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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PVR-SIRT2 (FusionGDB2 ID:70766)

Fusion Gene Summary for PVR-SIRT2

check button Fusion gene summary
Fusion gene informationFusion gene name: PVR-SIRT2
Fusion gene ID: 70766
HgeneTgene
Gene symbol

PVR

SIRT2

Gene ID

5817

22933

Gene namePVR cell adhesion moleculesirtuin 2
SynonymsCD155|HVED|NECL5|Necl-5|PVS|TAGE4SIR2|SIR2L|SIR2L2
Cytomap

19q13.31

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionpoliovirus receptornectin-like protein 5NAD-dependent protein deacetylase sirtuin-2NAD-dependent deacetylase sirtuin-2SIR2-like protein 2regulatory protein SIR2 homolog 2silent information regulator 2sir2-related protein type 2sirtuin type 2
Modification date2020032920200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000344956, ENST00000403059, 
ENST00000406449, ENST00000425690, 
ENST00000481381, ENST00000249396, 
ENST00000358931, ENST00000392081, 
Fusion gene scores* DoF score5 X 7 X 5=1756 X 6 X 6=216
# samples 67
** MAII scorelog2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PVR [Title/Abstract] AND SIRT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPVR(45147475)-SIRT2(39372131), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePVR

GO:0060370

susceptibility to T cell mediated cytotoxicity

15039383

TgeneSIRT2

GO:0000122

negative regulation of transcription by RNA polymerase II

18722353

TgeneSIRT2

GO:0006471

protein ADP-ribosylation

10381378

TgeneSIRT2

GO:0006476

protein deacetylation

17172643|20543840|21949390

TgeneSIRT2

GO:0034983

peptidyl-lysine deacetylation

23932781

TgeneSIRT2

GO:0035729

cellular response to hepatocyte growth factor stimulus

23908241

TgeneSIRT2

GO:0045843

negative regulation of striated muscle tissue development

12887892

TgeneSIRT2

GO:0045892

negative regulation of transcription, DNA-templated

12887892

TgeneSIRT2

GO:0048012

hepatocyte growth factor receptor signaling pathway

23908241

TgeneSIRT2

GO:0070933

histone H4 deacetylation

16648462|17488717

TgeneSIRT2

GO:0071219

cellular response to molecule of bacterial origin

23908241

TgeneSIRT2

GO:0071456

cellular response to hypoxia

24681946

TgeneSIRT2

GO:0090042

tubulin deacetylation

18722353|23886946


check buttonFusion gene breakpoints across PVR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SIRT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N7-A4Y8-01APVRchr19

45147475

-SIRT2chr19

39372131

-
ChimerDB4UCSTCGA-N7-A4Y8-01APVRchr19

45147475

+SIRT2chr19

39372131

-


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Fusion Gene ORF analysis for PVR-SIRT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344956ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000403059ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000406449ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
5CDS-intronENST00000425690ENST00000481381PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000344956ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000344956ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000344956ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000403059ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000403059ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000403059ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000406449ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000406449ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000406449ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000425690ENST00000249396PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000425690ENST00000358931PVRchr19

45147475

+SIRT2chr19

39372131

-
In-frameENST00000425690ENST00000392081PVRchr19

45147475

+SIRT2chr19

39372131

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425690PVRchr1945147475+ENST00000249396SIRT2chr1939372131-1515378122916264
ENST00000425690PVRchr1945147475+ENST00000392081SIRT2chr1939372131-1515378122916264
ENST00000425690PVRchr1945147475+ENST00000358931SIRT2chr1939372131-1339378122562146
ENST00000344956PVRchr1945147475+ENST00000249396SIRT2chr1939372131-1515378122916264
ENST00000344956PVRchr1945147475+ENST00000392081SIRT2chr1939372131-1515378122916264
ENST00000344956PVRchr1945147475+ENST00000358931SIRT2chr1939372131-1339378122562146
ENST00000403059PVRchr1945147475+ENST00000249396SIRT2chr1939372131-140326610804264
ENST00000403059PVRchr1945147475+ENST00000392081SIRT2chr1939372131-140326610804264
ENST00000403059PVRchr1945147475+ENST00000358931SIRT2chr1939372131-122726610450146
ENST00000406449PVRchr1945147475+ENST00000249396SIRT2chr1939372131-1216790617205
ENST00000406449PVRchr1945147475+ENST00000392081SIRT2chr1939372131-1216790617205
ENST00000406449PVRchr1945147475+ENST00000358931SIRT2chr1939372131-104079547119142

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425690ENST00000249396PVRchr1945147475+SIRT2chr1939372131-0.0410342370.9589658
ENST00000425690ENST00000392081PVRchr1945147475+SIRT2chr1939372131-0.0410342370.9589658
ENST00000425690ENST00000358931PVRchr1945147475+SIRT2chr1939372131-0.95189470.048105367
ENST00000344956ENST00000249396PVRchr1945147475+SIRT2chr1939372131-0.0410342370.9589658
ENST00000344956ENST00000392081PVRchr1945147475+SIRT2chr1939372131-0.0410342370.9589658
ENST00000344956ENST00000358931PVRchr1945147475+SIRT2chr1939372131-0.95189470.048105367
ENST00000403059ENST00000249396PVRchr1945147475+SIRT2chr1939372131-0.0501719680.9498281
ENST00000403059ENST00000392081PVRchr1945147475+SIRT2chr1939372131-0.0501719680.9498281
ENST00000403059ENST00000358931PVRchr1945147475+SIRT2chr1939372131-0.96344270.036557317
ENST00000406449ENST00000249396PVRchr1945147475+SIRT2chr1939372131-0.043729250.95627075
ENST00000406449ENST00000392081PVRchr1945147475+SIRT2chr1939372131-0.043729250.95627075
ENST00000406449ENST00000358931PVRchr1945147475+SIRT2chr1939372131-0.969006060.03099397

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Fusion Genomic Features for PVR-SIRT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PVR-SIRT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45147475/chr19:39372131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396816262_263210390.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396816286_288210390.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931814262_263210452.6666666666667Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931814286_288210452.6666666666667Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081715262_263173353.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081715286_288173353.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396816232_301210390.0RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931814232_301210452.6666666666667RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081715232_301173353.0RegionNote=Peptide inhibitor binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17145_23726365.0DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17244_32826365.0DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000344956+1724_13926365.0DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18145_23726373.0DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18244_32826373.0DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000403059+1824_13926373.0DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16145_23726393.0DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16244_32826393.0DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000406449+1624_13926393.0DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18145_23726418.0DomainNote=Ig-like C2-type 1
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18244_32826418.0DomainNote=Ig-like C2-type 2
HgenePVRchr19:45147475chr19:39372131ENST00000425690+1824_13926418.0DomainNote=Ig-like V-type
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17396_40126365.0MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18396_40126373.0MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16396_40126393.0MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18396_40126418.0MotifNote=ITIM motif
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17368_37226365.0RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18368_37226373.0RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16368_37226393.0RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18368_37226418.0RegionNote=DYNLT1 binding
HgenePVRchr19:45147475chr19:39372131ENST00000344956+1721_34326365.0Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17368_41726365.0Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000403059+1821_34326373.0Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18368_41726373.0Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000406449+1621_34326393.0Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16368_41726393.0Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000425690+1821_34326418.0Topological domainExtracellular
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18368_41726418.0Topological domainCytoplasmic
HgenePVRchr19:45147475chr19:39372131ENST00000344956+17344_36726365.0TransmembraneHelical
HgenePVRchr19:45147475chr19:39372131ENST00000403059+18344_36726373.0TransmembraneHelical
HgenePVRchr19:45147475chr19:39372131ENST00000406449+16344_36726393.0TransmembraneHelical
HgenePVRchr19:45147475chr19:39372131ENST00000425690+18344_36726418.0TransmembraneHelical
TgeneSIRT2chr19:45147475chr19:39372131ENST0000024939681665_340210390.0DomainDeacetylase sirtuin-type
TgeneSIRT2chr19:45147475chr19:39372131ENST0000035893181465_340210452.6666666666667DomainDeacetylase sirtuin-type
TgeneSIRT2chr19:45147475chr19:39372131ENST0000039208171565_340173353.0DomainDeacetylase sirtuin-type
TgeneSIRT2chr19:45147475chr19:39372131ENST0000024939681641_51210390.0MotifNote=Nuclear export signal
TgeneSIRT2chr19:45147475chr19:39372131ENST0000035893181441_51210452.6666666666667MotifNote=Nuclear export signal
TgeneSIRT2chr19:45147475chr19:39372131ENST0000039208171541_51173353.0MotifNote=Nuclear export signal
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396816167_170210390.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST0000024939681685_89210390.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST0000024939681695_97210390.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931814167_170210452.6666666666667Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST0000035893181485_89210452.6666666666667Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST0000035893181495_97210452.6666666666667Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081715167_170173353.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST0000039208171585_89173353.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST0000039208171595_97173353.0Nucleotide bindingNAD
TgeneSIRT2chr19:45147475chr19:39372131ENST00000249396816116_120210390.0RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000358931814116_120210452.6666666666667RegionNote=Peptide inhibitor binding
TgeneSIRT2chr19:45147475chr19:39372131ENST00000392081715116_120173353.0RegionNote=Peptide inhibitor binding


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Fusion Gene Sequence for PVR-SIRT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70766_70766_1_PVR-SIRT2_PVR_chr19_45147475_ENST00000344956_SIRT2_chr19_39372131_ENST00000249396_length(transcript)=1515nt_BP=378nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>70766_70766_1_PVR-SIRT2_PVR_chr19_45147475_ENST00000344956_SIRT2_chr19_39372131_ENST00000249396_length(amino acids)=264AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS
EVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGG

--------------------------------------------------------------
>70766_70766_2_PVR-SIRT2_PVR_chr19_45147475_ENST00000344956_SIRT2_chr19_39372131_ENST00000358931_length(transcript)=1339nt_BP=378nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTC
CGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCT
GCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCT
GAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCA
AAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGC
CCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAA
CTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGT
GTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAA

>70766_70766_2_PVR-SIRT2_PVR_chr19_45147475_ENST00000344956_SIRT2_chr19_39372131_ENST00000358931_length(amino acids)=146AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS

--------------------------------------------------------------
>70766_70766_3_PVR-SIRT2_PVR_chr19_45147475_ENST00000344956_SIRT2_chr19_39372131_ENST00000392081_length(transcript)=1515nt_BP=378nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>70766_70766_3_PVR-SIRT2_PVR_chr19_45147475_ENST00000344956_SIRT2_chr19_39372131_ENST00000392081_length(amino acids)=264AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS
EVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGG

--------------------------------------------------------------
>70766_70766_4_PVR-SIRT2_PVR_chr19_45147475_ENST00000403059_SIRT2_chr19_39372131_ENST00000249396_length(transcript)=1403nt_BP=266nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAA
GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCG
TTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCT
CATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGG
CCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGC
TGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAA
CCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCT
GCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGG
AGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACA
CCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCT
AACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGG
GGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTG
AGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGG

>70766_70766_4_PVR-SIRT2_PVR_chr19_45147475_ENST00000403059_SIRT2_chr19_39372131_ENST00000249396_length(amino acids)=264AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS
EVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGG

--------------------------------------------------------------
>70766_70766_5_PVR-SIRT2_PVR_chr19_45147475_ENST00000403059_SIRT2_chr19_39372131_ENST00000358931_length(transcript)=1227nt_BP=266nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAA
GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCG
TTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGGACGTGGCCTGGCTGGGTG
AATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAG
ATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAA
CAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCC
CCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCT
GGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCT
GGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTC
GGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATAT
AACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCAC

>70766_70766_5_PVR-SIRT2_PVR_chr19_45147475_ENST00000403059_SIRT2_chr19_39372131_ENST00000358931_length(amino acids)=146AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS

--------------------------------------------------------------
>70766_70766_6_PVR-SIRT2_PVR_chr19_45147475_ENST00000403059_SIRT2_chr19_39372131_ENST00000392081_length(transcript)=1403nt_BP=266nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAA
GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCG
TTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCT
CATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGG
CCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGC
TGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAA
CCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCT
GCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGG
AGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACA
CCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCT
AACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGG
GGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTG
AGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGG

>70766_70766_6_PVR-SIRT2_PVR_chr19_45147475_ENST00000403059_SIRT2_chr19_39372131_ENST00000392081_length(amino acids)=264AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS
EVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGG

--------------------------------------------------------------
>70766_70766_7_PVR-SIRT2_PVR_chr19_45147475_ENST00000406449_SIRT2_chr19_39372131_ENST00000249396_length(transcript)=1216nt_BP=79nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC
ACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTC
CCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAG
AACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTA
GAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCC
CCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTG
TGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGG
AGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGA

>70766_70766_7_PVR-SIRT2_PVR_chr19_45147475_ENST00000406449_SIRT2_chr19_39372131_ENST00000249396_length(amino acids)=205AA_BP=18
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

--------------------------------------------------------------
>70766_70766_8_PVR-SIRT2_PVR_chr19_45147475_ENST00000406449_SIRT2_chr19_39372131_ENST00000358931_length(transcript)=1040nt_BP=79nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGGACGTGGCCTGGCTGGGTGAATGCGA
CCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCA
GTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAG
GGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTA
ACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCC
AACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAA
GGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCC
CACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCAC
ACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGAC

>70766_70766_8_PVR-SIRT2_PVR_chr19_45147475_ENST00000406449_SIRT2_chr19_39372131_ENST00000358931_length(amino acids)=142AA_BP=
MLVKRGPGPVGAQLSLRSSASRLGDAAVTGVSPSLLSWPRPWQVAGTSWGKLKCWGWGPPPPTGHLCWRAPSGQGPPAPSSIQGAQQGPG

--------------------------------------------------------------
>70766_70766_9_PVR-SIRT2_PVR_chr19_45147475_ENST00000406449_SIRT2_chr19_39372131_ENST00000392081_length(transcript)=1216nt_BP=79nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTC
TCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGC
AAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGA
GGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTC
CTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGC
ACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTC
CCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAG
AACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTA
GAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCC
CCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTG
TGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGG
AGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGA

>70766_70766_9_PVR-SIRT2_PVR_chr19_45147475_ENST00000406449_SIRT2_chr19_39372131_ENST00000392081_length(amino acids)=205AA_BP=18
MARAMAAAWPLLLVALLVLSWPPPGTEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLIS
KAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPS

--------------------------------------------------------------
>70766_70766_10_PVR-SIRT2_PVR_chr19_45147475_ENST00000425690_SIRT2_chr19_39372131_ENST00000249396_length(transcript)=1515nt_BP=378nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>70766_70766_10_PVR-SIRT2_PVR_chr19_45147475_ENST00000425690_SIRT2_chr19_39372131_ENST00000249396_length(amino acids)=264AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS
EVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGG

--------------------------------------------------------------
>70766_70766_11_PVR-SIRT2_PVR_chr19_45147475_ENST00000425690_SIRT2_chr19_39372131_ENST00000358931_length(transcript)=1339nt_BP=378nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTC
CGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCT
GCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCT
GAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCA
AAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGC
CCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAA
CTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGT
GTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAA

>70766_70766_11_PVR-SIRT2_PVR_chr19_45147475_ENST00000425690_SIRT2_chr19_39372131_ENST00000358931_length(amino acids)=146AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS

--------------------------------------------------------------
>70766_70766_12_PVR-SIRT2_PVR_chr19_45147475_ENST00000425690_SIRT2_chr19_39372131_ENST00000392081_length(transcript)=1515nt_BP=378nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTT
TTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGC
AGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACC
CTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCG
ACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCC
AGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGA
GGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTT
AACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCC
CAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTA
AGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCC
CCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCA
CACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGA

>70766_70766_12_PVR-SIRT2_PVR_chr19_45147475_ENST00000425690_SIRT2_chr19_39372131_ENST00000392081_length(amino acids)=264AA_BP=77
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTEKIFS
EVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGG

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Fusion Gene PPI Analysis for PVR-SIRT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PVR-SIRT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PVR-SIRT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource