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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB7A-TRMT1 (FusionGDB2 ID:71492)

Fusion Gene Summary for RAB7A-TRMT1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB7A-TRMT1
Fusion gene ID: 71492
HgeneTgene
Gene symbol

RAB7A

TRMT1

Gene ID

7879

55687

Gene nameRAB7A, member RAS oncogene familytRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
SynonymsCMT2B|PRO2706|RAB7LCAL3|MTO2|MTU1|TRMT|TRMT1
Cytomap

3q21.3

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-7aRAB7, member RAS oncogene familyRas-associated protein RAB7mitochondrial tRNA-specific 2-thiouridylase 1MTO2 homologlung cancer associated lncRNA 3mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase
Modification date2020032820200313
UniProtAcc.

TRMT1L

Ensembl transtripts involved in fusion geneENST00000265062, ENST00000482525, 
ENST00000485280, 		ENST00000592892, 
ENST00000221504, ENST00000357720, 
ENST00000437766, ENST00000592062, 
Fusion gene scores* DoF score21 X 11 X 12=27724 X 5 X 4=80
# samples 235
** MAII scorelog2(23/2772*10)=-3.59122149119284
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB7A [Title/Abstract] AND TRMT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB7A(128526514)-TRMT1(13221120), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB7A

GO:0022615

protein to membrane docking

24344282


check buttonFusion gene breakpoints across RAB7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PP-01ARAB7Achr3

128526514

+TRMT1chr19

13221120

-
ChimerDB4UCSTCGA-N8-A4PPRAB7Achr3

128526514

+TRMT1chr19

13221120

-


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Fusion Gene ORF analysis for RAB7A-TRMT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265062ENST00000592892RAB7Achr3

128526514

+TRMT1chr19

13221120

-
5CDS-intronENST00000482525ENST00000592892RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000265062ENST00000221504RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000265062ENST00000357720RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000265062ENST00000437766RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000265062ENST00000592062RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000482525ENST00000221504RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000482525ENST00000357720RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000482525ENST00000437766RAB7Achr3

128526514

+TRMT1chr19

13221120

-
In-frameENST00000482525ENST00000592062RAB7Achr3

128526514

+TRMT1chr19

13221120

-
intron-3CDSENST00000485280ENST00000221504RAB7Achr3

128526514

+TRMT1chr19

13221120

-
intron-3CDSENST00000485280ENST00000357720RAB7Achr3

128526514

+TRMT1chr19

13221120

-
intron-3CDSENST00000485280ENST00000437766RAB7Achr3

128526514

+TRMT1chr19

13221120

-
intron-3CDSENST00000485280ENST00000592062RAB7Achr3

128526514

+TRMT1chr19

13221120

-
intron-intronENST00000485280ENST00000592892RAB7Achr3

128526514

+TRMT1chr19

13221120

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265062RAB7Achr3128526514+ENST00000437766TRMT1chr1913221120-19177742461883545
ENST00000265062RAB7Achr3128526514+ENST00000357720TRMT1chr1913221120-19177742461883545
ENST00000265062RAB7Achr3128526514+ENST00000221504TRMT1chr1913221120-18257742461796516
ENST00000265062RAB7Achr3128526514+ENST00000592062TRMT1chr1913221120-19127742461883545
ENST00000482525RAB7Achr3128526514+ENST00000437766TRMT1chr1913221120-17055621751671498
ENST00000482525RAB7Achr3128526514+ENST00000357720TRMT1chr1913221120-17055621751671498
ENST00000482525RAB7Achr3128526514+ENST00000221504TRMT1chr1913221120-16135621751584469
ENST00000482525RAB7Achr3128526514+ENST00000592062TRMT1chr1913221120-17005621751671498

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265062ENST00000437766RAB7Achr3128526514+TRMT1chr1913221120-0.0142029250.9857971
ENST00000265062ENST00000357720RAB7Achr3128526514+TRMT1chr1913221120-0.0142029250.9857971
ENST00000265062ENST00000221504RAB7Achr3128526514+TRMT1chr1913221120-0.0111200670.9888799
ENST00000265062ENST00000592062RAB7Achr3128526514+TRMT1chr1913221120-0.0143941640.9856059
ENST00000482525ENST00000437766RAB7Achr3128526514+TRMT1chr1913221120-0.0308905490.9691095
ENST00000482525ENST00000357720RAB7Achr3128526514+TRMT1chr1913221120-0.0308905490.9691095
ENST00000482525ENST00000221504RAB7Achr3128526514+TRMT1chr1913221120-0.0311603360.96883965
ENST00000482525ENST00000592062RAB7Achr3128526514+TRMT1chr1913221120-0.0313636060.9686364

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Fusion Genomic Features for RAB7A-TRMT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAB7A-TRMT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:128526514/chr19:13221120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TRMT1

TRMT1L

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.733

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB7Achr3:128526514chr19:13221120ENST00000265062+5637_45176208.0MotifEffector region
HgeneRAB7Achr3:128526514chr19:13221120ENST00000265062+56125_128176208.0Nucleotide bindingGTP
HgeneRAB7Achr3:128526514chr19:13221120ENST00000265062+56156_157176208.0Nucleotide bindingGTP
HgeneRAB7Achr3:128526514chr19:13221120ENST00000265062+5615_22176208.0Nucleotide bindingGTP
HgeneRAB7Achr3:128526514chr19:13221120ENST00000265062+5634_40176208.0Nucleotide bindingGTP
HgeneRAB7Achr3:128526514chr19:13221120ENST00000265062+5663_67176208.0Nucleotide bindingGTP
TgeneTRMT1chr3:128526514chr19:13221120ENST00000221504515600_627290631.0Zinc fingerC3H1-type
TgeneTRMT1chr3:128526514chr19:13221120ENST00000357720617600_627290660.0Zinc fingerC3H1-type
TgeneTRMT1chr3:128526514chr19:13221120ENST00000437766516600_627290660.0Zinc fingerC3H1-type
TgeneTRMT1chr3:128526514chr19:13221120ENST00000592062718600_627290660.0Zinc fingerC3H1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRMT1chr3:128526514chr19:13221120ENST0000022150451555_499290631.0DomainTrm1 methyltransferase
TgeneTRMT1chr3:128526514chr19:13221120ENST0000035772061755_499290660.0DomainTrm1 methyltransferase
TgeneTRMT1chr3:128526514chr19:13221120ENST0000043776651655_499290660.0DomainTrm1 methyltransferase
TgeneTRMT1chr3:128526514chr19:13221120ENST0000059206271855_499290660.0DomainTrm1 methyltransferase


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Fusion Gene Sequence for RAB7A-TRMT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71492_71492_1_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000221504_length(transcript)=1825nt_BP=774nt
GTCTCGTGACAGGTACTTCCGCTCGGGGCGGCGGCGGTGGCGGAAGTGGGAGCGGGCCTGGAGTCTTGGCCATAAAGCCTGAGGCGGCGG
CAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTCTGTCCTCCGTTTAGTCTCC
TCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGACCTCTAGGAAGAAAGTGTTG
CTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAAATTCAGCAATCAGTACAAA
GCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATGGGACACAGCAGGACAGGAA
CGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTATTTGATGTGACTGCCCCCAACACATTCAAAACC
CTAGATAGCTGGAGAGATGAGTTTCTCATCCAGGCCAGTCCCCGAGATCCTGAAAACTTCCCATTTGTTGTGTTGGGAAACAAGATTGAC
CTCGAAAACAGACAAGTGGCCACAAAGCGGGCACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAG
GCCATCAACGTGGAGCAGGCGTTCCAGACGATTGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGC
GCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAG
GCCAAGGTCAAGGCCTCAGCCAGGGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACAC
CAGCTTGGTGGCCCCATGTGGGCAGAGCCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGC
TTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTG
AGCAGCACCATCCACTGCAACACACCAAGCCTCCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCC
TGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAG
CGACTATCAGAGACTAGCCCAGCGTTCCGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCC
AGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCG
GCCGACGAAGCTATGGAGGAGAGACGCAGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTC
AAGACATTTCCTTGCAAGAGGTTTAAGGAGGGCACCTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTT
TCTGCTGATGCTGCCCCTGACTGTCCAGAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGAACC

>71492_71492_1_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000221504_length(amino acids)=516AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASARAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLE
AVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWE
KECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPED

--------------------------------------------------------------
>71492_71492_2_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000357720_length(transcript)=1917nt_BP=774nt
GTCTCGTGACAGGTACTTCCGCTCGGGGCGGCGGCGGTGGCGGAAGTGGGAGCGGGCCTGGAGTCTTGGCCATAAAGCCTGAGGCGGCGG
CAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTCTGTCCTCCGTTTAGTCTCC
TCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGACCTCTAGGAAGAAAGTGTTG
CTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAAATTCAGCAATCAGTACAAA
GCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATGGGACACAGCAGGACAGGAA
CGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTATTTGATGTGACTGCCCCCAACACATTCAAAACC
CTAGATAGCTGGAGAGATGAGTTTCTCATCCAGGCCAGTCCCCGAGATCCTGAAAACTTCCCATTTGTTGTGTTGGGAAACAAGATTGAC
CTCGAAAACAGACAAGTGGCCACAAAGCGGGCACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAG
GCCATCAACGTGGAGCAGGCGTTCCAGACGATTGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGC
GCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAG
GCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGCGCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCG
TCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAG
CTTGGTGGCCCCATGTGGGCAGAGCCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTC
CACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGC
AGCACCATCCACTGCAACACACCAAGCCTCCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGT
AAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGA
CTATCAGAGACTAGCCCAGCGTTCCGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGC
TCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCC
GACGAAGCTATGGAGGAGAGACGCAGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAG
ACATTTCCTTGCAAGAGGTTTAAGGAGGGCACCTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCT
GCTGATGCTGCCCCTGACTGTCCAGAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGAACCAAT

>71492_71492_2_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000357720_length(amino acids)=545AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC
EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF
RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR
ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA

--------------------------------------------------------------
>71492_71492_3_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000437766_length(transcript)=1917nt_BP=774nt
GTCTCGTGACAGGTACTTCCGCTCGGGGCGGCGGCGGTGGCGGAAGTGGGAGCGGGCCTGGAGTCTTGGCCATAAAGCCTGAGGCGGCGG
CAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTCTGTCCTCCGTTTAGTCTCC
TCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGACCTCTAGGAAGAAAGTGTTG
CTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAAATTCAGCAATCAGTACAAA
GCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATGGGACACAGCAGGACAGGAA
CGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTATTTGATGTGACTGCCCCCAACACATTCAAAACC
CTAGATAGCTGGAGAGATGAGTTTCTCATCCAGGCCAGTCCCCGAGATCCTGAAAACTTCCCATTTGTTGTGTTGGGAAACAAGATTGAC
CTCGAAAACAGACAAGTGGCCACAAAGCGGGCACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAG
GCCATCAACGTGGAGCAGGCGTTCCAGACGATTGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGC
GCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAG
GCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGCGCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCG
TCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAG
CTTGGTGGCCCCATGTGGGCAGAGCCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTC
CACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGC
AGCACCATCCACTGCAACACACCAAGCCTCCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGT
AAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGA
CTATCAGAGACTAGCCCAGCGTTCCGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGC
TCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCC
GACGAAGCTATGGAGGAGAGACGCAGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAG
ACATTTCCTTGCAAGAGGTTTAAGGAGGGCACCTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCT
GCTGATGCTGCCCCTGACTGTCCAGAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGAACCAAT

>71492_71492_3_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000437766_length(amino acids)=545AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC
EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF
RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR
ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA

--------------------------------------------------------------
>71492_71492_4_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000592062_length(transcript)=1912nt_BP=774nt
GTCTCGTGACAGGTACTTCCGCTCGGGGCGGCGGCGGTGGCGGAAGTGGGAGCGGGCCTGGAGTCTTGGCCATAAAGCCTGAGGCGGCGG
CAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTCTGTCCTCCGTTTAGTCTCC
TCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGACCTCTAGGAAGAAAGTGTTG
CTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAAATTCAGCAATCAGTACAAA
GCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATGGGACACAGCAGGACAGGAA
CGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTATTTGATGTGACTGCCCCCAACACATTCAAAACC
CTAGATAGCTGGAGAGATGAGTTTCTCATCCAGGCCAGTCCCCGAGATCCTGAAAACTTCCCATTTGTTGTGTTGGGAAACAAGATTGAC
CTCGAAAACAGACAAGTGGCCACAAAGCGGGCACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAG
GCCATCAACGTGGAGCAGGCGTTCCAGACGATTGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGC
GCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAG
GCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGCGCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCG
TCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAG
CTTGGTGGCCCCATGTGGGCAGAGCCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTC
CACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGC
AGCACCATCCACTGCAACACACCAAGCCTCCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGT
AAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGA
CTATCAGAGACTAGCCCAGCGTTCCGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGC
TCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCC
GACGAAGCTATGGAGGAGAGACGCAGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAG
ACATTTCCTTGCAAGAGGTTTAAGGAGGGCACCTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCT
GCTGATGCTGCCCCTGACTGTCCAGAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGAACCAAT

>71492_71492_4_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000592062_length(amino acids)=545AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC
EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF
RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR
ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA

--------------------------------------------------------------
>71492_71492_5_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000221504_length(transcript)=1613nt_BP=562nt
ATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTC
TGTCCTCCGTTTAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGAC
CTCTAGGAAGAAAGTGTTGCTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAA
ATTCAGCAATCAGTACAAAGCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATG
GGACACAGCAGGACAGGAACGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTGGCCACAAAGCGGGC
ACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAGGCCATCAACGTGGAGCAGGCGTTCCAGACGAT
TGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCT
GCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAGGGCCAAGTT
CTCTGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAGCTTGGTGGCCCCATGTGGGCAGAGCCCAT
CCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCT
GAGCGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCAAGCCT
CCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGC
CTCTGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTCCGCAT
TCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCA
GGCTAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGCAGGCT
GCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAGACATTTCCTTGCAAGAGGTTTAAGGAGGG
CACCTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCAGAGAC

>71492_71492_5_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000221504_length(amino acids)=469AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASARA
KFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTP
SLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKR
FQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCP

--------------------------------------------------------------
>71492_71492_6_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000357720_length(transcript)=1705nt_BP=562nt
ATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTC
TGTCCTCCGTTTAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGAC
CTCTAGGAAGAAAGTGTTGCTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAA
ATTCAGCAATCAGTACAAAGCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATG
GGACACAGCAGGACAGGAACGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTGGCCACAAAGCGGGC
ACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAGGCCATCAACGTGGAGCAGGCGTTCCAGACGAT
TGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCT
GCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGC
GCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCGTCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTC
TGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAGCTTGGTGGCCCCATGTGGGCAGAGCCCATCCA
TGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAG
CGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCAAGCCTCCT
GCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTC
TGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTCCGCATTCT
CAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGC
TAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGCAGGCTGCT
TCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAGACATTTCCTTGCAAGAGGTTTAAGGAGGGCAC
CTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCAGAGACCTC

>71492_71492_6_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000357720_length(amino acids)=498AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASK
QALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGV
LSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFR
ILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKE

--------------------------------------------------------------
>71492_71492_7_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000437766_length(transcript)=1705nt_BP=562nt
ATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTC
TGTCCTCCGTTTAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGAC
CTCTAGGAAGAAAGTGTTGCTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAA
ATTCAGCAATCAGTACAAAGCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATG
GGACACAGCAGGACAGGAACGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTGGCCACAAAGCGGGC
ACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAGGCCATCAACGTGGAGCAGGCGTTCCAGACGAT
TGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCT
GCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGC
GCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCGTCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTC
TGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAGCTTGGTGGCCCCATGTGGGCAGAGCCCATCCA
TGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAG
CGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCAAGCCTCCT
GCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTC
TGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTCCGCATTCT
CAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGC
TAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGCAGGCTGCT
TCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAGACATTTCCTTGCAAGAGGTTTAAGGAGGGCAC
CTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCAGAGACCTC

>71492_71492_7_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000437766_length(amino acids)=498AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASK
QALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGV
LSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFR
ILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKE

--------------------------------------------------------------
>71492_71492_8_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000592062_length(transcript)=1700nt_BP=562nt
ATAAAGCCTGAGGCGGCGGCAGCGGCGGAGTTGGCGGCTTGGAGAGCTCGGGAGAGTTCCCTGGAACCAGAACTTGGACCTTCTCGCTTC
TGTCCTCCGTTTAGTCTCCTCCTCGGCGGGAGCCCTCGCGACGCGCCCGGCCCGGAGCCCCCAGCGCAGCGGCCGCGTTTGAAGGATGAC
CTCTAGGAAGAAAGTGTTGCTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGGAAGACATCACTCATGAACCAGTATGTGAATAAGAA
ATTCAGCAATCAGTACAAAGCCACAATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAGATATG
GGACACAGCAGGACAGGAACGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGTGCAGACTGCTGCGTTCTGGTGGCCACAAAGCGGGC
ACAGGCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAGGCCATCAACGTGGAGCAGGCGTTCCAGACGAT
TGCACGGAATGCACTTAAGCAGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCT
GCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGC
GCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCGTCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTC
TGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAGCTTGGTGGCCCCATGTGGGCAGAGCCCATCCA
TGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAG
CGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCAAGCCTCCT
GCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTC
TGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTCCGCATTCT
CAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGC
TAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGCAGGCTGCT
TCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAGACATTTCCTTGCAAGAGGTTTAAGGAGGGCAC
CTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCAGAGACCTC

>71492_71492_8_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000592062_length(amino acids)=498AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASK
QALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGV
LSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFR
ILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAB7A-TRMT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB7A-TRMT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB7A-TRMT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource