Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:QRICH1-USP4 (FusionGDB2 ID:71018)

Fusion Gene Summary for QRICH1-USP4

Fusion gene summary

Fusion gene information	Fusion gene name: QRICH1-USP4
	Fusion gene ID: 71018
		Hgene	Tgene
	Gene symbol	QRICH1	USP4
	Gene ID	54870	7375
	Gene name	glutamine rich 1	ubiquitin specific peptidase 4
	Synonyms	AB-DIP\|VERBRAS	UNP\|Unph
	Cytomap	3p21.31	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	glutamine-rich protein 1	ubiquitin carboxyl-terminal hydrolase 4deubiquitinating enzyme 4ubiquitin carboxyl-terminal esterase 4ubiquitin specific peptidase 4 (proto-oncogene)ubiquitin specific protease 4 (proto-oncogene)ubiquitin thioesterase 4ubiquitin thiolesterase 4ubiq
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H9J4
	Ensembl transtripts involved in fusion gene	ENST00000357496, ENST00000395443, ENST00000424300, ENST00000479449,	ENST00000488520, ENST00000415188, ENST00000416417, ENST00000265560, ENST00000351842,
Fusion gene scores	* DoF score	19 X 13 X 10=2470	9 X 10 X 5=450
	# samples	20	9
	** MAII score	log2(20/2470*10)=-3.62643913669732 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/450*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: QRICH1 [Title/Abstract] AND USP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	QRICH1(49094294)-USP4(49315884), # samples:1 QRICH1(49114142)-USP4(49343321), # samples:1
Anticipated loss of major functional domain due to fusion event.	QRICH1-USP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	USP4	GO:0016579	protein deubiquitination	16316627\|16339847\|16472766
Tgene	USP4	GO:0031647	regulation of protein stability	16472766
Tgene	USP4	GO:0034394	protein localization to cell surface	16339847

Fusion gene breakpoints across QRICH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A8NI	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
ChimerDB4	LIHC	TCGA-2Y-A9GZ-01A	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-

Top

Fusion Gene ORF analysis for QRICH1-USP4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000357496	ENST00000488520	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-5UTR	ENST00000395443	ENST00000488520	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-5UTR	ENST00000424300	ENST00000488520	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000357496	ENST00000415188	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000357496	ENST00000415188	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000357496	ENST00000416417	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000357496	ENST00000416417	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000357496	ENST00000488520	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000395443	ENST00000415188	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000395443	ENST00000415188	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000395443	ENST00000416417	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000395443	ENST00000416417	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000395443	ENST00000488520	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000424300	ENST00000415188	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000424300	ENST00000415188	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000424300	ENST00000416417	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5CDS-intron	ENST00000424300	ENST00000416417	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
5CDS-intron	ENST00000424300	ENST00000488520	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5UTR-3CDS	ENST00000479449	ENST00000265560	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5UTR-3CDS	ENST00000479449	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5UTR-intron	ENST00000479449	ENST00000415188	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5UTR-intron	ENST00000479449	ENST00000416417	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
5UTR-intron	ENST00000479449	ENST00000488520	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
Frame-shift	ENST00000357496	ENST00000265560	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
Frame-shift	ENST00000357496	ENST00000265560	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
Frame-shift	ENST00000357496	ENST00000351842	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
Frame-shift	ENST00000395443	ENST00000265560	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
Frame-shift	ENST00000395443	ENST00000265560	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
Frame-shift	ENST00000395443	ENST00000351842	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
Frame-shift	ENST00000424300	ENST00000265560	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
Frame-shift	ENST00000424300	ENST00000265560	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
Frame-shift	ENST00000424300	ENST00000351842	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
In-frame	ENST00000357496	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
In-frame	ENST00000395443	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
In-frame	ENST00000424300	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-
intron-3CDS	ENST00000479449	ENST00000265560	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
intron-3CDS	ENST00000479449	ENST00000351842	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
intron-5UTR	ENST00000479449	ENST00000488520	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
intron-intron	ENST00000479449	ENST00000415188	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-
intron-intron	ENST00000479449	ENST00000416417	QRICH1	chr3	49114142	-	USP4	chr3	49343321	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395443	QRICH1	chr3	49094294	-	ENST00000351842	USP4	chr3	49315884	-	2432	1811	473	1969	498
ENST00000357496	QRICH1	chr3	49094294	-	ENST00000351842	USP4	chr3	49315884	-	2191	1570	232	1728	498
ENST00000424300	QRICH1	chr3	49094294	-	ENST00000351842	USP4	chr3	49315884	-	2397	1776	438	1934	498

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395443	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-	0.018579334	0.9814207
ENST00000357496	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-	0.029823452	0.9701765
ENST00000424300	ENST00000351842	QRICH1	chr3	49094294	-	USP4	chr3	49315884	-	0.028681964	0.97131807

Top

Fusion Genomic Features for QRICH1-USP4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for QRICH1-USP4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:49094294/chr3:49315884)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	USP4 Q9H9J4
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

QRICH1

chr3:49094294

chr3:49315884

ENST00000357496

1_64

446

777.0

Domain

Note=CARD

Hgene

QRICH1

chr3:49094294

chr3:49315884

ENST00000395443

1_64

446

777.0

Domain

Note=CARD

Hgene

QRICH1

chr3:49094294

chr3:49315884

ENST00000424300

1_64

446

777.0

Domain

Note=CARD

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

11_122

314.0

Domain

DUSP

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

142_226

314.0

Domain

Ubiquitin-like 1

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

302_923

314.0

Domain

USP

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

483_571

314.0

Domain

Ubiquitin-like 2

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

133_141

314.0

Motif

Nuclear export signal

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

767_772

314.0

Motif

Nuclear localization signal

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

229_295

314.0

Region

Required for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000416417

485_775

314.0

Region

Interacts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

QRICH1

chr3:49094294

chr3:49315884

ENST00000357496

85_462

446

777.0

Compositional bias

Note=Gln-rich

Hgene

QRICH1

chr3:49094294

chr3:49315884

ENST00000395443

85_462

446

777.0

Compositional bias

Note=Gln-rich

Hgene

QRICH1

chr3:49094294

chr3:49315884

ENST00000424300

85_462

446

777.0

Compositional bias

Note=Gln-rich

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

11_122

911

964.0

Domain

DUSP

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

142_226

911

964.0

Domain

Ubiquitin-like 1

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

302_923

911

964.0

Domain

USP

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

483_571

911

964.0

Domain

Ubiquitin-like 2

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

11_122

864

917.0

Domain

DUSP

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

142_226

864

917.0

Domain

Ubiquitin-like 1

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

302_923

864

917.0

Domain

USP

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

483_571

864

917.0

Domain

Ubiquitin-like 2

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

133_141

911

964.0

Motif

Nuclear export signal

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

767_772

911

964.0

Motif

Nuclear localization signal

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

133_141

864

917.0

Motif

Nuclear export signal

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

767_772

864

917.0

Motif

Nuclear localization signal

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

229_295

911

964.0

Region

Required for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000265560

485_775

911

964.0

Region

Interacts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

229_295

864

917.0

Region

Required for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains

Tgene

USP4

chr3:49094294

chr3:49315884

ENST00000351842

485_775

864

917.0

Region

Interacts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation

Top

Fusion Gene Sequence for QRICH1-USP4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>71018_71018_1_QRICH1-USP4_QRICH1_chr3_49094294_ENST00000357496_USP4_chr3_49315884_ENST00000351842_length(transcript)=2191nt_BP=1570nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCCAGGTGCAGGTACAGCAGTCTCCGCAACAGGTCTCGGCTCAGCTCTCCCCACAACTCACCGTTCACCAGCCTACTGAGCAACCCAT
CCAGGTCCAGGTGCAGATCCAAGGCCAGGCACCACAGTCAGCAGCCCCCTCCATTCAGACCCCGTCTCTGCAGAGTCCCAGTCCCTCGCA
GCTGCAAGCAGCTCAGATCCAGGTGCAGCACGTGCAAGCAGCCCAGCAGATCCAGGCTGCAGAAATCCCGGAGGAGCACATCCCACATCA
GCAAATCCAGGCTCAGCTGGTGGCTGGCCAGTCTCTTGCTGGTGGTCAGCAGATCCAAATCCAGACCGTGGGTGCCCTTTCCCCACCACC
ATCCCAGCAGGGCTCACCCCGGGAAGGGGAGCGGCGGGTTGGCACGGCCAGTGTCCTCCAACCAGTGAAGAAGCGCAAAGTGGACATGCC
CATCACTGTGTCCTACGCCATCTCAGGGCAGCCGGTGGCCACCGTGCTGGCCATTCCACAGGGCCAGCAGCAGAGTTATGTGTCTTTGAG
GCCAGACTTACTGACAGTAGACAGTGCCCACCTGTACAGTGCCACTGGGACCATTACTAGCCCTACAGGAGAAACCTGGACCATCCCTGT
TTATTCTGCCCAGCCCCGGGGGGACCCTCAGCAGCAGAGCATTACCCACATTGCCATTCCCCAGGAAGCCTACAACGCAGTTCACGTCAG
TGGCTCACCCACAGCCCTGGCAGCTGTTAAGCTGGAGGATGACAAGGAGAAGATGGTGGGCACCACATCTGTAGTGAAAAACTCCCATGA
AGAGGTAGTGCAGACCCTTGCAAACTCTCTCTTTCCAGCACAGTTCATGAATGGCAACATCCACATTCCAGTGGCTGTGCAGGCTGTGGC
AGGCACGTACCAGAATACGGCTCAAACTGTCCATATATGGGACCCCCAACAGCAGCCGCAGCAGCAAACTCCCCAGGAACAGACACCACC
ACCACAGCAGCAGCAGCAGCAACTCCAAGTTACTTGTTCAACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTA
TAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTG
CAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGC
AGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCGTTT
ACCTAGAAGAAGCTATGTCAAGAGGCTGAATTATTTTTATTTTTAAACAGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAGG
GGGTGGGATGGGGGTACTCAATGGAGTATGTCTGATGGATCCCGAAGAATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGA
CCCACCCCACCTGCAGGGCTGCCCTGAGCGCCTGGATTTCTGGTTCTGATGCCAATACTAGTCACCCCAAGTAGTCTGCTCACAGTAACC

>71018_71018_1_QRICH1-USP4_QRICH1_chr3_49094294_ENST00000357496_USP4_chr3_49315884_ENST00000351842_length(amino acids)=498AA_BP=446
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ
EQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQI
QAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLA
IPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEK
MVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSTKAA

--------------------------------------------------------------
>71018_71018_2_QRICH1-USP4_QRICH1_chr3_49094294_ENST00000395443_USP4_chr3_49315884_ENST00000351842_length(transcript)=2432nt_BP=1811nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCCAGGTGCAGGTACAGCAGTCTCCGC
AACAGGTCTCGGCTCAGCTCTCCCCACAACTCACCGTTCACCAGCCTACTGAGCAACCCATCCAGGTCCAGGTGCAGATCCAAGGCCAGG
CACCACAGTCAGCAGCCCCCTCCATTCAGACCCCGTCTCTGCAGAGTCCCAGTCCCTCGCAGCTGCAAGCAGCTCAGATCCAGGTGCAGC
ACGTGCAAGCAGCCCAGCAGATCCAGGCTGCAGAAATCCCGGAGGAGCACATCCCACATCAGCAAATCCAGGCTCAGCTGGTGGCTGGCC
AGTCTCTTGCTGGTGGTCAGCAGATCCAAATCCAGACCGTGGGTGCCCTTTCCCCACCACCATCCCAGCAGGGCTCACCCCGGGAAGGGG
AGCGGCGGGTTGGCACGGCCAGTGTCCTCCAACCAGTGAAGAAGCGCAAAGTGGACATGCCCATCACTGTGTCCTACGCCATCTCAGGGC
AGCCGGTGGCCACCGTGCTGGCCATTCCACAGGGCCAGCAGCAGAGTTATGTGTCTTTGAGGCCAGACTTACTGACAGTAGACAGTGCCC
ACCTGTACAGTGCCACTGGGACCATTACTAGCCCTACAGGAGAAACCTGGACCATCCCTGTTTATTCTGCCCAGCCCCGGGGGGACCCTC
AGCAGCAGAGCATTACCCACATTGCCATTCCCCAGGAAGCCTACAACGCAGTTCACGTCAGTGGCTCACCCACAGCCCTGGCAGCTGTTA
AGCTGGAGGATGACAAGGAGAAGATGGTGGGCACCACATCTGTAGTGAAAAACTCCCATGAAGAGGTAGTGCAGACCCTTGCAAACTCTC
TCTTTCCAGCACAGTTCATGAATGGCAACATCCACATTCCAGTGGCTGTGCAGGCTGTGGCAGGCACGTACCAGAATACGGCTCAAACTG
TCCATATATGGGACCCCCAACAGCAGCCGCAGCAGCAAACTCCCCAGGAACAGACACCACCACCACAGCAGCAGCAGCAGCAACTCCAAG
TTACTTGTTCAACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTT
CCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTGACTCC
ACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAAACCAG
ACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCGTTTACCTAGAAGAAGCTATGTCAAGAGGCTGA
ATTATTTTTATTTTTAAACAGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAGGGGGTGGGATGGGGGTACTCAATGGAGTAT
GTCTGATGGATCCCGAAGAATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGACCCACCCCACCTGCAGGGCTGCCCTGAGC
GCCTGGATTTCTGGTTCTGATGCCAATACTAGTCACCCCAAGTAGTCTGCTCACAGTAACCCAAACCTCAAGTAAACTCCCCTTTCCCTC

>71018_71018_2_QRICH1-USP4_QRICH1_chr3_49094294_ENST00000395443_USP4_chr3_49315884_ENST00000351842_length(amino acids)=498AA_BP=446
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ
EQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQI
QAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLA
IPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEK
MVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSTKAA

--------------------------------------------------------------
>71018_71018_3_QRICH1-USP4_QRICH1_chr3_49094294_ENST00000424300_USP4_chr3_49315884_ENST00000351842_length(transcript)=2397nt_BP=1776nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCCAGGTGCAGGTACAGCAGTCTCCGCAACAGGTCTCGGCTCAGCTCTCCCCACAACTCACC
GTTCACCAGCCTACTGAGCAACCCATCCAGGTCCAGGTGCAGATCCAAGGCCAGGCACCACAGTCAGCAGCCCCCTCCATTCAGACCCCG
TCTCTGCAGAGTCCCAGTCCCTCGCAGCTGCAAGCAGCTCAGATCCAGGTGCAGCACGTGCAAGCAGCCCAGCAGATCCAGGCTGCAGAA
ATCCCGGAGGAGCACATCCCACATCAGCAAATCCAGGCTCAGCTGGTGGCTGGCCAGTCTCTTGCTGGTGGTCAGCAGATCCAAATCCAG
ACCGTGGGTGCCCTTTCCCCACCACCATCCCAGCAGGGCTCACCCCGGGAAGGGGAGCGGCGGGTTGGCACGGCCAGTGTCCTCCAACCA
GTGAAGAAGCGCAAAGTGGACATGCCCATCACTGTGTCCTACGCCATCTCAGGGCAGCCGGTGGCCACCGTGCTGGCCATTCCACAGGGC
CAGCAGCAGAGTTATGTGTCTTTGAGGCCAGACTTACTGACAGTAGACAGTGCCCACCTGTACAGTGCCACTGGGACCATTACTAGCCCT
ACAGGAGAAACCTGGACCATCCCTGTTTATTCTGCCCAGCCCCGGGGGGACCCTCAGCAGCAGAGCATTACCCACATTGCCATTCCCCAG
GAAGCCTACAACGCAGTTCACGTCAGTGGCTCACCCACAGCCCTGGCAGCTGTTAAGCTGGAGGATGACAAGGAGAAGATGGTGGGCACC
ACATCTGTAGTGAAAAACTCCCATGAAGAGGTAGTGCAGACCCTTGCAAACTCTCTCTTTCCAGCACAGTTCATGAATGGCAACATCCAC
ATTCCAGTGGCTGTGCAGGCTGTGGCAGGCACGTACCAGAATACGGCTCAAACTGTCCATATATGGGACCCCCAACAGCAGCCGCAGCAG
CAAACTCCCCAGGAACAGACACCACCACCACAGCAGCAGCAGCAGCAACTCCAAGTTACTTGTTCAACTAAAGCAGCTTATGTGCTATTT
TACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAG
CAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCC
CCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAA
ACAAAAAAAAAAAAAGAAGACCGTTTACCTAGAAGAAGCTATGTCAAGAGGCTGAATTATTTTTATTTTTAAACAGGTGGTGAGAAATTT
CTGTGAAACCTGTGAAGCTGAAAAGGGGGTGGGATGGGGGTACTCAATGGAGTATGTCTGATGGATCCCGAAGAATGGAGAGGAACACAG
GCGCTGAGTATGGAGCAGCCTGGAGACCCACCCCACCTGCAGGGCTGCCCTGAGCGCCTGGATTTCTGGTTCTGATGCCAATACTAGTCA

>71018_71018_3_QRICH1-USP4_QRICH1_chr3_49094294_ENST00000424300_USP4_chr3_49315884_ENST00000351842_length(amino acids)=498AA_BP=446
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ
EQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQI
QAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLA
IPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEK
MVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSTKAA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for QRICH1-USP4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for QRICH1-USP4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for QRICH1-USP4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source