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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PXMP2-SLC44A2 (FusionGDB2 ID:70905)

Fusion Gene Summary for PXMP2-SLC44A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PXMP2-SLC44A2
Fusion gene ID: 70905
HgeneTgene
Gene symbol

PXMP2

SLC44A2

Gene ID

5827

57153

Gene nameperoxisomal membrane protein 2solute carrier family 44 member 2
SynonymsMPV17L3|PMP22CTL2|PP1292
Cytomap

12q24.33

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal membrane protein 222 kDa peroxisomal membrane proteinperoxisomal membrane protein 2, 22kDacholine transporter-like protein 2solute carrier family 44 (choline transporter), member 2testicular tissue protein Li 47
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317479, ENST00000428960, 
ENST00000539093, ENST00000545677, 
ENST00000543589, 		ENST00000588214, 
ENST00000335757, ENST00000407327, 
ENST00000586078, 
Fusion gene scores* DoF score8 X 4 X 5=16010 X 11 X 8=880
# samples 820
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/880*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PXMP2 [Title/Abstract] AND SLC44A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPXMP2(133277955)-SLC44A2(10746999), # samples:1
Anticipated loss of major functional domain due to fusion event.PXMP2-SLC44A2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PXMP2-SLC44A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC44A2

GO:0015871

choline transport

20410607

TgeneSLC44A2

GO:0055085

transmembrane transport

20410607


check buttonFusion gene breakpoints across PXMP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC44A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-2524-01APXMP2chr12

133277955

+SLC44A2chr19

10746999

+


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Fusion Gene ORF analysis for PXMP2-SLC44A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317479ENST00000588214PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
5CDS-intronENST00000428960ENST00000588214PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
5CDS-intronENST00000539093ENST00000588214PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
5CDS-intronENST00000545677ENST00000588214PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
Frame-shiftENST00000539093ENST00000335757PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
Frame-shiftENST00000539093ENST00000407327PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
Frame-shiftENST00000539093ENST00000586078PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
Frame-shiftENST00000545677ENST00000335757PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
Frame-shiftENST00000545677ENST00000407327PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
Frame-shiftENST00000545677ENST00000586078PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
In-frameENST00000317479ENST00000335757PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
In-frameENST00000317479ENST00000407327PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
In-frameENST00000317479ENST00000586078PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
In-frameENST00000428960ENST00000335757PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
In-frameENST00000428960ENST00000407327PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
In-frameENST00000428960ENST00000586078PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
intron-3CDSENST00000543589ENST00000335757PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
intron-3CDSENST00000543589ENST00000407327PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
intron-3CDSENST00000543589ENST00000586078PXMP2chr12

133277955

+SLC44A2chr19

10746999

+
intron-intronENST00000543589ENST00000588214PXMP2chr12

133277955

+SLC44A2chr19

10746999

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317479PXMP2chr12133277955+ENST00000407327SLC44A2chr1910746999+2637584201471483
ENST00000317479PXMP2chr12133277955+ENST00000335757SLC44A2chr1910746999+2646584201471483
ENST00000317479PXMP2chr12133277955+ENST00000586078SLC44A2chr1910746999+3026584201486488
ENST00000428960PXMP2chr12133277955+ENST00000407327SLC44A2chr1910746999+2399346251233402
ENST00000428960PXMP2chr12133277955+ENST00000335757SLC44A2chr1910746999+2408346251233402
ENST00000428960PXMP2chr12133277955+ENST00000586078SLC44A2chr1910746999+2788346251248407

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317479ENST00000407327PXMP2chr12133277955+SLC44A2chr1910746999+0.0085476770.99145234
ENST00000317479ENST00000335757PXMP2chr12133277955+SLC44A2chr1910746999+0.0081709590.991829
ENST00000317479ENST00000586078PXMP2chr12133277955+SLC44A2chr1910746999+0.0065771230.9934229
ENST00000428960ENST00000407327PXMP2chr12133277955+SLC44A2chr1910746999+0.0123849520.9876151
ENST00000428960ENST00000335757PXMP2chr12133277955+SLC44A2chr1910746999+0.0118297650.98817027
ENST00000428960ENST00000586078PXMP2chr12133277955+SLC44A2chr1910746999+0.0103976030.9896024

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Fusion Genomic Features for PXMP2-SLC44A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PXMP2chr12133277955+SLC44A2chr1910746998+7.51E-131
PXMP2chr12133277955+SLC44A2chr1910746998+7.51E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PXMP2-SLC44A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133277955/chr19:10746999)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+45136_173173196.0Topological domainPeroxisomal
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+451_30173196.0Topological domainCytoplasmic
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+4552_75173196.0Topological domainPeroxisomal
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+4597_114173196.0Topological domainCytoplasmic
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+45115_135173196.0TransmembraneHelical
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+4531_51173196.0TransmembraneHelical
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+4576_96173196.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322481_504411707.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322526_563411707.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322585_599411707.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322621_638411707.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322660_706411707.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322481_504409705.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322526_563409705.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322585_599409705.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322621_638409705.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322660_706409705.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322481_504411712.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322526_563411712.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322585_599411712.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322621_638411712.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322660_706411712.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322458_480411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322505_525411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322564_584411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322600_620411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322639_659411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322458_480409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322505_525409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322564_584409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322600_620409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322639_659409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322458_480411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322505_525411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322564_584411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322600_620411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322639_659411712.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePXMP2chr12:133277955chr19:10746999ENST00000317479+45174_194173196.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST0000033575713221_33411707.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322254_256411707.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322278_315411707.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322337_364411707.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322386_457411707.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST00000335757132255_232411707.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST0000040732713221_33409705.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322254_256409705.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322278_315409705.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322337_364409705.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322386_457409705.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST00000407327132255_232409705.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST0000058607813221_33411712.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322254_256411712.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322278_315411712.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322337_364411712.0Topological domainCytoplasmic
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322386_457411712.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST00000586078132255_232411712.0Topological domainExtracellular
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322233_253411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322257_277411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322316_336411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST00000335757132234_54411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000003357571322365_385411707.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322233_253409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322257_277409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322316_336409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST00000407327132234_54409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000004073271322365_385409705.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322233_253411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322257_277411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322316_336411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST00000586078132234_54411712.0TransmembraneHelical
TgeneSLC44A2chr12:133277955chr19:10746999ENST000005860781322365_385411712.0TransmembraneHelical


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Fusion Gene Sequence for PXMP2-SLC44A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70905_70905_1_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000317479_SLC44A2_chr19_10746999_ENST00000335757_length(transcript)=2646nt_BP=584nt
GGGCTCCGCGCCCGGCCAGCCTGAGGTGGGGTCGGTGCCCCCGGCGGCACGGCGCTGGGGAGGCGATGGCGCCGGCCGCGTCCAGGCTGC
GGGCCGAAGCCGGGCTCGGGGCGCTGCCGCGGCGGGCGCTCGCCCAGTACCTGCTCTTCCTGCGGCTCTACCCGGTGCTCACCAAGGCGG
CCACCAGTGGCATTTTGTCAGCACTTGGGAACTTCCTGGCCCAGATGATTGAGAAGAAGCGGAAAAAAGAAAACTCTAGAAGTCTGGATG
TCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCACTTCTTCTACTTCTTCATGGAACATTGGATCC
CTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGCACCGGCCTTCCTCATGTTGTTCTTCCTCATCA
TGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTTCTGGCCGGCGCTGAGGATGAACTGGCGGGTGT
GGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGACCTTCCCCTCCTCCAATGAGTCCCGCCAATGCCCCAATGCCCGTT
GCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTGCTGGGCCTGCAGATCTTCAATGCCTTCATGTTCTTCTGGTTGG
CCAACTTCGTGCTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTACTGGGCCCTGCGCAAGCCGGACGACCTGCCGG
CCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACAGGCTCCCTGGCCTTTGGCGCGCTCATCCTGGCCATTGTGCAGA
TCATCCGTGTGATACTCGAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTTTGCCAAGTGCCTCATGACCTGTCTCAAATGCT
GCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCCTACATCATGATTGCCATCTACGGCACCAATTTCTGCACCTCGG
CCAGGAATGCCTTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAAAGTTACTGACTTCCTCTTCCTGTTGGGCAAAC
TTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACCCACCGTATCAGGATCGTGCAGGATACAGCACCACCCCTCAATT
ATTACTGGGTTCCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTTCTTCAGCGTCTATGGCATGTGTGTGGACACGC
TGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGCTCGGCCGAGAGGCCTTACTTCATGTCTTCCACCCTCAAGAAACTCTTGA
ACAAGACCAACAAGAAGGCAGCGGAGTCCTGAAGGCCCCGTGCTCCCCACCTCTCAAGGAGTCTCATGCCGCAGGGTGCTCAGTAGCTGG
GTCTGTTCCCCCAGCCCCTTGGGCTCACCTGAAGTCCTATCACTGCCGCTCTGCCCCTCCCCATGAGCCAGATCCCACCAGTTTCTGGAC
GTGGAGAGTCTGGGGCATCTCCTTCTTATGCCAAGGGGCGCTTGGAGTTTTCATGGCTGCCCCTCCAGACTGCGAGAAACAAGTAAAAAC
CCATTGGGGCCTCTTGATGTCTGGGATGGCACGTGGCCCGACCTCCACAAGCTCCCTCATGCTTCCTGTCCCCCGCTTACACGACAACGG
GCCAGACCACAGGAAGGACGGTGTTTGTGTCTGAGGGAGCTGCTGGCCACAGTGAACACCCACGTTTATTCCTGCCTGCTCCGGCCAGGA
CTGAACCCCTTCTCCACACCTGAACAGTTGGCTCAAGGGCCACCAGAAGCATTTCTTTATTATTATTATTTTTTAACCTGGACATGCATT
AAAGGGTCTATTAGCTTTCTTTCCGTCTGTCTCAACAGCTGAGATGGGGCCGCCAAGGAGTGCCTTCCTTTTGCTCCCTCCTAGCTGGGA
GTGACGGGTGGGAGTGTGTGTGCCCAGGTGGGGGTGTCTCCTGGCTGGGAAGGAGGGAAAGGGAGGGAGAGTTTTGCGGGGGTTGGCAGT
GGAGAGCAGGCTGGAGAGGAGATGGCTAATAGCTGTTTAATGGAAACCTGCTGGGCTGGAGGGAGTTAGGCTGAATTTCCCGACTTCCTC
TGCCAGTTATTGACACAGCTCTCTTTGTAAGAGAGGAAAGAAACTAAACCCACCCAAGGGATGATGTCAGGGGGAGAGGTGGAGGGCAGA
TGTCCTGGGCAAACCGGGCCCCTCTGCCCACACACCTCACTTGATCCTTTTGCCAAACTTGTCAAACTCAGGGGAACTGGCTTCCCAGTT
GCCCCTTTGCCATATTCCAAGTCCCCCTCAGACTTCATGTCTCTGCTCATCAGCACTGTCCCAGGATCCTGGAGAGGGAGAACTCCTGGC
CCCAGGGGAAAGAGGGGGGGGTCTCCCGTTTCCTGTGCCTGCACCAGCCCTGCCCCCATTGCGTCTGCACACCCCTGCGTGTAACTGCAT

>70905_70905_1_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000317479_SLC44A2_chr19_10746999_ENST00000335757_length(amino acids)=483AA_BP=389
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKTFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSA
FGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFL
LMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLE

--------------------------------------------------------------
>70905_70905_2_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000317479_SLC44A2_chr19_10746999_ENST00000407327_length(transcript)=2637nt_BP=584nt
GGGCTCCGCGCCCGGCCAGCCTGAGGTGGGGTCGGTGCCCCCGGCGGCACGGCGCTGGGGAGGCGATGGCGCCGGCCGCGTCCAGGCTGC
GGGCCGAAGCCGGGCTCGGGGCGCTGCCGCGGCGGGCGCTCGCCCAGTACCTGCTCTTCCTGCGGCTCTACCCGGTGCTCACCAAGGCGG
CCACCAGTGGCATTTTGTCAGCACTTGGGAACTTCCTGGCCCAGATGATTGAGAAGAAGCGGAAAAAAGAAAACTCTAGAAGTCTGGATG
TCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCACTTCTTCTACTTCTTCATGGAACATTGGATCC
CTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGCACCGGCCTTCCTCATGTTGTTCTTCCTCATCA
TGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTTCTGGCCGGCGCTGAGGATGAACTGGCGGGTGT
GGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGACCTTCCCCTCCTCCAATGAGTCCCGCCAATGCCCCAATGCCCGTT
GCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTGCTGGGCCTGCAGATCTTCAATGCCTTCATGTTCTTCTGGTTGG
CCAACTTCGTGCTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTACTGGGCCCTGCGCAAGCCGGACGACCTGCCGG
CCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACAGGCTCCCTGGCCTTTGGCGCGCTCATCCTGGCCATTGTGCAGA
TCATCCGTGTGATACTCGAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTTTGCCAAGTGCCTCATGACCTGTCTCAAATGCT
GCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCCTACATCATGATTGCCATCTACGGCACCAATTTCTGCACCTCGG
CCAGGAATGCCTTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAAAGTTACTGACTTCCTCTTCCTGTTGGGCAAAC
TTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACCCACCGTATCAGGATCGTGCAGGATACAGCACCACCCCTCAATT
ATTACTGGGTTCCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTTCTTCAGCGTCTATGGCATGTGTGTGGACACGC
TGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGCTCGGCCGAGAGGCCTTACTTCATGTCTTCCACCCTCAAGAAACTCTTGA
ACAAGACCAACAAGAAGGCAGCGGAGTCCTGAAGGCCCCGTGCTCCCCACCTCTCAAGGAGTCTCATGCCGCAGGGTGCTCAGTAGCTGG
GTCTGTTCCCCCAGCCCCTTGGGCTCACCTGAAGTCCTATCACTGCCGCTCTGCCCCTCCCCATGAGCCAGATCCCACCAGTTTCTGGAC
GTGGAGAGTCTGGGGCATCTCCTTCTTATGCCAAGGGGCGCTTGGAGTTTTCATGGCTGCCCCTCCAGACTGCGAGAAACAAGTAAAAAC
CCATTGGGGCCTCTTGATGTCTGGGATGGCACGTGGCCCGACCTCCACAAGCTCCCTCATGCTTCCTGTCCCCCGCTTACACGACAACGG
GCCAGACCACAGGAAGGACGGTGTTTGTGTCTGAGGGAGCTGCTGGCCACAGTGAACACCCACGTTTATTCCTGCCTGCTCCGGCCAGGA
CTGAACCCCTTCTCCACACCTGAACAGTTGGCTCAAGGGCCACCAGAAGCATTTCTTTATTATTATTATTTTTTAACCTGGACATGCATT
AAAGGGTCTATTAGCTTTCTTTCCGTCTGTCTCAACAGCTGAGATGGGGCCGCCAAGGAGTGCCTTCCTTTTGCTCCCTCCTAGCTGGGA
GTGACGGGTGGGAGTGTGTGTGCCCAGGTGGGGGTGTCTCCTGGCTGGGAAGGAGGGAAAGGGAGGGAGAGTTTTGCGGGGGTTGGCAGT
GGAGAGCAGGCTGGAGAGGAGATGGCTAATAGCTGTTTAATGGAAACCTGCTGGGCTGGAGGGAGTTAGGCTGAATTTCCCGACTTCCTC
TGCCAGTTATTGACACAGCTCTCTTTGTAAGAGAGGAAAGAAACTAAACCCACCCAAGGGATGATGTCAGGGGGAGAGGTGGAGGGCAGA
TGTCCTGGGCAAACCGGGCCCCTCTGCCCACACACCTCACTTGATCCTTTTGCCAAACTTGTCAAACTCAGGGGAACTGGCTTCCCAGTT
GCCCCTTTGCCATATTCCAAGTCCCCCTCAGACTTCATGTCTCTGCTCATCAGCACTGTCCCAGGATCCTGGAGAGGGAGAACTCCTGGC
CCCAGGGGAAAGAGGGGGGGGTCTCCCGTTTCCTGTGCCTGCACCAGCCCTGCCCCCATTGCGTCTGCACACCCCTGCGTGTAACTGCAT

>70905_70905_2_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000317479_SLC44A2_chr19_10746999_ENST00000407327_length(amino acids)=483AA_BP=389
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKTFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSA
FGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFL
LMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLE

--------------------------------------------------------------
>70905_70905_3_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000317479_SLC44A2_chr19_10746999_ENST00000586078_length(transcript)=3026nt_BP=584nt
GGGCTCCGCGCCCGGCCAGCCTGAGGTGGGGTCGGTGCCCCCGGCGGCACGGCGCTGGGGAGGCGATGGCGCCGGCCGCGTCCAGGCTGC
GGGCCGAAGCCGGGCTCGGGGCGCTGCCGCGGCGGGCGCTCGCCCAGTACCTGCTCTTCCTGCGGCTCTACCCGGTGCTCACCAAGGCGG
CCACCAGTGGCATTTTGTCAGCACTTGGGAACTTCCTGGCCCAGATGATTGAGAAGAAGCGGAAAAAAGAAAACTCTAGAAGTCTGGATG
TCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCACTTCTTCTACTTCTTCATGGAACATTGGATCC
CTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGCACCGGCCTTCCTCATGTTGTTCTTCCTCATCA
TGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTTCTGGCCGGCGCTGAGGATGAACTGGCGGGTGT
GGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGACCTTCCCCTCCTCCAATGAGTCCCGCCAATGCCCCAATGCCCGTT
GCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTGCTGGGCCTGCAGATCTTCAATGCCTTCATGTTCTTCTGGTTGG
CCAACTTCGTGCTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTACTGGGCCCTGCGCAAGCCGGACGACCTGCCGG
CCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACAGGCTCCCTGGCCTTTGGCGCGCTCATCCTGGCCATTGTGCAGA
TCATCCGTGTGATACTCGAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTTTGCCAAGTGCCTCATGACCTGTCTCAAATGCT
GCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCCTACATCATGATTGCCATCTACGGCACCAATTTCTGCACCTCGG
CCAGGAATGCCTTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAAAGTTACTGACTTCCTCTTCCTGTTGGGCAAAC
TTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACCCACCGTATCAGGATCGTGCAGGATACAGCACCACCCCTCAATT
ATTACTGGGTTCCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTTCTTCAGCGTCTATGGCATGTGTGTGGACACGC
TGTTCCTCTGCTTCTGTGAGGACCTGGAAAGGAATGACGGCTCTCAGGAGCGACCCTACTTCATGTCGCCCGAGCTGAGAGACATCCTGT
TGAAGGGGAGTGCGGAGGAGGGGAAGCGGGCAGAAGCCGAGGAGTAGAGAGTGAGGGAGACTGGCGTGGGGGCCAGGTTTCCTCCATGTA
GACTGGGGGTGCATGAAGCGGGGGGGTTCCTGGCCTGCGAGTGTGGGGATCCTGTGTGTCCCTCGGAGCCCACTACAGTCTGCCCCTCTC
TGGTCCCAGTGTGTCTGCTTTCTAACCCTCTGAGGCTTCTCTGTGACCCTCATCCACCTACCCTGTCCTTGAGGCCCCTGCCCGTGGGCT
CCCCTCATGCCTCCTGCTCTGGGACCTCTCTCCACAGTGGAGGACCTGGAGAGGAATGACGGCTCGGCCGAGAGGCCTTACTTCATGTCT
TCCACCCTCAAGAAACTCTTGAACAAGACCAACAAGAAGGCAGCGGAGTCCTGAAGGCCCCGTGCTCCCCACCTCTCAAGGAGTCTCATG
CCGCAGGGTGCTCAGTAGCTGGGTCTGTTCCCCCAGCCCCTTGGGCTCACCTGAAGTCCTATCACTGCCGCTCTGCCCCTCCCCATGAGC
CAGATCCCACCAGTTTCTGGACGTGGAGAGTCTGGGGCATCTCCTTCTTATGCCAAGGGGCGCTTGGAGTTTTCATGGCTGCCCCTCCAG
ACTGCGAGAAACAAGTAAAAACCCATTGGGGCCTCTTGATGTCTGGGATGGCACGTGGCCCGACCTCCACAAGCTCCCTCATGCTTCCTG
TCCCCCGCTTACACGACAACGGGCCAGACCACAGGAAGGACGGTGTTTGTGTCTGAGGGAGCTGCTGGCCACAGTGAACACCCACGTTTA
TTCCTGCCTGCTCCGGCCAGGACTGAACCCCTTCTCCACACCTGAACAGTTGGCTCAAGGGCCACCAGAAGCATTTCTTTATTATTATTA
TTTTTTAACCTGGACATGCATTAAAGGGTCTATTAGCTTTCTTTCCGTCTGTCTCAACAGCTGAGATGGGGCCGCCAAGGAGTGCCTTCC
TTTTGCTCCCTCCTAGCTGGGAGTGACGGGTGGGAGTGTGTGTGCCCAGGTGGGGGTGTCTCCTGGCTGGGAAGGAGGGAAAGGGAGGGA
GAGTTTTGCGGGGGTTGGCAGTGGAGAGCAGGCTGGAGAGGAGATGGCTAATAGCTGTTTAATGGAAACCTGCTGGGCTGGAGGGAGTTA
GGCTGAATTTCCCGACTTCCTCTGCCAGTTATTGACACAGCTCTCTTTGTAAGAGAGGAAAGAAACTAAACCCACCCAAGGGATGATGTC
AGGGGGAGAGGTGGAGGGCAGATGTCCTGGGCAAACCGGGCCCCTCTGCCCACACACCTCACTTGATCCTTTTGCCAAACTTGTCAAACT
CAGGGGAACTGGCTTCCCAGTTGCCCCTTTGCCATATTCCAAGTCCCCCTCAGACTTCATGTCTCTGCTCATCAGCACTGTCCCAGGATC
CTGGAGAGGGAGAACTCCTGGCCCCAGGGGAAAGAGGGGGGGGTCTCCCGTTTCCTGTGCCTGCACCAGCCCTGCCCCCATTGCGTCTGC

>70905_70905_3_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000317479_SLC44A2_chr19_10746999_ENST00000586078_length(amino acids)=488AA_BP=389
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKTFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSA
FGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFL
LMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFCE

--------------------------------------------------------------
>70905_70905_4_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000428960_SLC44A2_chr19_10746999_ENST00000335757_length(transcript)=2408nt_BP=346nt
GCGGAAAAAAGAAAACTCTAGAAGTCTGGATGTCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCA
CTTCTTCTACTTCTTCATGGAACATTGGATCCCTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGC
ACCGGCCTTCCTCATGTTGTTCTTCCTCATCATGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTT
CTGGCCGGCGCTGAGGATGAACTGGCGGGTGTGGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGACCTTCCCCTCCTC
CAATGAGTCCCGCCAATGCCCCAATGCCCGTTGCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTGCTGGGCCTGCA
GATCTTCAATGCCTTCATGTTCTTCTGGTTGGCCAACTTCGTGCTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTA
CTGGGCCCTGCGCAAGCCGGACGACCTGCCGGCCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACAGGCTCCCTGGC
CTTTGGCGCGCTCATCCTGGCCATTGTGCAGATCATCCGTGTGATACTCGAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTT
TGCCAAGTGCCTCATGACCTGTCTCAAATGCTGCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCCTACATCATGAT
TGCCATCTACGGCACCAATTTCTGCACCTCGGCCAGGAATGCCTTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAA
AGTTACTGACTTCCTCTTCCTGTTGGGCAAACTTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACCCACCGTATCAG
GATCGTGCAGGATACAGCACCACCCCTCAATTATTACTGGGTTCCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTT
CTTCAGCGTCTATGGCATGTGTGTGGACACGCTGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGCTCGGCCGAGAGGCCTTA
CTTCATGTCTTCCACCCTCAAGAAACTCTTGAACAAGACCAACAAGAAGGCAGCGGAGTCCTGAAGGCCCCGTGCTCCCCACCTCTCAAG
GAGTCTCATGCCGCAGGGTGCTCAGTAGCTGGGTCTGTTCCCCCAGCCCCTTGGGCTCACCTGAAGTCCTATCACTGCCGCTCTGCCCCT
CCCCATGAGCCAGATCCCACCAGTTTCTGGACGTGGAGAGTCTGGGGCATCTCCTTCTTATGCCAAGGGGCGCTTGGAGTTTTCATGGCT
GCCCCTCCAGACTGCGAGAAACAAGTAAAAACCCATTGGGGCCTCTTGATGTCTGGGATGGCACGTGGCCCGACCTCCACAAGCTCCCTC
ATGCTTCCTGTCCCCCGCTTACACGACAACGGGCCAGACCACAGGAAGGACGGTGTTTGTGTCTGAGGGAGCTGCTGGCCACAGTGAACA
CCCACGTTTATTCCTGCCTGCTCCGGCCAGGACTGAACCCCTTCTCCACACCTGAACAGTTGGCTCAAGGGCCACCAGAAGCATTTCTTT
ATTATTATTATTTTTTAACCTGGACATGCATTAAAGGGTCTATTAGCTTTCTTTCCGTCTGTCTCAACAGCTGAGATGGGGCCGCCAAGG
AGTGCCTTCCTTTTGCTCCCTCCTAGCTGGGAGTGACGGGTGGGAGTGTGTGTGCCCAGGTGGGGGTGTCTCCTGGCTGGGAAGGAGGGA
AAGGGAGGGAGAGTTTTGCGGGGGTTGGCAGTGGAGAGCAGGCTGGAGAGGAGATGGCTAATAGCTGTTTAATGGAAACCTGCTGGGCTG
GAGGGAGTTAGGCTGAATTTCCCGACTTCCTCTGCCAGTTATTGACACAGCTCTCTTTGTAAGAGAGGAAAGAAACTAAACCCACCCAAG
GGATGATGTCAGGGGGAGAGGTGGAGGGCAGATGTCCTGGGCAAACCGGGCCCCTCTGCCCACACACCTCACTTGATCCTTTTGCCAAAC
TTGTCAAACTCAGGGGAACTGGCTTCCCAGTTGCCCCTTTGCCATATTCCAAGTCCCCCTCAGACTTCATGTCTCTGCTCATCAGCACTG
TCCCAGGATCCTGGAGAGGGAGAACTCCTGGCCCCAGGGGAAAGAGGGGGGGGTCTCCCGTTTCCTGTGCCTGCACCAGCCCTGCCCCCA

>70905_70905_4_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000428960_SLC44A2_chr19_10746999_ENST00000335757_length(amino acids)=402AA_BP=308
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKTFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDD
LPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFC
TSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCV

--------------------------------------------------------------
>70905_70905_5_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000428960_SLC44A2_chr19_10746999_ENST00000407327_length(transcript)=2399nt_BP=346nt
GCGGAAAAAAGAAAACTCTAGAAGTCTGGATGTCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCA
CTTCTTCTACTTCTTCATGGAACATTGGATCCCTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGC
ACCGGCCTTCCTCATGTTGTTCTTCCTCATCATGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTT
CTGGCCGGCGCTGAGGATGAACTGGCGGGTGTGGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGACCTTCCCCTCCTC
CAATGAGTCCCGCCAATGCCCCAATGCCCGTTGCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTGCTGGGCCTGCA
GATCTTCAATGCCTTCATGTTCTTCTGGTTGGCCAACTTCGTGCTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTA
CTGGGCCCTGCGCAAGCCGGACGACCTGCCGGCCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACAGGCTCCCTGGC
CTTTGGCGCGCTCATCCTGGCCATTGTGCAGATCATCCGTGTGATACTCGAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTT
TGCCAAGTGCCTCATGACCTGTCTCAAATGCTGCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCCTACATCATGAT
TGCCATCTACGGCACCAATTTCTGCACCTCGGCCAGGAATGCCTTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAA
AGTTACTGACTTCCTCTTCCTGTTGGGCAAACTTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACCCACCGTATCAG
GATCGTGCAGGATACAGCACCACCCCTCAATTATTACTGGGTTCCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTT
CTTCAGCGTCTATGGCATGTGTGTGGACACGCTGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGCTCGGCCGAGAGGCCTTA
CTTCATGTCTTCCACCCTCAAGAAACTCTTGAACAAGACCAACAAGAAGGCAGCGGAGTCCTGAAGGCCCCGTGCTCCCCACCTCTCAAG
GAGTCTCATGCCGCAGGGTGCTCAGTAGCTGGGTCTGTTCCCCCAGCCCCTTGGGCTCACCTGAAGTCCTATCACTGCCGCTCTGCCCCT
CCCCATGAGCCAGATCCCACCAGTTTCTGGACGTGGAGAGTCTGGGGCATCTCCTTCTTATGCCAAGGGGCGCTTGGAGTTTTCATGGCT
GCCCCTCCAGACTGCGAGAAACAAGTAAAAACCCATTGGGGCCTCTTGATGTCTGGGATGGCACGTGGCCCGACCTCCACAAGCTCCCTC
ATGCTTCCTGTCCCCCGCTTACACGACAACGGGCCAGACCACAGGAAGGACGGTGTTTGTGTCTGAGGGAGCTGCTGGCCACAGTGAACA
CCCACGTTTATTCCTGCCTGCTCCGGCCAGGACTGAACCCCTTCTCCACACCTGAACAGTTGGCTCAAGGGCCACCAGAAGCATTTCTTT
ATTATTATTATTTTTTAACCTGGACATGCATTAAAGGGTCTATTAGCTTTCTTTCCGTCTGTCTCAACAGCTGAGATGGGGCCGCCAAGG
AGTGCCTTCCTTTTGCTCCCTCCTAGCTGGGAGTGACGGGTGGGAGTGTGTGTGCCCAGGTGGGGGTGTCTCCTGGCTGGGAAGGAGGGA
AAGGGAGGGAGAGTTTTGCGGGGGTTGGCAGTGGAGAGCAGGCTGGAGAGGAGATGGCTAATAGCTGTTTAATGGAAACCTGCTGGGCTG
GAGGGAGTTAGGCTGAATTTCCCGACTTCCTCTGCCAGTTATTGACACAGCTCTCTTTGTAAGAGAGGAAAGAAACTAAACCCACCCAAG
GGATGATGTCAGGGGGAGAGGTGGAGGGCAGATGTCCTGGGCAAACCGGGCCCCTCTGCCCACACACCTCACTTGATCCTTTTGCCAAAC
TTGTCAAACTCAGGGGAACTGGCTTCCCAGTTGCCCCTTTGCCATATTCCAAGTCCCCCTCAGACTTCATGTCTCTGCTCATCAGCACTG
TCCCAGGATCCTGGAGAGGGAGAACTCCTGGCCCCAGGGGAAAGAGGGGGGGGTCTCCCGTTTCCTGTGCCTGCACCAGCCCTGCCCCCA

>70905_70905_5_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000428960_SLC44A2_chr19_10746999_ENST00000407327_length(amino acids)=402AA_BP=308
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKTFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDD
LPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFC
TSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCV

--------------------------------------------------------------
>70905_70905_6_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000428960_SLC44A2_chr19_10746999_ENST00000586078_length(transcript)=2788nt_BP=346nt
GCGGAAAAAAGAAAACTCTAGAAGTCTGGATGTCGGTGGGCCTCTGAGATATGCCGTTTACGGGTTCTTCTTCACAGGGCCGCTGAGTCA
CTTCTTCTACTTCTTCATGGAACATTGGATCCCTCCTGAGGTCCCCCTGGCAGGGCTCAGGAGGCTTCTCCTGGACCGCCTCGTCTTTGC
ACCGGCCTTCCTCATGTTGTTCTTCCTCATCATGAACTTTCTGGAGGGGAAAGACGCCTCAGCCTTCGCCGCCAAGATGAGGGGGGGCTT
CTGGCCGGCGCTGAGGATGAACTGGCGGGTGTGGACGCCACTACAGTTCATCAACATCAACTACGTCCCTCTGAAGACCTTCCCCTCCTC
CAATGAGTCCCGCCAATGCCCCAATGCCCGTTGCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTGCTGGGCCTGCA
GATCTTCAATGCCTTCATGTTCTTCTGGTTGGCCAACTTCGTGCTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTA
CTGGGCCCTGCGCAAGCCGGACGACCTGCCGGCCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACAGGCTCCCTGGC
CTTTGGCGCGCTCATCCTGGCCATTGTGCAGATCATCCGTGTGATACTCGAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTT
TGCCAAGTGCCTCATGACCTGTCTCAAATGCTGCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCCTACATCATGAT
TGCCATCTACGGCACCAATTTCTGCACCTCGGCCAGGAATGCCTTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAA
AGTTACTGACTTCCTCTTCCTGTTGGGCAAACTTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACCCACCGTATCAG
GATCGTGCAGGATACAGCACCACCCCTCAATTATTACTGGGTTCCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTT
CTTCAGCGTCTATGGCATGTGTGTGGACACGCTGTTCCTCTGCTTCTGTGAGGACCTGGAAAGGAATGACGGCTCTCAGGAGCGACCCTA
CTTCATGTCGCCCGAGCTGAGAGACATCCTGTTGAAGGGGAGTGCGGAGGAGGGGAAGCGGGCAGAAGCCGAGGAGTAGAGAGTGAGGGA
GACTGGCGTGGGGGCCAGGTTTCCTCCATGTAGACTGGGGGTGCATGAAGCGGGGGGGTTCCTGGCCTGCGAGTGTGGGGATCCTGTGTG
TCCCTCGGAGCCCACTACAGTCTGCCCCTCTCTGGTCCCAGTGTGTCTGCTTTCTAACCCTCTGAGGCTTCTCTGTGACCCTCATCCACC
TACCCTGTCCTTGAGGCCCCTGCCCGTGGGCTCCCCTCATGCCTCCTGCTCTGGGACCTCTCTCCACAGTGGAGGACCTGGAGAGGAATG
ACGGCTCGGCCGAGAGGCCTTACTTCATGTCTTCCACCCTCAAGAAACTCTTGAACAAGACCAACAAGAAGGCAGCGGAGTCCTGAAGGC
CCCGTGCTCCCCACCTCTCAAGGAGTCTCATGCCGCAGGGTGCTCAGTAGCTGGGTCTGTTCCCCCAGCCCCTTGGGCTCACCTGAAGTC
CTATCACTGCCGCTCTGCCCCTCCCCATGAGCCAGATCCCACCAGTTTCTGGACGTGGAGAGTCTGGGGCATCTCCTTCTTATGCCAAGG
GGCGCTTGGAGTTTTCATGGCTGCCCCTCCAGACTGCGAGAAACAAGTAAAAACCCATTGGGGCCTCTTGATGTCTGGGATGGCACGTGG
CCCGACCTCCACAAGCTCCCTCATGCTTCCTGTCCCCCGCTTACACGACAACGGGCCAGACCACAGGAAGGACGGTGTTTGTGTCTGAGG
GAGCTGCTGGCCACAGTGAACACCCACGTTTATTCCTGCCTGCTCCGGCCAGGACTGAACCCCTTCTCCACACCTGAACAGTTGGCTCAA
GGGCCACCAGAAGCATTTCTTTATTATTATTATTTTTTAACCTGGACATGCATTAAAGGGTCTATTAGCTTTCTTTCCGTCTGTCTCAAC
AGCTGAGATGGGGCCGCCAAGGAGTGCCTTCCTTTTGCTCCCTCCTAGCTGGGAGTGACGGGTGGGAGTGTGTGTGCCCAGGTGGGGGTG
TCTCCTGGCTGGGAAGGAGGGAAAGGGAGGGAGAGTTTTGCGGGGGTTGGCAGTGGAGAGCAGGCTGGAGAGGAGATGGCTAATAGCTGT
TTAATGGAAACCTGCTGGGCTGGAGGGAGTTAGGCTGAATTTCCCGACTTCCTCTGCCAGTTATTGACACAGCTCTCTTTGTAAGAGAGG
AAAGAAACTAAACCCACCCAAGGGATGATGTCAGGGGGAGAGGTGGAGGGCAGATGTCCTGGGCAAACCGGGCCCCTCTGCCCACACACC
TCACTTGATCCTTTTGCCAAACTTGTCAAACTCAGGGGAACTGGCTTCCCAGTTGCCCCTTTGCCATATTCCAAGTCCCCCTCAGACTTC
ATGTCTCTGCTCATCAGCACTGTCCCAGGATCCTGGAGAGGGAGAACTCCTGGCCCCAGGGGAAAGAGGGGGGGGTCTCCCGTTTCCTGT

>70905_70905_6_PXMP2-SLC44A2_PXMP2_chr12_133277955_ENST00000428960_SLC44A2_chr19_10746999_ENST00000586078_length(amino acids)=407AA_BP=308
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKTFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDD
LPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFC
TSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCV

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Fusion Gene PPI Analysis for PXMP2-SLC44A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PXMP2-SLC44A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PXMP2-SLC44A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource