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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PVR-ZNF233 (FusionGDB2 ID:70767)

Fusion Gene Summary for PVR-ZNF233

Fusion gene summary

Fusion gene information	Fusion gene name: PVR-ZNF233
	Fusion gene ID: 70767
		Hgene	Tgene
	Gene symbol	PVR	ZNF233
	Gene ID	5817	353355
	Gene name	PVR cell adhesion molecule	zinc finger protein 233
	Synonyms	CD155\|HVED\|NECL5\|Necl-5\|PVS\|TAGE4	-
	Cytomap	19q13.31	19q13.31
	Type of gene	protein-coding	protein-coding
	Description	poliovirus receptornectin-like protein 5	zinc finger protein 233
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000344956, ENST00000403059, ENST00000406449, ENST00000425690,	ENST00000391958, ENST00000589522, ENST00000592581, ENST00000334152,
Fusion gene scores	* DoF score	5 X 7 X 5=175	5 X 3 X 4=60
	# samples	6	5
	** MAII score	log2(6/175*10)=-1.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PVR [Title/Abstract] AND ZNF233 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PVR(45150842)-ZNF233(44768467), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PVR	GO:0060370	susceptibility to T cell mediated cytotoxicity	15039383

Fusion gene breakpoints across PVR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF233 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-B5-A5OE-01A	PVR	chr19	45150842	-	ZNF233	chr19	44768467	+
ChimerDB4	UCEC	TCGA-B5-A5OE-01A	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+

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Fusion Gene ORF analysis for PVR-ZNF233

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000344956	ENST00000391958	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000344956	ENST00000589522	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000344956	ENST00000592581	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000403059	ENST00000391958	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000403059	ENST00000589522	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000403059	ENST00000592581	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000406449	ENST00000391958	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000406449	ENST00000589522	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000406449	ENST00000592581	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000425690	ENST00000391958	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000425690	ENST00000589522	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
5CDS-5UTR	ENST00000425690	ENST00000592581	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
In-frame	ENST00000344956	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
In-frame	ENST00000403059	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
In-frame	ENST00000406449	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+
In-frame	ENST00000425690	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000425690

PVR

chr19

45150842

ENST00000334152

ZNF233

chr19

44768467

2423

726

122

2422

767

ENST00000344956

PVR

chr19

45150842

ENST00000334152

ZNF233

chr19

44768467

2423

726

122

2422

767

ENST00000403059

PVR

chr19

45150842

ENST00000334152

ZNF233

chr19

44768467

2311

614

2310

767

ENST00000406449

PVR

chr19

45150842

ENST00000334152

ZNF233

chr19

44768467

2124

427

2123

707

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000425690	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+	0.004795631	0.9952043
ENST00000344956	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+	0.004795631	0.9952043
ENST00000403059	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+	0.004180147	0.9958198
ENST00000406449	ENST00000334152	PVR	chr19	45150842	+	ZNF233	chr19	44768467	+	0.003247774	0.99675226

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Fusion Genomic Features for PVR-ZNF233

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PVR	chr19	45150842	+	ZNF233	chr19	44768465	+	6.82E-05	0.9999318
PVR	chr19	45150842	+	ZNF233	chr19	44768465	+	6.82E-05	0.9999318

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PVR-ZNF233

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45150842/chr19:44768467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

24_139

142

365.0

Domain

Note=Ig-like V-type

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

24_139

142

373.0

Domain

Note=Ig-like V-type

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

24_139

142

393.0

Domain

Note=Ig-like V-type

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

24_139

142

418.0

Domain

Note=Ig-like V-type

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

8_79

671.0

Domain

KRAB

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

258_280

671.0

Zinc finger

C2H2-type 1%3B degenerate

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

311_336

671.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

342_364

671.0

Zinc finger

C2H2-type 3%3B degenerate

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

370_392

671.0

Zinc finger

C2H2-type 4%3B degenerate

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

398_420

671.0

Zinc finger

C2H2-type 5%3B degenerate

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

452_474

671.0

Zinc finger

C2H2-type 6

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

480_502

671.0

Zinc finger

C2H2-type 7

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

508_530

671.0

Zinc finger

C2H2-type 8

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

536_558

671.0

Zinc finger

C2H2-type 9

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

564_586

671.0

Zinc finger

C2H2-type 10

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

592_614

671.0

Zinc finger

C2H2-type 11

Tgene

ZNF233

chr19:45150842

chr19:44768467

ENST00000391958

620_642

671.0

Zinc finger

C2H2-type 12

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

145_237

142

365.0

Domain

Note=Ig-like C2-type 1

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

244_328

142

365.0

Domain

Note=Ig-like C2-type 2

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

145_237

142

373.0

Domain

Note=Ig-like C2-type 1

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

244_328

142

373.0

Domain

Note=Ig-like C2-type 2

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

145_237

142

393.0

Domain

Note=Ig-like C2-type 1

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

244_328

142

393.0

Domain

Note=Ig-like C2-type 2

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

145_237

142

418.0

Domain

Note=Ig-like C2-type 1

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

244_328

142

418.0

Domain

Note=Ig-like C2-type 2

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

396_401

142

365.0

Motif

Note=ITIM motif

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

396_401

142

373.0

Motif

Note=ITIM motif

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

396_401

142

393.0

Motif

Note=ITIM motif

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

396_401

142

418.0

Motif

Note=ITIM motif

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

368_372

142

365.0

Region

Note=DYNLT1 binding

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

368_372

142

373.0

Region

Note=DYNLT1 binding

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

368_372

142

393.0

Region

Note=DYNLT1 binding

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

368_372

142

418.0

Region

Note=DYNLT1 binding

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

21_343

142

365.0

Topological domain

Extracellular

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

368_417

142

365.0

Topological domain

Cytoplasmic

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

21_343

142

373.0

Topological domain

Extracellular

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

368_417

142

373.0

Topological domain

Cytoplasmic

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

21_343

142

393.0

Topological domain

Extracellular

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

368_417

142

393.0

Topological domain

Cytoplasmic

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

21_343

142

418.0

Topological domain

Extracellular

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

368_417

142

418.0

Topological domain

Cytoplasmic

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000344956

344_367

142

365.0

Transmembrane

Helical

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000403059

344_367

142

373.0

Transmembrane

Helical

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000406449

344_367

142

393.0

Transmembrane

Helical

Hgene

PVR

chr19:45150842

chr19:44768467

ENST00000425690

344_367

142

418.0

Transmembrane

Helical

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Fusion Gene Sequence for PVR-ZNF233

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>70767_70767_1_PVR-ZNF233_PVR_chr19_45150842_ENST00000344956_ZNF233_chr19_44768467_ENST00000334152_length(transcript)=2423nt_BP=726nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGGGGACGTCGTCGTGCAGGCGCCCACCCAGGTGCCCGGCTTCTTGGGCGACTCCGTGACGCTGCCCTGCTACC
TACAGGTGCCCAACATGGAGGTGACGCATGTGTCACAGCTGACTTGGGCGCGGCATGGTGAATCTGGCAGCATGGCCGTCTTCCACCAAA
CGCAGGGCCCCAGCTATTCGGAGTCCAAACGGCTGGAATTCGTGGCAGCCAGACTGGGCGCGGAGCTGCGGAATGCCTCGCTGAGGATGT
TCGGGTTGCGCGTAGAGGATGAAGGCAACTACACCTGCCTGTTCGTCACGTTCCCGCAGGGCAGCAGGAGCGTGGATATCTGGCTCCGAG
TGCTTGTTCTGCCTTCCCAGGACCCTGCCCTTCCCCAGAAGGAGCAGGAGAAAATGACCAAGTTTCAGTTATTGGCCATAAGATTGAGAT
TACATCTGCTTGATGTTGTAGGAGATGGTGACATTCAAGGATGTGGCTGTGGTCTTCACCAGGGAGGAGCTGGGGTTGCTGGACCTTGCC
CAGAGAAAGCTGTACCAAGATGTGATGCTGGAGAACTTCAGGAACCTGCTGTCAGTGGGCTATCAACCCTTCAAACTAGATGTGATATTA
CAGTTGGGAAAAGAAGACAAGCTTCGGATGATGGAGACAGAAATCCAAGGAGATGGGTGTTCAGGCAAAGAATTGCTCATCAACATGATG
ATCATGGAGTACACAAAAGAGAGAAAGCTTTTAGCCACAATAATTGTGGAAAAGACTGTGTGAAGGAATCATCCCAGCATAGCATAATCC
AATCAGGAGAGCAAACCTCTGATGAAAATGGAAAAGGCTTAAGTGTTGGCTCTAATCTTGAACTTCACCAGCAACTACACTTAAGAGACA
AGCCTCATGTAAATGTTGAGTACGGGAAGGGCATAGGTTACAGCTCAGGGCTTCCCAGGCATCAGTGTTTCCACATAGGAGAGAAATGCT
ATAGGAATGGTGACAGTGGTGAGGGCTTCAGTCAGGGCTCACATCTGCAACCTCATCAGAGAGTCAGCACAGGAGAGAACCTCTACAGAT
GTCAGGTATATGCCCGGAGCTCCAACCAGAACTCCTGTCTTCCCTCTCATGAGCTTACTCACCCAGGAGAGAAGTTGTGTACATGTGGCA
GGTGTGGGAAGGGCTTCCATCATAGCTTAGATTTTGACATTCACTGTGTAGACAGTGCTGGAGAGAGAGCCTGTAAATGTGATGTATATG
ATAAAGGCTTCAGTCAGACATCACAACTTCAAGCCCATCAGAGAGGTCACTCTAGAGACAAGACATACAAATGGGAAGTAAGTGACAGGA
TATTTAATAGGAATTCTGGTCTTCACCAGAGAGTTCACACTGGAGAGAAACCATATAAATGTGAGGTATGTGATAAGGGCTTCAGTAAGG
CCTCAAATCTTCAAGCCCATCAGAGAATCCACACTGGAGAGAAACCCTACAAATGTGATGTGTGTGATAAGAACTTCAGCCGTAATTCCC
ACCTTCAGGCCCATCAGAGAGTCCATACAGGAGAGAAACCCTACAAATGTGACACATGTGGGAAGGACTTCAGTCAGATCTCTCATCTTC
AGGCCCATCAGAGAGTTCACAAAGGAGAGAAGCCATACAAATGTGAGACATGTGGGAAGGGCTTTAGTCAGAGTTCGCATCTCCAAGACC
ATCAGCAAGTCCATACTGGAGAGAATCCCTACAAATGTGATGTGTGTGGGAAAGGCTTCAGTTGGAGTTCACATCTTCAAGCCCATCAGA
GAGTCCACACAGGAGAGAAACCATACAAATGTGAAGAATGTAGGAAAGGCTTCATCTGGAACTCATATCTTCATGTTCATCAGAGGATCC
ACACGGGAGAGAAACCCTATAAATGTGGCATGTGTGGTAAGAGCTTCAGTCAGACTTCACATCTTCAAGCCCATCAGAGAGTCCATACTG

>70767_70767_1_PVR-ZNF233_PVR_chr19_45150842_ENST00000344956_ZNF233_chr19_44768467_ENST00000334152_length(amino acids)=767AA_BP=489
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTGDVVV
QAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNY
TCLFVTFPQGSRSVDIWLRVLVLPSQDPALPQKEQEKMTKFQLLAIRLRLHLLDVVGDGDIQGCGCGLHQGGAGVAGPCPEKAVPRCDAG
ELQEPAVSGLSTLQTRCDITVGKRRQASDDGDRNPRRWVFRQRIAHQHDDHGVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENG
KGLSVGSNLELHQQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQGSHLQPHQRVSTGENLYRCQVYARSSNQN
SCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQR
VHTGEKPYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGKDFSQISHLQAHQRVHKGEK
PYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGM

--------------------------------------------------------------
>70767_70767_2_PVR-ZNF233_PVR_chr19_45150842_ENST00000403059_ZNF233_chr19_44768467_ENST00000334152_length(transcript)=2311nt_BP=614nt
AGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCCCCCGGGGATTCCAGGACCTGAG
CTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGCGGGAGGCCCAGCTGCTCGGAGC
AACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGGGGA
CGTCGTCGTGCAGGCGCCCACCCAGGTGCCCGGCTTCTTGGGCGACTCCGTGACGCTGCCCTGCTACCTACAGGTGCCCAACATGGAGGT
GACGCATGTGTCACAGCTGACTTGGGCGCGGCATGGTGAATCTGGCAGCATGGCCGTCTTCCACCAAACGCAGGGCCCCAGCTATTCGGA
GTCCAAACGGCTGGAATTCGTGGCAGCCAGACTGGGCGCGGAGCTGCGGAATGCCTCGCTGAGGATGTTCGGGTTGCGCGTAGAGGATGA
AGGCAACTACACCTGCCTGTTCGTCACGTTCCCGCAGGGCAGCAGGAGCGTGGATATCTGGCTCCGAGTGCTTGTTCTGCCTTCCCAGGA
CCCTGCCCTTCCCCAGAAGGAGCAGGAGAAAATGACCAAGTTTCAGTTATTGGCCATAAGATTGAGATTACATCTGCTTGATGTTGTAGG
AGATGGTGACATTCAAGGATGTGGCTGTGGTCTTCACCAGGGAGGAGCTGGGGTTGCTGGACCTTGCCCAGAGAAAGCTGTACCAAGATG
TGATGCTGGAGAACTTCAGGAACCTGCTGTCAGTGGGCTATCAACCCTTCAAACTAGATGTGATATTACAGTTGGGAAAAGAAGACAAGC
TTCGGATGATGGAGACAGAAATCCAAGGAGATGGGTGTTCAGGCAAAGAATTGCTCATCAACATGATGATCATGGAGTACACAAAAGAGA
GAAAGCTTTTAGCCACAATAATTGTGGAAAAGACTGTGTGAAGGAATCATCCCAGCATAGCATAATCCAATCAGGAGAGCAAACCTCTGA
TGAAAATGGAAAAGGCTTAAGTGTTGGCTCTAATCTTGAACTTCACCAGCAACTACACTTAAGAGACAAGCCTCATGTAAATGTTGAGTA
CGGGAAGGGCATAGGTTACAGCTCAGGGCTTCCCAGGCATCAGTGTTTCCACATAGGAGAGAAATGCTATAGGAATGGTGACAGTGGTGA
GGGCTTCAGTCAGGGCTCACATCTGCAACCTCATCAGAGAGTCAGCACAGGAGAGAACCTCTACAGATGTCAGGTATATGCCCGGAGCTC
CAACCAGAACTCCTGTCTTCCCTCTCATGAGCTTACTCACCCAGGAGAGAAGTTGTGTACATGTGGCAGGTGTGGGAAGGGCTTCCATCA
TAGCTTAGATTTTGACATTCACTGTGTAGACAGTGCTGGAGAGAGAGCCTGTAAATGTGATGTATATGATAAAGGCTTCAGTCAGACATC
ACAACTTCAAGCCCATCAGAGAGGTCACTCTAGAGACAAGACATACAAATGGGAAGTAAGTGACAGGATATTTAATAGGAATTCTGGTCT
TCACCAGAGAGTTCACACTGGAGAGAAACCATATAAATGTGAGGTATGTGATAAGGGCTTCAGTAAGGCCTCAAATCTTCAAGCCCATCA
GAGAATCCACACTGGAGAGAAACCCTACAAATGTGATGTGTGTGATAAGAACTTCAGCCGTAATTCCCACCTTCAGGCCCATCAGAGAGT
CCATACAGGAGAGAAACCCTACAAATGTGACACATGTGGGAAGGACTTCAGTCAGATCTCTCATCTTCAGGCCCATCAGAGAGTTCACAA
AGGAGAGAAGCCATACAAATGTGAGACATGTGGGAAGGGCTTTAGTCAGAGTTCGCATCTCCAAGACCATCAGCAAGTCCATACTGGAGA
GAATCCCTACAAATGTGATGTGTGTGGGAAAGGCTTCAGTTGGAGTTCACATCTTCAAGCCCATCAGAGAGTCCACACAGGAGAGAAACC
ATACAAATGTGAAGAATGTAGGAAAGGCTTCATCTGGAACTCATATCTTCATGTTCATCAGAGGATCCACACGGGAGAGAAACCCTATAA
ATGTGGCATGTGTGGTAAGAGCTTCAGTCAGACTTCACATCTTCAAGCCCATCAGAGAGTCCATACTGGAGAGAAACCATACAAATGTTT

>70767_70767_2_PVR-ZNF233_PVR_chr19_45150842_ENST00000403059_ZNF233_chr19_44768467_ENST00000334152_length(amino acids)=767AA_BP=489
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTGDVVV
QAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNY
TCLFVTFPQGSRSVDIWLRVLVLPSQDPALPQKEQEKMTKFQLLAIRLRLHLLDVVGDGDIQGCGCGLHQGGAGVAGPCPEKAVPRCDAG
ELQEPAVSGLSTLQTRCDITVGKRRQASDDGDRNPRRWVFRQRIAHQHDDHGVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENG
KGLSVGSNLELHQQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQGSHLQPHQRVSTGENLYRCQVYARSSNQN
SCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQR
VHTGEKPYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGKDFSQISHLQAHQRVHKGEK
PYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGM

--------------------------------------------------------------
>70767_70767_3_PVR-ZNF233_PVR_chr19_45150842_ENST00000406449_ZNF233_chr19_44768467_ENST00000334152_length(transcript)=2124nt_BP=427nt
ATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCTGGCCACCCCCAGGAACCGGGGACGTCGTC
GTGCAGGCGCCCACCCAGGTGCCCGGCTTCTTGGGCGACTCCGTGACGCTGCCCTGCTACCTACAGGTGCCCAACATGGAGGTGACGCAT
GTGTCACAGCTGACTTGGGCGCGGCATGGTGAATCTGGCAGCATGGCCGTCTTCCACCAAACGCAGGGCCCCAGCTATTCGGAGTCCAAA
CGGCTGGAATTCGTGGCAGCCAGACTGGGCGCGGAGCTGCGGAATGCCTCGCTGAGGATGTTCGGGTTGCGCGTAGAGGATGAAGGCAAC
TACACCTGCCTGTTCGTCACGTTCCCGCAGGGCAGCAGGAGCGTGGATATCTGGCTCCGAGTGCTTGTTCTGCCTTCCCAGGACCCTGCC
CTTCCCCAGAAGGAGCAGGAGAAAATGACCAAGTTTCAGTTATTGGCCATAAGATTGAGATTACATCTGCTTGATGTTGTAGGAGATGGT
GACATTCAAGGATGTGGCTGTGGTCTTCACCAGGGAGGAGCTGGGGTTGCTGGACCTTGCCCAGAGAAAGCTGTACCAAGATGTGATGCT
GGAGAACTTCAGGAACCTGCTGTCAGTGGGCTATCAACCCTTCAAACTAGATGTGATATTACAGTTGGGAAAAGAAGACAAGCTTCGGAT
GATGGAGACAGAAATCCAAGGAGATGGGTGTTCAGGCAAAGAATTGCTCATCAACATGATGATCATGGAGTACACAAAAGAGAGAAAGCT
TTTAGCCACAATAATTGTGGAAAAGACTGTGTGAAGGAATCATCCCAGCATAGCATAATCCAATCAGGAGAGCAAACCTCTGATGAAAAT
GGAAAAGGCTTAAGTGTTGGCTCTAATCTTGAACTTCACCAGCAACTACACTTAAGAGACAAGCCTCATGTAAATGTTGAGTACGGGAAG
GGCATAGGTTACAGCTCAGGGCTTCCCAGGCATCAGTGTTTCCACATAGGAGAGAAATGCTATAGGAATGGTGACAGTGGTGAGGGCTTC
AGTCAGGGCTCACATCTGCAACCTCATCAGAGAGTCAGCACAGGAGAGAACCTCTACAGATGTCAGGTATATGCCCGGAGCTCCAACCAG
AACTCCTGTCTTCCCTCTCATGAGCTTACTCACCCAGGAGAGAAGTTGTGTACATGTGGCAGGTGTGGGAAGGGCTTCCATCATAGCTTA
GATTTTGACATTCACTGTGTAGACAGTGCTGGAGAGAGAGCCTGTAAATGTGATGTATATGATAAAGGCTTCAGTCAGACATCACAACTT
CAAGCCCATCAGAGAGGTCACTCTAGAGACAAGACATACAAATGGGAAGTAAGTGACAGGATATTTAATAGGAATTCTGGTCTTCACCAG
AGAGTTCACACTGGAGAGAAACCATATAAATGTGAGGTATGTGATAAGGGCTTCAGTAAGGCCTCAAATCTTCAAGCCCATCAGAGAATC
CACACTGGAGAGAAACCCTACAAATGTGATGTGTGTGATAAGAACTTCAGCCGTAATTCCCACCTTCAGGCCCATCAGAGAGTCCATACA
GGAGAGAAACCCTACAAATGTGACACATGTGGGAAGGACTTCAGTCAGATCTCTCATCTTCAGGCCCATCAGAGAGTTCACAAAGGAGAG
AAGCCATACAAATGTGAGACATGTGGGAAGGGCTTTAGTCAGAGTTCGCATCTCCAAGACCATCAGCAAGTCCATACTGGAGAGAATCCC
TACAAATGTGATGTGTGTGGGAAAGGCTTCAGTTGGAGTTCACATCTTCAAGCCCATCAGAGAGTCCACACAGGAGAGAAACCATACAAA
TGTGAAGAATGTAGGAAAGGCTTCATCTGGAACTCATATCTTCATGTTCATCAGAGGATCCACACGGGAGAGAAACCCTATAAATGTGGC
ATGTGTGGTAAGAGCTTCAGTCAGACTTCACATCTTCAAGCCCATCAGAGAGTCCATACTGGAGAGAAACCATACAAATGTTTTGTGTGT

>70767_70767_3_PVR-ZNF233_PVR_chr19_45150842_ENST00000406449_ZNF233_chr19_44768467_ENST00000334152_length(amino acids)=707AA_BP=430
MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESK
RLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLVLPSQDPALPQKEQEKMTKFQLLAIRLRLHLLDVVGDG
DIQGCGCGLHQGGAGVAGPCPEKAVPRCDAGELQEPAVSGLSTLQTRCDITVGKRRQASDDGDRNPRRWVFRQRIAHQHDDHGVHKREKA
FSHNNCGKDCVKESSQHSIIQSGEQTSDENGKGLSVGSNLELHQQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGF
SQGSHLQPHQRVSTGENLYRCQVYARSSNQNSCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCDVYDKGFSQTSQL
QAHQRGHSRDKTYKWEVSDRIFNRNSGLHQRVHTGEKPYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHT
GEKPYKCDTCGKDFSQISHLQAHQRVHKGEKPYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRVHTGEKPYK

--------------------------------------------------------------
>70767_70767_4_PVR-ZNF233_PVR_chr19_45150842_ENST00000425690_ZNF233_chr19_44768467_ENST00000334152_length(transcript)=2423nt_BP=726nt
AGCGGGACTGAGCGCCGGGAGAGACCTGCGCAGGCGCAGGCGCGCGGGAAGGGCCAGCCTGGGTGGCCCACCCCGCGCCTGGCGGGACTG
GCCGCCAACTCCCCTCCGCTCCAGTCACTTGTCTGGAGCTTGAAGAAGTGGGTATTCCCCTTCCCACCCCAGGCACTGGAGGAGCGGCCC
CCCGGGGATTCCAGGACCTGAGCTCCGGGAGCTGGACTCGCAGCGACCGCGGCAGAGCGAGCGGGCGCCGGGAAGCGAGGAGACGCCCGC
GGGAGGCCCAGCTGCTCGGAGCAACTGGCATGGCCCGAGCCATGGCCGCCGCGTGGCCGCTGCTGCTGGTGGCGCTACTGGTGCTGTCCT
GGCCACCCCCAGGAACCGGGGACGTCGTCGTGCAGGCGCCCACCCAGGTGCCCGGCTTCTTGGGCGACTCCGTGACGCTGCCCTGCTACC
TACAGGTGCCCAACATGGAGGTGACGCATGTGTCACAGCTGACTTGGGCGCGGCATGGTGAATCTGGCAGCATGGCCGTCTTCCACCAAA
CGCAGGGCCCCAGCTATTCGGAGTCCAAACGGCTGGAATTCGTGGCAGCCAGACTGGGCGCGGAGCTGCGGAATGCCTCGCTGAGGATGT
TCGGGTTGCGCGTAGAGGATGAAGGCAACTACACCTGCCTGTTCGTCACGTTCCCGCAGGGCAGCAGGAGCGTGGATATCTGGCTCCGAG
TGCTTGTTCTGCCTTCCCAGGACCCTGCCCTTCCCCAGAAGGAGCAGGAGAAAATGACCAAGTTTCAGTTATTGGCCATAAGATTGAGAT
TACATCTGCTTGATGTTGTAGGAGATGGTGACATTCAAGGATGTGGCTGTGGTCTTCACCAGGGAGGAGCTGGGGTTGCTGGACCTTGCC
CAGAGAAAGCTGTACCAAGATGTGATGCTGGAGAACTTCAGGAACCTGCTGTCAGTGGGCTATCAACCCTTCAAACTAGATGTGATATTA
CAGTTGGGAAAAGAAGACAAGCTTCGGATGATGGAGACAGAAATCCAAGGAGATGGGTGTTCAGGCAAAGAATTGCTCATCAACATGATG
ATCATGGAGTACACAAAAGAGAGAAAGCTTTTAGCCACAATAATTGTGGAAAAGACTGTGTGAAGGAATCATCCCAGCATAGCATAATCC
AATCAGGAGAGCAAACCTCTGATGAAAATGGAAAAGGCTTAAGTGTTGGCTCTAATCTTGAACTTCACCAGCAACTACACTTAAGAGACA
AGCCTCATGTAAATGTTGAGTACGGGAAGGGCATAGGTTACAGCTCAGGGCTTCCCAGGCATCAGTGTTTCCACATAGGAGAGAAATGCT
ATAGGAATGGTGACAGTGGTGAGGGCTTCAGTCAGGGCTCACATCTGCAACCTCATCAGAGAGTCAGCACAGGAGAGAACCTCTACAGAT
GTCAGGTATATGCCCGGAGCTCCAACCAGAACTCCTGTCTTCCCTCTCATGAGCTTACTCACCCAGGAGAGAAGTTGTGTACATGTGGCA
GGTGTGGGAAGGGCTTCCATCATAGCTTAGATTTTGACATTCACTGTGTAGACAGTGCTGGAGAGAGAGCCTGTAAATGTGATGTATATG
ATAAAGGCTTCAGTCAGACATCACAACTTCAAGCCCATCAGAGAGGTCACTCTAGAGACAAGACATACAAATGGGAAGTAAGTGACAGGA
TATTTAATAGGAATTCTGGTCTTCACCAGAGAGTTCACACTGGAGAGAAACCATATAAATGTGAGGTATGTGATAAGGGCTTCAGTAAGG
CCTCAAATCTTCAAGCCCATCAGAGAATCCACACTGGAGAGAAACCCTACAAATGTGATGTGTGTGATAAGAACTTCAGCCGTAATTCCC
ACCTTCAGGCCCATCAGAGAGTCCATACAGGAGAGAAACCCTACAAATGTGACACATGTGGGAAGGACTTCAGTCAGATCTCTCATCTTC
AGGCCCATCAGAGAGTTCACAAAGGAGAGAAGCCATACAAATGTGAGACATGTGGGAAGGGCTTTAGTCAGAGTTCGCATCTCCAAGACC
ATCAGCAAGTCCATACTGGAGAGAATCCCTACAAATGTGATGTGTGTGGGAAAGGCTTCAGTTGGAGTTCACATCTTCAAGCCCATCAGA
GAGTCCACACAGGAGAGAAACCATACAAATGTGAAGAATGTAGGAAAGGCTTCATCTGGAACTCATATCTTCATGTTCATCAGAGGATCC
ACACGGGAGAGAAACCCTATAAATGTGGCATGTGTGGTAAGAGCTTCAGTCAGACTTCACATCTTCAAGCCCATCAGAGAGTCCATACTG

>70767_70767_4_PVR-ZNF233_PVR_chr19_45150842_ENST00000425690_ZNF233_chr19_44768467_ENST00000334152_length(amino acids)=767AA_BP=489
MELEEVGIPLPTPGTGGAAPRGFQDLSSGSWTRSDRGRASGRREARRRPREAQLLGATGMARAMAAAWPLLLVALLVLSWPPPGTGDVVV
QAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNY
TCLFVTFPQGSRSVDIWLRVLVLPSQDPALPQKEQEKMTKFQLLAIRLRLHLLDVVGDGDIQGCGCGLHQGGAGVAGPCPEKAVPRCDAG
ELQEPAVSGLSTLQTRCDITVGKRRQASDDGDRNPRRWVFRQRIAHQHDDHGVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENG
KGLSVGSNLELHQQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQGSHLQPHQRVSTGENLYRCQVYARSSNQN
SCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQR
VHTGEKPYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGKDFSQISHLQAHQRVHKGEK
PYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PVR-ZNF233

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PVR-ZNF233

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PVR-ZNF233

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source