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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:R3HDM4-TMEM259 (FusionGDB2 ID:71107)

Fusion Gene Summary for R3HDM4-TMEM259

Fusion gene summary

Fusion gene information	Fusion gene name: R3HDM4-TMEM259
	Fusion gene ID: 71107
		Hgene	Tgene
	Gene symbol	R3HDM4	TMEM259
	Gene ID	91300	91304
	Gene name	R3H domain containing 4	transmembrane protein 259
	Synonyms	C19orf22	ASBABP1\|C19orf6\|MBRL\|MEMBRALIN\|R32184_3
	Cytomap	19p13.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	R3H domain-containing protein 4R3H domain-containing protein C19orf22	membralinaspecific BCL2 ARE-binding protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q96D70	Q4ZIN3
	Ensembl transtripts involved in fusion gene	ENST00000361574, ENST00000587975,	ENST00000356663, ENST00000333175,
Fusion gene scores	* DoF score	4 X 3 X 5=60	6 X 6 X 5=180
	# samples	7	8
	** MAII score	log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: R3HDM4 [Title/Abstract] AND TMEM259 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	R3HDM4(913087)-TMEM259(1014472), # samples:1 R3HDM4(913087)-TMEM259(1010894), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across R3HDM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMEM259 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-ZF-AA51-01A	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-
ChimerDB4	GBM	TCGA-14-1402-02A	R3HDM4	chr19	913087	-	TMEM259	chr19	1010894	-

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Fusion Gene ORF analysis for R3HDM4-TMEM259

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000361574	ENST00000356663	R3HDM4	chr19	913087	-	TMEM259	chr19	1010894	-
Frame-shift	ENST00000587975	ENST00000356663	R3HDM4	chr19	913087	-	TMEM259	chr19	1010894	-
In-frame	ENST00000361574	ENST00000333175	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-
In-frame	ENST00000361574	ENST00000333175	R3HDM4	chr19	913087	-	TMEM259	chr19	1010894	-
In-frame	ENST00000361574	ENST00000356663	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-
In-frame	ENST00000587975	ENST00000333175	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-
In-frame	ENST00000587975	ENST00000333175	R3HDM4	chr19	913087	-	TMEM259	chr19	1010894	-
In-frame	ENST00000587975	ENST00000356663	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361574	R3HDM4	chr19	913087	-	ENST00000356663	TMEM259	chr19	1014472	-	2485	145	148	1782	544
ENST00000361574	R3HDM4	chr19	913087	-	ENST00000333175	TMEM259	chr19	1014472	-	2382	145	148	1146	332
ENST00000587975	R3HDM4	chr19	913087	-	ENST00000356663	TMEM259	chr19	1014472	-	2494	154	157	1791	544
ENST00000587975	R3HDM4	chr19	913087	-	ENST00000333175	TMEM259	chr19	1014472	-	2391	154	157	1155	332

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361574	ENST00000356663	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-	0.005486656	0.9945134
ENST00000361574	ENST00000333175	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-	0.005047562	0.99495244
ENST00000587975	ENST00000356663	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-	0.00545833	0.9945417
ENST00000587975	ENST00000333175	R3HDM4	chr19	913087	-	TMEM259	chr19	1014472	-	0.00448713	0.9955129

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Fusion Genomic Features for R3HDM4-TMEM259

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for R3HDM4-TMEM259

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:913087/chr19:1014472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
R3HDM4 Q96D70	TMEM259 Q4ZIN3
	FUNCTION: May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. {ECO:0000250\|UniProtKB:Q8CIV2}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000333175

426_446

405

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000333175

302_322

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000333175

346_366

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000333175

426_446

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000356663

302_322

621.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000356663

346_366

621.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000356663

426_446

621.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

R3HDM4

chr19:913087

chr19:1010894

ENST00000361574

132_184

269.0

Compositional bias

Note=Arg-rich

Hgene

R3HDM4

chr19:913087

chr19:1014472

ENST00000361574

132_184

269.0

Compositional bias

Note=Arg-rich

Hgene

R3HDM4

chr19:913087

chr19:1010894

ENST00000361574

187_250

269.0

Domain

R3H

Hgene

R3HDM4

chr19:913087

chr19:1014472

ENST00000361574

187_250

269.0

Domain

R3H

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000333175

302_322

405

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000333175

346_366

405

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000333175

70_90

405

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000356663

302_322

439

621.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000356663

346_366

439

621.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000356663

426_446

439

621.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1010894

ENST00000356663

70_90

439

621.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000333175

70_90

409.0

Transmembrane

Helical

Tgene

TMEM259

chr19:913087

chr19:1014472

ENST00000356663

70_90

621.0

Transmembrane

Helical

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Fusion Gene Sequence for R3HDM4-TMEM259

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>71107_71107_1_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000361574_TMEM259_chr19_1014472_ENST00000333175_length(transcript)=2382nt_BP=145nt
CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA
ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTGCCCTGTTTGTGCTCTTCGTCCTGGCCTACATCCA
CATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCGCGTGAGGGCATCCTGCGTGTGGAAGTGCGGCA
CAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGCTTCCCGGGCCTGGCCGTGGAACCAGGCAGCAA
CCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGCTCCATCAAGTTTGAGCTGGACATCGAGCCCAA
GGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTCCCCGAGACGCCCACCAAAGTGTGGCCGCAGGA
CGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACCCGCCAGCGCCTGAGCATCCCCGTCATGGTGGT
CACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTGGATGAGTTCCTGGGCTACGATGACATCCTCAT
GTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTGGTGTCGGGCGAGCACTACCGCTTTGTGAGCAT
GTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTGAGCGTGTCCATGCTGCTGCGGTACTCACACCA
CCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATCGCCTTCCCCGCAGCGCCCCTGCTGACCGTCAT
CCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACCGCCTTCTACATCATCCTCATCGTGTGGCTCGC
GGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGCATTCCATGATCTACTTCTTCCACCACTACGAG
CTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAGGCGCCGCCACTGGGCCCCGGGACCCCCACGGCGCTGCCCGAT
GACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCCGGCCAGCCCCCCGCCCTGGGCCCCGTCTCGCCTGGGGCCAGC
GGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCGGCAGCCTCAGTGGCAGCAGCTGCCGGTGGTGACCTGGGTTGG
ATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGCCTGAGCGCCTCCCTCCTGGAGCGGCGTCCAGCCAGCCCGCTG
GGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCGAGTGACTCCGCAGCTTCTGACACAACTCCCCTGGGGGCTGCG
GTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCGGAGGTGGGGTCCTGAGCCGCACAGCTGAGCCGCCTCTGACCC
CTGCTGGCTGGGCCTGACCTTCCCGAGCCCGTGGGGGTGGGGGAGGCCAGCCACCTCCTTCCTCTGGGACTGCCCAGCCTGTGTCGGGGG
CTTTCAGGGTTTCGTGGGGTTTGCCCGGAAGGCGGCTTTCCTCCCCCTGGTGTGAGGTCGCGCCCGAGGCTTGTACCCGCTAGTGAGGTG
TTTGAGCTGGTCAGCAAGGAGAGGGGGTGGGGTTCCGCGGAAGGTTCTGGAGGGGTCTTGGTAGGTCTGCAGTGAACCGTCCTGAGGATG
GAGTGGGGTCCCATGGTGCAGGTCTCTGAGCAAGGCGGAGGTGTGGAGGAGAGGCCGGCTTGGGGTGGGGCCTCGCGCCCTAGTGCCGGC
CGGCCTCAGCCCGGCTCTGCCTGGTGCTCCCTGCAGTGCCTTCTCCATGGCCCCGCCCTCCCCGCGTGTGCGCCAGGCTTGGGGTCCCCG
GGAGAGCAGAGCTTGCGCCTCGGGCATAGGGACGTGGGGTGCAGGCGCCAACATCAGTGGCAGCAGCCAGGGCCGTGGTCCAGTCCCACT
CGGGGATGGAGTGGGCCGGCGGCCAAACCAGTCACTCGGGGAGGAATGCGGAGGAGCGCTCATTCCATTCTATTTAATTGCAGTGTACAA

>71107_71107_1_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000361574_TMEM259_chr19_1014472_ENST00000333175_length(amino acids)=332AA_BP=1
MFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNS
SIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLL
DEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAI

--------------------------------------------------------------
>71107_71107_2_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000361574_TMEM259_chr19_1014472_ENST00000356663_length(transcript)=2485nt_BP=145nt
CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA
ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTGCCCTGTTTGTGCTCTTCGTCCTGGCCTACATCCA
CATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCGCGTGAGGGCATCCTGCGTGTGGAAGTGCGGCA
CAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGCTTCCCGGGCCTGGCCGTGGAACCAGGCAGCAA
CCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGCTCCATCAAGTTTGAGCTGGACATCGAGCCCAA
GGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTCCCCGAGACGCCCACCAAAGTGTGGCCGCAGGA
CGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACCCGCCAGCGCCTGAGCATCCCCGTCATGGTGGT
CACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTGGATGAGTTCCTGGGCTACGATGACATCCTCAT
GTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTGGTGTCGGGCGAGCACTACCGCTTTGTGAGCAT
GTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTGAGCGTGTCCATGCTGCTGCGGTACTCACACCA
CCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATCGCCTTCCCCGCAGCGCCCCTGCTGACCGTCAT
CCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACCGCCTTCTACATCATCCTCATCGTGTGGCTCGC
GGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGGTTCTTCTATCTCTACCACTTCGCCTTCTATGC
CTATCACTACCGCTTCAATGGGCAGTATAGCAGCCTGGCCCTGGTCACCTCCTGGCTCTTCATCCAGCATTCCATGATCTACTTCTTCCA
CCACTACGAGCTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAGGCGCCGCCACTGGGCCCCGGGACCCCCACGGC
GCTGCCCGATGACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCCGGCCAGCCCCCCGCCCTGGGCCCCGTCTCGCC
TGGGGCCAGCGGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCGGCAGCCTCAGTGGCAGCAGCTGCCGGTGGTGA
CCTGGGTTGGATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGCCTGAGCGCCTCCCTCCTGGAGCGGCGTCCAGC
CAGCCCGCTGGGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCGAGTGACTCCGCAGCTTCTGACACAACTCCCCT
GGGGGCTGCGGTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCGGAGGTGGGGTCCTGAGCCGCACAGCTGAGCCG
CCTCTGACCCCTGCTGGCTGGGCCTGACCTTCCCGAGCCCGTGGGGGTGGGGGAGGCCAGCCACCTCCTTCCTCTGGGACTGCCCAGCCT
GTGTCGGGGGCTTTCAGGGTTTCGTGGGGTTTGCCCGGAAGGCGGCTTTCCTCCCCCTGGTGTGAGGTCGCGCCCGAGGCTTGTACCCGC
TAGTGAGGTGTTTGAGCTGGTCAGCAAGGAGAGGGGGTGGGGTTCCGCGGAAGGTTCTGGAGGGGTCTTGGTAGGTCTGCAGTGAACCGT
CCTGAGGATGGAGTGGGGTCCCATGGTGCAGGTCTCTGAGCAAGGCGGAGGTGTGGAGGAGAGGCCGGCTTGGGGTGGGGCCTCGCGCCC
TAGTGCCGGCCGGCCTCAGCCCGGCTCTGCCTGGTGCTCCCTGCAGTGCCTTCTCCATGGCCCCGCCCTCCCCGCGTGTGCGCCAGGCTT
GGGGTCCCCGGGAGAGCAGAGCTTGCGCCTCGGGCATAGGGACGTGGGGTGCAGGCGCCAACATCAGTGGCAGCAGCCAGGGCCGTGGTC
CAGTCCCACTCGGGGATGGAGTGGGCCGGCGGCCAAACCAGTCACTCGGGGAGGAATGCGGAGGAGCGCTCATTCCATTCTATTTAATTG

>71107_71107_2_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000361574_TMEM259_chr19_1014472_ENST00000356663_length(amino acids)=544AA_BP=1
MFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNS
SIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLL
DEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAI
AFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWL
FIQHSMIYFFHHYELPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSSLVAA
AASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLERRPASPLGPAGGLPHAPQDSVPPSDSAASDTTPLGAAVGGPSPASMAPTEAPS

--------------------------------------------------------------
>71107_71107_3_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000587975_TMEM259_chr19_1014472_ENST00000333175_length(transcript)=2391nt_BP=154nt
GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG
CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTGCCCTGTTTGTGCTCTTCGTCCTGGC
CTACATCCACATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCGCGTGAGGGCATCCTGCGTGTGGA
AGTGCGGCACAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGCTTCCCGGGCCTGGCCGTGGAACC
AGGCAGCAACCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGCTCCATCAAGTTTGAGCTGGACAT
CGAGCCCAAGGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTCCCCGAGACGCCCACCAAAGTGTG
GCCGCAGGACGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACCCGCCAGCGCCTGAGCATCCCCGT
CATGGTGGTCACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTGGATGAGTTCCTGGGCTACGATGA
CATCCTCATGTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTGGTGTCGGGCGAGCACTACCGCTT
TGTGAGCATGTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTGAGCGTGTCCATGCTGCTGCGGTA
CTCACACCACCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATCGCCTTCCCCGCAGCGCCCCTGCT
GACCGTCATCCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACCGCCTTCTACATCATCCTCATCGT
GTGGCTCGCGGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGCATTCCATGATCTACTTCTTCCAC
CACTACGAGCTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAGGCGCCGCCACTGGGCCCCGGGACCCCCACGGCG
CTGCCCGATGACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCCGGCCAGCCCCCCGCCCTGGGCCCCGTCTCGCCT
GGGGCCAGCGGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCGGCAGCCTCAGTGGCAGCAGCTGCCGGTGGTGAC
CTGGGTTGGATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGCCTGAGCGCCTCCCTCCTGGAGCGGCGTCCAGCC
AGCCCGCTGGGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCGAGTGACTCCGCAGCTTCTGACACAACTCCCCTG
GGGGCTGCGGTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCGGAGGTGGGGTCCTGAGCCGCACAGCTGAGCCGC
CTCTGACCCCTGCTGGCTGGGCCTGACCTTCCCGAGCCCGTGGGGGTGGGGGAGGCCAGCCACCTCCTTCCTCTGGGACTGCCCAGCCTG
TGTCGGGGGCTTTCAGGGTTTCGTGGGGTTTGCCCGGAAGGCGGCTTTCCTCCCCCTGGTGTGAGGTCGCGCCCGAGGCTTGTACCCGCT
AGTGAGGTGTTTGAGCTGGTCAGCAAGGAGAGGGGGTGGGGTTCCGCGGAAGGTTCTGGAGGGGTCTTGGTAGGTCTGCAGTGAACCGTC
CTGAGGATGGAGTGGGGTCCCATGGTGCAGGTCTCTGAGCAAGGCGGAGGTGTGGAGGAGAGGCCGGCTTGGGGTGGGGCCTCGCGCCCT
AGTGCCGGCCGGCCTCAGCCCGGCTCTGCCTGGTGCTCCCTGCAGTGCCTTCTCCATGGCCCCGCCCTCCCCGCGTGTGCGCCAGGCTTG
GGGTCCCCGGGAGAGCAGAGCTTGCGCCTCGGGCATAGGGACGTGGGGTGCAGGCGCCAACATCAGTGGCAGCAGCCAGGGCCGTGGTCC
AGTCCCACTCGGGGATGGAGTGGGCCGGCGGCCAAACCAGTCACTCGGGGAGGAATGCGGAGGAGCGCTCATTCCATTCTATTTAATTGC

>71107_71107_3_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000587975_TMEM259_chr19_1014472_ENST00000333175_length(amino acids)=332AA_BP=1
MFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNS
SIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLL
DEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAI

--------------------------------------------------------------
>71107_71107_4_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000587975_TMEM259_chr19_1014472_ENST00000356663_length(transcript)=2494nt_BP=154nt
GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG
CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTGCCCTGTTTGTGCTCTTCGTCCTGGC
CTACATCCACATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCGCGTGAGGGCATCCTGCGTGTGGA
AGTGCGGCACAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGCTTCCCGGGCCTGGCCGTGGAACC
AGGCAGCAACCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGCTCCATCAAGTTTGAGCTGGACAT
CGAGCCCAAGGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTCCCCGAGACGCCCACCAAAGTGTG
GCCGCAGGACGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACCCGCCAGCGCCTGAGCATCCCCGT
CATGGTGGTCACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTGGATGAGTTCCTGGGCTACGATGA
CATCCTCATGTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTGGTGTCGGGCGAGCACTACCGCTT
TGTGAGCATGTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTGAGCGTGTCCATGCTGCTGCGGTA
CTCACACCACCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATCGCCTTCCCCGCAGCGCCCCTGCT
GACCGTCATCCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACCGCCTTCTACATCATCCTCATCGT
GTGGCTCGCGGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGGTTCTTCTATCTCTACCACTTCGC
CTTCTATGCCTATCACTACCGCTTCAATGGGCAGTATAGCAGCCTGGCCCTGGTCACCTCCTGGCTCTTCATCCAGCATTCCATGATCTA
CTTCTTCCACCACTACGAGCTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAGGCGCCGCCACTGGGCCCCGGGAC
CCCCACGGCGCTGCCCGATGACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCCGGCCAGCCCCCCGCCCTGGGCCC
CGTCTCGCCTGGGGCCAGCGGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCGGCAGCCTCAGTGGCAGCAGCTGC
CGGTGGTGACCTGGGTTGGATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGCCTGAGCGCCTCCCTCCTGGAGCG
GCGTCCAGCCAGCCCGCTGGGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCGAGTGACTCCGCAGCTTCTGACAC
AACTCCCCTGGGGGCTGCGGTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCGGAGGTGGGGTCCTGAGCCGCACA
GCTGAGCCGCCTCTGACCCCTGCTGGCTGGGCCTGACCTTCCCGAGCCCGTGGGGGTGGGGGAGGCCAGCCACCTCCTTCCTCTGGGACT
GCCCAGCCTGTGTCGGGGGCTTTCAGGGTTTCGTGGGGTTTGCCCGGAAGGCGGCTTTCCTCCCCCTGGTGTGAGGTCGCGCCCGAGGCT
TGTACCCGCTAGTGAGGTGTTTGAGCTGGTCAGCAAGGAGAGGGGGTGGGGTTCCGCGGAAGGTTCTGGAGGGGTCTTGGTAGGTCTGCA
GTGAACCGTCCTGAGGATGGAGTGGGGTCCCATGGTGCAGGTCTCTGAGCAAGGCGGAGGTGTGGAGGAGAGGCCGGCTTGGGGTGGGGC
CTCGCGCCCTAGTGCCGGCCGGCCTCAGCCCGGCTCTGCCTGGTGCTCCCTGCAGTGCCTTCTCCATGGCCCCGCCCTCCCCGCGTGTGC
GCCAGGCTTGGGGTCCCCGGGAGAGCAGAGCTTGCGCCTCGGGCATAGGGACGTGGGGTGCAGGCGCCAACATCAGTGGCAGCAGCCAGG
GCCGTGGTCCAGTCCCACTCGGGGATGGAGTGGGCCGGCGGCCAAACCAGTCACTCGGGGAGGAATGCGGAGGAGCGCTCATTCCATTCT

>71107_71107_4_R3HDM4-TMEM259_R3HDM4_chr19_913087_ENST00000587975_TMEM259_chr19_1014472_ENST00000356663_length(amino acids)=544AA_BP=1
MFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNS
SIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLL
DEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAI
AFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWL
FIQHSMIYFFHHYELPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSSLVAA
AASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLERRPASPLGPAGGLPHAPQDSVPPSDSAASDTTPLGAAVGGPSPASMAPTEAPS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for R3HDM4-TMEM259

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for R3HDM4-TMEM259

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for R3HDM4-TMEM259

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source