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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PTPRZ1-TSPAN33 (FusionGDB2 ID:70593) |
Fusion Gene Summary for PTPRZ1-TSPAN33 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPRZ1-TSPAN33 | Fusion gene ID: 70593 | Hgene | Tgene | Gene symbol | PTPRZ1 | TSPAN33 | Gene ID | 5803 | 340348 |
| Gene name | protein tyrosine phosphatase receptor type Z1 | tetraspanin 33 | |
| Synonyms | HPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan | PEN|PEN.|TSPAN-33 | |
| Cytomap | 7q31.32 | 7q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine | tetraspanin-33penumbraproerythroblast new membrane | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000393386, ENST00000449182, ENST00000483028, | ENST00000289407, | |
| Fusion gene scores | * DoF score | 15 X 14 X 7=1470 | 3 X 1 X 3=9 |
| # samples | 19 | 3 | |
| ** MAII score | log2(19/1470*10)=-2.95174483139278 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PTPRZ1 [Title/Abstract] AND TSPAN33 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PTPRZ1(121695141)-TSPAN33(128801520), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TSPAN33 | GO:0051604 | protein maturation | 23091066 |
| Tgene | TSPAN33 | GO:0072659 | protein localization to plasma membrane | 23091066 |
| Fusion gene breakpoints across PTPRZ1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TSPAN33 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CV-5434-01A | PTPRZ1 | chr7 | 121695141 | - | TSPAN33 | chr7 | 128801520 | + |
| ChimerDB4 | HNSC | TCGA-CV-5434-01A | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + |
| ChimerDB4 | HNSC | TCGA-CV-5434 | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + |
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Fusion Gene ORF analysis for PTPRZ1-TSPAN33 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393386 | ENST00000289407 | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + |
| In-frame | ENST00000449182 | ENST00000289407 | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + |
| intron-3CDS | ENST00000483028 | ENST00000289407 | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393386 | PTPRZ1 | chr7 | 121695141 | + | ENST00000289407 | TSPAN33 | chr7 | 128801520 | + | 8611 | 6939 | 192 | 7688 | 2498 |
| ENST00000449182 | PTPRZ1 | chr7 | 121695141 | + | ENST00000289407 | TSPAN33 | chr7 | 128801520 | + | 5738 | 4066 | 91 | 4815 | 1574 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393386 | ENST00000289407 | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + | 0.000233212 | 0.99976677 |
| ENST00000449182 | ENST00000289407 | PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801520 | + | 0.00054614 | 0.99945384 |
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Fusion Genomic Features for PTPRZ1-TSPAN33 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801519 | + | 3.31E-05 | 0.99996686 |
| PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801519 | + | 3.31E-05 | 0.99996686 |
| PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801519 | + | 3.31E-05 | 0.99996686 |
| PTPRZ1 | chr7 | 121695141 | + | TSPAN33 | chr7 | 128801519 | + | 3.31E-05 | 0.99996686 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PTPRZ1-TSPAN33 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:121695141/chr7:128801520) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 1717_1992 | 2176 | 2316.0 | Domain | Tyrosine-protein phosphatase 1 |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 314_413 | 2176 | 2316.0 | Domain | Fibronectin type-III |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 36_300 | 2176 | 2316.0 | Domain | Alpha-carbonic anhydrase |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 1933_1939 | 2176 | 2316.0 | Region | Substrate binding |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 25_1636 | 2176 | 2316.0 | Topological domain | Extracellular |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 1637_1662 | 2176 | 2316.0 | Transmembrane | Helical |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 118_235 | 34 | 284.0 | Topological domain | Extracellular | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 257_283 | 34 | 284.0 | Topological domain | Cytoplasmic | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 46_64 | 34 | 284.0 | Topological domain | Extracellular | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 86_96 | 34 | 284.0 | Topological domain | Cytoplasmic | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 236_256 | 34 | 284.0 | Transmembrane | Helical | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 65_85 | 34 | 284.0 | Transmembrane | Helical | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 97_117 | 34 | 284.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 2023_2282 | 2176 | 2316.0 | Domain | Tyrosine-protein phosphatase 2 |
| Hgene | PTPRZ1 | chr7:121695141 | chr7:128801520 | ENST00000393386 | + | 27 | 30 | 1663_2315 | 2176 | 2316.0 | Topological domain | Cytoplasmic |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 1_24 | 34 | 284.0 | Topological domain | Cytoplasmic | |
| Tgene | TSPAN33 | chr7:121695141 | chr7:128801520 | ENST00000289407 | 0 | 8 | 25_45 | 34 | 284.0 | Transmembrane | Helical |
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Fusion Gene Sequence for PTPRZ1-TSPAN33 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >70593_70593_1_PTPRZ1-TSPAN33_PTPRZ1_chr7_121695141_ENST00000393386_TSPAN33_chr7_128801520_ENST00000289407_length(transcript)=8611nt_BP=6939nt AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAA ATTAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGC AATATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTT TCAAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTC AAAGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAAC TCAACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTT AGCATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAAC AATTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCA GAACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATT GAGAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCT ATTCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAA CTGATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAG GGAAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACC ACAACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGT GATGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTG ACTGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTG TCGGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCT GAAGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAAC CCAGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTA AAGGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTT CTCCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCC TCAGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGA CAACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGGTGAGACACCTCTTCAACCTTCCTAC AGTAGTGAAGTCTTTCCTCTAGTCACCCCTTTGTTGCTTGACAATCAGATCCTCAACACTACCCCTGCTGCTTCAAGTAGTGATTCGGCC TTGCATGCTACGCCTGTATTTCCCAGTGTCGATGTGTCATTTGAATCCATCCTGTCTTCCTATGATGGTGCACCTTTGCTTCCATTTTCC TCTGCTTCCTTCAGTAGTGAATTGTTTCGCCATCTGCATACAGTTTCTCAAATCCTTCCACAAGTTACTTCAGCTACCGAGAGTGATAAG GTGCCCTTGCATGCTTCTCTGCCAGTGGCTGGGGGTGATTTGCTATTAGAGCCCAGCCTTGCTCAGTATTCTGATGTGCTGTCCACTACT CATGCTGCTTCAGAGACGCTGGAATTTGGTAGTGAATCTGGTGTTCTTTATAAAACGCTTATGTTTTCTCAAGTTGAACCACCCAGCAGT GATGCCATGATGCATGCACGTTCTTCAGGGCCTGAACCTTCTTATGCCTTGTCTGATAATGAGGGCTCCCAACACATCTTCACTGTTTCT TACAGTTCTGCAATACCTGTGCATGATTCTGTGGGTGTAACTTATCAGGGTTCCTTATTTAGCGGCCCTAGCCATATACCAATACCTAAG TCTTCGTTAATAACCCCAACTGCATCATTACTGCAGCCTACTCATGCCCTCTCTGGTGATGGGGAATGGTCTGGAGCCTCTTCTGATAGT GAATTTCTTTTACCTGACACAGATGGGCTGACAGCCCTTAACATTTCTTCACCTGTTTCTGTAGCTGAATTTACATATACAACATCTGTG TTTGGTGATGATAATAAGGCGCTTTCTAAAAGTGAAATAATATATGGAAATGAGACTGAACTGCAAATTCCTTCTTTCAATGAGATGGTT TACCCTTCTGAAAGCACAGTCATGCCCAACATGTATGATAATGTAAATAAGTTGAATGCGTCTTTACAAGAAACCTCTGTTTCCATTTCT AGCACCAAGGGCATGTTTCCAGGGTCCCTTGCTCATACCACCACTAAGGTTTTTGATCATGAGATTAGTCAAGTTCCAGAAAATAACTTT TCAGTTCAACCTACACATACTGTCTCTCAAGCATCTGGTGACACTTCGCTTAAACCTGTGCTTAGTGCAAACTCAGAGCCAGCATCCTCT GACCCTGCTTCTAGTGAAATGTTATCTCCTTCAACTCAGCTCTTATTTTATGAGACCTCAGCTTCTTTTAGTACTGAAGTATTGCTACAA CCTTCCTTTCAGGCTTCTGATGTTGACACCTTGCTTAAAACTGTTCTTCCAGCTGTGCCCAGTGATCCAATATTGGTTGAAACCCCCAAA GTTGATAAAATTAGTTCTACAATGTTGCATCTCATTGTATCAAATTCTGCTTCAAGTGAAAACATGCTGCACTCTACATCTGTACCAGTT TTTGATGTGTCGCCTACTTCTCATATGCACTCTGCTTCACTTCAAGGTTTGACCATTTCCTATGCAAGTGAGAAATATGAACCAGTTTTG TTAAAAAGTGAAAGTTCCCACCAAGTGGTACCTTCTTTGTACAGTAATGATGAGTTGTTCCAAACGGCCAATTTGGAGATTAACCAGGCC CATCCCCCAAAAGGAAGGCATGTATTTGCTACACCTGTTTTATCAATTGATGAACCATTAAATACACTAATAAATAAGCTTATACATTCC GATGAAATTTTAACCTCCACCAAAAGTTCTGTTACTGGTAAGGTATTTGCTGGTATTCCAACAGTTGCTTCTGATACATTTGTATCTACT GATCATTCTGTTCCTATAGGAAATGGGCATGTTGCCATTACAGCTGTTTCTCCCCACAGAGATGGTTCTGTAACCTCAACAAAGTTGCTG TTTCCTTCTAAGGCAACTTCTGAGCTGAGTCATAGTGCCAAATCTGATGCCGGTTTAGTGGGTGGTGGTGAAGATGGTGACACTGATGAT GATGGTGATGATGATGATGATGACAGAGGTAGTGATGGCTTATCCATTCATAAGTGTATGTCATGCTCATCCTATAGAGAATCACAGGAA AAGGTAATGAATGATTCAGACACCCACGAAAACAGTCTTATGGATCAGAATAATCCAATCTCATACTCACTATCTGAGAATTCTGAAGAA GATAATAGAGTCACAAGTGTATCCTCAGACAGTCAAACTGGTATGGACAGAAGTCCTGGTAAATCACCATCAGCAAATGGGCTATCCCAA AAGCACAATGATGGAAAAGAGGAAAATGACATTCAGACTGGTAGTGCTCTGCTTCCTCTCAGCCCTGAATCTAAAGCATGGGCAGTTCTG ACAAGTGATGAAGAAAGTGGATCAGGGCAAGGTACCTCAGATAGCCTTAATGAGAATGAGACTTCCACAGATTTCAGTTTTGCAGACACT AATGAAAAAGATGCTGATGGGATCCTGGCAGCAGGTGACTCAGAAATAACTCCTGGATTCCCACAGTCCCCAACATCATCTGTTACTAGC GAGAACTCAGAAGTGTTCCACGTTTCAGAGGCAGAGGCCAGTAATAGTAGCCATGAGTCTCGTATTGGTCTAGCTGAGGGGTTGGAATCC GAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGTTCTTGTGGGTATTCTCATCTACTGGAGG AAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCACACCTCCAACACCTATCTTTCCAATTTCA GATGATGTCGGAGCAATTCCAATAAAGCACTTTCCAAAGCATGTTGCAGATTTACATGCAAGTAGTGGGTTTACTGAAGAATTTGAGACA CTGAAAGAGTTTTACCAGGAAGTGCAGAGCTGTACTGTTGACTTAGGTATTACAGCAGACAGCTCCAACCACCCAGACAACAAGCACAAG AATCGATACATAAATATCGTTGCCTATGATCATAGCAGGGTTAAGCTAGCACAGCTTGCTGAAAAGGATGGCAAACTGACTGATTATATC AATGCCAATTATGTTGATGGCTACAACAGACCAAAAGCTTATATTGCTGCCCAAGGCCCACTGAAATCCACAGCTGAAGATTTCTGGAGA ATGATATGGGAACATAATGTGGAAGTTATTGTCATGATAACAAACCTCGTGGAGAAAGGAAGGAGAAAATGTGATCAGTACTGGCCTGCC GATGGGAGTGAGGAGTACGGGAACTTTCTGGTCACTCAGAAGAGTGTGCAAGTGCTTGCCTATTATACTGTGAGGAATTTTACTCTAAGA AACACAAAAATAAAAAAGGGCTCCCAGAAAGGAAGACCCAGTGGACGTGTGGTCACACAGTATCACTACACGCAGTGGCCTGACATGGGA GTACCAGAGTACTCCCTGCCAGTGCTGACCTTTGTGAGAAAGGCAGCCTATGCCAAGCGCCATGCAGTGGGGCCTGTTGTCGTCCACTGC AGTGCTGGAGTTGGAAGAACAGGCACATATATTGTGCTAGACAGTATGTTGCAGCAGATTCAACACGAAGGAACTGTCAACATATTTGGC TTCTTAAAACACATCCGTTCACAAAGAAATTATTTGGTACAAACTGAGGAGCAATATGTCTTCATTCATGATACACTGGTTGAGGCCATA CTTAGTAAAGAAACTGAGGTGCTGGACAGTCATATTCATGCCTATGTTAATGCACTCCTCATTCCTGGACCAGCAGGCAAAACAAAGCTA GAGAAACAATTCCAGCTCCTGAGCCAGTCAAATATACAGCAGAGTGACTATTCTGCAGCCCTAAAGCAATGCAACAGGGAAAAGAATCGA ACTTCTTCTATCATCCCTGTGGAAAGATCAAGGGTTGGCATTTCATCCCTGAGTGGAGAAGGCACAGACTACATCAATGCCTCCTATATC ATGGGCTATTACCAGAGCAATGAATTCATCATTACCCAGCACCCTCTCCTTCATACCATCAAGGATTTCTGGAGGATGATATGGGACCAT AATGCCCAACTGGTGGTTATGATTCCTGATGGCCAAAACATGGCAGAAGATGAATTTGTTTACTGGCCAAATAAAGATGAGCCTATAAAT TGTGAGAGCTTTAAGGTCACTCTTATGGCTGAAGAACACAAATGTCTATCTAATGAGGAAAAACTTATAATTCAGGACTTTATCTTAGAA GCTACACAGGTGATTTCCATGGTGATGGTGGCTGTGGGTGTCTACGCTCGGCTAATGAAGCATGCAGAAGCAGCCCTAGCCTGCCTGGCA GTGGACCCTGCCATCCTGCTGATCGTGGTGGGTGTCCTCATGTTCCTGCTCACCTTCTGTGGCTGCATTGGGTCCCTCCGCGAGAACATC TGCCTCCTGCAGACGTTCTCCCTCTGCCTCACCGCTGTGTTCCTGCTGCAGCTGGCCGCTGGGATCCTGGGCTTCGTCTTCTCAGACAAG GCTCGAGGGAAAGTGAGTGAGATCATCAACAATGCCATTGTGCACTACCGAGATGACTTGGATCTGCAGAACCTCATTGATTTTGGCCAG AAAAAGTTTAGCTGCTGTGGAGGGATTTCCTACAAGGACTGGTCTCAGAACATGTATTTCAACTGCTCAGAAGACAACCCCAGTCGAGAG CGCTGCTCTGTGCCTTACTCCTGTTGCTTGCCTACTCCTGACCAGGCAGTGATCAACACTATGTGTGGCCAAGGTATGCAGGCCTTTGAC TACTTGGAAGCTAGCAAAGTCATCTACACCAATGGCTGTATTGACAAGTTGGTCAACTGGATACACAGCAACCTATTCTTACTTGGTGGT GTGGCTCTAGGCCTGGCCATCCCCCAGCTGGTGGGAATTCTGCTGTCCCAGATCCTAGTGAATCAGATCAAAGATCAGATCAAGCTACAG CTCTACAACCAGCAGCACCGGGCTGACCCATGGTACTGAGAATCCATCCTGCACCTCCTCACCATGGAAACTGGCAAGCCTCATAAACGA ACAGCAGTGGGTGCTGAAAGCAGCACCAAATGGAGATTTGGATTCCAGCCCCCCAGTGACAGCCCAGTGGGAAGAAGCAAACTCCAGATG GGCAGAAGGCAGGGTGCACAGGTGGCTCCAGTCTCAGGAGGATGCGCCTCCTCTCCCCCATCCCAGCCCTCAGCATTGTGCCAGAGTGAT ACCCTTAAGTGTTTGGGTTTATGTTTTCAGTTTTGTTTGGGAAACAGCAGTTGCACAGAGAGTTGGGGGTACTGCTGCTGCCTTTTCACC GAGGCACTGCCACCACCAGCTCTAGCAGGGATGCTCCTGAGCTTGGCGGACATACTTAGATCCTAACGTGCCAGTGAGACCTGGCTGTGG AGAGTAGCACTGGCAGCCCTGCCTGGACTCCACTTGGCATGATACCAGCTCCAGAAGGGAAGGGAGTGGAGCAGGCAGTGAGGAGAGAGC CTGGGGGTCGGCTGGGGACAGCCGTATGTGCTAGGTAGGAGTGGAGGGAGATATGTTTACCAAATGCCTGTCCTGCCATCCTCCCAGGTA GTCAGAGTGAGCTACATCCTGCCCCGCCTTCATTTCCATGGAAACATGGCAGCTAGGACACGGGGTACAACAGCAGCCAAATTCTTCCCC ACCTCCCTTACTTCGAAAAAAAGTTTGGAACCCTGGTCCCTATACTCTGCAGTCAGAAGTGGGACTGAGCCATACATGCCCTTGAATTCC TCCCTGTCTGGCCCTCCCTCTCCAGCAAGCAGGGTTTTCTTTAACTTGGCAGTGTGCAGAGGAGAAGTGGTAACACCCCCACCCCATTCC >70593_70593_1_PTPRZ1-TSPAN33_PTPRZ1_chr7_121695141_ENST00000393386_TSPAN33_chr7_128801520_ENST00000289407_length(amino acids)=2498AA_BP=2 MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLT NDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAII DGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFRE QQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNN LLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHY NRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTA ESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPS MEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDL VSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASF SSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMM HARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLL PDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKG MFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQ ASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSE SSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSV PIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMN DSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDE ESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWE HNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEY SLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE TEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYY QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQV ISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGK VSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEA -------------------------------------------------------------- >70593_70593_2_PTPRZ1-TSPAN33_PTPRZ1_chr7_121695141_ENST00000449182_TSPAN33_chr7_128801520_ENST00000289407_length(transcript)=5738nt_BP=4066nt CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAAAT TAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGCAA TATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTTTC AAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTCAA AGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAACTC AACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTTAG CATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAACAA TTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCAGA ACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATTGA GAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCTAT TCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAACT GATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAGGG AAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACCAC AACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGTGA TGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTGAC TGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTGTC GGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCTGA AGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAACCC AGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTAAA GGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTTCT CCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCCTC AGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGACA ACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGAGGCCAGTAATAGTAGCCATGAGTCTCG TATTGGTCTAGCTGAGGGGTTGGAATCCGAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGT TCTTGTGGGTATTCTCATCTACTGGAGGAAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCAC ACCTCCAACACCTATCTTTCCAATTTCAGATGATGTCGGAGCAATTCCAATAAAGCACTTTCCAAAGCATGTTGCAGATTTACATGCAAG TAGTGGGTTTACTGAAGAATTTGAGGAAGTGCAGAGCTGTACTGTTGACTTAGGTATTACAGCAGACAGCTCCAACCACCCAGACAACAA GCACAAGAATCGATACATAAATATCGTTGCCTATGATCATAGCAGGGTTAAGCTAGCACAGCTTGCTGAAAAGGATGGCAAACTGACTGA TTATATCAATGCCAATTATGTTGATGGCTACAACAGACCAAAAGCTTATATTGCTGCCCAAGGCCCACTGAAATCCACAGCTGAAGATTT CTGGAGAATGATATGGGAACATAATGTGGAAGTTATTGTCATGATAACAAACCTCGTGGAGAAAGGAAGGAGAAAATGTGATCAGTACTG GCCTGCCGATGGGAGTGAGGAGTACGGGAACTTTCTGGTCACTCAGAAGAGTGTGCAAGTGCTTGCCTATTATACTGTGAGGAATTTTAC TCTAAGAAACACAAAAATAAAAAAGGGCTCCCAGAAAGGAAGACCCAGTGGACGTGTGGTCACACAGTATCACTACACGCAGTGGCCTGA CATGGGAGTACCAGAGTACTCCCTGCCAGTGCTGACCTTTGTGAGAAAGGCAGCCTATGCCAAGCGCCATGCAGTGGGGCCTGTTGTCGT CCACTGCAGTGCTGGAGTTGGAAGAACAGGCACATATATTGTGCTAGACAGTATGTTGCAGCAGATTCAACACGAAGGAACTGTCAACAT ATTTGGCTTCTTAAAACACATCCGTTCACAAAGAAATTATTTGGTACAAACTGAGGAGCAATATGTCTTCATTCATGATACACTGGTTGA GGCCATACTTAGTAAAGAAACTGAGGTGCTGGACAGTCATATTCATGCCTATGTTAATGCACTCCTCATTCCTGGACCAGCAGGCAAAAC AAAGCTAGAGAAACAATTCCAGCTCCTGAGCCAGTCAAATATACAGCAGAGTGACTATTCTGCAGCCCTAAAGCAATGCAACAGGGAAAA GAATCGAACTTCTTCTATCATCCCTGTGGAAAGATCAAGGGTTGGCATTTCATCCCTGAGTGGAGAAGGCACAGACTACATCAATGCCTC CTATATCATGGGCTATTACCAGAGCAATGAATTCATCATTACCCAGCACCCTCTCCTTCATACCATCAAGGATTTCTGGAGGATGATATG GGACCATAATGCCCAACTGGTGGTTATGATTCCTGATGGCCAAAACATGGCAGAAGATGAATTTGTTTACTGGCCAAATAAAGATGAGCC TATAAATTGTGAGAGCTTTAAGGTCACTCTTATGGCTGAAGAACACAAATGTCTATCTAATGAGGAAAAACTTATAATTCAGGACTTTAT CTTAGAAGCTACACAGGTGATTTCCATGGTGATGGTGGCTGTGGGTGTCTACGCTCGGCTAATGAAGCATGCAGAAGCAGCCCTAGCCTG CCTGGCAGTGGACCCTGCCATCCTGCTGATCGTGGTGGGTGTCCTCATGTTCCTGCTCACCTTCTGTGGCTGCATTGGGTCCCTCCGCGA GAACATCTGCCTCCTGCAGACGTTCTCCCTCTGCCTCACCGCTGTGTTCCTGCTGCAGCTGGCCGCTGGGATCCTGGGCTTCGTCTTCTC AGACAAGGCTCGAGGGAAAGTGAGTGAGATCATCAACAATGCCATTGTGCACTACCGAGATGACTTGGATCTGCAGAACCTCATTGATTT TGGCCAGAAAAAGTTTAGCTGCTGTGGAGGGATTTCCTACAAGGACTGGTCTCAGAACATGTATTTCAACTGCTCAGAAGACAACCCCAG TCGAGAGCGCTGCTCTGTGCCTTACTCCTGTTGCTTGCCTACTCCTGACCAGGCAGTGATCAACACTATGTGTGGCCAAGGTATGCAGGC CTTTGACTACTTGGAAGCTAGCAAAGTCATCTACACCAATGGCTGTATTGACAAGTTGGTCAACTGGATACACAGCAACCTATTCTTACT TGGTGGTGTGGCTCTAGGCCTGGCCATCCCCCAGCTGGTGGGAATTCTGCTGTCCCAGATCCTAGTGAATCAGATCAAAGATCAGATCAA GCTACAGCTCTACAACCAGCAGCACCGGGCTGACCCATGGTACTGAGAATCCATCCTGCACCTCCTCACCATGGAAACTGGCAAGCCTCA TAAACGAACAGCAGTGGGTGCTGAAAGCAGCACCAAATGGAGATTTGGATTCCAGCCCCCCAGTGACAGCCCAGTGGGAAGAAGCAAACT CCAGATGGGCAGAAGGCAGGGTGCACAGGTGGCTCCAGTCTCAGGAGGATGCGCCTCCTCTCCCCCATCCCAGCCCTCAGCATTGTGCCA GAGTGATACCCTTAAGTGTTTGGGTTTATGTTTTCAGTTTTGTTTGGGAAACAGCAGTTGCACAGAGAGTTGGGGGTACTGCTGCTGCCT TTTCACCGAGGCACTGCCACCACCAGCTCTAGCAGGGATGCTCCTGAGCTTGGCGGACATACTTAGATCCTAACGTGCCAGTGAGACCTG GCTGTGGAGAGTAGCACTGGCAGCCCTGCCTGGACTCCACTTGGCATGATACCAGCTCCAGAAGGGAAGGGAGTGGAGCAGGCAGTGAGG AGAGAGCCTGGGGGTCGGCTGGGGACAGCCGTATGTGCTAGGTAGGAGTGGAGGGAGATATGTTTACCAAATGCCTGTCCTGCCATCCTC CCAGGTAGTCAGAGTGAGCTACATCCTGCCCCGCCTTCATTTCCATGGAAACATGGCAGCTAGGACACGGGGTACAACAGCAGCCAAATT CTTCCCCACCTCCCTTACTTCGAAAAAAAGTTTGGAACCCTGGTCCCTATACTCTGCAGTCAGAAGTGGGACTGAGCCATACATGCCCTT GAATTCCTCCCTGTCTGGCCCTCCCTCTCCAGCAAGCAGGGTTTTCTTTAACTTGGCAGTGTGCAGAGGAGAAGTGGTAACACCCCCACC >70593_70593_2_PTPRZ1-TSPAN33_PTPRZ1_chr7_121695141_ENST00000449182_TSPAN33_chr7_128801520_ENST00000289407_length(amino acids)=1574AA_BP=1324 MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN VNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFS SFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVS ISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIE KFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEG KDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVT ELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENP ETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPS VTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVV LVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEEVQSCTVDLGITADSSNHPDNK HKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYW PADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVV HCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKT KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIW DHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQVISMVMVAVGVYARLMKHAEAALAC LAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDF GQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PTPRZ1-TSPAN33 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PTPRZ1-TSPAN33 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PTPRZ1-TSPAN33 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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