTCCCGGGCAGGGGAAGG GGAGAGGCGGCGAGCTCAGCAACCGGAACCGAGGGAAGATTTTGGCTCCGCGGGCTCGCCCTCCGCTCCCTCTGCCAGCGGCGCCAGACG CCGAGTGGGGCCAGGGACAGGGGAGGAGGACCCAGGACCCTGTGCCCGCGCCCCTGGAGCCGCTGGAGTTCGGACTTCTGCAACTGTTGG CACTTTGGGGGCTTGGCTTAGCGCTCTGCTGTTTACCCGTCTCTCCTCGCTGCCTCGGAACCAAAGCTCCCGGCCCCCTCCGCCCTCGCG CGCCCACCCACCGCCGCCGGGGAGCGGCCCGGCCCGCACTCAGCACCATGAGGGGACTTGGGACTTGCCTGGCGACTTTGGCCGGACTTT TGCTAACTGCGGCGGGCGAGACGTTCTCAGGTGGCTGCCTCTTTGATGAGCCGTATAGCACATGTGGATATAGTCAATCTGAAGGTGATG ACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGATCCATGGATGCCATCAGGTTCTTTCATGCTGGTGAATGCCTCTG GGAGACCTGAGGGGCAGAGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCACTATTTTGTGTCCA GCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTCAATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAG ACCCAACACGTACATGGAACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAAGTGATAACTTCTG GACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACATCCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGG AAGTTAATGCTGGCCAGTTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTACAGGGCATTGATG TGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGCTTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATG CTGGAAAGTACCGCTGCATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAACCACCCGTTCCTA TTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATACAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGG CCCGAGAGGTGGAGTACTGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATTGGACACCTTGACC CAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAGGGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAA AGTGTGCTGGTGTTGACTTCAAAATCAAAACTGTAGAGCTAAGAGGAAAGAAAATTAGATTACAGATCTGGGACACAGCAGGTCAGGAGA GATTCAACAGCATTACCTCAGCTTATTACAGAAGTGCCAAGGGGATCATATTAGTATATGATATCACTAAGAAGGAGACATTTGATGATT TGCCGAAATGGATGAAGATGATTGATAAGTATGCTTCAGAAGATGCAGAGCTTCTCTTAGTTGGAAATAAGTTGGACTGTGAAACGGACA GAGAAATCACCAGGCAGCAGGGGGAAAAGTTTGCACAGCAGATCACTGGGATGCGGTTCTGTGAAGCAAGTGCCAAGGATAACTTCAATG TGGACGAGATATTTTTGAAACTTGTCGATGACATTCTGAAAAAGATGCCTCTGGATATTTTAAGGAATGAGTTGTCCAATAGTATCCTGT CGTTACAACCAGAGCCTGAGATACCGCCAGAACTGCCTCCACCAAGACCACATGTCCGATGCTGTTGATTTCCTACTTTGGAGACAAAGT GGAAATGATTCCTGGAAAGGGGAAAAAACGTTCTATTCTGCACTACAATCATTTTGACAATTTCCTTTCGCACTTTGTAATCCAAGTCAG AGCTATACACTAACTTGTAAATATGCATATATGCAATCCTGGGTAAGTTTTGGTTATAAGTTACCTATTTCCCTCCAAATTATTATATTT CATTCATTACCCCAGTGTCTAGTGTACATACACTGGGAAACCTAGTACTTCTAATATGAAGAATGGGAGAAATGAAAGGTATAATGTTTC TTGAAATAAATAATATAATTGTCCTTATTAATTATATTATGAGGACAGAAGATATTCTGATAAGAGAGAACGTGGTGCTTTGCTTACCGT TTTAAAGAAAATTTGTAAAACTAAAGACTTTTTGAAAAAAAGCTATCTTAAGTGCTTTTTCTTTATTTACAAGACATTTCCCCCAGTGGT AGCATCTGAAGTATTGGAGTGTTTCTGCCACGAAGCAAAGCTCCATTCATGGCCGTCATGGAAGGTTATTTATTAATGTTACATAATGGT AGAATATTACTAGTTAGAGGGTTGGATTTGACTTGGTCCTAAGGCCACAGAATCTCTCTCATGGCTTCCTAAGGGATGTACCTTTATGCT TTTAAGAACTACAAAGATTCAATAAAGAAAGAAATGTTTTTGAAACTATAGAAAAAGATTTTAAAACACGCTGCTGTCCTAAACAAATCC TGTTTAAAGGAATTTTAAAGAGATGCATTTTACTATATCAAAGAACATACGTGTATTTGCCTAAACACTCTGTACCTTTGTAATGATAAA ACTTCCCCCTTCTTTACGGTGAAGCTTATTCTGATTAAGCCTAGACTGTGTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTGGTCTGATGATGAATTTGTGAACTCTATCTTTGGTATATCTTTTATTAAACTGCACTGTTTTGTTTAGTCAAGGTAATTAAG TAATTATGTATTTGAATAACTTGGTGTGTCTTGAGTGTTGTGGTATGAAAAGCATTGTGGTCTTTCTACACTAATGAAGTGCAAATAAAA >70480_70480_5_PTPRM-RAB12_PTPRM_chr18_7955412_ENST00000580170_RAB12_chr18_8624936_ENST00000329286_length(amino acids)=690AA_BP=1 MGLGLPVERRRAERARPRPRPPPRPRPAARVPGPGQGKGRGGELSNRNRGKILAPRARPPLPLPAAPDAEWGQGQGRRTQDPVPAPLEPL EFGLLQLLALWGLGLALCCLPVSPRCLGTKAPGPLRPRAPTHRRRGAARPALSTMRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTC GYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLG NPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGD RLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANS INGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCAGVDFKIKTVELRGKKIRLQ IWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREITRQQGEKFAQQITGMRFCE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PTPRM-RAB12 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PTPRM-RAB12 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PTPRM-RAB12 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |