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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PTPRZ1-UBE2H (FusionGDB2 ID:70594)

Fusion Gene Summary for PTPRZ1-UBE2H

Fusion gene summary

Fusion gene information	Fusion gene name: PTPRZ1-UBE2H
	Fusion gene ID: 70594
		Hgene	Tgene
	Gene symbol	PTPRZ1	UBE2H
	Gene ID	5803	7328
	Gene name	protein tyrosine phosphatase receptor type Z1	ubiquitin conjugating enzyme E2 H
	Synonyms	HPTPZ\|HPTPzeta\|PTP-ZETA\|PTP18\|PTPRZ\|PTPZ\|R-PTP-zeta-2\|RPTPB\|RPTPbeta\|phosphacan	E2-20K\|GID3\|UBC8\|UBCH\|UBCH2
	Cytomap	7q31.32	7q32.2
	Type of gene	protein-coding	protein-coding
	Description	receptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine	ubiquitin-conjugating enzyme E2 H(E3-independent) E2 ubiquitin-conjugating enzyme HE2 ubiquitin-conjugating enzyme HGID complex subunit 3, UBC8 homologubiquitin carrier protein Hubiquitin conjugating enzyme E2Hubiquitin-conjugating enzyme E2-20Kubi
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000393386, ENST00000449182, ENST00000483028,	ENST00000355621, ENST00000473814,
Fusion gene scores	* DoF score	15 X 14 X 7=1470	12 X 10 X 7=840
	# samples	19	14
	** MAII score	log2(19/1470*10)=-2.95174483139278 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/840*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTPRZ1 [Title/Abstract] AND UBE2H [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PTPRZ1(121668697)-UBE2H(129479175), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UBE2H	GO:0070936	protein K48-linked ubiquitination	20061386
Tgene	UBE2H	GO:0070979	protein K11-linked ubiquitination	20061386

Fusion gene breakpoints across PTPRZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBE2H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A8OQ-01A	PTPRZ1	chr7	121668697	-	UBE2H	chr7	129479175	-
ChimerDB4	BRCA	TCGA-AC-A8OQ-01A	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-

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Fusion Gene ORF analysis for PTPRZ1-UBE2H

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000393386	ENST00000355621	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-
In-frame	ENST00000393386	ENST00000473814	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-
In-frame	ENST00000449182	ENST00000355621	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-
In-frame	ENST00000449182	ENST00000473814	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-
intron-3CDS	ENST00000483028	ENST00000355621	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-
intron-3CDS	ENST00000483028	ENST00000473814	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393386	PTPRZ1	chr7	121668697	+	ENST00000355621	UBE2H	chr7	129479175	-	9950	5491	192	5744	1850
ENST00000393386	PTPRZ1	chr7	121668697	+	ENST00000473814	UBE2H	chr7	129479175	-	5745	5491	192	5744	1850
ENST00000449182	PTPRZ1	chr7	121668697	+	ENST00000355621	UBE2H	chr7	129479175	-	7098	2639	91	2892	933
ENST00000449182	PTPRZ1	chr7	121668697	+	ENST00000473814	UBE2H	chr7	129479175	-	2893	2639	91	2892	934

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393386	ENST00000355621	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-	0.000440579	0.99955946
ENST00000393386	ENST00000473814	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-	0.000593874	0.9994061
ENST00000449182	ENST00000355621	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-	0.000113017	0.999887
ENST00000449182	ENST00000473814	PTPRZ1	chr7	121668697	+	UBE2H	chr7	129479175	-	0.000277342	0.99972266

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Fusion Genomic Features for PTPRZ1-UBE2H

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRZ1-UBE2H

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:121668697/chr7:129479175)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

314_413

1693

2316.0

Domain

Fibronectin type-III

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

36_300

1693

2316.0

Domain

Alpha-carbonic anhydrase

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

25_1636

1693

2316.0

Topological domain

Extracellular

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

1637_1662

1693

2316.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

1717_1992

1693

2316.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

2023_2282

1693

2316.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

1933_1939

1693

2316.0

Region

Substrate binding

Hgene

PTPRZ1

chr7:121668697

chr7:129479175

ENST00000393386

1663_2315

1693

2316.0

Topological domain

Cytoplasmic

Tgene

UBE2H

chr7:121668697

chr7:129479175

ENST00000355621

1_150

184.0

Domain

UBC core

Tgene

UBE2H

chr7:121668697

chr7:129479175

ENST00000473814

1_150

153.0

Domain

UBC core

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Fusion Gene Sequence for PTPRZ1-UBE2H

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>70594_70594_1_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000393386_UBE2H_chr7_129479175_ENST00000355621_length(transcript)=9950nt_BP=5491nt
AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG
CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT
ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA
TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC
ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC
CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA
CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA
AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAA
ATTAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGC
AATATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTT
TCAAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTC
AAAGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAAC
TCAACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTT
AGCATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAAC
AATTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCA
GAACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATT
GAGAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCT
ATTCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAA
CTGATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAG
GGAAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACC
ACAACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGT
GATGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTG
ACTGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTG
TCGGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCT
GAAGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAAC
CCAGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTA
AAGGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTT
CTCCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCC
TCAGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGA
CAACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGGTGAGACACCTCTTCAACCTTCCTAC
AGTAGTGAAGTCTTTCCTCTAGTCACCCCTTTGTTGCTTGACAATCAGATCCTCAACACTACCCCTGCTGCTTCAAGTAGTGATTCGGCC
TTGCATGCTACGCCTGTATTTCCCAGTGTCGATGTGTCATTTGAATCCATCCTGTCTTCCTATGATGGTGCACCTTTGCTTCCATTTTCC
TCTGCTTCCTTCAGTAGTGAATTGTTTCGCCATCTGCATACAGTTTCTCAAATCCTTCCACAAGTTACTTCAGCTACCGAGAGTGATAAG
GTGCCCTTGCATGCTTCTCTGCCAGTGGCTGGGGGTGATTTGCTATTAGAGCCCAGCCTTGCTCAGTATTCTGATGTGCTGTCCACTACT
CATGCTGCTTCAGAGACGCTGGAATTTGGTAGTGAATCTGGTGTTCTTTATAAAACGCTTATGTTTTCTCAAGTTGAACCACCCAGCAGT
GATGCCATGATGCATGCACGTTCTTCAGGGCCTGAACCTTCTTATGCCTTGTCTGATAATGAGGGCTCCCAACACATCTTCACTGTTTCT
TACAGTTCTGCAATACCTGTGCATGATTCTGTGGGTGTAACTTATCAGGGTTCCTTATTTAGCGGCCCTAGCCATATACCAATACCTAAG
TCTTCGTTAATAACCCCAACTGCATCATTACTGCAGCCTACTCATGCCCTCTCTGGTGATGGGGAATGGTCTGGAGCCTCTTCTGATAGT
GAATTTCTTTTACCTGACACAGATGGGCTGACAGCCCTTAACATTTCTTCACCTGTTTCTGTAGCTGAATTTACATATACAACATCTGTG
TTTGGTGATGATAATAAGGCGCTTTCTAAAAGTGAAATAATATATGGAAATGAGACTGAACTGCAAATTCCTTCTTTCAATGAGATGGTT
TACCCTTCTGAAAGCACAGTCATGCCCAACATGTATGATAATGTAAATAAGTTGAATGCGTCTTTACAAGAAACCTCTGTTTCCATTTCT
AGCACCAAGGGCATGTTTCCAGGGTCCCTTGCTCATACCACCACTAAGGTTTTTGATCATGAGATTAGTCAAGTTCCAGAAAATAACTTT
TCAGTTCAACCTACACATACTGTCTCTCAAGCATCTGGTGACACTTCGCTTAAACCTGTGCTTAGTGCAAACTCAGAGCCAGCATCCTCT
GACCCTGCTTCTAGTGAAATGTTATCTCCTTCAACTCAGCTCTTATTTTATGAGACCTCAGCTTCTTTTAGTACTGAAGTATTGCTACAA
CCTTCCTTTCAGGCTTCTGATGTTGACACCTTGCTTAAAACTGTTCTTCCAGCTGTGCCCAGTGATCCAATATTGGTTGAAACCCCCAAA
GTTGATAAAATTAGTTCTACAATGTTGCATCTCATTGTATCAAATTCTGCTTCAAGTGAAAACATGCTGCACTCTACATCTGTACCAGTT
TTTGATGTGTCGCCTACTTCTCATATGCACTCTGCTTCACTTCAAGGTTTGACCATTTCCTATGCAAGTGAGAAATATGAACCAGTTTTG
TTAAAAAGTGAAAGTTCCCACCAAGTGGTACCTTCTTTGTACAGTAATGATGAGTTGTTCCAAACGGCCAATTTGGAGATTAACCAGGCC
CATCCCCCAAAAGGAAGGCATGTATTTGCTACACCTGTTTTATCAATTGATGAACCATTAAATACACTAATAAATAAGCTTATACATTCC
GATGAAATTTTAACCTCCACCAAAAGTTCTGTTACTGGTAAGGTATTTGCTGGTATTCCAACAGTTGCTTCTGATACATTTGTATCTACT
GATCATTCTGTTCCTATAGGAAATGGGCATGTTGCCATTACAGCTGTTTCTCCCCACAGAGATGGTTCTGTAACCTCAACAAAGTTGCTG
TTTCCTTCTAAGGCAACTTCTGAGCTGAGTCATAGTGCCAAATCTGATGCCGGTTTAGTGGGTGGTGGTGAAGATGGTGACACTGATGAT
GATGGTGATGATGATGATGATGACAGAGGTAGTGATGGCTTATCCATTCATAAGTGTATGTCATGCTCATCCTATAGAGAATCACAGGAA
AAGGTAATGAATGATTCAGACACCCACGAAAACAGTCTTATGGATCAGAATAATCCAATCTCATACTCACTATCTGAGAATTCTGAAGAA
GATAATAGAGTCACAAGTGTATCCTCAGACAGTCAAACTGGTATGGACAGAAGTCCTGGTAAATCACCATCAGCAAATGGGCTATCCCAA
AAGCACAATGATGGAAAAGAGGAAAATGACATTCAGACTGGTAGTGCTCTGCTTCCTCTCAGCCCTGAATCTAAAGCATGGGCAGTTCTG
ACAAGTGATGAAGAAAGTGGATCAGGGCAAGGTACCTCAGATAGCCTTAATGAGAATGAGACTTCCACAGATTTCAGTTTTGCAGACACT
AATGAAAAAGATGCTGATGGGATCCTGGCAGCAGGTGACTCAGAAATAACTCCTGGATTCCCACAGTCCCCAACATCATCTGTTACTAGC
GAGAACTCAGAAGTGTTCCACGTTTCAGAGGCAGAGGCCAGTAATAGTAGCCATGAGTCTCGTATTGGTCTAGCTGAGGGGTTGGAATCC
GAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGTTCTTGTGGGTATTCTCATCTACTGGAGG
AAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCACACCTCCAACACCTATCTTTCCAATTTCA
GATCTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGATCCTCTCAATGGTGACGCTGCAGCCATG
TACCTCCACCGACCAGAAGAATACAAGCAGAAAATTAAAGAGTACATCCAGAAATACGCCACGGAGGAGGCGCTGAAAGAACAGGAAGAG
GGTACCGGGGACAGCTCATCGGAGAGCTCTATGTCTGACTTTTCCGAAGATGAGGCCCAGGATATGGAGTTGTAGTAGAAAAAGCACCTG
CTTTTCAGAAAGACTATTATTTCCTAACCATGAGAAGCAGACTATAATATTCATATTTAAACAAAGCAATTTTTTTTATTACTAAACAAG
GTTTTTATGAATAATAGCATTGATATATATATATTATATATCACCCTTTAGATCTTGATTTCTTGGTCATTTCTCAACCTGAGGTGCATA
GCATATTCCCACATTCCATTTGGTAGCAATATGCGGTCTGAATGCATGCATTCATGAGTCCATGTGGCCAAGTCAGCCTGTGTGCTACTG
AACTGTCGAAGGAAATAGCCGCTCTGATAGGTAGATGTGAGTAAAAAGAACAGGAAAAAATTGCTTCTTTTATTGGTTTCCAAAGAAACA
AACCAAACCAACCAGCTCTTGGATGTGAAGATAAAATAGTGCTTTTTTGAAATGGAGAGGAAAAACTTGGGGAGGAAGAGGCCTGCTGTG
GGGGCATCGGAGCCAGCCATGTAAGAATCAGAGCTGCTCCTTCCTGTGAATCCTAGGTGGCCCTATGTCTTCTGTGGAGTTACAGTATAA
AGCAGGGAGCTAATTAAGAGTATTAAAACTTAAAACCATTTTTTGACTCTGATTTTAAGTACATTTTTATATGTCAGTTGCTGCCCTTCA
CACTACCAGGCCCTGCAGCCACAGTGTTCTGTTGGAGAAACTTGGGGAAGTGTTTTCTGAACCAGTTCTTTTTCTTGGGGTAGAGCGTGA
AATCCAGACCTGTTTTTGAAAGGACAGCACAGGAGGAGAAAAGTGACTGGGACGATGCTTCCTCTCATCCAAAACACATGCAGAGTCACA
TCCTCATCCTAGTGTTTGGCAGTTTGAGACCGCTACCCTGAACTTAAGAGCTTTAAATATGAGGGTTGTGTTTCTGGGGGGGTTATTTTT
TTGGTGTGTGTGTGTGTGTATTGTGCTTAGAAAGGTTGCAGATTTCATCTTCACCTACCAAGAGGCGGCCGCCTCCTTGGACAAGCCGCT
CATGGACCATTAGACTTGAGAAGACGACCCACGTGGTGACTGCAAAGCCCTGGGTACTTGCCTTCATGTTCTGGTTTGGTTTTCCCTTTT
TCTGCTGCTCTTGGCAGCAGCCTGGTCATCATCTGCTTGTGGGAGTGGGAAATGGGTATTTTAGACCCAACACAGGTTCTAAATTTAAAA
CAAATAATAATTGGAACAAATAAAGGTTCTTGTACCCAGAGTGATTCTACATGGGAAAAACAAACCAGCTTTTTTCAGAGAGTGACCGAA
TAGGAAGAAGGGATTCAGAAATATGATGTAGTAGAACATGCCCTGCAGGAAGAAAATGTTTTCTCTCCTGCGTATGTTAAGAGGAAATCA
GTTTAAAATGCCTGCTAATCAAATGTCGACTCAGCTAACCATATGTCCAGGTTGCTGCAGAGTTTCTTTCAAATCTGAGTGTTGCCTGCT
GAACTCGGAGGGGAGTTTGGAGAAATTTTAGACAGCAGCTCTGTGTTCTTTTTTTGCCGCAGCCAATAAGATAATAGCAGAATTAGCCAA
TCCTAAAACCTTCTAAAGACGATTTTTGAGCATCCCACTGGGATTATTTAATTTTTCTTTTTGACGTGTGTTTTTAGTTTAGAAGTGCTG
TATTCCACAAGGTTTAAGTCAGTGAGGTTGGAAGATACCCTATCTTTTTTATTCAAAAAGCACAATCAATCTTTTGTTTGAAAATCTATA
TAAAGTACAACTTGCTTTTAGCATGATTATTTTCCTAAATAAAAAGACAAAGAATTTACTTACTTTATGTTAATTACGGGCATGAAGCAA
AAGGTTTTCTTTAAAAAAAAAAAAAAGTGCAGTGATGTAGGGCTGTGGTTAGTTAACCGTACTGAGTTATCCATCTAGCATCTGTGGCTT
GCTGGAAGGGTAGTATTAACTATTTAACATGTAATGGTGTACTTCACTCTTACCTAGCACGCTGTCTTCTCATTGCTTTGGGGGAGGGAG
GGTCTCTCTGCTGGCACTGTCTAACTTGCTTACCTGCTGACTTTGCAGTTTGCTTGTGCTATGACATTTATTGTAGGTGCTATTTAGGGT
AGGCTTAAAGTGCTGGGTGGTGATTTGAGTTCAAACAATAAAAAATTGTATTTTTTCAATATTGTATAAACAATAGTGTTCTAATTACCT
TAAAAAAAAATAATGACCAGTTAAGAATTGCTTTTGATCTTGTCAAAAAACTGAATAGACCCCAGTTTCGGGAAGGTGTGTGAGCAGTGC
CATGACTCTGCCCCTTACCTAATCCCACATCTCTCTAATGATAAGACATTGGCTCGCCTCTGACCAGAGCCCCAGCACCAGAGAGCGGAA
GATGCAGAATTGTCAAATGACCTGCTGGGGGAGGTTGTAGGAGTTTAGCAGATTTGAGTGTGGCTGCAGAGAGAGAGAGTGTGTGTATGT
GTGCACATGTGTGAGAGTGTGAGCGAGAGTGTGTGTGTGTCCATCTAAGTGTGTGTGATGAAGGTGGGATAAGGCTCCTCTGTTAGTGCT
GGAAGCTCCTGTAATTGCCGCATGGATCCCACTGTGCCCTCTTGTTCTGTGCAAGTCTGTCCTGTCTGGGCACTAACCTTGGTCCCATGC
ATGTTTATGTTCTGGGTGGGGCTTTGCCTCTCCACTGGGAAACTGACTTTTGCTGGGTTGAACAGAGTCCCTTATGCTTTTTGTCCTCTC
CCTGCGCCTGGGAGAGGTGGGAGTAGGAGCCCAAACACACAGGTACAGAAAGATCTGGAAGAAGGCCTGGCAGTGAATCCAAGGACTCTG
GGCCCCCAACAATAGATGGTAGCGTAAGTCTGGAGCAGCGGTGTTTCACCACCAAATGCCTTTCCAGGCTGCCCTTCCAACACTCAGGAG
AGCATCCAGATCCCTGGGCAGAGGCTCTACATTCTTGGCTTTAGAGGTGGTGGCAGCGGCAGCAGGTCAGAGCCACTTCTGGCGGTTTCC
CTCCCCTTTTTAGTGCCCATAGTTTTTGGATCCTCCCTTGAGTTTTACCAGCACAAGCCATTCTTTGCCCCTGTTCACATAACTGAGCTC
AAGCTCTTGCCAAACACCAACAAGCAAGATGGTTGCAACCTGGCAACATTGAATCCACCACCCTTGGGCTCCCTCTGGAAGCCCCAGCAC
CGGGGGGCTTTTGGGCACAGGGTCAGTGGTAGCCATCTTAGACACTGACATTTGGCTTTGTCGTCAATTTCATCACCCTCCTTGAGGTTA
CTGTGCAGTTTCAACCAGCATTTTATCCTAGTGAGGTCATTATCAGGAGTTGCCATATCATCTCTCCAGTACCTAACATTTCTCATCCAC
TTCAAAAGCTGTTCTGACTGCCAGCTGGCTGATCTAAGCTCCTGAGGAATGTCTCCTCTCAAAGGAATTTTTCCCTCCAAAGGCCCCCTG
AAGTCCTAGTTGGCATTGGCCTGGCACATGCTTTATGTTAGGCCTCCCGTTGGGATGGCTGAGAATCATGAAAGACAGATCCTCCGCTAG
CCTCTGTGGGTCAAGTTTCTGGACACCAAGTCTCTGGGAACTAGTGTTTGATTTTAAATGGCATGTGGCCCTTCCTTGTTTCAGTGACTT
AGAAAAGTAAAAGCCATTTAAAAAAGTTAGCAAGATTTTTTATCGACTTCCCAACTGGGCTTCCAGCCTTGTTGAATGAAATCATCTATC
TCTGATTGGGCGCAACGAACTGCATTTCTTTGGACTTCTGAATCCATGTTTGTGCTTTCTCTGGCCCGTGAACACCTCGGCGATTCTGTT
AGGGATGGGATGAGTGGGAGGAAGCCCTTTGAGAAGGGGGAGCCGGCCCTGTCATGCGCAGGTTTTCCACTCATCTGAGGAAGAGCCAGG
GCTCTGAATTTAGCCTAACACTCATCTTGGCTGTGGGCTTGGGAAGAAATGGCCATTATTTACAGATTGTATTTGGTACATATTGTGTGA
TACTTGAAAAGATAAAAGGGACTGCCAGCCCCTAACTGAAATCTGAAGCTTTTTATCGCTTATTTTTCCTCGCCCTGTCTCCTCCCTTCC
ACCTTTCTCCTTGCATTGTGATGATCTAGTAGGCACGTCTGTCAACAGGACACATGCCTCCTCTGACTATAACCTCTTAATAGTTGTGTA

>70594_70594_1_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000393386_UBE2H_chr7_129479175_ENST00000355621_length(amino acids)=1850AA_BP=1765
MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC
RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLT
NDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAII
DGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFRE
QQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNN
LLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHY
NRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTA
ESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPS
MEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDL
VSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASF
SSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMM
HARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLL
PDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKG
MFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQ
ASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSE
SSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSV
PIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMN
DSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDE
ESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA
VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHR

--------------------------------------------------------------
>70594_70594_2_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000393386_UBE2H_chr7_129479175_ENST00000473814_length(transcript)=5745nt_BP=5491nt
AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG
CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT
ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA
TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC
ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC
CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA
CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA
AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAA
ATTAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGC
AATATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTT
TCAAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTC
AAAGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAAC
TCAACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTT
AGCATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAAC
AATTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCA
GAACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATT
GAGAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCT
ATTCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAA
CTGATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAG
GGAAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACC
ACAACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGT
GATGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTG
ACTGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTG
TCGGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCT
GAAGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAAC
CCAGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTA
AAGGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTT
CTCCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCC
TCAGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGA
CAACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGGTGAGACACCTCTTCAACCTTCCTAC
AGTAGTGAAGTCTTTCCTCTAGTCACCCCTTTGTTGCTTGACAATCAGATCCTCAACACTACCCCTGCTGCTTCAAGTAGTGATTCGGCC
TTGCATGCTACGCCTGTATTTCCCAGTGTCGATGTGTCATTTGAATCCATCCTGTCTTCCTATGATGGTGCACCTTTGCTTCCATTTTCC
TCTGCTTCCTTCAGTAGTGAATTGTTTCGCCATCTGCATACAGTTTCTCAAATCCTTCCACAAGTTACTTCAGCTACCGAGAGTGATAAG
GTGCCCTTGCATGCTTCTCTGCCAGTGGCTGGGGGTGATTTGCTATTAGAGCCCAGCCTTGCTCAGTATTCTGATGTGCTGTCCACTACT
CATGCTGCTTCAGAGACGCTGGAATTTGGTAGTGAATCTGGTGTTCTTTATAAAACGCTTATGTTTTCTCAAGTTGAACCACCCAGCAGT
GATGCCATGATGCATGCACGTTCTTCAGGGCCTGAACCTTCTTATGCCTTGTCTGATAATGAGGGCTCCCAACACATCTTCACTGTTTCT
TACAGTTCTGCAATACCTGTGCATGATTCTGTGGGTGTAACTTATCAGGGTTCCTTATTTAGCGGCCCTAGCCATATACCAATACCTAAG
TCTTCGTTAATAACCCCAACTGCATCATTACTGCAGCCTACTCATGCCCTCTCTGGTGATGGGGAATGGTCTGGAGCCTCTTCTGATAGT
GAATTTCTTTTACCTGACACAGATGGGCTGACAGCCCTTAACATTTCTTCACCTGTTTCTGTAGCTGAATTTACATATACAACATCTGTG
TTTGGTGATGATAATAAGGCGCTTTCTAAAAGTGAAATAATATATGGAAATGAGACTGAACTGCAAATTCCTTCTTTCAATGAGATGGTT
TACCCTTCTGAAAGCACAGTCATGCCCAACATGTATGATAATGTAAATAAGTTGAATGCGTCTTTACAAGAAACCTCTGTTTCCATTTCT
AGCACCAAGGGCATGTTTCCAGGGTCCCTTGCTCATACCACCACTAAGGTTTTTGATCATGAGATTAGTCAAGTTCCAGAAAATAACTTT
TCAGTTCAACCTACACATACTGTCTCTCAAGCATCTGGTGACACTTCGCTTAAACCTGTGCTTAGTGCAAACTCAGAGCCAGCATCCTCT
GACCCTGCTTCTAGTGAAATGTTATCTCCTTCAACTCAGCTCTTATTTTATGAGACCTCAGCTTCTTTTAGTACTGAAGTATTGCTACAA
CCTTCCTTTCAGGCTTCTGATGTTGACACCTTGCTTAAAACTGTTCTTCCAGCTGTGCCCAGTGATCCAATATTGGTTGAAACCCCCAAA
GTTGATAAAATTAGTTCTACAATGTTGCATCTCATTGTATCAAATTCTGCTTCAAGTGAAAACATGCTGCACTCTACATCTGTACCAGTT
TTTGATGTGTCGCCTACTTCTCATATGCACTCTGCTTCACTTCAAGGTTTGACCATTTCCTATGCAAGTGAGAAATATGAACCAGTTTTG
TTAAAAAGTGAAAGTTCCCACCAAGTGGTACCTTCTTTGTACAGTAATGATGAGTTGTTCCAAACGGCCAATTTGGAGATTAACCAGGCC
CATCCCCCAAAAGGAAGGCATGTATTTGCTACACCTGTTTTATCAATTGATGAACCATTAAATACACTAATAAATAAGCTTATACATTCC
GATGAAATTTTAACCTCCACCAAAAGTTCTGTTACTGGTAAGGTATTTGCTGGTATTCCAACAGTTGCTTCTGATACATTTGTATCTACT
GATCATTCTGTTCCTATAGGAAATGGGCATGTTGCCATTACAGCTGTTTCTCCCCACAGAGATGGTTCTGTAACCTCAACAAAGTTGCTG
TTTCCTTCTAAGGCAACTTCTGAGCTGAGTCATAGTGCCAAATCTGATGCCGGTTTAGTGGGTGGTGGTGAAGATGGTGACACTGATGAT
GATGGTGATGATGATGATGATGACAGAGGTAGTGATGGCTTATCCATTCATAAGTGTATGTCATGCTCATCCTATAGAGAATCACAGGAA
AAGGTAATGAATGATTCAGACACCCACGAAAACAGTCTTATGGATCAGAATAATCCAATCTCATACTCACTATCTGAGAATTCTGAAGAA
GATAATAGAGTCACAAGTGTATCCTCAGACAGTCAAACTGGTATGGACAGAAGTCCTGGTAAATCACCATCAGCAAATGGGCTATCCCAA
AAGCACAATGATGGAAAAGAGGAAAATGACATTCAGACTGGTAGTGCTCTGCTTCCTCTCAGCCCTGAATCTAAAGCATGGGCAGTTCTG
ACAAGTGATGAAGAAAGTGGATCAGGGCAAGGTACCTCAGATAGCCTTAATGAGAATGAGACTTCCACAGATTTCAGTTTTGCAGACACT
AATGAAAAAGATGCTGATGGGATCCTGGCAGCAGGTGACTCAGAAATAACTCCTGGATTCCCACAGTCCCCAACATCATCTGTTACTAGC
GAGAACTCAGAAGTGTTCCACGTTTCAGAGGCAGAGGCCAGTAATAGTAGCCATGAGTCTCGTATTGGTCTAGCTGAGGGGTTGGAATCC
GAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGTTCTTGTGGGTATTCTCATCTACTGGAGG
AAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCACACCTCCAACACCTATCTTTCCAATTTCA
GATCTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGATCCTCTCAATGGTGACGCTGCAGCCATG
TACCTCCACCGACCAGAAGAATACAAGCAGAAAATTAAAGAGTACATCCAGAAATACGCCACGGAGGAGGCGCTGAAAGAACAGGAAGAG

>70594_70594_2_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000393386_UBE2H_chr7_129479175_ENST00000473814_length(amino acids)=1850AA_BP=1765
MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC
RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLT
NDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAII
DGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFRE
QQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNN
LLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHY
NRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTA
ESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPS
MEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDL
VSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASF
SSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMM
HARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLL
PDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKG
MFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQ
ASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSE
SSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSV
PIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMN
DSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDE
ESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA
VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHR

--------------------------------------------------------------
>70594_70594_3_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000449182_UBE2H_chr7_129479175_ENST00000355621_length(transcript)=7098nt_BP=2639nt
CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC
TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT
CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT
GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA
TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAAAT
TAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGCAA
TATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTTTC
AAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTCAA
AGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAACTC
AACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTTAG
CATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAACAA
TTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCAGA
ACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATTGA
GAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCTAT
TCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAACT
GATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAGGG
AAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACCAC
AACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGTGA
TGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTGAC
TGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTGTC
GGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCTGA
AGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAACCC
AGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTAAA
GGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTTCT
CCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCCTC
AGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGACA
ACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGAGGCCAGTAATAGTAGCCATGAGTCTCG
TATTGGTCTAGCTGAGGGGTTGGAATCCGAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGT
TCTTGTGGGTATTCTCATCTACTGGAGGAAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCAC
ACCTCCAACACCTATCTTTCCAATTTCAGATCTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGA
TCCTCTCAATGGTGACGCTGCAGCCATGTACCTCCACCGACCAGAAGAATACAAGCAGAAAATTAAAGAGTACATCCAGAAATACGCCAC
GGAGGAGGCGCTGAAAGAACAGGAAGAGGGTACCGGGGACAGCTCATCGGAGAGCTCTATGTCTGACTTTTCCGAAGATGAGGCCCAGGA
TATGGAGTTGTAGTAGAAAAAGCACCTGCTTTTCAGAAAGACTATTATTTCCTAACCATGAGAAGCAGACTATAATATTCATATTTAAAC
AAAGCAATTTTTTTTATTACTAAACAAGGTTTTTATGAATAATAGCATTGATATATATATATTATATATCACCCTTTAGATCTTGATTTC
TTGGTCATTTCTCAACCTGAGGTGCATAGCATATTCCCACATTCCATTTGGTAGCAATATGCGGTCTGAATGCATGCATTCATGAGTCCA
TGTGGCCAAGTCAGCCTGTGTGCTACTGAACTGTCGAAGGAAATAGCCGCTCTGATAGGTAGATGTGAGTAAAAAGAACAGGAAAAAATT
GCTTCTTTTATTGGTTTCCAAAGAAACAAACCAAACCAACCAGCTCTTGGATGTGAAGATAAAATAGTGCTTTTTTGAAATGGAGAGGAA
AAACTTGGGGAGGAAGAGGCCTGCTGTGGGGGCATCGGAGCCAGCCATGTAAGAATCAGAGCTGCTCCTTCCTGTGAATCCTAGGTGGCC
CTATGTCTTCTGTGGAGTTACAGTATAAAGCAGGGAGCTAATTAAGAGTATTAAAACTTAAAACCATTTTTTGACTCTGATTTTAAGTAC
ATTTTTATATGTCAGTTGCTGCCCTTCACACTACCAGGCCCTGCAGCCACAGTGTTCTGTTGGAGAAACTTGGGGAAGTGTTTTCTGAAC
CAGTTCTTTTTCTTGGGGTAGAGCGTGAAATCCAGACCTGTTTTTGAAAGGACAGCACAGGAGGAGAAAAGTGACTGGGACGATGCTTCC
TCTCATCCAAAACACATGCAGAGTCACATCCTCATCCTAGTGTTTGGCAGTTTGAGACCGCTACCCTGAACTTAAGAGCTTTAAATATGA
GGGTTGTGTTTCTGGGGGGGTTATTTTTTTGGTGTGTGTGTGTGTGTATTGTGCTTAGAAAGGTTGCAGATTTCATCTTCACCTACCAAG
AGGCGGCCGCCTCCTTGGACAAGCCGCTCATGGACCATTAGACTTGAGAAGACGACCCACGTGGTGACTGCAAAGCCCTGGGTACTTGCC
TTCATGTTCTGGTTTGGTTTTCCCTTTTTCTGCTGCTCTTGGCAGCAGCCTGGTCATCATCTGCTTGTGGGAGTGGGAAATGGGTATTTT
AGACCCAACACAGGTTCTAAATTTAAAACAAATAATAATTGGAACAAATAAAGGTTCTTGTACCCAGAGTGATTCTACATGGGAAAAACA
AACCAGCTTTTTTCAGAGAGTGACCGAATAGGAAGAAGGGATTCAGAAATATGATGTAGTAGAACATGCCCTGCAGGAAGAAAATGTTTT
CTCTCCTGCGTATGTTAAGAGGAAATCAGTTTAAAATGCCTGCTAATCAAATGTCGACTCAGCTAACCATATGTCCAGGTTGCTGCAGAG
TTTCTTTCAAATCTGAGTGTTGCCTGCTGAACTCGGAGGGGAGTTTGGAGAAATTTTAGACAGCAGCTCTGTGTTCTTTTTTTGCCGCAG
CCAATAAGATAATAGCAGAATTAGCCAATCCTAAAACCTTCTAAAGACGATTTTTGAGCATCCCACTGGGATTATTTAATTTTTCTTTTT
GACGTGTGTTTTTAGTTTAGAAGTGCTGTATTCCACAAGGTTTAAGTCAGTGAGGTTGGAAGATACCCTATCTTTTTTATTCAAAAAGCA
CAATCAATCTTTTGTTTGAAAATCTATATAAAGTACAACTTGCTTTTAGCATGATTATTTTCCTAAATAAAAAGACAAAGAATTTACTTA
CTTTATGTTAATTACGGGCATGAAGCAAAAGGTTTTCTTTAAAAAAAAAAAAAAGTGCAGTGATGTAGGGCTGTGGTTAGTTAACCGTAC
TGAGTTATCCATCTAGCATCTGTGGCTTGCTGGAAGGGTAGTATTAACTATTTAACATGTAATGGTGTACTTCACTCTTACCTAGCACGC
TGTCTTCTCATTGCTTTGGGGGAGGGAGGGTCTCTCTGCTGGCACTGTCTAACTTGCTTACCTGCTGACTTTGCAGTTTGCTTGTGCTAT
GACATTTATTGTAGGTGCTATTTAGGGTAGGCTTAAAGTGCTGGGTGGTGATTTGAGTTCAAACAATAAAAAATTGTATTTTTTCAATAT
TGTATAAACAATAGTGTTCTAATTACCTTAAAAAAAAATAATGACCAGTTAAGAATTGCTTTTGATCTTGTCAAAAAACTGAATAGACCC
CAGTTTCGGGAAGGTGTGTGAGCAGTGCCATGACTCTGCCCCTTACCTAATCCCACATCTCTCTAATGATAAGACATTGGCTCGCCTCTG
ACCAGAGCCCCAGCACCAGAGAGCGGAAGATGCAGAATTGTCAAATGACCTGCTGGGGGAGGTTGTAGGAGTTTAGCAGATTTGAGTGTG
GCTGCAGAGAGAGAGAGTGTGTGTATGTGTGCACATGTGTGAGAGTGTGAGCGAGAGTGTGTGTGTGTCCATCTAAGTGTGTGTGATGAA
GGTGGGATAAGGCTCCTCTGTTAGTGCTGGAAGCTCCTGTAATTGCCGCATGGATCCCACTGTGCCCTCTTGTTCTGTGCAAGTCTGTCC
TGTCTGGGCACTAACCTTGGTCCCATGCATGTTTATGTTCTGGGTGGGGCTTTGCCTCTCCACTGGGAAACTGACTTTTGCTGGGTTGAA
CAGAGTCCCTTATGCTTTTTGTCCTCTCCCTGCGCCTGGGAGAGGTGGGAGTAGGAGCCCAAACACACAGGTACAGAAAGATCTGGAAGA
AGGCCTGGCAGTGAATCCAAGGACTCTGGGCCCCCAACAATAGATGGTAGCGTAAGTCTGGAGCAGCGGTGTTTCACCACCAAATGCCTT
TCCAGGCTGCCCTTCCAACACTCAGGAGAGCATCCAGATCCCTGGGCAGAGGCTCTACATTCTTGGCTTTAGAGGTGGTGGCAGCGGCAG
CAGGTCAGAGCCACTTCTGGCGGTTTCCCTCCCCTTTTTAGTGCCCATAGTTTTTGGATCCTCCCTTGAGTTTTACCAGCACAAGCCATT
CTTTGCCCCTGTTCACATAACTGAGCTCAAGCTCTTGCCAAACACCAACAAGCAAGATGGTTGCAACCTGGCAACATTGAATCCACCACC
CTTGGGCTCCCTCTGGAAGCCCCAGCACCGGGGGGCTTTTGGGCACAGGGTCAGTGGTAGCCATCTTAGACACTGACATTTGGCTTTGTC
GTCAATTTCATCACCCTCCTTGAGGTTACTGTGCAGTTTCAACCAGCATTTTATCCTAGTGAGGTCATTATCAGGAGTTGCCATATCATC
TCTCCAGTACCTAACATTTCTCATCCACTTCAAAAGCTGTTCTGACTGCCAGCTGGCTGATCTAAGCTCCTGAGGAATGTCTCCTCTCAA
AGGAATTTTTCCCTCCAAAGGCCCCCTGAAGTCCTAGTTGGCATTGGCCTGGCACATGCTTTATGTTAGGCCTCCCGTTGGGATGGCTGA
GAATCATGAAAGACAGATCCTCCGCTAGCCTCTGTGGGTCAAGTTTCTGGACACCAAGTCTCTGGGAACTAGTGTTTGATTTTAAATGGC
ATGTGGCCCTTCCTTGTTTCAGTGACTTAGAAAAGTAAAAGCCATTTAAAAAAGTTAGCAAGATTTTTTATCGACTTCCCAACTGGGCTT
CCAGCCTTGTTGAATGAAATCATCTATCTCTGATTGGGCGCAACGAACTGCATTTCTTTGGACTTCTGAATCCATGTTTGTGCTTTCTCT
GGCCCGTGAACACCTCGGCGATTCTGTTAGGGATGGGATGAGTGGGAGGAAGCCCTTTGAGAAGGGGGAGCCGGCCCTGTCATGCGCAGG
TTTTCCACTCATCTGAGGAAGAGCCAGGGCTCTGAATTTAGCCTAACACTCATCTTGGCTGTGGGCTTGGGAAGAAATGGCCATTATTTA
CAGATTGTATTTGGTACATATTGTGTGATACTTGAAAAGATAAAAGGGACTGCCAGCCCCTAACTGAAATCTGAAGCTTTTTATCGCTTA
TTTTTCCTCGCCCTGTCTCCTCCCTTCCACCTTTCTCCTTGCATTGTGATGATCTAGTAGGCACGTCTGTCAACAGGACACATGCCTCCT

>70594_70594_3_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000449182_UBE2H_chr7_129479175_ENST00000355621_length(amino acids)=933AA_BP=848
MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN
VNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFS
SFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVS
ISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIE
KFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEG
KDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVT
ELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENP
ETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPS
VTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVV
LVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYAT

--------------------------------------------------------------
>70594_70594_4_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000449182_UBE2H_chr7_129479175_ENST00000473814_length(transcript)=2893nt_BP=2639nt
CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC
TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT
CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT
GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA
TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAAAT
TAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGCAA
TATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTTTC
AAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTCAA
AGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAACTC
AACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTTAG
CATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAACAA
TTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCAGA
ACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATTGA
GAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCTAT
TCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAACT
GATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAGGG
AAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACCAC
AACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGTGA
TGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTGAC
TGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTGTC
GGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCTGA
AGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAACCC
AGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTAAA
GGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTTCT
CCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCCTC
AGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGACA
ACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGAGGCCAGTAATAGTAGCCATGAGTCTCG
TATTGGTCTAGCTGAGGGGTTGGAATCCGAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGT
TCTTGTGGGTATTCTCATCTACTGGAGGAAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCAC
ACCTCCAACACCTATCTTTCCAATTTCAGATCTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGA
TCCTCTCAATGGTGACGCTGCAGCCATGTACCTCCACCGACCAGAAGAATACAAGCAGAAAATTAAAGAGTACATCCAGAAATACGCCAC
GGAGGAGGCGCTGAAAGAACAGGAAGAGGGTACCGGGGACAGCTCATCGGAGAGCTCTATGTCTGACTTTTCCGAAGATGAGGCCCAGGA

>70594_70594_4_PTPRZ1-UBE2H_PTPRZ1_chr7_121668697_ENST00000449182_UBE2H_chr7_129479175_ENST00000473814_length(amino acids)=934AA_BP=848
MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN
VNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFS
SFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVS
ISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIE
KFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEG
KDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVT
ELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENP
ETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPS
VTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVV
LVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYAT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PTPRZ1-UBE2H

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PTPRZ1-UBE2H

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PTPRZ1-UBE2H

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source