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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PUS1-SFSWAP (FusionGDB2 ID:70732)

Fusion Gene Summary for PUS1-SFSWAP

check button Fusion gene summary
Fusion gene informationFusion gene name: PUS1-SFSWAP
Fusion gene ID: 70732
HgeneTgene
Gene symbol

PUS1

SFSWAP

Gene ID

80324

6433

Gene namepseudouridine synthase 1splicing factor SWAP
SynonymsMLASA1SFRS8|SWAP
Cytomap

12q24.33

12q24.33

Type of geneprotein-codingprotein-coding
DescriptiontRNA pseudouridine synthase Amitochondrial tRNA pseudouridine synthase Apseudouridylate synthase 1tRNA pseudouridine synthase A, mitochondrialtRNA pseudouridine(38-40) synthasetRNA pseudouridylate synthase ItRNA uridine isomerase Isplicing factor, suppressor of white-apricot homologsplicing factor SWAP homologsplicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot, Drosophila ho
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000376649, ENST00000440818, 
ENST00000443358, ENST00000542167, 
ENST00000535067, 		ENST00000539506, 
ENST00000261674, ENST00000541286, 
Fusion gene scores* DoF score3 X 2 X 2=129 X 13 X 9=1053
# samples 319
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/1053*10)=-2.47043411269477
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PUS1 [Title/Abstract] AND SFSWAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPUS1(132423820)-SFSWAP(132250663), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PUS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SFSWAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A108-01APUS1chr12

132423820

-SFSWAPchr12

132250663

+
ChimerDB4BRCATCGA-E2-A108-01APUS1chr12

132423820

+SFSWAPchr12

132250663

+


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Fusion Gene ORF analysis for PUS1-SFSWAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376649ENST00000539506PUS1chr12

132423820

+SFSWAPchr12

132250663

+
5CDS-intronENST00000440818ENST00000539506PUS1chr12

132423820

+SFSWAPchr12

132250663

+
5CDS-intronENST00000443358ENST00000539506PUS1chr12

132423820

+SFSWAPchr12

132250663

+
5CDS-intronENST00000542167ENST00000539506PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000376649ENST00000261674PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000376649ENST00000541286PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000440818ENST00000261674PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000440818ENST00000541286PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000443358ENST00000261674PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000443358ENST00000541286PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000542167ENST00000261674PUS1chr12

132423820

+SFSWAPchr12

132250663

+
In-frameENST00000542167ENST00000541286PUS1chr12

132423820

+SFSWAPchr12

132250663

+
intron-3CDSENST00000535067ENST00000261674PUS1chr12

132423820

+SFSWAPchr12

132250663

+
intron-3CDSENST00000535067ENST00000541286PUS1chr12

132423820

+SFSWAPchr12

132250663

+
intron-intronENST00000535067ENST00000539506PUS1chr12

132423820

+SFSWAPchr12

132250663

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000443358PUS1chr12132423820+ENST00000261674SFSWAPchr12132250663+18056511911555454
ENST00000443358PUS1chr12132423820+ENST00000541286SFSWAPchr12132250663+18266511911711506
ENST00000376649PUS1chr12132423820+ENST00000261674SFSWAPchr12132250663+219810444371948503
ENST00000376649PUS1chr12132423820+ENST00000541286SFSWAPchr12132250663+221910444372104555
ENST00000440818PUS1chr12132423820+ENST00000261674SFSWAPchr12132250663+17766221621526454
ENST00000440818PUS1chr12132423820+ENST00000541286SFSWAPchr12132250663+17976221621682506
ENST00000542167PUS1chr12132423820+ENST00000261674SFSWAPchr12132250663+229211387532042429
ENST00000542167PUS1chr12132423820+ENST00000541286SFSWAPchr12132250663+231311387532198481

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443358ENST00000261674PUS1chr12132423820+SFSWAPchr12132250663+0.024209620.9757903
ENST00000443358ENST00000541286PUS1chr12132423820+SFSWAPchr12132250663+0.034703030.9652969
ENST00000376649ENST00000261674PUS1chr12132423820+SFSWAPchr12132250663+0.0289845340.9710154
ENST00000376649ENST00000541286PUS1chr12132423820+SFSWAPchr12132250663+0.0377850720.96221495
ENST00000440818ENST00000261674PUS1chr12132423820+SFSWAPchr12132250663+0.0252300870.97476995
ENST00000440818ENST00000541286PUS1chr12132423820+SFSWAPchr12132250663+0.037176910.9628231
ENST00000542167ENST00000261674PUS1chr12132423820+SFSWAPchr12132250663+0.0179538950.98204607
ENST00000542167ENST00000541286PUS1chr12132423820+SFSWAPchr12132250663+0.021923390.9780766

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Fusion Genomic Features for PUS1-SFSWAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PUS1chr12132423820+SFSWAPchr12132250662+3.41E-081
PUS1chr12132423820+SFSWAPchr12132250662+3.41E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PUS1-SFSWAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:132423820/chr12:132250663)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118660_663650952.0Compositional biasNote=Poly-Ala
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118754_763650952.0Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118789_951650952.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118850_853650952.0Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119660_6636501004.0Compositional biasNote=Poly-Ala
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119754_7636501004.0Compositional biasNote=Poly-Lys
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119789_9516501004.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119850_8536501004.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118165_168650952.0Compositional biasNote=Poly-Glu
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118287_290650952.0Compositional biasNote=Poly-Asp
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118382_385650952.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118413_416650952.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118420_424650952.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118434_440650952.0Compositional biasNote=Poly-Thr
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118451_454650952.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118616_619650952.0Compositional biasNote=Poly-Ser
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119165_1686501004.0Compositional biasNote=Poly-Glu
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119287_2906501004.0Compositional biasNote=Poly-Asp
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119382_3856501004.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119413_4166501004.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119420_4246501004.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119434_4406501004.0Compositional biasNote=Poly-Thr
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119451_4546501004.0Compositional biasNote=Poly-Pro
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119616_6196501004.0Compositional biasNote=Poly-Ser
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118211_253650952.0RepeatNote=SURP motif 1
TgeneSFSWAPchr12:132423820chr12:132250663ENST000002616741118459_499650952.0RepeatNote=SURP motif 2
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119211_2536501004.0RepeatNote=SURP motif 1
TgeneSFSWAPchr12:132423820chr12:132250663ENST000005412861119459_4996501004.0RepeatNote=SURP motif 2


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Fusion Gene Sequence for PUS1-SFSWAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70732_70732_1_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000376649_SFSWAP_chr12_132250663_ENST00000261674_length(transcript)=2198nt_BP=1044nt
GTGCAGTCGGTCGTTCCACTTCCGCCTTCGCCCACGTGGTCCGGCTCCGGCTCAGTCAGCCGCGTCGCGAATGGGGCAGGAGCGAGCCTC
TCTGGTCCCGACGCGGGTGGCCCGGGTCTCCTCGACTCCTGAGGAAAGCCCACCGGGCGGGGCGGGAGGTGAAGAGGCTGGGGAAGTCAG
AGGTTAACCTGGGCGTCAGGGGACGTTGGAGTTGATCCGTCAGGGTCCCGGGGCGGTCTGGGGGCAGTAGAGACGGGGCTTGGGCGCGGG
GCCTGAGAGGTCAGGGGTCAGCAGGAGTGAGGCTGGGGCGTCCAGGTCCGAGAGGTCAGGGGTCAGCTGGAGAGGGGCTGGGGCGCCGGT
TTCCCGGAGGTCAGGGGTCAGAAGGAACAGGGCTGCAGCGTCAGGGTCCGAGAGGTTAGGGGTCGGCAGAGGCGGAGCTGGGGCACTGGG
GGTCAGGGGTCGGGGATCAGGGCGGGGTCGGGTGCACTGGTAGCCTGCGCATGGGCCTCCAGCTTCGCGCGCTGTTGGGAGCCTTCGGAC
GGTGGACCCTGCGCCTGGGACCGCGTCCGTCCTGCTCGCCGCGCATGGCCGGGAACGCGGAGCCGCCGCCCGCCGGAGCCGCATGCCCCC
AGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGGGCGACCGCGTCTGGGAGGACGGAGAACATCCGGCGAAGAAGCTCAAGAGCGGTGGCG
ACGAGGAGCGGCGCGAGAAGCCGCCCAAGCGGAAGATCGTGCTGCTCATGGCCTATTCGGGCAAGGGCTACCACGGCATGCAGAGGAATG
TCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTCGTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAGGACA
TGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTGTGGCTGATTG
ACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATTCTGGCAAAGCAAAAGCTGGAAGATCGCCTCGCAGCTGCTG
CCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGTCAAAAGAGAAACAGCTTCAAGCAGAACGTAAAAGGAAAGCGGCGTTATTTTTACAGA
CCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTGGGAAAATTGAGGAGAGTCCTTTCAGTGTCGAGGAATCCAGCACTACGCCCTGCCCTC
TACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAAG
AGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCTA
GATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAG
CCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCC
GCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCA
AGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGG
AGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCA
TGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGC
TGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGTAAATTAA
TTTTTGATGACATTTTGAGTTTTAAGATTTCTGACCAGCAGTCTCTTACCTGTATATTTGTAAATATATCATGTTTCTGTGAAAATGTAT

>70732_70732_1_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000376649_SFSWAP_chr12_132250663_ENST00000261674_length(amino acids)=503AA_BP=202
MGHWGSGVGDQGGVGCTGSLRMGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKL
KSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLK
VWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESST
TPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRS
PRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESR

--------------------------------------------------------------
>70732_70732_2_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000376649_SFSWAP_chr12_132250663_ENST00000541286_length(transcript)=2219nt_BP=1044nt
GTGCAGTCGGTCGTTCCACTTCCGCCTTCGCCCACGTGGTCCGGCTCCGGCTCAGTCAGCCGCGTCGCGAATGGGGCAGGAGCGAGCCTC
TCTGGTCCCGACGCGGGTGGCCCGGGTCTCCTCGACTCCTGAGGAAAGCCCACCGGGCGGGGCGGGAGGTGAAGAGGCTGGGGAAGTCAG
AGGTTAACCTGGGCGTCAGGGGACGTTGGAGTTGATCCGTCAGGGTCCCGGGGCGGTCTGGGGGCAGTAGAGACGGGGCTTGGGCGCGGG
GCCTGAGAGGTCAGGGGTCAGCAGGAGTGAGGCTGGGGCGTCCAGGTCCGAGAGGTCAGGGGTCAGCTGGAGAGGGGCTGGGGCGCCGGT
TTCCCGGAGGTCAGGGGTCAGAAGGAACAGGGCTGCAGCGTCAGGGTCCGAGAGGTTAGGGGTCGGCAGAGGCGGAGCTGGGGCACTGGG
GGTCAGGGGTCGGGGATCAGGGCGGGGTCGGGTGCACTGGTAGCCTGCGCATGGGCCTCCAGCTTCGCGCGCTGTTGGGAGCCTTCGGAC
GGTGGACCCTGCGCCTGGGACCGCGTCCGTCCTGCTCGCCGCGCATGGCCGGGAACGCGGAGCCGCCGCCCGCCGGAGCCGCATGCCCCC
AGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGGGCGACCGCGTCTGGGAGGACGGAGAACATCCGGCGAAGAAGCTCAAGAGCGGTGGCG
ACGAGGAGCGGCGCGAGAAGCCGCCCAAGCGGAAGATCGTGCTGCTCATGGCCTATTCGGGCAAGGGCTACCACGGCATGCAGAGGAATG
TCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTCGTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAGGACA
TGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTGTGGCTGATTG
ACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATTCTGGCAAAGCAAAAGCTGGAAGATCGCCTCGCAGCTGCTG
CCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGTCAAAAGAGAAACAGCTTCAAGCAGAACGTAAAAGGAAAGCGGCGTTATTTTTACAGA
CCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTGGGAAAATTGAGGAGAGTCCTTTCAGTGTCGAGGAATCCAGCACTACGCCCTGCCCTC
TACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAAG
AGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCTA
GATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGAGTCACAGCCTCCCCAGGGACGCTGCGCG
CGGAGCCCTGTCAGAGCAGCGCGTCAGTGACAGCGGCAGCCGAGCCAGGAAGTTATCAGGCAGCCTCGACCACCACCAGATTTGACTCCG
CGAGCTCTTTTGAGGGAAAACCTGGTAAAACGTCAAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGG
AAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGA
AGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGG
CCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGG
AAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTG
CAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCA

>70732_70732_2_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000376649_SFSWAP_chr12_132250663_ENST00000541286_length(amino acids)=555AA_BP=202
MGHWGSGVGDQGGVGCTGSLRMGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKL
KSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLK
VWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESST
TPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRVTASP
GTLRAEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKTSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRS
PHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKV

--------------------------------------------------------------
>70732_70732_3_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000440818_SFSWAP_chr12_132250663_ENST00000261674_length(transcript)=1776nt_BP=622nt
CCCACGTGGTCCGGCTCCGGCTCAGTCAGCCGCGTCGCGAATGGGGCAGGAGCGAGCCTCTCTGGTCCCGACGCGGGTGGCCCGGGTCTC
CTCGACTCCTGAGGAAAGCCCACCGGGCGGGGCGGGAGGTGAAGAGGCTGGGGAAGTCAGAGCTCGCCGCGCATGGCCGGGAACGCGGAG
CCGCCGCCCGCCGGAGCCGCATGCCCCCAGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGGGCGACCGCGTCTGGGAGGACGGAGAACAT
CCGGCGAAGAAGCTCAAGAGCGGTGGCGACGAGGAGCGGCGCGAGAAGCCGCCCAAGCGGAAGATCGTGCTGCTCATGGCCTATTCGGGC
AAGGGCTACCACGGCATGCAGAGGAATGTCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTCGTCCGGTCAGGC
TGTATTCCTGAAAATCATGGTGAGGACATGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAG
GTGGTATCCCTGAAGGTGTGGCTGATTGACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATTCTGGCAAAGCAA
AAGCTGGAAGATCGCCTCGCAGCTGCTGCCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGTCAAAAGAGAAACAGCTTCAAGCAGAACGT
AAAAGGAAAGCGGCGTTATTTTTACAGACCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTGGGAAAATTGAGGAGAGTCCTTTCAGTGTC
GAGGAATCCAGCACTACGCCCTGCCCTCTACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGC
AAAAGCAAAGATCCACCGAGAGAAGAAGAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAG
TACCATTCGTCATCCAAGTCCAGGTCTAGATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGG
TCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGC
AGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAG
GCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCC
CCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCC
GTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGAC
GGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGCCTCCA
TGGACCCTTGGTGGCTTTTGTAAATTAATTTTTGATGACATTTTGAGTTTTAAGATTTCTGACCAGCAGTCTCTTACCTGTATATTTGTA

>70732_70732_3_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000440818_SFSWAP_chr12_132250663_ENST00000261674_length(amino acids)=454AA_BP=153
MAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVS
ALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEK
QLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRT
RSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSR
SRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKVRAMLAASKNLQ

--------------------------------------------------------------
>70732_70732_4_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000440818_SFSWAP_chr12_132250663_ENST00000541286_length(transcript)=1797nt_BP=622nt
CCCACGTGGTCCGGCTCCGGCTCAGTCAGCCGCGTCGCGAATGGGGCAGGAGCGAGCCTCTCTGGTCCCGACGCGGGTGGCCCGGGTCTC
CTCGACTCCTGAGGAAAGCCCACCGGGCGGGGCGGGAGGTGAAGAGGCTGGGGAAGTCAGAGCTCGCCGCGCATGGCCGGGAACGCGGAG
CCGCCGCCCGCCGGAGCCGCATGCCCCCAGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGGGCGACCGCGTCTGGGAGGACGGAGAACAT
CCGGCGAAGAAGCTCAAGAGCGGTGGCGACGAGGAGCGGCGCGAGAAGCCGCCCAAGCGGAAGATCGTGCTGCTCATGGCCTATTCGGGC
AAGGGCTACCACGGCATGCAGAGGAATGTCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTCGTCCGGTCAGGC
TGTATTCCTGAAAATCATGGTGAGGACATGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAG
GTGGTATCCCTGAAGGTGTGGCTGATTGACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATTCTGGCAAAGCAA
AAGCTGGAAGATCGCCTCGCAGCTGCTGCCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGTCAAAAGAGAAACAGCTTCAAGCAGAACGT
AAAAGGAAAGCGGCGTTATTTTTACAGACCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTGGGAAAATTGAGGAGAGTCCTTTCAGTGTC
GAGGAATCCAGCACTACGCCCTGCCCTCTACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGC
AAAAGCAAAGATCCACCGAGAGAAGAAGAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAG
TACCATTCGTCATCCAAGTCCAGGTCTAGATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGA
GTCACAGCCTCCCCAGGGACGCTGCGCGCGGAGCCCTGTCAGAGCAGCGCGTCAGTGACAGCGGCAGCCGAGCCAGGAAGTTATCAGGCA
GCCTCGACCACCACCAGATTTGACTCCGCGAGCTCTTTTGAGGGAAAACCTGGTAAAACGTCAAGGTCCCGCTCCCGGTCCCCTCGGAGG
AGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGG
ACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCC
AGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGC
CAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGAT
CTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGG

>70732_70732_4_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000440818_SFSWAP_chr12_132250663_ENST00000541286_length(amino acids)=506AA_BP=153
MAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVS
ALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEK
QLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRT
RSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRVTASPGTLRAEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKTSRSR
SRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPV

--------------------------------------------------------------
>70732_70732_5_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000443358_SFSWAP_chr12_132250663_ENST00000261674_length(transcript)=1805nt_BP=651nt
AGTTTTGTCCGCGCTCGGCCGCCGTGCAGTCGGTCGTTCCACTTCCGCCTTCGCCCACGTGGTCCGGCTCCGGCTCAGTCAGCCGCGTCG
CGAATGGGGCAGGAGCGAGCCTCTCTGGTCCCGACGCGGGTGGCCCGGGTCTCCTCGACTCCTGAGGAAAGCCCACCGGGCGGGGCGGGA
GCTCGCCGCGCATGGCCGGGAACGCGGAGCCGCCGCCCGCCGGAGCCGCATGCCCCCAGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGG
GCGACCGCGTCTGGGAGGACGGAGAACATCCGGCGAAGAAGCTCAAGAGCGGTGGCGACGAGGAGCGGCGCGAGAAGCCGCCCAAGCGGA
AGATCGTGCTGCTCATGGCCTATTCGGGCAAGGGCTACCACGGCATGCAGAGGAATGTCGGGTCCTCACAATTCAAAACAATTGAAGATG
ACTTGGTGTCCGCCCTCGTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAGGACATGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGA
CAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTGTGGCTGATTGACGACATTCTAGAAAAGATCAACAGCCACCTTC
CCTCTCACATTCGGATTCTGGCAAAGCAAAAGCTGGAAGATCGCCTCGCAGCTGCTGCCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGT
CAAAAGAGAAACAGCTTCAAGCAGAACGTAAAAGGAAAGCGGCGTTATTTTTACAGACCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTG
GGAAAATTGAGGAGAGTCCTTTCAGTGTCGAGGAATCCAGCACTACGCCCTGCCCTCTACTGACTGGAGGCAGGCCTCTGCCTACTTTAG
AAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAAGAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAA
GATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCTAGATCACACTCAAAAGCAAAGCATTCTCTTCCCA
GTGCCTATCGGACAGTGCGGCGGTCGAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGA
GTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGA
GGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGG
CCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAG
CCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCA
AAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGC
CGGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGTAAATTAATTTTTGATGACATTTTGAGTTTTAAGATTTCTG
ACCAGCAGTCTCTTACCTGTATATTTGTAAATATATCATGTTTCTGTGAAAATGTATTATGAAATAAAATGGGAGGAAACACCTTTTCTA

>70732_70732_5_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000443358_SFSWAP_chr12_132250663_ENST00000261674_length(amino acids)=454AA_BP=153
MAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVS
ALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEK
QLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRT
RSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSR
SRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKVRAMLAASKNLQ

--------------------------------------------------------------
>70732_70732_6_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000443358_SFSWAP_chr12_132250663_ENST00000541286_length(transcript)=1826nt_BP=651nt
AGTTTTGTCCGCGCTCGGCCGCCGTGCAGTCGGTCGTTCCACTTCCGCCTTCGCCCACGTGGTCCGGCTCCGGCTCAGTCAGCCGCGTCG
CGAATGGGGCAGGAGCGAGCCTCTCTGGTCCCGACGCGGGTGGCCCGGGTCTCCTCGACTCCTGAGGAAAGCCCACCGGGCGGGGCGGGA
GCTCGCCGCGCATGGCCGGGAACGCGGAGCCGCCGCCCGCCGGAGCCGCATGCCCCCAGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGG
GCGACCGCGTCTGGGAGGACGGAGAACATCCGGCGAAGAAGCTCAAGAGCGGTGGCGACGAGGAGCGGCGCGAGAAGCCGCCCAAGCGGA
AGATCGTGCTGCTCATGGCCTATTCGGGCAAGGGCTACCACGGCATGCAGAGGAATGTCGGGTCCTCACAATTCAAAACAATTGAAGATG
ACTTGGTGTCCGCCCTCGTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAGGACATGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGA
CAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTGTGGCTGATTGACGACATTCTAGAAAAGATCAACAGCCACCTTC
CCTCTCACATTCGGATTCTGGCAAAGCAAAAGCTGGAAGATCGCCTCGCAGCTGCTGCCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGT
CAAAAGAGAAACAGCTTCAAGCAGAACGTAAAAGGAAAGCGGCGTTATTTTTACAGACCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTG
GGAAAATTGAGGAGAGTCCTTTCAGTGTCGAGGAATCCAGCACTACGCCCTGCCCTCTACTGACTGGAGGCAGGCCTCTGCCTACTTTAG
AAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAAGAAGAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAA
GATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGGTCTAGATCACACTCAAAAGCAAAGCATTCTCTTCCCA
GTGCCTATCGGACAGTGCGGCGGTCGAGAGTCACAGCCTCCCCAGGGACGCTGCGCGCGGAGCCCTGTCAGAGCAGCGCGTCAGTGACAG
CGGCAGCCGAGCCAGGAAGTTATCAGGCAGCCTCGACCACCACCAGATTTGACTCCGCGAGCTCTTTTGAGGGAAAACCTGGTAAAACGT
CAAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGA
GCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGT
CCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCG
TCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTT
CTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCT
GAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGC

>70732_70732_6_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000443358_SFSWAP_chr12_132250663_ENST00000541286_length(amino acids)=506AA_BP=153
MAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVS
ALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEK
QLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRT
RSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRVTASPGTLRAEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKTSRSR
SRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPV

--------------------------------------------------------------
>70732_70732_7_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000542167_SFSWAP_chr12_132250663_ENST00000261674_length(transcript)=2292nt_BP=1138nt
AGTCAGCCGCGTCGCGAATGGGGCAGGAGCGAGCCTCTCTGGTCCCGACGCGGGTGGCCCGGGTCTCCTCGACTCCTGAGGAAAGCCCAC
CGGGCGGGGCGGGAGGTGAAGAGGCTGGGGAAGTCAGAGGTTAACCTGGGCGTCAGGGGACGTTGGAGTTGATCCGTCAGGGTCCCGGGG
CGGTCTGGGGGCAGTAGAGACGGGGCTTGGGCGCGGGGCCTGAGAGGTCAGGGGTCACCTCCTGAGTCACTGGGATTAAAAGCATACCTA
ATTATTTATTTATTTATTTATTTTTGAGACAGAGTTTTCCTCTGTCACCTAGGCTGGAGTGCAGTGGTACATTATCAGTTCACTGCAACC
TCCACTTCCCAGGTTCAAGCGATTCTCCTGCCTCAAGAGCCCGGCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGAGTTTC
ACCATGTTGGCCAGACTGGTCTCGAACTCCTGATCTCAAGTGATCCACCCTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCC
ACTGCACCTGGCCATAGATTACTTTATAGTCAATGTTTTTTTTTTAAAGTATAGGTAGCACCCACGGCACTGATTTTGTAACTGACAGAT
TGTGGAAGTAGGTGTATGCACAGGTTCAATCAAACCTGTGTTTTGATTCCATTCCACACTACCCACCCCCTAGCATGGAGCAGCCCGGCC
CCAGGGTGAGTGAGCAGAAAACAGTGTTTTCACATGAGCGTGGCAGCTCACACTTGTAATCTCAGCACTTCAGGAGGCCAGAGGAGTAAG
CGGCCAGGAGTTCGAGACCAGCCTGGGCAACATCATGGCGACCTCTGTCTGCAAAATATAAAATCTGTTTTTGTCTCCTTTTTCCAGAGG
AATGTCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTCGTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAG
GACATGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTGTGGCTG
ATTGACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATTCTGGCAAAGCAAAAGCTGGAAGATCGCCTCGCAGCT
GCTGCCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGTCAAAAGAGAAACAGCTTCAAGCAGAACGTAAAAGGAAAGCGGCGTTATTTTTA
CAGACCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTGGGAAAATTGAGGAGAGTCCTTTCAGTGTCGAGGAATCCAGCACTACGCCCTGC
CCTCTACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAA
GAAGAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGG
TCTAGATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGGTCCCGCTCCCGGTCCCCTCGGAGG
AGAGCCCACTCCCCTGAGAGACGGAGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGG
ACCCGCTCCAGAAGTCCCCACGAGAAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCC
AGCAAGCAGGCAGCGCCCCGGCCCGCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGC
CAGGAGCGCTCCAGGGGAGTCTCTCAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGAT
CTCATGGCCAAAGTCAGAGCGATGCTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGG
AGGCTGCGTGGGCTTCTGGGCAGGCTCACGCAGACGCCGGCCACACCATCCACCTGGCCGCCTCCATGGACCCTTGGTGGCTTTTGTAAA
TTAATTTTTGATGACATTTTGAGTTTTAAGATTTCTGACCAGCAGTCTCTTACCTGTATATTTGTAAATATATCATGTTTCTGTGAAAAT

>70732_70732_7_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000542167_SFSWAP_chr12_132250663_ENST00000261674_length(amino acids)=429AA_BP=128
MSVAAHTCNLSTSGGQRSKRPGVRDQPGQHHGDLCLQNIKSVFVSFFQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCA
RTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAE
AGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSL
PSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAP

--------------------------------------------------------------
>70732_70732_8_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000542167_SFSWAP_chr12_132250663_ENST00000541286_length(transcript)=2313nt_BP=1138nt
AGTCAGCCGCGTCGCGAATGGGGCAGGAGCGAGCCTCTCTGGTCCCGACGCGGGTGGCCCGGGTCTCCTCGACTCCTGAGGAAAGCCCAC
CGGGCGGGGCGGGAGGTGAAGAGGCTGGGGAAGTCAGAGGTTAACCTGGGCGTCAGGGGACGTTGGAGTTGATCCGTCAGGGTCCCGGGG
CGGTCTGGGGGCAGTAGAGACGGGGCTTGGGCGCGGGGCCTGAGAGGTCAGGGGTCACCTCCTGAGTCACTGGGATTAAAAGCATACCTA
ATTATTTATTTATTTATTTATTTTTGAGACAGAGTTTTCCTCTGTCACCTAGGCTGGAGTGCAGTGGTACATTATCAGTTCACTGCAACC
TCCACTTCCCAGGTTCAAGCGATTCTCCTGCCTCAAGAGCCCGGCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGAGTTTC
ACCATGTTGGCCAGACTGGTCTCGAACTCCTGATCTCAAGTGATCCACCCTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCC
ACTGCACCTGGCCATAGATTACTTTATAGTCAATGTTTTTTTTTTAAAGTATAGGTAGCACCCACGGCACTGATTTTGTAACTGACAGAT
TGTGGAAGTAGGTGTATGCACAGGTTCAATCAAACCTGTGTTTTGATTCCATTCCACACTACCCACCCCCTAGCATGGAGCAGCCCGGCC
CCAGGGTGAGTGAGCAGAAAACAGTGTTTTCACATGAGCGTGGCAGCTCACACTTGTAATCTCAGCACTTCAGGAGGCCAGAGGAGTAAG
CGGCCAGGAGTTCGAGACCAGCCTGGGCAACATCATGGCGACCTCTGTCTGCAAAATATAAAATCTGTTTTTGTCTCCTTTTTCCAGAGG
AATGTCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTCGTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAG
GACATGAGGAAAATGTCCTTCCAGCGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTGTGGCTG
ATTGACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATTCTGGCAAAGCAAAAGCTGGAAGATCGCCTCGCAGCT
GCTGCCCGGGAAAAGCTGGCCCAGGCGTCTAAGGAGTCAAAAGAGAAACAGCTTCAAGCAGAACGTAAAAGGAAAGCGGCGTTATTTTTA
CAGACCCTCAAAAATCCTCTGCCGGAAGCAGAAGCTGGGAAAATTGAGGAGAGTCCTTTCAGTGTCGAGGAATCCAGCACTACGCCCTGC
CCTCTACTGACTGGAGGCAGGCCTCTGCCTACTTTAGAAGTTAAACCACCCGATAGGCCTTCGAGCAAAAGCAAAGATCCACCGAGAGAA
GAAGAGAAAGAAAAGAAAAAGAAAAAGCACAAAAAAAGATCTCGAACAAGATCACGTTCTCCCAAGTACCATTCGTCATCCAAGTCCAGG
TCTAGATCACACTCAAAAGCAAAGCATTCTCTTCCCAGTGCCTATCGGACAGTGCGGCGGTCGAGAGTCACAGCCTCCCCAGGGACGCTG
CGCGCGGAGCCCTGTCAGAGCAGCGCGTCAGTGACAGCGGCAGCCGAGCCAGGAAGTTATCAGGCAGCCTCGACCACCACCAGATTTGAC
TCCGCGAGCTCTTTTGAGGGAAAACCTGGTAAAACGTCAAGGTCCCGCTCCCGGTCCCCTCGGAGGAGAGCCCACTCCCCTGAGAGACGG
AGGGAAGAGAGGAGTGTGCCCACTGCCTACCGCGTGAGCCGCAGCCCTGGGGCCAGTAGGAAGCGGACCCGCTCCAGAAGTCCCCACGAG
AAGAAGAAGAAGAGGCGGTCCCGGTCGCGGACCAAGTCCAAGGCCAGGTCTCAGTCGGTGTCACCCAGCAAGCAGGCAGCGCCCCGGCCC
GCGGCCCCCGCGGCCCACTCGGCGCACTCAGCCAGCGTCTCCCCTGTGGAGAGTCGGGGCTCCAGCCAGGAGCGCTCCAGGGGAGTCTCT
CAGGAAAAAGAAGCCCAGATCTCTTCAGCAATCGTTTCTTCCGTGCAGAGCAAAATCACTCAGGATCTCATGGCCAAAGTCAGAGCGATG
CTTGCAGCTTCCAAAAACCTGCAAACCAGCGCTTCCTGAGACGGGGCCAGCGGAGGCAGAGCCGGGAGGCTGCGTGGGCTTCTGGGCAGG

>70732_70732_8_PUS1-SFSWAP_PUS1_chr12_132423820_ENST00000542167_SFSWAP_chr12_132250663_ENST00000541286_length(amino acids)=481AA_BP=128
MSVAAHTCNLSTSGGQRSKRPGVRDQPGQHHGDLCLQNIKSVFVSFFQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCA
RTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAE
AGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSL
PSAYRTVRRSRVTASPGTLRAEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKTSRSRSRSPRRRAHSPERRREERSVPTAYR
VSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PUS1-SFSWAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PUS1-SFSWAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PUS1-SFSWAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource