FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PYCR1-BRI3BP (FusionGDB2 ID:70925)

Fusion Gene Summary for PYCR1-BRI3BP

check button Fusion gene summary
Fusion gene informationFusion gene name: PYCR1-BRI3BP
Fusion gene ID: 70925
HgeneTgene
Gene symbol

PYCR1

BRI3BP

Gene ID

5831

140707

Gene namepyrroline-5-carboxylate reductase 1BRI3 binding protein
SynonymsARCL2B|ARCL3B|P5C|P5CR|PIG45|PP222|PRO3|PYCRBNAS1|HCCR-1|HCCR-2|HCCRBP-1|HCCRBP-3|KG19
Cytomap

17q25.3

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionpyrroline-5-carboxylate reductase 1, mitochondrialP5C reductase 1proliferation-inducing protein 45BRI3-binding proteinI3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding protein
Modification date2020031320200313
UniProtAcc.

Q8WY22

Ensembl transtripts involved in fusion geneENST00000402252, ENST00000329875, 
ENST00000337943, ENST00000403172, 
ENST00000577756, 
ENST00000341446, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 8 X 4=256
# samples 39
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PYCR1 [Title/Abstract] AND BRI3BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPYCR1(79894624)-BRI3BP(125497080), # samples:3
Anticipated loss of major functional domain due to fusion event.PYCR1-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PYCR1-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePYCR1

GO:0006561

proline biosynthetic process

16730026


check buttonFusion gene breakpoints across PYCR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRI3BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6B9-01APYCR1chr17

79894624

-BRI3BPchr12

125497080

+


Top

Fusion Gene ORF analysis for PYCR1-BRI3BP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000402252ENST00000341446PYCR1chr17

79894624

-BRI3BPchr12

125497080

+
In-frameENST00000329875ENST00000341446PYCR1chr17

79894624

-BRI3BPchr12

125497080

+
In-frameENST00000337943ENST00000341446PYCR1chr17

79894624

-BRI3BPchr12

125497080

+
In-frameENST00000403172ENST00000341446PYCR1chr17

79894624

-BRI3BPchr12

125497080

+
In-frameENST00000577756ENST00000341446PYCR1chr17

79894624

-BRI3BPchr12

125497080

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000329875PYCR1chr1779894624-ENST00000341446BRI3BPchr12125497080+647613287674195
ENST00000337943PYCR1chr1779894624-ENST00000341446BRI3BPchr12125497080+68545104651052195
ENST00000403172PYCR1chr1779894624-ENST00000341446BRI3BPchr12125497080+6525181136723195
ENST00000577756PYCR1chr1779894624-ENST00000341446BRI3BPchr12125497080+646612277664195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000329875ENST00000341446PYCR1chr1779894624-BRI3BPchr12125497080+0.0168373830.98316264
ENST00000337943ENST00000341446PYCR1chr1779894624-BRI3BPchr12125497080+0.017748440.9822515
ENST00000403172ENST00000341446PYCR1chr1779894624-BRI3BPchr12125497080+0.0172008420.98279923
ENST00000577756ENST00000341446PYCR1chr1779894624-BRI3BPchr12125497080+0.0169723370.9830277

Top

Fusion Genomic Features for PYCR1-BRI3BP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PYCR1chr1779894623-BRI3BPchr12125497079+0.0012230020.998777
PYCR1chr1779894623-BRI3BPchr12125497079+0.0012230020.998777

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for PYCR1-BRI3BP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79894624/chr12:125497080)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRI3BP

Q8WY22

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in tumorigenesis and may function by stabilizing p53/TP53. {ECO:0000269|PubMed:17943721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePYCR1chr17:79894624chr12:125497080ENST00000329875-176_1122320.0Nucleotide bindingNADP
HgenePYCR1chr17:79894624chr12:125497080ENST00000337943-186_1122317.0Nucleotide bindingNADP
TgeneBRI3BPchr17:79894624chr12:125497080ENST0000034144603217_24771252.0Coiled coilOntology_term=ECO:0000255
TgeneBRI3BPchr17:79894624chr12:125497080ENST0000034144603125_14571252.0TransmembraneHelical
TgeneBRI3BPchr17:79894624chr12:125497080ENST0000034144603146_16671252.0TransmembraneHelical
TgeneBRI3BPchr17:79894624chr12:125497080ENST0000034144603185_20571252.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePYCR1chr17:79894624chr12:125497080ENST00000329875-1769_7222320.0Nucleotide bindingNADP
HgenePYCR1chr17:79894624chr12:125497080ENST00000329875-1795_9722320.0Nucleotide bindingNADP
HgenePYCR1chr17:79894624chr12:125497080ENST00000337943-1869_7222317.0Nucleotide bindingNADP
HgenePYCR1chr17:79894624chr12:125497080ENST00000337943-1895_9722317.0Nucleotide bindingNADP
TgeneBRI3BPchr17:79894624chr12:125497080ENST000003414460313_3371252.0TransmembraneHelical


Top

Fusion Gene Sequence for PYCR1-BRI3BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>70925_70925_1_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000329875_BRI3BP_chr12_125497080_ENST00000341446_length(transcript)=6476nt_BP=132nt
GCCGGTCTCGTCCCGCAGAGCCGGTGCCATCTGTGGGGGCTTTGGGCCAGGGGTCTCCGGACAGCATGAGCGTGGGCTTCATCGGCGCTG
GCCAGCTGGCTTTTGCCCTGGCCAAGGGCTTCACAGCAGCAGTTCTTGGCCAGGCTGACTGAGAGATTTGTGCTGGGAGTGGATATGTTC
GTGGAGACACTGTGGAAAGTCTGGACCGAGCTCTTGGATGTTCTTGGACTTGACGTCTCCAACCTGTCCCAGTATTTCAGCCCAGCCTCG
GTGTCCAGCAGCCCGGCCCGCGCGCTCCTGCTGGTCGGCGTCGTCCTCCTGGCCTACTGGTTCTTGTCCCTGACCCTGGGCTTCACTTTC
AGCGTCCTGCACGTGGTGTTCGGCCGCTTCTTCTGGATCGTGCGGGTCGTCCTGTTTTCCATGTCCTGCGTGTACATCCTGCACAAGTAC
GAGGGCGAGCCGGAGAACGCGGTGCTGCCGCTGTGCTTCGTGGTGGCCGTCTACTTCATGACCGGGCCCATGGGCTTCTACTGGCGAAGC
AGTCCCAGCGGCCCCAGCAACCCCAGCAACCCCAGCGTGGAGGAGAAGCTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGT
CTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTC
AGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATT
TCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGG
AAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTT
CAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATG
CTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCAT
GTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGG
GCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTT
CTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAA
TGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCAC
TAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCA
GCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTT
TTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGAC
TTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACT
TGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCT
GAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGT
GCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTG
CACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCAC
GACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCC
AGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAG
TTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTAC
ACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGG
ATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGA
GGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCC
TGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACA
CTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGT
CAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAG
TAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGT
CTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAA
TCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAG
CACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTG
CTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATT
GTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACAT
GAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGG
TGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAG
CCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAA
ATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTC
ACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTG
GGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGG
AGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTG
GTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTAC
TGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGAT
CTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTT
GTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTC
TCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAG
GTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCC
AGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTA
CCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACC
TTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTG
TCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCC
TCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTG
TAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGA
CATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGT
CATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTA
TCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAA
CATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACC
CTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTT
GCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGA
AAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATC
TGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGA
AGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTT
TGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTG
TGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTT
TGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAA

>70925_70925_1_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000329875_BRI3BP_chr12_125497080_ENST00000341446_length(amino acids)=195AA_BP=14
MASWLLPWPRASQQQFLARLTERFVLGVDMFVETLWKVWTELLDVLGLDVSNLSQYFSPASVSSSPARALLLVGVVLLAYWFLSLTLGFT
FSVLHVVFGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRSSPSGPSNPSNPSVEEKLEHLEKQVRLLNI

--------------------------------------------------------------
>70925_70925_2_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000337943_BRI3BP_chr12_125497080_ENST00000341446_length(transcript)=6854nt_BP=510nt
GTACGACCCGCGCACGGTAGCTGGGTTGGGGTCGGGCTCCGGGAATGGTGGGCGGCGGTCGCCGGGTGGGGCGCGACGGTAGCCCAGTTC
TGGGCGGGGTGGGAACCCAGACGGGGGACCCCTAGGCGCCGGGCCCTCCCTCTCCCCGTACTTTTCCCCCTTCCCAGTCATTTCTTCTGC
GGAACCTCCACCCCTCCAGTGGGTGCGGGACCCTAGGCAGCAGGCCAGGCACCGCCGCTCTGACTGGGGGCCCCGAAGCAGTTAACGGGC
CGGACAGCAAAGTGGAAAGTTAGACCAGCTGGGACCAGGGGAGGTGGGCACCCGGCTGCGGGAGGAGCGGCCAGGCTGGCACTGCCCCCC
TAACTTGCTCTCGATCCTGCCGGTCTCGTCCCGCAGAGCCGGTGCCATCTGTGGGGGCTTTGGGCCAGGGGTCTCCGGACAGCATGAGCG
TGGGCTTCATCGGCGCTGGCCAGCTGGCTTTTGCCCTGGCCAAGGGCTTCACAGCAGCAGTTCTTGGCCAGGCTGACTGAGAGATTTGTG
CTGGGAGTGGATATGTTCGTGGAGACACTGTGGAAAGTCTGGACCGAGCTCTTGGATGTTCTTGGACTTGACGTCTCCAACCTGTCCCAG
TATTTCAGCCCAGCCTCGGTGTCCAGCAGCCCGGCCCGCGCGCTCCTGCTGGTCGGCGTCGTCCTCCTGGCCTACTGGTTCTTGTCCCTG
ACCCTGGGCTTCACTTTCAGCGTCCTGCACGTGGTGTTCGGCCGCTTCTTCTGGATCGTGCGGGTCGTCCTGTTTTCCATGTCCTGCGTG
TACATCCTGCACAAGTACGAGGGCGAGCCGGAGAACGCGGTGCTGCCGCTGTGCTTCGTGGTGGCCGTCTACTTCATGACCGGGCCCATG
GGCTTCTACTGGCGAAGCAGTCCCAGCGGCCCCAGCAACCCCAGCAACCCCAGCGTGGAGGAGAAGCTGGAGCACCTGGAGAAGCAGGTC
AGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAG
TTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTG
GCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACTACACACG
AAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGA
GCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTAC
ATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTC
TGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTT
CTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAA
ATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCTCAACATTTTGAAACGGAAAATG
CAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCC
AATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAG
GGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTG
AAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCT
GTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAA
CCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCC
GAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAG
TCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGA
GCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTT
GAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGT
TTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTG
TGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGA
CTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATG
TTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAA
GGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCA
GGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGC
TGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTT
GAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTC
CTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCAC
CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCG
CGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTG
TAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTA
GGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCT
CCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCA
CCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAAC
ATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGC
TAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGG
TGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGG
TTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCT
TGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGT
ACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACACTTCACTGAATGTGACGTAAAA
GCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCAC
AGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGT
TGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGG
GTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCA
ACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCA
GCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGA
GGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATATATATACACACACACACACTTTC
CAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGA
ATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTAC
CCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAA
CCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTATAATATGACTTTGTGCATG
CCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACA
GCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAA
GATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAA
GCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAAT
GGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGTGAATAATAGGAATATATTTTGC
AGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGTAAACAAATTTTATTCAGCATAT
TAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCC
ATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTG
TAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTGTGATGGTGATGGTGATTAGCAC
ACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTC
ATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATATAAATCCATTTGATTTGAATAGT
GTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAATATCTTATATAGAGATAA
ATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGA
TCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATTTTGTTGTATGGACTTTTAAAATATATCTCAT

>70925_70925_2_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000337943_BRI3BP_chr12_125497080_ENST00000341446_length(amino acids)=195AA_BP=14
MASWLLPWPRASQQQFLARLTERFVLGVDMFVETLWKVWTELLDVLGLDVSNLSQYFSPASVSSSPARALLLVGVVLLAYWFLSLTLGFT
FSVLHVVFGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRSSPSGPSNPSNPSVEEKLEHLEKQVRLLNI

--------------------------------------------------------------
>70925_70925_3_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000403172_BRI3BP_chr12_125497080_ENST00000341446_length(transcript)=6525nt_BP=181nt
GGATTCGCTGGCGCGACGGGGGCGGGGCCTGGGTGCGGGTGCCGCGTGGCGGCCGCAGCGCTGAGGGAGCCGGTGCCATCTGTGGGGGCT
TTGGGCCAGGGGTCTCCGGACAGCATGAGCGTGGGCTTCATCGGCGCTGGCCAGCTGGCTTTTGCCCTGGCCAAGGGCTTCACAGCAGCA
GTTCTTGGCCAGGCTGACTGAGAGATTTGTGCTGGGAGTGGATATGTTCGTGGAGACACTGTGGAAAGTCTGGACCGAGCTCTTGGATGT
TCTTGGACTTGACGTCTCCAACCTGTCCCAGTATTTCAGCCCAGCCTCGGTGTCCAGCAGCCCGGCCCGCGCGCTCCTGCTGGTCGGCGT
CGTCCTCCTGGCCTACTGGTTCTTGTCCCTGACCCTGGGCTTCACTTTCAGCGTCCTGCACGTGGTGTTCGGCCGCTTCTTCTGGATCGT
GCGGGTCGTCCTGTTTTCCATGTCCTGCGTGTACATCCTGCACAAGTACGAGGGCGAGCCGGAGAACGCGGTGCTGCCGCTGTGCTTCGT
GGTGGCCGTCTACTTCATGACCGGGCCCATGGGCTTCTACTGGCGAAGCAGTCCCAGCGGCCCCAGCAACCCCAGCAACCCCAGCGTGGA
GGAGAAGCTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGGTGCTCGAGAGCCTGGACCGCTCCAAGGACAA
GTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAAAACGGAGGAAAAAAACCCCAAACCCCAAACA
ATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACCCGGCAGCTCTTAGGACACATTCCCAGAAGAG
CGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATTTTTTAAACAAAGGATATAACCATATTTAGTT
GTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTAAATACATCTTTTGTAAGGTTTTTTAATAAAG
GCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGACATTTGAGAAAAGTTTAAATGCGAGCGTTTGT
TTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAACTGTGAGCTTTATTTCATGTTATTTTTGGTGG
ATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGATGCAACTCAACCTCTTTTGGATCCTAGAGACC
CCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACCTGAGATTTTCTTCCCTCTGTGCTTCGATGTA
TTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGGATTTGATGCCAGGAAGTACCTGGTAAGGATT
GGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATATACAAAAGCTATACCCTTGAGGGTTTTTTTT
TTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTCTCAAGTATATTGCTGCTTAGAAAGATCCTCA
GGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAATATTTACGATACACAGGTGCTTTTTATCTGAA
ATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTGGACAGCTGTGGGGATCCTGGGCAAGGGAGTT
TCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAAAAAAGAAAGCCCTAGGCCAGGCGCAGTGGCT
GATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAA
CCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATT
GCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTAGGCAACAGAGCAAGACTTCATCTTAAAAA
AAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCTGTGGCCCTTACCTGGCCACAGATGTACCCTG
GCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTACAACCAAGACCTTATGGTCCAGGTCTCAGTT
TGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTTGGTTGCAAGTATCTGGAAAACAGATGCAGAT
GTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGGACCCAAACTCTCCTGGAGAGTTCCATTCACT
TCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGATTTGCTGGAGCAGGCTGGGCAGGGTGGCTCA
CCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCCGGCCAACAGAGTGAAACC
CCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGC
TTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTCAGCAACAGAGTGAGACTCCGTCTCAAAAAAA
ATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGC
AAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGACTACAGGCGCCCACCATCATGCCCGGCTAATT
TTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCC
AAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCATGCACATTGGAACACAGGATTACTGGGTTGA
AATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTATAAATAACTCGGGAGGTCATCTCTATCTTCTT
TCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGGCCAGGGGAAAACATGGCATTCTGTGCGCAAA
GCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCCCGCATGTTAAGGCTTAAGCTGTCACTGGGCT
GGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACTGTGCTCTATTGAGATCTCGATAAGATCATCA
TTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGACCTCAAGCATCAATTCAAAATTGCTGTCGAA
AATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTATAGCTTGATACATTCTGGTGAAAGATGTCTTC
ATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAGAAATTCTGATTATTTGAAACTCTGATAGAAA
TCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTGGGGCACATCTTACCCCAAAATAATTGGGGAT
TTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCTCGCCACCCGCCACATGTCTTTGTTTTTTTCT
CTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCTTTTTTCTATCTTCAGGGCTGTAGAATATATT
AGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTATAATTAAGACTCAGTGTTTAAAATATCTTAAT
CAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGAAAATAATCCAGAAAAGGAAAAGGACCAGCCC
TCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTGACACCCTAGCAAAGATGCTTTTGTGGAGTGC
AAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACT
TGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAAAATACAAAAAAAAAAAAAAAAAAAAAAATAG
CCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAATTGTATGAACCTGGGAGGCAGAGGTTGCAGTG
AACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAAAAAAAAAAAAGTGTGTGTGTGTGTATATATA
TGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTTGGTTTCTTTTGCTTTGGATTTCAGCCCCCAT
ATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCGTGCCTGTGTCTTAATTCACAAAGGGTAAGTG
AATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAGGAGTCGGGAGGCAGCGATGTCAGGGAACTGG
GACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGCTGAGTAAGAACGCAAAGGTTTGGGTCAGTGA
TTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGATGTGAGCAGCTTAGTCGCTCATCTGGCCCTGT
GATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAATGCAATTTGTTGCTAGTGGAAATCCTGAATTG
CTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTTACAAGTTGACACCTGATAACTTCTCCCTGAT
GGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTAAAAGGAATTCCTGAGGCTCCTAAGGGGTCAG
CTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTTTATGGCCATTTGAATAGTTGGACTTTGACTC
CTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTCATACTGGACAACCATCAGTGTGATGTATAGT
ATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTTGATATGTAGGAGGTGCACCAGTACCAGTTTT
TCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGGCAGCGAGTGGTATTATTGACCATGTGTTCTC
ATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTGTTTAATCTCTGAATACCATGTAATTAAACTG
ATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTCTCCCTCTTCTTAACTGGAAATCACACTTGTG
AGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTGGTTATAAATTTTGTATAGCATTTAATTTGGC
ACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTGTGTGCACTTTAGTTTCGTGAGCCTTGGGAAA
CTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGATATATACATTCCTCTTATTTATTAAATCACT
GGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAAAATTACAGCTTAATAAATGTTTATTGTAATT

>70925_70925_3_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000403172_BRI3BP_chr12_125497080_ENST00000341446_length(amino acids)=195AA_BP=14
MASWLLPWPRASQQQFLARLTERFVLGVDMFVETLWKVWTELLDVLGLDVSNLSQYFSPASVSSSPARALLLVGVVLLAYWFLSLTLGFT
FSVLHVVFGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRSSPSGPSNPSNPSVEEKLEHLEKQVRLLNI

--------------------------------------------------------------
>70925_70925_4_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000577756_BRI3BP_chr12_125497080_ENST00000341446_length(transcript)=6466nt_BP=122nt
TCCCGCAGAGCCGGTGCCATCTGTGGGGGCTTTGGGCCAGGGGTCTCCGGACAGCATGAGCGTGGGCTTCATCGGCGCTGGCCAGCTGGC
TTTTGCCCTGGCCAAGGGCTTCACAGCAGCAGTTCTTGGCCAGGCTGACTGAGAGATTTGTGCTGGGAGTGGATATGTTCGTGGAGACAC
TGTGGAAAGTCTGGACCGAGCTCTTGGATGTTCTTGGACTTGACGTCTCCAACCTGTCCCAGTATTTCAGCCCAGCCTCGGTGTCCAGCA
GCCCGGCCCGCGCGCTCCTGCTGGTCGGCGTCGTCCTCCTGGCCTACTGGTTCTTGTCCCTGACCCTGGGCTTCACTTTCAGCGTCCTGC
ACGTGGTGTTCGGCCGCTTCTTCTGGATCGTGCGGGTCGTCCTGTTTTCCATGTCCTGCGTGTACATCCTGCACAAGTACGAGGGCGAGC
CGGAGAACGCGGTGCTGCCGCTGTGCTTCGTGGTGGCCGTCTACTTCATGACCGGGCCCATGGGCTTCTACTGGCGAAGCAGTCCCAGCG
GCCCCAGCAACCCCAGCAACCCCAGCGTGGAGGAGAAGCTGGAGCACCTGGAGAAGCAGGTCAGACTGCTCAACATCCGTCTCAACCGGG
TGCTCGAGAGCCTGGACCGCTCCAAGGACAAGTGAAGGTCAGCCGGCCGGGCGGGTCCACAGTTACCAGCACGCTGTCTCAGAAAACGAA
AACGGAGGAAAAAAACCCCAAACCCCAAACAATCTTAATAAACACGACTGAGCAAGAAAGTGGCGCTGTGTAGGGCTATTTCCACCCACC
CGGCAGCTCTTAGGACACATTCCCAGAAGAGCGGAAAGATCATTGACGTGGAACTACACACGAAGTGTAATTAGTGGGGGAAAAAATATT
TTTTAAACAAAGGATATAACCATATTTAGTTGTACAGTAAGAGAAATTTATCTGTGCATAGAGCATAAAGTTAATTTTTTCAAGCATTTA
AATACATCTTTTGTAAGGTTTTTTAATAAAGGCAGATTGAGTCAAGTTTATTAAAACTTTACATGGAGGGGAAGAATATGCTAATTTGAC
ATTTGAGAAAAGTTTAAATGCGAGCGTTTGTTTTCACAGCTTAGGGATTGGTGGGTGAGGTCTGTGTGCGTTATTTTCATGTTCCCAAAC
TGTGAGCTTTATTTCATGTTATTTTTGGTGGATGTTGACTTAGTTCATGAATGTTGTCACTTCTAAATGTGGACAGTTGGGCTGCAGGAT
GCAACTCAACCTCTTTTGGATCCTAGAGACCCCTGCCAAGCCCCCATCAGTCCTATTTTTAAATGAAGACATCGCCATTTCTAGAAGACC
TGAGATTTTCTTCCCTCTGTGCTTCGATGTATTTTAACCTCAACATTTTGAAACGGAAAATGCAAGGAGGGGCCAAGAAATGTCCTGGGG
ATTTGATGCCAGGAAGTACCTGGTAAGGATTGGAGATTGCTCCAGAATCTACTGCATGTCCCAATTTGCAGTTTGCTCACTAGGGCTATA
TACAAAAGCTATACCCTTGAGGGTTTTTTTTTTTTTCTTTTGATTTCCTCAGGACCTTAGAGGGAAAACAAACAGTAGCAGCTAATATTC
TCAAGTATATTGCTGCTTAGAAAGATCCTCAGGAACAATTAGCAGCAATAAGCAAGCCTTTGAAAAGATCTGAATTCTTTTTCCTGAAAT
ATTTACGATACACAGGTGCTTTTTATCTGAAATCTGTTGTGTCCTCCTTTTAGGCAGTCTCTGTGGGCAGAGAGTGGGACTTGCGAGGTG
GACAGCTGTGGGGATCCTGGGCAAGGGAGTTTCAGAAGGTGTGGCTCAGGGGCTGGTAGAAACCCCCTTTTGTTAGGACTTGTTTTTTAA
AAAAGAAAGCCCTAGGCCAGGCGCAGTGGCTGATGCCTGTAATCCCAGCGCTTTGGGAGGCCGAGGAGTATGGATCACCTGAGGTCAGGA
GTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGCATGGTGGTGGGTGCCTGTAGTC
CAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCC
TAGGCAACAGAGCAAGACTTCATCTTAAAAAAAAAAAAAAAAGCCCAGCATTTTGCAGCTTTGAAGCTGCTGGGGATCACGACTGTCTCT
GTGGCCCTTACCTGGCCACAGATGTACCCTGGCAACCCGCTCACAGTGCCCTGCGTGCAGGTTTATAGATAACCCCTGCCAGACCTGCTA
CAACCAAGACCTTATGGTCCAGGTCTCAGTTTGGAGAAGATTTAGCTGTCTACCACTTCTTGTGTAGTGTTCCTGTGAAGTTTTATTTTT
GGTTGCAAGTATCTGGAAAACAGATGCAGATGTTTTTGTGGATGTTGTTGAGACTTTTGAGACTTCTGTTTCTAAGGTACACATGATGGG
ACCCAAACTCTCCTGGAGAGTTCCATTCACTTCCTGAAACGTGCACCTGTTTCAGGTGCATGTTTATTCAGTGTGCATGGATATTTAAGA
TTTGCTGGAGCAGGCTGGGCAGGGTGGCTCACCCCTATAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGT
TTGAGACCAGCCCGGCCAACAGAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGTGGGCGCCTGTGATCCCA
GCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACATGGGAGGCGGAGGTTGCAGTCAGCTGAGATCATACCACCACACTCTAGCCTC
AGCAACAGAGTGAGACTCCGTCTCAAAAAAAATTATTTGCTGGATCGAATCTTTTTTTTTTTGAGATGGAGTCTCACTGTCAACCAGGCT
GGAGTGCAGTGGCACCATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTACCTCAGCCTCCCAAGTAGCCGGGAC
TACAGGCGCCCACCATCATGCCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCC
TGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCTGGGCCTAGATCAAATCTTTATCCA
TGCACATTGGAACACAGGATTACTGGGTTGAAATCATTCTAGTTTTGTCATTTAGATACTTGTAGATGAATCTATTTTAGCACAAGGTAT
AAATAACTCGGGAGGTCATCTCTATCTTCTTTCCTTTTGTGCATTTGGCTATACCACGTTTAGGTACTAAAACAGCTTTGCTTATGTTGG
CCAGGGGAAAACATGGCATTCTGTGCGCAAAGCTAATGATCGCCAGCCCTGCCTTGGCCCCTCCCTTGTTTATGGTCATTGTAAGATGCC
CGCATGTTAAGGCTTAAGCTGTCACTGGGCTGGGTGTAATACCCGCTTCATTCCTCCTCCCACCCTCTTACCCGAAACATGAAGGGCACT
GTGCTCTATTGAGATCTCGATAAGATCATCATTTTAACTTGTATTCAACTGAGGGAGGTAACATGATATCTGGGTGCTGGTGGATTGAGA
CCTCAAGCATCAATTCAAAATTGCTGTCGAAAATATGCACTATTTTTTTTTTCCACTCTGGCTAAGTGTAGGCTCTGAAGCCAGTTTTAT
AGCTTGATACATTCTGGTGAAAGATGTCTTCATTTTTAATGAAAGAACCTACAGTTAGTAGGTGTCACCTCAGGGTAGAAATTCTGATAG
AAATTCTGATTATTTGAAACTCTGATAGAAATCCTAGATGCTAGATTTGAAGAAAACCTGGGTTTTATTGCATAGATTTCACCTTTTCTG
GGGCACATCTTACCCCAAAATAATTGGGGATTTTTTTGTTCCTTCTCCATTCCATGGAACCTTGTAGGGTGTTGGGATTGGGCCTCCCCT
CGCCACCCGCCACATGTCTTTGTTTTTTTCTCTCTTTTGTATGTGGAAAAATGTATTTTTGTACCATATCTCATACCTGGAGAGAAACCT
TTTTTCTATCTTCAGGGCTGTAGAATATATTAGCGTAACACTTCACTGAATGTGACGTAAAAGCATTCTGATGAAAACTGGTTCTGTTAT
AATTAAGACTCAGTGTTTAAAATATCTTAATCAGTGTTAATTTCCCAGTGTTTCAGTATCACAGTAAATACTTGTTTTACTGAGAACAGA
AAATAATCCAGAAAAGGAAAAGGACCAGCCCTCTCTAGATTGCTGGAATTGTATGGATGTGTTGGGGTTGGTTTAGTGATCTCTTCCTTG
ACACCCTAGCAAAGATGCTTTTGTGGAGTGCAAACCTTTCATAAATATACTTTCCAGGCTGGGTGCAGTGGCTCAAGCTTGTAATCCCAG
CACTTTGGGAGGCCAAGGCGGGTGGATCACTTGCGGTCGGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAATCCCGTCTCTACCAAAA
AATACAAAAAAAAAAAAAAAAAAAAAAATAGCCAGGTGTGGTGGTGGGTTCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGAAT
TGTATGAACCTGGGAGGCAGAGGTTGCAGTGAACTGAGATCACACCACTGTACTCCAGTTGAGGCGACAGAGTGAGACCCAGTCTCAAAA
AAAAAAAAAAGTGTGTGTGTGTGTATATATATGTATATATATATACACACACACACACTTTCCAATACCAGTCGGCATTACCCGCCCTTT
GGTTTCTTTTGCTTTGGATTTCAGCCCCCATATCATTTCTGGTAACAGAGCACAGCAATAGAATTTCTGGGAAGCAGACCTTGTGAATCG
TGCCTGTGTCTTAATTCACAAAGGGTAAGTGAATGCCGTTGAAAGGTGTTTCATACACTTACCCCAGAAATGAGAGCCTGTCTCATGCAG
GAGTCGGGAGGCAGCGATGTCAGGGAACTGGGACTATGTCTTTATGACTGTGATGGTGGTAACCAAGTGGGGTGGTCCCCTCTGGGGAGC
TGAGTAAGAACGCAAAGGTTTGGGTCAGTGATTAGGAAGACTATAATATGACTTTGTGCATGCCCGGGAGGGCTGCCTTGTAGAGAGGAT
GTGAGCAGCTTAGTCGCTCATCTGGCCCTGTGATTCAGGCTTATGGAGCGTTAAGAATAACAGCTGTCAAATGGCCTAGACATGGTTAAT
GCAATTTGTTGCTAGTGGAAATCCTGAATTGCTTCCTTTCTGTGATCACTGCTACTTCTTAAGATGCTTTTGATGAATGTCATCTGCCTT
ACAAGTTGACACCTGATAACTTCTCCCTGATGGGTTTCCGAACTGGCTGACTTAACCAAAAAGCCAGCTCTTGCCATCTATCTTGCATTA
AAAGGAATTCCTGAGGCTCCTAAGGGGTCAGCTGCCCCACTCCTGACTTTTTTATTTTTAATGGTCTATACCTTCTGCAACATTTTTGTT
TATGGCCATTTGAATAGTTGGACTTTGACTCCTCACTTGTGAATAATAGGAATATATTTTGCAGAATCTAACATAATACCCTTAAAATTC
ATACTGGACAACCATCAGTGTGATGTATAGTATCTGGTGTAAACAAATTTTATTCAGCATATTAAATTATTCTGTGTTTTGCTTTTCCTT
GATATGTAGGAGGTGCACCAGTACCAGTTTTTCTCTTGTGGTGGCTTAAAACGCTGATTGCCATTTGCATTGTCTACTGAAAAGCTGTGG
CAGCGAGTGGTATTATTGACCATGTGTTCTCATGTCTTTTTGCAGATTTAAAGGTTTTATTGTAGTGTCCATTTAATATCTGCATGTGTG
TTTAATCTCTGAATACCATGTAATTAAACTGATTAACTTGTGATGGTGATGGTGATTAGCACACACTAAAAACCCAATGAAGCAATTGTC
TCCCTCTTCTTAACTGGAAATCACACTTGTGAGGTATGGTATCCATTATCAACAGTGGATTCATGATTGACTTCATATTTTGTGTATCTG
GTTATAAATTTTGTATAGCATTTAATTTGGCACTTAATATAAATCCATTTGATTTGAATAGTGTGTGTGTGTACATGGTGTGTGTGTGTG
TGTGCACTTTAGTTTCGTGAGCCTTGGGAAACTGATTCTACAAATATCTTATATAGAGATAAATGTATCAGGCATTTTTTTGCAAAGCGA
TATATACATTCCTCTTATTTATTAAATCACTGGCTTTGGTGTTATGTAGAGATATTTGTAGATCTCAGAACAGAATTAAAATATTGTGAA

>70925_70925_4_PYCR1-BRI3BP_PYCR1_chr17_79894624_ENST00000577756_BRI3BP_chr12_125497080_ENST00000341446_length(amino acids)=195AA_BP=14
MASWLLPWPRASQQQFLARLTERFVLGVDMFVETLWKVWTELLDVLGLDVSNLSQYFSPASVSSSPARALLLVGVVLLAYWFLSLTLGFT
FSVLHVVFGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRSSPSGPSNPSNPSVEEKLEHLEKQVRLLNI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PYCR1-BRI3BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PYCR1-BRI3BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PYCR1-BRI3BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource