FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RABGAP1-CDS2 (FusionGDB2 ID:71540)

Fusion Gene Summary for RABGAP1-CDS2

check button Fusion gene summary
Fusion gene informationFusion gene name: RABGAP1-CDS2
Fusion gene ID: 71540
HgeneTgene
Gene symbol

RABGAP1

CDS2

Gene ID

23637

8760

Gene nameRAB GTPase activating protein 1CDP-diacylglycerol synthase 2
SynonymsGAPCENA|TBC1D11-
Cytomap

9q33.2-q33.3

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionrab GTPase-activating protein 1GAP and centrosome-associated proteinRab6 GTPase activating protein, GAPCenATBC1 domain family, member 11rab6 GTPase activating protein (GAP and centrosome-associated)rab6 GTPase-activating protein GAPCenAphosphatidate cytidylyltransferase 2CDP-DAG synthase 2CDP-DG synthase 2CDP-DG synthetase 2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2CDP-diglyceride diphosphorylase 2CDP-diglyceride pyrophosphorylase 2CDP-diglyceride synthase
Modification date2020031320200327
UniProtAcc.

O95674

Ensembl transtripts involved in fusion geneENST00000373643, ENST00000373647, 
ENST00000493854, 		ENST00000379070, 
ENST00000535100, ENST00000379062, 
ENST00000460006, 
Fusion gene scores* DoF score13 X 10 X 7=91010 X 11 X 7=770
# samples 1313
** MAII scorelog2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RABGAP1 [Title/Abstract] AND CDS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRABGAP1(125839041)-CDS2(5170380), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRABGAP1

GO:0043087

regulation of GTPase activity

17562788


check buttonFusion gene breakpoints across RABGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NRABGAP1chr9

125839041

+CDS2chr20

5170380

+


Top

Fusion Gene ORF analysis for RABGAP1-CDS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000373643ENST00000379070RABGAP1chr9

125839041

+CDS2chr20

5170380

+
5CDS-3UTRENST00000373643ENST00000535100RABGAP1chr9

125839041

+CDS2chr20

5170380

+
5CDS-3UTRENST00000373647ENST00000379070RABGAP1chr9

125839041

+CDS2chr20

5170380

+
5CDS-3UTRENST00000373647ENST00000535100RABGAP1chr9

125839041

+CDS2chr20

5170380

+
In-frameENST00000373643ENST00000379062RABGAP1chr9

125839041

+CDS2chr20

5170380

+
In-frameENST00000373643ENST00000460006RABGAP1chr9

125839041

+CDS2chr20

5170380

+
In-frameENST00000373647ENST00000379062RABGAP1chr9

125839041

+CDS2chr20

5170380

+
In-frameENST00000373647ENST00000460006RABGAP1chr9

125839041

+CDS2chr20

5170380

+
intron-3CDSENST00000493854ENST00000379062RABGAP1chr9

125839041

+CDS2chr20

5170380

+
intron-3CDSENST00000493854ENST00000460006RABGAP1chr9

125839041

+CDS2chr20

5170380

+
intron-3UTRENST00000493854ENST00000379070RABGAP1chr9

125839041

+CDS2chr20

5170380

+
intron-3UTRENST00000493854ENST00000535100RABGAP1chr9

125839041

+CDS2chr20

5170380

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373647RABGAP1chr9125839041+ENST00000460006CDS2chr205170380+1044825581342794886
ENST00000373647RABGAP1chr9125839041+ENST00000379062CDS2chr205170380+292525581342794886
ENST00000373643RABGAP1chr9125839041+ENST00000460006CDS2chr205170380+87548641951100301
ENST00000373643RABGAP1chr9125839041+ENST00000379062CDS2chr205170380+12318641951100301

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373647ENST00000460006RABGAP1chr9125839041+CDS2chr205170380+0.0001093580.9998907
ENST00000373647ENST00000379062RABGAP1chr9125839041+CDS2chr205170380+0.0002270610.99977297
ENST00000373643ENST00000460006RABGAP1chr9125839041+CDS2chr205170380+0.0018018870.9981981
ENST00000373643ENST00000379062RABGAP1chr9125839041+CDS2chr205170380+0.0010510140.998949

Top

Fusion Genomic Features for RABGAP1-CDS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RABGAP1chr9125839041+CDS2chr205170380+1.10E-050.99998903
RABGAP1chr9125839041+CDS2chr205170380+1.10E-050.99998903

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RABGAP1-CDS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:125839041/chr20:5170380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDS2

O95674

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRABGAP1chr9:125839041chr20:5170380ENST00000373647+1926142_2988081070.0DomainPID
HgeneRABGAP1chr9:125839041chr20:5170380ENST00000373647+1926566_7528081070.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRABGAP1chr9:125839041chr20:5170380ENST00000373647+1926798_10478081070.0Coiled coilOntology_term=ECO:0000255
TgeneCDS2chr9:125839041chr20:5170380ENST000004600061013132_152367446.0TransmembraneHelical
TgeneCDS2chr9:125839041chr20:5170380ENST000004600061013166_186367446.0TransmembraneHelical
TgeneCDS2chr9:125839041chr20:5170380ENST000004600061013213_233367446.0TransmembraneHelical
TgeneCDS2chr9:125839041chr20:5170380ENST000004600061013262_282367446.0TransmembraneHelical
TgeneCDS2chr9:125839041chr20:5170380ENST000004600061013340_360367446.0TransmembraneHelical
TgeneCDS2chr9:125839041chr20:5170380ENST00000460006101379_99367446.0TransmembraneHelical


Top

Fusion Gene Sequence for RABGAP1-CDS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71540_71540_1_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373643_CDS2_chr20_5170380_ENST00000379062_length(transcript)=1231nt_BP=864nt
AATTAGTTGCTAAAGATGCCAGAGTGTGTGCACGTACAGGCTTTTTCTTTCCCCTCCCCCTTTCTTCCTTTTCCCAAGCCCCCTCTTCTC
CCTGTTTCCCCTCCTACTCCTTTATCTCCTCCCTCCGTGTCTTAGTTCTGCAGTACGCGGGTTGAAGCACATTCCTGCTTTGCAAGGCTT
TCTGCTAAGGATGTATTGTGGCTTTTGTTTGGATTGCAGCATGCAGAATTACAGGAGTCTCCCCAGGACAGTGCTATCACCCGGGATATT
AACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAATATGCAAGGCTTATTCTGTG
TATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGAAGAACAGGCATTCAGTGTT
CTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAAATTTTACCAGTTGGAGCGC
CTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGCCTCCCAGTGGTTTCTTACT
CTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAGTGTTATTTTTAATGTCGCC
CTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAGGGTTCAGCTTCCTAAGAGA
TACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGGACTTTGCCAATACCATTCCTGGCCATGGAGGCATC
ATGGATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTTATCAGAGGCCCTAACCCAAGCAAACTG
ATTCAGCAGTTCCTGACTTTACGGCCAGATCAGCAGCTCCACATCTTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACA
TCCACCACAGAGGACGAGTAGGGGCCACCCAGGGCCAGGAGAACAGGAACAGAACTGAGCAGGGGCAGGTCTCCAAGGCAAGCCCAGCTG

>71540_71540_1_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373643_CDS2_chr20_5170380_ENST00000379062_length(amino acids)=301AA_BP=223
MWLLFGLQHAELQESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIM
FDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK
TSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFL

--------------------------------------------------------------
>71540_71540_2_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373643_CDS2_chr20_5170380_ENST00000460006_length(transcript)=8754nt_BP=864nt
AATTAGTTGCTAAAGATGCCAGAGTGTGTGCACGTACAGGCTTTTTCTTTCCCCTCCCCCTTTCTTCCTTTTCCCAAGCCCCCTCTTCTC
CCTGTTTCCCCTCCTACTCCTTTATCTCCTCCCTCCGTGTCTTAGTTCTGCAGTACGCGGGTTGAAGCACATTCCTGCTTTGCAAGGCTT
TCTGCTAAGGATGTATTGTGGCTTTTGTTTGGATTGCAGCATGCAGAATTACAGGAGTCTCCCCAGGACAGTGCTATCACCCGGGATATT
AACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAATATGCAAGGCTTATTCTGTG
TATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGAAGAACAGGCATTCAGTGTT
CTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAAATTTTACCAGTTGGAGCGC
CTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGCCTCCCAGTGGTTTCTTACT
CTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAGTGTTATTTTTAATGTCGCC
CTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAGGGTTCAGCTTCCTAAGAGA
TACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGGACTTTGCCAATACCATTCCTGGCCATGGAGGCATC
ATGGATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTTATCAGAGGCCCTAACCCAAGCAAACTG
ATTCAGCAGTTCCTGACTTTACGGCCAGATCAGCAGCTCCACATCTTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACA
TCCACCACAGAGGACGAGTAGGGGCCACCCAGGGCCAGGAGAACAGGAACAGAACTGAGCAGGGGCAGGTCTCCAAGGCAAGCCCAGCTG
GTGTGACTTAGACAATGACGAGGCTTCAACTCACTGTCTTTTTTTTTTTTTTTTGGAGGGTATTTTTTATTTGTGGGTTCAAAAAATCTG
TATATACAGTCTATGTGTTTAGAATTTGTGTTGTAAGTAAACTACAGCTTTGAGTTGGAAAGAAGTCACGGGTTGTAAAACCATTTGGAT
TTTTTTAAAACAAAAGTATTAATAATCTGGAAGACAGTGTTGCCCAGGTCAGGAGTGTTTTCTTGGTGGTTCCAGCCCCCATCAATTGAA
CTGTTTCTGGGCTCAGTCAGACACAGACATTCATCTGTGTCTGACCAAATCAGGGGACTTCCCCACCTGTGGTGGGAGGCACAGCTTAGA
TGTTTTGTACACCTGGTCTTTTCTAGAAATCCCTGCTTGGAGCTGCAGAAGGGTTGCCTTCTGTAGGTCGGAGGAATGGAGGCTTACTAA
CCAGGTAAGCCTTCTATGCATCCACACCAAAATCCTGCAGAATGTAAGTAAGCTCTGCTTTATAAGATGGGTTCACCTTCATCGCAGACT
GAAAGTTTCAGTTTTTATTTTTTTCAGAAAGCACGAAAAATTATTTATAATAGTCTGGAGAAAAAACACACTGTAATATTTCAAGTGTAT
GCAGTAGAATGTACTGTAACTGAGCCCTTTCCCACATGTCTAGGCTCCAATGTCTCCTGTAGGTCCACCTAACTGTGTGTTTTCAGGGAC
AATGCCATCCATGTTTGTGCTGTAGACTTGCTGCTGCTGAATCCTTTCTGGGGACTTTCTCATCGGGCAGGGAGCAGAGGGCTTCTCGTT
CATGCACCCTTTGCCTGAACACCCATGTAGCTGCTGTGTTGTGTATATATTACTCTTAAGAGGAGTGTGTGTGTCTGTGTTTGTTTTAAA
AGTCACTTATTTCTTACAGTGATTTCAATTGCACCATGACTTCTTCACTAAAACCACAAAGTCCTGCTTAAAACTATGGAAAACCTAACC
TGATTAGAGCCTTGACTATTTTGAAGATTAAATGCACACTTTTTATATAATGTGACCAGTTTAAATGTAGTTTGTATTGTACTGGGGGAC
CTTTCGTTGTTGTTGTTTGCTTAAACTGTGATTTTTTTTCCCCTCCCTAATTTCAGGGGTGAGATTGACTTTGGGAAGACAGATTAGTTC
TTTGTCAGGCCAACAAGTGATGGAGTGCGGGAGAGAGAACTTGGCACCCAAATATATCAAACTATTCCGTGCCGTGGATGTTTTCATTGC
CAACGAGGGTGTAATGATTTGCTTCTGCACCTTGGTCTAGTGCTGGTTTGTGGTGTTTTTGTTTGTAAATTAGCCTCACTGCCTCCCTGA
AAGTGCACAGTCAGCCCAGGTCTCTAGAGTGTCCAGCAGAGGATGGAGCCCTCGGGATGTTTCAGCTCACACATCCTTGAGTGACTTCCC
ATATGTGTGTGGGGCTGAAGCGGCTTCTTTCCGCTGAACTTTTATTTCCATTTCAGCCTCGTGGCTTCTCTTATTCAGGTCCAAGGCCCC
TTAAAAACAAAACATATTATCGCAAGGGCTTTCATTTCAGTATTGGCTGTGTCACTGGCAGGATGCATCACTCTCCAGGGCCTCTTTTTC
GGAGCTACTCCCAATTCCACTCTTCTGTGATTCTGGCTGAGCAAGTTCATGCCGGTAGAGGCTCATTAAGTGAGGTCCTGGGCACCCCCC
AAACAGGAAGTGTTTTCAGGCCCTTACATGCTTATCCTTAAGGTGAGTAGGTATCTCAGCAGCACACCCGAACAGTAAAGGTGATCAATA
ACGAAACTGTAGTTTTCAGATTGAAGAATGAACCTGGATCACCAAACTAGATACCGAAAGGGCTCCTCATTTGTCTCTTTTGTCCCATTG
TGGGCATATGGTGGGCTCCTTGAGAGGAGGGAGTCTCAGCTGGGGCCTGGCTGCAGAGACCTGCTCTTGAATAGGGCTGCCTTTGGGATC
AGGGAGCCGAGCATACTGGGCAAGGCTCATCATGTTCCTTTGTGGAAGTGGTTACTTGGTGGGGGTGGGGTGGGGAAGGGGGGTCTAGGA
AGCCGAAGCTGAGTGCGCACTAGAGCTGCTAGCAGGCAGGCCAGAGGGTCAGCTTGTGTTTTATTTTCTGATTTCTCCTGCATGCTTTCT
GGAGATGAGGATTTTTTGTCAGGTAGCTAGGAGAGCACTGCCACCTTGTGTCCATATAGCACAATGTTTCTCTTTCCTATTCACAGACAA
GATTCAAGAAACCATTTTTACGTGTGTACATTCAAATCTTCATGAATGGCATCACTTGCTTTAGACCCATTTTTTTTTTATTGGTCAGAA
ATAAAATGTGACTGCAACTGTGTGCCCTCCCTTGTCGTGAATTCCCTGTTTATCACTTCCATGCATGGTTTTATGCTTCTCATTTGTTTA
TGTATTCATGAATACTGCATAGTCCTGATTCAGAGACTTTTGCTTTGCTTTCCAACTTGTATCCCTACATTCTCACAACAGCCTTCTTAC
CTCGGGTGAGAGTCATGAGCACCTTACCAGGCAGGGAGCTTCCCCAGGATAGTGTGGTGGAGTCAGGACTCACTCCATCCTGCACTTTAC
CCACAGGACACCTGGAGGGTCCCCCAGCCCTGCTTGCTTTTGTGAACGTCGTGTGAGTACACCGAGGTGTTGCAGCTTTCCTTCCCTCTA
GCTCAGGAGGCCTGGCCTGAGCCAGGTTGGAGCTTAAATTGCTGTTGGCTCCTGCCTGGTGGAACAAGGGGGTCATAGAAACCAGGGCTG
ATGGGCACCCCCCAGCCCCTGGGAGCTCTGCTCATGACCGCTCACAGGGTACCGAGTCTTTGCCTTTTGTGTGTGCGCATGCTGCCCTCT
TAACTGCTTTTAGTATTCAGAAAGGTTCCATTTATGTTTTACTCCTGAAAGTGAAACCCTCTTAGGCAACTTGTTTCATATTCTGGGCAT
TTTAGTAGCTACAGTATTTTGCATTTAAAATGTAATTACTCTTAGTATTGTACAGCCCTATAATGTATGAGAACTAGTTTCACATCCTTT
GAAACTAATCTCTTTCATTGGGGAGGATACAACTTTTGACTTTACACAGGTGGACTTTGAATCCATTTTTATAGAATTTTTTTCCACTGT
AACTTGACCTATATTATGCAAGAAAATCCCAAAAATATGTTTTAAGGGAGACTACACAGACCTTGTGATTTGGTCTGAGCTAGTTGCTGA
GTTGACTGGAGCCTTATTTGAATGGATCTTTGAGTTGAGATCTTCACACTGTCAGTGAGCCCTTGGCTCAGCCCTTGTCACCTGTTTGTA
TGGGGACCATGTTTCCCAAAGCTCAGGTTCATCTCCACTATTGACAGAGTCGGGTAGTGGGAGAGTATAAGTGACTTGAGACAGAGTGTC
CTTGCTCAGAAAACTGTGAAGCAGGGGTCTTGTTAGTTACAAAGCCAGTCCTAGTTGCATGTCCAAGGGGGTAGATTTTCATCACCCTAC
TAAATGTGGTATGTCACTGCTGAAGCCTTTTCCTGTTTTAGTAATATCTTAGGCACTATTGTCTTTTGTCTTCCAGAGTAACATATCTGG
GCCCACCTTTCTTGCACACTGTGATTATGTGCTAAGAAAAGGGTGGAGTTGGGAGGACAATTTCACTTGAACAGGTTTCTGTTCTTCTGA
GGTCAGGGTGGGGAGGATGTCCAGGTGACTTTTATGGACACATTGCAAGACAGTAAGCCGCGGATGGACTCTCACTTGTGCTTTGGAACA
CTGGACTCCAAAGAGCAGGTGGAACAAACTCTGGCCTGAAGATGATGGCTAATACTCAGGCAGAGCCCCGTATTCTTCCCTGACTTGGTC
AAAACAAACTTCCTTTTCCCTTGATCACCCTGCACGCAGCTGCCCAGCTTCCAGTTTTTAAAGAGATGAACAGCTCTCACTTCCTGACTC
AGTTTCTCTTGTTGGGTGGGGGCCTTGTGCCACAACCTGCATGGGGTGCTAGGGTTTAAACCAAGTGGTCACGAAGGATTCTTATCTCAG
GGCTCTGCCTGGCCCACCTTCTCTTGGGCCTGGACTCTCCTTATCCACATCCCTGCAGAAGGTGGGCCCTATTCTCAGAAGAGTCCTGGC
TGCTGTTGCCATCTGAATGCGCCCTTCCCTTTCAGGTTGACCAGCAGTGGCCTTACCTGGCCTCTCAGGTGGATGGAGGCTGTTCTCATC
TGGGGCTGTCTCTTGATTAAGGCTGTCACCTGTTTGTATAGGGACCATGTTTCCCAACGCACTTTGAGTGCAGTTTAGGAGGTATCCTTT
GGATGCTGAAGTGTTGGGATTTTGAGGACATGCGGATGATTTATGAGAATAGAGGGGCAGAGTTTGTGAAGTCTAGGGTTTTTTGTCCAG
TGGGTTTCAAATTTGTTGGCTGTTTAAAGACCCTGTCTCCTCCCCCACCCTCCCCTTCCTTTTCCCATCAAATGCCTACCTACTGAGGCG
CCTTCTCTTTTTATTCTTGAGCCAATGAGATATCAGTGTGTTTATTAATAAGGATTGCAATAGTATAGTGCTTAATATGTGCCAGGCATA
GTGCTAAGGGTTTACATACGTTATCCCTTTTAATCCAGAAAACAGCCTTTGATTAGGTATTGTTGTCTCCATTTTATAGATGAGGAAACT
GAGGCAGTATGACTGAGGCCGAGAGCAGTGGTTAAGACAGACTTTGGGATCAAATCACCCTAGGTGCGGGCAGGTTTCTAGGCTGCTCTA
AGCTTCTACCTTGAAGGCAGTTGGGTCTGATAATAGTACCTTCTTCCTGGGGTGGTTGTGAGGATATAACGAGGTAATGCATGTAAGCAT
TTAGTACCATGCCTGGCACATAGTAAGCACTCAATAAATGGTAGTTACTTTTGTTGAGCTCAGCTGGTAGTTTGACCTCCGTTGGTGCAA
TGCCAGAGATGGGATTGTCAGCCACCACACTGCCACCACCCTGCACACAGTCTGGGTCCCTCCGAGAGAAGCACGCCAACCTTAACATCC
CCTACAGCATCTTGGTGCTTCACACACCATTTAGGAGGCCACCCTAACGAGGCAAGAGGACATGGGGGTGTGCAGAAGTTCTGTTCTTAG
TGAGAATGGCTGGCCTGAGAATCCAGCTCACCTCCTCTGCCCACAGTCTGGACTGCTTGTGGGAAGGCCATCTCCTCCTGTCTGGTGGTA
CCTCCACTCTGGGCAGGGAGGGCCTGTCTGTGACTCGCTCTGGACCCCACTTCCCGCTCTGGCCAAGGGCTGTCTTCTGTGCACATAGCT
CAGGAGCCTGCAGCAGTTCCCTGTATGGGTGGATGTCCTCAGGGGCCAAGAAGAGAAGAATGGGGACAACAGAAACCTGCTTTGTAGGGG
ATTATGTAGACTAAAAGCCTAGAAGTTCTGCCCACATCCTTATGACGCAGCCAATCTGGAGCTTCATGTTTCCTTCTAAAAGTAGTAACC
GGGTAGAAGTGGGTGACCCATTGAGGACACATGATGTGAGGTATTTCTGCCGGATTCTAGGTTAGCAAAGACTCAAATGGGTGACTCATG
AATGAAGGGAGAACAGGCACAGGACTTAATGAAAAGAGTTTCTTGAACTTAGTTTTCTGAATGGGGGTGGGGAGTTGGGGCACGTGTGTG
TAAGGGGAGGCTGCCTCACTTTGAAGGAATGGTGTTGGCTAACAGGATCCATGAAATTCCTAGGTCAGTTGAATAATAACTGAACTACTG
GTTTGACTGTGGATTATTTCCTGGGTATTAGTGGGACCCAACAGCACATTGCTATTAATAGTATGGAAATAATGGTCCCTCTGTTTCATT
GAATTGCTGAAGTAATGATAATGCCATGAACCAGGAGAAGATGGTTGTGGGGGTTTCTAGGAAGCAGCTGCTGTGACAGGCCAATCCCAG
GCTTGCCCCCGAGCCCTCCTGTCCTTCTGGGTTTGTGTTTGCCTTGCCTGGTGCTTCCTCCCTCATTGTGTTGTTGAATAGACCTAGGCA
GCCTTGTATCCATAGAAAGCCTCCACTGCTGGGCCGGGGAGGGGGTTGTGGTAAGGGCCCTCTGGAAATCAAGCAGAGAATGCCTTTGCA
GTGGTCTCCCGGGCATTGGGCAGGGCCTAGCCTTTTGCAGCCCCCAGAGGACCTTGCCTGCATAAAGCACTCAGAAGGGTTAGCCACCTG
GTGATTTTGTCTCTAGTGAAACTGTGTTTGCCGATAATCATCCACATAGCCACCTCTGTCCTCGCAGTTTGGATGCCTTTTTTTGACACC
TGCGCTAGGTTCTTGTATGCTGGCTTTTCTTAAAGGAACAGCAGAGTAGAAAAGAGGTTGAGAATGTTTTCTAGCAGGCAGAATGTGCAT
ACATGTTTTCATGAGTGTCCTTTGGGTGCTGTTTCTTTTAAATCCTCTGTGCACAGGGCTCTGGCCTTTAGTAAACTGTTTTTCTGTCTT
ACGTCATGCTGACTGGGTGCTAGGGGCTGATTACAAAGGGGAAGAGTTGAACAGACATCAGGGGCCGATGAAACCAAAGGACTAGGAGTC
AGGAGAACAAGTCAGGGATTAGGAGACAGCGGTTTGGTTTATTGTTATCCAGCTGGAGGACTCCTAGGGGCAGCAGCAGGAGGAATACCA
GGGCCACGGAGGGGCCAGGAGTCTCACAGTGGAGGGCAGACTCTAACAGATGCCAGCTGAACGCTCGCTGGCCCTGGATGTCATACGAGT
TGGGGACCAGAAATCTGGGCTCAGAGAACCCGTCCAGGGAGATTTGAAGCCATGGGTTATCTTCTAGAGTTGATACTGATAATATATTTT
AATTTTTATTGATGTTTAATACCTTCTGAAACAGGAGGGTAAGATCAGATGGGAAGCCCCTCTGTTGAAGGATCTTGGGAACCTTGGTGG
TTTTTTTTTTTTTTTTGGTTTTTTTTTTTTGATCGAGCTGTGGACATCCTTCTTAATTCGATTCTGAGGATTTGTTTAACTAAAAAGTTC
CCAAACACAGAAAGGGCCTCCCCACCTGCTTTGGGGAGCTGTCTGTGCTGGGAGTGCCAGGCATCCCATGGGACCCATCACTGCCAGTGT
CTGTGCCTCCCAGAGGTCAGCCGTGTCTGCCCTGGCTCTGTCTCCTCTGTGACAGGGCAGAGCATTTCTGGTCAGTTTCTCCATGGTGCC
TCCCACCCCTTTGTAAAGTGGATGGACATGATGGAATTCAGTTGTCTCACCCTGATAGCCTGGGTGTTGATATTCACTTTACCCGCACTC
AGACACAGGCGACCTTGAAGCAGTTCTCGGTGTGTAGAGTCCACGTGACAGTCCCCACAGCCTCCCCAGATAGCTGTGTGCCTGTGCGCT
ACTGCTGTGCCATTTTCCCAACTTGGCGTTTCACTAAATGCAGCTGATCTCTCTCTCTGTGCACTCGTGATCCATGTTGAACAATACATG
TAGGTTCTTTTTCCACGCAATGTAAGAACATGATATACTGTACGTTGGAAAGCATTTACCTTATTTATATACCTGAATGTTCCTACTACA

>71540_71540_2_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373643_CDS2_chr20_5170380_ENST00000460006_length(amino acids)=301AA_BP=223
MWLLFGLQHAELQESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIM
FDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK
TSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFL

--------------------------------------------------------------
>71540_71540_3_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373647_CDS2_chr20_5170380_ENST00000379062_length(transcript)=2925nt_BP=2558nt
GGGGACAGGGCGGTTTGGGAGGCCCAGGCGGCGGAGCCTCCGGGACGGCGAGCGGCGGGCGGCGGAGGAGGAGACGGCAGGTCGGGCATT
AAAAAATATTTAATCATTCATGTGTTGAGACTCATTCTTGAGTTATGGATGACAAGGCTTCTGTTGGAAAAATCAGTGTCTCTTCAGACT
CAGTATCTACTCTTAATAGTGAAGATTTTGTCTTGGTTTCCAGGCAAGGAGATGAGACACCATCTACAAATAATGGAAGTGATGATGAGA
AAACAGGACTCAAGATTGTAGGGAATGGAAGTGAACAGCAGCTGCAAAAAGAGCTAGCAGATGTACTGATGGATCCTCCAATGGACGACC
AGCCAGGGGAAAAGGAGCTTGTGAAAAGGTCACAACTGGATGGTGAAGGAGATGGGCCTCTTTCTAATCAGCTCTCCGCTTCATCCACCA
TTAACCCTGTGCCATTAGTAGGGCTCCAAAAACCAGAGATGAGCCTACCAGTGAAACCTGGACAAGGAGATTCTGAAGCTTCAAGTCCTT
TCACACCAGTGGCCGATGAGGACAGCGTAGTTTTCAGTAAACTGACTTACTTAGGCTGTGCCTCGGTAAATGCTCCCAGGAGTGAAGTGG
AAGCCTTAAGGATGATGTCCATCTTAAGAAGCCAGTGTCAGATTTCACTAGATGTTACCCTTTCAGTGCCGAATGTGTCTGAAGGAATTG
TGAGACTCTTAGATCCTCAGACAAACACTGAAATAGCAAACTACCCTATCTACAAAATCCTCTTCTGTGTCAGAGGGCATGATGGAACTC
CTGAGAGTGACTGTTTTGCTTTCACTGAAAGTCATTACAATGCAGAGCTCTTCAGAATACACGTCTTCCGGTGTGAAATACAAGAAGCTG
TAAGCCGGATACTTTACAGTTTTGCCACTGCCTTCCGCCGTTCTGCCAAGCAGACCCCACTTTCAGCCACTGCTGCACCCCAGACTCCTG
ACAGTGACATCTTTACCTTCTCTGTGTCTTTAGAAATAAAAGAAGATGATGGTAAAGGTTATTTTAGTGCAGTTCCCAAAGATAAGGACA
GACAGTGCTTTAAACTACGCCAAGGAATTGATAAGAAGATTGTCATCTATGTGCAGCAAACAACTAATAAAGAACTTGCCATTGAAAGGT
GTTTTGGTCTTCTCCTTAGTCCAGGAAAAGATGTACGAAATAGTGACATGCACTTATTAGATTTGGAATCTATGGGCAAAAGTTCAGATG
GAAAGTCGTATGTTATTACGGGGAGCTGGAATCCAAAATCCCCACATTTTCAAGTTGTAAATGAAGAAACTCCTAAAGATAAAGTCCTGT
TTATGACCACAGCTGTAGATTTGGTAATAACAGAAGTACAGGAGCCTGTTCGATTTCTCCTGGAGACAAAAGTCCGCGTTTGCTCACCTA
ATGAAAGATTATTCTGGCCCTTCAGCAAACGTAGTACTACTGAAAATTTCTTTTTGAAACTAAAACAGATAAAGCAAAGGGAGAGAAAGA
ATAATACTGACACTTTATATGAAGTTGTATGCTTGGAAAGTGAATCAGAAAGAGAGAGGAGGAAAACTACAGCCAGTCCTTCAGTTCGCC
TGCCACAGTCTGGATCGCAAAGTTCAGTGATACCTTCTCCTCCAGAAGATGATGAAGAGGAAGATAATGATGAACCTCTCCTGAGTGGAT
CTGGTGATGTATCCAAAGAATGTGCAGAAAAAATTCTTGAAACATGGGGAGAACTGTTGTCAAAATGGCATCTCAACTTGAATGTGAGAC
CGAAGCAGTTGTCATCCTTAGTAAGAAACGGTGTCCCTGAAGCTCTTCGAGGAGAAGTCTGGCAGCTGCTAGCAGGCTGTCATAACAATG
ACCACCTGGTAGAGAAATACCGCATTCTTATCACAAAGGAGTCTCCCCAGGACAGTGCTATCACCCGGGATATTAACCGAACATTCCCAG
CCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAATATGCAAGGCTTATTCTGTGTATGATGAAGAGATTG
GTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGAAGAACAGGCATTCAGTGTTCTGGTCAAGATCATGT
TTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAAATTTTACCAGTTGGAGCGCCTCATGCAGGAATACA
TTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGCCTCCCAGTGGTTTCTTACTCTTTTCACTGCAAAAT
TCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAGTGTTATTTTTAATGTCGCCCTTGGATTATTAAAGA
CTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAGGGTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAA
ATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGGACTTTGCCAATACCATTCCTGGCCATGGAGGCATCATGGATCGCTTTGACT
GCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTTATCAGAGGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGA
CTTTACGGCCAGATCAGCAGCTCCACATCTTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACATCCACCACAGAGGACG
AGTAGGGGCCACCCAGGGCCAGGAGAACAGGAACAGAACTGAGCAGGGGCAGGTCTCCAAGGCAAGCCCAGCTGGTGTGACTTAGACAAT

>71540_71540_3_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373647_CDS2_chr20_5170380_ENST00000379062_length(amino acids)=886AA_BP=808
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDG
EGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRS
AKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTE
NFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDS
LYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEA
HMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKDF

--------------------------------------------------------------
>71540_71540_4_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373647_CDS2_chr20_5170380_ENST00000460006_length(transcript)=10448nt_BP=2558nt
GGGGACAGGGCGGTTTGGGAGGCCCAGGCGGCGGAGCCTCCGGGACGGCGAGCGGCGGGCGGCGGAGGAGGAGACGGCAGGTCGGGCATT
AAAAAATATTTAATCATTCATGTGTTGAGACTCATTCTTGAGTTATGGATGACAAGGCTTCTGTTGGAAAAATCAGTGTCTCTTCAGACT
CAGTATCTACTCTTAATAGTGAAGATTTTGTCTTGGTTTCCAGGCAAGGAGATGAGACACCATCTACAAATAATGGAAGTGATGATGAGA
AAACAGGACTCAAGATTGTAGGGAATGGAAGTGAACAGCAGCTGCAAAAAGAGCTAGCAGATGTACTGATGGATCCTCCAATGGACGACC
AGCCAGGGGAAAAGGAGCTTGTGAAAAGGTCACAACTGGATGGTGAAGGAGATGGGCCTCTTTCTAATCAGCTCTCCGCTTCATCCACCA
TTAACCCTGTGCCATTAGTAGGGCTCCAAAAACCAGAGATGAGCCTACCAGTGAAACCTGGACAAGGAGATTCTGAAGCTTCAAGTCCTT
TCACACCAGTGGCCGATGAGGACAGCGTAGTTTTCAGTAAACTGACTTACTTAGGCTGTGCCTCGGTAAATGCTCCCAGGAGTGAAGTGG
AAGCCTTAAGGATGATGTCCATCTTAAGAAGCCAGTGTCAGATTTCACTAGATGTTACCCTTTCAGTGCCGAATGTGTCTGAAGGAATTG
TGAGACTCTTAGATCCTCAGACAAACACTGAAATAGCAAACTACCCTATCTACAAAATCCTCTTCTGTGTCAGAGGGCATGATGGAACTC
CTGAGAGTGACTGTTTTGCTTTCACTGAAAGTCATTACAATGCAGAGCTCTTCAGAATACACGTCTTCCGGTGTGAAATACAAGAAGCTG
TAAGCCGGATACTTTACAGTTTTGCCACTGCCTTCCGCCGTTCTGCCAAGCAGACCCCACTTTCAGCCACTGCTGCACCCCAGACTCCTG
ACAGTGACATCTTTACCTTCTCTGTGTCTTTAGAAATAAAAGAAGATGATGGTAAAGGTTATTTTAGTGCAGTTCCCAAAGATAAGGACA
GACAGTGCTTTAAACTACGCCAAGGAATTGATAAGAAGATTGTCATCTATGTGCAGCAAACAACTAATAAAGAACTTGCCATTGAAAGGT
GTTTTGGTCTTCTCCTTAGTCCAGGAAAAGATGTACGAAATAGTGACATGCACTTATTAGATTTGGAATCTATGGGCAAAAGTTCAGATG
GAAAGTCGTATGTTATTACGGGGAGCTGGAATCCAAAATCCCCACATTTTCAAGTTGTAAATGAAGAAACTCCTAAAGATAAAGTCCTGT
TTATGACCACAGCTGTAGATTTGGTAATAACAGAAGTACAGGAGCCTGTTCGATTTCTCCTGGAGACAAAAGTCCGCGTTTGCTCACCTA
ATGAAAGATTATTCTGGCCCTTCAGCAAACGTAGTACTACTGAAAATTTCTTTTTGAAACTAAAACAGATAAAGCAAAGGGAGAGAAAGA
ATAATACTGACACTTTATATGAAGTTGTATGCTTGGAAAGTGAATCAGAAAGAGAGAGGAGGAAAACTACAGCCAGTCCTTCAGTTCGCC
TGCCACAGTCTGGATCGCAAAGTTCAGTGATACCTTCTCCTCCAGAAGATGATGAAGAGGAAGATAATGATGAACCTCTCCTGAGTGGAT
CTGGTGATGTATCCAAAGAATGTGCAGAAAAAATTCTTGAAACATGGGGAGAACTGTTGTCAAAATGGCATCTCAACTTGAATGTGAGAC
CGAAGCAGTTGTCATCCTTAGTAAGAAACGGTGTCCCTGAAGCTCTTCGAGGAGAAGTCTGGCAGCTGCTAGCAGGCTGTCATAACAATG
ACCACCTGGTAGAGAAATACCGCATTCTTATCACAAAGGAGTCTCCCCAGGACAGTGCTATCACCCGGGATATTAACCGAACATTCCCAG
CCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAATATGCAAGGCTTATTCTGTGTATGATGAAGAGATTG
GTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGAAGAACAGGCATTCAGTGTTCTGGTCAAGATCATGT
TTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAAATTTTACCAGTTGGAGCGCCTCATGCAGGAATACA
TTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGCCTCCCAGTGGTTTCTTACTCTTTTCACTGCAAAAT
TCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAGTGTTATTTTTAATGTCGCCCTTGGATTATTAAAGA
CTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAGGGTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAA
ATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGGACTTTGCCAATACCATTCCTGGCCATGGAGGCATCATGGATCGCTTTGACT
GCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTTATCAGAGGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGA
CTTTACGGCCAGATCAGCAGCTCCACATCTTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACATCCACCACAGAGGACG
AGTAGGGGCCACCCAGGGCCAGGAGAACAGGAACAGAACTGAGCAGGGGCAGGTCTCCAAGGCAAGCCCAGCTGGTGTGACTTAGACAAT
GACGAGGCTTCAACTCACTGTCTTTTTTTTTTTTTTTTGGAGGGTATTTTTTATTTGTGGGTTCAAAAAATCTGTATATACAGTCTATGT
GTTTAGAATTTGTGTTGTAAGTAAACTACAGCTTTGAGTTGGAAAGAAGTCACGGGTTGTAAAACCATTTGGATTTTTTTAAAACAAAAG
TATTAATAATCTGGAAGACAGTGTTGCCCAGGTCAGGAGTGTTTTCTTGGTGGTTCCAGCCCCCATCAATTGAACTGTTTCTGGGCTCAG
TCAGACACAGACATTCATCTGTGTCTGACCAAATCAGGGGACTTCCCCACCTGTGGTGGGAGGCACAGCTTAGATGTTTTGTACACCTGG
TCTTTTCTAGAAATCCCTGCTTGGAGCTGCAGAAGGGTTGCCTTCTGTAGGTCGGAGGAATGGAGGCTTACTAACCAGGTAAGCCTTCTA
TGCATCCACACCAAAATCCTGCAGAATGTAAGTAAGCTCTGCTTTATAAGATGGGTTCACCTTCATCGCAGACTGAAAGTTTCAGTTTTT
ATTTTTTTCAGAAAGCACGAAAAATTATTTATAATAGTCTGGAGAAAAAACACACTGTAATATTTCAAGTGTATGCAGTAGAATGTACTG
TAACTGAGCCCTTTCCCACATGTCTAGGCTCCAATGTCTCCTGTAGGTCCACCTAACTGTGTGTTTTCAGGGACAATGCCATCCATGTTT
GTGCTGTAGACTTGCTGCTGCTGAATCCTTTCTGGGGACTTTCTCATCGGGCAGGGAGCAGAGGGCTTCTCGTTCATGCACCCTTTGCCT
GAACACCCATGTAGCTGCTGTGTTGTGTATATATTACTCTTAAGAGGAGTGTGTGTGTCTGTGTTTGTTTTAAAAGTCACTTATTTCTTA
CAGTGATTTCAATTGCACCATGACTTCTTCACTAAAACCACAAAGTCCTGCTTAAAACTATGGAAAACCTAACCTGATTAGAGCCTTGAC
TATTTTGAAGATTAAATGCACACTTTTTATATAATGTGACCAGTTTAAATGTAGTTTGTATTGTACTGGGGGACCTTTCGTTGTTGTTGT
TTGCTTAAACTGTGATTTTTTTTCCCCTCCCTAATTTCAGGGGTGAGATTGACTTTGGGAAGACAGATTAGTTCTTTGTCAGGCCAACAA
GTGATGGAGTGCGGGAGAGAGAACTTGGCACCCAAATATATCAAACTATTCCGTGCCGTGGATGTTTTCATTGCCAACGAGGGTGTAATG
ATTTGCTTCTGCACCTTGGTCTAGTGCTGGTTTGTGGTGTTTTTGTTTGTAAATTAGCCTCACTGCCTCCCTGAAAGTGCACAGTCAGCC
CAGGTCTCTAGAGTGTCCAGCAGAGGATGGAGCCCTCGGGATGTTTCAGCTCACACATCCTTGAGTGACTTCCCATATGTGTGTGGGGCT
GAAGCGGCTTCTTTCCGCTGAACTTTTATTTCCATTTCAGCCTCGTGGCTTCTCTTATTCAGGTCCAAGGCCCCTTAAAAACAAAACATA
TTATCGCAAGGGCTTTCATTTCAGTATTGGCTGTGTCACTGGCAGGATGCATCACTCTCCAGGGCCTCTTTTTCGGAGCTACTCCCAATT
CCACTCTTCTGTGATTCTGGCTGAGCAAGTTCATGCCGGTAGAGGCTCATTAAGTGAGGTCCTGGGCACCCCCCAAACAGGAAGTGTTTT
CAGGCCCTTACATGCTTATCCTTAAGGTGAGTAGGTATCTCAGCAGCACACCCGAACAGTAAAGGTGATCAATAACGAAACTGTAGTTTT
CAGATTGAAGAATGAACCTGGATCACCAAACTAGATACCGAAAGGGCTCCTCATTTGTCTCTTTTGTCCCATTGTGGGCATATGGTGGGC
TCCTTGAGAGGAGGGAGTCTCAGCTGGGGCCTGGCTGCAGAGACCTGCTCTTGAATAGGGCTGCCTTTGGGATCAGGGAGCCGAGCATAC
TGGGCAAGGCTCATCATGTTCCTTTGTGGAAGTGGTTACTTGGTGGGGGTGGGGTGGGGAAGGGGGGTCTAGGAAGCCGAAGCTGAGTGC
GCACTAGAGCTGCTAGCAGGCAGGCCAGAGGGTCAGCTTGTGTTTTATTTTCTGATTTCTCCTGCATGCTTTCTGGAGATGAGGATTTTT
TGTCAGGTAGCTAGGAGAGCACTGCCACCTTGTGTCCATATAGCACAATGTTTCTCTTTCCTATTCACAGACAAGATTCAAGAAACCATT
TTTACGTGTGTACATTCAAATCTTCATGAATGGCATCACTTGCTTTAGACCCATTTTTTTTTTATTGGTCAGAAATAAAATGTGACTGCA
ACTGTGTGCCCTCCCTTGTCGTGAATTCCCTGTTTATCACTTCCATGCATGGTTTTATGCTTCTCATTTGTTTATGTATTCATGAATACT
GCATAGTCCTGATTCAGAGACTTTTGCTTTGCTTTCCAACTTGTATCCCTACATTCTCACAACAGCCTTCTTACCTCGGGTGAGAGTCAT
GAGCACCTTACCAGGCAGGGAGCTTCCCCAGGATAGTGTGGTGGAGTCAGGACTCACTCCATCCTGCACTTTACCCACAGGACACCTGGA
GGGTCCCCCAGCCCTGCTTGCTTTTGTGAACGTCGTGTGAGTACACCGAGGTGTTGCAGCTTTCCTTCCCTCTAGCTCAGGAGGCCTGGC
CTGAGCCAGGTTGGAGCTTAAATTGCTGTTGGCTCCTGCCTGGTGGAACAAGGGGGTCATAGAAACCAGGGCTGATGGGCACCCCCCAGC
CCCTGGGAGCTCTGCTCATGACCGCTCACAGGGTACCGAGTCTTTGCCTTTTGTGTGTGCGCATGCTGCCCTCTTAACTGCTTTTAGTAT
TCAGAAAGGTTCCATTTATGTTTTACTCCTGAAAGTGAAACCCTCTTAGGCAACTTGTTTCATATTCTGGGCATTTTAGTAGCTACAGTA
TTTTGCATTTAAAATGTAATTACTCTTAGTATTGTACAGCCCTATAATGTATGAGAACTAGTTTCACATCCTTTGAAACTAATCTCTTTC
ATTGGGGAGGATACAACTTTTGACTTTACACAGGTGGACTTTGAATCCATTTTTATAGAATTTTTTTCCACTGTAACTTGACCTATATTA
TGCAAGAAAATCCCAAAAATATGTTTTAAGGGAGACTACACAGACCTTGTGATTTGGTCTGAGCTAGTTGCTGAGTTGACTGGAGCCTTA
TTTGAATGGATCTTTGAGTTGAGATCTTCACACTGTCAGTGAGCCCTTGGCTCAGCCCTTGTCACCTGTTTGTATGGGGACCATGTTTCC
CAAAGCTCAGGTTCATCTCCACTATTGACAGAGTCGGGTAGTGGGAGAGTATAAGTGACTTGAGACAGAGTGTCCTTGCTCAGAAAACTG
TGAAGCAGGGGTCTTGTTAGTTACAAAGCCAGTCCTAGTTGCATGTCCAAGGGGGTAGATTTTCATCACCCTACTAAATGTGGTATGTCA
CTGCTGAAGCCTTTTCCTGTTTTAGTAATATCTTAGGCACTATTGTCTTTTGTCTTCCAGAGTAACATATCTGGGCCCACCTTTCTTGCA
CACTGTGATTATGTGCTAAGAAAAGGGTGGAGTTGGGAGGACAATTTCACTTGAACAGGTTTCTGTTCTTCTGAGGTCAGGGTGGGGAGG
ATGTCCAGGTGACTTTTATGGACACATTGCAAGACAGTAAGCCGCGGATGGACTCTCACTTGTGCTTTGGAACACTGGACTCCAAAGAGC
AGGTGGAACAAACTCTGGCCTGAAGATGATGGCTAATACTCAGGCAGAGCCCCGTATTCTTCCCTGACTTGGTCAAAACAAACTTCCTTT
TCCCTTGATCACCCTGCACGCAGCTGCCCAGCTTCCAGTTTTTAAAGAGATGAACAGCTCTCACTTCCTGACTCAGTTTCTCTTGTTGGG
TGGGGGCCTTGTGCCACAACCTGCATGGGGTGCTAGGGTTTAAACCAAGTGGTCACGAAGGATTCTTATCTCAGGGCTCTGCCTGGCCCA
CCTTCTCTTGGGCCTGGACTCTCCTTATCCACATCCCTGCAGAAGGTGGGCCCTATTCTCAGAAGAGTCCTGGCTGCTGTTGCCATCTGA
ATGCGCCCTTCCCTTTCAGGTTGACCAGCAGTGGCCTTACCTGGCCTCTCAGGTGGATGGAGGCTGTTCTCATCTGGGGCTGTCTCTTGA
TTAAGGCTGTCACCTGTTTGTATAGGGACCATGTTTCCCAACGCACTTTGAGTGCAGTTTAGGAGGTATCCTTTGGATGCTGAAGTGTTG
GGATTTTGAGGACATGCGGATGATTTATGAGAATAGAGGGGCAGAGTTTGTGAAGTCTAGGGTTTTTTGTCCAGTGGGTTTCAAATTTGT
TGGCTGTTTAAAGACCCTGTCTCCTCCCCCACCCTCCCCTTCCTTTTCCCATCAAATGCCTACCTACTGAGGCGCCTTCTCTTTTTATTC
TTGAGCCAATGAGATATCAGTGTGTTTATTAATAAGGATTGCAATAGTATAGTGCTTAATATGTGCCAGGCATAGTGCTAAGGGTTTACA
TACGTTATCCCTTTTAATCCAGAAAACAGCCTTTGATTAGGTATTGTTGTCTCCATTTTATAGATGAGGAAACTGAGGCAGTATGACTGA
GGCCGAGAGCAGTGGTTAAGACAGACTTTGGGATCAAATCACCCTAGGTGCGGGCAGGTTTCTAGGCTGCTCTAAGCTTCTACCTTGAAG
GCAGTTGGGTCTGATAATAGTACCTTCTTCCTGGGGTGGTTGTGAGGATATAACGAGGTAATGCATGTAAGCATTTAGTACCATGCCTGG
CACATAGTAAGCACTCAATAAATGGTAGTTACTTTTGTTGAGCTCAGCTGGTAGTTTGACCTCCGTTGGTGCAATGCCAGAGATGGGATT
GTCAGCCACCACACTGCCACCACCCTGCACACAGTCTGGGTCCCTCCGAGAGAAGCACGCCAACCTTAACATCCCCTACAGCATCTTGGT
GCTTCACACACCATTTAGGAGGCCACCCTAACGAGGCAAGAGGACATGGGGGTGTGCAGAAGTTCTGTTCTTAGTGAGAATGGCTGGCCT
GAGAATCCAGCTCACCTCCTCTGCCCACAGTCTGGACTGCTTGTGGGAAGGCCATCTCCTCCTGTCTGGTGGTACCTCCACTCTGGGCAG
GGAGGGCCTGTCTGTGACTCGCTCTGGACCCCACTTCCCGCTCTGGCCAAGGGCTGTCTTCTGTGCACATAGCTCAGGAGCCTGCAGCAG
TTCCCTGTATGGGTGGATGTCCTCAGGGGCCAAGAAGAGAAGAATGGGGACAACAGAAACCTGCTTTGTAGGGGATTATGTAGACTAAAA
GCCTAGAAGTTCTGCCCACATCCTTATGACGCAGCCAATCTGGAGCTTCATGTTTCCTTCTAAAAGTAGTAACCGGGTAGAAGTGGGTGA
CCCATTGAGGACACATGATGTGAGGTATTTCTGCCGGATTCTAGGTTAGCAAAGACTCAAATGGGTGACTCATGAATGAAGGGAGAACAG
GCACAGGACTTAATGAAAAGAGTTTCTTGAACTTAGTTTTCTGAATGGGGGTGGGGAGTTGGGGCACGTGTGTGTAAGGGGAGGCTGCCT
CACTTTGAAGGAATGGTGTTGGCTAACAGGATCCATGAAATTCCTAGGTCAGTTGAATAATAACTGAACTACTGGTTTGACTGTGGATTA
TTTCCTGGGTATTAGTGGGACCCAACAGCACATTGCTATTAATAGTATGGAAATAATGGTCCCTCTGTTTCATTGAATTGCTGAAGTAAT
GATAATGCCATGAACCAGGAGAAGATGGTTGTGGGGGTTTCTAGGAAGCAGCTGCTGTGACAGGCCAATCCCAGGCTTGCCCCCGAGCCC
TCCTGTCCTTCTGGGTTTGTGTTTGCCTTGCCTGGTGCTTCCTCCCTCATTGTGTTGTTGAATAGACCTAGGCAGCCTTGTATCCATAGA
AAGCCTCCACTGCTGGGCCGGGGAGGGGGTTGTGGTAAGGGCCCTCTGGAAATCAAGCAGAGAATGCCTTTGCAGTGGTCTCCCGGGCAT
TGGGCAGGGCCTAGCCTTTTGCAGCCCCCAGAGGACCTTGCCTGCATAAAGCACTCAGAAGGGTTAGCCACCTGGTGATTTTGTCTCTAG
TGAAACTGTGTTTGCCGATAATCATCCACATAGCCACCTCTGTCCTCGCAGTTTGGATGCCTTTTTTTGACACCTGCGCTAGGTTCTTGT
ATGCTGGCTTTTCTTAAAGGAACAGCAGAGTAGAAAAGAGGTTGAGAATGTTTTCTAGCAGGCAGAATGTGCATACATGTTTTCATGAGT
GTCCTTTGGGTGCTGTTTCTTTTAAATCCTCTGTGCACAGGGCTCTGGCCTTTAGTAAACTGTTTTTCTGTCTTACGTCATGCTGACTGG
GTGCTAGGGGCTGATTACAAAGGGGAAGAGTTGAACAGACATCAGGGGCCGATGAAACCAAAGGACTAGGAGTCAGGAGAACAAGTCAGG
GATTAGGAGACAGCGGTTTGGTTTATTGTTATCCAGCTGGAGGACTCCTAGGGGCAGCAGCAGGAGGAATACCAGGGCCACGGAGGGGCC
AGGAGTCTCACAGTGGAGGGCAGACTCTAACAGATGCCAGCTGAACGCTCGCTGGCCCTGGATGTCATACGAGTTGGGGACCAGAAATCT
GGGCTCAGAGAACCCGTCCAGGGAGATTTGAAGCCATGGGTTATCTTCTAGAGTTGATACTGATAATATATTTTAATTTTTATTGATGTT
TAATACCTTCTGAAACAGGAGGGTAAGATCAGATGGGAAGCCCCTCTGTTGAAGGATCTTGGGAACCTTGGTGGTTTTTTTTTTTTTTTT
GGTTTTTTTTTTTTGATCGAGCTGTGGACATCCTTCTTAATTCGATTCTGAGGATTTGTTTAACTAAAAAGTTCCCAAACACAGAAAGGG
CCTCCCCACCTGCTTTGGGGAGCTGTCTGTGCTGGGAGTGCCAGGCATCCCATGGGACCCATCACTGCCAGTGTCTGTGCCTCCCAGAGG
TCAGCCGTGTCTGCCCTGGCTCTGTCTCCTCTGTGACAGGGCAGAGCATTTCTGGTCAGTTTCTCCATGGTGCCTCCCACCCCTTTGTAA
AGTGGATGGACATGATGGAATTCAGTTGTCTCACCCTGATAGCCTGGGTGTTGATATTCACTTTACCCGCACTCAGACACAGGCGACCTT
GAAGCAGTTCTCGGTGTGTAGAGTCCACGTGACAGTCCCCACAGCCTCCCCAGATAGCTGTGTGCCTGTGCGCTACTGCTGTGCCATTTT
CCCAACTTGGCGTTTCACTAAATGCAGCTGATCTCTCTCTCTGTGCACTCGTGATCCATGTTGAACAATACATGTAGGTTCTTTTTCCAC
GCAATGTAAGAACATGATATACTGTACGTTGGAAAGCATTTACCTTATTTATATACCTGAATGTTCCTACTACACAAATAAACATATATT

>71540_71540_4_RABGAP1-CDS2_RABGAP1_chr9_125839041_ENST00000373647_CDS2_chr20_5170380_ENST00000460006_length(amino acids)=886AA_BP=808
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDG
EGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRS
AKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTE
NFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDS
LYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEA
HMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKDF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RABGAP1-CDS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RABGAP1-CDS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RABGAP1-CDS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource