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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASL-GUSB (FusionGDB2 ID:7161)

Fusion Gene Summary for ASL-GUSB

check button Fusion gene summary
Fusion gene informationFusion gene name: ASL-GUSB
Fusion gene ID: 7161
HgeneTgene
Gene symbol

ASL

GUSB

Gene ID

435

2990

Gene nameargininosuccinate lyaseglucuronidase beta
SynonymsASALBG|MPS7
Cytomap

7q11.21

7q11.21

Type of geneprotein-codingprotein-coding
Descriptionargininosuccinate lyaseargininosuccinasearginosuccinasebeta-glucuronidasebeta-D-glucuronidasebeta-G1
Modification date2020031320200313
UniProtAcc.

Q6P575

Ensembl transtripts involved in fusion geneENST00000304874, ENST00000380839, 
ENST00000395331, ENST00000395332, 
ENST00000464970, 		ENST00000476486, 
ENST00000304895, ENST00000345660, 
ENST00000421103, 
Fusion gene scores* DoF score4 X 2 X 4=326 X 4 X 4=96
# samples 47
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASL [Title/Abstract] AND GUSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASL(65541080)-GUSB(65432894), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ASL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GUSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5RW-01AASLchr7

65541080

+GUSBchr7

65432894

-


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Fusion Gene ORF analysis for ASL-GUSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000304874ENST00000476486ASLchr7

65541080

+GUSBchr7

65432894

-
5CDS-intronENST00000380839ENST00000476486ASLchr7

65541080

+GUSBchr7

65432894

-
5CDS-intronENST00000395331ENST00000476486ASLchr7

65541080

+GUSBchr7

65432894

-
5CDS-intronENST00000395332ENST00000476486ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000304874ENST00000304895ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000304874ENST00000345660ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000304874ENST00000421103ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000380839ENST00000304895ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000380839ENST00000345660ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000380839ENST00000421103ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000395331ENST00000304895ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000395331ENST00000345660ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000395331ENST00000421103ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000395332ENST00000304895ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000395332ENST00000345660ASLchr7

65541080

+GUSBchr7

65432894

-
In-frameENST00000395332ENST00000421103ASLchr7

65541080

+GUSBchr7

65432894

-
intron-3CDSENST00000464970ENST00000304895ASLchr7

65541080

+GUSBchr7

65432894

-
intron-3CDSENST00000464970ENST00000345660ASLchr7

65541080

+GUSBchr7

65432894

-
intron-3CDSENST00000464970ENST00000421103ASLchr7

65541080

+GUSBchr7

65432894

-
intron-intronENST00000464970ENST00000476486ASLchr7

65541080

+GUSBchr7

65432894

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304874ASLchr765541080+ENST00000304895GUSBchr765432894-80711415593192
ENST00000304874ASLchr765541080+ENST00000421103GUSBchr765432894-79011415593192
ENST00000304874ASLchr765541080+ENST00000345660GUSBchr765432894-79011415593192
ENST00000380839ASLchr765541080+ENST00000304895GUSBchr765432894-921228132707191
ENST00000380839ASLchr765541080+ENST00000421103GUSBchr765432894-904228132707191
ENST00000380839ASLchr765541080+ENST00000345660GUSBchr765432894-904228132707191
ENST00000395332ASLchr765541080+ENST00000304895GUSBchr765432894-913220124699191
ENST00000395332ASLchr765541080+ENST00000421103GUSBchr765432894-896220124699191
ENST00000395332ASLchr765541080+ENST00000345660GUSBchr765432894-896220124699191
ENST00000395331ASLchr765541080+ENST00000304895GUSBchr765432894-903210114689191
ENST00000395331ASLchr765541080+ENST00000421103GUSBchr765432894-886210114689191
ENST00000395331ASLchr765541080+ENST00000345660GUSBchr765432894-886210114689191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304874ENST00000304895ASLchr765541080+GUSBchr765432894-0.0042989940.995701
ENST00000304874ENST00000421103ASLchr765541080+GUSBchr765432894-0.0038309860.99616903
ENST00000304874ENST00000345660ASLchr765541080+GUSBchr765432894-0.0038309860.99616903
ENST00000380839ENST00000304895ASLchr765541080+GUSBchr765432894-0.0054658840.99453413
ENST00000380839ENST00000421103ASLchr765541080+GUSBchr765432894-0.0043682390.9956318
ENST00000380839ENST00000345660ASLchr765541080+GUSBchr765432894-0.0043682390.9956318
ENST00000395332ENST00000304895ASLchr765541080+GUSBchr765432894-0.0052794130.9947206
ENST00000395332ENST00000421103ASLchr765541080+GUSBchr765432894-0.0043185080.9956815
ENST00000395332ENST00000345660ASLchr765541080+GUSBchr765432894-0.0043185080.9956815
ENST00000395331ENST00000304895ASLchr765541080+GUSBchr765432894-0.0045524730.99544746
ENST00000395331ENST00000421103ASLchr765541080+GUSBchr765432894-0.0039792380.99602073
ENST00000395331ENST00000345660ASLchr765541080+GUSBchr765432894-0.0039792380.99602073

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Fusion Genomic Features for ASL-GUSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ASL-GUSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:65541080/chr7:65432894)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GUSB

Q6P575

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ASL-GUSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7161_7161_1_ASL-GUSB_ASL_chr7_65541080_ENST00000304874_GUSB_chr7_65432894_ENST00000304895_length(transcript)=807nt_BP=114nt
CCGGCCAGAAAAGCCCTGGCCAGTGGCGGGCGCGACACTATCCGTGCGGCCAGGCGGAGACCCGGAGGACCGAAGCTTCCGGACGACGAG
GAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGACTACGGGCACCTG
GAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGAGCAGAA
ACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGTCTGGAT
CAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGAGTGCTGGGGAAT
AAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAAACCAGG
TATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTCCTCCCC
GAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTGTGGTCA

>7161_7161_1_ASL-GUSB_ASL_chr7_65541080_ENST00000304874_GUSB_chr7_65432894_ENST00000304895_length(amino acids)=192AA_BP=31
MASGGRDTIRAARRRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGF
HQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSV

--------------------------------------------------------------
>7161_7161_2_ASL-GUSB_ASL_chr7_65541080_ENST00000304874_GUSB_chr7_65432894_ENST00000345660_length(transcript)=790nt_BP=114nt
CCGGCCAGAAAAGCCCTGGCCAGTGGCGGGCGCGACACTATCCGTGCGGCCAGGCGGAGACCCGGAGGACCGAAGCTTCCGGACGACGAG
GAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGACTACGGGCACCTG
GAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGAGCAGAA
ACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGTCTGGAT
CAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGAGTGCTGGGGAAT
AAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAAACCAGG
TATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTCCTCCCC
GAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTGTGGTCA

>7161_7161_2_ASL-GUSB_ASL_chr7_65541080_ENST00000304874_GUSB_chr7_65432894_ENST00000345660_length(amino acids)=192AA_BP=31
MASGGRDTIRAARRRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGF
HQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSV

--------------------------------------------------------------
>7161_7161_3_ASL-GUSB_ASL_chr7_65541080_ENST00000304874_GUSB_chr7_65432894_ENST00000421103_length(transcript)=790nt_BP=114nt
CCGGCCAGAAAAGCCCTGGCCAGTGGCGGGCGCGACACTATCCGTGCGGCCAGGCGGAGACCCGGAGGACCGAAGCTTCCGGACGACGAG
GAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGACTACGGGCACCTG
GAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGAGCAGAA
ACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGTCTGGAT
CAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGAGTGCTGGGGAAT
AAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAAACCAGG
TATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTCCTCCCC
GAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTGTGGTCA

>7161_7161_3_ASL-GUSB_ASL_chr7_65541080_ENST00000304874_GUSB_chr7_65432894_ENST00000421103_length(amino acids)=192AA_BP=31
MASGGRDTIRAARRRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGF
HQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSV

--------------------------------------------------------------
>7161_7161_4_ASL-GUSB_ASL_chr7_65541080_ENST00000380839_GUSB_chr7_65432894_ENST00000304895_length(transcript)=921nt_BP=228nt
CGGCGGCCGGATGGGCGGGACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAA
GCGCAGTGCCCAGAACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGA
GGACCGAAGCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCT
TGGTATCACGACTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATT
ATTCAGAGCGAGTATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTA
GAGCAGTACCATCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAG
TCACCGACGAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATAC
TGGAAGATTGCCAATGAAACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATA
CCACCTGCGTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACG
TTTCTGGCCTGGGTTTTGTGGTCATCTATTCTAGCAGGGAACACTAAAGGTGGAAATAAAAGATTTTCTATTATGGAAATAAAGAGTTGG

>7161_7161_4_ASL-GUSB_ASL_chr7_65541080_ENST00000380839_GUSB_chr7_65432894_ENST00000304895_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_5_ASL-GUSB_ASL_chr7_65541080_ENST00000380839_GUSB_chr7_65432894_ENST00000345660_length(transcript)=904nt_BP=228nt
CGGCGGCCGGATGGGCGGGACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAA
GCGCAGTGCCCAGAACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGA
GGACCGAAGCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCT
TGGTATCACGACTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATT
ATTCAGAGCGAGTATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTA
GAGCAGTACCATCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAG
TCACCGACGAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATAC
TGGAAGATTGCCAATGAAACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATA
CCACCTGCGTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACG
TTTCTGGCCTGGGTTTTGTGGTCATCTATTCTAGCAGGGAACACTAAAGGTGGAAATAAAAGATTTTCTATTATGGAAATAAAGAGTTGG

>7161_7161_5_ASL-GUSB_ASL_chr7_65541080_ENST00000380839_GUSB_chr7_65432894_ENST00000345660_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_6_ASL-GUSB_ASL_chr7_65541080_ENST00000380839_GUSB_chr7_65432894_ENST00000421103_length(transcript)=904nt_BP=228nt
CGGCGGCCGGATGGGCGGGACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAA
GCGCAGTGCCCAGAACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGA
GGACCGAAGCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCT
TGGTATCACGACTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATT
ATTCAGAGCGAGTATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTA
GAGCAGTACCATCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAG
TCACCGACGAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATAC
TGGAAGATTGCCAATGAAACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATA
CCACCTGCGTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACG
TTTCTGGCCTGGGTTTTGTGGTCATCTATTCTAGCAGGGAACACTAAAGGTGGAAATAAAAGATTTTCTATTATGGAAATAAAGAGTTGG

>7161_7161_6_ASL-GUSB_ASL_chr7_65541080_ENST00000380839_GUSB_chr7_65432894_ENST00000421103_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_7_ASL-GUSB_ASL_chr7_65541080_ENST00000395331_GUSB_chr7_65432894_ENST00000304895_length(transcript)=903nt_BP=210nt
GACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTGCCCAGAACTC
GGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGAGGACCGAAGCTTCCGGAC
GACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGACTACGGG
CACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGA
GCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGT
CTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGAGTGCTG
GGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAA
ACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTC
CTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTG
TGGTCATCTATTCTAGCAGGGAACACTAAAGGTGGAAATAAAAGATTTTCTATTATGGAAATAAAGAGTTGGCATGAAAGTGGCTACTGA

>7161_7161_7_ASL-GUSB_ASL_chr7_65541080_ENST00000395331_GUSB_chr7_65432894_ENST00000304895_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_8_ASL-GUSB_ASL_chr7_65541080_ENST00000395331_GUSB_chr7_65432894_ENST00000345660_length(transcript)=886nt_BP=210nt
GACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTGCCCAGAACTC
GGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGAGGACCGAAGCTTCCGGAC
GACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGACTACGGG
CACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGA
GCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGT
CTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGAGTGCTG
GGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAA
ACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTC
CTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTG

>7161_7161_8_ASL-GUSB_ASL_chr7_65541080_ENST00000395331_GUSB_chr7_65432894_ENST00000345660_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_9_ASL-GUSB_ASL_chr7_65541080_ENST00000395331_GUSB_chr7_65432894_ENST00000421103_length(transcript)=886nt_BP=210nt
GACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTGCCCAGAACTC
GGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGAGGACCGAAGCTTCCGGAC
GACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGACTACGGG
CACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGA
GCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGT
CTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGAGTGCTG
GGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAA
ACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGCGTGTCCCTTC
CTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTG

>7161_7161_9_ASL-GUSB_ASL_chr7_65541080_ENST00000395331_GUSB_chr7_65432894_ENST00000421103_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_10_ASL-GUSB_ASL_chr7_65541080_ENST00000395332_GUSB_chr7_65432894_ENST00000304895_length(transcript)=913nt_BP=220nt
GGATGGGCGGGACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTG
CCCAGAACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGAGGACCGAA
GCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCA
CGACTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAG
CGAGTATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTA
CCATCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGAC
GAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGAT
TGCCAATGAAACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGC
GTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGC
CTGGGTTTTGTGGTCATCTATTCTAGCAGGGAACACTAAAGGTGGAAATAAAAGATTTTCTATTATGGAAATAAAGAGTTGGCATGAAAG

>7161_7161_10_ASL-GUSB_ASL_chr7_65541080_ENST00000395332_GUSB_chr7_65432894_ENST00000304895_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_11_ASL-GUSB_ASL_chr7_65541080_ENST00000395332_GUSB_chr7_65432894_ENST00000345660_length(transcript)=896nt_BP=220nt
GGATGGGCGGGACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTG
CCCAGAACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGAGGACCGAA
GCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCA
CGACTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAG
CGAGTATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTA
CCATCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGAC
GAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGAT
TGCCAATGAAACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGC
GTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGC

>7161_7161_11_ASL-GUSB_ASL_chr7_65541080_ENST00000395332_GUSB_chr7_65432894_ENST00000345660_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------
>7161_7161_12_ASL-GUSB_ASL_chr7_65541080_ENST00000395332_GUSB_chr7_65432894_ENST00000421103_length(transcript)=896nt_BP=220nt
GGATGGGCGGGACGGGCGTGGAGGACGCCGAGCACCGTGGCGCGCGCTCACGTCCGCGTCCCCAAGGGCTGCGCTCCCTCAAGCGCAGTG
CCCAGAACTCGGAGCCAGCCCGGCCCGGGGGACCCTGCTGGCCAAGGAGGTCGTCAGTCCGGTCTTGTCTTCCAGACCCGGAGGACCGAA
GCTTCCGGACGACGAGGAACCGCCCAACATGGCCTCGGAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCA
CGACTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAG
CGAGTATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAGTACCAGAAAAGTCTGCTAGAGCAGTA
CCATCTGGGTCTGGATCAAAAACGCAGAAAATACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGAC
GAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGAT
TGCCAATGAAACCAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGCAAGACTGATACCACCTGC
GTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCAGAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGC

>7161_7161_12_ASL-GUSB_ASL_chr7_65541080_ENST00000395332_GUSB_chr7_65432894_ENST00000421103_length(amino acids)=191AA_BP=30
MLAKEVVSPVLSSRPGGPKLPDDEEPPNMASEAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFH
QDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASL-GUSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASL-GUSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASL-GUSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource