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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:QRICH1-FBXW12 (FusionGDB2 ID:71006)

Fusion Gene Summary for QRICH1-FBXW12

Fusion gene summary

Fusion gene information	Fusion gene name: QRICH1-FBXW12
	Fusion gene ID: 71006
		Hgene	Tgene
	Gene symbol	QRICH1	FBXW12
	Gene ID	54870	285231
	Gene name	glutamine rich 1	F-box and WD repeat domain containing 12
	Synonyms	AB-DIP\|VERBRAS	FBW12\|FBXO12\|FBXO35
	Cytomap	3p21.31	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	glutamine-rich protein 1	F-box/WD repeat-containing protein 12F-box and WD-40 domain protein 12F-box and WD-40 domain-containing protein 12F-box only protein 35F-box- and WD40-repeat-containing protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000357496, ENST00000395443, ENST00000424300, ENST00000479449,	ENST00000436231, ENST00000468158, ENST00000296438, ENST00000415155, ENST00000445170,
Fusion gene scores	* DoF score	19 X 13 X 10=2470	5 X 5 X 5=125
	# samples	20	8
	** MAII score	log2(20/2470*10)=-3.62643913669732 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/125*10)=-0.643856189774725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: QRICH1 [Title/Abstract] AND FBXW12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	QRICH1(49114141)-FBXW12(48414797), # samples:1 QRICH1(49114142)-FBXW12(48415038), # samples:1
Anticipated loss of major functional domain due to fusion event.	QRICH1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across QRICH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXW12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8364-01A	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
ChimerDB4	STAD	TCGA-BR-8364	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+

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Fusion Gene ORF analysis for QRICH1-FBXW12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000357496	ENST00000436231	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
5CDS-intron	ENST00000357496	ENST00000436231	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
5CDS-intron	ENST00000357496	ENST00000468158	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
5CDS-intron	ENST00000357496	ENST00000468158	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
5CDS-intron	ENST00000395443	ENST00000436231	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
5CDS-intron	ENST00000395443	ENST00000436231	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
5CDS-intron	ENST00000395443	ENST00000468158	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
5CDS-intron	ENST00000395443	ENST00000468158	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
5CDS-intron	ENST00000424300	ENST00000436231	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
5CDS-intron	ENST00000424300	ENST00000436231	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
5CDS-intron	ENST00000424300	ENST00000468158	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
5CDS-intron	ENST00000424300	ENST00000468158	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000357496	ENST00000296438	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000357496	ENST00000415155	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000357496	ENST00000445170	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000395443	ENST00000296438	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000395443	ENST00000415155	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000395443	ENST00000445170	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000424300	ENST00000296438	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000424300	ENST00000415155	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
Frame-shift	ENST00000424300	ENST00000445170	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
In-frame	ENST00000357496	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000357496	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000357496	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000395443	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000395443	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000395443	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000424300	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000424300	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
In-frame	ENST00000424300	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
intron-3CDS	ENST00000479449	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
intron-3CDS	ENST00000479449	ENST00000296438	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
intron-3CDS	ENST00000479449	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
intron-3CDS	ENST00000479449	ENST00000415155	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
intron-3CDS	ENST00000479449	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
intron-3CDS	ENST00000479449	ENST00000445170	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
intron-intron	ENST00000479449	ENST00000436231	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
intron-intron	ENST00000479449	ENST00000436231	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+
intron-intron	ENST00000479449	ENST00000468158	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+
intron-intron	ENST00000479449	ENST00000468158	QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395443	QRICH1	chr3	49114142	-	ENST00000296438	FBXW12	chr3	48415038	+	2115	782	672	2048	458
ENST00000395443	QRICH1	chr3	49114142	-	ENST00000415155	FBXW12	chr3	48415038	+	1867	782	672	1838	388
ENST00000395443	QRICH1	chr3	49114142	-	ENST00000445170	FBXW12	chr3	48415038	+	2077	782	672	2048	458
ENST00000357496	QRICH1	chr3	49114142	-	ENST00000296438	FBXW12	chr3	48415038	+	1874	541	431	1807	458
ENST00000357496	QRICH1	chr3	49114142	-	ENST00000415155	FBXW12	chr3	48415038	+	1626	541	431	1597	388
ENST00000357496	QRICH1	chr3	49114142	-	ENST00000445170	FBXW12	chr3	48415038	+	1836	541	431	1807	458
ENST00000424300	QRICH1	chr3	49114142	-	ENST00000296438	FBXW12	chr3	48415038	+	2080	747	637	2013	458
ENST00000424300	QRICH1	chr3	49114142	-	ENST00000415155	FBXW12	chr3	48415038	+	1832	747	637	1803	388
ENST00000424300	QRICH1	chr3	49114142	-	ENST00000445170	FBXW12	chr3	48415038	+	2042	747	637	2013	458

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395443	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.005827364	0.99417263
ENST00000395443	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.010679103	0.9893209
ENST00000395443	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.006578353	0.9934216
ENST00000357496	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.006014339	0.9939857
ENST00000357496	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.009073862	0.99092615
ENST00000357496	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.006820526	0.99317944
ENST00000424300	ENST00000296438	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.005359871	0.9946402
ENST00000424300	ENST00000415155	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.014411328	0.9855886
ENST00000424300	ENST00000445170	QRICH1	chr3	49114142	-	FBXW12	chr3	48415038	+	0.005714223	0.99428576

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Fusion Genomic Features for QRICH1-FBXW12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+	3.59E-09	1
QRICH1	chr3	49114141	-	FBXW12	chr3	48415037	+	2.56E-08	1
QRICH1	chr3	49114141	-	FBXW12	chr3	48414797	+	3.59E-09	1
QRICH1	chr3	49114141	-	FBXW12	chr3	48415037	+	2.56E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for QRICH1-FBXW12

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:49114141/chr3:48414797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

QRICH1

chr3:49114142

chr3:48415038

ENST00000357496

1_64

103

777.0

Domain

Note=CARD

Hgene

QRICH1

chr3:49114142

chr3:48415038

ENST00000395443

1_64

103

777.0

Domain

Note=CARD

Hgene

QRICH1

chr3:49114142

chr3:48415038

ENST00000424300

1_64

103

777.0

Domain

Note=CARD

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

136_174

465.0

Repeat

Note=WD 2

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

178_217

465.0

Repeat

Note=WD 3

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

222_263

465.0

Repeat

Note=WD 4

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

270_315

465.0

Repeat

Note=WD 5

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

320_367

465.0

Repeat

Note=WD 6

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

370_407

465.0

Repeat

Note=WD 7

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

416_461

465.0

Repeat

Note=WD 8

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

89_132

465.0

Repeat

Note=WD 1

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

136_174

395.0

Repeat

Note=WD 2

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

178_217

395.0

Repeat

Note=WD 3

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

222_263

395.0

Repeat

Note=WD 4

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

270_315

395.0

Repeat

Note=WD 5

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

320_367

395.0

Repeat

Note=WD 6

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

370_407

395.0

Repeat

Note=WD 7

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

416_461

395.0

Repeat

Note=WD 8

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

89_132

395.0

Repeat

Note=WD 1

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

136_174

446.0

Repeat

Note=WD 2

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

178_217

446.0

Repeat

Note=WD 3

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

222_263

446.0

Repeat

Note=WD 4

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

270_315

446.0

Repeat

Note=WD 5

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

320_367

446.0

Repeat

Note=WD 6

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

370_407

446.0

Repeat

Note=WD 7

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

416_461

446.0

Repeat

Note=WD 8

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

89_132

446.0

Repeat

Note=WD 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

QRICH1

chr3:49114142

chr3:48415038

ENST00000357496

85_462

103

777.0

Compositional bias

Note=Gln-rich

Hgene

QRICH1

chr3:49114142

chr3:48415038

ENST00000395443

85_462

103

777.0

Compositional bias

Note=Gln-rich

Hgene

QRICH1

chr3:49114142

chr3:48415038

ENST00000424300

85_462

103

777.0

Compositional bias

Note=Gln-rich

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000296438

1_45

465.0

Domain

F-box

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000415155

1_45

395.0

Domain

F-box

Tgene

FBXW12

chr3:49114142

chr3:48415038

ENST00000445170

1_45

446.0

Domain

F-box

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Fusion Gene Sequence for QRICH1-FBXW12

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>71006_71006_1_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000357496_FBXW12_chr3_48415038_ENST00000296438_length(transcript)=1874nt_BP=541nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAA
GAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTT
ATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATG
TGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCA
CTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCA
TGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAG
ATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACA
GTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAAT
TATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCA
CCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGT
GCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGC
TGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACG
TGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCT
GCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGA

>71006_71006_1_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000357496_FBXW12_chr3_48415038_ENST00000296438_length(amino acids)=458AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>71006_71006_2_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000357496_FBXW12_chr3_48415038_ENST00000415155_length(transcript)=1626nt_BP=541nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAA
GAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTT
ATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATG
TGCAAGAGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATG
GTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAG
AGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGG
TGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAG
GCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGAT
ATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCA
TCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATC
CATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAA
GCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGAC

>71006_71006_2_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000357496_FBXW12_chr3_48415038_ENST00000415155_length(amino acids)=388AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTL
PQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIW
MGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISS

--------------------------------------------------------------
>71006_71006_3_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000357496_FBXW12_chr3_48415038_ENST00000445170_length(transcript)=1836nt_BP=541nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAA
GAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTT
ATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATG
TGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCA
CTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCA
TGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAG
ATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACA
GTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAAT
TATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCA
CCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGT
GCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGC
TGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACG
TGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCT
GCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGA

>71006_71006_3_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000357496_FBXW12_chr3_48415038_ENST00000445170_length(amino acids)=458AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>71006_71006_4_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000395443_FBXW12_chr3_48415038_ENST00000296438_length(transcript)=2115nt_BP=782nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGC
AGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCA
CAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGAT
GAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGC
CCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTG
TGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCA
TTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATAT
GGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACA
GAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAG
GTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGA
GGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGA
TATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCC
ATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCAT
CCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCA
AGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGA

>71006_71006_4_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000395443_FBXW12_chr3_48415038_ENST00000296438_length(amino acids)=458AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>71006_71006_5_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000395443_FBXW12_chr3_48415038_ENST00000415155_length(transcript)=1867nt_BP=782nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGC
AGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCA
CAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGAT
GAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGTTGGCGATGCTGCAGGTGAC
ATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGAC
AAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGT
GTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAA
AGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATC
GCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATAC
TTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTAT
GTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAA
AACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGT

>71006_71006_5_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000395443_FBXW12_chr3_48415038_ENST00000415155_length(amino acids)=388AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTL
PQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIW
MGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISS

--------------------------------------------------------------
>71006_71006_6_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000395443_FBXW12_chr3_48415038_ENST00000445170_length(transcript)=2077nt_BP=782nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGC
AGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCA
CAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGAT
GAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGC
CCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTG
TGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCA
TTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATAT
GGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACA
GAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAG
GTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGA
GGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGA
TATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCC
ATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCAT
CCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCA
AGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGA

>71006_71006_6_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000395443_FBXW12_chr3_48415038_ENST00000445170_length(amino acids)=458AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>71006_71006_7_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000424300_FBXW12_chr3_48415038_ENST00000296438_length(transcript)=2080nt_BP=747nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACAC
ATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAA
CATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCC
AAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAAC
CCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCT
CCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTA
CACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAA
ATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCC
TCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAG
CACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAG
TTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTT
ACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCT
CACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACAC
GTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTC
CAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGACCTTGCATCATCTTCTGCAATGTAGTAAAGAAATT

>71006_71006_7_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000424300_FBXW12_chr3_48415038_ENST00000296438_length(amino acids)=458AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>71006_71006_8_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000424300_FBXW12_chr3_48415038_ENST00000415155_length(transcript)=1832nt_BP=747nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACAC
ATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAA
CATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCC
AAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGT
TTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCG
TACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATG
TGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTT
TGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCC
TATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCA
ACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTA
CATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCAT
CTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATAC

>71006_71006_8_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000424300_FBXW12_chr3_48415038_ENST00000415155_length(amino acids)=388AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTL
PQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIW
MGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISS

--------------------------------------------------------------
>71006_71006_9_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000424300_FBXW12_chr3_48415038_ENST00000445170_length(transcript)=2042nt_BP=747nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACAC
ATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAA
CATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCC
AAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAAC
CCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCT
CCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTA
CACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAA
ATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCC
TCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAG
CACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAG
TTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTT
ACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCT
CACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACAC
GTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTC

>71006_71006_9_QRICH1-FBXW12_QRICH1_chr3_49114142_ENST00000424300_FBXW12_chr3_48415038_ENST00000445170_length(amino acids)=458AA_BP=36
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for QRICH1-FBXW12

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for QRICH1-FBXW12

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for QRICH1-FBXW12

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source