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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB3GAP1-STK35 (FusionGDB2 ID:71363)

Fusion Gene Summary for RAB3GAP1-STK35

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB3GAP1-STK35
Fusion gene ID: 71363
HgeneTgene
Gene symbol

RAB3GAP1

STK35

Gene ID

22930

140901

Gene nameRAB3 GTPase activating protein catalytic subunit 1serine/threonine kinase 35
SynonymsP130|RAB3GAP|RAB3GAP130|WARBM1CLIK1|STK35L1
Cytomap

2q21.3

20p13

Type of geneprotein-codingprotein-coding
Descriptionrab3 GTPase-activating protein catalytic subunitRAB3 GTPase activating protein subunit 1 (catalytic)RAB3 GTPase-activating protein 130 kDa subunitrab3-GAP p130serine/threonine-protein kinase 35CLIK-1CLP-36 interacting kinaseCLP-36-interacting kinase 1PDLIM1-interacting kinase 1serine threonine kinase 35 long formserine/threonine-protein kinase 35 L1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264158, ENST00000425393, 
ENST00000442034, ENST00000539493, 
ENST00000487003, 		ENST00000246032, 
ENST00000400064, ENST00000381482, 
Fusion gene scores* DoF score13 X 11 X 9=12872 X 2 X 2=8
# samples 172
** MAII scorelog2(17/1287*10)=-2.920405402083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: RAB3GAP1 [Title/Abstract] AND STK35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB3GAP1(135815656)-STK35(2083414), # samples:1
Anticipated loss of major functional domain due to fusion event.RAB3GAP1-STK35 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RAB3GAP1-STK35 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RAB3GAP1-STK35 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RAB3GAP1-STK35 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB3GAP1

GO:0043087

regulation of GTPase activity

10859313


check buttonFusion gene breakpoints across RAB3GAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STK35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8527-01ARAB3GAP1chr2

135815656

+STK35chr20

2083414

+


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Fusion Gene ORF analysis for RAB3GAP1-STK35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264158ENST00000246032RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5CDS-5UTRENST00000425393ENST00000246032RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5CDS-5UTRENST00000442034ENST00000246032RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5CDS-intronENST00000264158ENST00000400064RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5CDS-intronENST00000425393ENST00000400064RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5CDS-intronENST00000442034ENST00000400064RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5UTR-3CDSENST00000539493ENST00000381482RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5UTR-5UTRENST00000539493ENST00000246032RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
5UTR-intronENST00000539493ENST00000400064RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
Frame-shiftENST00000425393ENST00000381482RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
In-frameENST00000264158ENST00000381482RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
In-frameENST00000442034ENST00000381482RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
intron-3CDSENST00000487003ENST00000381482RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
intron-5UTRENST00000487003ENST00000246032RAB3GAP1chr2

135815656

+STK35chr20

2083414

+
intron-intronENST00000487003ENST00000400064RAB3GAP1chr2

135815656

+STK35chr20

2083414

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264158RAB3GAP1chr2135815656+ENST00000381482STK35chr202083414+6313193431503486
ENST00000442034RAB3GAP1chr2135815656+ENST00000381482STK35chr202083414+6280160101470486

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264158ENST00000381482RAB3GAP1chr2135815656+STK35chr202083414+0.0012354190.99876463
ENST00000442034ENST00000381482RAB3GAP1chr2135815656+STK35chr202083414+0.0012397450.9987602

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Fusion Genomic Features for RAB3GAP1-STK35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAB3GAP1chr2135815656+STK35chr202083413+0.58114450.4188555
RAB3GAP1chr2135815656+STK35chr202083413+0.58114450.4188555

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RAB3GAP1-STK35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:135815656/chr20:2083414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTK35chr2:135815656chr20:2083414ENST000002460320440_18701893.0Compositional biasNote=Ala-rich
TgeneSTK35chr2:135815656chr20:2083414ENST0000024603204202_53001893.0DomainProtein kinase
TgeneSTK35chr2:135815656chr20:2083414ENST0000038148204202_530981937.3333333333333DomainProtein kinase
TgeneSTK35chr2:135815656chr20:2083414ENST0000024603204208_21601893.0Nucleotide bindingATP
TgeneSTK35chr2:135815656chr20:2083414ENST0000038148204208_216981937.3333333333333Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTK35chr2:135815656chr20:2083414ENST000003814820440_187981937.3333333333333Compositional biasNote=Ala-rich


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Fusion Gene Sequence for RAB3GAP1-STK35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71363_71363_1_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000264158_STK35_chr20_2083414_ENST00000381482_length(transcript)=6313nt_BP=193nt
CTTCTTCCCGGCAGCCTTAGCGCCAGGCCCGGCGCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGA
CTTCACCACTGCCTCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAA
GCCACTCGAAAAGGTCACAATCCAAGGTCCGGCTCCTCCGCGTCCCAGGGCCGGACGGAGGGATGAGGCAGGGGGGGCCCGGGCAGCGCC
GTTGCTGCTCCCCCCGCCGCCCGCAGCCATGGAAACGGGGAAGGACGGCGCCCGCAGAGGTACACAAAGCCCGGAGCGGAAAAGGCGAAG
CCCAGTGCCGCGGGCGCCCAGCACGAAGCTGAGGCCGGCGGCGGCGGCCCGGGCCATGGATCCGGTGGCGGCCGAGGCCCCGGGCGAGGC
CTTCCTGGCGCGGCGACGGCCTGAGGGCGGTGGCGGGTCCGCGCGGCCGCGTTACAGCCTGTTGGCGGAGATCGGGCGCGGCAGCTACGG
CGTGGTTTATGAGGCAGTGGCCGGGCGCAGCGGGGCCCGGGTGGCGGTCAAGAAGATCCGCTGCGACGCCCCCGAGAACGTGGAGCTGGC
GCTGGCTGAATTCTGGGCCCTCACCAGCCTCAAGCGGCGCCACCAGAACGTCGTGCAGTTTGAGGAGTGCGTCCTGCAGCGCAATGGGTT
AGCCCAGCGCATGAGTCACGGCAACAAGAGCTCGCAGCTTTACCTGCGCCTGGTGGAGACCTCGCTGAAAGGAGAAAGGATCCTGGGTTA
TGCTGAGGAGCCCTGCTATCTCTGGTTTGTCATGGAGTTCTGTGAAGGTGGAGACCTGAATCAGTATGTCCTGTCCCGGAGGCCAGACCC
AGCCACCAACAAAAGTTTCATGCTACAGCTGACGAGCGCCATTGCCTTCCTGCACAAAAACCATATTGTGCACAGGGACCTGAAGCCAGA
CAACATCCTCATCACAGAGCGGTCTGGCACCCCCATCCTCAAAGTGGCCGACTTTGGACTAAGCAAGGTCTGTGCTGGGCTGGCACCCCG
AGGCAAAGAGGGCAATCAAGACAACAAAAATGTGAATGTGAATAAGTACTGGCTGTCCTCAGCCTGCGGTTCGGACTTCTACATGGCTCC
TGAAGTCTGGGAGGGACACTACACAGCCAAGGCGGACATCTTTGCCCTGGGCATTATCATCTGGGCAATGATAGAAAGAATCACTTTTAT
TGACTCTGAGACCAAGAAGGAGCTCCTGGGGACCTACATTAAACAGGGGACTGAGATCGTCCCTGTTGGTGAGGCGCTGCTAGAAAACCC
AAAGATGGAGTTGCACATCCCCCAAAAACGCAGGACTTCCATGTCTGAGGGGATCAAGCAGCTCTTGAAAGATATGTTAGCTGCTAACCC
ACAGGACCGGCCTGATGCCTTTGAACTTGAAACCAGAATGGACCAGGTCACATGTGCTGCTTAAAATTCAGGGCTAAGCATTTTGGGTGA
TTTTAAACTAGGTCGATTCCTCGGGACCCACAGTCTCACCACGTCTCCTCCAGAGGACGGCAGAGGGTACAGGTGGTGGCCTGGCCGGTT
GGCGATCTCCCGACAGCTGGATCCGGCAATGTGAAGCTTTTGTTTGGGTTTCCCCGCTTCTTTTTAGTTTTGCTTTATTTTTTTCCTTTT
CTTTTCTTTTTTTTTTTTCCTCTTTCCTTTTTTTAAATTTAAACCATTGAGACTTCAGAAGAGCAGGACACAATGCTGTGGACAGGCACC
AATTTCTTTAAAGAAATTCAATGTGGGCAAGGCATATGTGTAAATTTCACTTTTACTTTTTATAAGGGGTTAGGGAGCTATTTTTGGTTT
TGTCCTTCACTTTCCCTCTGTCTTCCTTCTTTATACTTTTCTCAGTTCTACTTATGACACCTCACTTCCCTAGAGAAGGCCTGCCTCCCC
ATAGGGAATCTGGGGGTTTCTTCTGGAACGGGGCGTGAGGACACAAGGAGGCCTCTGGGCCACGCCTCCCTACCAGATGCAGGAACTCCT
GGACTCCTTGGTGGGCTGGCCCTGGCTAGCCCTTGGGCCTCGGAGATGATCAGAGGTGAAGAACCGCCTGGAAGAGGAAGGCCAGGGTTT
GGCCAGGAGAACTAAGAAGGTCTCAACTCCAGGCTTTGTTGTGTTTAAGCTATTGAGAGCCCCAGGCCACACCAGGACTTGCAGTGGTGG
GAATCCATTCCTCTTCTGCCCTGTGTTGCAGGGAACTAGGAGGTAAGGGTGGAGGGCGACCATCTCGCTCTTGCTGGCGGTGGAGCAGCC
ATCCCTGCCTTTCTGTTGGGAAAAACTGTTGTGCCAAACTCTTGTGTGGAACACAGCTGGGTCTTCAGCAGGCATCTGTCACTGCCGTGA
GGTCAGCGCTTCTCACCTAACTGCCTCCTGGATTGTCATCTTCCCAGATGTGTCCCATAGTGTCCAGGTGTCACAGAGACGGCCTGAGGC
CCTAAGATCTGGTTGTGACTTTGCCATGATAACAGGGTGTCCTGAACTGGCTGCCGTTGTCGTGTTCTCACAGTGAAGGGCGTGCCCTGT
GTGCCGGGGTCCATGGTGTCATATGCAGTGACACACACTGTCAAGCGCCATTTCCCTCACCCCTGGAGACTTACTGTTAGGTGCCTGCCC
TCAGTATAGACGTATCCAATGGGAAAACAGCGGACCTGCCCAGAGCAGGGAGGTGTCGTGGAACTGGGTAGACCCCCTGCAGCGTTAGGG
GCCCATTTGTGGGCTCGCCACCTTCAGGCTTCCCCAGCCATGACACTTCAGCCCCGCCACCCATGCCTGTCTGCTGCAGCCATCCTTGCA
CTCTCCAGCGACACTCTCGCACCTCCCTAGGGGAAGCTTCCCTCCCCCTGGGCTGCTGCTCTGAGCCCATCTGTTCTCCCCCTGCAAGAA
GGGGCAATGCTCTTGTGTTGTCCCTCTGTCTGGACGCGCCTGGCCACTCCGAAGGCTTTTCACCCCATTATGGCCAAATAGTATAGGGCC
ACTGGGGAGGGGGAAGGGAATCATTTTGTGTTCATTTTTGTTTTCTGTTTCACCTAAACCAGCATAGGATTGATAGGGGAGACGGTTGGC
GGGCATTTCCGTTTCTATGTGACCAAGGCAGCAGGGGCTTTTACCTGCTAAGCGGCAATCCTTTGGCCCTGAGAATTTGGGAGAGAACAG
TGCATCAGGCCAGGCTCAGCAATATGTTTGCTCACATTCTTTCAGCCTTCTGTCACCCCCCTCAACACCAAACTTTCTTCCTTGTGAGCA
GAAGGTTGGCTGCTGTTAGCAGGATCCCACAGTGATAACCAGGCCCTTCCCTTCCTAAGCCAAAACCCATTGTGACTGCCTGTCTCTCCT
GTCTCTGACTTCTCAGGCAGCCTCCTGAGTGCACTGAGTTGTATCCGAGAGGGTGGGAACAGCAGCATCCCCTAATTGCAGTACACGGTT
CCTTTTCCGCCCGCCACCCTGCCTTTCCTTGGGGGCAGCTGTCTCTCTGTACATGAGCAAATGGGCAAAAACAGTCCCCAAACCCAGCAC
CCCCCTCTCCCTGGCTGCAGCCCACACTGTAACATCCCTAGTGAGGCTCCAGCCTAATGAGCCCCTTATTTTCTTTTTTTTCCCTCCCCA
GGTCTAGTAGCTCTAACTAAAAAGTTCTTGGAGCCATCGTGCTCCCCCTTTGTTATTTTTCTTGCTATCAGAGTAGCAAGAAACAGCACC
CCTGTAGGTGACAGGTGGGCAGCCTGGTAGGGGTCGCCAGCCTCCATGCCCCCTCATCTTCCAGTTCTTGCTTAGTGGCACGACCTCTTT
CCATAGCATAAATGCAGGCCAGCGTTTTAGCCCCAAGTGCCTGCCCTTGCTTCTTACCCCTCCCCTGCTTTCTCAAACACTTGCCCACCT
CAGGCACTCAGCGGGCTCCGCCGTGGTGAGAGAACTGGCCGTGGCTCAGCCCCGGGTAGCACCTGTAGTTTCAGTGCCACTCTCCACTGT
CCCCTTGTGGACCAGCTTCCACTCACTGTCACGTCCCCCCTCCTGCGTCTTCACTGGGTCTCAGGCTGCCAGCAGCTCTCTGGTGCATCG
TCTCAACACCACCAAGTTTGTAGGACCTGCCCAAGTTCTAGTAGTATTCAAAACTTCAAACGGCAGTCATTTGTTCTCCTCGGCTCTGTG
GCAAGGATAGCCCTTTGGAGGGGGACTCTTGACCTCGGCTGTTAGGGATCTGAACTTGGTTTTCCCGTCAGAAGAATCAGCAGGACAGAT
CGTAGTGCCTTATTCCATTGTCCTCCCCTGGCCAGGCCTCCTGGCTCAGCTGGAAGTGCATGGCTTCTTTCTCCCTATCTGTGTCCTCTG
TCACTTGCTCTTTCACTCTCTCTCTCATTCCCAGAGAGCCACGGGGGAGGGATCACCCTCACCCCCAACACCCTCTTCCTGAGGGCTGTA
GCCAGGTCCGCATCTCCCCACCACCACCAGGGCACTCACTCGCAGCTATAGCCCAGGACAGAAAAACTGTGCTTTGGACAGGTGCACACT
CTCTGCCTCTTACCTCTAGCCAGGAGGATGCCTCAGTCTGTTCATTCGAGACTGGCCCCGTCTGAACCTTCTCTGGGCACTGGGGACTAA
GGTTGCAGGCCTTAGCCTCGTCTCGTCCCAGAGGCATTGGATCAGGAGAATGGGAATTTTTTTCCTCCCACCTGGACATAGTTTGCCCCT
GTGGCTGCCTTTCTGAGGGAGTATACTAAATGTTTACTTAAGAAACACCCTGTTTACAGCCAGAGGAGAAACACCCAACACTGAGTGGAG
ATTTGACTCTGGACAGGGCCTGGCCTCCTTAGTGGCACTGCCGGGGGGCCCCAGAGCGAATGAGGGCAGAGATGCCCGGGGCAGGGGCAA
ACGCCCTCCGCTCCCTCTGCTCCCAACCCTGTGGTGCTAGGACCACTCCCCGCCTTCCCTACGGCCTCCTCGCCCTGCACATTCCCCACC
TCCACATTCCCCTCCTCCAAGATCTCAGCTCCTTAACATATCAGTTGTCTCCTAGCCTAGAAAACCAGTGTTTGGAGCAATAAGATGATT
ATTTTTGCTTGAATCTTTTTCTAAGAGAAGGAAAAGAGCTGGCATTGTGGGAATTTTCTTTTTATGCTGTTAGCTGTTTACCTTCTTAGA
AGACATCCTAATAGGATGGATGTCTGGGTTTTAGCCTTGGGGTATCTTTTGGAAACTTAGAAAAGCAGGAGTCAGGCTGCCACCCCCTAA
GGAGGGACCCTAACGTTCTGCCCTTGCCTGGTTCCATATGGCTCCTTCCAGCCCTGCCCACCAAGTGCAGCTCCCACTTTCCATCCTGCC
CATACGCCCCTCTTCCCCCGACATCTGGGGGCGCTGGTGGCACTTACTCTAGGTTGGTCTCAGACTATCCCTCCCCTTGGCTGGTTTTCC
CTCCTAGGCCTGTCTGGCAGCCCCCAGACAGACGTAGCTCCTGGGAGTCTCGGCCCTGGCAACCTTGGAAGAGCCAAGCTGACATTGTTT
AGCTCTTCAGGCCACTGGGTTTTGGAGGCAGAAGTCCAGAGATACTGGCTCTGCCAAGCTGTCGTACTGGGCTGTGGCACAGCCTTCGAG
ACAACACGGGTGTATCTCTGATCCTGCCCTACCTAGGCTTCAAGGGGCTTCTGTCTGGAGAAATGCCCTCAAAGGGTAACCAGTAGGTGT
GGCATTGAATTGGCCAGTGTTAGCATCTACAGCCATCACCGAGATGAGTCCACTGCCGTTGCCTGCCCGAGGGCCCCCTAAGGTTATAGA
CGGTATCAGCAGGGAGGCCGTCCCGCTGGTTTTCTAGGAGAGCCCACAGGAGGAAGGGAGCCTCTTCAGGGGCACTGGAATCTTTTGTGC
CAGGGGCTTCTTTTCATCAGAGCCGGGGAGTACATTGCAGTGACTTCTTAAACATTTGTGTGGGACAGACGAGCGTGAGGGAGGTTTTAA
GCCAGGCACAAAGTTAGTTTCCAATACTAGTTAATAAATCTATTTTTCTTCATTTCCTTTTTTTGCACAGAAGCTGGTAATCTAGGACCT
ACGTGTGAACAACTTTATATGAATATTTTTTGTACTTGGTTTACTTGGGTTGGTATGATACATTATATTTAAGTTCCTTGAACACTGTGG
ATCCCCTAATGTGTATGAATGACTGAGGCTTTGTAAATTAAGGGACGTTTGTGTGAATAAAGTTATTTGATGGGGTCAAAGAAGCCATAT

>71363_71363_1_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000264158_STK35_chr20_2083414_ENST00000381482_length(amino acids)=486AA_BP=40
MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGK
DGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARV
AVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFC
EGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVN
KYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSM

--------------------------------------------------------------
>71363_71363_2_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000442034_STK35_chr20_2083414_ENST00000381482_length(transcript)=6280nt_BP=160nt
GCTCCTCAAGATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCCTCGGAATGGGAAAGGTTTAT
TTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATTGGAAACTCTTTGGGAAAGCCACTCGAAAAGGTCACAATCCAAGGTCCGGC
TCCTCCGCGTCCCAGGGCCGGACGGAGGGATGAGGCAGGGGGGGCCCGGGCAGCGCCGTTGCTGCTCCCCCCGCCGCCCGCAGCCATGGA
AACGGGGAAGGACGGCGCCCGCAGAGGTACACAAAGCCCGGAGCGGAAAAGGCGAAGCCCAGTGCCGCGGGCGCCCAGCACGAAGCTGAG
GCCGGCGGCGGCGGCCCGGGCCATGGATCCGGTGGCGGCCGAGGCCCCGGGCGAGGCCTTCCTGGCGCGGCGACGGCCTGAGGGCGGTGG
CGGGTCCGCGCGGCCGCGTTACAGCCTGTTGGCGGAGATCGGGCGCGGCAGCTACGGCGTGGTTTATGAGGCAGTGGCCGGGCGCAGCGG
GGCCCGGGTGGCGGTCAAGAAGATCCGCTGCGACGCCCCCGAGAACGTGGAGCTGGCGCTGGCTGAATTCTGGGCCCTCACCAGCCTCAA
GCGGCGCCACCAGAACGTCGTGCAGTTTGAGGAGTGCGTCCTGCAGCGCAATGGGTTAGCCCAGCGCATGAGTCACGGCAACAAGAGCTC
GCAGCTTTACCTGCGCCTGGTGGAGACCTCGCTGAAAGGAGAAAGGATCCTGGGTTATGCTGAGGAGCCCTGCTATCTCTGGTTTGTCAT
GGAGTTCTGTGAAGGTGGAGACCTGAATCAGTATGTCCTGTCCCGGAGGCCAGACCCAGCCACCAACAAAAGTTTCATGCTACAGCTGAC
GAGCGCCATTGCCTTCCTGCACAAAAACCATATTGTGCACAGGGACCTGAAGCCAGACAACATCCTCATCACAGAGCGGTCTGGCACCCC
CATCCTCAAAGTGGCCGACTTTGGACTAAGCAAGGTCTGTGCTGGGCTGGCACCCCGAGGCAAAGAGGGCAATCAAGACAACAAAAATGT
GAATGTGAATAAGTACTGGCTGTCCTCAGCCTGCGGTTCGGACTTCTACATGGCTCCTGAAGTCTGGGAGGGACACTACACAGCCAAGGC
GGACATCTTTGCCCTGGGCATTATCATCTGGGCAATGATAGAAAGAATCACTTTTATTGACTCTGAGACCAAGAAGGAGCTCCTGGGGAC
CTACATTAAACAGGGGACTGAGATCGTCCCTGTTGGTGAGGCGCTGCTAGAAAACCCAAAGATGGAGTTGCACATCCCCCAAAAACGCAG
GACTTCCATGTCTGAGGGGATCAAGCAGCTCTTGAAAGATATGTTAGCTGCTAACCCACAGGACCGGCCTGATGCCTTTGAACTTGAAAC
CAGAATGGACCAGGTCACATGTGCTGCTTAAAATTCAGGGCTAAGCATTTTGGGTGATTTTAAACTAGGTCGATTCCTCGGGACCCACAG
TCTCACCACGTCTCCTCCAGAGGACGGCAGAGGGTACAGGTGGTGGCCTGGCCGGTTGGCGATCTCCCGACAGCTGGATCCGGCAATGTG
AAGCTTTTGTTTGGGTTTCCCCGCTTCTTTTTAGTTTTGCTTTATTTTTTTCCTTTTCTTTTCTTTTTTTTTTTTCCTCTTTCCTTTTTT
TAAATTTAAACCATTGAGACTTCAGAAGAGCAGGACACAATGCTGTGGACAGGCACCAATTTCTTTAAAGAAATTCAATGTGGGCAAGGC
ATATGTGTAAATTTCACTTTTACTTTTTATAAGGGGTTAGGGAGCTATTTTTGGTTTTGTCCTTCACTTTCCCTCTGTCTTCCTTCTTTA
TACTTTTCTCAGTTCTACTTATGACACCTCACTTCCCTAGAGAAGGCCTGCCTCCCCATAGGGAATCTGGGGGTTTCTTCTGGAACGGGG
CGTGAGGACACAAGGAGGCCTCTGGGCCACGCCTCCCTACCAGATGCAGGAACTCCTGGACTCCTTGGTGGGCTGGCCCTGGCTAGCCCT
TGGGCCTCGGAGATGATCAGAGGTGAAGAACCGCCTGGAAGAGGAAGGCCAGGGTTTGGCCAGGAGAACTAAGAAGGTCTCAACTCCAGG
CTTTGTTGTGTTTAAGCTATTGAGAGCCCCAGGCCACACCAGGACTTGCAGTGGTGGGAATCCATTCCTCTTCTGCCCTGTGTTGCAGGG
AACTAGGAGGTAAGGGTGGAGGGCGACCATCTCGCTCTTGCTGGCGGTGGAGCAGCCATCCCTGCCTTTCTGTTGGGAAAAACTGTTGTG
CCAAACTCTTGTGTGGAACACAGCTGGGTCTTCAGCAGGCATCTGTCACTGCCGTGAGGTCAGCGCTTCTCACCTAACTGCCTCCTGGAT
TGTCATCTTCCCAGATGTGTCCCATAGTGTCCAGGTGTCACAGAGACGGCCTGAGGCCCTAAGATCTGGTTGTGACTTTGCCATGATAAC
AGGGTGTCCTGAACTGGCTGCCGTTGTCGTGTTCTCACAGTGAAGGGCGTGCCCTGTGTGCCGGGGTCCATGGTGTCATATGCAGTGACA
CACACTGTCAAGCGCCATTTCCCTCACCCCTGGAGACTTACTGTTAGGTGCCTGCCCTCAGTATAGACGTATCCAATGGGAAAACAGCGG
ACCTGCCCAGAGCAGGGAGGTGTCGTGGAACTGGGTAGACCCCCTGCAGCGTTAGGGGCCCATTTGTGGGCTCGCCACCTTCAGGCTTCC
CCAGCCATGACACTTCAGCCCCGCCACCCATGCCTGTCTGCTGCAGCCATCCTTGCACTCTCCAGCGACACTCTCGCACCTCCCTAGGGG
AAGCTTCCCTCCCCCTGGGCTGCTGCTCTGAGCCCATCTGTTCTCCCCCTGCAAGAAGGGGCAATGCTCTTGTGTTGTCCCTCTGTCTGG
ACGCGCCTGGCCACTCCGAAGGCTTTTCACCCCATTATGGCCAAATAGTATAGGGCCACTGGGGAGGGGGAAGGGAATCATTTTGTGTTC
ATTTTTGTTTTCTGTTTCACCTAAACCAGCATAGGATTGATAGGGGAGACGGTTGGCGGGCATTTCCGTTTCTATGTGACCAAGGCAGCA
GGGGCTTTTACCTGCTAAGCGGCAATCCTTTGGCCCTGAGAATTTGGGAGAGAACAGTGCATCAGGCCAGGCTCAGCAATATGTTTGCTC
ACATTCTTTCAGCCTTCTGTCACCCCCCTCAACACCAAACTTTCTTCCTTGTGAGCAGAAGGTTGGCTGCTGTTAGCAGGATCCCACAGT
GATAACCAGGCCCTTCCCTTCCTAAGCCAAAACCCATTGTGACTGCCTGTCTCTCCTGTCTCTGACTTCTCAGGCAGCCTCCTGAGTGCA
CTGAGTTGTATCCGAGAGGGTGGGAACAGCAGCATCCCCTAATTGCAGTACACGGTTCCTTTTCCGCCCGCCACCCTGCCTTTCCTTGGG
GGCAGCTGTCTCTCTGTACATGAGCAAATGGGCAAAAACAGTCCCCAAACCCAGCACCCCCCTCTCCCTGGCTGCAGCCCACACTGTAAC
ATCCCTAGTGAGGCTCCAGCCTAATGAGCCCCTTATTTTCTTTTTTTTCCCTCCCCAGGTCTAGTAGCTCTAACTAAAAAGTTCTTGGAG
CCATCGTGCTCCCCCTTTGTTATTTTTCTTGCTATCAGAGTAGCAAGAAACAGCACCCCTGTAGGTGACAGGTGGGCAGCCTGGTAGGGG
TCGCCAGCCTCCATGCCCCCTCATCTTCCAGTTCTTGCTTAGTGGCACGACCTCTTTCCATAGCATAAATGCAGGCCAGCGTTTTAGCCC
CAAGTGCCTGCCCTTGCTTCTTACCCCTCCCCTGCTTTCTCAAACACTTGCCCACCTCAGGCACTCAGCGGGCTCCGCCGTGGTGAGAGA
ACTGGCCGTGGCTCAGCCCCGGGTAGCACCTGTAGTTTCAGTGCCACTCTCCACTGTCCCCTTGTGGACCAGCTTCCACTCACTGTCACG
TCCCCCCTCCTGCGTCTTCACTGGGTCTCAGGCTGCCAGCAGCTCTCTGGTGCATCGTCTCAACACCACCAAGTTTGTAGGACCTGCCCA
AGTTCTAGTAGTATTCAAAACTTCAAACGGCAGTCATTTGTTCTCCTCGGCTCTGTGGCAAGGATAGCCCTTTGGAGGGGGACTCTTGAC
CTCGGCTGTTAGGGATCTGAACTTGGTTTTCCCGTCAGAAGAATCAGCAGGACAGATCGTAGTGCCTTATTCCATTGTCCTCCCCTGGCC
AGGCCTCCTGGCTCAGCTGGAAGTGCATGGCTTCTTTCTCCCTATCTGTGTCCTCTGTCACTTGCTCTTTCACTCTCTCTCTCATTCCCA
GAGAGCCACGGGGGAGGGATCACCCTCACCCCCAACACCCTCTTCCTGAGGGCTGTAGCCAGGTCCGCATCTCCCCACCACCACCAGGGC
ACTCACTCGCAGCTATAGCCCAGGACAGAAAAACTGTGCTTTGGACAGGTGCACACTCTCTGCCTCTTACCTCTAGCCAGGAGGATGCCT
CAGTCTGTTCATTCGAGACTGGCCCCGTCTGAACCTTCTCTGGGCACTGGGGACTAAGGTTGCAGGCCTTAGCCTCGTCTCGTCCCAGAG
GCATTGGATCAGGAGAATGGGAATTTTTTTCCTCCCACCTGGACATAGTTTGCCCCTGTGGCTGCCTTTCTGAGGGAGTATACTAAATGT
TTACTTAAGAAACACCCTGTTTACAGCCAGAGGAGAAACACCCAACACTGAGTGGAGATTTGACTCTGGACAGGGCCTGGCCTCCTTAGT
GGCACTGCCGGGGGGCCCCAGAGCGAATGAGGGCAGAGATGCCCGGGGCAGGGGCAAACGCCCTCCGCTCCCTCTGCTCCCAACCCTGTG
GTGCTAGGACCACTCCCCGCCTTCCCTACGGCCTCCTCGCCCTGCACATTCCCCACCTCCACATTCCCCTCCTCCAAGATCTCAGCTCCT
TAACATATCAGTTGTCTCCTAGCCTAGAAAACCAGTGTTTGGAGCAATAAGATGATTATTTTTGCTTGAATCTTTTTCTAAGAGAAGGAA
AAGAGCTGGCATTGTGGGAATTTTCTTTTTATGCTGTTAGCTGTTTACCTTCTTAGAAGACATCCTAATAGGATGGATGTCTGGGTTTTA
GCCTTGGGGTATCTTTTGGAAACTTAGAAAAGCAGGAGTCAGGCTGCCACCCCCTAAGGAGGGACCCTAACGTTCTGCCCTTGCCTGGTT
CCATATGGCTCCTTCCAGCCCTGCCCACCAAGTGCAGCTCCCACTTTCCATCCTGCCCATACGCCCCTCTTCCCCCGACATCTGGGGGCG
CTGGTGGCACTTACTCTAGGTTGGTCTCAGACTATCCCTCCCCTTGGCTGGTTTTCCCTCCTAGGCCTGTCTGGCAGCCCCCAGACAGAC
GTAGCTCCTGGGAGTCTCGGCCCTGGCAACCTTGGAAGAGCCAAGCTGACATTGTTTAGCTCTTCAGGCCACTGGGTTTTGGAGGCAGAA
GTCCAGAGATACTGGCTCTGCCAAGCTGTCGTACTGGGCTGTGGCACAGCCTTCGAGACAACACGGGTGTATCTCTGATCCTGCCCTACC
TAGGCTTCAAGGGGCTTCTGTCTGGAGAAATGCCCTCAAAGGGTAACCAGTAGGTGTGGCATTGAATTGGCCAGTGTTAGCATCTACAGC
CATCACCGAGATGAGTCCACTGCCGTTGCCTGCCCGAGGGCCCCCTAAGGTTATAGACGGTATCAGCAGGGAGGCCGTCCCGCTGGTTTT
CTAGGAGAGCCCACAGGAGGAAGGGAGCCTCTTCAGGGGCACTGGAATCTTTTGTGCCAGGGGCTTCTTTTCATCAGAGCCGGGGAGTAC
ATTGCAGTGACTTCTTAAACATTTGTGTGGGACAGACGAGCGTGAGGGAGGTTTTAAGCCAGGCACAAAGTTAGTTTCCAATACTAGTTA
ATAAATCTATTTTTCTTCATTTCCTTTTTTTGCACAGAAGCTGGTAATCTAGGACCTACGTGTGAACAACTTTATATGAATATTTTTTGT
ACTTGGTTTACTTGGGTTGGTATGATACATTATATTTAAGTTCCTTGAACACTGTGGATCCCCTAATGTGTATGAATGACTGAGGCTTTG

>71363_71363_2_RAB3GAP1-STK35_RAB3GAP1_chr2_135815656_ENST00000442034_STK35_chr20_2083414_ENST00000381482_length(amino acids)=486AA_BP=40
MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGK
DGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARV
AVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFC
EGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVN
KYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSM

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Fusion Gene PPI Analysis for RAB3GAP1-STK35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB3GAP1-STK35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB3GAP1-STK35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource