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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB11B-HAUS3 (FusionGDB2 ID:71126)

Fusion Gene Summary for RAB11B-HAUS3

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB11B-HAUS3
Fusion gene ID: 71126
HgeneTgene
Gene symbol

RAB11B

HAUS3

Gene ID

339122

79441

Gene nameRAB43, member RAS oncogene familyHAUS augmin like complex subunit 3
SynonymsRAB11B|RAB41C4orf15|IT1|dgt3
Cytomap

3q21.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-43ras-related protein Rab-41HAUS augmin-like complex subunit 3
Modification date2020031320200313
UniProtAcc.

Q68CZ6

Ensembl transtripts involved in fusion geneENST00000328024, ENST00000601897, 
ENST00000594216, 		ENST00000243706, 
ENST00000443786, ENST00000506763, 
Fusion gene scores* DoF score10 X 6 X 6=3602 X 3 X 2=12
# samples 102
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RAB11B [Title/Abstract] AND HAUS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB11B(8467449)-HAUS3(2240770), # samples:2
Anticipated loss of major functional domain due to fusion event.RAB11B-HAUS3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RAB11B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HAUS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1348-01ARAB11Bchr19

8467449

+HAUS3chr4

2240770

-


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Fusion Gene ORF analysis for RAB11B-HAUS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000328024ENST00000243706RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
Frame-shiftENST00000328024ENST00000443786RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
Frame-shiftENST00000328024ENST00000506763RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
Frame-shiftENST00000601897ENST00000243706RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
Frame-shiftENST00000601897ENST00000443786RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
Frame-shiftENST00000601897ENST00000506763RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
In-frameENST00000594216ENST00000243706RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
In-frameENST00000594216ENST00000443786RAB11Bchr19

8467449

+HAUS3chr4

2240770

-
In-frameENST00000594216ENST00000506763RAB11Bchr19

8467449

+HAUS3chr4

2240770

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000594216RAB11Bchr198467449+ENST00000506763HAUS3chr42240770-23218137771373198
ENST00000594216RAB11Bchr198467449+ENST00000243706HAUS3chr42240770-52948137771715312
ENST00000594216RAB11Bchr198467449+ENST00000443786HAUS3chr42240770-18028137771715312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000594216ENST00000506763RAB11Bchr198467449+HAUS3chr42240770-0.005024870.9949751
ENST00000594216ENST00000243706RAB11Bchr198467449+HAUS3chr42240770-0.0005430880.99945694
ENST00000594216ENST00000443786RAB11Bchr198467449+HAUS3chr42240770-0.0018931120.99810684

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Fusion Genomic Features for RAB11B-HAUS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAB11B-HAUS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:8467449/chr4:2240770)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HAUS3

Q68CZ6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11Bchr19:8467449chr4:2240770ENST00000328024+4540_48170219.0MotifEffector region
HgeneRAB11Bchr19:8467449chr4:2240770ENST00000328024+45124_127170219.0Nucleotide bindingGTP
HgeneRAB11Bchr19:8467449chr4:2240770ENST00000328024+45154_156170219.0Nucleotide bindingGTP
HgeneRAB11Bchr19:8467449chr4:2240770ENST00000328024+4518_26170219.0Nucleotide bindingGTP
HgeneRAB11Bchr19:8467449chr4:2240770ENST00000328024+4566_70170219.0Nucleotide bindingGTP
TgeneHAUS3chr19:8467449chr4:2240770ENST0000024370615305_336303604.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS3chr19:8467449chr4:2240770ENST0000024370615389_426303604.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS3chr19:8467449chr4:2240770ENST0000024370615458_495303604.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS3chr19:8467449chr4:2240770ENST0000044378626305_336303604.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS3chr19:8467449chr4:2240770ENST0000044378626389_426303604.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS3chr19:8467449chr4:2240770ENST0000044378626458_495303604.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHAUS3chr19:8467449chr4:2240770ENST000002437061593_177303604.0Coiled coilOntology_term=ECO:0000255
TgeneHAUS3chr19:8467449chr4:2240770ENST000004437862693_177303604.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for RAB11B-HAUS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71126_71126_1_RAB11B-HAUS3_RAB11B_chr19_8467449_ENST00000594216_HAUS3_chr4_2240770_ENST00000243706_length(transcript)=5294nt_BP=813nt
GATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGGTGCTCATCGGGGACTCAGGCGTG
GGCAAGAGCAACCTGCTGTCGCGCTTCACCCGCAACGAGTTCAACCTGGAGAGCAAGAGCACCATCGGCGTGGAGTTCGCCACCCGCAGC
ATCCAGGTGGACGGCAAGACCATCAAGGCGCAGATCTGGGACACCGCTGGCCAGGAGCGCTACCGCGCCATCACCTCCGCGTACTACCGT
GGTGCAGTGGGCGCCCTGCTGGTGTACGACATCGCCAAGCACCTGACCTATGAGAACGTGGAGCGCTGGCTGAAGGAGCTGCGGGACCAC
GCAGACAGCAACATCGTCATCATGCTGGTGGGCAACAAGAGTGACCTGCGCCACCTGCGGGCTGTGCCCACTGACGAGGCCCGCGCCTTC
GCAGGTGGCCGGGGACCAGATGGGTGTGGGTAGGGCACCAGCCAGGCAGGGTGGAACACGGCCTCTGAACCTTCGCTTGTTTTGTTCGTT
TGCTTGTTTTTTTCTTTTTTTTGTCGGGGCAGGATGGATTTTTGCTCTTTGCCCAGGCTGGAGTGTGGTGGCTCGATCTCAGCTTACTGC
AACCTCCGCCTTCCAGGTTCAGGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACACCCGCTAATTT
TTGTAATTTTTAGTAGAGACAGGATTTCACAATGTTGTCCAGGTTGATCTCGAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCC
CAAGCTGTGGACAAAGAAAATTTGGATGCTAAAATTTCTAGCTTGACCAGTGAGATTATGAAACTTGAAAAAGAGGTCACTCAAATAAAA
GACAGAAGTTTACCTGCTGTGGTAAGAGAGAATGCCCAGTTATTGAATATGCCAGTGGTAAAGGGAGATTTTGATCTGCAGATTGCTAAA
CAAGATTATTATACAGCAAGACAAGAGTTAGTTTTAAATCAATTAATAAAACAAAAGGCATCATTTGAACTTCTACAGTTATCATATGAA
ATTGAATTAAGAAAGCATCGGGACATATATCGTCAACTTGAAAATTTGGTTCAAGAACTTAGTCAAAGTAACATGATGCTCTACAAGCAA
TTAGAAATGTTAACAGATCCATCAGTTTCTCAACAGATAAATCCAAGGAATACCATTGATACTAAGGATTATTCTACTCATAGGCTTTAC
CAAGTTTTGGAGGGAGAGAATAAGAAAAAAGAATTGTTTCTAACTCATGGAAACCTTGAGGAAGTGGCTGAGAAATTGAAACAGAATATT
TCTTTAGTACAAGATCAGTTGGCAGTATCTGCTCAAGAACATTCTTTCTTTCTGTCCAAACGGAATAAGGATGTGGACATGCTTTGTGAT
ACTTTGTATCAAGGAGGAAATCAGCTTTTGCTTAGTGATCAGGAGTTAACAGAGCAGTTTCATAAAGTTGAATCTCAACTGAATAAGCTA
AATCATCTCCTCACTGATATTCTTGCTGATGTGAAGACAAAAAGAAAAACTTTGGCAAATAATAAATTACATCAAATGGAAAGAGAATTC
TATGTATATTTTTTAAAAGATGAAGATTATCTGAAAGATATTGTGGAGAATTTAGAAACTCAATCAAAGATTAAGGCTGTTAGTCTTGAA
GATTGAAAATTACTGAAAACTGAATCTTTATTACGTGTCCTCTTTTATTTATTAGAAGACTGTGTATAATAAACACTACTAAATTTTTAA
AATTTGAGGTCAATGGAACATTTAATTTGATGAATTGAACTATTATATTAATTTGTCTTTTTTCTCATGTAGTACATTCAGAATACCAGT
GCTTTTTATGACTTGAGCATGTGTTTAGTGGTACTTAGTCCTGGTAATTTTTTACTTACAGGGAAAAAGCATTATTACATAATGCAAATA
TTTTTTAATATAGTTATCTCTCTCCTTTTTAGAAATAGAAATTTTCTGCCGTTAAATTTTTTTTTGAGATAGAGTCTCACTCTGTCTCCA
GGCTGGAATGCAGTGGCACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTG
GGACTACAGGCGCACACCGCCACACCCAGCTAATTTTTTTGTATTTTAGTAGAAAAGGGGTTTCACCATGTTGGCCAGGATGGTCTCAAT
CTCTTGACCTCTTGATCCCCTCTCCCGGCCTCCCAAAGTGCCGGAATTACAGGCATGAGCCACCACGCTCAGCCGCTATTAAATATTTTA
AAATGTGTAGAACTTCTAGTCAGCATTTTTAAATCTGTAGACCTTAATATGTGAAATAGCCAAGTCCCCTCATGTTTGACTGTCAAATAA
AATTCTGCTGCTCAAATTGTATTCCTCCATAATTCCCTGCTATAGACCTTTAGGCTGTTTTAATGTCCCTACTTGTACCACAGAGTATTA
GGACTTCCTTGGCCTGCCTGCATTCATTTTAGAGTCTGAATTCTGGGGACTCAAAAGTTTCTACAAGACAGCTGAGCAGTGCTTTGACTT
TAATGTGACTTACACATCATAAATGACTTTCAAATGAAATTTGAATTTCAAAATTCTGTAAAAGTGGTTGCTCAAAAGATGTATGATACT
ATTTTAATCAGTTTAAGAGCAAAAATGTCTAATTGTATTTAACAATGGTATTTGGGCAGCCAGAAAATATTTTAAGCGTTGCTCTAAAAT
AATTTGAAGTAGCTCATCTGTTATTACATCAGATGCTTCTTGAGTGCCCAATTTATACATGGCCTGTGGTAAATACCATGTGAGCTTTGT
AGGAATACCTTTAAGAATATTCCTCACCTGTTCGTAATATGGAATGCCAATCTAAAAACTACATGTTTTGGGTGGTCTTTATGGAATTTT
TTAGCTATAACCATCAGAAAACAGGCATACCTAGATGACAGATGAACCTTCTTGATTTTTGAAACCCATTGAACAAAAATATTTTGCCAA
TTATTGTGTTTATGTTATTTAAAATTTTATGTAAACCTTAATTTTGTAGCAGTAAATTTTGTTTAAGATTTTGCTATCAGCTCCCTATCA
CCTGAGCAACTTTTTTTTTGTTGTATATGTTTTTTTCTATTCTATTTCGGAATAGAGAATTTACTTAAAATTTTTATTTTCTCCAAAAAT
GTGGAAAATATGTCACCTGGTTTCCTGGTTTATGGTAGCATATTCTGTTTAAATTAGTGTCACATATTTAGATGTGTGGCCAGACGCTTG
ATTTATTAGTTAATTTTTGAGACAGAGTCTAACTGTGTCACTCAGGCTGGAGTTCAGTGGAATGATCTCGGCTCACTGCAACCTCCGCCT
CCCAGGTTCAAGTGATTCTCCTGCTTCAGCCTCCTGAGTAGATGGGATTGTAGGCGTGCACCACTGCACCTGGCTAATTTTTGTATTTTC
AGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCTACCCGCCTTGGCCTTCCATAGTGCTGG
CATTACAGGTGTAAGCCACCATGCCCCTGCCCAGATGCTTGATTTATACTGTCCCCACCCAAACCTTGACTTGCTCAGCCCAGGGGGCCA
GCAGGGCAGATCAAGGCACGGATGGTAGTTGTGTGTCTGCCGTAATTACCCAAGTTACTTATAATCGTTGTGTTACTAGGTAGGTTTATT
TGAAGATTTATTTATTTATTTATTTATTTTTTATTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCT
CAGCTCACTGCAACCTCTGCCTTCTGGGTTCACGTGATTCTCCTGCCTCAGGCCTCCCGAGTAGCTGGGATTACAGGTGCCACCATGCCT
GGTTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTGGCCAGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCC
TCAGTCTACCAAAGTGCAGGGATCACAGGCATGAGCTTCCGCGCTCAGCCTATTTGAAGATTTAATAACATTTTTCAAACCTCAGGATGT
ATTTGAGTAGATTGCTTCTAAATTGGTCACCTAGAAAATAAGTTATCTATTTACTATGATACCTGGATTAAGCCTCTAGCTATTTTGCTT
TTTTCTTTCTATCTATATTATTGGATGATTGATGCCTATTTTCTGTGGTTATGAATATAGACATTTTAAATGAAAGTTGGTATATAAATT
TTTGAAAATAATTGTATTTCCTGTTTTATAGTCTTAGGATTAATATATGGGATTTATCTTATGTTAATCTTACATTTAGGATTTTGTGAA
AATGGAAAATTATGAGGCATTGGTAGGCTTTGATCTCTGTAATACACCGCTCTCCAGTGTTGCTCAGAAGATTATGTCTGCTATGCATTC
AGGTGATTTAGTGGATTCTAAGACTTGGGGAAAGAGTACAGAGAGTAAGTAATTTTTATGAACCTTTCTTTCTCTTGATACTTTGAATGT
TAATTGTTCTAAAGACTAAGAATTGAAAATGGAATGCATGTAGACAGATGAAGCCCAGCTCCCGCCCCTTTTACACTCATTCAGTGCAGA
CTGAGCTTCTGCTTGCTAACTTTCGTGTTCCCTTAACCTTCATTGCTTTAAAAATGTAACACTCTCTTCCTTATTCCAGGTATTTCTGTC
AAACATTCCCTTAGAATCTGGATCAGGTATTTTAGTATTTTCAAAAGAGATGCTTTAATCTTGGTTCTCAGGTCATCAAACCTGTACATA
GTATTTGCTATTTTGTGTGGTGAACAAGAGATATGTTTTTGACAATATGTGTATTGTGCTGCTATAGAAATGTAAACTCTTAGGTGGCAA
GGATTATTGGATCAGTGTATATGGATTTATGATGTGGTATAATAGTAAAAGCAGTGGGGCCGGGTGCGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCGAGGTCGGCGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTAAAACACTGTCTCTACTAAAAAT
ACAAAAAATTAGCTGGGAGTGGTGGTAGGCGCCTGTAGTCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCGG

>71126_71126_1_RAB11B-HAUS3_RAB11B_chr19_8467449_ENST00000594216_HAUS3_chr4_2240770_ENST00000243706_length(amino acids)=312AA_BP=2
MGSSDPPASASQAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQK
ASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNL
EEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLA

--------------------------------------------------------------
>71126_71126_2_RAB11B-HAUS3_RAB11B_chr19_8467449_ENST00000594216_HAUS3_chr4_2240770_ENST00000443786_length(transcript)=1802nt_BP=813nt
GATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGGTGCTCATCGGGGACTCAGGCGTG
GGCAAGAGCAACCTGCTGTCGCGCTTCACCCGCAACGAGTTCAACCTGGAGAGCAAGAGCACCATCGGCGTGGAGTTCGCCACCCGCAGC
ATCCAGGTGGACGGCAAGACCATCAAGGCGCAGATCTGGGACACCGCTGGCCAGGAGCGCTACCGCGCCATCACCTCCGCGTACTACCGT
GGTGCAGTGGGCGCCCTGCTGGTGTACGACATCGCCAAGCACCTGACCTATGAGAACGTGGAGCGCTGGCTGAAGGAGCTGCGGGACCAC
GCAGACAGCAACATCGTCATCATGCTGGTGGGCAACAAGAGTGACCTGCGCCACCTGCGGGCTGTGCCCACTGACGAGGCCCGCGCCTTC
GCAGGTGGCCGGGGACCAGATGGGTGTGGGTAGGGCACCAGCCAGGCAGGGTGGAACACGGCCTCTGAACCTTCGCTTGTTTTGTTCGTT
TGCTTGTTTTTTTCTTTTTTTTGTCGGGGCAGGATGGATTTTTGCTCTTTGCCCAGGCTGGAGTGTGGTGGCTCGATCTCAGCTTACTGC
AACCTCCGCCTTCCAGGTTCAGGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACACCCGCTAATTT
TTGTAATTTTTAGTAGAGACAGGATTTCACAATGTTGTCCAGGTTGATCTCGAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCC
CAAGCTGTGGACAAAGAAAATTTGGATGCTAAAATTTCTAGCTTGACCAGTGAGATTATGAAACTTGAAAAAGAGGTCACTCAAATAAAA
GACAGAAGTTTACCTGCTGTGGTAAGAGAGAATGCCCAGTTATTGAATATGCCAGTGGTAAAGGGAGATTTTGATCTGCAGATTGCTAAA
CAAGATTATTATACAGCAAGACAAGAGTTAGTTTTAAATCAATTAATAAAACAAAAGGCATCATTTGAACTTCTACAGTTATCATATGAA
ATTGAATTAAGAAAGCATCGGGACATATATCGTCAACTTGAAAATTTGGTTCAAGAACTTAGTCAAAGTAACATGATGCTCTACAAGCAA
TTAGAAATGTTAACAGATCCATCAGTTTCTCAACAGATAAATCCAAGGAATACCATTGATACTAAGGATTATTCTACTCATAGGCTTTAC
CAAGTTTTGGAGGGAGAGAATAAGAAAAAAGAATTGTTTCTAACTCATGGAAACCTTGAGGAAGTGGCTGAGAAATTGAAACAGAATATT
TCTTTAGTACAAGATCAGTTGGCAGTATCTGCTCAAGAACATTCTTTCTTTCTGTCCAAACGGAATAAGGATGTGGACATGCTTTGTGAT
ACTTTGTATCAAGGAGGAAATCAGCTTTTGCTTAGTGATCAGGAGTTAACAGAGCAGTTTCATAAAGTTGAATCTCAACTGAATAAGCTA
AATCATCTCCTCACTGATATTCTTGCTGATGTGAAGACAAAAAGAAAAACTTTGGCAAATAATAAATTACATCAAATGGAAAGAGAATTC
TATGTATATTTTTTAAAAGATGAAGATTATCTGAAAGATATTGTGGAGAATTTAGAAACTCAATCAAAGATTAAGGCTGTTAGTCTTGAA
GATTGAAAATTACTGAAAACTGAATCTTTATTACGTGTCCTCTTTTATTTATTAGAAGACTGTGTATAATAAACACTACTAAATTTTTAA

>71126_71126_2_RAB11B-HAUS3_RAB11B_chr19_8467449_ENST00000594216_HAUS3_chr4_2240770_ENST00000443786_length(amino acids)=312AA_BP=2
MGSSDPPASASQAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQK
ASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNL
EEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLA

--------------------------------------------------------------
>71126_71126_3_RAB11B-HAUS3_RAB11B_chr19_8467449_ENST00000594216_HAUS3_chr4_2240770_ENST00000506763_length(transcript)=2321nt_BP=813nt
GATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGGTGCTCATCGGGGACTCAGGCGTG
GGCAAGAGCAACCTGCTGTCGCGCTTCACCCGCAACGAGTTCAACCTGGAGAGCAAGAGCACCATCGGCGTGGAGTTCGCCACCCGCAGC
ATCCAGGTGGACGGCAAGACCATCAAGGCGCAGATCTGGGACACCGCTGGCCAGGAGCGCTACCGCGCCATCACCTCCGCGTACTACCGT
GGTGCAGTGGGCGCCCTGCTGGTGTACGACATCGCCAAGCACCTGACCTATGAGAACGTGGAGCGCTGGCTGAAGGAGCTGCGGGACCAC
GCAGACAGCAACATCGTCATCATGCTGGTGGGCAACAAGAGTGACCTGCGCCACCTGCGGGCTGTGCCCACTGACGAGGCCCGCGCCTTC
GCAGGTGGCCGGGGACCAGATGGGTGTGGGTAGGGCACCAGCCAGGCAGGGTGGAACACGGCCTCTGAACCTTCGCTTGTTTTGTTCGTT
TGCTTGTTTTTTTCTTTTTTTTGTCGGGGCAGGATGGATTTTTGCTCTTTGCCCAGGCTGGAGTGTGGTGGCTCGATCTCAGCTTACTGC
AACCTCCGCCTTCCAGGTTCAGGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACACCCGCTAATTT
TTGTAATTTTTAGTAGAGACAGGATTTCACAATGTTGTCCAGGTTGATCTCGAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCC
CAAGCTGTGGACAAAGAAAATTTGGATGCTAAAATTTCTAGCTTGACCAGTGAGATTATGAAACTTGAAAAAGAGGTCACTCAAATAAAA
GACAGAAGTTTACCTGCTGTGGTAAGAGAGAATGCCCAGTTATTGAATATGCCAGTGGTAAAGGGAGATTTTGATCTGCAGATTGCTAAA
CAAGATTATTATACAGCAAGACAAGAGTTAGTTTTAAATCAATTAATAAAACAAAAGGCATCATTTGAACTTCTACAGTTATCATATGAA
ATTGAATTAAGAAAGCATCGGGACATATATCGTCAACTTGAAAATTTGGTTCAAGAACTTAGTCAAAGTAACATGATGCTCTACAAGCAA
TTAGAAATGTTAACAGATCCATCAGTTTCTCAACAGATAAATCCAAGGAATACCATTGATACTAAGGATTATTCTACTCATAGGCTTTAC
CAAGTTTTGGAGGGAGAGAATAAGAAAAAAGAATTGTTTCTAACTCATGGAAACCTTGAGGAAGTGGCTGAGGCAGGAGAATGGCATGAA
CCCAGGAGGCGGGGCTTGCAGTGAGCTGAGGTCTCCAGCGTGGGCGACAGAGTGAGACTCTATCTCAAAAAAAAAAAAAAAAAAAAGTGA
AAGCAGTGATATGCTCACAAATGTCACTGAAATGTTTATAACATCAGGGCTTTTGGTGTTTTTTTGTTTTGTTTTTTGTTGGTGTTTTTT
TTTTTTTTTTGCTACTAGCAAAGCAGTTTTTATTTTAAATTTGCAAGCCTGGGCCAATAGTTTGTGGTTGGTTTCTCTTTCTACAAAATA
AGGTATAAGTGAGTGAGATATAATTGAGTAATGAAATTGCATTGAAATAATTGAGAGTATTGCCGAATATTAGCACAAAAGCTCTTATAA
ACACATCTTGATTAAGATACATTTGCACTTAACGTTTTGATCCATTCATATTGAGGCATCTGTTGCTTATATACTTTATTATAGTAGAAG
TCACTAATAAACTGGTAAGAATTTTTGAGTGTGAATTACATGCCTAGCAATTGATAGTGTAAGACACTATCATAATCACATTATTCCATA
TTTTTTTGAATAATAGAGGGTGCATACTTGACAGAGGTGGAAATATACTCCCCTTCAAAAACCGGTAAGAATAATGAAATGCCTCTGGCA
GCTATAATATGAGGCTCTGATGAAAAATTTACGACAGTCAGTCCATCTCATATAAGCTCTTATTGTTGTTCTAAAATACATTGTTAATGC
CTGGGACGATCACTTGAGCCCAGGAGTTCGAGTCCAGCCTAGGCAACATAGCAAGATCTCATCTCTGAAAATAAAATACCCCGTTAAAAT
TCTGGCTTTTGTTTGTTAAGGTTATTGAGAAGGTAATAGAAAAAGATATGATACTACTTTTCTCTCTTGGATTTGTAAAAATAGTGGAAT

>71126_71126_3_RAB11B-HAUS3_RAB11B_chr19_8467449_ENST00000594216_HAUS3_chr4_2240770_ENST00000506763_length(amino acids)=198AA_BP=2
MGSSDPPASASQAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQK
ASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNL

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Fusion Gene PPI Analysis for RAB11B-HAUS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB11B-HAUS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB11B-HAUS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource