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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PXMP2-DDB2 (FusionGDB2 ID:70900)

Fusion Gene Summary for PXMP2-DDB2

check button Fusion gene summary
Fusion gene informationFusion gene name: PXMP2-DDB2
Fusion gene ID: 70900
HgeneTgene
Gene symbol

PXMP2

DDB2

Gene ID

5827

1643

Gene nameperoxisomal membrane protein 2damage specific DNA binding protein 2
SynonymsMPV17L3|PMP22DDBB|UV-DDB2|XPE
Cytomap

12q24.33

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal membrane protein 222 kDa peroxisomal membrane proteinperoxisomal membrane protein 2, 22kDaDNA damage-binding protein 2DDB p48 subunitUV-DDB 2UV-damaged DNA-binding protein 2damage-specific DNA binding protein 2, 48kDaxeroderma pigmentosum group E protein
Modification date2020031320200327
UniProtAcc.

Q92466

Ensembl transtripts involved in fusion geneENST00000317479, ENST00000428960, 
ENST00000539093, ENST00000545677, 
ENST00000543589, 		ENST00000378601, 
ENST00000256996, ENST00000378600, 
ENST00000378603, 
Fusion gene scores* DoF score8 X 4 X 5=16012 X 6 X 7=504
# samples 811
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PXMP2 [Title/Abstract] AND DDB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPXMP2(133277955)-DDB2(47259387), # samples:2
Anticipated loss of major functional domain due to fusion event.PXMP2-DDB2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PXMP2-DDB2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PXMP2-DDB2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDB2

GO:0000209

protein polyubiquitination

12732143

TgeneDDB2

GO:0009411

response to UV

12732143

TgeneDDB2

GO:0035518

histone H2A monoubiquitination

22334663

TgeneDDB2

GO:0051865

protein autoubiquitination

12732143

TgeneDDB2

GO:0070914

UV-damage excision repair

22334663


check buttonFusion gene breakpoints across PXMP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3850PXMP2chr12

133277955

+DDB2chr11

47259387

+
ChimerDB4OVTCGA-29-1697PXMP2chr12

133277955

+DDB2chr11

47259387

+


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Fusion Gene ORF analysis for PXMP2-DDB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000317479ENST00000378601PXMP2chr12

133277955

+DDB2chr11

47259387

+
5CDS-3UTRENST00000428960ENST00000378601PXMP2chr12

133277955

+DDB2chr11

47259387

+
5CDS-3UTRENST00000539093ENST00000378601PXMP2chr12

133277955

+DDB2chr11

47259387

+
5CDS-3UTRENST00000545677ENST00000378601PXMP2chr12

133277955

+DDB2chr11

47259387

+
Frame-shiftENST00000539093ENST00000256996PXMP2chr12

133277955

+DDB2chr11

47259387

+
Frame-shiftENST00000539093ENST00000378600PXMP2chr12

133277955

+DDB2chr11

47259387

+
Frame-shiftENST00000539093ENST00000378603PXMP2chr12

133277955

+DDB2chr11

47259387

+
Frame-shiftENST00000545677ENST00000256996PXMP2chr12

133277955

+DDB2chr11

47259387

+
Frame-shiftENST00000545677ENST00000378600PXMP2chr12

133277955

+DDB2chr11

47259387

+
Frame-shiftENST00000545677ENST00000378603PXMP2chr12

133277955

+DDB2chr11

47259387

+
In-frameENST00000317479ENST00000256996PXMP2chr12

133277955

+DDB2chr11

47259387

+
In-frameENST00000317479ENST00000378600PXMP2chr12

133277955

+DDB2chr11

47259387

+
In-frameENST00000317479ENST00000378603PXMP2chr12

133277955

+DDB2chr11

47259387

+
In-frameENST00000428960ENST00000256996PXMP2chr12

133277955

+DDB2chr11

47259387

+
In-frameENST00000428960ENST00000378600PXMP2chr12

133277955

+DDB2chr11

47259387

+
In-frameENST00000428960ENST00000378603PXMP2chr12

133277955

+DDB2chr11

47259387

+
intron-3CDSENST00000543589ENST00000256996PXMP2chr12

133277955

+DDB2chr11

47259387

+
intron-3CDSENST00000543589ENST00000378600PXMP2chr12

133277955

+DDB2chr11

47259387

+
intron-3CDSENST00000543589ENST00000378603PXMP2chr12

133277955

+DDB2chr11

47259387

+
intron-3UTRENST00000543589ENST00000378601PXMP2chr12

133277955

+DDB2chr11

47259387

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317479PXMP2chr12133277955+ENST00000378600DDB2chr1147259387+121258420844274
ENST00000317479PXMP2chr12133277955+ENST00000378603DDB2chr1147259387+121258420844274
ENST00000317479PXMP2chr12133277955+ENST00000256996DDB2chr1147259387+121258420844274
ENST00000428960PXMP2chr12133277955+ENST00000378600DDB2chr1147259387+97434625606193
ENST00000428960PXMP2chr12133277955+ENST00000378603DDB2chr1147259387+97434625606193
ENST00000428960PXMP2chr12133277955+ENST00000256996DDB2chr1147259387+97434625606193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317479ENST00000378600PXMP2chr12133277955+DDB2chr1147259387+0.0028654580.99713457
ENST00000317479ENST00000378603PXMP2chr12133277955+DDB2chr1147259387+0.0028654580.99713457
ENST00000317479ENST00000256996PXMP2chr12133277955+DDB2chr1147259387+0.0028654580.99713457
ENST00000428960ENST00000378600PXMP2chr12133277955+DDB2chr1147259387+0.0103737120.9896263
ENST00000428960ENST00000378603PXMP2chr12133277955+DDB2chr1147259387+0.0103737120.9896263
ENST00000428960ENST00000256996PXMP2chr12133277955+DDB2chr1147259387+0.0103737120.9896263

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Fusion Genomic Features for PXMP2-DDB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PXMP2chr12133277955+DDB2chr1147259387+1.59E-081
PXMP2chr12133277955+DDB2chr1147259387+1.59E-081
PXMP2chr12133277955+DDB2chr1147259387+1.59E-081
PXMP2chr12133277955+DDB2chr1147259387+1.59E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PXMP2-DDB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133277955/chr11:47259387)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDB2

Q92466

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:9892649, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386, PubMed:14751237). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16678110, PubMed:16473935). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16678110, PubMed:16473935). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269|PubMed:10882109, ECO:0000269|PubMed:11278856, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:26572825, ECO:0000269|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269|PubMed:14751237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+45136_173173196.0Topological domainPeroxisomal
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+451_30173196.0Topological domainCytoplasmic
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+4552_75173196.0Topological domainPeroxisomal
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+4597_114173196.0Topological domainCytoplasmic
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+45115_135173196.0TransmembraneHelical
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+4531_51173196.0TransmembraneHelical
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+4576_96173196.0TransmembraneHelical
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026256_274152239.0MotifNote=DWD box
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026334_336152239.0RegionNote=Photolesion recognition
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159334_336281237.33333333333334RegionNote=Photolesion recognition
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359334_336277364.0RegionNote=Photolesion recognition
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610343_386341428.0RepeatWD 6
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610396_420341428.0RepeatWD 7
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026159_194152239.0RepeatWD 2
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026203_238152239.0RepeatWD 3
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026244_287152239.0RepeatWD 4
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026290_329152239.0RepeatWD 5
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026343_386152239.0RepeatWD 6
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026396_420152239.0RepeatWD 7
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159290_329281237.33333333333334RepeatWD 5
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159343_386281237.33333333333334RepeatWD 6
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159396_420281237.33333333333334RepeatWD 7
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359290_329277364.0RepeatWD 5
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359343_386277364.0RepeatWD 6
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359396_420277364.0RepeatWD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePXMP2chr12:133277955chr11:47259387ENST00000317479+45174_194173196.0TransmembraneHelical
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610256_274341428.0MotifNote=DWD box
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159256_274281237.33333333333334MotifNote=DWD box
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359256_274277364.0MotifNote=DWD box
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610334_336341428.0RegionNote=Photolesion recognition
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610116_151341428.0RepeatWD 1
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610159_194341428.0RepeatWD 2
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610203_238341428.0RepeatWD 3
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610244_287341428.0RepeatWD 4
TgeneDDB2chr12:133277955chr11:47259387ENST00000256996610290_329341428.0RepeatWD 5
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860026116_151152239.0RepeatWD 1
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159116_151281237.33333333333334RepeatWD 1
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159159_194281237.33333333333334RepeatWD 2
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159203_238281237.33333333333334RepeatWD 3
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860159244_287281237.33333333333334RepeatWD 4
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359116_151277364.0RepeatWD 1
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359159_194277364.0RepeatWD 2
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359203_238277364.0RepeatWD 3
TgeneDDB2chr12:133277955chr11:47259387ENST0000037860359244_287277364.0RepeatWD 4


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Fusion Gene Sequence for PXMP2-DDB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70900_70900_1_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000256996_length(transcript)=1212nt_BP=584nt
GGGCTCCGCGCCCGGCCAGCCTGAGGTGGGGTCGGTGCCCCCGGCGGCACGGCGCTGGGGAGGCGATGGCGCCGGCCGCGTCCAGGCTGC
GGGCCGAAGCCGGGCTCGGGGCGCTGCCGCGGCGGGCGCTCGCCCAGTACCTGCTCTTCCTGCGGCTCTACCCGGTGCTCACCAAGGCGG
CCACCAGTGGCATTTTGTCAGCACTTGGGAACTTCCTGGCCCAGATGATTGAGAAGAAGCGGAAAAAAGAAAACTCTAGAAGTCTGGATG
TCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCACTTCTTCTACTTCTTCATGGAACATTGGATCC
CTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGCACCGGCCTTCCTCATGTTGTTCTTCCTCATCA
TGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTTCTGGCCGGCGCTGAGGATGAACTGGCGGGTGT
GGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGGCAGCCTGGCATCCTCGCTACAACCTCATTGTTGTGGGCCGATACC
CAGATCCTAATTTCAAAAGTTGTACCCCTTATGAATTGAGGACGATCGACGTGTTCGATGGAAACTCAGGGAAGATGATGTGTCAGCTCT
ATGACCCAGAATCTTCTGGCATCAGTTCGCTTAATGAATTCAATCCCATGGGGGACACGCTGGCCTCTGCAATGGGTTACCACATTCTCA
TCTGGAGCCAGGAGGAAGCCAGGACACGGAAGTGAGAGACACTAAAGAAGGTGTGGGCCAGACAAGGCCTTGGAGCCCACACATGGGATC
AAGTCCTGCAAGCAGAGGTGGCGATTTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGGTTGGAGCAGGGGTGCTGGGACCTGGGGCACTG
TGGGACTGGGACACTTTTATGTTAATGCTCTGGACTTGCCTCCAGAGACTGCTCCAGAGTTGGTGACACAGCTGTCCCAAGGGCCCCTCT
GTATCTAGCCTGGAACCAAGGTTATCTTGGAACTAAATGACTTTTCTCCTCTCAGTGGGTGGTAGCAGAGGGATCAAGCAGTTATTTGAT

>70900_70900_1_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000256996_length(amino acids)=274AA_BP=188
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA

--------------------------------------------------------------
>70900_70900_2_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000378600_length(transcript)=1212nt_BP=584nt
GGGCTCCGCGCCCGGCCAGCCTGAGGTGGGGTCGGTGCCCCCGGCGGCACGGCGCTGGGGAGGCGATGGCGCCGGCCGCGTCCAGGCTGC
GGGCCGAAGCCGGGCTCGGGGCGCTGCCGCGGCGGGCGCTCGCCCAGTACCTGCTCTTCCTGCGGCTCTACCCGGTGCTCACCAAGGCGG
CCACCAGTGGCATTTTGTCAGCACTTGGGAACTTCCTGGCCCAGATGATTGAGAAGAAGCGGAAAAAAGAAAACTCTAGAAGTCTGGATG
TCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCACTTCTTCTACTTCTTCATGGAACATTGGATCC
CTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGCACCGGCCTTCCTCATGTTGTTCTTCCTCATCA
TGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTTCTGGCCGGCGCTGAGGATGAACTGGCGGGTGT
GGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGGCAGCCTGGCATCCTCGCTACAACCTCATTGTTGTGGGCCGATACC
CAGATCCTAATTTCAAAAGTTGTACCCCTTATGAATTGAGGACGATCGACGTGTTCGATGGAAACTCAGGGAAGATGATGTGTCAGCTCT
ATGACCCAGAATCTTCTGGCATCAGTTCGCTTAATGAATTCAATCCCATGGGGGACACGCTGGCCTCTGCAATGGGTTACCACATTCTCA
TCTGGAGCCAGGAGGAAGCCAGGACACGGAAGTGAGAGACACTAAAGAAGGTGTGGGCCAGACAAGGCCTTGGAGCCCACACATGGGATC
AAGTCCTGCAAGCAGAGGTGGCGATTTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGGTTGGAGCAGGGGTGCTGGGACCTGGGGCACTG
TGGGACTGGGACACTTTTATGTTAATGCTCTGGACTTGCCTCCAGAGACTGCTCCAGAGTTGGTGACACAGCTGTCCCAAGGGCCCCTCT
GTATCTAGCCTGGAACCAAGGTTATCTTGGAACTAAATGACTTTTCTCCTCTCAGTGGGTGGTAGCAGAGGGATCAAGCAGTTATTTGAT

>70900_70900_2_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000378600_length(amino acids)=274AA_BP=188
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA

--------------------------------------------------------------
>70900_70900_3_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000378603_length(transcript)=1212nt_BP=584nt
GGGCTCCGCGCCCGGCCAGCCTGAGGTGGGGTCGGTGCCCCCGGCGGCACGGCGCTGGGGAGGCGATGGCGCCGGCCGCGTCCAGGCTGC
GGGCCGAAGCCGGGCTCGGGGCGCTGCCGCGGCGGGCGCTCGCCCAGTACCTGCTCTTCCTGCGGCTCTACCCGGTGCTCACCAAGGCGG
CCACCAGTGGCATTTTGTCAGCACTTGGGAACTTCCTGGCCCAGATGATTGAGAAGAAGCGGAAAAAAGAAAACTCTAGAAGTCTGGATG
TCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCACTTCTTCTACTTCTTCATGGAACATTGGATCC
CTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGCACCGGCCTTCCTCATGTTGTTCTTCCTCATCA
TGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTTCTGGCCGGCGCTGAGGATGAACTGGCGGGTGT
GGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGGCAGCCTGGCATCCTCGCTACAACCTCATTGTTGTGGGCCGATACC
CAGATCCTAATTTCAAAAGTTGTACCCCTTATGAATTGAGGACGATCGACGTGTTCGATGGAAACTCAGGGAAGATGATGTGTCAGCTCT
ATGACCCAGAATCTTCTGGCATCAGTTCGCTTAATGAATTCAATCCCATGGGGGACACGCTGGCCTCTGCAATGGGTTACCACATTCTCA
TCTGGAGCCAGGAGGAAGCCAGGACACGGAAGTGAGAGACACTAAAGAAGGTGTGGGCCAGACAAGGCCTTGGAGCCCACACATGGGATC
AAGTCCTGCAAGCAGAGGTGGCGATTTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGGTTGGAGCAGGGGTGCTGGGACCTGGGGCACTG
TGGGACTGGGACACTTTTATGTTAATGCTCTGGACTTGCCTCCAGAGACTGCTCCAGAGTTGGTGACACAGCTGTCCCAAGGGCCCCTCT
GTATCTAGCCTGGAACCAAGGTTATCTTGGAACTAAATGACTTTTCTCCTCTCAGTGGGTGGTAGCAGAGGGATCAAGCAGTTATTTGAT

>70900_70900_3_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000378603_length(amino acids)=274AA_BP=188
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA

--------------------------------------------------------------
>70900_70900_4_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000256996_length(transcript)=974nt_BP=346nt
GCGGAAAAAAGAAAACTCTAGAAGTCTGGATGTCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCA
CTTCTTCTACTTCTTCATGGAACATTGGATCCCTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGC
ACCGGCCTTCCTCATGTTGTTCTTCCTCATCATGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTT
CTGGCCGGCGCTGAGGATGAACTGGCGGGTGTGGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGGCAGCCTGGCATCC
TCGCTACAACCTCATTGTTGTGGGCCGATACCCAGATCCTAATTTCAAAAGTTGTACCCCTTATGAATTGAGGACGATCGACGTGTTCGA
TGGAAACTCAGGGAAGATGATGTGTCAGCTCTATGACCCAGAATCTTCTGGCATCAGTTCGCTTAATGAATTCAATCCCATGGGGGACAC
GCTGGCCTCTGCAATGGGTTACCACATTCTCATCTGGAGCCAGGAGGAAGCCAGGACACGGAAGTGAGAGACACTAAAGAAGGTGTGGGC
CAGACAAGGCCTTGGAGCCCACACATGGGATCAAGTCCTGCAAGCAGAGGTGGCGATTTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGG
TTGGAGCAGGGGTGCTGGGACCTGGGGCACTGTGGGACTGGGACACTTTTATGTTAATGCTCTGGACTTGCCTCCAGAGACTGCTCCAGA
GTTGGTGACACAGCTGTCCCAAGGGCCCCTCTGTATCTAGCCTGGAACCAAGGTTATCTTGGAACTAAATGACTTTTCTCCTCTCAGTGG

>70900_70900_4_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000256996_length(amino acids)=193AA_BP=107
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH

--------------------------------------------------------------
>70900_70900_5_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000378600_length(transcript)=974nt_BP=346nt
GCGGAAAAAAGAAAACTCTAGAAGTCTGGATGTCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCA
CTTCTTCTACTTCTTCATGGAACATTGGATCCCTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGC
ACCGGCCTTCCTCATGTTGTTCTTCCTCATCATGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTT
CTGGCCGGCGCTGAGGATGAACTGGCGGGTGTGGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGGCAGCCTGGCATCC
TCGCTACAACCTCATTGTTGTGGGCCGATACCCAGATCCTAATTTCAAAAGTTGTACCCCTTATGAATTGAGGACGATCGACGTGTTCGA
TGGAAACTCAGGGAAGATGATGTGTCAGCTCTATGACCCAGAATCTTCTGGCATCAGTTCGCTTAATGAATTCAATCCCATGGGGGACAC
GCTGGCCTCTGCAATGGGTTACCACATTCTCATCTGGAGCCAGGAGGAAGCCAGGACACGGAAGTGAGAGACACTAAAGAAGGTGTGGGC
CAGACAAGGCCTTGGAGCCCACACATGGGATCAAGTCCTGCAAGCAGAGGTGGCGATTTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGG
TTGGAGCAGGGGTGCTGGGACCTGGGGCACTGTGGGACTGGGACACTTTTATGTTAATGCTCTGGACTTGCCTCCAGAGACTGCTCCAGA
GTTGGTGACACAGCTGTCCCAAGGGCCCCTCTGTATCTAGCCTGGAACCAAGGTTATCTTGGAACTAAATGACTTTTCTCCTCTCAGTGG

>70900_70900_5_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000378600_length(amino acids)=193AA_BP=107
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH

--------------------------------------------------------------
>70900_70900_6_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000378603_length(transcript)=974nt_BP=346nt
GCGGAAAAAAGAAAACTCTAGAAGTCTGGATGTCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCA
CTTCTTCTACTTCTTCATGGAACATTGGATCCCTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGC
ACCGGCCTTCCTCATGTTGTTCTTCCTCATCATGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTT
CTGGCCGGCGCTGAGGATGAACTGGCGGGTGTGGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGGCAGCCTGGCATCC
TCGCTACAACCTCATTGTTGTGGGCCGATACCCAGATCCTAATTTCAAAAGTTGTACCCCTTATGAATTGAGGACGATCGACGTGTTCGA
TGGAAACTCAGGGAAGATGATGTGTCAGCTCTATGACCCAGAATCTTCTGGCATCAGTTCGCTTAATGAATTCAATCCCATGGGGGACAC
GCTGGCCTCTGCAATGGGTTACCACATTCTCATCTGGAGCCAGGAGGAAGCCAGGACACGGAAGTGAGAGACACTAAAGAAGGTGTGGGC
CAGACAAGGCCTTGGAGCCCACACATGGGATCAAGTCCTGCAAGCAGAGGTGGCGATTTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGG
TTGGAGCAGGGGTGCTGGGACCTGGGGCACTGTGGGACTGGGACACTTTTATGTTAATGCTCTGGACTTGCCTCCAGAGACTGCTCCAGA
GTTGGTGACACAGCTGTCCCAAGGGCCCCTCTGTATCTAGCCTGGAACCAAGGTTATCTTGGAACTAAATGACTTTTCTCCTCTCAGTGG

>70900_70900_6_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000378603_length(amino acids)=193AA_BP=107
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PXMP2-DDB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PXMP2-DDB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PXMP2-DDB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource