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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:QTRT1-IRF2BP2 (FusionGDB2 ID:71046)

Fusion Gene Summary for QTRT1-IRF2BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: QTRT1-IRF2BP2
Fusion gene ID: 71046
HgeneTgene
Gene symbol

QTRT1

IRF2BP2

Gene ID

81890

359948

Gene namequeuine tRNA-ribosyltransferase catalytic subunit 1interferon regulatory factor 2 binding protein 2
SynonymsFP3235|TGT|TGUTCVID14
Cytomap

19p13.2

1q42.3

Type of geneprotein-codingprotein-coding
Descriptionqueuine tRNA-ribosyltransferase catalytic subunit 1TGT, 43-KD subunitTGT, catalytic subunitguanine insertion enzymequeuine tRNA-ribosyltransferase 1tRNA-guanine transglycosylaseinterferon regulatory factor 2-binding protein 2IRF-2-binding protein 2
Modification date2020032020200313
UniProtAcc.

Q7Z5L9

Ensembl transtripts involved in fusion geneENST00000250237, ENST00000585885, 
ENST00000491430, ENST00000366609, 
ENST00000366610, 
Fusion gene scores* DoF score2 X 3 X 2=129 X 6 X 4=216
# samples 39
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: QTRT1 [Title/Abstract] AND IRF2BP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointQTRT1(10823892)-IRF2BP2(234743504), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneQTRT1

GO:0101030

tRNA-guanine transglycosylation

20354154

TgeneIRF2BP2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799427

TgeneIRF2BP2

GO:0002327

immature B cell differentiation

27016798


check buttonFusion gene breakpoints across QTRT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IRF2BP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI919001QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+


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Fusion Gene ORF analysis for QTRT1-IRF2BP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000250237ENST00000491430QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+
In-frameENST00000250237ENST00000366609QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+
In-frameENST00000250237ENST00000366610QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+
intron-3CDSENST00000585885ENST00000366609QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+
intron-3CDSENST00000585885ENST00000366610QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+
intron-5UTRENST00000585885ENST00000491430QTRT1chr19

10823892

-IRF2BP2chr1

234743504

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000250237QTRT1chr1910823892-ENST00000366610IRF2BP2chr1234743504+47081218101122370
ENST00000250237QTRT1chr1910823892-ENST00000366609IRF2BP2chr1234743504+47081218101122370

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000250237ENST00000366610QTRT1chr1910823892-IRF2BP2chr1234743504+0.0016147220.9983853
ENST00000250237ENST00000366609QTRT1chr1910823892-IRF2BP2chr1234743504+0.0016147220.9983853

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Fusion Genomic Features for QTRT1-IRF2BP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for QTRT1-IRF2BP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10823892/chr1:234743504)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IRF2BP2

Q7Z5L9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036660902104_2000588.0Compositional biasNote=Pro-rich
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036661002104_2000572.0Compositional biasNote=Pro-rich
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036660902354_3610588.0MotifNuclear localization signal
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036661002354_3610572.0MotifNuclear localization signal
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036660902506_5500588.0RegionNote=Cys-rich
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036661002506_5500572.0RegionNote=Cys-rich
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036660902506_5530588.0Zinc fingerNote=RING-type%3B degenerate
TgeneIRF2BP2chr19:10823892chr1:234743504ENST0000036661002506_5530572.0Zinc fingerNote=RING-type%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneQTRT1chr19:10823892chr1:234743504ENST00000250237-110105_1090404.0RegionSubstrate binding
HgeneQTRT1chr19:10823892chr1:234743504ENST00000250237-110260_2660404.0RegionRNA binding
HgeneQTRT1chr19:10823892chr1:234743504ENST00000250237-110284_2880404.0RegionRNA binding%3B important for wobble base 34 recognition


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Fusion Gene Sequence for QTRT1-IRF2BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71046_71046_1_QTRT1-IRF2BP2_QTRT1_chr19_10823892_ENST00000250237_IRF2BP2_chr1_234743504_ENST00000366609_length(transcript)=4708nt_BP=1218nt
GACAGTCAAGATGGCGGGAGCAGCTACCCAGGCTTCCCTGGAGTCGGCCCCACGGATCATGCGGCTGGTGGCCGAATGCAGCCGCTCCAG
GGCCCGGGCAGGCGAGCTGTGGCTGCCGCATGGGACAGTGGCCACTCCTGTGTTCATGCCAGTGGGCACGCAGGCCACCATGAAGGGCAT
CACGACCGAACAGCTGGACGCTCTGGGTTGCCGCATCTGCCTGGGCAATACCTACCATCTGGGTCTAAGGCCGGGACCCGAGCTGATCCA
GAAAGCCAACGGTCTCCACGGCTTCATGAATTGGCCTCATAATCTGCTAACGGACAGCGGCGGTTTCCAGATGGTGTCGCTGGTGTCTCT
GTCCGAGGTGACGGAGGAGGGCGTCCGCTTCCGCTCCCCCTACGACGGCAATGAGACCCTGCTGAGCCCGGAGAAATCCGTGCAGATCCA
GAATGCGCTGGGCTCGGACATCATCATGCAGCTGGACGACGTGGTTAGCAGTACTGTGACTGGGCCACGTGTGGAGGAGGCCATGTACAG
GTCAATCCGCTGGCTGGACCGGTGCATTGCAGCCCATCAGCGGCCGGACAAGCAGAACCTCTTCGCCATTATCCAGGGTGGGCTGGACGC
AGATCTCCGGGCCACCTGCCTTGAAGAGATGACCAAGCGAGACGTGCCTGGCTTCGCCATCGGGGGCCTGAGCGGGGGTGAGAGCAAGTC
GCAGTTCTGGCGGATGGTGGCGCTGAGCACCTCTCGGCTGCCGAAGGACAAGCCCCGATATCTGATGGGGGTTGGCTATGCCACTGATCT
GGTAGTCTGCGTGGCTCTTGGATGTGACATGTTCGACTGCGTCTTCCCCACACGGACAGCGCGCTTTGGCTCTGCCCTGGTGCCCACTGG
GAACCTGCAGTTGAGGAAGAAGGTGTTTGAGAAGGACTTCGGCCCCATAGACCCGGAGTGCACCTGCCCCACGTGCCAAAAGCACAGCCG
CGCCTTCCTGCACGCACTGCTGCACAGTGACAACACGGCCGCGCTGCACCACCTCACGGTCCACAACATCGCCTACCAGTGTCCCACCTG
GGCCACTGACGCTCTGGCCTCTGTGGGAATCACACTGGGCTGACCTGGCATTGGGAGAGGGAGGGAGGAAGGAAGGGAGGGAGGGGCTGG
AAGATACTGAAGGATTCCTTTTTGAAAGGTTTTTTTTATTGTAACTTACACATCCACAGAGGGGCTCAAGATCCCCATGACTCCTACATC
CTCTTTTGTGTCTCCGCCACCACCCACTGCCTCACCTCATTCCAACCGGACCACACCGCCTGAAGCGGCCCAGAATGGCCAGTCCCCCAT
GGCAGCCCTGATCTTAGTAGCAGACAATGCAGGGGGCAGTCATGCCTCAAAAGATGCCAACCAGGTTCACTCCACTACCAGGAGGAATAG
CAACAGTCCGCCCTCTCCGTCCTCTATGAACCAAAGAAGGCTGGGCCCCAGAGAGGTGGGGGGCCAGGGAGCAGGCAACACAGGAGGACT
GGAGCCAGTGCACCCTGCCAGCCTCCCGGACTCCTCTCTGGCAACCAGTGCCCCGCTGTGCTGCACCCTCTGCCACGAGCGGCTGGAGGA
CACCCATTTTGTGCAGTGCCCGTCCGTCCCTTCGCACAAGTTCTGCTTCCCTTGCTCCAGACAAAGCATCAAACAGCAGGGAGCTAGTGG
AGAGGTCTATTGTCCCAGTGGGGAAAAATGCCCTCTTGTGGGCTCCAATGTCCCCTGGGCCTTTATGCAAGGGGAAATTGCAACCATCCT
TGCTGGAGATGTGAAAGTGAAAAAAGAGAGAGACTCGTGACTTTTCCGGTTTCAGAAAAACCCAATGATTACCCTTAATTAAAACTGCTT
GAATTGTATATATATCTCCATATATATATATATCCAAGACAAGGGAAATGTAGACTTCATAAACATGGCTGTATAATTTTGATTTTTTTT
GAATACATTGTGTTTCTATATTTTTTTTGACGACAAAAGGTATGTACTTATAAAGACATTTTTTTCTTTTGTTAACGTTATTAGCATATC
TTTGTGCTTTATTATCCTGGTGACAGTTACCGTTCTATGTAGGCTGTGACTTGCGCTGCTTTTTTAGAGCACTTGGCAAATCAGAAATGC
TTCTAGCTGTATTTGTATGCACTTATTTTAAAAAGAAAAAAAAAGCCAAATACATTTTCTGACATTGTAAGATTGCCTTACTGTCTGTCA
TTCCTTATTGCTGGCCCCTTTCTCAGGCCGGAGGCCAAGTGGTGGAGAAGGAAAGGAAATGATCGAACGGGCATGTTGTCAAGTGGGCAT
GCCACTGGGAAATACCACCAGTTTACCCTGAAACATTGTCCTCAGAGGAGTAGGAAAGTGGATTTTGAATCTCTATTTTGCTCAAAAGTT
CAGTTCCTGAGATACTGATGACTGAGAGTGCTGCTGGGAAATTTTCAGGATTGTGTGGTCTTTTGGGGTTTTTTGTTTTTTTTTTTTTAA
GACAAAGTTGACCGCTGTTCACTGTCCACGTGATCAGTTGTAAGATTACAATGCTGCATGCTAGTTGGTTACATAAGATACAATTCCAGT
GATGGAAGGCGGTTATAATGGATGGTGGTGTGTACAAGATGGCACTGCCATCTTTGAGCAGAGCCCAGCTCTGCAGCGCCACTTCATCTT
TTTAAACACCCTAGAGGTCTGTTTGTTGTTGCTGTTGTCCTTTATTTTGAAAGAGTTGCAAGAGAAGTTACAGTCCAGGTGAACTTGGAG
ATTGTGGGATTGGTTTTGTTTCTGTTTTGTTTTGTTTATCATTTACCTGTAGTGCTATTGCTGTTGATACTATCACCTATACCCTGTTTC
TAGTGAGTGCTGAATACAGTATGGTACAATGACAGTAACAGCCGCGTGGTGCTGCCAGGACTGCCCTTGGGCATATCAGTGACAGCCCAA
ATGTGGGTGGAGGAAACCTGTAATTTCCTTCTTAACATGTGTTTGAAATACCAAGTGAATAATACTGTTCTGGAAAAAAATGATAAACTA
GTGGAAATTAAAGAAATTAAGGGTTTTATATAATAGACAGGCCCCACCTCTCAAAATATTTTTAGAAGTCTTTTTGTAAACTAATTTCTT
TTGATCACTATTTTGCATCAGTAAAATGATTTTTTTAAAACCAATAAATCATCAATTATTAGAAATAGTTGTCTCACAGTGATACTGGTT
TTTCTTTTGTGCTGTTATGATTTAACATTGACAGGAACACTATTTTAAATCCTTACGTTCAGGTGTTTGTAACTTGGCCTTATAATTAGG
CTGAATTATGGCTTCAAGGTCTACAATTTATGTGTATGGTTCACAGCCTAGCTTCTATTTACATTTGAAAATACAGATTTTTACCAACTT
TGGATTCTTTTTTAGTTATATGTTTGTCTTTCCTTTTTAAATTGTTCAAAACTATTTTTTAATGGTCAAGTTACTAACACTTGAAAATCA
GATACTGCACCAAATACAGTGTTTTTCCGTAGTGTTTTTAATGAGTGCACCTATTACTACTGTGCGAGAATTCATGTTTTACCAGTCATT
GTTATATTACAAACAGACTTGCATGATTAACCAGTTGTTACACTTACTTTTTCAAGTTGGAGTATATATGACTCAGTGCAGACTGGTCTC
TCTTATGTGAATGCACACATGCAGAAATGCAGAGTCAATTTTACATGCCCATAAAGACATTTGTAAAGAATTCAGCTCTTATGGTCTGTT
GTATAAATGTGTATCTAGGCACTTTGGAATTTGACCTCACAGATGTTACAACTTGATCAGTCGTTTGACCTAATTTGTGGTAGCTATCTG
TATGTTTTGCAATCTTAATACAGACATGCTTTCCAAAAAGATTAATACAGAACCATCCTGCCGTTTTGGATAAGTCTATCCAGCTGTGGA
AAGGGCAACCTGTGGTTTCTCTGTACTGGTGTTTAATGGGGGAAGAATATGAACAGCTTTAAAGAGCTGTGTATTGTGGTTACTACTATT
AAAAAATAAGATCTGCACGAGTCTGACTGGCCTTTGGGTGGCCTTTGTGGACGGCTCGTAGCTGGAAAGTGTTGATCTGGGTTTTCTGGC
ATTCTTTTAAGTTAAAAAGTTAACATCGGGACATGGGTTTGATCTTTTGTTGTACCTGATGACAGTGCAGAGATTCTCCACAGCTGGATA
AAAATGTCACAAAGCTACTTACTGTACATGGGCAGTATCAGATTTCAAATCCTAATATTTCAGCTGTGCTTTTAATACTCAAAATATTAG
GGGATGGGGTGTTGAAGCTTTCCCTTTTTTGCTTTTAACAATTTATAGAATTTAACAGATGTACTGTCTTTCATGTGGCCTCACATTTAA
AGTTATGAGAACATACACATGGTTTACAACTTTTACTATATACCTTTCCTTGGCCACCAAGTATTTTAAAAGTGTGCCACCTTTTAACCT
TTACTTTTTTTAAGTTGAAGGTGATACTTTTTCTATATATGATGAAACTCATGTCAACTGAAGTGAGTGTAATCTCAGATACCAACATTA
TTATATTTTAAAATCACGCTATGGAAATATCACCTGAATTCTGTCATTTGTCAGATTTACAGTACCTTTTTTTCTTTAACTTTTAGCATT

>71046_71046_1_QTRT1-IRF2BP2_QTRT1_chr19_10823892_ENST00000250237_IRF2BP2_chr1_234743504_ENST00000366609_length(amino acids)=370AA_BP=
MAGAATQASLESAPRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYHLGLRPGPELIQKAN
GLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIR
WLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGYATDLVVC
VALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQCPTWATD

--------------------------------------------------------------
>71046_71046_2_QTRT1-IRF2BP2_QTRT1_chr19_10823892_ENST00000250237_IRF2BP2_chr1_234743504_ENST00000366610_length(transcript)=4708nt_BP=1218nt
GACAGTCAAGATGGCGGGAGCAGCTACCCAGGCTTCCCTGGAGTCGGCCCCACGGATCATGCGGCTGGTGGCCGAATGCAGCCGCTCCAG
GGCCCGGGCAGGCGAGCTGTGGCTGCCGCATGGGACAGTGGCCACTCCTGTGTTCATGCCAGTGGGCACGCAGGCCACCATGAAGGGCAT
CACGACCGAACAGCTGGACGCTCTGGGTTGCCGCATCTGCCTGGGCAATACCTACCATCTGGGTCTAAGGCCGGGACCCGAGCTGATCCA
GAAAGCCAACGGTCTCCACGGCTTCATGAATTGGCCTCATAATCTGCTAACGGACAGCGGCGGTTTCCAGATGGTGTCGCTGGTGTCTCT
GTCCGAGGTGACGGAGGAGGGCGTCCGCTTCCGCTCCCCCTACGACGGCAATGAGACCCTGCTGAGCCCGGAGAAATCCGTGCAGATCCA
GAATGCGCTGGGCTCGGACATCATCATGCAGCTGGACGACGTGGTTAGCAGTACTGTGACTGGGCCACGTGTGGAGGAGGCCATGTACAG
GTCAATCCGCTGGCTGGACCGGTGCATTGCAGCCCATCAGCGGCCGGACAAGCAGAACCTCTTCGCCATTATCCAGGGTGGGCTGGACGC
AGATCTCCGGGCCACCTGCCTTGAAGAGATGACCAAGCGAGACGTGCCTGGCTTCGCCATCGGGGGCCTGAGCGGGGGTGAGAGCAAGTC
GCAGTTCTGGCGGATGGTGGCGCTGAGCACCTCTCGGCTGCCGAAGGACAAGCCCCGATATCTGATGGGGGTTGGCTATGCCACTGATCT
GGTAGTCTGCGTGGCTCTTGGATGTGACATGTTCGACTGCGTCTTCCCCACACGGACAGCGCGCTTTGGCTCTGCCCTGGTGCCCACTGG
GAACCTGCAGTTGAGGAAGAAGGTGTTTGAGAAGGACTTCGGCCCCATAGACCCGGAGTGCACCTGCCCCACGTGCCAAAAGCACAGCCG
CGCCTTCCTGCACGCACTGCTGCACAGTGACAACACGGCCGCGCTGCACCACCTCACGGTCCACAACATCGCCTACCAGTGTCCCACCTG
GGCCACTGACGCTCTGGCCTCTGTGGGAATCACACTGGGCTGACCTGGCATTGGGAGAGGGAGGGAGGAAGGAAGGGAGGGAGGGGCTGG
AAGATACTGAAGGATTCCTTTTTGAAAGGTTTTTTTTATTGTAACTTACACATCCACAGAGGGGCTCAAGATCCCCATGACTCCTACATC
CTCTTTTGTGTCTCCGCCACCACCCACTGCCTCACCTCATTCCAACCGGACCACACCGCCTGAAGCGGCCCAGAATGGCCAGTCCCCCAT
GGCAGCCCTGATCTTAGTAGCAGACAATGCAGGGGGCAGTCATGCCTCAAAAGATGCCAACCAGGTTCACTCCACTACCAGGAGGAATAG
CAACAGTCCGCCCTCTCCGTCCTCTATGAACCAAAGAAGGCTGGGCCCCAGAGAGGTGGGGGGCCAGGGAGCAGGCAACACAGGAGGACT
GGAGCCAGTGCACCCTGCCAGCCTCCCGGACTCCTCTCTGGCAACCAGTGCCCCGCTGTGCTGCACCCTCTGCCACGAGCGGCTGGAGGA
CACCCATTTTGTGCAGTGCCCGTCCGTCCCTTCGCACAAGTTCTGCTTCCCTTGCTCCAGACAAAGCATCAAACAGCAGGGAGCTAGTGG
AGAGGTCTATTGTCCCAGTGGGGAAAAATGCCCTCTTGTGGGCTCCAATGTCCCCTGGGCCTTTATGCAAGGGGAAATTGCAACCATCCT
TGCTGGAGATGTGAAAGTGAAAAAAGAGAGAGACTCGTGACTTTTCCGGTTTCAGAAAAACCCAATGATTACCCTTAATTAAAACTGCTT
GAATTGTATATATATCTCCATATATATATATATCCAAGACAAGGGAAATGTAGACTTCATAAACATGGCTGTATAATTTTGATTTTTTTT
GAATACATTGTGTTTCTATATTTTTTTTGACGACAAAAGGTATGTACTTATAAAGACATTTTTTTCTTTTGTTAACGTTATTAGCATATC
TTTGTGCTTTATTATCCTGGTGACAGTTACCGTTCTATGTAGGCTGTGACTTGCGCTGCTTTTTTAGAGCACTTGGCAAATCAGAAATGC
TTCTAGCTGTATTTGTATGCACTTATTTTAAAAAGAAAAAAAAAGCCAAATACATTTTCTGACATTGTAAGATTGCCTTACTGTCTGTCA
TTCCTTATTGCTGGCCCCTTTCTCAGGCCGGAGGCCAAGTGGTGGAGAAGGAAAGGAAATGATCGAACGGGCATGTTGTCAAGTGGGCAT
GCCACTGGGAAATACCACCAGTTTACCCTGAAACATTGTCCTCAGAGGAGTAGGAAAGTGGATTTTGAATCTCTATTTTGCTCAAAAGTT
CAGTTCCTGAGATACTGATGACTGAGAGTGCTGCTGGGAAATTTTCAGGATTGTGTGGTCTTTTGGGGTTTTTTGTTTTTTTTTTTTTAA
GACAAAGTTGACCGCTGTTCACTGTCCACGTGATCAGTTGTAAGATTACAATGCTGCATGCTAGTTGGTTACATAAGATACAATTCCAGT
GATGGAAGGCGGTTATAATGGATGGTGGTGTGTACAAGATGGCACTGCCATCTTTGAGCAGAGCCCAGCTCTGCAGCGCCACTTCATCTT
TTTAAACACCCTAGAGGTCTGTTTGTTGTTGCTGTTGTCCTTTATTTTGAAAGAGTTGCAAGAGAAGTTACAGTCCAGGTGAACTTGGAG
ATTGTGGGATTGGTTTTGTTTCTGTTTTGTTTTGTTTATCATTTACCTGTAGTGCTATTGCTGTTGATACTATCACCTATACCCTGTTTC
TAGTGAGTGCTGAATACAGTATGGTACAATGACAGTAACAGCCGCGTGGTGCTGCCAGGACTGCCCTTGGGCATATCAGTGACAGCCCAA
ATGTGGGTGGAGGAAACCTGTAATTTCCTTCTTAACATGTGTTTGAAATACCAAGTGAATAATACTGTTCTGGAAAAAAATGATAAACTA
GTGGAAATTAAAGAAATTAAGGGTTTTATATAATAGACAGGCCCCACCTCTCAAAATATTTTTAGAAGTCTTTTTGTAAACTAATTTCTT
TTGATCACTATTTTGCATCAGTAAAATGATTTTTTTAAAACCAATAAATCATCAATTATTAGAAATAGTTGTCTCACAGTGATACTGGTT
TTTCTTTTGTGCTGTTATGATTTAACATTGACAGGAACACTATTTTAAATCCTTACGTTCAGGTGTTTGTAACTTGGCCTTATAATTAGG
CTGAATTATGGCTTCAAGGTCTACAATTTATGTGTATGGTTCACAGCCTAGCTTCTATTTACATTTGAAAATACAGATTTTTACCAACTT
TGGATTCTTTTTTAGTTATATGTTTGTCTTTCCTTTTTAAATTGTTCAAAACTATTTTTTAATGGTCAAGTTACTAACACTTGAAAATCA
GATACTGCACCAAATACAGTGTTTTTCCGTAGTGTTTTTAATGAGTGCACCTATTACTACTGTGCGAGAATTCATGTTTTACCAGTCATT
GTTATATTACAAACAGACTTGCATGATTAACCAGTTGTTACACTTACTTTTTCAAGTTGGAGTATATATGACTCAGTGCAGACTGGTCTC
TCTTATGTGAATGCACACATGCAGAAATGCAGAGTCAATTTTACATGCCCATAAAGACATTTGTAAAGAATTCAGCTCTTATGGTCTGTT
GTATAAATGTGTATCTAGGCACTTTGGAATTTGACCTCACAGATGTTACAACTTGATCAGTCGTTTGACCTAATTTGTGGTAGCTATCTG
TATGTTTTGCAATCTTAATACAGACATGCTTTCCAAAAAGATTAATACAGAACCATCCTGCCGTTTTGGATAAGTCTATCCAGCTGTGGA
AAGGGCAACCTGTGGTTTCTCTGTACTGGTGTTTAATGGGGGAAGAATATGAACAGCTTTAAAGAGCTGTGTATTGTGGTTACTACTATT
AAAAAATAAGATCTGCACGAGTCTGACTGGCCTTTGGGTGGCCTTTGTGGACGGCTCGTAGCTGGAAAGTGTTGATCTGGGTTTTCTGGC
ATTCTTTTAAGTTAAAAAGTTAACATCGGGACATGGGTTTGATCTTTTGTTGTACCTGATGACAGTGCAGAGATTCTCCACAGCTGGATA
AAAATGTCACAAAGCTACTTACTGTACATGGGCAGTATCAGATTTCAAATCCTAATATTTCAGCTGTGCTTTTAATACTCAAAATATTAG
GGGATGGGGTGTTGAAGCTTTCCCTTTTTTGCTTTTAACAATTTATAGAATTTAACAGATGTACTGTCTTTCATGTGGCCTCACATTTAA
AGTTATGAGAACATACACATGGTTTACAACTTTTACTATATACCTTTCCTTGGCCACCAAGTATTTTAAAAGTGTGCCACCTTTTAACCT
TTACTTTTTTTAAGTTGAAGGTGATACTTTTTCTATATATGATGAAACTCATGTCAACTGAAGTGAGTGTAATCTCAGATACCAACATTA
TTATATTTTAAAATCACGCTATGGAAATATCACCTGAATTCTGTCATTTGTCAGATTTACAGTACCTTTTTTTCTTTAACTTTTAGCATT

>71046_71046_2_QTRT1-IRF2BP2_QTRT1_chr19_10823892_ENST00000250237_IRF2BP2_chr1_234743504_ENST00000366610_length(amino acids)=370AA_BP=
MAGAATQASLESAPRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYHLGLRPGPELIQKAN
GLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIR
WLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGYATDLVVC
VALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQCPTWATD

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Fusion Gene PPI Analysis for QTRT1-IRF2BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for QTRT1-IRF2BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for QTRT1-IRF2BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource