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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB11B-NCAM2 (FusionGDB2 ID:71127)

Fusion Gene Summary for RAB11B-NCAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB11B-NCAM2
Fusion gene ID: 71127
HgeneTgene
Gene symbol

RAB11B

NCAM2

Gene ID

339122

4685

Gene nameRAB43, member RAS oncogene familyneural cell adhesion molecule 2
SynonymsRAB11B|RAB41NCAM21
Cytomap

3q21.3

21q21.1

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-43ras-related protein Rab-41neural cell adhesion molecule 2N-CAM-2NCAM-2
Modification date2020031320200313
UniProtAcc.

O15394

Ensembl transtripts involved in fusion geneENST00000328024, ENST00000594216, 
ENST00000601897, 		ENST00000486367, 
ENST00000284894, ENST00000400546, 
ENST00000535285, 
Fusion gene scores* DoF score10 X 6 X 6=36019 X 16 X 4=1216
# samples 1019
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1216*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB11B [Title/Abstract] AND NCAM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB11B(8455340)-NCAM2(22696703), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RAB11B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01ARAB11Bchr19

8455340

+NCAM2chr21

22696703

+


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Fusion Gene ORF analysis for RAB11B-NCAM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000328024ENST00000486367RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
5CDS-intronENST00000594216ENST00000486367RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
5UTR-3CDSENST00000601897ENST00000284894RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
5UTR-3CDSENST00000601897ENST00000400546RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
5UTR-3CDSENST00000601897ENST00000535285RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
5UTR-intronENST00000601897ENST00000486367RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
In-frameENST00000328024ENST00000284894RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
In-frameENST00000328024ENST00000400546RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
In-frameENST00000328024ENST00000535285RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
In-frameENST00000594216ENST00000284894RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
In-frameENST00000594216ENST00000400546RAB11Bchr19

8455340

+NCAM2chr21

22696703

+
In-frameENST00000594216ENST00000535285RAB11Bchr19

8455340

+NCAM2chr21

22696703

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328024RAB11Bchr198455340+ENST00000400546NCAM2chr2122696703+7525258712152693
ENST00000328024RAB11Bchr198455340+ENST00000284894NCAM2chr2122696703+2153258712152694
ENST00000328024RAB11Bchr198455340+ENST00000535285NCAM2chr2122696703+90525871838255
ENST00000594216RAB11Bchr198455340+ENST00000400546NCAM2chr2122696703+733164241958644
ENST00000594216RAB11Bchr198455340+ENST00000284894NCAM2chr2122696703+195964241958644
ENST00000594216RAB11Bchr198455340+ENST00000535285NCAM2chr2122696703+7116424644206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328024ENST00000400546RAB11Bchr198455340+NCAM2chr2122696703+0.0003090210.999691
ENST00000328024ENST00000284894RAB11Bchr198455340+NCAM2chr2122696703+0.0027754030.99722457
ENST00000328024ENST00000535285RAB11Bchr198455340+NCAM2chr2122696703+0.0067459420.9932541
ENST00000594216ENST00000400546RAB11Bchr198455340+NCAM2chr2122696703+0.000301550.9996985
ENST00000594216ENST00000284894RAB11Bchr198455340+NCAM2chr2122696703+0.0032334510.99676657
ENST00000594216ENST00000535285RAB11Bchr198455340+NCAM2chr2122696703+0.0044957540.9955043

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Fusion Genomic Features for RAB11B-NCAM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAB11Bchr198455340+NCAM2chr2122696702+2.58E-050.99997425
RAB11Bchr198455340+NCAM2chr2122696702+2.58E-050.99997425

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAB11B-NCAM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:8455340/chr21:22696703)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCAM2

O15394

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418208_297206838.0DomainNote=Ig-like C2-type 3
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418302_396206838.0DomainNote=Ig-like C2-type 4
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418401_491206838.0DomainNote=Ig-like C2-type 5
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418498_591206838.0DomainFibronectin type-III 1
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418593_688206838.0DomainFibronectin type-III 2
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418719_837206838.0Topological domainCytoplasmic
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418698_718206838.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11Bchr19:8455340chr21:22696703ENST00000328024+1540_4813219.0MotifEffector region
HgeneRAB11Bchr19:8455340chr21:22696703ENST00000328024+15124_12713219.0Nucleotide bindingGTP
HgeneRAB11Bchr19:8455340chr21:22696703ENST00000328024+15154_15613219.0Nucleotide bindingGTP
HgeneRAB11Bchr19:8455340chr21:22696703ENST00000328024+1518_2613219.0Nucleotide bindingGTP
HgeneRAB11Bchr19:8455340chr21:22696703ENST00000328024+1566_7013219.0Nucleotide bindingGTP
TgeneNCAM2chr19:8455340chr21:22696703ENST00000400546418113_202206838.0DomainNote=Ig-like C2-type 2
TgeneNCAM2chr19:8455340chr21:22696703ENST0000040054641821_108206838.0DomainNote=Ig-like C2-type 1
TgeneNCAM2chr19:8455340chr21:22696703ENST0000040054641820_697206838.0Topological domainExtracellular


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Fusion Gene Sequence for RAB11B-NCAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71127_71127_1_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000328024_NCAM2_chr21_22696703_ENST00000284894_length(transcript)=2153nt_BP=258nt
TTTCTCCAGGACACCGAGGGCGAGGAGGGTGGTACCAAGCGGCGCCCACCCTCAGAGCACTACTTCCATCTCTGATTGGCTTCGCTGGGT
GCCCGTCGCTACTCCACTCGCCGCTGATAGGCCATTCAACCGCCGCTCTGCGCGGCGCCGGCTCCGCCCCCGTCGGGTGTTTGTGGTGGG
GCTGCGGAGTCGCCGATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGCCGCCAGCAA
TCTCAATGCCTCAGAAATCTTTTAATGCCACAGCAGAGAGAGGAGAAGAAATGACATTTTCCTGCAGGGCCTCAGGCTCTCCAGAACCCG
CCATCTCCTGGTTCAGGAATGGCAAGCTCATTGAAGAAAATGAGAAGTACATATTGAAAGGGAGCAATACAGAACTCACTGTCAGGAACA
TAATCAATAGTGATGGTGGTCCTTATGTCTGCAGGGCCACAAATAAGGCAGGAGAAGATGAAAAGCAAGCTTTCCTCCAAGTCTTTGTAC
AGCCTCACATAATACAGCTTAAAAATGAAACTACATATGAGAATGGTCAAGTCACACTCGTATGTGATGCGGAAGGGGAGCCTATTCCAG
AAATCACTTGGAAAAGAGCTGTGGATGGCTTCACGTTCACTGAAGGCGATAAGAGCCTGGACGGCCGTATCGAAGTCAAAGGGCAGCATG
GAAGCTCATCACTGCATATTAAAGATGTGAAGTTGTCAGATTCAGGGAGATATGACTGTGAAGCTGCAAGCAGAATTGGAGGGCATCAAA
AGAGCATGTACCTTGATATTGAATATGCCCCCAAGTTTATATCAAACCAAACAATTTATTACTCTTGGGAAGGAAATCCTATCAATATAA
GTTGTGATGTGAAATCGAATCCACCAGCATCAATTCACTGGAGAAGAGATAAATTAGTCTTACCTGCTAAAAACACGACCAATTTAAAGA
CTTATAGTACAGGAAGAAAGATGATATTAGAGATTGCACCTACATCTGACAATGACTTTGGACGCTATAATTGCACAGCCACTAATCATA
TAGGAACAAGATTTCAAGAATATATTCTTGCTTTGGCTGACGTGCCATCCAGTCCCTATGGAGTGAAGATCATAGAGCTGTCGCAGACCA
CGGCCAAGGTTTCCTTCAACAAACCGGACTCCCATGGAGGTGTACCTATTCATCACTATCAGGTGGATGTCAAAGAAGTAGCGTCAGAAA
TCTGGAAAATTGTACGCTCCCATGGAGTTCAAACAATGGTTGTTTTGAACAACCTGGAACCAAATACAACTTATGAAATCAGGGTTGCAG
CTGTAAATGGAAAGGGACAAGGAGACTACAGTAAAATAGAAATCTTCCAAACATTACCAGTTCGTGAACCAAGTCCTCCATCCATACATG
GACAGCCAAGCAGTGGAAAGAGCTTTAAACTCAGCATCACCAAACAGGACGATGGAGGGGCCCCTATTTTGGAATACATTGTGAAATATA
GAAGTAAAGATAAGGAAGACCAATGGCTAGAGAAAAAAGTGCAAGGAAATAAAGACCACATCATTTTGGAGCATCTCCAGTGGACCATGG
GGTATGAAGTTCAGATTACAGCTGCCAATAGATTGGGATATTCTGAACCGACAGTTTATGAATTCAGCATGCCACCAAAGCCCAACATTA
TTAAAGACACGCTGTTTAATGGTCTTGGGCTTGGAGCAGTAATTGGCCTGGGAGTTGCTGCACTGCTGCTAATTCTTGTGGTAACAGACG
TCAGCTGCTTCTTTATTCGGCAATGTGGGTTGCTGATGTGCATCACTAGGAGAATGTGTGGAAAGAAAAGTGGCTCCAGTGGCAAAAGTA
AAGAACTCGAAGAAGGAAAAGCTGCATACCTGAAAGATGGATCAAAAGAACCAATAGTGGAGATGAGAACAGAGGATGAAAGAGTTACTA
ATCACGAAGATGGGAGCCCAGTAAATGAGCCAAATGAAACCACACCACTGACAGAACCTGAAAAATTGCCTTTAAAGGAAGAAGATGGGA

>71127_71127_1_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000328024_NCAM2_chr21_22696703_ENST00000284894_length(amino acids)=694AA_BP=62
MIGFAGCPSLLHSPLIGHSTAALRGAGSAPVGCLWWGCGVADPAGSARTMGTRDDEYDYLFKVPPAISMPQKSFNATAERGEEMTFSCRA
SGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDA
EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE
GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKI
IELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP
SPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSM
PPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRT

--------------------------------------------------------------
>71127_71127_2_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000328024_NCAM2_chr21_22696703_ENST00000400546_length(transcript)=7525nt_BP=258nt
TTTCTCCAGGACACCGAGGGCGAGGAGGGTGGTACCAAGCGGCGCCCACCCTCAGAGCACTACTTCCATCTCTGATTGGCTTCGCTGGGT
GCCCGTCGCTACTCCACTCGCCGCTGATAGGCCATTCAACCGCCGCTCTGCGCGGCGCCGGCTCCGCCCCCGTCGGGTGTTTGTGGTGGG
GCTGCGGAGTCGCCGATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGCCGCCAGCAA
TCTCAATGCCTCAGAAATCTTTTAATGCCACAGCAGAGAGAGGAGAAGAAATGACATTTTCCTGCAGGGCCTCAGGCTCTCCAGAACCCG
CCATCTCCTGGTTCAGGAATGGCAAGCTCATTGAAGAAAATGAGAAGTACATATTGAAAGGGAGCAATACAGAACTCACTGTCAGGAACA
TAATCAATAGTGATGGTGGTCCTTATGTCTGCAGGGCCACAAATAAGGCAGGAGAAGATGAAAAGCAAGCTTTCCTCCAAGTCTTTGTAC
AGCCTCACATAATACAGCTTAAAAATGAAACTACATATGAGAATGGTCAAGTCACACTCGTATGTGATGCGGAAGGGGAGCCTATTCCAG
AAATCACTTGGAAAAGAGCTGTGGATGGCTTCACGTTCACTGAAGGCGATAAGAGCCTGGACGGCCGTATCGAAGTCAAAGGGCAGCATG
GAAGCTCATCACTGCATATTAAAGATGTGAAGTTGTCAGATTCAGGGAGATATGACTGTGAAGCTGCAAGCAGAATTGGAGGGCATCAAA
AGAGCATGTACCTTGATATTGAATATGCCCCCAAGTTTATATCAAACCAAACAATTTATTACTCTTGGGAAGGAAATCCTATCAATATAA
GTTGTGATGTGAAATCGAATCCACCAGCATCAATTCACTGGAGAAGAGATAAATTAGTCTTACCTGCTAAAAACACGACCAATTTAAAGA
CTTATAGTACAGGAAGAAAGATGATATTAGAGATTGCACCTACATCTGACAATGACTTTGGACGCTATAATTGCACAGCCACTAATCATA
TAGGAACAAGATTTCAAGAATATATTCTTGCTTTGGCTGACGTGCCATCCAGTCCCTATGGAGTGAAGATCATAGAGCTGTCGCAGACCA
CGGCCAAGGTTTCCTTCAACAAACCGGACTCCCATGGAGGTGTACCTATTCATCACTATCAGGTGGATGTCAAAGAAGTAGCGTCAGAAA
TCTGGAAAATTGTACGCTCCCATGGAGTTCAAACAATGGTTGTTTTGAACAACCTGGAACCAAATACAACTTATGAAATCAGGGTTGCAG
CTGTAAATGGAAAGGGACAAGGAGACTACAGTAAAATAGAAATCTTCCAAACATTACCAGTTCGTGAACCAAGTCCTCCATCCATACATG
GACAGCCAAGCAGTGGAAAGAGCTTTAAACTCAGCATCACCAAACAGGACGATGGAGGGGCCCCTATTTTGGAATACATTGTGAAATATA
GAAGTAAAGATAAGGAAGACCAATGGCTAGAGAAAAAAGTGCAAGGAAATAAAGACCACATCATTTTGGAGCATCTCCAGTGGACCATGG
GGTATGAAGTTCAGATTACAGCTGCCAATAGATTGGGATATTCTGAACCGACAGTTTATGAATTCAGCATGCCACCAAAGCCCAACATTA
TTAAAGACACGCTGTTTAATGGTCTTGGGCTTGGAGCAGTAATTGGCCTGGGAGTTGCTGCACTGCTGCTAATTCTTGTGGTAACAGACG
TCAGCTGCTTCTTTATTCGGCAATGTGGGTTGCTGATGTGCATCACTAGGAGAATGTGTGGAAAGAAAAGTGGCTCCAGTGGCAAAAGTA
AAGAACTCGAAGAAGGAAAAGCTGCATACCTGAAAGATGGATCAAAAGAACCAATAGTGGAGATGAGAACAGAGGATGAAAGAGTTACTA
ATCACGAAGATGGGAGCCCAGTAAATGAGCCAAATGAAACCACACCACTGACAGAACCTGAAAAATTGCCTTTAAAGGAAGAAGATGGGA
AAGAAGCTCTAAATCCAGAAACTATAGAAATTAAAGTTTCTAACGACATCATTCAATCAAAAGAAGACGACAGCAAAGCATAACAACAAT
ATTACAGGGGCTTGAACAACACTACGAAGAGTATTTGGATTGCGTGACCCTATGACCAAAACTATTCCATTGACCTTAATTTCTTGGGAA
ACTTCTAGCTTGGAATAGCTTGTACACATATACATATGATCAAATACTCCTGCCCATGATCCATTCCCTTTTGTTATTGTTGTTGTTGTT
GCTGTTGTTGTTAATTTTGTTAAGAATTTCAATATCAAGACTGACTGGCACCAACACTTTGGTATTCAATTTGATTCTATGACTGAAGTA
CTGGAATTTATTATGTGGCTAAAGTGCTCTATTTATTAAGAACTATATTTAATACCACCAACAAATATAGGGGTTAAGGAAAAAAAACGT
GAGCTACATGTGTAAGAAGGCCCTGCATGTGTATGAGTCCTATTCTGGGCAAATAGATTCTTAAAGTGGCTTTCAACTTCAAGATGAAGG
AGCTTAATAATGGTTACTCATTTTATCAGGGGAATTTCAGGGAACGTAGGCGTCAAAGAGCCAGTTATCTTTAGCAGATATTAAAAATTG
AAAACTTTGGAGAACTCATTTCAAGTTATGATTCAGTGCATTTTCAACATTGATTTTTGATAGACTGAAGTGCCAGATCAAAATTGTTAC
CCATTTGAAAGAATATTAGTTGTATATAAAATTAGATTAGAAAGACTTTCTAAATCTCTATCTCTTTATATATGTCCTATTCATTCACAA
TGGATTATACAAAAAAAAGTGTATTGCAAGTGAAATAATATTGATTTCTGCCCTCAGCTTCAAATAAAGTAAATTGAAATGGGAACAATA
TCAATATGGTGTCTTGATATATTTATAAATATGTGATTATCATTTATTTTTAAAATAATTTATCAAAAAACAAGTCTTTAGTGTTCAAAT
ACTTCAAATCATATCCTCAGATATATTTTTAGCCCATGGTTTTATATAATCTTTAAGAACTAATTTTACCACTGTTATAGGTTCACCATT
AAATATAATTGGCTAATAAAAATTTTAAGGTTGACTAAATTAAGAAGAAATTATTTAACATTTTAATGTGCCATAAAAGAGTAAATGATA
AATAATTAAATGCCACTATGTGTTCTATTCCGGATGTTCTAGCTAGAAGTCATTTTAAGATTTTGATAAACAACTTTGGTTGAAGAAATT
CCTTAAGTATTCAACACAAACTTTCTAATATCTTTTGTTAGGGTTATACCAGAATAAAATGCTTCTTTACTTCCAAGCTATGCAAGCTCC
CAGAGGTAATAGAGTGACACATGATTTAACTTATATGTAAGGTTTAAAAAAGTATTTATCATTATAAACATACATACCATTTGGGAGCAG
GTTTATTAACCTTGAGAGCCAAAGGTTTCCTTAGGCCCTGTAACATTCAGAACCTTTGGTGTTTCAGGTGGTATTATAGCTCAAATAGTG
ACAGGACAGGGAATGCGTTCCAAAGGAATATTGGAGCAATTTTAACATTGCAGAAACCTGCTCTGGGTGTGTCTCTCTGTAGAGATAACC
TGATGATTATTAAATGTAAAATTAAGGCAACTCATGAATATTTTTATTTACAAAGTGCTTGAAACTCAGCCAAGGAGAGAAAACTAAGTA
CTTTTATATAATTCATCACTTTTCTGGCTACAGCAGGACAGAATATGACCATCTTCGTTTGAAGGCACCAAATCGTCGCAGTGTCTTTGC
CATAAGTTGCAGGGTTAAATGCGGGAATCTCTCCTTGCGTTCCTGTCTGGCGTATTCTGAAGAAAAGAACAGAATTCTTGTGCCTACCTA
AGAATTTGAGTAGTGTCTAAACAAACAAAGCAGTTAGGTCATTTTAACTGACTTGATTATCCAACTGGTCTTTGACAGATTTGACTGTTC
ATATTTAGTTTATGTTTGTCTGATCATCCAGTTTGCTTTATTTTGCTGTGTTTTATTTTGTTGTTTGTTTTGTTTTGTACCAGTGTACTA
AAACTAGTCAAAATACTTGAATTAGTTTGTTTGTGCAAAGTGTACAAGCTTAGTAAAGTGTCCATGAAGCAATAGCCATGAATGCTAATT
ATTTCTAAATAGGGCCACATGGTTTTAAACTAATGATGGTGAAAGAAATACGATGACTGAGAAAGTCATTTCGCATGTTTACTATTGTTA
TATTCGTGCTTTACTTCAAGAGTGCAGAAATCATAATAAATAACAAACTATTTTTGTGTTTTCTCAATGTGACATTTCTGTTTCTCTCAT
TTATTCGGATTTTCCTTGTAAAGAAATTGACATATATTTCATATATATATACACATATATATATATACACATATATATACATATATATAT
ATGATGTTAAATTTCCTGCCACTCATGTGGAGTAATGATCTGAAATTAACAGATAATCTGAAGCTAATTATATTCAGACTATTTCAAGTG
CACTGTTTCAGTTGCCCGGGTGGTCCTTACCTCTTGTCCTTGAAATCCATGCCATGCTGAAGCAAGGCAATACTGTGATAAAGTATTTTT
TTTAATATTTCAATGGAATGCTCCAAATGATTTATAAAAATTTCAAAATAAAAGATGGCTTGTAGTAAATTGTAAAATATGAGTAGAACT
GAAATAACCTGTTTCATTCTTATTCTAGATTAAACAAACATATACATATAACCATATAAATGTTATTTTTATTGTCTGAGAGTACTCTTA
AATATTAGTATAAAGTGTCAAAAGAATTGACTGAATATAAGTACTGTTAAAATAATTTGAACCCTATGATATTTTAAACCAAGAGGCAAA
GATATCACCTAAAACTTGGTATTTCTTGATAGGTTAGGTGCAATTAGGCAGTGACAATCTGTATTCAACAACATATAAGAGGAAAGAGTA
ATATCAGAATTTTGACACAAATTAATGTGTCAACATATTTTACAATGATTGTCAAAGGAATTTAAGAATTGTATTTTTAAAGATTTATTT
ATTATTTTTGTGGGCTAAGACATTGCCATTCTATTGATACTAATGTCTAACATTAATGTTTCTTGTTTTCTTTTATTTTTAATATTAATA
ACTATAAAAGCATTTTTCAAAGGCTATTTGATCCAGCACACTTCATATGGATCTTAGTCTTTGAATTAAATATTTATATAAATAGATTTT
ATTAATCAAATTATTTATTTGTGTGCCAACAATTAATTGTAACTTTATGATCATATCTTTGTTTATGCTTCTTATTTTAAATAATTAAGA
TGTATCTGTGCCTTTTAATTAGCATGACAGTCTGCTTTATTAAAAGAAAAAAACTACAATTAACATCATTACTAGTATATTTTGCTTAGA
TTTGAGATACTCAAATGATGCTGTCTTATTTACAGTCAGTAATTAAGTTCAATTCAAACTATTTTACCTTGAATATAAAATCTAAATATA
ATAAACTATACTGTATAATTTACTTTAATTCATGTCAAAACAATTCTTTTTATACACACACATGAAATATTCTTAATCTGTTCTGTATTG
TTTTTCTAAACAATAAATACATTCTAGATATTGTTGAAATTAAATTTTGCCAGTTGTAAGACAAAGACAACAGATAACTTTTGAAAATCA
AGCAAATTACTATGGTGTTTCTTGGGTCTTCATTATTCCATTTATATATATTTTTTATTTCGAATAATAAATCAACCTTTATTTTTGGCA
ATAAGATTATCACTGACGAAAATATGTACAGTTCAAGAAGTAGAAATAATATTTTCCATTAGTTAATTTAGGAAATATTGGAATAGCATA
TTATAATTATTTATGAGGTTCCCAATGTTGTTTTTCACAGAAAATAAGGTAAACATTCAACTTAAATCCCCCATGAAGTTTTTTCATGCT
CATACTCATAATCATTATCACATAATGTGCTTATTCAACAAACTTTGTATCTGGATATATTTTTAACAATAAGTTTGTTAGCATTATTTA
TTTATCTTTAGAGAGAAAATATTTGCATCTGTTTATTTACCCTTTGAAGCATTAATACTTAGTCACTCACATTGAAATTGCATATGGATG
TATCAACATAGGCTAAAATTAAATTATGGATGTCGCAGAAATGAAATACTTCATCTTAGAAGGTAAAATTTTCAAGAAAGTATTTTATTC
ATGGACTTAATAATGTCTTAAGATGAAACAATTTTATGTCCAAATGAGAAATTTATAAAAAGACCCACATATAGTAGTTGCTGAACAAAC
ATAATTTTCTTCCAGCTCCCATCCTTCCTTTTTGAAAAATTGAATTTACCCATGTAGATGCAGCTATTTACAATTATACAAGAATGCGAA
TAGATTAATTATATCTTCTCATATAAAGGCAAAGAATTTTATATTATATATAATGCTAAATATTTATTTGATAACACAATATTCTTAGAA
AAATAGTTTATTACTTTAGGATTTTATCTATAACATAAATATATTATTTGTTATTACCTCTTTAAATTTTCATTTTATACAATTTTTGAG
ATTCTGGCCACACAACATTCAGAATTATTGCTCATGTAAATTTAAATATTGCTACTTATTTTTTTTCTTTTCTGAAATGAAAACATGAAT
CTTTTGGCATCTGTTTTTAGCCTCCCATGGAAGACAGTAAGCAAAACCATCACTGTTGGAGAATTTCAAATCACAACCCGACATAGGAGA
GTAGAGAAACAAAGAAATGAGTGGATCTAGAAAGGCAAACTGAATTGCTATATTTGGAATAGCTAAGAAGGACCTGACTTTGAGAAGTGC
TAGACCAGGGACTAGGAACGTTGCTTAGATAAAAATTATGGCCGATTACACTGATGCGAAGGAGAAAACAGTGTAACACAGAGGAGAAAG
TTAACAGAGATAGAATCTATGATTTAATTTTGCAAATAGTTTTTTTAGAGAACAACATGCATACTATAAAAGAAATGATACTATTAAGAA
CAAACCTACTTGTTCCAACTCTTAAAGAAATATTCATGGTTTAGCATTTGCCTCTAAACCCTGTTAGAAATATGTGAAGTTAGAAATAAA
GGTTTTTTTAAAAAAAAAGCTTTTTTGGTATGTGAACTGTATGCTGTGCTCAGTATGTACTGAAACATACTATCTTTTATTTTCTTTAAT
TTATATATTCCATTCAAATTCTATATTCTTAAGTTAGCTACCACAACGTTTTCTTATTGTTTCAATATGGTATGTCCCAATGAAATGCTG
TATATATATGTCTAAACTGTAAAAATTATACTGCAAATGTTGAAGTTTTGTATTTATGAGAGACATTGAAAGTATGGCTTACAGTATATC

>71127_71127_2_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000328024_NCAM2_chr21_22696703_ENST00000400546_length(amino acids)=693AA_BP=62
MIGFAGCPSLLHSPLIGHSTAALRGAGSAPVGCLWWGCGVADPAGSARTMGTRDDEYDYLFKVPPAISMPQKSFNATAERGEEMTFSCRA
SGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDA
EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE
GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKI
IELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREP
SPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSM
PPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRT

--------------------------------------------------------------
>71127_71127_3_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000328024_NCAM2_chr21_22696703_ENST00000535285_length(transcript)=905nt_BP=258nt
TTTCTCCAGGACACCGAGGGCGAGGAGGGTGGTACCAAGCGGCGCCCACCCTCAGAGCACTACTTCCATCTCTGATTGGCTTCGCTGGGT
GCCCGTCGCTACTCCACTCGCCGCTGATAGGCCATTCAACCGCCGCTCTGCGCGGCGCCGGCTCCGCCCCCGTCGGGTGTTTGTGGTGGG
GCTGCGGAGTCGCCGATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGCCGCCAGCAA
TCTCAATGCCTCAGAAATCTTTTAATGCCACAGCAGAGAGAGGAGAAGAAATGACATTTTCCTGCAGGGCCTCAGGCTCTCCAGAACCCG
CCATCTCCTGGTTCAGGAATGGCAAGCTCATTGAAGAAAATGAGAAGTACATATTGAAAGGGAGCAATACAGAACTCACTGTCAGGAACA
TAATCAATAGTGATGGTGGTCCTTATGTCTGCAGGGCCACAAATAAGGCAGGAGAAGATGAAAAGCAAGCTTTCCTCCAAGTCTTTGTAC
AGCCTCACATAATACAGCTTAAAAATGAAACTACATATGAGAATGGTCAAGTCACACTCGTATGTGATGCGGAAGGGGAGCCTATTCCAG
AAATCACTTGGAAAAGAGCTGTGGATGGCTTCACGTTCACTGAAGGCGATAAGAGCCTGGACGGCCGTATCGAAGTCAAAGGGCAGCATG
GAAGCTCATCACTGCATATTAAAGATGTGAAGTTGTCAGATTCAGGGAGATATGACTGTGAAGCTGCAAGCAGAATTGGAGGGCATCAAA
AGAGCATGTACCTTGATATTGAATCTTAAACAGATTTCTTGGCATTCTTCCAGTTCATTTTCAACATTTCCGAGGCGTTACTTTACTAAG

>71127_71127_3_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000328024_NCAM2_chr21_22696703_ENST00000535285_length(amino acids)=255AA_BP=62
MIGFAGCPSLLHSPLIGHSTAALRGAGSAPVGCLWWGCGVADPAGSARTMGTRDDEYDYLFKVPPAISMPQKSFNATAERGEEMTFSCRA
SGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDA

--------------------------------------------------------------
>71127_71127_4_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000594216_NCAM2_chr21_22696703_ENST00000284894_length(transcript)=1959nt_BP=64nt
GATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGCCGCCAGCAATCTCAATGCCTCAG
AAATCTTTTAATGCCACAGCAGAGAGAGGAGAAGAAATGACATTTTCCTGCAGGGCCTCAGGCTCTCCAGAACCCGCCATCTCCTGGTTC
AGGAATGGCAAGCTCATTGAAGAAAATGAGAAGTACATATTGAAAGGGAGCAATACAGAACTCACTGTCAGGAACATAATCAATAGTGAT
GGTGGTCCTTATGTCTGCAGGGCCACAAATAAGGCAGGAGAAGATGAAAAGCAAGCTTTCCTCCAAGTCTTTGTACAGCCTCACATAATA
CAGCTTAAAAATGAAACTACATATGAGAATGGTCAAGTCACACTCGTATGTGATGCGGAAGGGGAGCCTATTCCAGAAATCACTTGGAAA
AGAGCTGTGGATGGCTTCACGTTCACTGAAGGCGATAAGAGCCTGGACGGCCGTATCGAAGTCAAAGGGCAGCATGGAAGCTCATCACTG
CATATTAAAGATGTGAAGTTGTCAGATTCAGGGAGATATGACTGTGAAGCTGCAAGCAGAATTGGAGGGCATCAAAAGAGCATGTACCTT
GATATTGAATATGCCCCCAAGTTTATATCAAACCAAACAATTTATTACTCTTGGGAAGGAAATCCTATCAATATAAGTTGTGATGTGAAA
TCGAATCCACCAGCATCAATTCACTGGAGAAGAGATAAATTAGTCTTACCTGCTAAAAACACGACCAATTTAAAGACTTATAGTACAGGA
AGAAAGATGATATTAGAGATTGCACCTACATCTGACAATGACTTTGGACGCTATAATTGCACAGCCACTAATCATATAGGAACAAGATTT
CAAGAATATATTCTTGCTTTGGCTGACGTGCCATCCAGTCCCTATGGAGTGAAGATCATAGAGCTGTCGCAGACCACGGCCAAGGTTTCC
TTCAACAAACCGGACTCCCATGGAGGTGTACCTATTCATCACTATCAGGTGGATGTCAAAGAAGTAGCGTCAGAAATCTGGAAAATTGTA
CGCTCCCATGGAGTTCAAACAATGGTTGTTTTGAACAACCTGGAACCAAATACAACTTATGAAATCAGGGTTGCAGCTGTAAATGGAAAG
GGACAAGGAGACTACAGTAAAATAGAAATCTTCCAAACATTACCAGTTCGTGAACCAAGTCCTCCATCCATACATGGACAGCCAAGCAGT
GGAAAGAGCTTTAAACTCAGCATCACCAAACAGGACGATGGAGGGGCCCCTATTTTGGAATACATTGTGAAATATAGAAGTAAAGATAAG
GAAGACCAATGGCTAGAGAAAAAAGTGCAAGGAAATAAAGACCACATCATTTTGGAGCATCTCCAGTGGACCATGGGGTATGAAGTTCAG
ATTACAGCTGCCAATAGATTGGGATATTCTGAACCGACAGTTTATGAATTCAGCATGCCACCAAAGCCCAACATTATTAAAGACACGCTG
TTTAATGGTCTTGGGCTTGGAGCAGTAATTGGCCTGGGAGTTGCTGCACTGCTGCTAATTCTTGTGGTAACAGACGTCAGCTGCTTCTTT
ATTCGGCAATGTGGGTTGCTGATGTGCATCACTAGGAGAATGTGTGGAAAGAAAAGTGGCTCCAGTGGCAAAAGTAAAGAACTCGAAGAA
GGAAAAGCTGCATACCTGAAAGATGGATCAAAAGAACCAATAGTGGAGATGAGAACAGAGGATGAAAGAGTTACTAATCACGAAGATGGG
AGCCCAGTAAATGAGCCAAATGAAACCACACCACTGACAGAACCTGAAAAATTGCCTTTAAAGGAAGAAGATGGGAAAGAAGCTCTAAAT

>71127_71127_4_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000594216_NCAM2_chr21_22696703_ENST00000284894_length(amino acids)=644AA_BP=13
MGTRDDEYDYLFKVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRA
TNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS
DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIA
PTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM
VVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKK
VQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLM
CITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKV

--------------------------------------------------------------
>71127_71127_5_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000594216_NCAM2_chr21_22696703_ENST00000400546_length(transcript)=7331nt_BP=64nt
GATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGCCGCCAGCAATCTCAATGCCTCAG
AAATCTTTTAATGCCACAGCAGAGAGAGGAGAAGAAATGACATTTTCCTGCAGGGCCTCAGGCTCTCCAGAACCCGCCATCTCCTGGTTC
AGGAATGGCAAGCTCATTGAAGAAAATGAGAAGTACATATTGAAAGGGAGCAATACAGAACTCACTGTCAGGAACATAATCAATAGTGAT
GGTGGTCCTTATGTCTGCAGGGCCACAAATAAGGCAGGAGAAGATGAAAAGCAAGCTTTCCTCCAAGTCTTTGTACAGCCTCACATAATA
CAGCTTAAAAATGAAACTACATATGAGAATGGTCAAGTCACACTCGTATGTGATGCGGAAGGGGAGCCTATTCCAGAAATCACTTGGAAA
AGAGCTGTGGATGGCTTCACGTTCACTGAAGGCGATAAGAGCCTGGACGGCCGTATCGAAGTCAAAGGGCAGCATGGAAGCTCATCACTG
CATATTAAAGATGTGAAGTTGTCAGATTCAGGGAGATATGACTGTGAAGCTGCAAGCAGAATTGGAGGGCATCAAAAGAGCATGTACCTT
GATATTGAATATGCCCCCAAGTTTATATCAAACCAAACAATTTATTACTCTTGGGAAGGAAATCCTATCAATATAAGTTGTGATGTGAAA
TCGAATCCACCAGCATCAATTCACTGGAGAAGAGATAAATTAGTCTTACCTGCTAAAAACACGACCAATTTAAAGACTTATAGTACAGGA
AGAAAGATGATATTAGAGATTGCACCTACATCTGACAATGACTTTGGACGCTATAATTGCACAGCCACTAATCATATAGGAACAAGATTT
CAAGAATATATTCTTGCTTTGGCTGACGTGCCATCCAGTCCCTATGGAGTGAAGATCATAGAGCTGTCGCAGACCACGGCCAAGGTTTCC
TTCAACAAACCGGACTCCCATGGAGGTGTACCTATTCATCACTATCAGGTGGATGTCAAAGAAGTAGCGTCAGAAATCTGGAAAATTGTA
CGCTCCCATGGAGTTCAAACAATGGTTGTTTTGAACAACCTGGAACCAAATACAACTTATGAAATCAGGGTTGCAGCTGTAAATGGAAAG
GGACAAGGAGACTACAGTAAAATAGAAATCTTCCAAACATTACCAGTTCGTGAACCAAGTCCTCCATCCATACATGGACAGCCAAGCAGT
GGAAAGAGCTTTAAACTCAGCATCACCAAACAGGACGATGGAGGGGCCCCTATTTTGGAATACATTGTGAAATATAGAAGTAAAGATAAG
GAAGACCAATGGCTAGAGAAAAAAGTGCAAGGAAATAAAGACCACATCATTTTGGAGCATCTCCAGTGGACCATGGGGTATGAAGTTCAG
ATTACAGCTGCCAATAGATTGGGATATTCTGAACCGACAGTTTATGAATTCAGCATGCCACCAAAGCCCAACATTATTAAAGACACGCTG
TTTAATGGTCTTGGGCTTGGAGCAGTAATTGGCCTGGGAGTTGCTGCACTGCTGCTAATTCTTGTGGTAACAGACGTCAGCTGCTTCTTT
ATTCGGCAATGTGGGTTGCTGATGTGCATCACTAGGAGAATGTGTGGAAAGAAAAGTGGCTCCAGTGGCAAAAGTAAAGAACTCGAAGAA
GGAAAAGCTGCATACCTGAAAGATGGATCAAAAGAACCAATAGTGGAGATGAGAACAGAGGATGAAAGAGTTACTAATCACGAAGATGGG
AGCCCAGTAAATGAGCCAAATGAAACCACACCACTGACAGAACCTGAAAAATTGCCTTTAAAGGAAGAAGATGGGAAAGAAGCTCTAAAT
CCAGAAACTATAGAAATTAAAGTTTCTAACGACATCATTCAATCAAAAGAAGACGACAGCAAAGCATAACAACAATATTACAGGGGCTTG
AACAACACTACGAAGAGTATTTGGATTGCGTGACCCTATGACCAAAACTATTCCATTGACCTTAATTTCTTGGGAAACTTCTAGCTTGGA
ATAGCTTGTACACATATACATATGATCAAATACTCCTGCCCATGATCCATTCCCTTTTGTTATTGTTGTTGTTGTTGCTGTTGTTGTTAA
TTTTGTTAAGAATTTCAATATCAAGACTGACTGGCACCAACACTTTGGTATTCAATTTGATTCTATGACTGAAGTACTGGAATTTATTAT
GTGGCTAAAGTGCTCTATTTATTAAGAACTATATTTAATACCACCAACAAATATAGGGGTTAAGGAAAAAAAACGTGAGCTACATGTGTA
AGAAGGCCCTGCATGTGTATGAGTCCTATTCTGGGCAAATAGATTCTTAAAGTGGCTTTCAACTTCAAGATGAAGGAGCTTAATAATGGT
TACTCATTTTATCAGGGGAATTTCAGGGAACGTAGGCGTCAAAGAGCCAGTTATCTTTAGCAGATATTAAAAATTGAAAACTTTGGAGAA
CTCATTTCAAGTTATGATTCAGTGCATTTTCAACATTGATTTTTGATAGACTGAAGTGCCAGATCAAAATTGTTACCCATTTGAAAGAAT
ATTAGTTGTATATAAAATTAGATTAGAAAGACTTTCTAAATCTCTATCTCTTTATATATGTCCTATTCATTCACAATGGATTATACAAAA
AAAAGTGTATTGCAAGTGAAATAATATTGATTTCTGCCCTCAGCTTCAAATAAAGTAAATTGAAATGGGAACAATATCAATATGGTGTCT
TGATATATTTATAAATATGTGATTATCATTTATTTTTAAAATAATTTATCAAAAAACAAGTCTTTAGTGTTCAAATACTTCAAATCATAT
CCTCAGATATATTTTTAGCCCATGGTTTTATATAATCTTTAAGAACTAATTTTACCACTGTTATAGGTTCACCATTAAATATAATTGGCT
AATAAAAATTTTAAGGTTGACTAAATTAAGAAGAAATTATTTAACATTTTAATGTGCCATAAAAGAGTAAATGATAAATAATTAAATGCC
ACTATGTGTTCTATTCCGGATGTTCTAGCTAGAAGTCATTTTAAGATTTTGATAAACAACTTTGGTTGAAGAAATTCCTTAAGTATTCAA
CACAAACTTTCTAATATCTTTTGTTAGGGTTATACCAGAATAAAATGCTTCTTTACTTCCAAGCTATGCAAGCTCCCAGAGGTAATAGAG
TGACACATGATTTAACTTATATGTAAGGTTTAAAAAAGTATTTATCATTATAAACATACATACCATTTGGGAGCAGGTTTATTAACCTTG
AGAGCCAAAGGTTTCCTTAGGCCCTGTAACATTCAGAACCTTTGGTGTTTCAGGTGGTATTATAGCTCAAATAGTGACAGGACAGGGAAT
GCGTTCCAAAGGAATATTGGAGCAATTTTAACATTGCAGAAACCTGCTCTGGGTGTGTCTCTCTGTAGAGATAACCTGATGATTATTAAA
TGTAAAATTAAGGCAACTCATGAATATTTTTATTTACAAAGTGCTTGAAACTCAGCCAAGGAGAGAAAACTAAGTACTTTTATATAATTC
ATCACTTTTCTGGCTACAGCAGGACAGAATATGACCATCTTCGTTTGAAGGCACCAAATCGTCGCAGTGTCTTTGCCATAAGTTGCAGGG
TTAAATGCGGGAATCTCTCCTTGCGTTCCTGTCTGGCGTATTCTGAAGAAAAGAACAGAATTCTTGTGCCTACCTAAGAATTTGAGTAGT
GTCTAAACAAACAAAGCAGTTAGGTCATTTTAACTGACTTGATTATCCAACTGGTCTTTGACAGATTTGACTGTTCATATTTAGTTTATG
TTTGTCTGATCATCCAGTTTGCTTTATTTTGCTGTGTTTTATTTTGTTGTTTGTTTTGTTTTGTACCAGTGTACTAAAACTAGTCAAAAT
ACTTGAATTAGTTTGTTTGTGCAAAGTGTACAAGCTTAGTAAAGTGTCCATGAAGCAATAGCCATGAATGCTAATTATTTCTAAATAGGG
CCACATGGTTTTAAACTAATGATGGTGAAAGAAATACGATGACTGAGAAAGTCATTTCGCATGTTTACTATTGTTATATTCGTGCTTTAC
TTCAAGAGTGCAGAAATCATAATAAATAACAAACTATTTTTGTGTTTTCTCAATGTGACATTTCTGTTTCTCTCATTTATTCGGATTTTC
CTTGTAAAGAAATTGACATATATTTCATATATATATACACATATATATATATACACATATATATACATATATATATATGATGTTAAATTT
CCTGCCACTCATGTGGAGTAATGATCTGAAATTAACAGATAATCTGAAGCTAATTATATTCAGACTATTTCAAGTGCACTGTTTCAGTTG
CCCGGGTGGTCCTTACCTCTTGTCCTTGAAATCCATGCCATGCTGAAGCAAGGCAATACTGTGATAAAGTATTTTTTTTAATATTTCAAT
GGAATGCTCCAAATGATTTATAAAAATTTCAAAATAAAAGATGGCTTGTAGTAAATTGTAAAATATGAGTAGAACTGAAATAACCTGTTT
CATTCTTATTCTAGATTAAACAAACATATACATATAACCATATAAATGTTATTTTTATTGTCTGAGAGTACTCTTAAATATTAGTATAAA
GTGTCAAAAGAATTGACTGAATATAAGTACTGTTAAAATAATTTGAACCCTATGATATTTTAAACCAAGAGGCAAAGATATCACCTAAAA
CTTGGTATTTCTTGATAGGTTAGGTGCAATTAGGCAGTGACAATCTGTATTCAACAACATATAAGAGGAAAGAGTAATATCAGAATTTTG
ACACAAATTAATGTGTCAACATATTTTACAATGATTGTCAAAGGAATTTAAGAATTGTATTTTTAAAGATTTATTTATTATTTTTGTGGG
CTAAGACATTGCCATTCTATTGATACTAATGTCTAACATTAATGTTTCTTGTTTTCTTTTATTTTTAATATTAATAACTATAAAAGCATT
TTTCAAAGGCTATTTGATCCAGCACACTTCATATGGATCTTAGTCTTTGAATTAAATATTTATATAAATAGATTTTATTAATCAAATTAT
TTATTTGTGTGCCAACAATTAATTGTAACTTTATGATCATATCTTTGTTTATGCTTCTTATTTTAAATAATTAAGATGTATCTGTGCCTT
TTAATTAGCATGACAGTCTGCTTTATTAAAAGAAAAAAACTACAATTAACATCATTACTAGTATATTTTGCTTAGATTTGAGATACTCAA
ATGATGCTGTCTTATTTACAGTCAGTAATTAAGTTCAATTCAAACTATTTTACCTTGAATATAAAATCTAAATATAATAAACTATACTGT
ATAATTTACTTTAATTCATGTCAAAACAATTCTTTTTATACACACACATGAAATATTCTTAATCTGTTCTGTATTGTTTTTCTAAACAAT
AAATACATTCTAGATATTGTTGAAATTAAATTTTGCCAGTTGTAAGACAAAGACAACAGATAACTTTTGAAAATCAAGCAAATTACTATG
GTGTTTCTTGGGTCTTCATTATTCCATTTATATATATTTTTTATTTCGAATAATAAATCAACCTTTATTTTTGGCAATAAGATTATCACT
GACGAAAATATGTACAGTTCAAGAAGTAGAAATAATATTTTCCATTAGTTAATTTAGGAAATATTGGAATAGCATATTATAATTATTTAT
GAGGTTCCCAATGTTGTTTTTCACAGAAAATAAGGTAAACATTCAACTTAAATCCCCCATGAAGTTTTTTCATGCTCATACTCATAATCA
TTATCACATAATGTGCTTATTCAACAAACTTTGTATCTGGATATATTTTTAACAATAAGTTTGTTAGCATTATTTATTTATCTTTAGAGA
GAAAATATTTGCATCTGTTTATTTACCCTTTGAAGCATTAATACTTAGTCACTCACATTGAAATTGCATATGGATGTATCAACATAGGCT
AAAATTAAATTATGGATGTCGCAGAAATGAAATACTTCATCTTAGAAGGTAAAATTTTCAAGAAAGTATTTTATTCATGGACTTAATAAT
GTCTTAAGATGAAACAATTTTATGTCCAAATGAGAAATTTATAAAAAGACCCACATATAGTAGTTGCTGAACAAACATAATTTTCTTCCA
GCTCCCATCCTTCCTTTTTGAAAAATTGAATTTACCCATGTAGATGCAGCTATTTACAATTATACAAGAATGCGAATAGATTAATTATAT
CTTCTCATATAAAGGCAAAGAATTTTATATTATATATAATGCTAAATATTTATTTGATAACACAATATTCTTAGAAAAATAGTTTATTAC
TTTAGGATTTTATCTATAACATAAATATATTATTTGTTATTACCTCTTTAAATTTTCATTTTATACAATTTTTGAGATTCTGGCCACACA
ACATTCAGAATTATTGCTCATGTAAATTTAAATATTGCTACTTATTTTTTTTCTTTTCTGAAATGAAAACATGAATCTTTTGGCATCTGT
TTTTAGCCTCCCATGGAAGACAGTAAGCAAAACCATCACTGTTGGAGAATTTCAAATCACAACCCGACATAGGAGAGTAGAGAAACAAAG
AAATGAGTGGATCTAGAAAGGCAAACTGAATTGCTATATTTGGAATAGCTAAGAAGGACCTGACTTTGAGAAGTGCTAGACCAGGGACTA
GGAACGTTGCTTAGATAAAAATTATGGCCGATTACACTGATGCGAAGGAGAAAACAGTGTAACACAGAGGAGAAAGTTAACAGAGATAGA
ATCTATGATTTAATTTTGCAAATAGTTTTTTTAGAGAACAACATGCATACTATAAAAGAAATGATACTATTAAGAACAAACCTACTTGTT
CCAACTCTTAAAGAAATATTCATGGTTTAGCATTTGCCTCTAAACCCTGTTAGAAATATGTGAAGTTAGAAATAAAGGTTTTTTTAAAAA
AAAAGCTTTTTTGGTATGTGAACTGTATGCTGTGCTCAGTATGTACTGAAACATACTATCTTTTATTTTCTTTAATTTATATATTCCATT
CAAATTCTATATTCTTAAGTTAGCTACCACAACGTTTTCTTATTGTTTCAATATGGTATGTCCCAATGAAATGCTGTATATATATGTCTA
AACTGTAAAAATTATACTGCAAATGTTGAAGTTTTGTATTTATGAGAGACATTGAAAGTATGGCTTACAGTATATCAAACTTGTCACACT

>71127_71127_5_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000594216_NCAM2_chr21_22696703_ENST00000400546_length(amino acids)=644AA_BP=13
MGTRDDEYDYLFKVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRA
TNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS
DSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIA
PTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTM
VVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKK
VQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQCGLLM
CITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKV

--------------------------------------------------------------
>71127_71127_6_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000594216_NCAM2_chr21_22696703_ENST00000535285_length(transcript)=711nt_BP=64nt
GATCCCGCCGGAAGCGCCAGGACAATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAGTGCCGCCAGCAATCTCAATGCCTCAG
AAATCTTTTAATGCCACAGCAGAGAGAGGAGAAGAAATGACATTTTCCTGCAGGGCCTCAGGCTCTCCAGAACCCGCCATCTCCTGGTTC
AGGAATGGCAAGCTCATTGAAGAAAATGAGAAGTACATATTGAAAGGGAGCAATACAGAACTCACTGTCAGGAACATAATCAATAGTGAT
GGTGGTCCTTATGTCTGCAGGGCCACAAATAAGGCAGGAGAAGATGAAAAGCAAGCTTTCCTCCAAGTCTTTGTACAGCCTCACATAATA
CAGCTTAAAAATGAAACTACATATGAGAATGGTCAAGTCACACTCGTATGTGATGCGGAAGGGGAGCCTATTCCAGAAATCACTTGGAAA
AGAGCTGTGGATGGCTTCACGTTCACTGAAGGCGATAAGAGCCTGGACGGCCGTATCGAAGTCAAAGGGCAGCATGGAAGCTCATCACTG
CATATTAAAGATGTGAAGTTGTCAGATTCAGGGAGATATGACTGTGAAGCTGCAAGCAGAATTGGAGGGCATCAAAAGAGCATGTACCTT

>71127_71127_6_RAB11B-NCAM2_RAB11B_chr19_8455340_ENST00000594216_NCAM2_chr21_22696703_ENST00000535285_length(amino acids)=206AA_BP=13
MGTRDDEYDYLFKVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRA
TNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAB11B-NCAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB11B-NCAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB11B-NCAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource