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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB11FIP1-HTRA4 (FusionGDB2 ID:71138)

Fusion Gene Summary for RAB11FIP1-HTRA4

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB11FIP1-HTRA4
Fusion gene ID: 71138
HgeneTgene
Gene symbol

RAB11FIP1

HTRA4

Gene ID

80223

203100

Gene nameRAB11 family interacting protein 1HtrA serine peptidase 4
SynonymsNOEL1A|RCP|rab11-FIP1-
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionrab11 family-interacting protein 1RAB11 coupling proteinRAB11 family interacting protein 1 (class I)Rab effector proteinRab-interacting recycling proteinserine protease HTRA4high-temperature requirement factor A4probable serine protease HTRA4
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000523182, ENST00000522727, 
ENST00000287263, ENST00000330843, 
ENST00000524118, 		ENST00000302495, 
Fusion gene scores* DoF score10 X 14 X 4=5605 X 7 X 5=175
# samples 127
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB11FIP1 [Title/Abstract] AND HTRA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB11FIP1(37727938)-HTRA4(38836734), # samples:3
Anticipated loss of major functional domain due to fusion event.RAB11FIP1-HTRA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB11FIP1

GO:0070164

negative regulation of adiponectin secretion

24040321

TgeneHTRA4

GO:0006508

proteolysis

18387192


check buttonFusion gene breakpoints across RAB11FIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTRA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
ChimerDB4BRCATCGA-BH-A0EIRAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
ChimerDB4BRCATCGA-BH-A0EIRAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+


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Fusion Gene ORF analysis for RAB11FIP1-HTRA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000523182ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
5UTR-3CDSENST00000523182ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
5UTR-3CDSENST00000523182ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
5UTR-3CDSENST00000523182ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+
Frame-shiftENST00000522727ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
Frame-shiftENST00000522727ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
Frame-shiftENST00000522727ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
Frame-shiftENST00000522727ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+
In-frameENST00000287263ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
In-frameENST00000287263ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
In-frameENST00000287263ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
In-frameENST00000287263ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+
In-frameENST00000330843ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
In-frameENST00000330843ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
In-frameENST00000330843ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
In-frameENST00000330843ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+
intron-3CDSENST00000524118ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
intron-3CDSENST00000524118ENST00000302495RAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
intron-3CDSENST00000524118ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
intron-3CDSENST00000524118ENST00000302495RAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287263RAB11FIP1chr837727938-ENST00000302495HTRA4chr838836734+27861757262221731
ENST00000330843RAB11FIP1chr837727938-ENST00000302495HTRA4chr838836734+467536461341101365
ENST00000287263RAB11FIP1chr837727937-ENST00000302495HTRA4chr838839171+27531757262188720
ENST00000330843RAB11FIP1chr837727937-ENST00000302495HTRA4chr838839171+464236461340771354
ENST00000287263RAB11FIP1chr837727937-ENST00000302495HTRA4chr838836733+27861757262221731
ENST00000330843RAB11FIP1chr837727937-ENST00000302495HTRA4chr838836733+467536461341101365
ENST00000287263RAB11FIP1chr837727938-ENST00000302495HTRA4chr838839172+27531757262188720
ENST00000330843RAB11FIP1chr837727938-ENST00000302495HTRA4chr838839172+464236461340771354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287263ENST00000302495RAB11FIP1chr837727938-HTRA4chr838836734+0.0016380570.9983619
ENST00000330843ENST00000302495RAB11FIP1chr837727938-HTRA4chr838836734+0.0007357690.9992642
ENST00000287263ENST00000302495RAB11FIP1chr837727937-HTRA4chr838839171+0.0016665280.9983335
ENST00000330843ENST00000302495RAB11FIP1chr837727937-HTRA4chr838839171+0.0015020960.99849796
ENST00000287263ENST00000302495RAB11FIP1chr837727937-HTRA4chr838836733+0.0016380570.9983619
ENST00000330843ENST00000302495RAB11FIP1chr837727937-HTRA4chr838836733+0.0007357690.9992642
ENST00000287263ENST00000302495RAB11FIP1chr837727938-HTRA4chr838839172+0.0016665280.9983335
ENST00000330843ENST00000302495RAB11FIP1chr837727938-HTRA4chr838839172+0.0015020960.99849796

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Fusion Genomic Features for RAB11FIP1-HTRA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAB11FIP1chr837727937-HTRA4chr838836733+6.00E-050.99994004
RAB11FIP1chr837727937-HTRA4chr838836733+6.00E-050.99994004
RAB11FIP1chr837727937-HTRA4chr838839171+8.68E-060.9999913
RAB11FIP1chr837727937-HTRA4chr838839171+8.68E-060.9999913
RAB11FIP1chr837727937-HTRA4chr838836733+6.00E-050.99994004
RAB11FIP1chr837727937-HTRA4chr838836733+6.00E-050.99994004
RAB11FIP1chr837727937-HTRA4chr838839171+8.68E-060.9999913
RAB11FIP1chr837727937-HTRA4chr838839171+8.68E-060.9999913

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAB11FIP1-HTRA4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37727938/chr8:38836734)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-45209_218577650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-56209_21812111284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-56556_60912111284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-45209_218577650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-56209_21812111284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-56556_60912111284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-45209_218577650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-56209_21812111284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-56556_60912111284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-45209_218577650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-56209_21812111284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-56556_60912111284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-451_126577650.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-561_12612111284.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-451_126577650.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-561_12612111284.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-451_126577650.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-561_12612111284.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-451_126577650.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-561_12612111284.0DomainC2
TgeneHTRA4chr8:37727937chr8:38836733ENST0000030249539383_474322477.0DomainPDZ
TgeneHTRA4chr8:37727937chr8:38839171ENST0000030249549383_474333477.0DomainPDZ
TgeneHTRA4chr8:37727938chr8:38836734ENST0000030249539383_474322477.0DomainPDZ
TgeneHTRA4chr8:37727938chr8:38839172ENST0000030249549383_474333477.0DomainPDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-45556_609577650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-45556_609577650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-45556_609577650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-45556_609577650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-451211_1273577650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-561211_127312111284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-131_1260440.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-451211_1273577650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-561211_127312111284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-131_1260440.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-451211_1273577650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-561211_127312111284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-131_1260440.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-451211_1273577650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-561211_127312111284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-131_1260440.0DomainC2
TgeneHTRA4chr8:37727937chr8:38836733ENST000003024953936_99322477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727937chr8:38836733ENST000003024953988_154322477.0DomainKazal-like
TgeneHTRA4chr8:37727937chr8:38839171ENST000003024954936_99333477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727937chr8:38839171ENST000003024954988_154333477.0DomainKazal-like
TgeneHTRA4chr8:37727938chr8:38836734ENST000003024953936_99322477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727938chr8:38836734ENST000003024953988_154322477.0DomainKazal-like
TgeneHTRA4chr8:37727938chr8:38839172ENST000003024954936_99333477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727938chr8:38839172ENST000003024954988_154333477.0DomainKazal-like
TgeneHTRA4chr8:37727937chr8:38836733ENST0000030249539202_362322477.0RegionNote=Serine protease
TgeneHTRA4chr8:37727937chr8:38839171ENST0000030249549202_362333477.0RegionNote=Serine protease
TgeneHTRA4chr8:37727938chr8:38836734ENST0000030249539202_362322477.0RegionNote=Serine protease
TgeneHTRA4chr8:37727938chr8:38839172ENST0000030249549202_362333477.0RegionNote=Serine protease


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Fusion Gene Sequence for RAB11FIP1-HTRA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71138_71138_1_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000287263_HTRA4_chr8_38836733_ENST00000302495_length(transcript)=2786nt_BP=1757nt
CTCGCTTCTGGAGTGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGG
TGACGGTGCTGCAGGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGT
ACGCCACCTCCGTGTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGAC
CCGCGGCCGCCGCCACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGC
GGGATCTGCACCGCGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAA
TTGAGGTTGACATCCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAA
AGCTGAAGGACAAGATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACA
GTGATGATGAGTCTGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTT
CCCAGTCCATGTCTGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACA
ATGAGGATGAGTCCTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTA
CCCTTCCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGA
ACCATGTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGA
AGCATTTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCT
CCGAATCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACA
TGGCCCCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGG
GGAAGAAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGC
CGGGGGAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCC
TGAACCTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGG
CTCCCCAGACCAGAGCTGTCAAGCCCCGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAA
CTGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGTATGGGAATTCTGGTGGTCCTCTGGTGAACTTGGATGGTGATG
TGATTGGCGTCAATTCATTGAGGGTGACTGATGGAATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATG
AGCACCAGATGAAAGGAAAGGCGTTTTCAAATAAGAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGA
AAATGCATTATCCAGATTTCCCTGATGTGAGTTCTGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGA
GAGATCACGATGTAATTGTCAACATAAATGGGAAACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCA
TGGCTGTTCTTCGGGGAAAAGATAATTTGCTCCTGACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTA
AAAAAAAAAAAACCAGTTATATCACGTGGTTTGTATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAA
AATGGATGGTTATCAACCCAAATGCCCATCAATGACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCAT
AAAAAGCAACAGTCCTCTGCAGGGACATGGATGGAGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGC
ATGTTCTCACTTATAAGTGGGAGCTGAACAATGAGAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGG
GTAGAGGGAGGGAGAGCATTAGCAAAAATAGCTAATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCA

>71138_71138_1_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000287263_HTRA4_chr8_38836733_ENST00000302495_length(amino acids)=731AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAF
SNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDN

--------------------------------------------------------------
>71138_71138_2_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000287263_HTRA4_chr8_38839171_ENST00000302495_length(transcript)=2753nt_BP=1757nt
CTCGCTTCTGGAGTGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGG
TGACGGTGCTGCAGGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGT
ACGCCACCTCCGTGTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGAC
CCGCGGCCGCCGCCACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGC
GGGATCTGCACCGCGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAA
TTGAGGTTGACATCCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAA
AGCTGAAGGACAAGATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACA
GTGATGATGAGTCTGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTT
CCCAGTCCATGTCTGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACA
ATGAGGATGAGTCCTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTA
CCCTTCCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGA
ACCATGTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGA
AGCATTTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCT
CCGAATCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACA
TGGCCCCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGG
GGAAGAAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGC
CGGGGGAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCC
TGAACCTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGG
CTCCCCAGACCAGAGCTGTCAAGCCCCGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAA
CTGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGGATGGTGATGTGATTGGCGTCAATTCATTGAGGGTGACTGATG
GAATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATGAGCACCAGATGAAAGGAAAGGCGTTTTCAAATA
AGAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGAAAATGCATTATCCAGATTTCCCTGATGTGAGTT
CTGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGAGAGATCACGATGTAATTGTCAACATAAATGGGA
AACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCATGGCTGTTCTTCGGGGAAAAGATAATTTGCTCC
TGACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTAAAAAAAAAAAAACCAGTTATATCACGTGGTTTG
TATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAAAATGGATGGTTATCAACCCAAATGCCCATCAAT
GACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCATAAAAAGCAACAGTCCTCTGCAGGGACATGGATG
GAGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGCATGTTCTCACTTATAAGTGGGAGCTGAACAATG
AGAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGGGTAGAGGGAGGGAGAGCATTAGCAAAAATAGCT
AATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCATCATGGCACACATTTACCTATGAAACAAACCTG

>71138_71138_2_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000287263_HTRA4_chr8_38839171_ENST00000302495_length(amino acids)=720AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQML
SLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN

--------------------------------------------------------------
>71138_71138_3_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000330843_HTRA4_chr8_38836733_ENST00000302495_length(transcript)=4675nt_BP=3646nt
TGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGGTGACGGTGCTGCA
GGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGTACGCCACCTCCGT
GTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGACCCGCGGCCGCCGC
CACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGCGGGATCTGCACCG
CGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAATTGAGGTTGACAT
CCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAAAGCTGAAGGACAA
GATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACAGTGATGATGAGTC
TGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGTC
TGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACAATGAGGATGAGTC
CTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCTTCCCAAGAA
GGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCATGTTTACCT
GGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCATTTGTTCTC
TTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGAATCTTCCAC
CAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGCCCCCGCAAA
CTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAAGAAGGATGT
GGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGGGGAGGACGC
ATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAACCTCTTTGA
AGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCCCCAGACCAG
AGCTGTCAAGCCCCGACTGGAAGTGTCTCCAGAGGCGCAACCCACAGCCAGGCTTCCTTCCCCTACTGACTCCCCTTCCTCTCTTCCTCC
TCTTCCTTCTAGCTCTGGCCAGGCATCTGTCCCCTCTGAATTGGGACATGGTGCAGACACACAGTCCTCTGAGAGTCCTTCTGTCTTCTC
CTCTCTCTCATCTCCCATAGCAGCTCCCATTTCCACATCCACTCCAATTGAAAGCTGGCCTCTCGTAGACAGGGGCCAGGCCAAGTCTGA
AGGACCACCCTTGCTCCCTAAGGCAGAGTTGCAAACTGAGAGTTTAACACCGGTTCCAAATTCTGGTTCTTCTGCCCTGGGATCACTTTT
CAAACAGCCATCCTTTCCAGCAAATAAAGGGACAGAAGATTCTCTGATGGGCAGGACCCGTGAGACAGGCACAGAGAAGAACACCAGCAG
CCTTGAGTTGGAGGAGTCTCTCCCAGAGCAGCCTGAAACAGGGCGACAAGAGGAAGAACTTCCGAGATTCCCCTGCAAAAAACAAGACTA
CAGCCCATCATCTGGAGAAGCCCAGGAAGTACCGTTTGCCCTTTCACTCAGCAGTGATGGAGCTGTGAGCCCTGTTGGGGAGCTTGCAGC
AGGAGGAGACAGAGACTTGGAGAGTCAGGCTGGGTCTCTTGTGGAGAGCAAAGCCAGGGATGCAGCTGAAGAAGTGGCGCCCCCTCTTCC
CATGGGAGCATCAGTCCCTTCCATTGATTCCATGATGCGGAAGCTGGAAGAGATGGGTCTGAACCTCCGCAAGGACCAGAAGAAAACCAA
GAAGCGTGTGTCATTTTCTGAGCAGCTCTTCACGGAAGAGGCAGTGGCGGGGGCTGCCTTGCTGGTGGAAGGACACAGCAGTTGTCCCCA
GGAGCTGAACCCTGCATGGTCTGTTGCTGGAAACGCGTCTGACGGAGAGCCTCCTGAGTCTCCCCACGCAGAGGACTCAGAAAGGGAATC
GGTGACCACACCTGGGCCAGCGACGTGTGGTGCGCCAGCCTCCCCAGCGGATCACCTCCTCCTCCCCTCCCAGGAGGAGAGTTTCTCCGA
AGTCCCCATGAGTGAAGCAAGCTCAGCGAAAGACACTCCACTCTTTAGGATGGAGGGAGAGGATGCCCTTGTGACTCAGTATCAGAGCAA
AGCCAGTGACCACGAAGGTTTATTGTCTGACCCCTTGAGTGACCTTCAGTTGGTCTCAGATTTTAAATCTCCAATCATGGCCGATCTGAA
CTTAAGCCTTCCTTCCATTCCTGAAGTCGCATCGGATGATGAAAGAATAGATCAGGTTGAAGATGACGGAGATCAGGTTGAAGATGATGG
AGAGACAGCAAAGTCGTCAACTCTGGACATAGGAGCTTTGTCCTTGGGCTTGGTAGTCCCCTGTCCTGAGAGGGGAAAGGGGCCCAGTGG
CGAGGCAGATAGGTTGGTACTGGGGGAGGGCCTGTGTGATTTCAGGCTGCAAGCACCCCAGGCATCTGTGACAGCTCCTTCAGAGCAGAC
CACAGAGTTCGGAATTCACAAACCACATCTTGGCAAGAGCTCAAGCTTGGATAAACAGCTGCCAGGCCCCAGTGGTGGTGAGGAAGAAAA
ACCGATGGGAAATGGGAGTCCAAGCCCGCCTCCTGGCACATCCCTGGACAATCCTGTACCCAGCCCCTCCCCTTCTGAGATCTTTCCTGT
CACACACTCTTTCCCCAGCTCTGCACATTCTGACACTCACCACACCAGCACAGCAGAATCTCAAAAAAAAGCCACAGCAGAGGGCTCCGC
TGGTAGAGTTGAAAATTTTGGCAAGAGGAAGCCACTCCTCCAGGCCTGGGTCTCACCCTCGGAGACACATCCAGTCTCAGCTCAGCCAGG
CGCTGGAACTGGGTCAGCCAAGCACAGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAAC
TGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGTATGGGAATTCTGGTGGTCCTCTGGTGAACTTGGATGGTGATGT
GATTGGCGTCAATTCATTGAGGGTGACTGATGGAATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATGA
GCACCAGATGAAAGGAAAGGCGTTTTCAAATAAGAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGAA
AATGCATTATCCAGATTTCCCTGATGTGAGTTCTGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGAG
AGATCACGATGTAATTGTCAACATAAATGGGAAACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCAT
GGCTGTTCTTCGGGGAAAAGATAATTTGCTCCTGACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTAA
AAAAAAAAAAACCAGTTATATCACGTGGTTTGTATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAAA
ATGGATGGTTATCAACCCAAATGCCCATCAATGACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCATA
AAAAGCAACAGTCCTCTGCAGGGACATGGATGGAGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGCA
TGTTCTCACTTATAAGTGGGAGCTGAACAATGAGAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGGG
TAGAGGGAGGGAGAGCATTAGCAAAAATAGCTAATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCAT

>71138_71138_3_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000330843_HTRA4_chr8_38836733_ENST00000302495_length(amino acids)=1365AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMK
GKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLR

--------------------------------------------------------------
>71138_71138_4_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000330843_HTRA4_chr8_38839171_ENST00000302495_length(transcript)=4642nt_BP=3646nt
TGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGGTGACGGTGCTGCA
GGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGTACGCCACCTCCGT
GTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGACCCGCGGCCGCCGC
CACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGCGGGATCTGCACCG
CGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAATTGAGGTTGACAT
CCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAAAGCTGAAGGACAA
GATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACAGTGATGATGAGTC
TGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGTC
TGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACAATGAGGATGAGTC
CTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCTTCCCAAGAA
GGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCATGTTTACCT
GGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCATTTGTTCTC
TTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGAATCTTCCAC
CAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGCCCCCGCAAA
CTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAAGAAGGATGT
GGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGGGGAGGACGC
ATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAACCTCTTTGA
AGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCCCCAGACCAG
AGCTGTCAAGCCCCGACTGGAAGTGTCTCCAGAGGCGCAACCCACAGCCAGGCTTCCTTCCCCTACTGACTCCCCTTCCTCTCTTCCTCC
TCTTCCTTCTAGCTCTGGCCAGGCATCTGTCCCCTCTGAATTGGGACATGGTGCAGACACACAGTCCTCTGAGAGTCCTTCTGTCTTCTC
CTCTCTCTCATCTCCCATAGCAGCTCCCATTTCCACATCCACTCCAATTGAAAGCTGGCCTCTCGTAGACAGGGGCCAGGCCAAGTCTGA
AGGACCACCCTTGCTCCCTAAGGCAGAGTTGCAAACTGAGAGTTTAACACCGGTTCCAAATTCTGGTTCTTCTGCCCTGGGATCACTTTT
CAAACAGCCATCCTTTCCAGCAAATAAAGGGACAGAAGATTCTCTGATGGGCAGGACCCGTGAGACAGGCACAGAGAAGAACACCAGCAG
CCTTGAGTTGGAGGAGTCTCTCCCAGAGCAGCCTGAAACAGGGCGACAAGAGGAAGAACTTCCGAGATTCCCCTGCAAAAAACAAGACTA
CAGCCCATCATCTGGAGAAGCCCAGGAAGTACCGTTTGCCCTTTCACTCAGCAGTGATGGAGCTGTGAGCCCTGTTGGGGAGCTTGCAGC
AGGAGGAGACAGAGACTTGGAGAGTCAGGCTGGGTCTCTTGTGGAGAGCAAAGCCAGGGATGCAGCTGAAGAAGTGGCGCCCCCTCTTCC
CATGGGAGCATCAGTCCCTTCCATTGATTCCATGATGCGGAAGCTGGAAGAGATGGGTCTGAACCTCCGCAAGGACCAGAAGAAAACCAA
GAAGCGTGTGTCATTTTCTGAGCAGCTCTTCACGGAAGAGGCAGTGGCGGGGGCTGCCTTGCTGGTGGAAGGACACAGCAGTTGTCCCCA
GGAGCTGAACCCTGCATGGTCTGTTGCTGGAAACGCGTCTGACGGAGAGCCTCCTGAGTCTCCCCACGCAGAGGACTCAGAAAGGGAATC
GGTGACCACACCTGGGCCAGCGACGTGTGGTGCGCCAGCCTCCCCAGCGGATCACCTCCTCCTCCCCTCCCAGGAGGAGAGTTTCTCCGA
AGTCCCCATGAGTGAAGCAAGCTCAGCGAAAGACACTCCACTCTTTAGGATGGAGGGAGAGGATGCCCTTGTGACTCAGTATCAGAGCAA
AGCCAGTGACCACGAAGGTTTATTGTCTGACCCCTTGAGTGACCTTCAGTTGGTCTCAGATTTTAAATCTCCAATCATGGCCGATCTGAA
CTTAAGCCTTCCTTCCATTCCTGAAGTCGCATCGGATGATGAAAGAATAGATCAGGTTGAAGATGACGGAGATCAGGTTGAAGATGATGG
AGAGACAGCAAAGTCGTCAACTCTGGACATAGGAGCTTTGTCCTTGGGCTTGGTAGTCCCCTGTCCTGAGAGGGGAAAGGGGCCCAGTGG
CGAGGCAGATAGGTTGGTACTGGGGGAGGGCCTGTGTGATTTCAGGCTGCAAGCACCCCAGGCATCTGTGACAGCTCCTTCAGAGCAGAC
CACAGAGTTCGGAATTCACAAACCACATCTTGGCAAGAGCTCAAGCTTGGATAAACAGCTGCCAGGCCCCAGTGGTGGTGAGGAAGAAAA
ACCGATGGGAAATGGGAGTCCAAGCCCGCCTCCTGGCACATCCCTGGACAATCCTGTACCCAGCCCCTCCCCTTCTGAGATCTTTCCTGT
CACACACTCTTTCCCCAGCTCTGCACATTCTGACACTCACCACACCAGCACAGCAGAATCTCAAAAAAAAGCCACAGCAGAGGGCTCCGC
TGGTAGAGTTGAAAATTTTGGCAAGAGGAAGCCACTCCTCCAGGCCTGGGTCTCACCCTCGGAGACACATCCAGTCTCAGCTCAGCCAGG
CGCTGGAACTGGGTCAGCCAAGCACAGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAAC
TGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGGATGGTGATGTGATTGGCGTCAATTCATTGAGGGTGACTGATGG
AATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATGAGCACCAGATGAAAGGAAAGGCGTTTTCAAATAA
GAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGAAAATGCATTATCCAGATTTCCCTGATGTGAGTTC
TGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGAGAGATCACGATGTAATTGTCAACATAAATGGGAA
ACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCATGGCTGTTCTTCGGGGAAAAGATAATTTGCTCCT
GACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTAAAAAAAAAAAAACCAGTTATATCACGTGGTTTGT
ATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAAAATGGATGGTTATCAACCCAAATGCCCATCAATG
ACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCATAAAAAGCAACAGTCCTCTGCAGGGACATGGATGG
AGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGCATGTTCTCACTTATAAGTGGGAGCTGAACAATGA
GAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGGGTAGAGGGAGGGAGAGCATTAGCAAAAATAGCTA
ATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCATCATGGCACACATTTACCTATGAAACAAACCTGC

>71138_71138_4_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000330843_HTRA4_chr8_38839171_ENST00000302495_length(amino acids)=1354AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLG
LQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIP

--------------------------------------------------------------
>71138_71138_5_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000287263_HTRA4_chr8_38836734_ENST00000302495_length(transcript)=2786nt_BP=1757nt
CTCGCTTCTGGAGTGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGG
TGACGGTGCTGCAGGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGT
ACGCCACCTCCGTGTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGAC
CCGCGGCCGCCGCCACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGC
GGGATCTGCACCGCGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAA
TTGAGGTTGACATCCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAA
AGCTGAAGGACAAGATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACA
GTGATGATGAGTCTGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTT
CCCAGTCCATGTCTGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACA
ATGAGGATGAGTCCTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTA
CCCTTCCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGA
ACCATGTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGA
AGCATTTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCT
CCGAATCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACA
TGGCCCCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGG
GGAAGAAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGC
CGGGGGAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCC
TGAACCTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGG
CTCCCCAGACCAGAGCTGTCAAGCCCCGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAA
CTGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGTATGGGAATTCTGGTGGTCCTCTGGTGAACTTGGATGGTGATG
TGATTGGCGTCAATTCATTGAGGGTGACTGATGGAATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATG
AGCACCAGATGAAAGGAAAGGCGTTTTCAAATAAGAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGA
AAATGCATTATCCAGATTTCCCTGATGTGAGTTCTGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGA
GAGATCACGATGTAATTGTCAACATAAATGGGAAACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCA
TGGCTGTTCTTCGGGGAAAAGATAATTTGCTCCTGACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTA
AAAAAAAAAAAACCAGTTATATCACGTGGTTTGTATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAA
AATGGATGGTTATCAACCCAAATGCCCATCAATGACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCAT
AAAAAGCAACAGTCCTCTGCAGGGACATGGATGGAGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGC
ATGTTCTCACTTATAAGTGGGAGCTGAACAATGAGAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGG
GTAGAGGGAGGGAGAGCATTAGCAAAAATAGCTAATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCA

>71138_71138_5_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000287263_HTRA4_chr8_38836734_ENST00000302495_length(amino acids)=731AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAF
SNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDN

--------------------------------------------------------------
>71138_71138_6_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000287263_HTRA4_chr8_38839172_ENST00000302495_length(transcript)=2753nt_BP=1757nt
CTCGCTTCTGGAGTGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGG
TGACGGTGCTGCAGGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGT
ACGCCACCTCCGTGTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGAC
CCGCGGCCGCCGCCACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGC
GGGATCTGCACCGCGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAA
TTGAGGTTGACATCCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAA
AGCTGAAGGACAAGATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACA
GTGATGATGAGTCTGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTT
CCCAGTCCATGTCTGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACA
ATGAGGATGAGTCCTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTA
CCCTTCCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGA
ACCATGTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGA
AGCATTTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCT
CCGAATCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACA
TGGCCCCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGG
GGAAGAAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGC
CGGGGGAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCC
TGAACCTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGG
CTCCCCAGACCAGAGCTGTCAAGCCCCGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAA
CTGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGGATGGTGATGTGATTGGCGTCAATTCATTGAGGGTGACTGATG
GAATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATGAGCACCAGATGAAAGGAAAGGCGTTTTCAAATA
AGAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGAAAATGCATTATCCAGATTTCCCTGATGTGAGTT
CTGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGAGAGATCACGATGTAATTGTCAACATAAATGGGA
AACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCATGGCTGTTCTTCGGGGAAAAGATAATTTGCTCC
TGACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTAAAAAAAAAAAAACCAGTTATATCACGTGGTTTG
TATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAAAATGGATGGTTATCAACCCAAATGCCCATCAAT
GACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCATAAAAAGCAACAGTCCTCTGCAGGGACATGGATG
GAGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGCATGTTCTCACTTATAAGTGGGAGCTGAACAATG
AGAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGGGTAGAGGGAGGGAGAGCATTAGCAAAAATAGCT
AATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCATCATGGCACACATTTACCTATGAAACAAACCTG

>71138_71138_6_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000287263_HTRA4_chr8_38839172_ENST00000302495_length(amino acids)=720AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQML
SLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN

--------------------------------------------------------------
>71138_71138_7_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000330843_HTRA4_chr8_38836734_ENST00000302495_length(transcript)=4675nt_BP=3646nt
TGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGGTGACGGTGCTGCA
GGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGTACGCCACCTCCGT
GTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGACCCGCGGCCGCCGC
CACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGCGGGATCTGCACCG
CGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAATTGAGGTTGACAT
CCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAAAGCTGAAGGACAA
GATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACAGTGATGATGAGTC
TGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGTC
TGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACAATGAGGATGAGTC
CTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCTTCCCAAGAA
GGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCATGTTTACCT
GGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCATTTGTTCTC
TTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGAATCTTCCAC
CAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGCCCCCGCAAA
CTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAAGAAGGATGT
GGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGGGGAGGACGC
ATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAACCTCTTTGA
AGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCCCCAGACCAG
AGCTGTCAAGCCCCGACTGGAAGTGTCTCCAGAGGCGCAACCCACAGCCAGGCTTCCTTCCCCTACTGACTCCCCTTCCTCTCTTCCTCC
TCTTCCTTCTAGCTCTGGCCAGGCATCTGTCCCCTCTGAATTGGGACATGGTGCAGACACACAGTCCTCTGAGAGTCCTTCTGTCTTCTC
CTCTCTCTCATCTCCCATAGCAGCTCCCATTTCCACATCCACTCCAATTGAAAGCTGGCCTCTCGTAGACAGGGGCCAGGCCAAGTCTGA
AGGACCACCCTTGCTCCCTAAGGCAGAGTTGCAAACTGAGAGTTTAACACCGGTTCCAAATTCTGGTTCTTCTGCCCTGGGATCACTTTT
CAAACAGCCATCCTTTCCAGCAAATAAAGGGACAGAAGATTCTCTGATGGGCAGGACCCGTGAGACAGGCACAGAGAAGAACACCAGCAG
CCTTGAGTTGGAGGAGTCTCTCCCAGAGCAGCCTGAAACAGGGCGACAAGAGGAAGAACTTCCGAGATTCCCCTGCAAAAAACAAGACTA
CAGCCCATCATCTGGAGAAGCCCAGGAAGTACCGTTTGCCCTTTCACTCAGCAGTGATGGAGCTGTGAGCCCTGTTGGGGAGCTTGCAGC
AGGAGGAGACAGAGACTTGGAGAGTCAGGCTGGGTCTCTTGTGGAGAGCAAAGCCAGGGATGCAGCTGAAGAAGTGGCGCCCCCTCTTCC
CATGGGAGCATCAGTCCCTTCCATTGATTCCATGATGCGGAAGCTGGAAGAGATGGGTCTGAACCTCCGCAAGGACCAGAAGAAAACCAA
GAAGCGTGTGTCATTTTCTGAGCAGCTCTTCACGGAAGAGGCAGTGGCGGGGGCTGCCTTGCTGGTGGAAGGACACAGCAGTTGTCCCCA
GGAGCTGAACCCTGCATGGTCTGTTGCTGGAAACGCGTCTGACGGAGAGCCTCCTGAGTCTCCCCACGCAGAGGACTCAGAAAGGGAATC
GGTGACCACACCTGGGCCAGCGACGTGTGGTGCGCCAGCCTCCCCAGCGGATCACCTCCTCCTCCCCTCCCAGGAGGAGAGTTTCTCCGA
AGTCCCCATGAGTGAAGCAAGCTCAGCGAAAGACACTCCACTCTTTAGGATGGAGGGAGAGGATGCCCTTGTGACTCAGTATCAGAGCAA
AGCCAGTGACCACGAAGGTTTATTGTCTGACCCCTTGAGTGACCTTCAGTTGGTCTCAGATTTTAAATCTCCAATCATGGCCGATCTGAA
CTTAAGCCTTCCTTCCATTCCTGAAGTCGCATCGGATGATGAAAGAATAGATCAGGTTGAAGATGACGGAGATCAGGTTGAAGATGATGG
AGAGACAGCAAAGTCGTCAACTCTGGACATAGGAGCTTTGTCCTTGGGCTTGGTAGTCCCCTGTCCTGAGAGGGGAAAGGGGCCCAGTGG
CGAGGCAGATAGGTTGGTACTGGGGGAGGGCCTGTGTGATTTCAGGCTGCAAGCACCCCAGGCATCTGTGACAGCTCCTTCAGAGCAGAC
CACAGAGTTCGGAATTCACAAACCACATCTTGGCAAGAGCTCAAGCTTGGATAAACAGCTGCCAGGCCCCAGTGGTGGTGAGGAAGAAAA
ACCGATGGGAAATGGGAGTCCAAGCCCGCCTCCTGGCACATCCCTGGACAATCCTGTACCCAGCCCCTCCCCTTCTGAGATCTTTCCTGT
CACACACTCTTTCCCCAGCTCTGCACATTCTGACACTCACCACACCAGCACAGCAGAATCTCAAAAAAAAGCCACAGCAGAGGGCTCCGC
TGGTAGAGTTGAAAATTTTGGCAAGAGGAAGCCACTCCTCCAGGCCTGGGTCTCACCCTCGGAGACACATCCAGTCTCAGCTCAGCCAGG
CGCTGGAACTGGGTCAGCCAAGCACAGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAAC
TGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGTATGGGAATTCTGGTGGTCCTCTGGTGAACTTGGATGGTGATGT
GATTGGCGTCAATTCATTGAGGGTGACTGATGGAATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATGA
GCACCAGATGAAAGGAAAGGCGTTTTCAAATAAGAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGAA
AATGCATTATCCAGATTTCCCTGATGTGAGTTCTGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGAG
AGATCACGATGTAATTGTCAACATAAATGGGAAACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCAT
GGCTGTTCTTCGGGGAAAAGATAATTTGCTCCTGACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTAA
AAAAAAAAAAACCAGTTATATCACGTGGTTTGTATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAAA
ATGGATGGTTATCAACCCAAATGCCCATCAATGACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCATA
AAAAGCAACAGTCCTCTGCAGGGACATGGATGGAGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGCA
TGTTCTCACTTATAAGTGGGAGCTGAACAATGAGAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGGG
TAGAGGGAGGGAGAGCATTAGCAAAAATAGCTAATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCAT

>71138_71138_7_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000330843_HTRA4_chr8_38836734_ENST00000302495_length(amino acids)=1365AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMK
GKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLR

--------------------------------------------------------------
>71138_71138_8_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000330843_HTRA4_chr8_38839172_ENST00000302495_length(transcript)=4642nt_BP=3646nt
TGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGGTGACGGTGCTGCA
GGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGTACGCCACCTCCGT
GTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGACCCGCGGCCGCCGC
CACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGCGGGATCTGCACCG
CGACCAGGGCCGCAGGAAGACGCAGTGGTATAAGTTGAAATCCAAACCAGGAAAGAAGGACAAGGAGCGAGGAGAAATTGAGGTTGACAT
CCAGTTTATGAGAAACAACATGACTGCCAGCATGTTTGACCTTTCTATGAAAGACAAGTCTCGGAATCCATTTGGAAAGCTGAAGGACAA
GATCAAGGGGAAGAATAAGGACAGTGGGTCAGACACCGCCTCCGCCATCATCCCTAGCACGACACCTTCGGTCGACAGTGATGATGAGTC
TGTGGTTAAAGACAAGAAAAAGAAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGTC
TGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACAATGAGGATGAGTC
CTCCTCGGCCTCGGATGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCTTCCCAAGAA
GGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCATGTTTACCT
GGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCATTTGTTCTC
TTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGAATCTTCCAC
CAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGCCCCCGCAAA
CTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAAGAAGGATGT
GGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGGGGAGGACGC
ATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAACCTCTTTGA
AGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCCCCAGACCAG
AGCTGTCAAGCCCCGACTGGAAGTGTCTCCAGAGGCGCAACCCACAGCCAGGCTTCCTTCCCCTACTGACTCCCCTTCCTCTCTTCCTCC
TCTTCCTTCTAGCTCTGGCCAGGCATCTGTCCCCTCTGAATTGGGACATGGTGCAGACACACAGTCCTCTGAGAGTCCTTCTGTCTTCTC
CTCTCTCTCATCTCCCATAGCAGCTCCCATTTCCACATCCACTCCAATTGAAAGCTGGCCTCTCGTAGACAGGGGCCAGGCCAAGTCTGA
AGGACCACCCTTGCTCCCTAAGGCAGAGTTGCAAACTGAGAGTTTAACACCGGTTCCAAATTCTGGTTCTTCTGCCCTGGGATCACTTTT
CAAACAGCCATCCTTTCCAGCAAATAAAGGGACAGAAGATTCTCTGATGGGCAGGACCCGTGAGACAGGCACAGAGAAGAACACCAGCAG
CCTTGAGTTGGAGGAGTCTCTCCCAGAGCAGCCTGAAACAGGGCGACAAGAGGAAGAACTTCCGAGATTCCCCTGCAAAAAACAAGACTA
CAGCCCATCATCTGGAGAAGCCCAGGAAGTACCGTTTGCCCTTTCACTCAGCAGTGATGGAGCTGTGAGCCCTGTTGGGGAGCTTGCAGC
AGGAGGAGACAGAGACTTGGAGAGTCAGGCTGGGTCTCTTGTGGAGAGCAAAGCCAGGGATGCAGCTGAAGAAGTGGCGCCCCCTCTTCC
CATGGGAGCATCAGTCCCTTCCATTGATTCCATGATGCGGAAGCTGGAAGAGATGGGTCTGAACCTCCGCAAGGACCAGAAGAAAACCAA
GAAGCGTGTGTCATTTTCTGAGCAGCTCTTCACGGAAGAGGCAGTGGCGGGGGCTGCCTTGCTGGTGGAAGGACACAGCAGTTGTCCCCA
GGAGCTGAACCCTGCATGGTCTGTTGCTGGAAACGCGTCTGACGGAGAGCCTCCTGAGTCTCCCCACGCAGAGGACTCAGAAAGGGAATC
GGTGACCACACCTGGGCCAGCGACGTGTGGTGCGCCAGCCTCCCCAGCGGATCACCTCCTCCTCCCCTCCCAGGAGGAGAGTTTCTCCGA
AGTCCCCATGAGTGAAGCAAGCTCAGCGAAAGACACTCCACTCTTTAGGATGGAGGGAGAGGATGCCCTTGTGACTCAGTATCAGAGCAA
AGCCAGTGACCACGAAGGTTTATTGTCTGACCCCTTGAGTGACCTTCAGTTGGTCTCAGATTTTAAATCTCCAATCATGGCCGATCTGAA
CTTAAGCCTTCCTTCCATTCCTGAAGTCGCATCGGATGATGAAAGAATAGATCAGGTTGAAGATGACGGAGATCAGGTTGAAGATGATGG
AGAGACAGCAAAGTCGTCAACTCTGGACATAGGAGCTTTGTCCTTGGGCTTGGTAGTCCCCTGTCCTGAGAGGGGAAAGGGGCCCAGTGG
CGAGGCAGATAGGTTGGTACTGGGGGAGGGCCTGTGTGATTTCAGGCTGCAAGCACCCCAGGCATCTGTGACAGCTCCTTCAGAGCAGAC
CACAGAGTTCGGAATTCACAAACCACATCTTGGCAAGAGCTCAAGCTTGGATAAACAGCTGCCAGGCCCCAGTGGTGGTGAGGAAGAAAA
ACCGATGGGAAATGGGAGTCCAAGCCCGCCTCCTGGCACATCCCTGGACAATCCTGTACCCAGCCCCTCCCCTTCTGAGATCTTTCCTGT
CACACACTCTTTCCCCAGCTCTGCACATTCTGACACTCACCACACCAGCACAGCAGAATCTCAAAAAAAAGCCACAGCAGAGGGCTCCGC
TGGTAGAGTTGAAAATTTTGGCAAGAGGAAGCCACTCCTCCAGGCCTGGGTCTCACCCTCGGAGACACATCCAGTCTCAGCTCAGCCAGG
CGCTGGAACTGGGTCAGCCAAGCACAGACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAAC
TGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGGATGGTGATGTGATTGGCGTCAATTCATTGAGGGTGACTGATGG
AATCTCCTTTGCAATTCCTTCAGATCGAGTTAGGCAGTTCTTGGCAGAATACCATGAGCACCAGATGAAAGGAAAGGCGTTTTCAAATAA
GAAATATCTGGGTCTGCAAATGCTGTCCCTCACTGTGCCCCTTAGTGAAGAATTGAAAATGCATTATCCAGATTTCCCTGATGTGAGTTC
TGGGGTTTATGTATGTAAAGTGGTTGAAGGAACAGCTGCTCAAAGCTCTGGATTGAGAGATCACGATGTAATTGTCAACATAAATGGGAA
ACCTATTACTACTACAACTGATGTTGTTAAAGCTCTTGACAGTGATTCCCTTTCCATGGCTGTTCTTCGGGGAAAAGATAATTTGCTCCT
GACAGTCATACCTGAAACAATCAATTAAATATCTTGTTTTAAAGTGGGATTATCTAAAAAAAAAAAAACCAGTTATATCACGTGGTTTGT
ATTGGAGATGTGCCAAACATGGCAAGAAGTTTTTGGATCTTTTTCTTACAAAGAAAAATGGATGGTTATCAACCCAAATGCCCATCAATG
ACAGACTGGATAAAGCAAATGTGGTACATATACACCATGGAATACTATGCAGCCATAAAAAGCAACAGTCCTCTGCAGGGACATGGATGG
AGCTGGAAACCATTATCCTCAGCAAACTAACGCAGGAACAGAAAACCAAATACTGCATGTTCTCACTTATAAGTGGGAGCTGAACAATGA
GAACACATGAACATAGGGAGGGGAACAACACACACTGGGGCCTGGCAGTGGGTAGGGTAGAGGGAGGGAGAGCATTAGCAAAAATAGCTA
ATGCATGCTGGGCTTAACACCCAGGTGATGGGTTGATTGATAGGTGCAGCAAACCATCATGGCACACATTTACCTATGAAACAAACCTGC

>71138_71138_8_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000330843_HTRA4_chr8_38839172_ENST00000302495_length(amino acids)=1354AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLG
LQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIP

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Fusion Gene PPI Analysis for RAB11FIP1-HTRA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB11FIP1-HTRA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB11FIP1-HTRA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource