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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RAC1-EIF2AK1 (FusionGDB2 ID:71618) |
Fusion Gene Summary for RAC1-EIF2AK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAC1-EIF2AK1 | Fusion gene ID: 71618 | Hgene | Tgene | Gene symbol | RAC1 | EIF2AK1 | Gene ID | 6035 | 27102 |
| Gene name | ribonuclease A family member 1, pancreatic | eukaryotic translation initiation factor 2 alpha kinase 1 | |
| Synonyms | RAC1|RIB1|RNS1 | HCR|HRI | |
| Cytomap | 14q11.2 | 7p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic) | eukaryotic translation initiation factor 2-alpha kinase 1heme regulated initiation factor 2 alpha kinaseheme sensitive initiation factor 2a kinaseheme-controlled repressorheme-regulated eukaryotic initiation factor eIF-2-alpha kinaseheme-regulated in | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9BQI3 | |
| Ensembl transtripts involved in fusion gene | ENST00000488373, ENST00000348035, ENST00000356142, | ENST00000199389, ENST00000536084, ENST00000495565, | |
| Fusion gene scores | * DoF score | 19 X 12 X 6=1368 | 7 X 32 X 9=2016 |
| # samples | 19 | 27 | |
| ** MAII score | log2(19/1368*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/2016*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAC1 [Title/Abstract] AND EIF2AK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RAC1(6431672)-EIF2AK1(6068663), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAC1 | GO:0051607 | defense response to virus | 9826755 |
| Hgene | RAC1 | GO:0090501 | RNA phosphodiester bond hydrolysis | 9826755 |
| Tgene | EIF2AK1 | GO:1990641 | response to iron ion starvation | 11036079 |
| Fusion gene breakpoints across RAC1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EIF2AK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8687 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
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Fusion Gene ORF analysis for RAC1-EIF2AK1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000488373 | ENST00000199389 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| 3UTR-3CDS | ENST00000488373 | ENST00000536084 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| 3UTR-intron | ENST00000488373 | ENST00000495565 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| 5CDS-intron | ENST00000348035 | ENST00000495565 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| 5CDS-intron | ENST00000356142 | ENST00000495565 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| In-frame | ENST00000348035 | ENST00000199389 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| In-frame | ENST00000348035 | ENST00000536084 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| In-frame | ENST00000356142 | ENST00000199389 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| In-frame | ENST00000356142 | ENST00000536084 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000348035 | RAC1 | chr7 | 6431672 | + | ENST00000199389 | EIF2AK1 | chr7 | 6068663 | - | 3422 | 438 | 12 | 998 | 328 |
| ENST00000348035 | RAC1 | chr7 | 6431672 | + | ENST00000536084 | EIF2AK1 | chr7 | 6068663 | - | 1453 | 438 | 12 | 1211 | 399 |
| ENST00000356142 | RAC1 | chr7 | 6431672 | + | ENST00000199389 | EIF2AK1 | chr7 | 6068663 | - | 3406 | 422 | 14 | 982 | 322 |
| ENST00000356142 | RAC1 | chr7 | 6431672 | + | ENST00000536084 | EIF2AK1 | chr7 | 6068663 | - | 1437 | 422 | 14 | 1195 | 393 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000348035 | ENST00000199389 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - | 0.001941919 | 0.998058 |
| ENST00000348035 | ENST00000536084 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - | 0.004283056 | 0.995717 |
| ENST00000356142 | ENST00000199389 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - | 0.001955615 | 0.9980444 |
| ENST00000356142 | ENST00000536084 | RAC1 | chr7 | 6431672 | + | EIF2AK1 | chr7 | 6068663 | - | 0.004111081 | 0.9958889 |
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Fusion Genomic Features for RAC1-EIF2AK1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RAC1-EIF2AK1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6431672/chr7:6068663) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | EIF2AK1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes (By similarity). May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000348035 | + | 3 | 6 | 32_40 | 75 | 193.0 | Motif | Effector region |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000356142 | + | 3 | 7 | 32_40 | 75 | 212.0 | Motif | Effector region |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000348035 | + | 3 | 6 | 13_18 | 75 | 193.0 | Nucleotide binding | GTP |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000348035 | + | 3 | 6 | 30_35 | 75 | 193.0 | Nucleotide binding | GTP |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000356142 | + | 3 | 7 | 13_18 | 75 | 212.0 | Nucleotide binding | GTP |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000356142 | + | 3 | 7 | 30_35 | 75 | 212.0 | Nucleotide binding | GTP |
| Tgene | EIF2AK1 | chr7:6431672 | chr7:6068663 | ENST00000199389 | 10 | 15 | 552_557 | 444 | 631.0 | Repeat | Note=HRM 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000348035 | + | 3 | 6 | 116_118 | 75 | 193.0 | Nucleotide binding | GTP |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000348035 | + | 3 | 6 | 159_160 | 75 | 193.0 | Nucleotide binding | GTP |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000356142 | + | 3 | 7 | 116_118 | 75 | 212.0 | Nucleotide binding | GTP |
| Hgene | RAC1 | chr7:6431672 | chr7:6068663 | ENST00000356142 | + | 3 | 7 | 159_160 | 75 | 212.0 | Nucleotide binding | GTP |
| Tgene | EIF2AK1 | chr7:6431672 | chr7:6068663 | ENST00000199389 | 10 | 15 | 167_583 | 444 | 631.0 | Domain | Protein kinase | |
| Tgene | EIF2AK1 | chr7:6431672 | chr7:6068663 | ENST00000199389 | 10 | 15 | 173_181 | 444 | 631.0 | Nucleotide binding | ATP | |
| Tgene | EIF2AK1 | chr7:6431672 | chr7:6068663 | ENST00000199389 | 10 | 15 | 410_415 | 444 | 631.0 | Repeat | Note=HRM 1 |
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Fusion Gene Sequence for RAC1-EIF2AK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >71618_71618_1_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000348035_EIF2AK1_chr7_6068663_ENST00000199389_length(transcript)=3422nt_BP=438nt TTTCCTGTTTCTCTGCAGTTTTCCTCAGCTTTGGGTGGTGGCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGA CAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCGCGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCT GCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGAGCTGTAGGTAAAACTTGCCTA CTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAATGTTATGGTAGATGGAAAA CCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCGCAAACACCAAGAAATATT TTTCTTCATGGCCCTGATCAGCAAGTAAAAATAGGAGACTTTGGTCTGGCCTGCACAGACATCCTACAGAAGAACACAGACTGGACCAAC AGAAACGGGAAGAGAACACCAACACATACGTCCAGAGTGGGTACTTGTCTGTACGCTTCACCCGAACAGTTGGAAGGATCTGAGTATGAT GCCAAGTCAGATATGTACAGCTTGGGTGTGGTCCTGCTAGAGCTCTTTCAGCCGTTTGGAACAGAAATGGAGCGAGCAGAAGTTCTAACA GGTTTAAGAACTGGTCAGTTGCCGGAATCCCTCCGTAAAAGGTGTCCAGTGCAAGCCAAGTATATCCAGCACTTAACGAGAAGGAACTCA TCGCAGAGACCATCTGCCATTCAGCTGCTGCAGAGTGAACTTTTCCAAAATTCTGGAAATGTTAACCTCACCCTACAGATGAAGATAATA GAGCAAGAAAAAGAAATTGCAGAACTAAAGAAGCAGCTAAACCTCCTTTCTCAAGACAAAGGGGTGAGGGATGACGGAAAGGATGGGGGC GTGGGATGAAAGTGGACTTAACTTTTAAGGTAGTTAACTGGAATGTAAATTTTTAATCTTTATTAGGGTATAGTTGGTACAATGCTTCGT TGTATTTAGTAAGCCTTTACAAGACTTGTTAAAGATGTCAGAGTGCCCCAAGCTGCCGTTCCTTCCCTTCCTGCCCCACAAGCTCCTTTT CCTGAATTTCCTACCTAAATATTAACCATATGCCTAGTCTCTGAAACTAAAAACTTGGACCTCATCCTCAATTATTTTCTCCTTTCAACT CTGTTGACCCTCTGTCTGGTCTTCCTCTAGAAGGTACCGCAGAAATTGATGTGTGCTCCCTGCCCTCGTCACTGCCCAAGCCCGGGCCTG CACATACTCACTGGACTGTTCCAGTTTTGACAGCTGCCAGTCTTCCTGCCCCTTTCACACTGCAGCTGAAGTTCATTACCTGAAGGACGC CTCATCATTTCATTCCTTGGCTCCAAACCTTCTGCTGCCTCTAAGATAAAAGCTCAACTTCTTAACAGTGTACAGTGTGCAACTTCCAAC CTTTTTATCTGTTCTCTCCACCTTCAGTTTAGCGTCATTCCAAAACCACACCCTTGCAAAGCTTTGTACTCCGCACCCCAGATGATCTCC AGGCAGCTCAGATCTCTTTCCTGCCTTTGCCCTGCACTGTTCCCCGGTACTTCCTCCTTTATTGTAGCACTCAGCTCCCCAGCCAATCTG TACATCCCTCAGAGGCAGCGATCTGATGAATTGGTTTTTGAATCCCAGAAAGGGTCTGCCATGGAGTTGGCAGTCATCACGGTAGATGGC GTATGATTTTGCTGAATTTTAAATAAAATGAAAACCATAAATTACATGATGCTTTTATTGACACTTGACAACTGGCCTAAATAAAAAGAC TCTGACTCTAATACAAGTCCCCTTACTGATAATAGGCATGAAAGAGCACCATTCTTAAAATCTAAACCCTTTAAAATCAGTTACGGCAAT TCACTTAAGGAGCTTGAGGGCCGTGTTAAAAGGAGCCAGGTTTTCACAAGACCTCATCCACCTCTGCACATTGGCTGGCACTGTCACACT GCAGCCTCCGATCTGCTGGAGTACAGACCACAGCACCACGTCTGCTACGGTGAGTTCATTCCCAGCGAGCCAAGGGCTCTTCCCAAGAGC AGAGTTCATGGAGCGGAAAACAGCGGCTTTTTCTTTACTGCTTCCCTCTTTTAACTGAAAAATCGCAATATCTACCCAGCTATCTATAAG GGTTGCGTTGACAGCATTATGCTTCTGGCCAAACAGAGAGAACAAGAAACGTGCAATGTTCCCTTCGCCTTCGATGGGGCACATCGTCTG GATGCTGAATTTCATCTGCGTCTTCGGCACTGAAAAGAAAAAACACGCCAGGTAGCATCACCAGAGCAGCCCTGAGGGAAGTACTCGCAC AGTGGGGAAGGGGACAGTCACCAAACACCACAGACTGATGACATGGGAAAGGGTGTTTTCAAGAAGAACATCACATTTTCAGTCTGTCTC TAAGATGCTTACTACTGAAAAGGGTTTAAGTGCAAACTATGTTAAAAAAGTAACCAAAGAGTCATTCCTGGTATTTGATTATGACACTTC TGAAGCTAGAAGGGACCTCAGACCACCTGCTCCAATCCCTGCTGCCTAAGGTTTTGGGGGCTGAGGGCTGGAAACCCAGGAGCTGCATCT CCCAGGCTCTTGGCCTCATAATCGCCTTCTGTGAGACTGAGGGCAATTAAGATATGAATGACATGAACTCGCTTATCTCCATATCAACAT AAACCAGAAGAGGCATACATCTGTGGGATAGTCAATACATAACATCCTATCTTTATATGGCCATATGAGAAGATAACTTCAGTGTCCCTA TGATGGTAAGTTCTTGAATGTGAGGGCAAGATGGCTGTGATAGCCATGACTCCCCGCTTTGCCTGGTTGGACAGAACCCCCTTCCCCAAA TGCTCACAGTCCCCCCCTTGAGCTGTGTCTCACTCAGAGACCCTAAATTTTGCAGACGAACAAGGGCATCTTTGCGTTGCTTCATCTCTG CTCCTCCTCTAGAACTATCCCACAGGCTTTCTAGACTTAGAATATCTGACCTGATGCAAATCGCTATGTGGCCAGTATGCCACAGAATGT CCTAAACCCTTGCTGCCTCTTATCAAAACCATGTTGCACATCTCATCATATAGTACAGCTAACCCTTGAACAGTGGGGGGGTTAGGGACA CTGACCCCCGACTGCTGTGCAGTCGAAAATCCACATAAAACTTCTGACTCCTTCAAAACTTAAGCACTAATAGCCTACTATTCATGGGAA GCCTTACCCATCACAGTTGATTAACACGTTTTGTATGGTCTGTATATTATATGCTATATTCTTACAATAAACTTGAGAAAATGTTAAGAA >71618_71618_1_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000348035_EIF2AK1_chr7_6068663_ENST00000199389_length(amino acids)=328AA_BP=142 MQFSSALGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISY TTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRP -------------------------------------------------------------- >71618_71618_2_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000348035_EIF2AK1_chr7_6068663_ENST00000536084_length(transcript)=1453nt_BP=438nt TTTCCTGTTTCTCTGCAGTTTTCCTCAGCTTTGGGTGGTGGCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGA CAGCGGCCCCGGCACCCAGCGCCCCGCCGCCCGCAAGCCGCGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCT GCCGCCGCCGCCGCGGCCCAGCGAGCGGCCCTGATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGAGCTGTAGGTAAAACTTGCCTA CTGATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAATGTTATGGTAGATGGAAAA CCGGTGAATCTGGGCTTATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCGCAAACACCAAGAAATATT TTTCTTCATGGCCCTGATCAGCAAGTAAAAATAGGAGACTTTGGTCTGGCCTGCACAGACATCCTACAGAAGAACACAGACTGGACCAAC AGAAACGGGAAGAGAACACCAACACATACGTCCAGAGTGGGTACTTGTCTGTACGCTTCACCCGAACAGTTGGAAGGATCTGAGTATGAT GCCAAGTCAGATATGTACAGCTTGGGTGTGGTCCTGCTAGAGCTCTTTCAGCCGTTTGGAACAGAAATGGAGCGAGCAGAAGTTCTAACA GGTTTAAGAACTGGTCAGTTGCCGGAATCCCTCCGTAAAAGGTGTCCAGTGCAAGCCAAGTATATCCAGCACTTAACGAGAAGGAACTCA TCGCAGAGACCATCTGCCATTCAGCTGCTGCAGAGTGAACTTTTCCAAAATTCTGGAAATGTTAACCTCACCCTACAGATGAAGATAATA GAGCAAGAAAAAGAAATTGCAGAACTAAAGAAGCAGCTAAACCTCCTTTCTCAAGACAAAGGGTTTAGCGTCATTCCAAAACCACACCCT TGCAAAGCTTTGTACTCCGCACCCCAGATGATCTCCAGGCAGCTCAGATCTCTTTCCTGCCTTTGCCCTGCACTGTTCCCCGGTACTTCC TCCTTTATTGTAGCACTCAGCTCCCCAGCCAATCTGTACATCCCTCAGAGGCAGCGATCTGATGAATTGGTTTTTGAATCCCAGAAAGGG TCTGCCATGGAGTTGGCAGTCATCACGGTAGATGGCGTATGATTTTGCTGAATTTTAAATAAAATGAAAACCATAAATTACATGATGCTT TTATTGACACTTGACAACTGGCCTAAATAAAAAGACTCTGACTCTAATACAAGTCCCCTTACTGATAATAGGCATGAAAGAGCACCATTC TTAAAATCTAAACCCTTTAAAATCAGTTACGGCAATTCACTTAAGGAGCTTGAGGGCCGTGTTAAAAGGAGCCAGGTTTTCACAAGACCT >71618_71618_2_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000348035_EIF2AK1_chr7_6068663_ENST00000536084_length(amino acids)=399AA_BP=142 MQFSSALGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISY TTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGK RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRP SAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGFSVIPKPHPCKALYSAPQMISRQLRSLSCLCPALFPGTSSFIV -------------------------------------------------------------- >71618_71618_3_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000356142_EIF2AK1_chr7_6068663_ENST00000199389_length(transcript)=3406nt_BP=422nt AGTTTTCCTCAGCTTTGGGTGGTGGCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACC CAGCGCCCCGCCGCCCGCAAGCCGCGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGG CCCAGCGAGCGGCCCTGATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGAGCTGTAGGTAAAACTTGCCTACTGATCAGTTACACAA CCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAATGTTATGGTAGATGGAAAACCGGTGAATCTGGGCT TATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCGCAAACACCAAGAAATATTTTTCTTCATGGCCCTG ATCAGCAAGTAAAAATAGGAGACTTTGGTCTGGCCTGCACAGACATCCTACAGAAGAACACAGACTGGACCAACAGAAACGGGAAGAGAA CACCAACACATACGTCCAGAGTGGGTACTTGTCTGTACGCTTCACCCGAACAGTTGGAAGGATCTGAGTATGATGCCAAGTCAGATATGT ACAGCTTGGGTGTGGTCCTGCTAGAGCTCTTTCAGCCGTTTGGAACAGAAATGGAGCGAGCAGAAGTTCTAACAGGTTTAAGAACTGGTC AGTTGCCGGAATCCCTCCGTAAAAGGTGTCCAGTGCAAGCCAAGTATATCCAGCACTTAACGAGAAGGAACTCATCGCAGAGACCATCTG CCATTCAGCTGCTGCAGAGTGAACTTTTCCAAAATTCTGGAAATGTTAACCTCACCCTACAGATGAAGATAATAGAGCAAGAAAAAGAAA TTGCAGAACTAAAGAAGCAGCTAAACCTCCTTTCTCAAGACAAAGGGGTGAGGGATGACGGAAAGGATGGGGGCGTGGGATGAAAGTGGA CTTAACTTTTAAGGTAGTTAACTGGAATGTAAATTTTTAATCTTTATTAGGGTATAGTTGGTACAATGCTTCGTTGTATTTAGTAAGCCT TTACAAGACTTGTTAAAGATGTCAGAGTGCCCCAAGCTGCCGTTCCTTCCCTTCCTGCCCCACAAGCTCCTTTTCCTGAATTTCCTACCT AAATATTAACCATATGCCTAGTCTCTGAAACTAAAAACTTGGACCTCATCCTCAATTATTTTCTCCTTTCAACTCTGTTGACCCTCTGTC TGGTCTTCCTCTAGAAGGTACCGCAGAAATTGATGTGTGCTCCCTGCCCTCGTCACTGCCCAAGCCCGGGCCTGCACATACTCACTGGAC TGTTCCAGTTTTGACAGCTGCCAGTCTTCCTGCCCCTTTCACACTGCAGCTGAAGTTCATTACCTGAAGGACGCCTCATCATTTCATTCC TTGGCTCCAAACCTTCTGCTGCCTCTAAGATAAAAGCTCAACTTCTTAACAGTGTACAGTGTGCAACTTCCAACCTTTTTATCTGTTCTC TCCACCTTCAGTTTAGCGTCATTCCAAAACCACACCCTTGCAAAGCTTTGTACTCCGCACCCCAGATGATCTCCAGGCAGCTCAGATCTC TTTCCTGCCTTTGCCCTGCACTGTTCCCCGGTACTTCCTCCTTTATTGTAGCACTCAGCTCCCCAGCCAATCTGTACATCCCTCAGAGGC AGCGATCTGATGAATTGGTTTTTGAATCCCAGAAAGGGTCTGCCATGGAGTTGGCAGTCATCACGGTAGATGGCGTATGATTTTGCTGAA TTTTAAATAAAATGAAAACCATAAATTACATGATGCTTTTATTGACACTTGACAACTGGCCTAAATAAAAAGACTCTGACTCTAATACAA GTCCCCTTACTGATAATAGGCATGAAAGAGCACCATTCTTAAAATCTAAACCCTTTAAAATCAGTTACGGCAATTCACTTAAGGAGCTTG AGGGCCGTGTTAAAAGGAGCCAGGTTTTCACAAGACCTCATCCACCTCTGCACATTGGCTGGCACTGTCACACTGCAGCCTCCGATCTGC TGGAGTACAGACCACAGCACCACGTCTGCTACGGTGAGTTCATTCCCAGCGAGCCAAGGGCTCTTCCCAAGAGCAGAGTTCATGGAGCGG AAAACAGCGGCTTTTTCTTTACTGCTTCCCTCTTTTAACTGAAAAATCGCAATATCTACCCAGCTATCTATAAGGGTTGCGTTGACAGCA TTATGCTTCTGGCCAAACAGAGAGAACAAGAAACGTGCAATGTTCCCTTCGCCTTCGATGGGGCACATCGTCTGGATGCTGAATTTCATC TGCGTCTTCGGCACTGAAAAGAAAAAACACGCCAGGTAGCATCACCAGAGCAGCCCTGAGGGAAGTACTCGCACAGTGGGGAAGGGGACA GTCACCAAACACCACAGACTGATGACATGGGAAAGGGTGTTTTCAAGAAGAACATCACATTTTCAGTCTGTCTCTAAGATGCTTACTACT GAAAAGGGTTTAAGTGCAAACTATGTTAAAAAAGTAACCAAAGAGTCATTCCTGGTATTTGATTATGACACTTCTGAAGCTAGAAGGGAC CTCAGACCACCTGCTCCAATCCCTGCTGCCTAAGGTTTTGGGGGCTGAGGGCTGGAAACCCAGGAGCTGCATCTCCCAGGCTCTTGGCCT CATAATCGCCTTCTGTGAGACTGAGGGCAATTAAGATATGAATGACATGAACTCGCTTATCTCCATATCAACATAAACCAGAAGAGGCAT ACATCTGTGGGATAGTCAATACATAACATCCTATCTTTATATGGCCATATGAGAAGATAACTTCAGTGTCCCTATGATGGTAAGTTCTTG AATGTGAGGGCAAGATGGCTGTGATAGCCATGACTCCCCGCTTTGCCTGGTTGGACAGAACCCCCTTCCCCAAATGCTCACAGTCCCCCC CTTGAGCTGTGTCTCACTCAGAGACCCTAAATTTTGCAGACGAACAAGGGCATCTTTGCGTTGCTTCATCTCTGCTCCTCCTCTAGAACT ATCCCACAGGCTTTCTAGACTTAGAATATCTGACCTGATGCAAATCGCTATGTGGCCAGTATGCCACAGAATGTCCTAAACCCTTGCTGC CTCTTATCAAAACCATGTTGCACATCTCATCATATAGTACAGCTAACCCTTGAACAGTGGGGGGGTTAGGGACACTGACCCCCGACTGCT GTGCAGTCGAAAATCCACATAAAACTTCTGACTCCTTCAAAACTTAAGCACTAATAGCCTACTATTCATGGGAAGCCTTACCCATCACAG >71618_71618_3_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000356142_EIF2AK1_chr7_6068663_ENST00000199389_length(amino acids)=322AA_BP=136 MGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISYTTNAFP GEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHT SRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLL -------------------------------------------------------------- >71618_71618_4_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000356142_EIF2AK1_chr7_6068663_ENST00000536084_length(transcript)=1437nt_BP=422nt AGTTTTCCTCAGCTTTGGGTGGTGGCCGCTGCCGGGCATCGGCTTCCAGTCCGCGGAGGGCGAGGCGGCGTGGACAGCGGCCCCGGCACC CAGCGCCCCGCCGCCCGCAAGCCGCGCGCCCGTCCGCCGCGCCCCGAGCCCGCCGCTTCCTATCTCAGCGCCCTGCCGCCGCCGCCGCGG CCCAGCGAGCGGCCCTGATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGAGCTGTAGGTAAAACTTGCCTACTGATCAGTTACACAA CCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTATTCTGCCAATGTTATGGTAGATGGAAAACCGGTGAATCTGGGCT TATGGGATACAGCTGGACAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCGCAAACACCAAGAAATATTTTTCTTCATGGCCCTG ATCAGCAAGTAAAAATAGGAGACTTTGGTCTGGCCTGCACAGACATCCTACAGAAGAACACAGACTGGACCAACAGAAACGGGAAGAGAA CACCAACACATACGTCCAGAGTGGGTACTTGTCTGTACGCTTCACCCGAACAGTTGGAAGGATCTGAGTATGATGCCAAGTCAGATATGT ACAGCTTGGGTGTGGTCCTGCTAGAGCTCTTTCAGCCGTTTGGAACAGAAATGGAGCGAGCAGAAGTTCTAACAGGTTTAAGAACTGGTC AGTTGCCGGAATCCCTCCGTAAAAGGTGTCCAGTGCAAGCCAAGTATATCCAGCACTTAACGAGAAGGAACTCATCGCAGAGACCATCTG CCATTCAGCTGCTGCAGAGTGAACTTTTCCAAAATTCTGGAAATGTTAACCTCACCCTACAGATGAAGATAATAGAGCAAGAAAAAGAAA TTGCAGAACTAAAGAAGCAGCTAAACCTCCTTTCTCAAGACAAAGGGTTTAGCGTCATTCCAAAACCACACCCTTGCAAAGCTTTGTACT CCGCACCCCAGATGATCTCCAGGCAGCTCAGATCTCTTTCCTGCCTTTGCCCTGCACTGTTCCCCGGTACTTCCTCCTTTATTGTAGCAC TCAGCTCCCCAGCCAATCTGTACATCCCTCAGAGGCAGCGATCTGATGAATTGGTTTTTGAATCCCAGAAAGGGTCTGCCATGGAGTTGG CAGTCATCACGGTAGATGGCGTATGATTTTGCTGAATTTTAAATAAAATGAAAACCATAAATTACATGATGCTTTTATTGACACTTGACA ACTGGCCTAAATAAAAAGACTCTGACTCTAATACAAGTCCCCTTACTGATAATAGGCATGAAAGAGCACCATTCTTAAAATCTAAACCCT >71618_71618_4_RAC1-EIF2AK1_RAC1_chr7_6431672_ENST00000356142_EIF2AK1_chr7_6068663_ENST00000536084_length(amino acids)=393AA_BP=136 MGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISYTTNAFP GEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHT SRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLL QSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGFSVIPKPHPCKALYSAPQMISRQLRSLSCLCPALFPGTSSFIVALSSPA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RAC1-EIF2AK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RAC1-EIF2AK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RAC1-EIF2AK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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