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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RABGAP1-PBX3 (FusionGDB2 ID:71576)

Fusion Gene Summary for RABGAP1-PBX3

check button Fusion gene summary
Fusion gene informationFusion gene name: RABGAP1-PBX3
Fusion gene ID: 71576
HgeneTgene
Gene symbol

RABGAP1

PBX3

Gene ID

23637

5090

Gene nameRAB GTPase activating protein 1PBX homeobox 3
SynonymsGAPCENA|TBC1D11-
Cytomap

9q33.2-q33.3

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionrab GTPase-activating protein 1GAP and centrosome-associated proteinRab6 GTPase activating protein, GAPCenATBC1 domain family, member 11rab6 GTPase activating protein (GAP and centrosome-associated)rab6 GTPase-activating protein GAPCenApre-B-cell leukemia transcription factor 3homeobox protein PBX3pre-B-cell leukemia homeobox 3
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373647, ENST00000373643, 
ENST00000493854, 		ENST00000538998, 
ENST00000373483, ENST00000447726, 
ENST00000342287, ENST00000373487, 
ENST00000373489, 
Fusion gene scores* DoF score13 X 10 X 7=91010 X 10 X 7=700
# samples 1312
** MAII scorelog2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RABGAP1 [Title/Abstract] AND PBX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRABGAP1(125782738)-PBX3(128691934), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRABGAP1

GO:0043087

regulation of GTPase activity

17562788


check buttonFusion gene breakpoints across RABGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PBX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A82C-01ARABGAP1chr9

125782738

-PBX3chr9

128691934

+
ChimerDB4SKCMTCGA-EB-A82C-01ARABGAP1chr9

125782738

+PBX3chr9

128691934

+


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Fusion Gene ORF analysis for RABGAP1-PBX3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000373647ENST00000538998RABGAP1chr9

125782738

+PBX3chr9

128691934

+
5CDS-5UTRENST00000373647ENST00000373483RABGAP1chr9

125782738

+PBX3chr9

128691934

+
5CDS-5UTRENST00000373647ENST00000447726RABGAP1chr9

125782738

+PBX3chr9

128691934

+
In-frameENST00000373647ENST00000342287RABGAP1chr9

125782738

+PBX3chr9

128691934

+
In-frameENST00000373647ENST00000373487RABGAP1chr9

125782738

+PBX3chr9

128691934

+
In-frameENST00000373647ENST00000373489RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3CDSENST00000373643ENST00000342287RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3CDSENST00000373643ENST00000373487RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3CDSENST00000373643ENST00000373489RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3CDSENST00000493854ENST00000342287RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3CDSENST00000493854ENST00000373487RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3CDSENST00000493854ENST00000373489RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3UTRENST00000373643ENST00000538998RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-3UTRENST00000493854ENST00000538998RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-5UTRENST00000373643ENST00000373483RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-5UTRENST00000373643ENST00000447726RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-5UTRENST00000493854ENST00000373483RABGAP1chr9

125782738

+PBX3chr9

128691934

+
intron-5UTRENST00000493854ENST00000447726RABGAP1chr9

125782738

+PBX3chr9

128691934

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373647RABGAP1chr9125782738+ENST00000342287PBX3chr9128691934+405819281342467777
ENST00000373647RABGAP1chr9125782738+ENST00000373487PBX3chr9128691934+423419281342779881
ENST00000373647RABGAP1chr9125782738+ENST00000373489PBX3chr9128691934+389819281342716860

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373647ENST00000342287RABGAP1chr9125782738+PBX3chr9128691934+0.0001547050.99984527
ENST00000373647ENST00000373487RABGAP1chr9125782738+PBX3chr9128691934+0.0001192410.9998808
ENST00000373647ENST00000373489RABGAP1chr9125782738+PBX3chr9128691934+0.0001301130.9998698

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Fusion Genomic Features for RABGAP1-PBX3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RABGAP1chr9125782738+PBX3chr9128691933+1.01E-070.9999999
RABGAP1chr9125782738+PBX3chr9128691933+1.01E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RABGAP1-PBX3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:125782738/chr9:128691934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRABGAP1chr9:125782738chr9:128691934ENST00000373647+1326142_2985981070.0DomainPID
TgenePBX3chr9:125782738chr9:128691934ENST0000037348318130_1380254.0Compositional biasNote=Poly-Ala
TgenePBX3chr9:125782738chr9:128691934ENST0000044772629130_13897360.0Compositional biasNote=Poly-Ala
TgenePBX3chr9:125782738chr9:128691934ENST0000034228728235_297172764.6666666666666DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:125782738chr9:128691934ENST0000037348318235_2970254.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:125782738chr9:128691934ENST0000037348929235_297172435.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:125782738chr9:128691934ENST0000044772629235_29797360.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr9:125782738chr9:128691934ENST000003734831843_2340254.0DomainPBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRABGAP1chr9:125782738chr9:128691934ENST00000373647+1326798_10475981070.0Coiled coilOntology_term=ECO:0000255
HgeneRABGAP1chr9:125782738chr9:128691934ENST00000373647+1326566_7525981070.0DomainRab-GAP TBC
TgenePBX3chr9:125782738chr9:128691934ENST0000034228728130_138172764.6666666666666Compositional biasNote=Poly-Ala
TgenePBX3chr9:125782738chr9:128691934ENST0000037348929130_138172435.0Compositional biasNote=Poly-Ala
TgenePBX3chr9:125782738chr9:128691934ENST000003422872843_234172764.6666666666666DomainPBC
TgenePBX3chr9:125782738chr9:128691934ENST000003734892943_234172435.0DomainPBC
TgenePBX3chr9:125782738chr9:128691934ENST000004477262943_23497360.0DomainPBC


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Fusion Gene Sequence for RABGAP1-PBX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71576_71576_1_RABGAP1-PBX3_RABGAP1_chr9_125782738_ENST00000373647_PBX3_chr9_128691934_ENST00000342287_length(transcript)=4058nt_BP=1928nt
GGGGACAGGGCGGTTTGGGAGGCCCAGGCGGCGGAGCCTCCGGGACGGCGAGCGGCGGGCGGCGGAGGAGGAGACGGCAGGTCGGGCATT
AAAAAATATTTAATCATTCATGTGTTGAGACTCATTCTTGAGTTATGGATGACAAGGCTTCTGTTGGAAAAATCAGTGTCTCTTCAGACT
CAGTATCTACTCTTAATAGTGAAGATTTTGTCTTGGTTTCCAGGCAAGGAGATGAGACACCATCTACAAATAATGGAAGTGATGATGAGA
AAACAGGACTCAAGATTGTAGGGAATGGAAGTGAACAGCAGCTGCAAAAAGAGCTAGCAGATGTACTGATGGATCCTCCAATGGACGACC
AGCCAGGGGAAAAGGAGCTTGTGAAAAGGTCACAACTGGATGGTGAAGGAGATGGGCCTCTTTCTAATCAGCTCTCCGCTTCATCCACCA
TTAACCCTGTGCCATTAGTAGGGCTCCAAAAACCAGAGATGAGCCTACCAGTGAAACCTGGACAAGGAGATTCTGAAGCTTCAAGTCCTT
TCACACCAGTGGCCGATGAGGACAGCGTAGTTTTCAGTAAACTGACTTACTTAGGCTGTGCCTCGGTAAATGCTCCCAGGAGTGAAGTGG
AAGCCTTAAGGATGATGTCCATCTTAAGAAGCCAGTGTCAGATTTCACTAGATGTTACCCTTTCAGTGCCGAATGTGTCTGAAGGAATTG
TGAGACTCTTAGATCCTCAGACAAACACTGAAATAGCAAACTACCCTATCTACAAAATCCTCTTCTGTGTCAGAGGGCATGATGGAACTC
CTGAGAGTGACTGTTTTGCTTTCACTGAAAGTCATTACAATGCAGAGCTCTTCAGAATACACGTCTTCCGGTGTGAAATACAAGAAGCTG
TAAGCCGGATACTTTACAGTTTTGCCACTGCCTTCCGCCGTTCTGCCAAGCAGACCCCACTTTCAGCCACTGCTGCACCCCAGACTCCTG
ACAGTGACATCTTTACCTTCTCTGTGTCTTTAGAAATAAAAGAAGATGATGGTAAAGGTTATTTTAGTGCAGTTCCCAAAGATAAGGACA
GACAGTGCTTTAAACTACGCCAAGGAATTGATAAGAAGATTGTCATCTATGTGCAGCAAACAACTAATAAAGAACTTGCCATTGAAAGGT
GTTTTGGTCTTCTCCTTAGTCCAGGAAAAGATGTACGAAATAGTGACATGCACTTATTAGATTTGGAATCTATGGGCAAAAGTTCAGATG
GAAAGTCGTATGTTATTACGGGGAGCTGGAATCCAAAATCCCCACATTTTCAAGTTGTAAATGAAGAAACTCCTAAAGATAAAGTCCTGT
TTATGACCACAGCTGTAGATTTGGTAATAACAGAAGTACAGGAGCCTGTTCGATTTCTCCTGGAGACAAAAGTCCGCGTTTGCTCACCTA
ATGAAAGATTATTCTGGCCCTTCAGCAAACGTAGTACTACTGAAAATTTCTTTTTGAAACTAAAACAGATAAAGCAAAGGGAGAGAAAGA
ATAATACTGACACTTTATATGAAGTTGTATGCTTGGAAAGTGAATCAGAAAGAGAGAGGAGGAAAACTACAGCCAGTCCTTCAGTTCGCC
TGCCACAGTCTGGATCGCAAAGTTCAGTGATACCTTCTCCTCCAGAAGATGATGAAGAGGAAGATAATGATGAACCTCTCCTGAGTGGAT
CTGGTGATGTATCCAAAGAATGTGCAGAAAAAATTCTTGAAACATGGGGAGAACTGTTGTCAAAATGGCATCTCAACTTGAATGTGAGAC
CGAAGCAGTTGTCATCCTTAGTAAGAAACGGTGTCCCTGAAGCTCTTCGAGGAGAAGTCTGGCAGCTGCTAGCAGGCTGTCATAACAATG
ACCACCTGGTAGAGAAATACCGCATTCTTATCACAAAGGCATGTAATGAATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTA
GAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAA
GCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCT
TGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGT
CACAGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAA
AGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAATTCCGGTGGATACC
CTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGA
GGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTG
GCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACA
GCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACA
CAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTAT
CAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGC
AGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGT
TGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTA
TAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATT
GTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACA
GACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTAT
ACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCT
CACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATA
AAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTA
ATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTGAATGTTCTTCATCTTATTACTAATCCATGCAAAAAAAAAAA
AAAAAGCAGCGACTAATTGTGATGCATTCAGATTTCAGTATTCAGTACTGTATATTTCACCCTGTGTAATGGGGCCCCCTCTCCTTTCTC
TCTTTTTGTATTGTATGCGATTCTGAAACTGATTGAGTCATGAAAATAATTTGTGGCGGTGATTCTAATGTATTAAAAACGTTTCGTGTT
CCTTTCTAACTGGATTACACCCTGGATTGAAAAAGTCTTCCTCGTGGTAGTTATATGTAGTTTCAAACATGAATAAACTTTTTGCTTTCA

>71576_71576_1_RABGAP1-PBX3_RABGAP1_chr9_125782738_ENST00000373647_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=777AA_BP=0
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDG
EGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRS
AKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTE
NFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKACNEFTTHVMNLLREQSRTRPISPKEIERMVG
IIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYK

--------------------------------------------------------------
>71576_71576_2_RABGAP1-PBX3_RABGAP1_chr9_125782738_ENST00000373647_PBX3_chr9_128691934_ENST00000373487_length(transcript)=4234nt_BP=1928nt
GGGGACAGGGCGGTTTGGGAGGCCCAGGCGGCGGAGCCTCCGGGACGGCGAGCGGCGGGCGGCGGAGGAGGAGACGGCAGGTCGGGCATT
AAAAAATATTTAATCATTCATGTGTTGAGACTCATTCTTGAGTTATGGATGACAAGGCTTCTGTTGGAAAAATCAGTGTCTCTTCAGACT
CAGTATCTACTCTTAATAGTGAAGATTTTGTCTTGGTTTCCAGGCAAGGAGATGAGACACCATCTACAAATAATGGAAGTGATGATGAGA
AAACAGGACTCAAGATTGTAGGGAATGGAAGTGAACAGCAGCTGCAAAAAGAGCTAGCAGATGTACTGATGGATCCTCCAATGGACGACC
AGCCAGGGGAAAAGGAGCTTGTGAAAAGGTCACAACTGGATGGTGAAGGAGATGGGCCTCTTTCTAATCAGCTCTCCGCTTCATCCACCA
TTAACCCTGTGCCATTAGTAGGGCTCCAAAAACCAGAGATGAGCCTACCAGTGAAACCTGGACAAGGAGATTCTGAAGCTTCAAGTCCTT
TCACACCAGTGGCCGATGAGGACAGCGTAGTTTTCAGTAAACTGACTTACTTAGGCTGTGCCTCGGTAAATGCTCCCAGGAGTGAAGTGG
AAGCCTTAAGGATGATGTCCATCTTAAGAAGCCAGTGTCAGATTTCACTAGATGTTACCCTTTCAGTGCCGAATGTGTCTGAAGGAATTG
TGAGACTCTTAGATCCTCAGACAAACACTGAAATAGCAAACTACCCTATCTACAAAATCCTCTTCTGTGTCAGAGGGCATGATGGAACTC
CTGAGAGTGACTGTTTTGCTTTCACTGAAAGTCATTACAATGCAGAGCTCTTCAGAATACACGTCTTCCGGTGTGAAATACAAGAAGCTG
TAAGCCGGATACTTTACAGTTTTGCCACTGCCTTCCGCCGTTCTGCCAAGCAGACCCCACTTTCAGCCACTGCTGCACCCCAGACTCCTG
ACAGTGACATCTTTACCTTCTCTGTGTCTTTAGAAATAAAAGAAGATGATGGTAAAGGTTATTTTAGTGCAGTTCCCAAAGATAAGGACA
GACAGTGCTTTAAACTACGCCAAGGAATTGATAAGAAGATTGTCATCTATGTGCAGCAAACAACTAATAAAGAACTTGCCATTGAAAGGT
GTTTTGGTCTTCTCCTTAGTCCAGGAAAAGATGTACGAAATAGTGACATGCACTTATTAGATTTGGAATCTATGGGCAAAAGTTCAGATG
GAAAGTCGTATGTTATTACGGGGAGCTGGAATCCAAAATCCCCACATTTTCAAGTTGTAAATGAAGAAACTCCTAAAGATAAAGTCCTGT
TTATGACCACAGCTGTAGATTTGGTAATAACAGAAGTACAGGAGCCTGTTCGATTTCTCCTGGAGACAAAAGTCCGCGTTTGCTCACCTA
ATGAAAGATTATTCTGGCCCTTCAGCAAACGTAGTACTACTGAAAATTTCTTTTTGAAACTAAAACAGATAAAGCAAAGGGAGAGAAAGA
ATAATACTGACACTTTATATGAAGTTGTATGCTTGGAAAGTGAATCAGAAAGAGAGAGGAGGAAAACTACAGCCAGTCCTTCAGTTCGCC
TGCCACAGTCTGGATCGCAAAGTTCAGTGATACCTTCTCCTCCAGAAGATGATGAAGAGGAAGATAATGATGAACCTCTCCTGAGTGGAT
CTGGTGATGTATCCAAAGAATGTGCAGAAAAAATTCTTGAAACATGGGGAGAACTGTTGTCAAAATGGCATCTCAACTTGAATGTGAGAC
CGAAGCAGTTGTCATCCTTAGTAAGAAACGGTGTCCCTGAAGCTCTTCGAGGAGAAGTCTGGCAGCTGCTAGCAGGCTGTCATAACAATG
ACCACCTGGTAGAGAAATACCGCATTCTTATCACAAAGGCATGTAATGAATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTA
GAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAA
GCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCT
TGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGT
CACAGAGTCTTGTAAAGGATCCAAAAGAAAGAGGGAGCAAAGGTTCTGACATCCAGCCAACTAGCGTGGTATCCAATTGGTTTGGCAACA
AACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAAAGACGGCCGTGACAGCTGCACACGCAG
TAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAATTCCGGTTCTTCTGGTTCTTTTAACCTCCCAAATTCTGGGG
ACATGTTCATGAACATGCAGAGTCTGAATGGGGATTCTTACCAAGGGTCCCAAGTCGGAGCCAATGTGCAATCACAGGTGGATACCCTCC
GTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTCCACATAATTTAAATGCTAATGGAGGCT
GGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACTCGGATACCTCTAACTAATCTCTGGCCA
CACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGCGTTTTTGTAGCCCACCATCTACAGCTT
TACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCATTTGTATTTATACTTAAAAACACACAAT
GTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTAGCTATTTTATCATAATTTATTATCAAT
ATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATACACTAAACCTCAACCGTTAAAGCAGAT
GCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCTTTCTTTCATATCACTAATGGAGTTGGA
ATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGTTTGTGTTCAGATCTCTTATGTTATAAT
TAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGGTAATAAAATTATGGATCCAGATTGTTC
TGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTACGGTGTGCACTGGGTGCTGCACAGACT
TGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATATAGTGTAGCAAAAGAGTATTTATACAT
CCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAACATGTTCTGTAGCTTAGAGTGCTCACT
TACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAATTAACTCTTTGTTTCCCTTCATAAAAT
GTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACCGAGTGTGGAAACATTGGGTCTTAATTC
AACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTGAATGTTCTTCATCTTATTACTAATCCATGCAAAAAAAAAAAAAAA
AGCAGCGACTAATTGTGATGCATTCAGATTTCAGTATTCAGTACTGTATATTTCACCCTGTGTAATGGGGCCCCCTCTCCTTTCTCTCTT
TTTGTATTGTATGCGATTCTGAAACTGATTGAGTCATGAAAATAATTTGTGGCGGTGATTCTAATGTATTAAAAACGTTTCGTGTTCCTT
TCTAACTGGATTACACCCTGGATTGAAAAAGTCTTCCTCGTGGTAGTTATATGTAGTTTCAAACATGAATAAACTTTTTGCTTTCATGAT

>71576_71576_2_RABGAP1-PBX3_RABGAP1_chr9_125782738_ENST00000373647_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=881AA_BP=0
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDG
EGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRS
AKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTE
NFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKACNEFTTHVMNLLREQSRTRPISPKEIERMVG
IIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKG
SDIQPTSVVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQ

--------------------------------------------------------------
>71576_71576_3_RABGAP1-PBX3_RABGAP1_chr9_125782738_ENST00000373647_PBX3_chr9_128691934_ENST00000373489_length(transcript)=3898nt_BP=1928nt
GGGGACAGGGCGGTTTGGGAGGCCCAGGCGGCGGAGCCTCCGGGACGGCGAGCGGCGGGCGGCGGAGGAGGAGACGGCAGGTCGGGCATT
AAAAAATATTTAATCATTCATGTGTTGAGACTCATTCTTGAGTTATGGATGACAAGGCTTCTGTTGGAAAAATCAGTGTCTCTTCAGACT
CAGTATCTACTCTTAATAGTGAAGATTTTGTCTTGGTTTCCAGGCAAGGAGATGAGACACCATCTACAAATAATGGAAGTGATGATGAGA
AAACAGGACTCAAGATTGTAGGGAATGGAAGTGAACAGCAGCTGCAAAAAGAGCTAGCAGATGTACTGATGGATCCTCCAATGGACGACC
AGCCAGGGGAAAAGGAGCTTGTGAAAAGGTCACAACTGGATGGTGAAGGAGATGGGCCTCTTTCTAATCAGCTCTCCGCTTCATCCACCA
TTAACCCTGTGCCATTAGTAGGGCTCCAAAAACCAGAGATGAGCCTACCAGTGAAACCTGGACAAGGAGATTCTGAAGCTTCAAGTCCTT
TCACACCAGTGGCCGATGAGGACAGCGTAGTTTTCAGTAAACTGACTTACTTAGGCTGTGCCTCGGTAAATGCTCCCAGGAGTGAAGTGG
AAGCCTTAAGGATGATGTCCATCTTAAGAAGCCAGTGTCAGATTTCACTAGATGTTACCCTTTCAGTGCCGAATGTGTCTGAAGGAATTG
TGAGACTCTTAGATCCTCAGACAAACACTGAAATAGCAAACTACCCTATCTACAAAATCCTCTTCTGTGTCAGAGGGCATGATGGAACTC
CTGAGAGTGACTGTTTTGCTTTCACTGAAAGTCATTACAATGCAGAGCTCTTCAGAATACACGTCTTCCGGTGTGAAATACAAGAAGCTG
TAAGCCGGATACTTTACAGTTTTGCCACTGCCTTCCGCCGTTCTGCCAAGCAGACCCCACTTTCAGCCACTGCTGCACCCCAGACTCCTG
ACAGTGACATCTTTACCTTCTCTGTGTCTTTAGAAATAAAAGAAGATGATGGTAAAGGTTATTTTAGTGCAGTTCCCAAAGATAAGGACA
GACAGTGCTTTAAACTACGCCAAGGAATTGATAAGAAGATTGTCATCTATGTGCAGCAAACAACTAATAAAGAACTTGCCATTGAAAGGT
GTTTTGGTCTTCTCCTTAGTCCAGGAAAAGATGTACGAAATAGTGACATGCACTTATTAGATTTGGAATCTATGGGCAAAAGTTCAGATG
GAAAGTCGTATGTTATTACGGGGAGCTGGAATCCAAAATCCCCACATTTTCAAGTTGTAAATGAAGAAACTCCTAAAGATAAAGTCCTGT
TTATGACCACAGCTGTAGATTTGGTAATAACAGAAGTACAGGAGCCTGTTCGATTTCTCCTGGAGACAAAAGTCCGCGTTTGCTCACCTA
ATGAAAGATTATTCTGGCCCTTCAGCAAACGTAGTACTACTGAAAATTTCTTTTTGAAACTAAAACAGATAAAGCAAAGGGAGAGAAAGA
ATAATACTGACACTTTATATGAAGTTGTATGCTTGGAAAGTGAATCAGAAAGAGAGAGGAGGAAAACTACAGCCAGTCCTTCAGTTCGCC
TGCCACAGTCTGGATCGCAAAGTTCAGTGATACCTTCTCCTCCAGAAGATGATGAAGAGGAAGATAATGATGAACCTCTCCTGAGTGGAT
CTGGTGATGTATCCAAAGAATGTGCAGAAAAAATTCTTGAAACATGGGGAGAACTGTTGTCAAAATGGCATCTCAACTTGAATGTGAGAC
CGAAGCAGTTGTCATCCTTAGTAAGAAACGGTGTCCCTGAAGCTCTTCGAGGAGAAGTCTGGCAGCTGCTAGCAGGCTGTCATAACAATG
ACCACCTGGTAGAGAAATACCGCATTCTTATCACAAAGGCATGTAATGAATTTACTACACATGTGATGAACCTTCTCCGAGAACAGAGTA
GAACACGTCCCATTTCTCCAAAAGAGATTGAAAGAATGGTGGGCATCATCCATCGAAAATTTAGTTCCATTCAGATGCAGCTCAAACAAA
GCACTTGTGAAGCAGTTATGATTTTAAGATCAAGGTTCCTTGATGCCAGACGGAAAAGGCGTAACTTCAGTAAACAGGCCACAGAAATCT
TGAATGAATATTTTTACTCACACCTCAGCAACCCCTACCCCAGTGAAGAAGCCAAAGAGGAGCTGGCCAAGAAATGCAGCATCACAGTGT
CACAGGTATCCAATTGGTTTGGCAACAAACGAATCAGGTACAAGAAGAACATTGGCAAGTTTCAGGAAGAAGCCAACCTCTATGCTGCAA
AGACGGCCGTGACAGCTGCACACGCAGTAGCAGCAGCTGTGCAGAACAACCAGACCAATTCGCCCACCACACCAAATTCCGGTTCTTCTG
GTTCTTTTAACCTCCCAAATTCTGGGGACATGTTCATGAACATGCAGAGTCTGAATGGGGATTCTTACCAAGGGTCCCAAGTCGGAGCCA
ATGTGCAATCACAGGTGGATACCCTCCGTCATGTTATCAATCAGACGGGAGGCTACAGTGATGGCCTTGGAGGAAATTCACTGTACAGTC
CACATAATTTAAATGCTAATGGAGGCTGGCAGGACGCAACAACTCCATCTTCTGTGACTTCTCCTACAGAAGGCCCAGGAAGTGTGCACT
CGGATACCTCTAACTAATCTCTGGCCACACTTTTCCCTGAGCTACATGCCTTGATAAGTGCATTCAGAGCAATAGGAGGAAAAGGAAAGC
GTTTTTGTAGCCCACCATCTACAGCTTTACTGTAAAACCTTGTCTTATTCGAGAACTTGGTAAATCTGTTTTTTAAGGAATCATAATCAT
TTGTATTTATACTTAAAAACACACAATGTTAAAAAAAATAAAGCACTTTATCCAATTAGGCCAAGATTTAACATTGTTGACAGTCCTGTA
GCTATTTTATCATAATTTATTATCAATATTTTACATTAATGGTTTCACAGTTGCCAATTACTTGGCCTTAAGGGTAAAAAGTACAATATA
CACTAAACCTCAACCGTTAAAGCAGATGCAAAAATTCACCTCACCTAAATTGAACTTCTTGCATATTTCCATTACTGACTTGGATTGTCT
TTCTTTCATATCACTAATGGAGTTGGAATAAAGAGCTGTTTGCCTATCCCTGTTAATGATGGTTGTGTTTAAGAATCTTCCTCGTCACGT
TTGTGTTCAGATCTCTTATGTTATAATTAGATCAGAGACTGGTAGCATCGTTTCTCTCTCTGAAAGCACCAGTGCCCAGAGTCTGCTCGG
TAATAAAATTATGGATCCAGATTGTTCTGAGAGACGAAGATACTTGCTGCTGATAGAGGTGAAAACGAGATTGATCCGTCTGGGGTTTTA
CGGTGTGCACTGGGTGCTGCACAGACTTGTCAAGGTTTGCTACGTCCTCTGGGCATCTGCAAAAGGCCCTGCTCTCTGGAGTGTTGTATA
TAGTGTAGCAAAAGAGTATTTATACATCCCACCAATCAAAACACAGCTTTATTACCTCATGCGAACTCATACAAACCAATAGAATTTCAA
CATGTTCTGTAGCTTAGAGTGCTCACTTACTACCTCTGAACAATACTCACGCTGTAGTTTGTCTCTTTCTTATCTTTTTGCATCTTGTAA
TTAACTCTTTGTTTCCCTTCATAAAATGTAATGTACATTGTAATCTTTTAAAAGAAAAATCAGGGTTGCACTTGCAACTTTTAAAAAACC
GAGTGTGGAAACATTGGGTCTTAATTCAACACAGGATCGGTAAAACTGTTGTAAATACTGAGAAACATTTTGAATGTTCTTCATCTTATT

>71576_71576_3_RABGAP1-PBX3_RABGAP1_chr9_125782738_ENST00000373647_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=860AA_BP=0
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDDQPGEKELVKRSQLDG
EGDGPLSNQLSASSTINPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRS
AKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTE
NFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKACNEFTTHVMNLLREQSRTRPISPKEIERMVG
IIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYK
KNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RABGAP1-PBX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RABGAP1-PBX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RABGAP1-PBX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource