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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:R3HCC1-GRIK5 (FusionGDB2 ID:71051) |
Fusion Gene Summary for R3HCC1-GRIK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: R3HCC1-GRIK5 | Fusion gene ID: 71051 | Hgene | Tgene | Gene symbol | R3HCC1 | GRIK5 | Gene ID | 203069 | 2901 |
| Gene name | R3H domain and coiled-coil containing 1 | glutamate ionotropic receptor kainate type subunit 5 | |
| Synonyms | - | EAA2|GRIK2|GluK5|KA2 | |
| Cytomap | 8p21.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | R3H and coiled-coil domain-containing protein 1 | glutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q16478 | |
| Ensembl transtripts involved in fusion gene | ENST00000522012, ENST00000265806, ENST00000411463, ENST00000518454, | ENST00000262895, ENST00000301218, ENST00000593562, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 6 X 6 X 5=180 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: R3HCC1 [Title/Abstract] AND GRIK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | R3HCC1(23147982)-GRIK5(42526506), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across R3HCC1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GRIK5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-L5-A891-01A | R3HCC1 | chr8 | 23147982 | - | GRIK5 | chr19 | 42526506 | - |
| ChimerDB4 | ESCA | TCGA-L5-A891-01A | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| ChimerDB4 | ESCA | TCGA-L5-A891 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
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Fusion Gene ORF analysis for R3HCC1-GRIK5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000522012 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| 3UTR-3CDS | ENST00000522012 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| 3UTR-3CDS | ENST00000522012 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000265806 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000265806 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000265806 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000411463 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000411463 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000411463 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000518454 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000518454 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| In-frame | ENST00000518454 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000518454 | R3HCC1 | chr8 | 23147982 | + | ENST00000262895 | GRIK5 | chr19 | 42526506 | - | 3014 | 994 | 208 | 2463 | 751 |
| ENST00000518454 | R3HCC1 | chr8 | 23147982 | + | ENST00000593562 | GRIK5 | chr19 | 42526506 | - | 2521 | 994 | 208 | 2463 | 751 |
| ENST00000518454 | R3HCC1 | chr8 | 23147982 | + | ENST00000301218 | GRIK5 | chr19 | 42526506 | - | 2796 | 994 | 208 | 2466 | 752 |
| ENST00000265806 | R3HCC1 | chr8 | 23147982 | + | ENST00000262895 | GRIK5 | chr19 | 42526506 | - | 3140 | 1120 | 208 | 2589 | 793 |
| ENST00000265806 | R3HCC1 | chr8 | 23147982 | + | ENST00000593562 | GRIK5 | chr19 | 42526506 | - | 2647 | 1120 | 208 | 2589 | 793 |
| ENST00000265806 | R3HCC1 | chr8 | 23147982 | + | ENST00000301218 | GRIK5 | chr19 | 42526506 | - | 2922 | 1120 | 208 | 2592 | 794 |
| ENST00000411463 | R3HCC1 | chr8 | 23147982 | + | ENST00000262895 | GRIK5 | chr19 | 42526506 | - | 2992 | 972 | 0 | 2441 | 813 |
| ENST00000411463 | R3HCC1 | chr8 | 23147982 | + | ENST00000593562 | GRIK5 | chr19 | 42526506 | - | 2499 | 972 | 0 | 2441 | 813 |
| ENST00000411463 | R3HCC1 | chr8 | 23147982 | + | ENST00000301218 | GRIK5 | chr19 | 42526506 | - | 2774 | 972 | 0 | 2444 | 814 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000518454 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.015628317 | 0.9843717 |
| ENST00000518454 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.020407813 | 0.97959214 |
| ENST00000518454 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.012634994 | 0.98736507 |
| ENST00000265806 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.014312563 | 0.98568743 |
| ENST00000265806 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.018311938 | 0.9816881 |
| ENST00000265806 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.012130932 | 0.9878691 |
| ENST00000411463 | ENST00000262895 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.009861569 | 0.9901384 |
| ENST00000411463 | ENST00000593562 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.013330504 | 0.98666954 |
| ENST00000411463 | ENST00000301218 | R3HCC1 | chr8 | 23147982 | + | GRIK5 | chr19 | 42526506 | - | 0.006334953 | 0.9936651 |
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Fusion Genomic Features for R3HCC1-GRIK5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for R3HCC1-GRIK5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:23147982/chr19:42526506) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GRIK5 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | R3HCC1 | chr8:23147982 | chr19:42526506 | ENST00000411463 | + | 5 | 9 | 242_300 | 324 | 481.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | R3HCC1 | chr8:23147982 | chr19:42526506 | ENST00000265806 | + | 4 | 8 | 16_81 | 97 | 254.0 | Domain | R3H |
| Hgene | R3HCC1 | chr8:23147982 | chr19:42526506 | ENST00000411463 | + | 5 | 9 | 16_81 | 324 | 481.0 | Domain | R3H |
| Hgene | R3HCC1 | chr8:23147982 | chr19:42526506 | ENST00000518454 | + | 5 | 9 | 16_81 | 97 | 254.0 | Domain | R3H |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 860_866 | 491 | 981.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 860_866 | 491 | 982.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 860_866 | 491 | 981.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 566_622 | 491 | 981.0 | Topological domain | Cytoplasmic | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 644_803 | 491 | 981.0 | Topological domain | Extracellular | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 825_980 | 491 | 981.0 | Topological domain | Cytoplasmic | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 566_622 | 491 | 982.0 | Topological domain | Cytoplasmic | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 644_803 | 491 | 982.0 | Topological domain | Extracellular | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 825_980 | 491 | 982.0 | Topological domain | Cytoplasmic | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 566_622 | 491 | 981.0 | Topological domain | Cytoplasmic | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 644_803 | 491 | 981.0 | Topological domain | Extracellular | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 825_980 | 491 | 981.0 | Topological domain | Cytoplasmic | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 545_565 | 491 | 981.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 623_643 | 491 | 981.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 804_824 | 491 | 981.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 545_565 | 491 | 982.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 623_643 | 491 | 982.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 804_824 | 491 | 982.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 545_565 | 491 | 981.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 623_643 | 491 | 981.0 | Transmembrane | Helical | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 804_824 | 491 | 981.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | R3HCC1 | chr8:23147982 | chr19:42526506 | ENST00000265806 | + | 4 | 8 | 242_300 | 97 | 254.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | R3HCC1 | chr8:23147982 | chr19:42526506 | ENST00000518454 | + | 5 | 9 | 242_300 | 97 | 254.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000262895 | 10 | 19 | 15_544 | 491 | 981.0 | Topological domain | Extracellular | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000301218 | 10 | 19 | 15_544 | 491 | 982.0 | Topological domain | Extracellular | |
| Tgene | GRIK5 | chr8:23147982 | chr19:42526506 | ENST00000593562 | 11 | 20 | 15_544 | 491 | 981.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for R3HCC1-GRIK5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >71051_71051_1_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000265806_GRIK5_chr19_42526506_ENST00000262895_length(transcript)=3140nt_BP=1120nt TGTCTGGGTCTCGGTTTTGCCATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGTTTGTGTTGGTGGCAGGTGCGCCCCCTCC CAATAGGTGACAAGAACACGCACTCTCCCGTTCCTGCGTTACCTCCCCCAGGCCGCGCGGTGGCGCTGCGTCTCTGCAGCGGCCCGGGTC TCTCTAGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGCCGAGAGGCCGCGGCTCTCCCACCTGTCACCCT GGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCACCGGATCCAGGAGGAACTGGACCGCTTTCTGCT GCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTACCTGATCCATAGAACAGCAGAGAATTTTGATCT CTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAGGACATCAGGGTACCCAGTTCGGATGGCCTCTC TGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGTACCACGGTCCTCGGCCCATCTCCAACCAAGGAGCAGCTGCGGTTCCCCGAGG TGCCCGGGCTGGCCGGTGGTATCGTGGACGCAAGCCTGACCAGCCTTTGTATGTGCCCCGGGTGCTGCGCAGGCAGGAAGAATGGGGGCT GACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGCTGGCAGGGACCCAGAAGAGCCTGGAGATGTTGGTGCTGGAGACCCCAACTCTGA TCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGAGGACCTAAAGGGCCCAGGACAAAGGTGTGAGAATGAGCCACTGCTGGACCCTGT TGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGGGAAGGGAGACATGGTGGAGATGGCCACACGGTTTGGGTCCACCCTGCAGCTAGA CCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAGGCTGGTGGCAGAGGAGGAAGAGGACGAAGAGGAGGTGGAAGAGGATGGCCCCAG CAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCAGGAGAAGGCAGACCTGGCTGTGGCCGCCTTCACCATCACAGCTGAGCGGGAGAA GGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGGATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTT CCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTCAGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAG CCCCTATGAGTGGTATAACCCACACCCATGCCTGCGGGCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTT TCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACGCGCTGTGTCAGCGGAGTCTGGTGGGCCTTCAC CTTGATCATCATCTCCTCCTACACGGCCAACCTGGCCGCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCT GGCAGATCAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTCTTCCAGAATTCACGGTACCAAACGTACCAGCG CATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTGTTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGC CTTCCTGCTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACCCAGATCGGGGGACTCCTCGACACCAAGGGCTA CGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGATGAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCT GAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAAGGTTTGGGCATGGAGAACATTGGTGGCATTTT TATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTCGTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGA GGTGTCGGTGTGCCAGGAGATGCTGCAGGAGCTGCGCCACGCCGTTTCTTGCCGCAAGACGTCGCGTTCCCGCCGGCGCCGACGCCCGGG CGGCCCGAGCCGGGCCCTGCTGTCACTGCGCGCGGTCCGCGAGATGCGCCTCAGCAACGGCAAGCTCTACTCGGCCGGCGCGGGCGGGGA TGCGGGCAGCGCGCACGGGGGCCCGCAGCGCCTCCTGGACGACCCGGGGCCCCCCAGCGGAGCCCGACCCGCCGCCCCCACCCCCTGCAC CCACGTGCGCGTCTGCCAGGAGTGCCGGCGCATCCAGGCGCTGCGGGCCTCGGGGGCCGGCGCGCCTCCGCGTGGCCTGGGCGTCCCCGC CGAAGCCACCAGCCCGCCCCGGCCGCGGCCTGGCCCCGCCGGCCCCCGGGAGCTGGCGGAGCACGAGTGACCACGGGCGGGGCTGTGCGG GCGCCCGGACTGACCGAAGGGACGGGGCCCGCCCCAGGCCCCAGCAGTCTCCGCTCCCGCAGCGGGCGCGGGACAGGACTTGTGCGCCGG CGCCCCGGACGCCGCGATTTTGCCTTTGGTTCCCCGCGAAGTCCGAGGCCTGGCTCTGGAGCCCGCCTGCGCCCCCCAGTGGACTCGCGA GAGGGTGCCGCGGGCGAGAAGGGCGCAGGAACCGAGGACTCCAGGGGCTGGGGACTTCGGGGGCGGCTCTGGGAAGCGGAAAGCAGTCAG CGGAGAGGACCCCATTCTGGGACTGCTCAGGCTCCCCAAGACTTGACGCAGCCCCCCACGCTTCTGGAGGTGGGGAGGGCCTCTGGACAG ATGGGTGTCCCCTGGTGCCCCTCCACTCTTCTCTTCCTCTCTTTTTTGGGGGGAGAAACCTCGGAATTTCTATGAGACCTCCCCCAGGGA >71051_71051_1_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000265806_GRIK5_chr19_42526506_ENST00000262895_length(amino acids)=793AA_BP=296 MGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRYLIHRTAENFDLLSSFSVGEG WKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRYHGPRPISNQGAAAVPRGARAGRWYRGRKPDQPLYVPRVLRRQEEWGLTSTSVLKRE APAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRCENEPLLDPVGPEPLGPESQSGKGDMVEMATRFGSTLQLDLEKGKESLL EKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVW LFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTA NLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNE YHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLII AVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQ -------------------------------------------------------------- >71051_71051_2_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000265806_GRIK5_chr19_42526506_ENST00000301218_length(transcript)=2922nt_BP=1120nt TGTCTGGGTCTCGGTTTTGCCATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGTTTGTGTTGGTGGCAGGTGCGCCCCCTCC CAATAGGTGACAAGAACACGCACTCTCCCGTTCCTGCGTTACCTCCCCCAGGCCGCGCGGTGGCGCTGCGTCTCTGCAGCGGCCCGGGTC TCTCTAGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGCCGAGAGGCCGCGGCTCTCCCACCTGTCACCCT GGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCACCGGATCCAGGAGGAACTGGACCGCTTTCTGCT GCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTACCTGATCCATAGAACAGCAGAGAATTTTGATCT CTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAGGACATCAGGGTACCCAGTTCGGATGGCCTCTC TGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGTACCACGGTCCTCGGCCCATCTCCAACCAAGGAGCAGCTGCGGTTCCCCGAGG TGCCCGGGCTGGCCGGTGGTATCGTGGACGCAAGCCTGACCAGCCTTTGTATGTGCCCCGGGTGCTGCGCAGGCAGGAAGAATGGGGGCT GACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGCTGGCAGGGACCCAGAAGAGCCTGGAGATGTTGGTGCTGGAGACCCCAACTCTGA TCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGAGGACCTAAAGGGCCCAGGACAAAGGTGTGAGAATGAGCCACTGCTGGACCCTGT TGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGGGAAGGGAGACATGGTGGAGATGGCCACACGGTTTGGGTCCACCCTGCAGCTAGA CCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAGGCTGGTGGCAGAGGAGGAAGAGGACGAAGAGGAGGTGGAAGAGGATGGCCCCAG CAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCAGGAGAAGGCAGACCTGGCTGTGGCCGCCTTCACCATCACAGCTGAGCGGGAGAA GGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGGATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTT CCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTCAGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAG CCCCTATGAGTGGTATAACCCACACCCATGCCTGCGGGCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTT TCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACGCGCTGTGTCAGCGGAGTCTGGTGGGCCTTCAC CTTGATCATCATCTCCTCCTACACGGCCAACCTGGCCGCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCT GGCAGATCAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTCTTCCAGAATTCACGGTACCAAACGTACCAGCG CATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTGTTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGC CTTCCTGCTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACCCAGATCGGGGGACTCCTCGACACCAAGGGCTA CGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGATGAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCT GAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAAGGTTTGGGCATGGAGAACATTGGTGGCATTTT TATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTCGTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGA GACCCCAGCTCTGCATCCAGCTGCCTGCCAGTGTTCTGCACTTGGCCCAAGGACTCCTCTGAAGGAGCCGTCCATGCTGCTAGTAAAGGT GCCCTCCACCCGTGTCCAGGTTGCCTTCTCAAGGACATCCCTCCGGCAAGTCTGTCCTTTCCTCCTGCAGCATCAGTTGTCCTCTCTTTA TTGGATTCAGGCCACCAACGTACAAATATGCTGTCATTTCTCCAGTCTTAAACCCTCTCCTGACCTCACTTTCCCTCCCAGCCACCGCCC ACTTTCTTCCCTTCTCTTTACAGCCTTGGCAGCAGTGGGGGGTCTCCCTGATGCTTCCAGTTTCTTCTTTCCTCCCATTTCCTCTTGCCC CCCACTCCAGTCTGGCATCGGTCCCTGCCACTCCACTGAAGCCACTCTTGTCACCAGCAACTTCCATGTCTGAAATTCCCGGTCTCAGGC CTCATGTATATGAGGTAGCAGTGGGCTTCGGCACAGCCAGTCACTCTCAATCCTCAAAGCCCCTTCTTCCCCTTCTCCCACTTCTCCGGT CACTCCTTCCCAGGCTCCCTCGTTGGGTTTCTCTTTCTCCCCAGGCTCTGTTTGTTGTGGGGCTCCAGGGCTCAGTCCTTAGACTGCTTC TCTTCTCGGTCTTTCTCCACTACTTGAATGATCCCACCAGCCAAATGGCTCTTAAGACCCACTATGTGCTGGTGATTCTTGTGTTAGTTA >71051_71051_2_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000265806_GRIK5_chr19_42526506_ENST00000301218_length(amino acids)=794AA_BP=296 MGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRYLIHRTAENFDLLSSFSVGEG WKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRYHGPRPISNQGAAAVPRGARAGRWYRGRKPDQPLYVPRVLRRQEEWGLTSTSVLKRE APAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRCENEPLLDPVGPEPLGPESQSGKGDMVEMATRFGSTLQLDLEKGKESLL EKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVW LFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTA NLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNE YHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLII AVFVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQI -------------------------------------------------------------- >71051_71051_3_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000265806_GRIK5_chr19_42526506_ENST00000593562_length(transcript)=2647nt_BP=1120nt TGTCTGGGTCTCGGTTTTGCCATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGTTTGTGTTGGTGGCAGGTGCGCCCCCTCC CAATAGGTGACAAGAACACGCACTCTCCCGTTCCTGCGTTACCTCCCCCAGGCCGCGCGGTGGCGCTGCGTCTCTGCAGCGGCCCGGGTC TCTCTAGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGCCGAGAGGCCGCGGCTCTCCCACCTGTCACCCT GGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCACCGGATCCAGGAGGAACTGGACCGCTTTCTGCT GCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTACCTGATCCATAGAACAGCAGAGAATTTTGATCT CTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAGGACATCAGGGTACCCAGTTCGGATGGCCTCTC TGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGTACCACGGTCCTCGGCCCATCTCCAACCAAGGAGCAGCTGCGGTTCCCCGAGG TGCCCGGGCTGGCCGGTGGTATCGTGGACGCAAGCCTGACCAGCCTTTGTATGTGCCCCGGGTGCTGCGCAGGCAGGAAGAATGGGGGCT GACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGCTGGCAGGGACCCAGAAGAGCCTGGAGATGTTGGTGCTGGAGACCCCAACTCTGA TCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGAGGACCTAAAGGGCCCAGGACAAAGGTGTGAGAATGAGCCACTGCTGGACCCTGT TGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGGGAAGGGAGACATGGTGGAGATGGCCACACGGTTTGGGTCCACCCTGCAGCTAGA CCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAGGCTGGTGGCAGAGGAGGAAGAGGACGAAGAGGAGGTGGAAGAGGATGGCCCCAG CAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCAGGAGAAGGCAGACCTGGCTGTGGCCGCCTTCACCATCACAGCTGAGCGGGAGAA GGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGGATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTT CCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTCAGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAG CCCCTATGAGTGGTATAACCCACACCCATGCCTGCGGGCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTT TCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACGCGCTGTGTCAGCGGAGTCTGGTGGGCCTTCAC CTTGATCATCATCTCCTCCTACACGGCCAACCTGGCCGCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCT GGCAGATCAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTCTTCCAGAATTCACGGTACCAAACGTACCAGCG CATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTGTTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGC CTTCCTGCTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACCCAGATCGGGGGACTCCTCGACACCAAGGGCTA CGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGATGAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCT GAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAAGGTTTGGGCATGGAGAACATTGGTGGCATTTT TATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTCGTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGA GGTGTCGGTGTGCCAGGAGATGCTGCAGGAGCTGCGCCACGCCGTTTCTTGCCGCAAGACGTCGCGTTCCCGCCGGCGCCGACGCCCGGG CGGCCCGAGCCGGGCCCTGCTGTCACTGCGCGCGGTCCGCGAGATGCGCCTCAGCAACGGCAAGCTCTACTCGGCCGGCGCGGGCGGGGA TGCGGGCAGCGCGCACGGGGGCCCGCAGCGCCTCCTGGACGACCCGGGGCCCCCCAGCGGAGCCCGACCCGCCGCCCCCACCCCCTGCAC CCACGTGCGCGTCTGCCAGGAGTGCCGGCGCATCCAGGCGCTGCGGGCCTCGGGGGCCGGCGCGCCTCCGCGTGGCCTGGGCGTCCCCGC CGAAGCCACCAGCCCGCCCCGGCCGCGGCCTGGCCCCGCCGGCCCCCGGGAGCTGGCGGAGCACGAGTGACCACGGGCGGGGCTGTGCGG >71051_71051_3_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000265806_GRIK5_chr19_42526506_ENST00000593562_length(amino acids)=793AA_BP=296 MGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRYLIHRTAENFDLLSSFSVGEG WKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRYHGPRPISNQGAAAVPRGARAGRWYRGRKPDQPLYVPRVLRRQEEWGLTSTSVLKRE APAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRCENEPLLDPVGPEPLGPESQSGKGDMVEMATRFGSTLQLDLEKGKESLL EKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVW LFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTA NLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNE YHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLII AVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQ -------------------------------------------------------------- >71051_71051_4_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000411463_GRIK5_chr19_42526506_ENST00000262895_length(transcript)=2992nt_BP=972nt ATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGC CGAGAGGCCGCGGCTCTCCCACCTGTCACCCTGGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCAC CGGATCCAGGAGGAACTGGACCGCTTTCTGCTGCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTAC CTGATCCATAGAACAGCAGAGAATTTTGATCTCTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAG GACATCAGGGTACCCAGTTCGGATGGCCTCTCTGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGTACCACGGTCCTCGGCCCATC TCCAACCAAGGAGCAGCTGCGGTTCCCCGAGGTGCCCGGGCTGGCCGGTGGTATCGTGGACGCAAGCCTGACCAGCCTTTGTATGTGCCC CGGGTGCTGCGCAGGCAGGAAGAATGGGGGCTGACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGCTGGCAGGGACCCAGAAGAGCCT GGAGATGTTGGTGCTGGAGACCCCAACTCTGATCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGAGGACCTAAAGGGCCCAGGACAA AGGTGTGAGAATGAGCCACTGCTGGACCCTGTTGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGGGAAGGGAGACATGGTGGAGATG GCCACACGGTTTGGGTCCACCCTGCAGCTAGACCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAGGCTGGTGGCAGAGGAGGAAGAG GACGAAGAGGAGGTGGAAGAGGATGGCCCCAGCAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCAGGAGAAGGCAGACCTGGCTGTG GCCGCCTTCACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGGATCAGCATCCTCTACCGAGTG CACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTC AGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCGGGCACGCCCCCACATCCTGGAG AACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACG CGCTGTGTCAGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGCCGCCTTCCTCACCGTGCAGCGC ATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGATCAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTC TTCCAGAATTCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTGTTCGTCAAGAGCACAGAAGAG GGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTGCTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACC CAGATCGGGGGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGATGAGATCACACTGGCCATCCTG CAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAA GGTTTGGGCATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTCGTGGCGGTCATGGAATTCATA TGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGGTGTCGGTGTGCCAGGAGATGCTGCAGGAGCTGCGCCACGCCGTTTCTTGCCGCAAG ACGTCGCGTTCCCGCCGGCGCCGACGCCCGGGCGGCCCGAGCCGGGCCCTGCTGTCACTGCGCGCGGTCCGCGAGATGCGCCTCAGCAAC GGCAAGCTCTACTCGGCCGGCGCGGGCGGGGATGCGGGCAGCGCGCACGGGGGCCCGCAGCGCCTCCTGGACGACCCGGGGCCCCCCAGC GGAGCCCGACCCGCCGCCCCCACCCCCTGCACCCACGTGCGCGTCTGCCAGGAGTGCCGGCGCATCCAGGCGCTGCGGGCCTCGGGGGCC GGCGCGCCTCCGCGTGGCCTGGGCGTCCCCGCCGAAGCCACCAGCCCGCCCCGGCCGCGGCCTGGCCCCGCCGGCCCCCGGGAGCTGGCG GAGCACGAGTGACCACGGGCGGGGCTGTGCGGGCGCCCGGACTGACCGAAGGGACGGGGCCCGCCCCAGGCCCCAGCAGTCTCCGCTCCC GCAGCGGGCGCGGGACAGGACTTGTGCGCCGGCGCCCCGGACGCCGCGATTTTGCCTTTGGTTCCCCGCGAAGTCCGAGGCCTGGCTCTG GAGCCCGCCTGCGCCCCCCAGTGGACTCGCGAGAGGGTGCCGCGGGCGAGAAGGGCGCAGGAACCGAGGACTCCAGGGGCTGGGGACTTC GGGGGCGGCTCTGGGAAGCGGAAAGCAGTCAGCGGAGAGGACCCCATTCTGGGACTGCTCAGGCTCCCCAAGACTTGACGCAGCCCCCCA CGCTTCTGGAGGTGGGGAGGGCCTCTGGACAGATGGGTGTCCCCTGGTGCCCCTCCACTCTTCTCTTCCTCTCTTTTTTGGGGGGAGAAA CCTCGGAATTTCTATGAGACCTCCCCCAGGGAGGGGGTCAGTTGGGCCCCCATCCCTCCCCTTGCCACATCGCAGCCCCTGTTGGAATAA >71051_71051_4_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000411463_GRIK5_chr19_42526506_ENST00000262895_length(amino acids)=813AA_BP=316 MNMKASRVTLGEAGARARWPLGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRY LIHRTAENFDLLSSFSVGEGWKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRYHGPRPISNQGAAAVPRGARAGRWYRGRKPDQPLYVP RVLRRQEEWGLTSTSVLKREAPAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRCENEPLLDPVGPEPLGPESQSGKGDMVEM ATRFGSTLQLDLEKGKESLLEKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRV HMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALST RCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEE GIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK GLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSN GKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELA -------------------------------------------------------------- >71051_71051_5_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000411463_GRIK5_chr19_42526506_ENST00000301218_length(transcript)=2774nt_BP=972nt ATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGC CGAGAGGCCGCGGCTCTCCCACCTGTCACCCTGGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCAC CGGATCCAGGAGGAACTGGACCGCTTTCTGCTGCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTAC CTGATCCATAGAACAGCAGAGAATTTTGATCTCTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAG GACATCAGGGTACCCAGTTCGGATGGCCTCTCTGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGTACCACGGTCCTCGGCCCATC TCCAACCAAGGAGCAGCTGCGGTTCCCCGAGGTGCCCGGGCTGGCCGGTGGTATCGTGGACGCAAGCCTGACCAGCCTTTGTATGTGCCC CGGGTGCTGCGCAGGCAGGAAGAATGGGGGCTGACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGCTGGCAGGGACCCAGAAGAGCCT GGAGATGTTGGTGCTGGAGACCCCAACTCTGATCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGAGGACCTAAAGGGCCCAGGACAA AGGTGTGAGAATGAGCCACTGCTGGACCCTGTTGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGGGAAGGGAGACATGGTGGAGATG GCCACACGGTTTGGGTCCACCCTGCAGCTAGACCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAGGCTGGTGGCAGAGGAGGAAGAG GACGAAGAGGAGGTGGAAGAGGATGGCCCCAGCAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCAGGAGAAGGCAGACCTGGCTGTG GCCGCCTTCACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGGATCAGCATCCTCTACCGAGTG CACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTC AGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCGGGCACGCCCCCACATCCTGGAG AACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACG CGCTGTGTCAGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGCCGCCTTCCTCACCGTGCAGCGC ATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGATCAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTC TTCCAGAATTCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTGTTCGTCAAGAGCACAGAAGAG GGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTGCTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACC CAGATCGGGGGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGATGAGATCACACTGGCCATCCTG CAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAA GGTTTGGGCATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTCGTGGCGGTCATGGAATTCATA TGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGACCCCAGCTCTGCATCCAGCTGCCTGCCAGTGTTCTGCACTTGGCCCAAGGACTCCT CTGAAGGAGCCGTCCATGCTGCTAGTAAAGGTGCCCTCCACCCGTGTCCAGGTTGCCTTCTCAAGGACATCCCTCCGGCAAGTCTGTCCT TTCCTCCTGCAGCATCAGTTGTCCTCTCTTTATTGGATTCAGGCCACCAACGTACAAATATGCTGTCATTTCTCCAGTCTTAAACCCTCT CCTGACCTCACTTTCCCTCCCAGCCACCGCCCACTTTCTTCCCTTCTCTTTACAGCCTTGGCAGCAGTGGGGGGTCTCCCTGATGCTTCC AGTTTCTTCTTTCCTCCCATTTCCTCTTGCCCCCCACTCCAGTCTGGCATCGGTCCCTGCCACTCCACTGAAGCCACTCTTGTCACCAGC AACTTCCATGTCTGAAATTCCCGGTCTCAGGCCTCATGTATATGAGGTAGCAGTGGGCTTCGGCACAGCCAGTCACTCTCAATCCTCAAA GCCCCTTCTTCCCCTTCTCCCACTTCTCCGGTCACTCCTTCCCAGGCTCCCTCGTTGGGTTTCTCTTTCTCCCCAGGCTCTGTTTGTTGT GGGGCTCCAGGGCTCAGTCCTTAGACTGCTTCTCTTCTCGGTCTTTCTCCACTACTTGAATGATCCCACCAGCCAAATGGCTCTTAAGAC >71051_71051_5_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000411463_GRIK5_chr19_42526506_ENST00000301218_length(amino acids)=814AA_BP=316 MNMKASRVTLGEAGARARWPLGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRY LIHRTAENFDLLSSFSVGEGWKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRYHGPRPISNQGAAAVPRGARAGRWYRGRKPDQPLYVP RVLRRQEEWGLTSTSVLKREAPAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRCENEPLLDPVGPEPLGPESQSGKGDMVEM ATRFGSTLQLDLEKGKESLLEKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRV HMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALST RCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEE GIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK GLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQVCP FLLQHQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALAAVGGLPDASSFFFPPISSCPPLQSGIGPCHSTEATLVTS -------------------------------------------------------------- >71051_71051_6_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000411463_GRIK5_chr19_42526506_ENST00000593562_length(transcript)=2499nt_BP=972nt ATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGC CGAGAGGCCGCGGCTCTCCCACCTGTCACCCTGGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCAC CGGATCCAGGAGGAACTGGACCGCTTTCTGCTGCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTAC CTGATCCATAGAACAGCAGAGAATTTTGATCTCTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAG GACATCAGGGTACCCAGTTCGGATGGCCTCTCTGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGTACCACGGTCCTCGGCCCATC TCCAACCAAGGAGCAGCTGCGGTTCCCCGAGGTGCCCGGGCTGGCCGGTGGTATCGTGGACGCAAGCCTGACCAGCCTTTGTATGTGCCC CGGGTGCTGCGCAGGCAGGAAGAATGGGGGCTGACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGCTGGCAGGGACCCAGAAGAGCCT GGAGATGTTGGTGCTGGAGACCCCAACTCTGATCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGAGGACCTAAAGGGCCCAGGACAA AGGTGTGAGAATGAGCCACTGCTGGACCCTGTTGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGGGAAGGGAGACATGGTGGAGATG GCCACACGGTTTGGGTCCACCCTGCAGCTAGACCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAGGCTGGTGGCAGAGGAGGAAGAG GACGAAGAGGAGGTGGAAGAGGATGGCCCCAGCAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCAGGAGAAGGCAGACCTGGCTGTG GCCGCCTTCACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGGATCAGCATCCTCTACCGAGTG CACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTC AGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCGGGCACGCCCCCACATCCTGGAG AACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACG CGCTGTGTCAGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGCCGCCTTCCTCACCGTGCAGCGC ATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGATCAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTC TTCCAGAATTCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTGTTCGTCAAGAGCACAGAAGAG GGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTGCTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACC CAGATCGGGGGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGATGAGATCACACTGGCCATCCTG CAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAA GGTTTGGGCATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTCGTGGCGGTCATGGAATTCATA TGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGGTGTCGGTGTGCCAGGAGATGCTGCAGGAGCTGCGCCACGCCGTTTCTTGCCGCAAG ACGTCGCGTTCCCGCCGGCGCCGACGCCCGGGCGGCCCGAGCCGGGCCCTGCTGTCACTGCGCGCGGTCCGCGAGATGCGCCTCAGCAAC GGCAAGCTCTACTCGGCCGGCGCGGGCGGGGATGCGGGCAGCGCGCACGGGGGCCCGCAGCGCCTCCTGGACGACCCGGGGCCCCCCAGC GGAGCCCGACCCGCCGCCCCCACCCCCTGCACCCACGTGCGCGTCTGCCAGGAGTGCCGGCGCATCCAGGCGCTGCGGGCCTCGGGGGCC GGCGCGCCTCCGCGTGGCCTGGGCGTCCCCGCCGAAGCCACCAGCCCGCCCCGGCCGCGGCCTGGCCCCGCCGGCCCCCGGGAGCTGGCG >71051_71051_6_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000411463_GRIK5_chr19_42526506_ENST00000593562_length(amino acids)=813AA_BP=316 MNMKASRVTLGEAGARARWPLGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRY LIHRTAENFDLLSSFSVGEGWKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRYHGPRPISNQGAAAVPRGARAGRWYRGRKPDQPLYVP RVLRRQEEWGLTSTSVLKREAPAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRCENEPLLDPVGPEPLGPESQSGKGDMVEM ATRFGSTLQLDLEKGKESLLEKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRV HMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALST RCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEE GIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK GLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSN GKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELA -------------------------------------------------------------- >71051_71051_7_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000518454_GRIK5_chr19_42526506_ENST00000262895_length(transcript)=3014nt_BP=994nt TGTCTGGGTCTCGGTTTTGCCATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGTTTGTGTTGGTGGCAGGTGCGCCCCCTCC CAATAGGTGACAAGAACACGCACTCTCCCGTTCCTGCGTTACCTCCCCCAGGCCGCGCGGTGGCGCTGCGTCTCTGCAGCGGCCCGGGTC TCTCTAGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGCCGAGAGGCCGCGGCTCTCCCACCTGTCACCCT GGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCACCGGATCCAGGAGGAACTGGACCGCTTTCTGCT GCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTACCTGATCCATAGAACAGCAGAGAATTTTGATCT CTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAGGACATCAGGGTACCCAGTTCGGATGGCCTCTC TGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGCAGGAAGAATGGGGGCTGACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGC TGGCAGGGACCCAGAAGAGCCTGGAGATGTTGGTGCTGGAGACCCCAACTCTGATCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGA GGACCTAAAGGGCCCAGGACAAAGGTGTGAGAATGAGCCACTGCTGGACCCTGTTGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGG GAAGGGAGACATGGTGGAGATGGCCACACGGTTTGGGTCCACCCTGCAGCTAGACCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAG GCTGGTGGCAGAGGAGGAAGAGGACGAAGAGGAGGTGGAAGAGGATGGCCCCAGCAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCA GGAGAAGGCAGACCTGGCTGTGGCCGCCTTCACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGG GATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCAT GCTTCTTGCCTACCTGGCTGTCAGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCG GGCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGAT CATGCCCCGGGCGCTGTCCACGCGCTGTGTCAGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGC CGCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGATCAGACCAACATCGAGTATGGCACCATCCA CGCCGGCTCCACCATGACCTTCTTCCAGAATTCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGT GTTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTGCTCGAGTCCACCATGAACGAATACCACCG GCGCCTCAACTGCAACCTCACCCAGATCGGGGGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGA TGAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAA GGAGGAGGACCATCGAGCTAAAGGTTTGGGCATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTT CGTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGGTGTCGGTGTGCCAGGAGATGCTGCAGGAGCTGCG CCACGCCGTTTCTTGCCGCAAGACGTCGCGTTCCCGCCGGCGCCGACGCCCGGGCGGCCCGAGCCGGGCCCTGCTGTCACTGCGCGCGGT CCGCGAGATGCGCCTCAGCAACGGCAAGCTCTACTCGGCCGGCGCGGGCGGGGATGCGGGCAGCGCGCACGGGGGCCCGCAGCGCCTCCT GGACGACCCGGGGCCCCCCAGCGGAGCCCGACCCGCCGCCCCCACCCCCTGCACCCACGTGCGCGTCTGCCAGGAGTGCCGGCGCATCCA GGCGCTGCGGGCCTCGGGGGCCGGCGCGCCTCCGCGTGGCCTGGGCGTCCCCGCCGAAGCCACCAGCCCGCCCCGGCCGCGGCCTGGCCC CGCCGGCCCCCGGGAGCTGGCGGAGCACGAGTGACCACGGGCGGGGCTGTGCGGGCGCCCGGACTGACCGAAGGGACGGGGCCCGCCCCA GGCCCCAGCAGTCTCCGCTCCCGCAGCGGGCGCGGGACAGGACTTGTGCGCCGGCGCCCCGGACGCCGCGATTTTGCCTTTGGTTCCCCG CGAAGTCCGAGGCCTGGCTCTGGAGCCCGCCTGCGCCCCCCAGTGGACTCGCGAGAGGGTGCCGCGGGCGAGAAGGGCGCAGGAACCGAG GACTCCAGGGGCTGGGGACTTCGGGGGCGGCTCTGGGAAGCGGAAAGCAGTCAGCGGAGAGGACCCCATTCTGGGACTGCTCAGGCTCCC CAAGACTTGACGCAGCCCCCCACGCTTCTGGAGGTGGGGAGGGCCTCTGGACAGATGGGTGTCCCCTGGTGCCCCTCCACTCTTCTCTTC CTCTCTTTTTTGGGGGGAGAAACCTCGGAATTTCTATGAGACCTCCCCCAGGGAGGGGGTCAGTTGGGCCCCCATCCCTCCCCTTGCCAC >71051_71051_7_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000518454_GRIK5_chr19_42526506_ENST00000262895_length(amino acids)=751AA_BP=254 MGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRYLIHRTAENFDLLSSFSVGEG WKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRQEEWGLTSTSVLKREAPAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRC ENEPLLDPVGPEPLGPESQSGKGDMVEMATRFGSTLQLDLEKGKESLLEKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAA FTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQ YTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQ NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQL QENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTS RSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGA -------------------------------------------------------------- >71051_71051_8_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000518454_GRIK5_chr19_42526506_ENST00000301218_length(transcript)=2796nt_BP=994nt TGTCTGGGTCTCGGTTTTGCCATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGTTTGTGTTGGTGGCAGGTGCGCCCCCTCC CAATAGGTGACAAGAACACGCACTCTCCCGTTCCTGCGTTACCTCCCCCAGGCCGCGCGGTGGCGCTGCGTCTCTGCAGCGGCCCGGGTC TCTCTAGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGCCGAGAGGCCGCGGCTCTCCCACCTGTCACCCT GGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCACCGGATCCAGGAGGAACTGGACCGCTTTCTGCT GCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTACCTGATCCATAGAACAGCAGAGAATTTTGATCT CTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAGGACATCAGGGTACCCAGTTCGGATGGCCTCTC TGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGCAGGAAGAATGGGGGCTGACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGC TGGCAGGGACCCAGAAGAGCCTGGAGATGTTGGTGCTGGAGACCCCAACTCTGATCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGA GGACCTAAAGGGCCCAGGACAAAGGTGTGAGAATGAGCCACTGCTGGACCCTGTTGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGG GAAGGGAGACATGGTGGAGATGGCCACACGGTTTGGGTCCACCCTGCAGCTAGACCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAG GCTGGTGGCAGAGGAGGAAGAGGACGAAGAGGAGGTGGAAGAGGATGGCCCCAGCAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCA GGAGAAGGCAGACCTGGCTGTGGCCGCCTTCACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGG GATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCAT GCTTCTTGCCTACCTGGCTGTCAGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCG GGCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGAT CATGCCCCGGGCGCTGTCCACGCGCTGTGTCAGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGC CGCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGATCAGACCAACATCGAGTATGGCACCATCCA CGCCGGCTCCACCATGACCTTCTTCCAGAATTCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGT GTTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTGCTCGAGTCCACCATGAACGAATACCACCG GCGCCTCAACTGCAACCTCACCCAGATCGGGGGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGA TGAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAA GGAGGAGGACCATCGAGCTAAAGGTTTGGGCATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTT CGTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGACCCCAGCTCTGCATCCAGCTGCCTGCCAGTGTTC TGCACTTGGCCCAAGGACTCCTCTGAAGGAGCCGTCCATGCTGCTAGTAAAGGTGCCCTCCACCCGTGTCCAGGTTGCCTTCTCAAGGAC ATCCCTCCGGCAAGTCTGTCCTTTCCTCCTGCAGCATCAGTTGTCCTCTCTTTATTGGATTCAGGCCACCAACGTACAAATATGCTGTCA TTTCTCCAGTCTTAAACCCTCTCCTGACCTCACTTTCCCTCCCAGCCACCGCCCACTTTCTTCCCTTCTCTTTACAGCCTTGGCAGCAGT GGGGGGTCTCCCTGATGCTTCCAGTTTCTTCTTTCCTCCCATTTCCTCTTGCCCCCCACTCCAGTCTGGCATCGGTCCCTGCCACTCCAC TGAAGCCACTCTTGTCACCAGCAACTTCCATGTCTGAAATTCCCGGTCTCAGGCCTCATGTATATGAGGTAGCAGTGGGCTTCGGCACAG CCAGTCACTCTCAATCCTCAAAGCCCCTTCTTCCCCTTCTCCCACTTCTCCGGTCACTCCTTCCCAGGCTCCCTCGTTGGGTTTCTCTTT CTCCCCAGGCTCTGTTTGTTGTGGGGCTCCAGGGCTCAGTCCTTAGACTGCTTCTCTTCTCGGTCTTTCTCCACTACTTGAATGATCCCA CCAGCCAAATGGCTCTTAAGACCCACTATGTGCTGGTGATTCTTGTGTTAGTTATCTATTGCTATCATAACAAATGACCTTAACAGCTTT >71051_71051_8_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000518454_GRIK5_chr19_42526506_ENST00000301218_length(amino acids)=752AA_BP=254 MGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRYLIHRTAENFDLLSSFSVGEG WKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRQEEWGLTSTSVLKREAPAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRC ENEPLLDPVGPEPLGPESQSGKGDMVEMATRFGSTLQLDLEKGKESLLEKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAA FTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQ YTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQ NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQL QENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLK EPSMLLVKVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALAAVGGLPDASSF -------------------------------------------------------------- >71051_71051_9_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000518454_GRIK5_chr19_42526506_ENST00000593562_length(transcript)=2521nt_BP=994nt TGTCTGGGTCTCGGTTTTGCCATGAATATGAAAGCTAGTCGTGTCACTCTAGGAGAAGCGGTTTGTGTTGGTGGCAGGTGCGCCCCCTCC CAATAGGTGACAAGAACACGCACTCTCCCGTTCCTGCGTTACCTCCCCCAGGCCGCGCGGTGGCGCTGCGTCTCTGCAGCGGCCCGGGTC TCTCTAGGGCGCTCGGGCGCGCTGGCCCCTGGGGACGCCGAGGGCGGCTGCGACGCGCCGAGAGGCCGCGGCTCTCCCACCTGTCACCCT GGCCCTTCTCTGCTTGGATGGTGTCTTCCTCTCCTCAGCCGAGAATGACTTCGTCCACCGGATCCAGGAGGAACTGGACCGCTTTCTGCT GCAGAAGCAGCTGTCAAAGGTTCTTCTTTTCCCCCCACTCTCCAGTCGCCTCCGGTACCTGATCCATAGAACAGCAGAGAATTTTGATCT CTTGAGCAGCTTCTCCGTTGGGGAGGGCTGGAAGAGGAGGACGGTCATCTGTCACCAGGACATCAGGGTACCCAGTTCGGATGGCCTCTC TGGCCCCTGCCGCGCTCCTGCCTCCTGCCCCAGCAGGCAGGAAGAATGGGGGCTGACCTCTACCTCGGTGCTCAAGAGAGAGGCCCCAGC TGGCAGGGACCCAGAAGAGCCTGGAGATGTTGGTGCTGGAGACCCCAACTCTGATCAGGGACTCCCTGTGCTGATGACTCAGGGAACAGA GGACCTAAAGGGCCCAGGACAAAGGTGTGAGAATGAGCCACTGCTGGACCCTGTTGGCCCTGAGCCTCTGGGGCCTGAGAGTCAGTCAGG GAAGGGAGACATGGTGGAGATGGCCACACGGTTTGGGTCCACCCTGCAGCTAGACCTGGAAAAGGGGAAGGAGAGTCTGTTGGAGAAGAG GCTGGTGGCAGAGGAGGAAGAGGACGAAGAGGAGGTGGAAGAGGATGGCCCCAGCAGCTGCTCGGAGGACGATTACAGTGAGCTGCTGCA GGAGAAGGCAGACCTGGCTGTGGCCGCCTTCACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGG GATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGACCCCTTCTCCCCTGCTGTGTGGCTCTTCAT GCTTCTTGCCTACCTGGCTGTCAGCTGCGTCCTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCG GGCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTGGGGGGCTTCATGCAGCAGGGCTCGGAGAT CATGCCCCGGGCGCTGTCCACGCGCTGTGTCAGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGC CGCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGATCAGACCAACATCGAGTATGGCACCATCCA CGCCGGCTCCACCATGACCTTCTTCCAGAATTCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGT GTTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTGCTCGAGTCCACCATGAACGAATACCACCG GCGCCTCAACTGCAACCTCACCCAGATCGGGGGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGA TGAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGCAAGTGGTGGGAGGGGGGCCGGTGCCCCAA GGAGGAGGACCATCGAGCTAAAGGTTTGGGCATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTT CGTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGGTGTCGGTGTGCCAGGAGATGCTGCAGGAGCTGCG CCACGCCGTTTCTTGCCGCAAGACGTCGCGTTCCCGCCGGCGCCGACGCCCGGGCGGCCCGAGCCGGGCCCTGCTGTCACTGCGCGCGGT CCGCGAGATGCGCCTCAGCAACGGCAAGCTCTACTCGGCCGGCGCGGGCGGGGATGCGGGCAGCGCGCACGGGGGCCCGCAGCGCCTCCT GGACGACCCGGGGCCCCCCAGCGGAGCCCGACCCGCCGCCCCCACCCCCTGCACCCACGTGCGCGTCTGCCAGGAGTGCCGGCGCATCCA GGCGCTGCGGGCCTCGGGGGCCGGCGCGCCTCCGCGTGGCCTGGGCGTCCCCGCCGAAGCCACCAGCCCGCCCCGGCCGCGGCCTGGCCC CGCCGGCCCCCGGGAGCTGGCGGAGCACGAGTGACCACGGGCGGGGCTGTGCGGGCGCCCGGACTGACCGAAGGGACGGGGCCCGCCCCA >71051_71051_9_R3HCC1-GRIK5_R3HCC1_chr8_23147982_ENST00000518454_GRIK5_chr19_42526506_ENST00000593562_length(amino acids)=751AA_BP=254 MGTPRAAATRREAAALPPVTLALLCLDGVFLSSAENDFVHRIQEELDRFLLQKQLSKVLLFPPLSSRLRYLIHRTAENFDLLSSFSVGEG WKRRTVICHQDIRVPSSDGLSGPCRAPASCPSRQEEWGLTSTSVLKREAPAGRDPEEPGDVGAGDPNSDQGLPVLMTQGTEDLKGPGQRC ENEPLLDPVGPEPLGPESQSGKGDMVEMATRFGSTLQLDLEKGKESLLEKRLVAEEEEDEEEVEEDGPSSCSEDDYSELLQEKADLAVAA FTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQ YTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQ NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQL QENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTS RSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for R3HCC1-GRIK5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for R3HCC1-GRIK5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for R3HCC1-GRIK5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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