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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PTPRZ1-MDFIC (FusionGDB2 ID:70585) |
Fusion Gene Summary for PTPRZ1-MDFIC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPRZ1-MDFIC | Fusion gene ID: 70585 | Hgene | Tgene | Gene symbol | PTPRZ1 | MDFIC | Gene ID | 5803 | 29969 |
| Gene name | protein tyrosine phosphatase receptor type Z1 | MyoD family inhibitor domain containing | |
| Synonyms | HPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan | HIC|MDFIC1 | |
| Cytomap | 7q31.32 | 7q31.1-q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine | myoD family inhibitor domain-containing proteinI-mfa domain-containing protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9P1T7 | |
| Ensembl transtripts involved in fusion gene | ENST00000393386, ENST00000449182, ENST00000483028, | ENST00000423503, ENST00000448022, ENST00000257724, ENST00000393486, | |
| Fusion gene scores | * DoF score | 15 X 14 X 7=1470 | 2 X 2 X 2=8 |
| # samples | 19 | 2 | |
| ** MAII score | log2(19/1470*10)=-2.95174483139278 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PTPRZ1 [Title/Abstract] AND MDFIC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PTPRZ1(121608184)-MDFIC(114582330), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MDFIC | GO:0007257 | activation of JUN kinase activity | 12192039 |
| Tgene | MDFIC | GO:0030111 | regulation of Wnt signaling pathway | 12192039 |
| Tgene | MDFIC | GO:0045893 | positive regulation of transcription, DNA-templated | 12944466 |
| Tgene | MDFIC | GO:0050434 | positive regulation of viral transcription | 10671520 |
| Fusion gene breakpoints across PTPRZ1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MDFIC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-D7-8576-01A | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
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Fusion Gene ORF analysis for PTPRZ1-MDFIC |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000393386 | ENST00000423503 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| 5CDS-intron | ENST00000393386 | ENST00000448022 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| 5CDS-intron | ENST00000449182 | ENST00000423503 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| 5CDS-intron | ENST00000449182 | ENST00000448022 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| In-frame | ENST00000393386 | ENST00000257724 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| In-frame | ENST00000393386 | ENST00000393486 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| In-frame | ENST00000449182 | ENST00000257724 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| In-frame | ENST00000449182 | ENST00000393486 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| intron-3CDS | ENST00000483028 | ENST00000257724 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| intron-3CDS | ENST00000483028 | ENST00000393486 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| intron-intron | ENST00000483028 | ENST00000423503 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| intron-intron | ENST00000483028 | ENST00000448022 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393386 | PTPRZ1 | chr7 | 121608184 | - | ENST00000393486 | MDFIC | chr7 | 114582330 | + | 4629 | 715 | 192 | 1361 | 389 |
| ENST00000393386 | PTPRZ1 | chr7 | 121608184 | - | ENST00000257724 | MDFIC | chr7 | 114582330 | + | 4629 | 715 | 192 | 1361 | 389 |
| ENST00000449182 | PTPRZ1 | chr7 | 121608184 | - | ENST00000393486 | MDFIC | chr7 | 114582330 | + | 4357 | 443 | 91 | 1089 | 332 |
| ENST00000449182 | PTPRZ1 | chr7 | 121608184 | - | ENST00000257724 | MDFIC | chr7 | 114582330 | + | 4357 | 443 | 91 | 1089 | 332 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393386 | ENST00000393486 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + | 8.84E-05 | 0.99991155 |
| ENST00000393386 | ENST00000257724 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + | 8.84E-05 | 0.99991155 |
| ENST00000449182 | ENST00000393486 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + | 7.69E-05 | 0.9999231 |
| ENST00000449182 | ENST00000257724 | PTPRZ1 | chr7 | 121608184 | - | MDFIC | chr7 | 114582330 | + | 7.69E-05 | 0.9999231 |
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Fusion Genomic Features for PTPRZ1-MDFIC |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PTPRZ1-MDFIC |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:121608184/chr7:114582330) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MDFIC |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MDFIC | chr7:121608184 | chr7:114582330 | ENST00000393486 | 1 | 5 | 166_243 | 31 | 247.0 | Compositional bias | Note=Cys-rich | |
| Tgene | MDFIC | chr7:121608184 | chr7:114582330 | ENST00000393486 | 1 | 5 | 74_246 | 31 | 247.0 | Domain | Note=MDFI |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 1717_1992 | 101 | 2316.0 | Domain | Tyrosine-protein phosphatase 1 |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 2023_2282 | 101 | 2316.0 | Domain | Tyrosine-protein phosphatase 2 |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 314_413 | 101 | 2316.0 | Domain | Fibronectin type-III |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 36_300 | 101 | 2316.0 | Domain | Alpha-carbonic anhydrase |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 1933_1939 | 101 | 2316.0 | Region | Substrate binding |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 1663_2315 | 101 | 2316.0 | Topological domain | Cytoplasmic |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 25_1636 | 101 | 2316.0 | Topological domain | Extracellular |
| Hgene | PTPRZ1 | chr7:121608184 | chr7:114582330 | ENST00000393386 | - | 3 | 30 | 1637_1662 | 101 | 2316.0 | Transmembrane | Helical |
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Fusion Gene Sequence for PTPRZ1-MDFIC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >70585_70585_1_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000393386_MDFIC_chr7_114582330_ENST00000257724_length(transcript)=4629nt_BP=715nt AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGGAAAA TGTGATAAAGACAATACTGAGAAAGATATAACTCAAGCTACCAATAGCCACTTCACACATGGAGAGATGCAAGACCAGTCCATTTGGGGA AATCCTTCGGATGGTGAACTCATTAGAACCCAACCTCAGCGCTTGCCTCAGCTTCAGACTTCAGCCCAGGTGCCAAGTGGTGAGGAAATA GGCAAGATAAAGAACGGCCACACAGGTCTGAGCAATGGAAATGGAATTCACCACGGGGCCAAACACGGATCCGCAGATAATCGCAAACTT TCAGCACCTGTTTCTCAAAAAATGCATAGAAAAATTCAGTCCAGCTTGTCTGTAAACAGCGATATCAGTAAGAAGAGCAAAGTAAATGCT GTCTTTTCCCAAAAGACAGGCTCTTCACCTGAAGATTGTTGTGTCCACTGTATCCTGGCTTGCTTGTTCTGCGAATTCCTGACCCTTTGC AACATTGTCCTGGGACAAGCGTCATGTGGCATCTGCACCTCAGAAGCCTGCTGCTGTTGCTGTGGTGACGAGATGGGGGATGATTGTAAC TGCCCTTGTGATATGGACTGTGGCATCATGGATGCCTGTTGTGAATCATCAGACTGCTTGGAAATCTGTATGGAATGCTGTGGAATTTGT TTTCCTTCATAAATATTTATCTTTTGTTTGTGTTAAAACTGGAGAGTGTTTAAAAATTTCCTTTTGGGGGGAAGAAAAGCACATTGTAAG ATTCTCATGAAACAACATGGAATTTGCACTGTTAACTCATTATTGTAAGTAATCTCTGAAAGCCTTTTTACTTTAACCAAATCTACATGG TTTAATATGTGAAATTTTAACTACTTTAACTAGTTTTATAAATTTCTTAATATGTTACAATAACTTAGGGACATTTTGACACCCCCCTTC CCAAATGTTAAATGCCTTCTCCTTTTTACCGATATTTCTGTTTCTTTTAACCGTTCTCAGGAGCACTTTGCTCCAAATATATTATTTTTC AGTGTGTATTTAAACGAGGCAGTTTATTTTGATATGTATCTATTCATGATTGAAAGGAAGCAGTCTTGGCCAGGCACGGTGGCTTACACC TGTAACCCTGGCATTTTGGGAGGCCAAGGTGGGCAGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCAGGGCAACATGGTGAAACCCCAT CTCTACTAAAATACAAAAAGTTAGCTGGGCTTGGCGGTGTGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA ACCCGAGAGGCGGAAGTTGCAGTGAGCCGAGATTGTGCCACTGAACTCCAACCTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCT CTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAACAAACCAGTCTTTATTTTAAAAGAAACTTTAGGAAACAAACCCAC ATAATAGTTGGGAACCAGTGTTGATCTCTCTCCCTTACCTTCTCCACTTGTTCAACAGACTCTGAATGCCGACTGTGTGGACTCTCTTCC TCAGACTGTGGGGACAGATACAATTCCACTCCTGTCCACAGGAACATGAGATTTAGCAGACTAAGGAGATCTGTAAAGAATGAACCATAC CACAAGGCATACTGAAGTGAGGATTATAAGAGAAATAAACTCAAAATGCTGTTGGAATATGCAGAGAATTGCTACCAGAATATTCAGTAA GGTTTCAGGGAGAATGTGGCATTTGAGGACTCTCTTAGAATGAGTGATTCACCTGCTATTTAAATGAATTATTTAGATTTTTGACAAAGA TTTAGGTGGACACCCTAAACTGTGTGTGCCTTTAACCAGTTAAAAGAACAGTGCCTTCAGCATACTTTTTTATTAGTTGTAGGAATACAG CTTTTTGAAAAAGCTATAAAGTTTAAATTAACTAAAAATATGCATTTTCTTACACATAATTTAAATGTTATCATACTTTTTTGATGAAAA CATAATGCCTTAGTAAAATAGCTCTATTTAATAAAGAAGATTGAGTACTCTGACACATTTCATTTAAATTAGGAAATTTTTAATATTAAA ATCCCAGTGTTCTGAGTTATTGAAAGGCTTTCTTTTATTTTGAGAGCTTTAGGTCTTTTTGGGATGAGAACATTTTAGTTGTTTAGTTTG TTTCTTAAGCAGTGCTATTTTTTGTAAACACAGATAAATGGAAACCATTCTTTTCAATGCAGAAGAAATCTAGATATCCCCTACTGTGAC CAAATTTCTGTATTACGATTTTATGTTAAATTAAACTAATATGGCAGGTTATAATGATCCTTAAGTGTAAAGAAATCAGTCAATTACAAG AGTAATTGTATAGTTATTGAGACCTATAGTGTGTGGCTTAGATGAAAGGGAGAGTAAATTTTCATACCATGCTCTCTCCTACTCAGTTTG ATCTCTCTAAAATTGTAGTTTGGTTTGATTTAATATAATTCTTAGTAGAAATTTTGAAAGTATGCTTTGGGATTAATAATTATTTTTAAT TTTTCTGGCTGAATATCAAATTGATAGTAACAACAGAAGCATAATTTTAGGAAGGCTTTCGCAAACCTAGCCTTTTAAGAGAGGTTTTTA ACCTGAAGCATGAGAATATATCACCTGTGGTTTTTCCTTTGAGATGAAACGTAGTTTCTAGTTATATCATTACTTAAAGGGCTTAAAAAG AAAAAACTTAGCAAACTTTTGAATCTTTCTTTTATTGCTATTTACACATACATACACACATACAAAACCTTTAAATTTTGGGATCTGAAT ATAATTCTGGTAAACAGCTGTCTTCATTTTTCTCCTCTAAAGAACTTAATTCATTTGTTACATAAAATATAAGGAAATCTTTATACTATT TTACAGTAACCACAATCTAAATATTTACATATACCCAAAATTAACTTATGCTCATATATTAGGATGTGAGAATATCATCTGTTTATGGAC ACATGAAACCTCCTAATGACCTGGAATTGTTAGAATATTTGACTTTTTATATGCAAAGTTTTTCAACCAAGTGGTTTGTCTAATATTTAA ACATGTACTGGCACAATTTGTGATGAAAATATTAGCACATTTGCAATAATGTTTCTCCATAACAGAGAATGTTAATGGATACCAGAATTT TATTTTTGTATTTATGTTCATAGTACTTTTCCTCTTGTCTACTCCAGACAGTTATTCCATAAAGCATTTGTATAATTAAAAGGAAAACAG AAAAAGGAAAAGTAGGCAAATGTGAAAATAGTTTCAATATATCTTATGATTTCTTAATGTAAAATGTTTTGTTGAAGTATATGGCTATCA TGACTAAGTGCTAGAATTTATAGTTACAGGCGGTGTCCTTTTAAATGTGGAAAGGCTTTTAAAATATTTTAAAACTGGACCTGTATTATC CTGAATACACTATTTTGAAAATTTTTAAAAATGACTTCTTTATTTTGCTTTACCGTATGTTTATATCTAATTGACATATTGACTAATGTT TGAAAGAATTCAACCATAAGTTAAAATCTGAAGGTTATCTTTATCATGTTTCATCCCTGTCTGAAGATTTCCTAGTCTTCTTATGTAAAT CACATGACTCATGTCCGTAAATGAACTATGAAAGATATCGATCAGTTTATGATCATTGACATGTGATTTCAAAACACAGTGTTCTTTTAA AAATCTATAATATGTCAAAATACAAGTTTTTTTTTTTTACATCGTTTTAGTAAGTTAATTTCATTTATTTACTTTGGAGCTATATTTCCA CTTAGAAAAACTAAGGTAATTTTACAATATATGCTGAGATTAAAAACCAAGGTAAAAATGATCAAACATATATGAAATTGAGTCTTAGAT >70585_70585_1_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000393386_MDFIC_chr7_114582330_ENST00000257724_length(amino acids)=389AA_BP=1 MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTGKCDKD NTEKDITQATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNGHTGLSNGNGIHHGAKHGSADNRKLSAPV SQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTGSSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCNCPCD -------------------------------------------------------------- >70585_70585_2_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000393386_MDFIC_chr7_114582330_ENST00000393486_length(transcript)=4629nt_BP=715nt AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGGAAAA TGTGATAAAGACAATACTGAGAAAGATATAACTCAAGCTACCAATAGCCACTTCACACATGGAGAGATGCAAGACCAGTCCATTTGGGGA AATCCTTCGGATGGTGAACTCATTAGAACCCAACCTCAGCGCTTGCCTCAGCTTCAGACTTCAGCCCAGGTGCCAAGTGGTGAGGAAATA GGCAAGATAAAGAACGGCCACACAGGTCTGAGCAATGGAAATGGAATTCACCACGGGGCCAAACACGGATCCGCAGATAATCGCAAACTT TCAGCACCTGTTTCTCAAAAAATGCATAGAAAAATTCAGTCCAGCTTGTCTGTAAACAGCGATATCAGTAAGAAGAGCAAAGTAAATGCT GTCTTTTCCCAAAAGACAGGCTCTTCACCTGAAGATTGTTGTGTCCACTGTATCCTGGCTTGCTTGTTCTGCGAATTCCTGACCCTTTGC AACATTGTCCTGGGACAAGCGTCATGTGGCATCTGCACCTCAGAAGCCTGCTGCTGTTGCTGTGGTGACGAGATGGGGGATGATTGTAAC TGCCCTTGTGATATGGACTGTGGCATCATGGATGCCTGTTGTGAATCATCAGACTGCTTGGAAATCTGTATGGAATGCTGTGGAATTTGT TTTCCTTCATAAATATTTATCTTTTGTTTGTGTTAAAACTGGAGAGTGTTTAAAAATTTCCTTTTGGGGGGAAGAAAAGCACATTGTAAG ATTCTCATGAAACAACATGGAATTTGCACTGTTAACTCATTATTGTAAGTAATCTCTGAAAGCCTTTTTACTTTAACCAAATCTACATGG TTTAATATGTGAAATTTTAACTACTTTAACTAGTTTTATAAATTTCTTAATATGTTACAATAACTTAGGGACATTTTGACACCCCCCTTC CCAAATGTTAAATGCCTTCTCCTTTTTACCGATATTTCTGTTTCTTTTAACCGTTCTCAGGAGCACTTTGCTCCAAATATATTATTTTTC AGTGTGTATTTAAACGAGGCAGTTTATTTTGATATGTATCTATTCATGATTGAAAGGAAGCAGTCTTGGCCAGGCACGGTGGCTTACACC TGTAACCCTGGCATTTTGGGAGGCCAAGGTGGGCAGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCAGGGCAACATGGTGAAACCCCAT CTCTACTAAAATACAAAAAGTTAGCTGGGCTTGGCGGTGTGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA ACCCGAGAGGCGGAAGTTGCAGTGAGCCGAGATTGTGCCACTGAACTCCAACCTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCT CTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAACAAACCAGTCTTTATTTTAAAAGAAACTTTAGGAAACAAACCCAC ATAATAGTTGGGAACCAGTGTTGATCTCTCTCCCTTACCTTCTCCACTTGTTCAACAGACTCTGAATGCCGACTGTGTGGACTCTCTTCC TCAGACTGTGGGGACAGATACAATTCCACTCCTGTCCACAGGAACATGAGATTTAGCAGACTAAGGAGATCTGTAAAGAATGAACCATAC CACAAGGCATACTGAAGTGAGGATTATAAGAGAAATAAACTCAAAATGCTGTTGGAATATGCAGAGAATTGCTACCAGAATATTCAGTAA GGTTTCAGGGAGAATGTGGCATTTGAGGACTCTCTTAGAATGAGTGATTCACCTGCTATTTAAATGAATTATTTAGATTTTTGACAAAGA TTTAGGTGGACACCCTAAACTGTGTGTGCCTTTAACCAGTTAAAAGAACAGTGCCTTCAGCATACTTTTTTATTAGTTGTAGGAATACAG CTTTTTGAAAAAGCTATAAAGTTTAAATTAACTAAAAATATGCATTTTCTTACACATAATTTAAATGTTATCATACTTTTTTGATGAAAA CATAATGCCTTAGTAAAATAGCTCTATTTAATAAAGAAGATTGAGTACTCTGACACATTTCATTTAAATTAGGAAATTTTTAATATTAAA ATCCCAGTGTTCTGAGTTATTGAAAGGCTTTCTTTTATTTTGAGAGCTTTAGGTCTTTTTGGGATGAGAACATTTTAGTTGTTTAGTTTG TTTCTTAAGCAGTGCTATTTTTTGTAAACACAGATAAATGGAAACCATTCTTTTCAATGCAGAAGAAATCTAGATATCCCCTACTGTGAC CAAATTTCTGTATTACGATTTTATGTTAAATTAAACTAATATGGCAGGTTATAATGATCCTTAAGTGTAAAGAAATCAGTCAATTACAAG AGTAATTGTATAGTTATTGAGACCTATAGTGTGTGGCTTAGATGAAAGGGAGAGTAAATTTTCATACCATGCTCTCTCCTACTCAGTTTG ATCTCTCTAAAATTGTAGTTTGGTTTGATTTAATATAATTCTTAGTAGAAATTTTGAAAGTATGCTTTGGGATTAATAATTATTTTTAAT TTTTCTGGCTGAATATCAAATTGATAGTAACAACAGAAGCATAATTTTAGGAAGGCTTTCGCAAACCTAGCCTTTTAAGAGAGGTTTTTA ACCTGAAGCATGAGAATATATCACCTGTGGTTTTTCCTTTGAGATGAAACGTAGTTTCTAGTTATATCATTACTTAAAGGGCTTAAAAAG AAAAAACTTAGCAAACTTTTGAATCTTTCTTTTATTGCTATTTACACATACATACACACATACAAAACCTTTAAATTTTGGGATCTGAAT ATAATTCTGGTAAACAGCTGTCTTCATTTTTCTCCTCTAAAGAACTTAATTCATTTGTTACATAAAATATAAGGAAATCTTTATACTATT TTACAGTAACCACAATCTAAATATTTACATATACCCAAAATTAACTTATGCTCATATATTAGGATGTGAGAATATCATCTGTTTATGGAC ACATGAAACCTCCTAATGACCTGGAATTGTTAGAATATTTGACTTTTTATATGCAAAGTTTTTCAACCAAGTGGTTTGTCTAATATTTAA ACATGTACTGGCACAATTTGTGATGAAAATATTAGCACATTTGCAATAATGTTTCTCCATAACAGAGAATGTTAATGGATACCAGAATTT TATTTTTGTATTTATGTTCATAGTACTTTTCCTCTTGTCTACTCCAGACAGTTATTCCATAAAGCATTTGTATAATTAAAAGGAAAACAG AAAAAGGAAAAGTAGGCAAATGTGAAAATAGTTTCAATATATCTTATGATTTCTTAATGTAAAATGTTTTGTTGAAGTATATGGCTATCA TGACTAAGTGCTAGAATTTATAGTTACAGGCGGTGTCCTTTTAAATGTGGAAAGGCTTTTAAAATATTTTAAAACTGGACCTGTATTATC CTGAATACACTATTTTGAAAATTTTTAAAAATGACTTCTTTATTTTGCTTTACCGTATGTTTATATCTAATTGACATATTGACTAATGTT TGAAAGAATTCAACCATAAGTTAAAATCTGAAGGTTATCTTTATCATGTTTCATCCCTGTCTGAAGATTTCCTAGTCTTCTTATGTAAAT CACATGACTCATGTCCGTAAATGAACTATGAAAGATATCGATCAGTTTATGATCATTGACATGTGATTTCAAAACACAGTGTTCTTTTAA AAATCTATAATATGTCAAAATACAAGTTTTTTTTTTTTACATCGTTTTAGTAAGTTAATTTCATTTATTTACTTTGGAGCTATATTTCCA CTTAGAAAAACTAAGGTAATTTTACAATATATGCTGAGATTAAAAACCAAGGTAAAAATGATCAAACATATATGAAATTGAGTCTTAGAT >70585_70585_2_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000393386_MDFIC_chr7_114582330_ENST00000393486_length(amino acids)=389AA_BP=1 MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTGKCDKD NTEKDITQATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNGHTGLSNGNGIHHGAKHGSADNRKLSAPV SQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTGSSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCNCPCD -------------------------------------------------------------- >70585_70585_3_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000449182_MDFIC_chr7_114582330_ENST00000257724_length(transcript)=4357nt_BP=443nt CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGGAAAATG TGATAAAGACAATACTGAGAAAGATATAACTCAAGCTACCAATAGCCACTTCACACATGGAGAGATGCAAGACCAGTCCATTTGGGGAAA TCCTTCGGATGGTGAACTCATTAGAACCCAACCTCAGCGCTTGCCTCAGCTTCAGACTTCAGCCCAGGTGCCAAGTGGTGAGGAAATAGG CAAGATAAAGAACGGCCACACAGGTCTGAGCAATGGAAATGGAATTCACCACGGGGCCAAACACGGATCCGCAGATAATCGCAAACTTTC AGCACCTGTTTCTCAAAAAATGCATAGAAAAATTCAGTCCAGCTTGTCTGTAAACAGCGATATCAGTAAGAAGAGCAAAGTAAATGCTGT CTTTTCCCAAAAGACAGGCTCTTCACCTGAAGATTGTTGTGTCCACTGTATCCTGGCTTGCTTGTTCTGCGAATTCCTGACCCTTTGCAA CATTGTCCTGGGACAAGCGTCATGTGGCATCTGCACCTCAGAAGCCTGCTGCTGTTGCTGTGGTGACGAGATGGGGGATGATTGTAACTG CCCTTGTGATATGGACTGTGGCATCATGGATGCCTGTTGTGAATCATCAGACTGCTTGGAAATCTGTATGGAATGCTGTGGAATTTGTTT TCCTTCATAAATATTTATCTTTTGTTTGTGTTAAAACTGGAGAGTGTTTAAAAATTTCCTTTTGGGGGGAAGAAAAGCACATTGTAAGAT TCTCATGAAACAACATGGAATTTGCACTGTTAACTCATTATTGTAAGTAATCTCTGAAAGCCTTTTTACTTTAACCAAATCTACATGGTT TAATATGTGAAATTTTAACTACTTTAACTAGTTTTATAAATTTCTTAATATGTTACAATAACTTAGGGACATTTTGACACCCCCCTTCCC AAATGTTAAATGCCTTCTCCTTTTTACCGATATTTCTGTTTCTTTTAACCGTTCTCAGGAGCACTTTGCTCCAAATATATTATTTTTCAG TGTGTATTTAAACGAGGCAGTTTATTTTGATATGTATCTATTCATGATTGAAAGGAAGCAGTCTTGGCCAGGCACGGTGGCTTACACCTG TAACCCTGGCATTTTGGGAGGCCAAGGTGGGCAGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCAGGGCAACATGGTGAAACCCCATCT CTACTAAAATACAAAAAGTTAGCTGGGCTTGGCGGTGTGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAAC CCGAGAGGCGGAAGTTGCAGTGAGCCGAGATTGTGCCACTGAACTCCAACCTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCTCT AAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAACAAACCAGTCTTTATTTTAAAAGAAACTTTAGGAAACAAACCCACAT AATAGTTGGGAACCAGTGTTGATCTCTCTCCCTTACCTTCTCCACTTGTTCAACAGACTCTGAATGCCGACTGTGTGGACTCTCTTCCTC AGACTGTGGGGACAGATACAATTCCACTCCTGTCCACAGGAACATGAGATTTAGCAGACTAAGGAGATCTGTAAAGAATGAACCATACCA CAAGGCATACTGAAGTGAGGATTATAAGAGAAATAAACTCAAAATGCTGTTGGAATATGCAGAGAATTGCTACCAGAATATTCAGTAAGG TTTCAGGGAGAATGTGGCATTTGAGGACTCTCTTAGAATGAGTGATTCACCTGCTATTTAAATGAATTATTTAGATTTTTGACAAAGATT TAGGTGGACACCCTAAACTGTGTGTGCCTTTAACCAGTTAAAAGAACAGTGCCTTCAGCATACTTTTTTATTAGTTGTAGGAATACAGCT TTTTGAAAAAGCTATAAAGTTTAAATTAACTAAAAATATGCATTTTCTTACACATAATTTAAATGTTATCATACTTTTTTGATGAAAACA TAATGCCTTAGTAAAATAGCTCTATTTAATAAAGAAGATTGAGTACTCTGACACATTTCATTTAAATTAGGAAATTTTTAATATTAAAAT CCCAGTGTTCTGAGTTATTGAAAGGCTTTCTTTTATTTTGAGAGCTTTAGGTCTTTTTGGGATGAGAACATTTTAGTTGTTTAGTTTGTT TCTTAAGCAGTGCTATTTTTTGTAAACACAGATAAATGGAAACCATTCTTTTCAATGCAGAAGAAATCTAGATATCCCCTACTGTGACCA AATTTCTGTATTACGATTTTATGTTAAATTAAACTAATATGGCAGGTTATAATGATCCTTAAGTGTAAAGAAATCAGTCAATTACAAGAG TAATTGTATAGTTATTGAGACCTATAGTGTGTGGCTTAGATGAAAGGGAGAGTAAATTTTCATACCATGCTCTCTCCTACTCAGTTTGAT CTCTCTAAAATTGTAGTTTGGTTTGATTTAATATAATTCTTAGTAGAAATTTTGAAAGTATGCTTTGGGATTAATAATTATTTTTAATTT TTCTGGCTGAATATCAAATTGATAGTAACAACAGAAGCATAATTTTAGGAAGGCTTTCGCAAACCTAGCCTTTTAAGAGAGGTTTTTAAC CTGAAGCATGAGAATATATCACCTGTGGTTTTTCCTTTGAGATGAAACGTAGTTTCTAGTTATATCATTACTTAAAGGGCTTAAAAAGAA AAAACTTAGCAAACTTTTGAATCTTTCTTTTATTGCTATTTACACATACATACACACATACAAAACCTTTAAATTTTGGGATCTGAATAT AATTCTGGTAAACAGCTGTCTTCATTTTTCTCCTCTAAAGAACTTAATTCATTTGTTACATAAAATATAAGGAAATCTTTATACTATTTT ACAGTAACCACAATCTAAATATTTACATATACCCAAAATTAACTTATGCTCATATATTAGGATGTGAGAATATCATCTGTTTATGGACAC ATGAAACCTCCTAATGACCTGGAATTGTTAGAATATTTGACTTTTTATATGCAAAGTTTTTCAACCAAGTGGTTTGTCTAATATTTAAAC ATGTACTGGCACAATTTGTGATGAAAATATTAGCACATTTGCAATAATGTTTCTCCATAACAGAGAATGTTAATGGATACCAGAATTTTA TTTTTGTATTTATGTTCATAGTACTTTTCCTCTTGTCTACTCCAGACAGTTATTCCATAAAGCATTTGTATAATTAAAAGGAAAACAGAA AAAGGAAAAGTAGGCAAATGTGAAAATAGTTTCAATATATCTTATGATTTCTTAATGTAAAATGTTTTGTTGAAGTATATGGCTATCATG ACTAAGTGCTAGAATTTATAGTTACAGGCGGTGTCCTTTTAAATGTGGAAAGGCTTTTAAAATATTTTAAAACTGGACCTGTATTATCCT GAATACACTATTTTGAAAATTTTTAAAAATGACTTCTTTATTTTGCTTTACCGTATGTTTATATCTAATTGACATATTGACTAATGTTTG AAAGAATTCAACCATAAGTTAAAATCTGAAGGTTATCTTTATCATGTTTCATCCCTGTCTGAAGATTTCCTAGTCTTCTTATGTAAATCA CATGACTCATGTCCGTAAATGAACTATGAAAGATATCGATCAGTTTATGATCATTGACATGTGATTTCAAAACACAGTGTTCTTTTAAAA ATCTATAATATGTCAAAATACAAGTTTTTTTTTTTTACATCGTTTTAGTAAGTTAATTTCATTTATTTACTTTGGAGCTATATTTCCACT TAGAAAAACTAAGGTAATTTTACAATATATGCTGAGATTAAAAACCAAGGTAAAAATGATCAAACATATATGAAATTGAGTCTTAGATTT >70585_70585_3_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000449182_MDFIC_chr7_114582330_ENST00000257724_length(amino acids)=332AA_BP=117 MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN VNLKKLKFQGWDKTSLENTFIHNTGKTGKCDKDNTEKDITQATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIG KIKNGHTGLSNGNGIHHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTGSSPEDCCVHCILACLFCEFLTLCN -------------------------------------------------------------- >70585_70585_4_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000449182_MDFIC_chr7_114582330_ENST00000393486_length(transcript)=4357nt_BP=443nt CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGGAAAATG TGATAAAGACAATACTGAGAAAGATATAACTCAAGCTACCAATAGCCACTTCACACATGGAGAGATGCAAGACCAGTCCATTTGGGGAAA TCCTTCGGATGGTGAACTCATTAGAACCCAACCTCAGCGCTTGCCTCAGCTTCAGACTTCAGCCCAGGTGCCAAGTGGTGAGGAAATAGG CAAGATAAAGAACGGCCACACAGGTCTGAGCAATGGAAATGGAATTCACCACGGGGCCAAACACGGATCCGCAGATAATCGCAAACTTTC AGCACCTGTTTCTCAAAAAATGCATAGAAAAATTCAGTCCAGCTTGTCTGTAAACAGCGATATCAGTAAGAAGAGCAAAGTAAATGCTGT CTTTTCCCAAAAGACAGGCTCTTCACCTGAAGATTGTTGTGTCCACTGTATCCTGGCTTGCTTGTTCTGCGAATTCCTGACCCTTTGCAA CATTGTCCTGGGACAAGCGTCATGTGGCATCTGCACCTCAGAAGCCTGCTGCTGTTGCTGTGGTGACGAGATGGGGGATGATTGTAACTG CCCTTGTGATATGGACTGTGGCATCATGGATGCCTGTTGTGAATCATCAGACTGCTTGGAAATCTGTATGGAATGCTGTGGAATTTGTTT TCCTTCATAAATATTTATCTTTTGTTTGTGTTAAAACTGGAGAGTGTTTAAAAATTTCCTTTTGGGGGGAAGAAAAGCACATTGTAAGAT TCTCATGAAACAACATGGAATTTGCACTGTTAACTCATTATTGTAAGTAATCTCTGAAAGCCTTTTTACTTTAACCAAATCTACATGGTT TAATATGTGAAATTTTAACTACTTTAACTAGTTTTATAAATTTCTTAATATGTTACAATAACTTAGGGACATTTTGACACCCCCCTTCCC AAATGTTAAATGCCTTCTCCTTTTTACCGATATTTCTGTTTCTTTTAACCGTTCTCAGGAGCACTTTGCTCCAAATATATTATTTTTCAG TGTGTATTTAAACGAGGCAGTTTATTTTGATATGTATCTATTCATGATTGAAAGGAAGCAGTCTTGGCCAGGCACGGTGGCTTACACCTG TAACCCTGGCATTTTGGGAGGCCAAGGTGGGCAGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCAGGGCAACATGGTGAAACCCCATCT CTACTAAAATACAAAAAGTTAGCTGGGCTTGGCGGTGTGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAAC CCGAGAGGCGGAAGTTGCAGTGAGCCGAGATTGTGCCACTGAACTCCAACCTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCTCT AAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAACAAACCAGTCTTTATTTTAAAAGAAACTTTAGGAAACAAACCCACAT AATAGTTGGGAACCAGTGTTGATCTCTCTCCCTTACCTTCTCCACTTGTTCAACAGACTCTGAATGCCGACTGTGTGGACTCTCTTCCTC AGACTGTGGGGACAGATACAATTCCACTCCTGTCCACAGGAACATGAGATTTAGCAGACTAAGGAGATCTGTAAAGAATGAACCATACCA CAAGGCATACTGAAGTGAGGATTATAAGAGAAATAAACTCAAAATGCTGTTGGAATATGCAGAGAATTGCTACCAGAATATTCAGTAAGG TTTCAGGGAGAATGTGGCATTTGAGGACTCTCTTAGAATGAGTGATTCACCTGCTATTTAAATGAATTATTTAGATTTTTGACAAAGATT TAGGTGGACACCCTAAACTGTGTGTGCCTTTAACCAGTTAAAAGAACAGTGCCTTCAGCATACTTTTTTATTAGTTGTAGGAATACAGCT TTTTGAAAAAGCTATAAAGTTTAAATTAACTAAAAATATGCATTTTCTTACACATAATTTAAATGTTATCATACTTTTTTGATGAAAACA TAATGCCTTAGTAAAATAGCTCTATTTAATAAAGAAGATTGAGTACTCTGACACATTTCATTTAAATTAGGAAATTTTTAATATTAAAAT CCCAGTGTTCTGAGTTATTGAAAGGCTTTCTTTTATTTTGAGAGCTTTAGGTCTTTTTGGGATGAGAACATTTTAGTTGTTTAGTTTGTT TCTTAAGCAGTGCTATTTTTTGTAAACACAGATAAATGGAAACCATTCTTTTCAATGCAGAAGAAATCTAGATATCCCCTACTGTGACCA AATTTCTGTATTACGATTTTATGTTAAATTAAACTAATATGGCAGGTTATAATGATCCTTAAGTGTAAAGAAATCAGTCAATTACAAGAG TAATTGTATAGTTATTGAGACCTATAGTGTGTGGCTTAGATGAAAGGGAGAGTAAATTTTCATACCATGCTCTCTCCTACTCAGTTTGAT CTCTCTAAAATTGTAGTTTGGTTTGATTTAATATAATTCTTAGTAGAAATTTTGAAAGTATGCTTTGGGATTAATAATTATTTTTAATTT TTCTGGCTGAATATCAAATTGATAGTAACAACAGAAGCATAATTTTAGGAAGGCTTTCGCAAACCTAGCCTTTTAAGAGAGGTTTTTAAC CTGAAGCATGAGAATATATCACCTGTGGTTTTTCCTTTGAGATGAAACGTAGTTTCTAGTTATATCATTACTTAAAGGGCTTAAAAAGAA AAAACTTAGCAAACTTTTGAATCTTTCTTTTATTGCTATTTACACATACATACACACATACAAAACCTTTAAATTTTGGGATCTGAATAT AATTCTGGTAAACAGCTGTCTTCATTTTTCTCCTCTAAAGAACTTAATTCATTTGTTACATAAAATATAAGGAAATCTTTATACTATTTT ACAGTAACCACAATCTAAATATTTACATATACCCAAAATTAACTTATGCTCATATATTAGGATGTGAGAATATCATCTGTTTATGGACAC ATGAAACCTCCTAATGACCTGGAATTGTTAGAATATTTGACTTTTTATATGCAAAGTTTTTCAACCAAGTGGTTTGTCTAATATTTAAAC ATGTACTGGCACAATTTGTGATGAAAATATTAGCACATTTGCAATAATGTTTCTCCATAACAGAGAATGTTAATGGATACCAGAATTTTA TTTTTGTATTTATGTTCATAGTACTTTTCCTCTTGTCTACTCCAGACAGTTATTCCATAAAGCATTTGTATAATTAAAAGGAAAACAGAA AAAGGAAAAGTAGGCAAATGTGAAAATAGTTTCAATATATCTTATGATTTCTTAATGTAAAATGTTTTGTTGAAGTATATGGCTATCATG ACTAAGTGCTAGAATTTATAGTTACAGGCGGTGTCCTTTTAAATGTGGAAAGGCTTTTAAAATATTTTAAAACTGGACCTGTATTATCCT GAATACACTATTTTGAAAATTTTTAAAAATGACTTCTTTATTTTGCTTTACCGTATGTTTATATCTAATTGACATATTGACTAATGTTTG AAAGAATTCAACCATAAGTTAAAATCTGAAGGTTATCTTTATCATGTTTCATCCCTGTCTGAAGATTTCCTAGTCTTCTTATGTAAATCA CATGACTCATGTCCGTAAATGAACTATGAAAGATATCGATCAGTTTATGATCATTGACATGTGATTTCAAAACACAGTGTTCTTTTAAAA ATCTATAATATGTCAAAATACAAGTTTTTTTTTTTTACATCGTTTTAGTAAGTTAATTTCATTTATTTACTTTGGAGCTATATTTCCACT TAGAAAAACTAAGGTAATTTTACAATATATGCTGAGATTAAAAACCAAGGTAAAAATGATCAAACATATATGAAATTGAGTCTTAGATTT >70585_70585_4_PTPRZ1-MDFIC_PTPRZ1_chr7_121608184_ENST00000449182_MDFIC_chr7_114582330_ENST00000393486_length(amino acids)=332AA_BP=117 MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN VNLKKLKFQGWDKTSLENTFIHNTGKTGKCDKDNTEKDITQATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIG KIKNGHTGLSNGNGIHHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNAVFSQKTGSSPEDCCVHCILACLFCEFLTLCN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PTPRZ1-MDFIC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PTPRZ1-MDFIC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PTPRZ1-MDFIC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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